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Conserved domains on  [gi|491118303|ref|WP_004976754|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Acinetobacter]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
22-151 6.56e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.41  E-value: 6.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491118303  22 YYWVTQVHAQYVQNVDQALKKYGLDNSRRRILLALRSKAHASVSDLSDMVVSKMSTTTKIVYRLKDEGLVETYSCDDDAR 101
Cdd:COG1846   13 GLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRR 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 491118303 102 ITRVVLTEKGNEMTNKINDLTSVVLEQSFDGLTPLQIEKMMESLRHIFNN 151
Cdd:COG1846   93 AVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
22-151 6.56e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.41  E-value: 6.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491118303  22 YYWVTQVHAQYVQNVDQALKKYGLDNSRRRILLALRSKAHASVSDLSDMVVSKMSTTTKIVYRLKDEGLVETYSCDDDAR 101
Cdd:COG1846   13 GLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRR 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 491118303 102 ITRVVLTEKGNEMTNKINDLTSVVLEQSFDGLTPLQIEKMMESLRHIFNN 151
Cdd:COG1846   93 AVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
38-138 1.55e-13

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 62.61  E-value: 1.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491118303    38 QALKKYGLDNSRRRILLALRSKAHASVSDLSDMVVSKMSTTTKIVYRLKDEGLVETYSCDDDARITRVVLTEKGNEMTNK 117
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 491118303   118 INDLTSVVLEQSFDGLTPLQI 138
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 43-102 3.27e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 44.89  E-value: 3.27e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491118303   43 YGLDNSRRRILLALRSKAHASVSDLSD-MVVSKmSTTTKIVYRLKDEGLVETYSCDDDARI 102
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARrLGISK-QTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 85-141 3.90e-05

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 41.14  E-value: 3.90e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491118303  85 LKDEGLVETYSCDDDARITRVVLTEKGNEMTNKINDLTSVVLEQSFDGLTPLQIEKM 141
Cdd:PRK03573  70 LEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIEQL 126
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 46-94 1.90e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 1.90e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 491118303  46 DNSRRRILLALRSKAhASVSDLSDMV-VSKmSTTTKIVYRLKDEGLVETY 94
Cdd:cd00090    6 DPTRLRILRLLLEGP-LTVSELAERLgLSQ-STVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
22-151 6.56e-22

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 85.41  E-value: 6.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491118303  22 YYWVTQVHAQYVQNVDQALKKYGLDNSRRRILLALRSKAHASVSDLSDMVVSKMSTTTKIVYRLKDEGLVETYSCDDDAR 101
Cdd:COG1846   13 GLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRR 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 491118303 102 ITRVVLTEKGNEMTNKINDLTSVVLEQSFDGLTPLQIEKMMESLRHIFNN 151
Cdd:COG1846   93 AVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
38-138 1.55e-13

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 62.61  E-value: 1.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491118303    38 QALKKYGLDNSRRRILLALRSKAHASVSDLSDMVVSKMSTTTKIVYRLKDEGLVETYSCDDDARITRVVLTEKGNEMTNK 117
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 491118303   118 INDLTSVVLEQSFDGLTPLQI 138
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 43-102 3.27e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 44.89  E-value: 3.27e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491118303   43 YGLDNSRRRILLALRSKAHASVSDLSD-MVVSKmSTTTKIVYRLKDEGLVETYSCDDDARI 102
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARrLGISK-QTVSRLVKRLEAKGLVEREPSPADRRA 60
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
52-118 1.68e-05

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 42.11  E-value: 1.68e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491118303  52 ILLALRSKAHASVSDLSDMVVSKMSTTTKIVYRLKDEGLV--ETYScdddaritRVVLTEKGNEMTNKI 118
Cdd:COG1321   15 IYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVeyEPYG--------GITLTEEGRELALRI 75
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 85-141 3.90e-05

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 41.14  E-value: 3.90e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491118303  85 LKDEGLVETYSCDDDARITRVVLTEKGNEMTNKINDLTSVVLEQSFDGLTPLQIEKM 141
Cdd:PRK03573  70 LEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIEQL 126
PRK13777 PRK13777
HTH-type transcriptional regulator Hpr;
38-149 1.31e-04

HTH-type transcriptional regulator Hpr;


Pssm-ID: 237501  Cd Length: 185  Bit Score: 40.03  E-value: 1.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491118303  38 QALKKYGLDNSRRRILLALRSKAHASVSDLSDMVVSKMSTTTKIVYRLKDEGLVETYSCDDDARITRVVLTEKGNEMTNK 117
Cdd:PRK13777  36 QWIKPYDLNINEHHILWIAYHLKGASISEIAKFGVMHVSTAFNFSKKLEERGYLTFSKKEDDKRNTYIELTEKGEELLLE 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 491118303 118 I----NDLTSVVleqsFDGLTPLQ--------IEKMMESLRHIF 149
Cdd:PRK13777 116 TmeeyDPENNSV----FNGALPLRelygkfpeFIELMAIVRNIY 155
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 18-118 1.60e-03

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 37.03  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491118303  18 EQFPYYWV------TQVHAQYVQNVDQALKKYGLDNSRRRILLALRSKAHASV--SDLSDMVVSKMSTTTKIVYRLKDEG 89
Cdd:PRK10870  20 EDFPYQEIlltrlcMHMQSKLLENRNKMLKAQGINETLFMALITLESQENHSIqpSELSCALGSSRTNATRIADELEKRG 99

                         90       100
                 ....*....|....*....|....*....
gi 491118303  90 LVETYSCDDDARITRVVLTEKGNEMTNKI 118
Cdd:PRK10870 100 WIERRESDNDRRCLHLQLTEKGHEFLREV 128
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 46-94 1.90e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 1.90e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 491118303  46 DNSRRRILLALRSKAhASVSDLSDMV-VSKmSTTTKIVYRLKDEGLVETY 94
Cdd:cd00090    6 DPTRLRILRLLLEGP-LTVSELAERLgLSQ-STVSRHLKKLEEAGLVESR 53
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
49-91 6.90e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 32.79  E-value: 6.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 491118303   49 RRRILLALRSKAHASVSDLSDMV-VSKmSTTTKIVYRLKDEGLV 91
Cdd:pfam13412   3 DRKILNLLQENPRISQRELAERLgLSP-STVNRRLKRLEEEGVI 45
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 51-103 9.07e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 32.90  E-value: 9.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 491118303   51 RILLALRSKAHASVSDLSDMVVSKMSTTTKIVYRLKDEGLVETYSCDDDARIT 103
Cdd:pfam01047   7 HILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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