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Conserved domains on  [gi|491114826|ref|WP_004973283|]
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MULTISPECIES: response regulator transcription factor [Acinetobacter]

Protein Classification

response regulator transcription factor( domain architecture ID 1013612)

two-component system response regulator transcription factor binds DNA upon phosphorylation and functions as transcriptional regulator

CATH:  3.40.50.2300
Gene Ontology:  GO:0000156|GO:0000160|GO:0003677|GO:0006355
PubMed:  31100988|10966457
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15369 super family cl33127
two component system response regulator;
7-234 8.54e-29

two component system response regulator;


The actual alignment was detected with superfamily member PRK15369:

Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 107.86  E-value: 8.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826   7 ILPVPVLIVEDEPIIQSRLRKIL------HDIGYQDDMLFFVShlkaamTCIEDHPiALALVDLGLPDGNGKELIEQLHF 80
Cdd:PRK15369   1 MKNYKILLVDDHELIINGIKNMLapypryKIVGQVDNGLEVYN------ACRQLEP-DIVILDLGLPGMNGLDVIPQLHQ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  81 RDPSALILVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAPIDPFIAREILSQIShqkvpvltedlsd 160
Cdd:PRK15369  74 RWPAMNILVLTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDPALNREAILALL------------- 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491114826 161 radaQAFNSHYEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:PRK15369 141 ----NADDTNPPLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
 
Name Accession Description Interval E-value
PRK15369 PRK15369
two component system response regulator;
7-234 8.54e-29

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 107.86  E-value: 8.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826   7 ILPVPVLIVEDEPIIQSRLRKIL------HDIGYQDDMLFFVShlkaamTCIEDHPiALALVDLGLPDGNGKELIEQLHF 80
Cdd:PRK15369   1 MKNYKILLVDDHELIINGIKNMLapypryKIVGQVDNGLEVYN------ACRQLEP-DIVILDLGLPGMNGLDVIPQLHQ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  81 RDPSALILVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAPIDPFIAREILSQIShqkvpvltedlsd 160
Cdd:PRK15369  74 RWPAMNILVLTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDPALNREAILALL------------- 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491114826 161 radaQAFNSHYEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:PRK15369 141 ----NADDTNPPLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 167-234 2.03e-23

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 89.63  E-value: 2.03e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491114826 167 FNSHYEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:COG5905    6 STSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 12-129 4.58e-20

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 82.17  E-value: 4.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILhdiGYQDDM--LFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILV 89
Cdd:cd17535    1 VLIVDDHPLVREGLRRLL---ESEPDIevVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIV 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 491114826  90 ISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd17535   78 LTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 172-228 7.01e-20

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 79.88  E-value: 7.01e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 491114826   172 EQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTA 228
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
GerE pfam00196
Bacterial regulatory proteins, luxR family;
172-228 1.09e-16

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 71.46  E-value: 1.09e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491114826  172 EQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTA 228
Cdd:pfam00196   1 DSLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 107-216 1.60e-04

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 41.01  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  107 ATGYVlKERDDAEIIIA--------IRSILRGGAPIDPFIAR----EILSQISHQKV--PVLTEDLSDRADAQAFNSHYE 172
Cdd:TIGR02985  18 ARRYV-KDEEDAEDIVQdvflklweNRETLEISESIKAYLFTivknRCLNYLRHKQVeeKYQEELAEIEERELSEADPEE 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491114826  173 QLTNRELE--ILNLVA---------------QGLSNREIAEQLFVSRYTVESHIKHIYRKL 216
Cdd:TIGR02985  97 ELEAKELEeiIEEAIEklpeqcreifilsrfEGLSNKEIAEELGISVKTVEYHITKALKFL 157
 
Name Accession Description Interval E-value
PRK15369 PRK15369
two component system response regulator;
7-234 8.54e-29

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 107.86  E-value: 8.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826   7 ILPVPVLIVEDEPIIQSRLRKIL------HDIGYQDDMLFFVShlkaamTCIEDHPiALALVDLGLPDGNGKELIEQLHF 80
Cdd:PRK15369   1 MKNYKILLVDDHELIINGIKNMLapypryKIVGQVDNGLEVYN------ACRQLEP-DIVILDLGLPGMNGLDVIPQLHQ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  81 RDPSALILVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAPIDPFIAREILSQIShqkvpvltedlsd 160
Cdd:PRK15369  74 RWPAMNILVLTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDPALNREAILALL------------- 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491114826 161 radaQAFNSHYEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:PRK15369 141 ----NADDTNPPLLTPRERQILKLITEGYTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARRLGLI 210
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 9-224 1.33e-27

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 104.73  E-value: 1.33e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826   9 PVPVLIVEDEPIIQSRLRKIlhdIGYQDDMLFF--VSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSAL 86
Cdd:PRK10651   6 PATILLIDDHPMLRTGVKQL---ISMAPDITVVgeASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  87 ILVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGgapidpfiarEILsqISHQKVPVLTEDLsdRADAQA 166
Cdd:PRK10651  83 IVVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAG----------EMV--LSEALTPVLAASL--RANRAT 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491114826 167 FNSHYEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKA 224
Cdd:PRK10651 149 TERDVNQLTPRERDILKLIAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEA 206
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 167-234 2.03e-23

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 89.63  E-value: 2.03e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491114826 167 FNSHYEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:COG5905    6 STSHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALRLGLL 73
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 12-216 1.25e-22

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 91.17  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:COG0745    4 ILVVEDDPDIRELLADALEREGYE---VDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRggapidpfiareilsqiSHQKVPVLTEDLSDRADAQAF-NSH 170
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLR-----------------RRAAEVLRVGDLLDLAAREVTrDGE 143

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 491114826 171 YEQLTNRELEILNLVA----QGLSNREIAEQL----FVSRYTVESHIKHIYRKL 216
Cdd:COG0745  144 PVELTPKEFRLLELLMrnpgRVVSREQLLEEVwgydYGDDRTVDVHISRLRKKL 197
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
9-234 3.62e-22

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 90.32  E-value: 3.62e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826   9 PVPVLIVEDEPIIQSRLRKILHDiGYQDDMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALIL 88
Cdd:PRK09935   3 PASVIIMDTHPIIRMSIEVLLQK-NSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  89 VISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGApidpFIAREILSQISHQKVPVltedlsdradaqafN 168
Cdd:PRK09935  82 FLSSKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYT----FFPSETLNYIKSNKCST--------------N 143

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491114826 169 SHYEQ-LTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:PRK09935 144 SSTDTvLSNREVTILRYLVSGLSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAKLHELL 210
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 174-234 2.15e-21

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 86.10  E-value: 2.15e-21
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491114826 174 LTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:COG2197   70 LTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGLL 130
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
4-224 4.30e-21

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 87.60  E-value: 4.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826   4 MEAILPVPVLIVEDEPIIQSRLRKILH-DIGYqdDMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRD 82
Cdd:PRK10403   1 MPEATPFQVLIVDDHPLMRRGVRQLLElDPGF--EVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  83 PSALILVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGapiDPFIAReilsqishqkvpvLTEDLSDRA 162
Cdd:PRK10403  79 VTAQIIILTVSDASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGS---KVFSER-------------VNQYLRERE 142

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491114826 163 DAQAFNSHYEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKA 224
Cdd:PRK10403 143 MFGAEEDPFSVLTERELDVLHELAQGLSNKQIASVLNISEQTVKVHIRNLLRKLNVRSRVAA 204
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 12-129 5.28e-21

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 90.41  E-value: 5.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:COG2204    5 ILVVDDDPDIRRLLKELLERAGYE---VETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLT 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:COG2204   82 GYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALE 119
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 12-218 3.56e-20

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 84.38  E-value: 3.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQ-------DDmlfFVSHLKAAMT-CIedhpialaLVDLGLPDGNGKELIEQLHFRDP 83
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRvetfasaEA---FLAALDPDRPgCL--------LLDVRMPGMSGLELQEELAARGS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  84 SALILVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGApidpfiareilsqishqkvpvltEDLSDRAD 163
Cdd:COG4566   71 PLPVIFLTGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDR-----------------------ARRAERAR 127

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 491114826 164 AQAFNSHYEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSV 218
Cdd:COG4566  128 RAELRARLASLTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLGA 182
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 12-129 3.99e-20

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 83.10  E-value: 3.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMLFFVShLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:COG4565    6 VLIVEDDPMVAELLRRYLERLPGFEVVGVASS-GEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVIT 84

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:COG4565   85 AARDPETVREALRAGVVDYLIKPFTFERLREALERYLE 122
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 12-129 4.58e-20

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 82.17  E-value: 4.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILhdiGYQDDM--LFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILV 89
Cdd:cd17535    1 VLIVDDHPLVREGLRRLL---ESEPDIevVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIV 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 491114826  90 ISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd17535   78 LTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVAA 117
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 172-228 7.01e-20

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 79.88  E-value: 7.01e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 491114826   172 EQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTA 228
Cdd:smart00421   2 ASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 12-113 1.48e-18

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 77.89  E-value: 1.48e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDI-GYQDdmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVI 90
Cdd:COG4753    2 VLIVDDEPLIREGLKRILEWEaGFEV--VGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIIL 79

                         90       100
                 ....*....|....*....|...
gi 491114826  91 SAWSTQDSLFSAIQAGATGYVLK 113
Cdd:COG4753   80 SGYSDFEYAQEAIKLGADDYLLK 102
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 12-164 1.97e-17

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 76.87  E-value: 1.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQL--HFRDPSALILV 89
Cdd:COG3706    4 ILVVDDDPTNRKLLRRLLEAAGYE---VVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLraDPRTADIPIIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  90 ISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGApiDPF--------------IAREILSQISHQKVPVLT 155
Cdd:COG3706   81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLVARYGG--EEFaillpgtdlegalaVAERIREAVAELPSLRVT 158

                        170
                 ....*....|....*.
gi 491114826 156 -------EDLSDRADA 164
Cdd:COG3706  159 vsigvagDSLLKRADA 174
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
183-234 2.64e-17

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 76.67  E-value: 2.64e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 491114826 183 NLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:COG2909  132 RLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARARELGLL 183
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 13-113 3.37e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 74.19  E-value: 3.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  13 LIVEDEPIIQSRLRKILHDIGYQDDMlffVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVISA 92
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDT---AADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTA 77

                         90       100
                 ....*....|....*....|.
gi 491114826  93 WSTQDSLFSAIQAGATGYVLK 113
Cdd:cd00156   78 KADEEDAVRALELGADDYLVK 98
GerE pfam00196
Bacterial regulatory proteins, luxR family;
172-228 1.09e-16

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 71.46  E-value: 1.09e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491114826  172 EQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTA 228
Cdd:pfam00196   1 DSLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 12-133 1.36e-16

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 73.35  E-value: 1.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQL--HFRDPSALILV 89
Cdd:COG0784    8 ILVVDDNPDNRELLRRLLERLGYE---VTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIraLPRLPDIPIIA 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 491114826  90 ISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAP 133
Cdd:COG0784   85 LTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 4-129 1.37e-16

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 75.59  E-value: 1.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826   4 MEAILPVPVLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDP 83
Cdd:COG3437    1 MRTGQAPTVLIVDDDPENLELLRQLLRTLGYD---VVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPS 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 491114826  84 SALI--LVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:COG3437   78 TRDIpvIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALE 125
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 12-125 1.39e-16

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 72.95  E-value: 1.39e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826   12 VLIVEDEPIIQSRLRKILHDIGYQDDmlfFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVA---EADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILT 77

                          90       100       110
                  ....*....|....*....|....*....|....
gi 491114826   92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIR 125
Cdd:pfam00072  78 AHGDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 174-229 1.45e-16

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 71.03  E-value: 1.45e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491114826 174 LTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTAR 229
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAI 56
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 12-113 3.15e-16

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 73.80  E-value: 3.15e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:COG4567    7 LLLVDDDEAFARVLARALERRGFE---VTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT 83

                         90       100
                 ....*....|....*....|..
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLK 113
Cdd:COG4567   84 GYASIATAVEAIKLGADDYLAK 105
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
44-234 7.30e-16

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 73.25  E-value: 7.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  44 HLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIA 123
Cdd:COG2771    3 LLALALLLLALLLLLLALLALLLLLLLAALLLLLALLLLAALLLLAAAAAALAAALAAALLLGLLLLLLIALLLLLLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826 124 IRSILRGGAPIDPFIAREILSQISHQKVPVLTEDLSDRADAQAFnshyeQLTNRELEILNLVAQGLSNREIAEQLFVSRY 203
Cdd:COG2771   83 ALLLLLALLALLAALLARLAALLLALALAALLLAALARLLARAP-----GLTPREREVLRLLAEGLTLKEIARILGISER 157

                        170       180       190
                 ....*....|....*....|....*....|.
gi 491114826 204 TVESHIKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:COG2771  158 TVRTHLKRIYRKLGVSSRAELVALALRLGLI 188
PRK10360 PRK10360
transcriptional regulator UhpA;
10-219 1.00e-14

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 70.01  E-value: 1.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  10 VPVLIVEDEPIIQSRLRKILhdiGYQDDMLF---FVSHlKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLhfrdPSAL 86
Cdd:PRK10360   2 ITVALIDDHLIVRSGFAQLL---GLEPDLQVvaeFGSG-REALAGLPGRGVQVCICDISMPDISGLELLSQL----PKGM 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  87 ILVIsaWSTQDS---LFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAPIDPFIAREILSqishqkvpvltedlsDRAD 163
Cdd:PRK10360  74 ATIM--LSVHDSpalVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLAS---------------GRQD 136

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491114826 164 AqafnshyeqLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVT 219
Cdd:PRK10360 137 P---------LTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVS 183
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 12-129 2.36e-14

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 67.12  E-value: 2.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDmlfFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVD---WVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILT 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd17624   78 ARDGVDDRVAGLDAGADDYLVKPFALEELLARLRALLR 115
PRK09483 PRK09483
response regulator; Provisional
 12-218 2.48e-14

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 69.36  E-value: 2.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIgyqddmlffvSHLKAA--MTCIED-------HPIALALVDLGLPDGNGKELIEQLHFRD 82
Cdd:PRK09483   4 VLLVDDHELVRAGIRRILEDI----------KGIKVVgeACCGEDavkwcrtNAVDVVLMDMNMPGIGGLEATRKILRYT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  83 PSALILVISAwSTQDSLFSAI-QAGATGYVLKERDDAEIIIAIRSILRGGAPIDPFIAREI-LSQISHQKvpvltedlsd 160
Cdd:PRK09483  74 PDVKIIMLTV-HTENPLPAKVmQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIASDIAQQMaLSQIEPAT---------- 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491114826 161 radaqafNSHYEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSV 218
Cdd:PRK09483 143 -------ENPFASLSERELQIMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNI 193
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 12-129 2.66e-13

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 64.28  E-value: 2.66e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491114826  92 AWSTqdslFS----AIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd17536   81 GYDD----FEyaqkAIRLGVVDYLLKPVDEEELEEALEKAKE 118
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 12-128 3.11e-12

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 61.44  E-value: 3.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYK---VTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVIT 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd17572   78 AHGSVDIAVEAMRLGAYDFLEKPFDADRLRVTVRNAL 114
PRK10100 PRK10100
transcriptional regulator CsgD;
174-228 7.53e-12

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 62.58  E-value: 7.53e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 491114826 174 LTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTA 228
Cdd:PRK10100 156 LTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVSWA 210
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 12-129 1.25e-11

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 59.72  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17569    3 ILLVDDEPNILKALKRLLRREGYE---VLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRILLT 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491114826  92 AWSTQDSLFSAIQAGAT-GYVLKERDDAEIIIAIRSILR 129
Cdd:cd17569   80 GYADLDAAIEAINEGEIyRFLTKPWDDEELKETIRQALE 118
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
174-231 1.37e-11

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 63.42  E-value: 1.37e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491114826 174 LTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTL 231
Cdd:PRK04841 839 LTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQHAQDL 896
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
13-216 1.51e-11

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 61.45  E-value: 1.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  13 LIVEDEPIIQSRLRKIL--HDIGYQDDMLFFVSHLKAAMTCIEDhpiaLALVDLGLPDGNGKELIEQLHFRDPSALILVI 90
Cdd:PRK09958   4 IIIDDHPLAIAAIRNLLikNDIEILAELTEGGSAVQRVETLKPD----IVIIDVDIPGVNGIQVLETLRKRQYSGIIIIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  91 SAwsTQDSLFS--AIQAGATGYVLKERDDAEIIIAIRSILRGGAPIDPFIAREILSQIShqkvpvltedlsdraDAQAFN 168
Cdd:PRK09958  80 SA--KNDHFYGkhCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTS---------------DQQKLD 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 491114826 169 ShyeqLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKL 216
Cdd:PRK09958 143 S----LSKQEISVMRYILDGKDNNDIAEKMFISNKTVSTYKSRLMEKL 186
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 12-128 1.07e-10

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 57.29  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYqdDMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17542    3 VLIVDDAAFMRMMLKDILTKAGY--EVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd17542   81 AMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 12-129 1.15e-10

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 58.81  E-value: 1.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHfRDPSALILVIS 91
Cdd:COG3707    6 VLVVDDEPLRRADLREGLREAGYE--VVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQIS-EERPAPVILLT 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALA 120
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 12-123 1.18e-10

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 57.07  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17563    3 LLLVDDDEVFAERLARALERRGFE---VETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLT 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIA 123
Cdd:cd17563   80 GYASIATAVEAIKLGADDYLAKPADADEILAA 111
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 12-113 3.40e-10

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 55.71  E-value: 3.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDdMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd19925    3 VLIVEDDPMVAEIHRAYVEQVPGFT-VIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVT 81

                         90       100
                 ....*....|....*....|..
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLK 113
Cdd:cd19925   82 AANDVETVREALRLGVVDYLIK 103
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 12-113 8.00e-10

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 54.48  E-value: 8.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmlFFVSH-----LKAAMTCIEDhpiaLALVDLGLPDGNGKELIEQLhfRDPSAL 86
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHGYR----VFEAEtgqegLLEAATRKPD----LIILDLGLPDMDGLEVIRRL--REWSAV 70

                         90       100
                 ....*....|....*....|....*...
gi 491114826  87 -ILVISAWSTQDSLFSAIQAGATGYVLK 113
Cdd:cd17620   71 pVIVLSARDEESDKIAALDAGADDYLTK 98
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 12-127 1.04e-09

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 54.53  E-value: 1.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMlffVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17554    3 ILVVDDEENIRELYKEELEDEGYEVVT---AGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICT 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491114826  92 AWSTQDSLFSAIQAGAtgYVLKERDDAEIIIAIRSI 127
Cdd:cd17554   80 AYSEYKSDFSSWAADA--YVVKSSDLTELKETIKRL 113
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 12-129 2.09e-09

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 53.83  E-value: 2.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMlffVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAGYVVDV---AEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILT 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd19934   78 ARDSWQDKVEGLDAGADDYLTKPFHIEELLARLRALIR 115
PRK10816 PRK10816
two-component system response regulator PhoP;
12-129 2.33e-09

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 55.52  E-value: 2.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMlffVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:PRK10816   3 VLVVEDNALLRHHLKVQLQDAGHQVDA---AEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLT 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:PRK10816  80 ARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMR 117
PRK10643 PRK10643
two-component system response regulator PmrA;
12-216 3.01e-09

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 55.43  E-value: 3.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMlffVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:PRK10643   3 ILIVEDDTLLLQGLILALQTEGYACDC---ASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLILT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRggapidpfiaREILSQISHQKVPVLTEDLSDRA---DAQAFn 168
Cdd:PRK10643  80 ARDTLEDRVAGLDVGADDYLVKPFALEELHARIRALIR----------RHQGQGENELQVGNLTLNLGRQQvwlDGQEL- 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491114826 169 shyeQLTNRELEILN---LVAQGLSNREIAEQ-LF-----VSRYTVESHIKHIYRKL 216
Cdd:PRK10643 149 ----ILTPKEFALLSrlmLKAGSPVHREILYQdIYnwddePSSNTLEVHIHNLRDKV 201
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 12-129 4.68e-09

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 54.82  E-value: 4.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGyQDDMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:COG3279    4 ILIVDDEPLARERLERLLEKYP-DLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTT 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWStqDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:COG3279   83 AYD--EYALEAFEVNAVDYLLKPIDEERLAKALEKAKE 118
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 12-128 6.48e-09

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 52.41  E-value: 6.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYqdDMLFFVSHLKAAMTCIEDHPIALALVDLGLPDG-NGKELIEQLH--FRDPsalIL 88
Cdd:cd17534    3 ILIVEDEAIIALDLKEILESLGY--EVVGIADSGEEAIELAEENKPDLILMDINLKGDmDGIEAAREIRekFDIP---VI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 491114826  89 VISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd17534   78 FLTAYSDEETLERAKETNPYGYLVKPFNERELKAAIELAL 117
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 12-234 6.58e-09

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 54.55  E-value: 6.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDML---FFVSHLkaAMTCIEDhpiaLALVDLGLPDGNGKELIEQLHFRDPSALIL 88
Cdd:PRK09836   3 LLIVEDEKKTGEYLTKGLTEAGFVVDLAdngLNGYHL--AMTGDYD----LIILDIMLPDVNGWDIVRMLRSANKGMPIL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  89 VISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAPIDPfiareilsqISHQKVPVLTEDLSDRADAQAFN 168
Cdd:PRK09836  77 LLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVII---------ESQFQVADLMVDLVSRKVTRSGT 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491114826 169 ShyEQLTNRELEILNLVA--QG--LSNREIAEQLFVSRYTVESH-----IKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:PRK09836 148 R--ITLTSKEFTLLEFFLrhQGevLPRSLIASQVWDMNFDSDTNaidvaVKRLRGKIDNDFEPKLIQTVRGVGYM 220
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 12-113 1.38e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 51.32  E-value: 1.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDmlfFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQL--HFRD-PSALIL 88
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVD---VAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIreLEGGgRRTPII 77

                         90       100
                 ....*....|....*....|....*
gi 491114826  89 VISAWSTQDSLFSAIQAGATGYVLK 113
Cdd:cd17546   78 ALTANALEEDREKCLEAGMDDYLSK 102
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 12-128 1.47e-08

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 51.22  E-value: 1.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMLffvSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHfRDPSALILVIS 91
Cdd:cd19938    2 ILIVEDEPKLAQLLIDYLRAAGYAPTLL---AHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIR-RFSDVPIIMVT 77

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd19938   78 ARVEEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 12-113 1.55e-08

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 51.29  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYqddmLFFVSH---LKAAMTCiEDHPIALALVDLGLPDGNGKELIEQLHFRDPSAL-- 86
Cdd:cd17551    3 ILIVDDNPTNLLLLEALLRSAGY----LEVVSFtdpREALAWC-RENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDvp 77

                         90       100
                 ....*....|....*....|....*..
gi 491114826  87 ILVISAWSTQDSLFSAIQAGATGYVLK 113
Cdd:cd17551   78 IVMITADTDREVRLRALEAGATDFLTK 104
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 12-213 1.67e-08

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 53.27  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLhfRDPSAL-ILVI 90
Cdd:PRK10529   4 VLIVEDEQAIRRFLRTALEGDGMR---VFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDL--RQWSAIpVIVL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  91 SAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR---GGAPIDPFIareilsqishqKVPVLTEDLSDRADAQAF 167
Cdd:PRK10529  79 SARSEESDKIAALDAGADDYLSKPFGIGELQARLRVALRrhsATPAPDPLV-----------KFSDVTVDLAARVIHRGE 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 491114826 168 NS-HYEQLTNREL-EILNLVAQGLSNREIAEQLFVSRYTVESHIKHIY 213
Cdd:PRK10529 148 EEvHLTPIEFRLLaVLLNNAGKVLTQRQLLNQVWGPNAVEHSHYLRIY 195
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 12-113 2.79e-08

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 50.23  E-value: 2.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMGLD---VRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVIT 77

                         90       100
                 ....*....|....*....|..
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLK 113
Cdd:cd19926   78 AYGSLDTAIEALKAGAFDFLTK 99
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
12-129 3.16e-08

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 53.31  E-value: 3.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQGFE---THCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMT 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:PRK11361  84 AYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQ 121
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 12-116 3.28e-08

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 50.12  E-value: 3.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMlffVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQADV---AESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIKEKHPSIVVIVLS 77

                         90       100
                 ....*....|....*....|....*
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERD 116
Cdd:cd17573   78 DNPKTEQEIEAFKEGADDYIAKPFD 102
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 12-125 5.06e-08

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 49.69  E-value: 5.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17619    3 ILIVEDEPVTRATLKSYFEQEGYD---VSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQSEVGIILVTG 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491114826  92 AWSTQDSLFsAIQAGATGYVLKERDDAEIIIAIR 125
Cdd:cd17619   80 RDDEVDRIV-GLEIGADDYVTKPFNPRELLVRAK 112
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 13-113 8.72e-08

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 48.56  E-value: 8.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  13 LIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVISA 92
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYE---VDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTA 77

                         90       100
                 ....*....|....*....|.
gi 491114826  93 WSTQDSLFSAIQAGATGYVLK 113
Cdd:cd17574   78 KDEEEDKVLGLELGADDYITK 98
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
12-216 1.09e-07

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 50.96  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmlFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:PRK10955   4 ILLVDDDRELTSLLKELLEMEGFN----VIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGIDTLKELRQTHQTPVIMLTA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  92 AWSTQDSLFsAIQAGATGYVLKERDDAEIIIAIRSILRggapidpfiaREILS---QISHQKVPVLTEDL----SDRADA 164
Cdd:PRK10955  80 RGSELDRVL-GLELGADDYLPKPFNDRELVARIRAILR----------RSHWSeqqQNNDNGSPTLEVDAlslnPGRQEA 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491114826 165 qAFNSHYEQLTNRELEILNLVAQGLSN---RE-IAEQLFVSRYT-----VESHIKHIYRKL 216
Cdd:PRK10955 149 -SFDGQTLELTGTEFTLLYLLAQHLGQvvsREhLSQEVLGKRLTpfdraIDMHISNLRRKL 208
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 12-107 3.82e-07

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 47.49  E-value: 3.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYE---VDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMIS 77

                         90
                 ....*....|....*.
gi 491114826  92 AWSTQDSLFSAIQAGA 107
Cdd:cd17550   78 GHGTIETAVKATKLGA 93
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 12-121 4.89e-07

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 47.20  E-value: 4.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddMLFfVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17555    3 ILVIDDDEVVRESIAAYLEDSGFQ--VLQ-AADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVS 79

                         90       100       110
                 ....*....|....*....|....*....|
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEII 121
Cdd:cd17555   80 GAGVMSDAVEALRLGAWDYLTKPIEDLAVL 109
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 12-232 4.92e-07

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 48.80  E-value: 4.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmlffVSHL---KAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALIL 88
Cdd:PRK11083   6 ILLVEDEQAIADTLVYALQSEGFT------VEWFergLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  89 VISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAPIDPFIAREILSQISHqkvpvltedlsDRADAQ-AF 167
Cdd:PRK11083  80 FLTARSDEVDRLVGLEIGADDYVAKPFSPREVAARVRTILRRVKKFAAPSPVIRIGHFEL-----------DEPAARiSY 148

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491114826 168 NSHYEQLTNRELEILNLVAQG----LSNREIAEQLFVS------RyTVESHIKHIYRKL-SVTKRTKAVSTARTLG 232
Cdd:PRK11083 149 FGTPLTLTRYEFLLLKTLLLSpgrvFSRQQLMDIVWEDaqdsydR-TVDTHIKTLRAKLrAINPDLSPINTHRGMG 223
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 12-129 9.35e-07

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 46.59  E-value: 9.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDigyqDDMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17596    3 ILVVDDEVRSLEALRRTLEE----DFDVLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIIIS 78

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491114826  92 AWSTQDSLFSAI-QAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd17596   79 GYTDSEDIIAGInEAGIYQYLTKPWHPDQLLLTVRNAAR 117
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 12-128 9.38e-07

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 46.47  E-value: 9.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHfRDPSAL---IL 88
Cdd:cd17618    3 ILIVEDEPAIREMIAFNLERAGFD---VVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLK-RDEMTRdipII 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 491114826  89 VISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd17618   79 MLTARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 13-129 1.44e-06

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 45.67  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  13 LIVEDEPIIQSRLRKILHDIGYQDDMLFFVSH-LKAAMTCIEDhpiaLALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEgLEYALSGIYD----LIILDIMLPGMDGLEVLKSLREEGIETPVLLLT 76

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd17625   77 ALDAVEDRVKGLDLGADDYLPKPFSLAELLARIRALLR 114
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
12-232 2.37e-06

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 47.02  E-value: 2.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDdmlFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLH----FRDPSALI 87
Cdd:PRK10161   5 ILVVEDEAPIREMVCFVLEQNGFQP---VEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKresmTRDIPVVM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  88 LviSAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRggaPIDPFIAREI-------LSQISHQkvpVLT-EDLS 159
Cdd:PRK10161  82 L--TARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMR---RISPMAVEEViemqglsLDPTSHR---VMAgEEPL 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491114826 160 DRADAQ-----AFNSHYEQLTNRElEILNLVAqglsnreiAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTLG 232
Cdd:PRK10161 154 EMGPTEfkllhFFMTHPERVYSRE-QLLNHVW--------GTNVYVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTG 222
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 10-124 2.80e-06

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 45.10  E-value: 2.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  10 VPVLIVEDEPIIQSRLRKILHDIGYQddMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPsALILV 89
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGYE--VVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVL 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491114826  90 ISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAI 124
Cdd:cd19932   78 LTAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAI 112
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 12-127 2.92e-06

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 44.84  E-value: 2.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGyQDDMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHP-DIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVT 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491114826  92 AWstqDSLfsAIQA---GATGYVLKERDDAEIIIAIRSI 127
Cdd:cd17532   80 AY---DEY--AVEAfelNAVDYLLKPFSEERLAEALAKL 113
PRK10766 PRK10766
two-component system response regulator TorR;
12-128 3.13e-06

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 46.57  E-value: 3.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmlFFVSHLKAAMTCI-EDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVI 90
Cdd:PRK10766   5 ILVVEDEPVTRARLQGYFEQEGYT----VSEAASGAGMREImQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIILVT 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  91 SAWSTQDSLFsAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:PRK10766  81 GRTDSIDRIV-GLEMGADDYVTKPLELRELLVRVKNLL 117
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 12-91 3.55e-06

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 44.26  E-value: 3.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHP-IALALVDLGLPDG-NGKELIEQLHFRDPSALILV 89
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYT---VLEAASGDEALDLLESGPdIDLLVTDVIMPGGmNGSQLAEEARRRRPDLKVLL 77


                 ..
gi 491114826  90 IS 91
Cdd:cd18161   78 TS 79
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 12-128 4.96e-06

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 44.26  E-value: 4.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHdigyQDDMLFFV----SHLKAAMTCIEDHPiALALVDLGLPDGNGKELIEQLHFRDPSALI 87
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIE----LDPDFTVVgeasSGEEGIELAERLDP-DLILLDLNMKGMSGLDTLKALREEGVSARI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 491114826  88 LVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd19931   76 VILTVSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQAA 116
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 12-113 6.34e-06

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 43.51  E-value: 6.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQ----DDMLffvshlkAAMTCIEDHPIALALVDLGLPDGNGKELIEQL----HFRDP 83
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLEKQGFRvvviDDPL-------RALTTLLNSKPDLILIDIDMPDLDGYELCSLLrkssALKDT 73

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491114826  84 SALILvisawSTQDSLFSAIQA---GATGYVLK 113
Cdd:cd17602   74 PIIML-----TGKDGLVDRIRAkmaGASGYLTK 101
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 11-216 6.49e-06

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 45.83  E-value: 6.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  11 PVLIVEDEPIIQSRLRKILHDIGYQDDMLffvSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHfRDPSALILVI 90
Cdd:PRK10710  12 RILIVEDEPKLGQLLIDYLQAASYATTLL---SHGDEVLPYVRQTPPDLILLDLMLPGTDGLTLCREIR-RFSDIPIVMV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  91 SAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL-RGGAPIDPFIAREILSQIshqkvpvltedlsdrADAQAFNS 169
Cdd:PRK10710  88 TAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILrRCKPQRELQQQDAESPLI---------------IDESRFQA 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826 170 HYEQ----LTNRELEILNLVAQG----LSNREIAEQLF-----VSRYTVESHIKHIYRKL 216
Cdd:PRK10710 153 SWRGkmldLTPAEFRLLKTLSHEpgkvFSREQLLNHLYddyrvVTDRTIDSHIKNLRRKL 212
dpiA PRK10046
two-component response regulator DpiA; Provisional
 9-113 7.39e-06

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 45.39  E-value: 7.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826   9 PVPVLIVEDE-PIIQSRLRKILHDIGYqdDMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQL-HFRDPSAL 86
Cdd:PRK10046   4 PLTLLIVEDEtPLAEMHAEYIRHIPGF--SQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELvQAHYPGDV 81

                         90       100
                 ....*....|....*....|....*..
gi 491114826  87 ILVISAwSTQDSLFSAIQAGATGYVLK 113
Cdd:PRK10046  82 VFTTAA-SDMETVSEAVRCGVFDYLIK 107
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 12-128 1.04e-05

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 43.31  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDdmlFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17553    3 ILIVDDQYGIRILLNEVFNKEGYQT---FQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMT 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd17553   80 AYGELDMIQESKELGALTHFAKPFDIDEIRDAVKKYL 116
fixJ PRK09390
response regulator FixJ; Provisional
 63-220 1.19e-05

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 44.61  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  63 DLGLPDGNGKELIEQLHFRDPSALILVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAPIDPfiarei 142
Cdd:PRK09390  54 DVRMPGIDGIELLRRLKARGSPLPVIVMTGHGDVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAPEAAK------ 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491114826 143 lsqishqkvpvltedlsDRADAQAFNSHYEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVEshikhIYRKLSVTK 220
Cdd:PRK09390 128 -----------------SEAVAADIRARIASLSERERQVMDGLVAGLSNKVIARDLDISPRTVE-----VYRANVMTK 183
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 12-113 2.03e-05

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 42.11  E-value: 2.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmlffVSHLKAAMTC---IEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALIL 88
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGYE------VRTTGNAATLwrwVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPII 74

                         90       100
                 ....*....|....*....|....*...
gi 491114826  89 VISAwstQDSLFSAIQA---GATGYVLK 113
Cdd:cd19928   75 VMSA---QNTLMTAVKAaerGAFEYLPK 99
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 12-67 3.76e-05

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 40.24  E-value: 3.76e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 491114826    12 VLIVEDEPIIQSRLRKILHDIGYQDDmlfFVSHLKAAMTCIEDHPIALALVDLGLP 67
Cdd:smart00448   3 ILVVDDDPLLRELLKALLEKEGYEVD---EATDGEEALELLKEEKPDLILLDIMMP 55
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 12-129 3.97e-05

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 41.87  E-value: 3.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILhdiGYQDDM--LFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILV 89
Cdd:cd19930    1 VLIAEDQEMVRGALAALL---ELEDDLevVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 491114826  90 ISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd19930   78 VTTFGRPGYFRRALAAGVDGYVLKDRPIEELADAIRTVHA 117
PRK15479 PRK15479
transcriptional regulator TctD;
12-232 4.89e-05

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 43.17  E-value: 4.89e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMlffVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:PRK15479   3 LLLAEDNRELAHWLEKALVQNGFAVDC---VFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAPIDPFIAReiLSQISHQkvpvltedlsdraDAQAF--NS 169
Cdd:PRK15479  80 ARSAVADRVKGLNVGADDYLPKPFELEELDARLRALLRRSAGQVQEVQQ--LGELIFH-------------DEGYFllQG 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491114826 170 HYEQLTNRELEILNLVAQ----GLSNREIAEQLF-----VSRYTVESHIKHIYRKLSVTKrtKAVSTARTLG 232
Cdd:PRK15479 145 QPLALTPREQALLTVLMYrrtrPVSRQQLFEQVFslndeVSPESIELYIHRLRKKLQGSD--VRITTLRGLG 214
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 12-128 5.43e-05

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 41.54  E-value: 5.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmlffVSHL---KAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALIL 88
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQGYK------VQVArngREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDPDLKDIP 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491114826  89 VI--SAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd17598   75 VIllTTLSDPRDVIRGLECGADNFITKPYDEKYLLSRIKYIL 116
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 10-113 5.48e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 41.55  E-value: 5.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  10 VPVLIVEDEPIIQSRLRKILHDIGYQD-----DMLFFVSHLKAAMtciedhpIALALVDLGLPDGNGKELIEQLhfRDPS 84
Cdd:cd19923    1 MKVLVVDDFSTMRRIIKNLLKELGFNNveeaeDGVDALEKLKAGG-------FDFVITDWNMPNMDGLELLKTI--RADG 71

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491114826  85 AL----ILVISAWSTQDSLFSAIQAGATGYVLK 113
Cdd:cd19923   72 ALshlpVLMVTAEAKKENVIAAAQAGVNNYIVK 104
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 12-129 7.31e-05

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 40.83  E-value: 7.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMlffVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVET---AVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLT 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd17627   78 ARDSVSDRVAGLDAGADDYLVKPFALEELLARVRALLR 115
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 12-129 1.35e-04

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 40.41  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYqdDMLFFVSHLKAAMTCIEDHPIALALvDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17615    2 VLVVDDEPNITELLSMALRYEGW--DVETAADGAEALAAAREFRPDAVVL-DIMLPDMDGLEVLRRLRADGPDVPVLFLT 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd17615   79 AKDSVEDRIAGLTAGGDDYVTKPFSLEEVVARLRALLR 116
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 107-216 1.60e-04

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 41.01  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  107 ATGYVlKERDDAEIIIA--------IRSILRGGAPIDPFIAR----EILSQISHQKV--PVLTEDLSDRADAQAFNSHYE 172
Cdd:TIGR02985  18 ARRYV-KDEEDAEDIVQdvflklweNRETLEISESIKAYLFTivknRCLNYLRHKQVeeKYQEELAEIEERELSEADPEE 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491114826  173 QLTNRELE--ILNLVA---------------QGLSNREIAEQLFVSRYTVESHIKHIYRKL 216
Cdd:TIGR02985  97 ELEAKELEeiIEEAIEklpeqcreifilsrfEGLSNKEIAEELGISVKTVEYHITKALKFL 157
REC_1_GGDEF cd19921
first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 12-114 2.36e-04

first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the first REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381148 [Multi-domain]  Cd Length: 115  Bit Score: 39.47  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRK-ILHDIGYQDDmlfFVSHLKAAMTCIEDHP-IALALVDLGLPDG-NGKELIEQLHFRDPSaliL 88
Cdd:cd19921    2 VLIVEDSKTFSKVLKHlIAQELGLEVD---VAETLAEAKALLEEGDdYFAALVDLNLPDApNGEAVDLVLEKGIPV---I 75

                         90       100
                 ....*....|....*....|....*.
gi 491114826  89 VISAWSTQDSLFSAIQAGATGYVLKE 114
Cdd:cd19921   76 VLTGSFDEDKRETLLSKGVVDYVLKD 101
PRK13557 PRK13557
histidine kinase; Provisional
 12-88 3.53e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 41.19  E-value: 3.53e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMlffVSHLKAAMTCIEDHP-IALALVDLGLPDG-NGKELIEQLHFRDPSALIL 88
Cdd:PRK13557 418 ILIVDDRPDVAELARMILEDFGYRTLV---ASNGREALEILDSHPeVDLLFTDLIMPGGmNGVMLAREARRRQPKIKVL 493
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
 172-216 3.71e-04

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 39.64  E-value: 3.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 491114826  172 EQLTNRELEILNLVA-QGLSNREIAEQLFVSRYTVESHIKHIYRKL 216
Cdd:TIGR02937 109 EKLPEREREVLVLRYlEGLSYKEIAEILGISVGTVKRRLKRARKKL 154
RpoE COG1595
DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; ...
 156-216 3.98e-04

DNA-directed RNA polymerase specialized sigma subunit, sigma24 family [Transcription]; DNA-directed RNA polymerase specialized sigma subunit, sigma24 family is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 441203 [Multi-domain]  Cd Length: 181  Bit Score: 39.98  E-value: 3.98e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491114826 156 EDLSDRADAQAFNSHYEQLTNRELEILNLVA-QGLSNREIAEQLFVSRYTVESHIKHIYRKL 216
Cdd:COG1595  110 EALEAEELLEALLAALERLPPRQREVLVLRYlEGLSYAEIAEILGISEGTVKSRLSRARKKL 171
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 12-113 4.59e-04

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 38.78  E-value: 4.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDdmLFFVSHLKAAMTCIEDHPIALALVDLGLPDG-NGKELIEQL---HFRDPSALI 87
Cdd:cd17589    1 FLIVDDQPTFRSMLKSMLRSLGVTR--IDTASSGEEALRMCENKTYDIVLCDYNLGKGkNGQQLLEELrhkKLISPSTVF 78

                         90       100
                 ....*....|....*....|....*.
gi 491114826  88 LVISAWSTQDSLFSAIQAGATGYVLK 113
Cdd:cd17589   79 IMVTGESSRAMVLSALELEPDDYLLK 104
PRK10610 PRK10610
chemotaxis protein CheY;
13-113 5.58e-04

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 38.80  E-value: 5.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  13 LIVEDEPIIQSRLRKILHDIGYQDdmlffVSHLK---AAMTCIEDHPIALALVDLGLPDGNGKELIEQLhfRDPSAL--- 86
Cdd:PRK10610   9 LVVDDFSTMRRIVRNLLKELGFNN-----VEEAEdgvDALNKLQAGGFGFVISDWNMPNMDGLELLKTI--RADGAMsal 81

                         90       100
                 ....*....|....*....|....*...
gi 491114826  87 -ILVISAWSTQDSLFSAIQAGATGYVLK 113
Cdd:PRK10610  82 pVLMVTAEAKKENIIAAAQAGASGYVVK 109
PRK10336 PRK10336
two-component system response regulator QseB;
12-216 7.29e-04

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 39.49  E-value: 7.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDmlfFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:PRK10336   3 ILLIEDDMLIGDGIKTGLSKMGFSVD---WFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAPidpfiarEILSQISHQKVPVLTEDLSDRADAQAFNSHY 171
Cdd:PRK10336  80 ARDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNG-------QASNELRHGNVMLDPGKRIATLAGEPLTLKP 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 491114826 172 EQLTNRELEILNlVAQGLSNREIAEQLF-----VSRYTVESHIKHIYRKL 216
Cdd:PRK10336 153 KEFALLELLMRN-AGRVLPRKLIEEKLYtwdeeVTSNAVEVHVHHLRRKL 201
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 11-128 7.87e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 38.05  E-value: 7.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  11 PVLIVEDEPIIQSRLRKILHDIGYQ-----DDmlffvshlKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLhfRDPSA 85
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGYEvveaaDG--------RDALSKAQSKKFDLIITDQNMPNMDGIELIKEL--RKLPA 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 491114826  86 L----ILVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd17562   72 YkftpILMLTTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKVL 118
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 42-125 1.14e-03

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 39.82  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  42 VSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVISAWSTQDSLFSAIQAGATGYVLKERDDAEII 121
Cdd:PRK13558  37 IRDFVAARDRVEAGEIDCVVADHEPDGFDGLALLEAVRQTTAVPPVVVVPTAGDEAVARRAVDADAAAYVPAVSDDATAA 116


                 ....
gi 491114826 122 IAIR 125
Cdd:PRK13558 117 IAER 120
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 11-92 1.27e-03

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 37.52  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  11 PVLIVEDEPIIQSRLRKILHDigYQDDMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVI 90
Cdd:cd17593    2 KVLICDDSSMARKQLARALPA--DWDVEITFAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVV 79


                 ..
gi 491114826  91 SA 92
Cdd:cd17593   80 SG 81
PRK10188 PRK10188
transcriptional regulator SdiA;
173-234 1.40e-03

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 38.61  E-value: 1.40e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491114826 173 QLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSVTKRTKAVSTARTLGLL 234
Cdd:PRK10188 179 NFSKREKEILKWTAEGKTSAEIAMILSISENTVNFHQKNMQKKFNAPNKTQIACYAAATGLI 240
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 12-113 1.75e-03

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 36.72  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQL----HFRD-Psal 86
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRAAGYR---VLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLkadpATRHiP--- 74

                         90       100
                 ....*....|....*....|....*..
gi 491114826  87 ILVISAWSTQDSLFSAIQAGATGYVLK 113
Cdd:cd19920   75 VIFLTALTDTEDKVKGFELGAVDYITK 101
HTH_23 pfam13384
Homeodomain-like domain;
177-215 1.78e-03

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 35.32  E-value: 1.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 491114826  177 RELEILNLVAQGLSNREIAEQLFVSRYTVeSHIKHIYRK 215
Cdd:pfam13384   6 RRARALLLLAEGLSVKEIAELLGVSRRTV-YRWLKRYNE 43
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 12-129 1.82e-03

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 36.97  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPiiqsRLRKILHDIGYQDDM-LFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLhfRDPSAL-ILV 89
Cdd:cd17622    3 ILLVEDDP----KLARLIADFLESHGFnVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDL--RPKYQGpILL 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 491114826  90 ISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILR 129
Cdd:cd17622   77 LTALDSDIDHILGLELGADDYVVKPVEPAVLLARLRALLR 116
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 12-218 1.86e-03

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 38.28  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDdmlfFVSHLKAAMTCIEDHPIALA---LVDLGLPD---GNGKELIEQLHFRDPSA 85
Cdd:PRK10840   6 VIIADDHPIVLFGIRKSLEQIEWVN----VVGEFEDSTALINNLPKLDAhvlITDLSMPGdkyGDGITLIKYIKRHFPSL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  86 LILVISAWSTQDSLFSAIQAGATGYVLKErddaeiiiairsilrgGAPIDPFIAREILSQiSHQKVPVLTEDLSDRADAQ 165
Cdd:PRK10840  82 SIIVLTMNNNPAILSAVLDLDIEGIVLKQ----------------GAPTDLPKALAALQK-GKKFTPESVSRLLEKISAG 144

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 491114826 166 AFNShyEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLSV 218
Cdd:PRK10840 145 GYGD--KRLSPKESEVLRLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLGV 195
PRK08295 PRK08295
RNA polymerase sporulation sigma factor SigH;
140-217 2.15e-03

RNA polymerase sporulation sigma factor SigH;


Pssm-ID: 181361 [Multi-domain]  Cd Length: 208  Bit Score: 37.97  E-value: 2.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491114826 140 REILSQISHQKVPVLTEDLSDRADAQAFNSH-YEQLTNRELEILNLVAQGLSNREIAEQLFVSRYTVESHIKHIYRKLS 217
Cdd:PRK08295 121 RTLLDVISEAKVTDPEELIISKEELEDIEEKiEELLSELEKEVLELYLDGKSYQEIAEELNRHVKSIDNALQRVKRKLE 199
PRK10693 PRK10693
two-component system response regulator RssB;
48-113 3.54e-03

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 37.66  E-value: 3.54e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491114826  48 AMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVISAWSTQDSLFSAIQAGATGYVLK 113
Cdd:PRK10693   9 ALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMADIAKALRLGVQDVLLK 74
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 152-210 3.64e-03

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 37.91  E-value: 3.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491114826 152 PVLTEDLSDRADAQAFNSHYEQLTNReLEILNLVAQGLSNREIAEQLFVSRYTVESHIK 210
Cdd:COG3415    3 LTLTEEERRDLEKLLRKTKDAREARR-LRAVLLLAEGLSVREIAERLGVSRSTVYRWLK 60
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 12-92 4.09e-03

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 36.27  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGyQDDMLFFvSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd17530    3 VLVLDDDPFQCMMAATILEDLG-PGNVDEA-DDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILMS 80


                 .
gi 491114826  92 A 92
Cdd:cd17530   81 G 81
PRK13435 PRK13435
response regulator; Provisional
 9-69 4.26e-03

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 36.57  E-value: 4.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491114826   9 PVPVLIVEDEPIIQSRLRKILHDIGYQDdmlffvshLKAAMTCIEDHPIA------LALVDLGLPDG 69
Cdd:PRK13435   5 QLKVLIVEDEALIALELEKLVEEAGHEV--------VGIAMSSEQAIALGrrrqpdVALVDVHLADG 63
Sigma70_r4_2 pfam08281
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
 172-216 4.33e-03

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.


Pssm-ID: 400535 [Multi-domain]  Cd Length: 54  Bit Score: 34.35  E-value: 4.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 491114826  172 EQLTNRELEILNL-VAQGLSNREIAEQLFVSRYTVESHIKHIYRKL 216
Cdd:pfam08281   9 EELPPRQREVFLLrYLEGLSYAEIAELLGISEGTVKSRLSRARKKL 54
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 12-128 4.35e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 35.91  E-value: 4.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLhfRDPSAL-ILVI 90
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLRGEGFD---PAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQI--RAESGVpIVML 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491114826  91 SAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd17626   78 TAKSDTVDVVLGLESGADDYVAKPFKPKELVARIRARL 115
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 12-135 5.08e-03

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 37.58  E-value: 5.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCI-EDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVI 90
Cdd:PRK11466 684 LLLIEDNPLTQRITAEMLNTSGAQ---VVAVGNAAQALETLqNSEPFAAALVDFDLPDYDGITLARQLAQQYPSLVLIGF 760

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 491114826  91 SAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSILRGGAPID 135
Cdd:PRK11466 761 SAHVIDETLRQRTSSLFRGIIPKPVPREVLGQLLAHYLQLQVNND 805
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 12-124 5.41e-03

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 35.51  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVI- 90
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAE---VTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLANTPAIa 77

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491114826  91 -SAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAI 124
Cdd:cd17580   78 lTGYGQPEDRERALEAGFDAHLVKPVDPDELIELI 112
PRK11173 PRK11173
two-component response regulator; Provisional
 12-128 7.22e-03

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 36.53  E-value: 7.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYqddMLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:PRK11173   6 ILIVEDELVTRNTLKSIFEAEGY---DVFEATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQANVALMFLTG 82

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491114826  92 AWSTQDSLFsAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:PRK11173  83 RDNEVDKIL-GLEIGADDYITKPFNPRELTIRARNLL 118
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 12-113 7.39e-03

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 35.11  E-value: 7.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQDDMlffVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSALILVIS 91
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEGYAVDV---AYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLT 77

                         90       100
                 ....*....|....*....|..
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLK 113
Cdd:cd19935   78 ARDSVEDRVKGLDLGADDYLVK 99
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 59-128 7.62e-03

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 35.08  E-value: 7.62e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  59 LALVDLGLPDGNGKELIEQLHFRDPSALILVISAWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd17616   45 IILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLADIEDKVKGLGFGADDYMTKPFHKDELVARIHAIV 114
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 12-128 7.88e-03

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 35.34  E-value: 7.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826  12 VLIVEDEPIIQSRLRKILHDIGYQddmLFFVSHLKAAMTCIEDHPIALALVDLGLPDGNGKELIEQLHFRDPSAlILVIS 91
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWGYE---VVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISNVP-IIFIS 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491114826  92 AWSTQDSLFSAIQAGATGYVLKERDDAEIIIAIRSIL 128
Cdd:cd18159   77 SRDDNMDQVMAINMGGDDYITKPFDLDVLLAKIKAIL 113
COG1356 COG1356
Transcriptional regulator [Transcription];
174-205 9.24e-03

Transcriptional regulator [Transcription];


Pssm-ID: 440967 [Multi-domain]  Cd Length: 139  Bit Score: 35.21  E-value: 9.24e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 491114826 174 LTNRELEILNLVAQGLSNREIAEQLFVSRYTV 205
Cdd:COG1356    9 LTRRQAEVLALRERGLTQQEIADILGTSRANV 40
PRK06930 PRK06930
positive control sigma-like factor; Validated
 137-217 9.58e-03

positive control sigma-like factor; Validated


Pssm-ID: 180757 [Multi-domain]  Cd Length: 170  Bit Score: 35.86  E-value: 9.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491114826 137 FIAREILSQISHQKVPVLTEDLSDR-ADAQAFnshyeqLTNRELEILNL-VAQGLSNREIAEQLFVSRYTVESHIKHIYR 214
Cdd:PRK06930  83 FRSMEDLEWDIEEPESVISEWDKIRiEDALSV------LTEREKEVYLMhRGYGLSYSEIADYLNIKKSTVQSMIERAEK 156


                 ...
gi 491114826 215 KLS 217
Cdd:PRK06930 157 KIA 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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