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Conserved domains on  [gi|491115367|ref|WP_004973824|]
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MULTISPECIES: carboxymuconolactone decarboxylase family protein [Acinetobacter]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 10001777)

carboxymuconolactone decarboxylase (CMD) family protein similar to alkyl hydroperoxide reductase AhpD, which is required for the reduction of the AhpC active site cysteine residues to regenerate its enzyme activity; carboxymuconolactone d

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4000771

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 2-110 1.17e-31

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


:

Pssm-ID: 440364  Cd Length: 114  Bit Score: 107.73  E-value: 1.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491115367   2 KYTELTAEISSNIKSIKEQSPDLLKSFNALSQVAMKDGVIDAKTKEFIALAIGVAQRCDGCIGFHVRTLVKMGMTFEELN 81
Cdd:COG0599    3 VLKEVEEYVPRALEALAEFAPEFAEAFEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIA 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 491115367  82 EILGIAVYMGGGPSLMYAANAV-AAFKEFS 110
Cdd:COG0599   83 EALLVAAVYAGFPAALNALRAAlEVLEELG 112
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 2-110 1.17e-31

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 107.73  E-value: 1.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491115367   2 KYTELTAEISSNIKSIKEQSPDLLKSFNALSQVAMKDGVIDAKTKEFIALAIGVAQRCDGCIGFHVRTLVKMGMTFEELN 81
Cdd:COG0599    3 VLKEVEEYVPRALEALAEFAPEFAEAFEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIA 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 491115367  82 EILGIAVYMGGGPSLMYAANAV-AAFKEFS 110
Cdd:COG0599   83 EALLVAAVYAGFPAALNALRAAlEVLEELG 112
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 22-105 4.75e-22

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 82.36  E-value: 4.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491115367   22 PDLLKSFNALSQVAMKDGVIDAKTKEFIALAIGVAQRCDGCIGFHVRTLVKMGMTFEELNEILGIAVYMGGGPSLMYAAN 101
Cdd:pfam02627   1 PELLAALTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80


                  ....
gi 491115367  102 AVAA 105
Cdd:pfam02627  81 AAEE 84
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 39-87 2.71e-09

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 48.91  E-value: 2.71e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 491115367   39 GVIDAKTKEFIALAIGVAQRCDGCIGFHVRTLVKMGMTFEELNEILGIA 87
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWA 49
D-aminoacylase cd01297
D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of ...
 43-87 2.29e-03

D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics.


Pssm-ID: 238622 [Multi-domain]  Cd Length: 415  Bit Score: 36.12  E-value: 2.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 491115367  43 AKTKEFIALAiGVAQRCDGCIGFHVRTLVKmgMTFEELNEILGIA 87
Cdd:cd01297  196 AGTAELVALA-RVAARYGGVYQTHVRYEGD--SILEALDELLRLG 237
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 2-110 1.17e-31

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 107.73  E-value: 1.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491115367   2 KYTELTAEISSNIKSIKEQSPDLLKSFNALSQVAMKDGVIDAKTKEFIALAIGVAQRCDGCIGFHVRTLVKMGMTFEELN 81
Cdd:COG0599    3 VLKEVEEYVPRALEALAEFAPEFAEAFEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIA 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 491115367  82 EILGIAVYMGGGPSLMYAANAV-AAFKEFS 110
Cdd:COG0599   83 EALLVAAVYAGFPAALNALRAAlEVLEELG 112
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 22-105 4.75e-22

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 82.36  E-value: 4.75e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491115367   22 PDLLKSFNALSQVAMKDGVIDAKTKEFIALAIGVAQRCDGCIGFHVRTLVKMGMTFEELNEILGIAVYMGGGPSLMYAAN 101
Cdd:pfam02627   1 PELLAALTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80


                  ....
gi 491115367  102 AVAA 105
Cdd:pfam02627  81 AAEE 84
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 21-83 1.25e-10

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 54.50  E-value: 1.25e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491115367  21 SPDLLKSFNALSQVAMKDGVIDAKTKEFIALAIGVAQRCDGCIGFHVRTLVKMGMTFEELNEI 83
Cdd:COG2128    2 SPELLKAFLALSGALMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDAL 64
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 39-87 2.71e-09

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 48.91  E-value: 2.71e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 491115367   39 GVIDAKTKEFIALAIGVAQRCDGCIGFHVRTLVKMGMTFEELNEILGIA 87
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWA 49
D-aminoacylase cd01297
D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of ...
 43-87 2.29e-03

D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics.


Pssm-ID: 238622 [Multi-domain]  Cd Length: 415  Bit Score: 36.12  E-value: 2.29e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 491115367  43 AKTKEFIALAiGVAQRCDGCIGFHVRTLVKmgMTFEELNEILGIA 87
Cdd:cd01297  196 AGTAELVALA-RVAARYGGVYQTHVRYEGD--SILEALDELLRLG 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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