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Conserved domains on  [gi|491210950|ref|WP_005069281|]
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MULTISPECIES: AraC family transcriptional regulator [Acinetobacter]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12168325)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC_binding_2 pfam14525
AraC-binding-like domain; This domain is related to the AraC ligand binding domain pfam02311.
 20-200 1.85e-22

AraC-binding-like domain; This domain is related to the AraC ligand binding domain pfam02311.


:

Pssm-ID: 434015  Cd Length: 173  Bit Score: 91.98  E-value: 1.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950   20 AQNLMSTICGEHRLDTIYKDTLDFHYDGMRLpnKKMAIGTISYGANVAINISNLKA-YSISLPIQGRQALNIRGAHYQSD 98
Cdd:pfam14525   1 WREAVSRAFGPHRLRPLGPDRFDARLRGVRL--GGLSLGRLRYGAAVHIRPPELDDfYLLQLPLSGSAEIEQGGREVVLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950   99 ENRGLIVSNNDQQDLIIDKDCRKFQVVIPersmqivLADLLNKPIETPIIFNPEMHLDSEQLiGAWWKNIQNFL-QLKSQ 177
Cdd:pfam14525  79 PGDAVLLDPGRPYRLRWSEDCEQLVLRIP-------LRALLGRPLRRPLRFAPRLDLDSGLG-ALWLRLLRLLAaELAAL 150

                         170       180
                  ....*....|....*....|...
gi 491210950  178 YSNFYGLQMLSEDYENFVIKALL 200
Cdd:pfam14525 151 GPALASSPLVAAQLEELLASLLL 173
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
237-324 6.08e-20

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.60  E-value: 6.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950   237 EICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTGadkkVSISKLAYDWGFNHLSRFSQEYREEF 316
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTD----LSVTEIALRVGFSSQSYFSRAFKKLF 76


                   ....*...
gi 491210950   317 GENPSETK 324
Cdd:smart00342  77 GVTPSEYR 84
 
Name Accession Description Interval E-value
AraC_binding_2 pfam14525
AraC-binding-like domain; This domain is related to the AraC ligand binding domain pfam02311.
 20-200 1.85e-22

AraC-binding-like domain; This domain is related to the AraC ligand binding domain pfam02311.


Pssm-ID: 434015  Cd Length: 173  Bit Score: 91.98  E-value: 1.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950   20 AQNLMSTICGEHRLDTIYKDTLDFHYDGMRLpnKKMAIGTISYGANVAINISNLKA-YSISLPIQGRQALNIRGAHYQSD 98
Cdd:pfam14525   1 WREAVSRAFGPHRLRPLGPDRFDARLRGVRL--GGLSLGRLRYGAAVHIRPPELDDfYLLQLPLSGSAEIEQGGREVVLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950   99 ENRGLIVSNNDQQDLIIDKDCRKFQVVIPersmqivLADLLNKPIETPIIFNPEMHLDSEQLiGAWWKNIQNFL-QLKSQ 177
Cdd:pfam14525  79 PGDAVLLDPGRPYRLRWSEDCEQLVLRIP-------LRALLGRPLRRPLRFAPRLDLDSGLG-ALWLRLLRLLAaELAAL 150

                         170       180
                  ....*....|....*....|...
gi 491210950  178 YSNFYGLQMLSEDYENFVIKALL 200
Cdd:pfam14525 151 GPALASSPLVAAQLEELLASLLL 173
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
237-324 6.08e-20

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.60  E-value: 6.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950   237 EICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTGadkkVSISKLAYDWGFNHLSRFSQEYREEF 316
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTD----LSVTEIALRVGFSSQSYFSRAFKKLF 76


                   ....*...
gi 491210950   317 GENPSETK 324
Cdd:smart00342  77 GVTPSEYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
245-324 3.08e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 78.02  E-value: 3.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950  245 RLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTGADkkvSISKLAYDWGFNHLSRFSQEYREEFGENPSETK 324
Cdd:pfam12833   3 AALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDTGL---SVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
210-322 5.58e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.44  E-value: 5.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950 210 ALKSLSHQDEPAYIRKVRNFIIEHAHEEICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTgadk 289
Cdd:COG2207  141 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAET---- 216

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491210950 290 KVSISKLAYDWGFNHLSRFSQEYREEFGENPSE 322
Cdd:COG2207  217 DLSISEIAYELGFSSQSHFSRAFKKRFGVTPSE 249
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
213-323 8.54e-11

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 62.24  E-value: 8.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950 213 SLSHQDEPAYIRKVRNFIIEHAHEEICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTGADKKvS 292
Cdd:PRK10130 232 SISHQSYRRLLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELISPWSQST-T 310

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491210950 293 ISKLAYDWGFNHLSRFSQEYREEFGENPSET 323
Cdd:PRK10130 311 VKDAAMQWGFWHLGQFATDYQQLFAEKPSLT 341
 
Name Accession Description Interval E-value
AraC_binding_2 pfam14525
AraC-binding-like domain; This domain is related to the AraC ligand binding domain pfam02311.
 20-200 1.85e-22

AraC-binding-like domain; This domain is related to the AraC ligand binding domain pfam02311.


Pssm-ID: 434015  Cd Length: 173  Bit Score: 91.98  E-value: 1.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950   20 AQNLMSTICGEHRLDTIYKDTLDFHYDGMRLpnKKMAIGTISYGANVAINISNLKA-YSISLPIQGRQALNIRGAHYQSD 98
Cdd:pfam14525   1 WREAVSRAFGPHRLRPLGPDRFDARLRGVRL--GGLSLGRLRYGAAVHIRPPELDDfYLLQLPLSGSAEIEQGGREVVLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950   99 ENRGLIVSNNDQQDLIIDKDCRKFQVVIPersmqivLADLLNKPIETPIIFNPEMHLDSEQLiGAWWKNIQNFL-QLKSQ 177
Cdd:pfam14525  79 PGDAVLLDPGRPYRLRWSEDCEQLVLRIP-------LRALLGRPLRRPLRFAPRLDLDSGLG-ALWLRLLRLLAaELAAL 150

                         170       180
                  ....*....|....*....|...
gi 491210950  178 YSNFYGLQMLSEDYENFVIKALL 200
Cdd:pfam14525 151 GPALASSPLVAAQLEELLASLLL 173
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
237-324 6.08e-20

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 82.60  E-value: 6.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950   237 EICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTGadkkVSISKLAYDWGFNHLSRFSQEYREEF 316
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTD----LSVTEIALRVGFSSQSYFSRAFKKLF 76


                   ....*...
gi 491210950   317 GENPSETK 324
Cdd:smart00342  77 GVTPSEYR 84
HTH_18 pfam12833
Helix-turn-helix domain;
245-324 3.08e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 78.02  E-value: 3.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950  245 RLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTGADkkvSISKLAYDWGFNHLSRFSQEYREEFGENPSETK 324
Cdd:pfam12833   3 AALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDTGL---SVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
210-322 5.58e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.44  E-value: 5.58e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950 210 ALKSLSHQDEPAYIRKVRNFIIEHAHEEICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTgadk 289
Cdd:COG2207  141 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAET---- 216

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491210950 290 KVSISKLAYDWGFNHLSRFSQEYREEFGENPSE 322
Cdd:COG2207  217 DLSISEIAYELGFSSQSHFSRAFKKRFGVTPSE 249
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 207-322 1.88e-11

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 64.02  E-value: 1.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950 207 YSEALKSLSHQDEPayIRKVRNFIIEHAHEEICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTG 286
Cdd:COG4977  198 FSPLLVPLGHRDPR--LARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTD 275

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491210950 287 AdkkvSISKLAYDWGFNHLSRFSQEYREEFGENPSE 322
Cdd:COG4977  276 L----SIEEIAAACGFGSASHFRRAFRRRFGVSPSA 307
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
213-323 8.54e-11

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 62.24  E-value: 8.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950 213 SLSHQDEPAYIRKVRNFIIEHAHEEICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTGADKKvS 292
Cdd:PRK10130 232 SISHQSYRRLLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELISPWSQST-T 310

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491210950 293 ISKLAYDWGFNHLSRFSQEYREEFGENPSET 323
Cdd:PRK10130 311 VKDAAMQWGFWHLGQFATDYQQLFAEKPSLT 341
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 216-322 5.14e-10

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 59.68  E-value: 5.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950 216 HQDEPAYIRKVRNFIIEHAHEEICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTGadkkvSISK 295
Cdd:COG2169   79 SPPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGL-----SVTD 153

                         90       100
                 ....*....|....*....|....*..
gi 491210950 296 LAYDWGFNHLSRFSQEYREEFGENPSE 322
Cdd:COG2169  154 AAYAAGFGSLSRFYEAFKKLLGMTPSA 180
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
232-322 4.17e-07

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 50.45  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950 232 EHAHEEICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTgaDKkvSISKLAYDWGFNHLSRFSQE 311
Cdd:PRK13503 182 DHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHS--DA--SVTDIAYRCGFGDSNHFSTL 257

                         90
                 ....*....|.
gi 491210950 312 YREEFGENPSE 322
Cdd:PRK13503 258 FRREFSWSPRD 268
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 224-322 2.07e-05

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 45.41  E-value: 2.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950 224 RKVRNFIIEHAHEEICA-EDLQRLAGVSKSKLYDEFQQYyGTSPMSYLKKYRLQQIYKILSTtgADKKVSISKLAYDWGF 302
Cdd:PRK09685 200 QKVVALIDQSIQEEILRpEWIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCADDLRP--AADDEKITSIAYKWGF 276

                         90       100
                 ....*....|....*....|
gi 491210950 303 NHLSRFSQEYREEFGENPSE 322
Cdd:PRK09685 277 SDSSHFSTAFKQRFGVSPGE 296
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 230-271 2.51e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 35.21  E-value: 2.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 491210950  230 IIEHAHEEICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLK 271
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
223-322 9.73e-03

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 37.26  E-value: 9.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491210950 223 IRKVRNFIIEHAHEEICAEDLQRLAGVSKSKLYDEFQQYYGTSPMSYLKKYRLQQIYKILSTTGAdkkvSISKLAYDWGF 302
Cdd:PRK10572 185 VREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRM----PIATIGRNVGY 260

                         90       100
                 ....*....|....*....|
gi 491210950 303 NHLSRFSQEYREEFGENPSE 322
Cdd:PRK10572 261 DDQLYFSRVFKKCTGASPSE 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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