|
Name |
Accession |
Description |
Interval |
E-value |
| Lig |
COG0272 |
NAD-dependent DNA ligase [Replication, recombination and repair]; |
1-671 |
0e+00 |
|
NAD-dependent DNA ligase [Replication, recombination and repair];
Pssm-ID: 440042 [Multi-domain] Cd Length: 668 Bit Score: 1122.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 1 MATTSVIEQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVP 80
Cdd:COG0272 1 MTPEEAKERIEELREELRRHNYRYYVLDAPEISDAEYDALLRELQALEAEHPELITPDSPTQRVGGAPLEGFAKVRHAVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 81 MLSLGNVFNQEDLFAFARRVEERLPNQKVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVL 160
Cdd:COG0272 81 MLSLDNAFSEEELRDFDRRVRKFLGDEPVEYVCELKIDGLAISLRYENGRLVRAATRGDGTVGEDVTANVRTIRSIPLRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 161 HSDHfeIPRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEpNHGLT 240
Cdd:COG0272 161 KGDD--VPEVLEVRGEVYMPKADFEALNEEREEAGEKPFANPRNAAAGSLRQLDPKITAKRPLDFFAYGLGEVE-GLLPD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 241 TMHDSLQWLTKLGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPA 320
Cdd:COG0272 238 TQSEALELLKEWGFPVNPERRVCKSIEEVLAYIEEWEEKRHSLPYEIDGVVIKVNDLALQERLGFTSRAPRWAIAYKFPA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 321 QAALTTVDQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVWPEFRPV 400
Cdd:COG0272 318 EEATTKLLDIEVQVGRTGALTPVARLEPVFVAGVTVSRATLHNEDEIERKDVRIGDTVVVRKAGDVIPEVVGVVLEKRPG 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 401 DAEVVHLPENCPVCASPVVMPEGEALARCSGGLYCAAQRIEAIRHFVSRKALDIEGLGDRWVESLLHLDLLKDVADIYHL 480
Cdd:COG0272 398 DEKPFVMPTHCPVCGSPLVREEGEAALRCTNGLSCPAQLKERLKHFASRKAMDIEGLGEKLIEQLVDAGLVKDPADLYRL 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 481 heHRETLLGIEKMGEKSVQNLIDAIEASKKTTLARFIYALGIRGVGETTARMLANTFQTLEALKAADVEALKKTPDVGDI 560
Cdd:COG0272 478 --TKEDLLGLERMGEKSAQNLLAAIEKSKKTPLARFLFALGIRHVGETTAKLLARHFGSLDALMAASEEELAAVDGIGPV 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 561 TAEWIADFFLAPHNIEVLDRLIAAGIHWDAPTAPTR--QPLNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTK 638
Cdd:COG0272 556 VAESIVEFFAEPHNRELIERLRAAGVNMEEEEAEAAadSPLAGKTFVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTD 635
|
650 660 670
....*....|....*....|....*....|...
gi 491212672 639 CVVAGEKAGSKLEKAAKLGIAVMNETDFLSLMA 671
Cdd:COG0272 636 YVVAGENAGSKLDKAEELGVPILDEAEFLELLG 668
|
|
| ligA |
PRK07956 |
NAD-dependent DNA ligase LigA; Validated |
2-671 |
0e+00 |
|
NAD-dependent DNA ligase LigA; Validated
Pssm-ID: 236137 [Multi-domain] Cd Length: 665 Bit Score: 1048.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 2 ATTSVIEQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPM 81
Cdd:PRK07956 1 TMEEAKKRIEELREELNHHAYAYYVLDAPSISDAEYDRLYRELVALEAEHPELITPDSPTQRVGGAPLDGFEKVRHLVPM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 82 LSLGNVFNQEDLFAFARRVEERLPNQKVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLH 161
Cdd:PRK07956 81 LSLDNAFSEEELRAFDKRVRKRLPDPPLTYLCELKIDGLAVSLLYENGVLVRAATRGDGTTGEDITANVRTIRSIPLRLH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 162 SDHfeiPRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEPNHGLTT 241
Cdd:PRK07956 161 GNE---PERLEVRGEVFMPKADFEALNEERREEGEKPFANPRNAAAGSLRQLDPKITAKRPLSFFAYGVGEVEGGELPDS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 242 MHDSLQWLTKLGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQ 321
Cdd:PRK07956 238 QSEALEFLKAWGFPVNPYRKLCTSIEEVLAFYEEIEEERHDLPYDIDGVVIKVDDLALQEELGFTAKAPRWAIAYKFPAE 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 322 AALTTVDQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVWPEFRPVD 401
Cdd:PRK07956 318 EATTKLLDIEVQVGRTGAVTPVARLEPVEVAGVTVSRATLHNADEIERKDIRIGDTVVVRRAGDVIPEVVGVVLEKRPGD 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 402 AEVVHLPENCPVCASPVVMPEGEALARCSGGLYCAAQRIEAIRHFVSRKALDIEGLGDRWVESLLHLDLLKDVADIYHLH 481
Cdd:PRK07956 398 EREIVMPTHCPVCGSELVRVEGEAVLRCTNGLSCPAQLKERLIHFVSRNAMDIDGLGEKIIEQLFEKGLIHDPADLFKLT 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 482 EhrETLLGIEKMGEKSVQNLIDAIEASKKTTLARFIYALGIRGVGETTARMLANTFQTLEALKAADVEALKKTPDVGDIT 561
Cdd:PRK07956 478 A--EDLLGLEGFGEKSAQNLLDAIEKSKETSLARFLYALGIRHVGEKAAKALARHFGSLEALRAASEEELAAVEGVGEVV 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 562 AEWIADFFLAPHNIEVLDRLIAAGIHWDAPTAPTrqPLNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTKCVV 641
Cdd:PRK07956 556 AQSIVEFFAVEENRELIDELLEAGVNMEYKGEEV--DLAGKTVVLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVV 633
|
650 660 670
....*....|....*....|....*....|
gi 491212672 642 AGEKAGSKLEKAAKLGIAVMNETDFLSLMA 671
Cdd:PRK07956 634 AGEAAGSKLAKAQELGIEVLDEEEFLRLLG 663
|
|
| dnlj |
TIGR00575 |
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent ... |
13-666 |
0e+00 |
|
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent DNA ligases. Functions of these proteins include DNA repair, DNA replication, and DNA recombination. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The member of this family from Treponema pallidum differs in having three rather than just one copy of the BRCT (BRCA1 C Terminus) domain (pfam00533) at the C-terminus. It is included in the seed. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273148 [Multi-domain] Cd Length: 652 Bit Score: 863.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 13 LIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPMLSLGNVFNQED 92
Cdd:TIGR00575 1 LRKLIRHHDYRYYVLDEPSISDAEYDRLYRELQELEEKHPELITPDSPTQRVGAAPLSRFPKVRHSTPMLSLDNAFDEDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 93 LFAFARRVEERLpNQKVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLHSDHFeiPRLLE 172
Cdd:TIGR00575 81 LAAFIKRIRRQL-GLKVEYVVEPKIDGLSVSLTYENGVLVRALTRGDGTVGEDVTANVRTIRSIPLRLAGDNP--PERLE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 173 VRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEPnHGLTTMHDSLQWLTKL 252
Cdd:TIGR00575 158 VRGEVFMPKEDFEALNEERREQGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAYGLGEGLE-LPDATQYEALAWLKKW 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 253 GFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQAALTTVDQIDW 332
Cdd:TIGR00575 237 GFPVSPHIRLCDSIEEVLEYYREIEEKRDSLPYEIDGVVVKVDDLALQDELGFTSKAPRWAIAYKFPAEEAQTKLLDVVV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 333 QVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVWPEFRPVDAEVVHLPENCP 412
Cdd:TIGR00575 317 QVGRTGAITPVAKLEPVFVAGTTVSRATLHNEDEIEELDIRIGDTVVVRKAGDVIPKVVRVLLEKRTGSERPIRFPTHCP 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 413 VCASPVVMPEGEALARCSgGLYCAAQRIEAIRHFVSRKALDIEGLGDRWVESLLHLDLLKDVADIYHLHEhrETLLGIEK 492
Cdd:TIGR00575 397 SCGSPLVKIEEEAVIRCP-NLNCPAQRVERIKHFASRNAMDIEGLGDKVIEQLFEKKLVRSVADLYALKK--EDLLELEG 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 493 MGEKSVQNLIDAIEASKKTTLARFIYALGIRGVGETTARMLANTFQTLEALKAADVEALKKTPDVGDITAEWIADFFLAP 572
Cdd:TIGR00575 474 FGEKSAQNLLNAIEKSKEKPLARLLFALGIRHVGEVTAKNLAKHFGTLDKLKAASLEELLSVEGVGPKVAESIVNFFHDP 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 573 HNIEVLDRLIAAGIHWDA-----PTAPTRQPLNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTKCVVAGEKAG 647
Cdd:TIGR00575 554 NNRQLIKKLEELGVEMESlpekvNAELAGSPLAGKTFVLTGTLSQMSRDEAKELLENLGGKVASSVSKKTDYVIAGEKAG 633
|
650
....*....|....*....
gi 491212672 648 SKLEKAAKLGIAVMNETDF 666
Cdd:TIGR00575 634 SKLAKAQELGIPIINEEEL 652
|
|
| LIGANc |
smart00532 |
Ligase N family; |
6-451 |
0e+00 |
|
Ligase N family;
Pssm-ID: 214709 [Multi-domain] Cd Length: 441 Bit Score: 631.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 6 VIEQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPMLSLG 85
Cdd:smart00532 1 AQKEISELRKLLNQHDYRYYVLDAPIISDAEYDRLMRELKELEEKHPELKTPDSPTQRVGGKPLEGFNKVRHPVPMLSLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 86 NVFNQEDLFAFARRVEERLPNQkVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLHsdhF 165
Cdd:smart00532 81 NAFDEDELRAFDERIEKALGSP-FAYVVEPKIDGLSVSLLYENGKLVQAATRGDGTVGEDVTQNVKTIRSIPLRLS---G 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 166 EIPRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEPNHGLTTMHDS 245
Cdd:smart00532 157 DVPERLEVRGEVFMPKEDFLALNEELEEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRAFFYGLGTGEELFLPKTQSEA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 246 LQWLTKLGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQAALT 325
Cdd:smart00532 237 LKWLKELGFPVSPHTRLCKNADEVIEYYEEWEEKRAELPYEIDGVVVKVDDLALQRELGFTSKAPRWAIAYKFPAEEAET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 326 TVDQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVWPEFRPVDAEVV 405
Cdd:smart00532 317 KLLDIIVQVGRTGKITPVAELEPVFLAGSTVSRATLHNEDEIEEKDIRIGDTVVVRKAGDVIPKVVGVVKEKRPGDEREI 396
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 491212672 406 HLPENCPVCASPVVMPEGEALARCSGGLyCAAQRIEAIRHFVSRKA 451
Cdd:smart00532 397 EMPTHCPSCGSELVREEGEVDIRCPNPL-CPAQLIERIIHFASRKA 441
|
|
| LIGANc |
cd00114 |
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining ... |
8-320 |
2.31e-161 |
|
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction mechanism. The enzyme reacts with the cofactor to form a phosphoamide-linked AMP with the amino group of a conserved Lysine in the KXDG motif, and subsequently transfers it to the DNA substrate to yield adenylated DNA. This alignment contains members of the NAD+ dependent subfamily only.
Pssm-ID: 238062 [Multi-domain] Cd Length: 307 Bit Score: 465.91 E-value: 2.31e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 8 EQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPMLSLGNV 87
Cdd:cd00114 1 ERIAELRELLNKHDYRYYVLDEPSVSDAEYDRLYRELRALEEEHPELKTPDSPTQRVGGTPLSGFKKVRHPVPMLSLDNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 88 FNQEDLFAFARRVEERLPnQKVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLHsdhfEI 167
Cdd:cd00114 81 FDEEELRAFDERIKRFLG-EEPAYVVEPKIDGLSISLRYENGVLVQAATRGDGTTGEDVTENVRTIRSIPLTLA----GA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 168 PRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEpNHGLTTMHDSLQ 247
Cdd:cd00114 156 PETLEVRGEVFMPKADFEALNKEREERGEKPFANPRNAAAGSLRQLDPKITAKRPLRFFIYGLGEAE-GLGPKTQSEALA 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491212672 248 WLTKLGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPA 320
Cdd:cd00114 235 FLKEWGFPVSPETRLCKNIEEVLAFYDEIEAKRDSLPYEIDGVVVKVDDLALQRELGFTSKAPRWAIAYKFPA 307
|
|
| DNA_ligase_aden |
pfam01653 |
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining ... |
4-321 |
1.09e-155 |
|
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This domain is the catalytic adenylation domain. The NAD+ group is covalently attached to this domain at the lysine in the KXDG motif of this domain. This enzyme- adenylate intermediate is an important feature of the proposed catalytic mechanism.
Pssm-ID: 396292 [Multi-domain] Cd Length: 318 Bit Score: 452.19 E-value: 1.09e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 4 TSVIEQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPMLS 83
Cdd:pfam01653 1 EEAQQQLEELRELIRKYDYEYYVLDNPSVPDAEYDRLYRELKALEEKHPELITPDSPTQRVGAVPLADFNKVRHLTPMLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 84 LGNVFNQEDLFAFARRVEERLPNQ-KVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLHS 162
Cdd:pfam01653 81 LDNAFNLDELQAFIERIRRALGNKeKVEYVVEPKIDGLSISLLYENGLLVRAATRGDGTTGEDVTANVKTIRNIPLKLKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 163 DhfEIPRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEPNH-GLTT 241
Cdd:pfam01653 161 D--NPPERLEVRGEVFMPKEDFEALNEERLEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAYGLGLLEGHElGFDT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 242 MHDSLQWLTKLGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQ 321
Cdd:pfam01653 239 QYQALAFLKSLGFPVSPLLALCDGIEEVLAYYADWEKKRDSLPYEIDGVVVKVDELALQRELGFTAKAPRWAIAYKFPAE 318
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Lig |
COG0272 |
NAD-dependent DNA ligase [Replication, recombination and repair]; |
1-671 |
0e+00 |
|
NAD-dependent DNA ligase [Replication, recombination and repair];
Pssm-ID: 440042 [Multi-domain] Cd Length: 668 Bit Score: 1122.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 1 MATTSVIEQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVP 80
Cdd:COG0272 1 MTPEEAKERIEELREELRRHNYRYYVLDAPEISDAEYDALLRELQALEAEHPELITPDSPTQRVGGAPLEGFAKVRHAVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 81 MLSLGNVFNQEDLFAFARRVEERLPNQKVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVL 160
Cdd:COG0272 81 MLSLDNAFSEEELRDFDRRVRKFLGDEPVEYVCELKIDGLAISLRYENGRLVRAATRGDGTVGEDVTANVRTIRSIPLRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 161 HSDHfeIPRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEpNHGLT 240
Cdd:COG0272 161 KGDD--VPEVLEVRGEVYMPKADFEALNEEREEAGEKPFANPRNAAAGSLRQLDPKITAKRPLDFFAYGLGEVE-GLLPD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 241 TMHDSLQWLTKLGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPA 320
Cdd:COG0272 238 TQSEALELLKEWGFPVNPERRVCKSIEEVLAYIEEWEEKRHSLPYEIDGVVIKVNDLALQERLGFTSRAPRWAIAYKFPA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 321 QAALTTVDQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVWPEFRPV 400
Cdd:COG0272 318 EEATTKLLDIEVQVGRTGALTPVARLEPVFVAGVTVSRATLHNEDEIERKDVRIGDTVVVRKAGDVIPEVVGVVLEKRPG 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 401 DAEVVHLPENCPVCASPVVMPEGEALARCSGGLYCAAQRIEAIRHFVSRKALDIEGLGDRWVESLLHLDLLKDVADIYHL 480
Cdd:COG0272 398 DEKPFVMPTHCPVCGSPLVREEGEAALRCTNGLSCPAQLKERLKHFASRKAMDIEGLGEKLIEQLVDAGLVKDPADLYRL 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 481 heHRETLLGIEKMGEKSVQNLIDAIEASKKTTLARFIYALGIRGVGETTARMLANTFQTLEALKAADVEALKKTPDVGDI 560
Cdd:COG0272 478 --TKEDLLGLERMGEKSAQNLLAAIEKSKKTPLARFLFALGIRHVGETTAKLLARHFGSLDALMAASEEELAAVDGIGPV 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 561 TAEWIADFFLAPHNIEVLDRLIAAGIHWDAPTAPTR--QPLNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTK 638
Cdd:COG0272 556 VAESIVEFFAEPHNRELIERLRAAGVNMEEEEAEAAadSPLAGKTFVLTGTLETMTRDEAKELIEALGGKVSGSVSKKTD 635
|
650 660 670
....*....|....*....|....*....|...
gi 491212672 639 CVVAGEKAGSKLEKAAKLGIAVMNETDFLSLMA 671
Cdd:COG0272 636 YVVAGENAGSKLDKAEELGVPILDEAEFLELLG 668
|
|
| ligA |
PRK07956 |
NAD-dependent DNA ligase LigA; Validated |
2-671 |
0e+00 |
|
NAD-dependent DNA ligase LigA; Validated
Pssm-ID: 236137 [Multi-domain] Cd Length: 665 Bit Score: 1048.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 2 ATTSVIEQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPM 81
Cdd:PRK07956 1 TMEEAKKRIEELREELNHHAYAYYVLDAPSISDAEYDRLYRELVALEAEHPELITPDSPTQRVGGAPLDGFEKVRHLVPM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 82 LSLGNVFNQEDLFAFARRVEERLPNQKVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLH 161
Cdd:PRK07956 81 LSLDNAFSEEELRAFDKRVRKRLPDPPLTYLCELKIDGLAVSLLYENGVLVRAATRGDGTTGEDITANVRTIRSIPLRLH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 162 SDHfeiPRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEPNHGLTT 241
Cdd:PRK07956 161 GNE---PERLEVRGEVFMPKADFEALNEERREEGEKPFANPRNAAAGSLRQLDPKITAKRPLSFFAYGVGEVEGGELPDS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 242 MHDSLQWLTKLGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQ 321
Cdd:PRK07956 238 QSEALEFLKAWGFPVNPYRKLCTSIEEVLAFYEEIEEERHDLPYDIDGVVIKVDDLALQEELGFTAKAPRWAIAYKFPAE 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 322 AALTTVDQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVWPEFRPVD 401
Cdd:PRK07956 318 EATTKLLDIEVQVGRTGAVTPVARLEPVEVAGVTVSRATLHNADEIERKDIRIGDTVVVRRAGDVIPEVVGVVLEKRPGD 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 402 AEVVHLPENCPVCASPVVMPEGEALARCSGGLYCAAQRIEAIRHFVSRKALDIEGLGDRWVESLLHLDLLKDVADIYHLH 481
Cdd:PRK07956 398 EREIVMPTHCPVCGSELVRVEGEAVLRCTNGLSCPAQLKERLIHFVSRNAMDIDGLGEKIIEQLFEKGLIHDPADLFKLT 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 482 EhrETLLGIEKMGEKSVQNLIDAIEASKKTTLARFIYALGIRGVGETTARMLANTFQTLEALKAADVEALKKTPDVGDIT 561
Cdd:PRK07956 478 A--EDLLGLEGFGEKSAQNLLDAIEKSKETSLARFLYALGIRHVGEKAAKALARHFGSLEALRAASEEELAAVEGVGEVV 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 562 AEWIADFFLAPHNIEVLDRLIAAGIHWDAPTAPTrqPLNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTKCVV 641
Cdd:PRK07956 556 AQSIVEFFAVEENRELIDELLEAGVNMEYKGEEV--DLAGKTVVLTGTLEQLSRDEAKEKLEALGAKVSGSVSKKTDLVV 633
|
650 660 670
....*....|....*....|....*....|
gi 491212672 642 AGEKAGSKLEKAAKLGIAVMNETDFLSLMA 671
Cdd:PRK07956 634 AGEAAGSKLAKAQELGIEVLDEEEFLRLLG 663
|
|
| dnlj |
TIGR00575 |
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent ... |
13-666 |
0e+00 |
|
DNA ligase, NAD-dependent; All proteins in this family with known functions are NAD-dependent DNA ligases. Functions of these proteins include DNA repair, DNA replication, and DNA recombination. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). The member of this family from Treponema pallidum differs in having three rather than just one copy of the BRCT (BRCA1 C Terminus) domain (pfam00533) at the C-terminus. It is included in the seed. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273148 [Multi-domain] Cd Length: 652 Bit Score: 863.52 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 13 LIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPMLSLGNVFNQED 92
Cdd:TIGR00575 1 LRKLIRHHDYRYYVLDEPSISDAEYDRLYRELQELEEKHPELITPDSPTQRVGAAPLSRFPKVRHSTPMLSLDNAFDEDE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 93 LFAFARRVEERLpNQKVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLHSDHFeiPRLLE 172
Cdd:TIGR00575 81 LAAFIKRIRRQL-GLKVEYVVEPKIDGLSVSLTYENGVLVRALTRGDGTVGEDVTANVRTIRSIPLRLAGDNP--PERLE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 173 VRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEPnHGLTTMHDSLQWLTKL 252
Cdd:TIGR00575 158 VRGEVFMPKEDFEALNEERREQGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAYGLGEGLE-LPDATQYEALAWLKKW 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 253 GFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQAALTTVDQIDW 332
Cdd:TIGR00575 237 GFPVSPHIRLCDSIEEVLEYYREIEEKRDSLPYEIDGVVVKVDDLALQDELGFTSKAPRWAIAYKFPAEEAQTKLLDVVV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 333 QVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVWPEFRPVDAEVVHLPENCP 412
Cdd:TIGR00575 317 QVGRTGAITPVAKLEPVFVAGTTVSRATLHNEDEIEELDIRIGDTVVVRKAGDVIPKVVRVLLEKRTGSERPIRFPTHCP 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 413 VCASPVVMPEGEALARCSgGLYCAAQRIEAIRHFVSRKALDIEGLGDRWVESLLHLDLLKDVADIYHLHEhrETLLGIEK 492
Cdd:TIGR00575 397 SCGSPLVKIEEEAVIRCP-NLNCPAQRVERIKHFASRNAMDIEGLGDKVIEQLFEKKLVRSVADLYALKK--EDLLELEG 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 493 MGEKSVQNLIDAIEASKKTTLARFIYALGIRGVGETTARMLANTFQTLEALKAADVEALKKTPDVGDITAEWIADFFLAP 572
Cdd:TIGR00575 474 FGEKSAQNLLNAIEKSKEKPLARLLFALGIRHVGEVTAKNLAKHFGTLDKLKAASLEELLSVEGVGPKVAESIVNFFHDP 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 573 HNIEVLDRLIAAGIHWDA-----PTAPTRQPLNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTKCVVAGEKAG 647
Cdd:TIGR00575 554 NNRQLIKKLEELGVEMESlpekvNAELAGSPLAGKTFVLTGTLSQMSRDEAKELLENLGGKVASSVSKKTDYVIAGEKAG 633
|
650
....*....|....*....
gi 491212672 648 SKLEKAAKLGIAVMNETDF 666
Cdd:TIGR00575 634 SKLAKAQELGIPIINEEEL 652
|
|
| LIGANc |
smart00532 |
Ligase N family; |
6-451 |
0e+00 |
|
Ligase N family;
Pssm-ID: 214709 [Multi-domain] Cd Length: 441 Bit Score: 631.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 6 VIEQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPMLSLG 85
Cdd:smart00532 1 AQKEISELRKLLNQHDYRYYVLDAPIISDAEYDRLMRELKELEEKHPELKTPDSPTQRVGGKPLEGFNKVRHPVPMLSLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 86 NVFNQEDLFAFARRVEERLPNQkVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLHsdhF 165
Cdd:smart00532 81 NAFDEDELRAFDERIEKALGSP-FAYVVEPKIDGLSVSLLYENGKLVQAATRGDGTVGEDVTQNVKTIRSIPLRLS---G 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 166 EIPRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEPNHGLTTMHDS 245
Cdd:smart00532 157 DVPERLEVRGEVFMPKEDFLALNEELEEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRAFFYGLGTGEELFLPKTQSEA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 246 LQWLTKLGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQAALT 325
Cdd:smart00532 237 LKWLKELGFPVSPHTRLCKNADEVIEYYEEWEEKRAELPYEIDGVVVKVDDLALQRELGFTSKAPRWAIAYKFPAEEAET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 326 TVDQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVWPEFRPVDAEVV 405
Cdd:smart00532 317 KLLDIIVQVGRTGKITPVAELEPVFLAGSTVSRATLHNEDEIEEKDIRIGDTVVVRKAGDVIPKVVGVVKEKRPGDEREI 396
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 491212672 406 HLPENCPVCASPVVMPEGEALARCSGGLyCAAQRIEAIRHFVSRKA 451
Cdd:smart00532 397 EMPTHCPSCGSELVREEGEVDIRCPNPL-CPAQLIERIIHFASRKA 441
|
|
| ligA |
PRK14351 |
NAD-dependent DNA ligase LigA; Provisional |
8-677 |
0e+00 |
|
NAD-dependent DNA ligase LigA; Provisional
Pssm-ID: 184640 [Multi-domain] Cd Length: 689 Bit Score: 623.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 8 EQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYpDLVQSDSPTTKVGGQALSKFQSVTHVVPMLSLGNV 87
Cdd:PRK14351 34 EQAEQLREAIREHDHRYYVEADPVIADRAYDALFARLQALEDAF-DLDTENSPTRRVGGEPLDELETVEHVAPMLSIDQS 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 88 FNQEDLFAFARRVEERLpnQKVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLHSDHfei 167
Cdd:PRK14351 113 GEADDVREFDERVRREV--GAVEYVCEPKFDGLSVEVVYEDGEYQRAATRGDGREGDDVTANVRTIRSVPQKLRGDY--- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 168 PRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGI---AQCEPNHGltTMHD 244
Cdd:PRK14351 188 PDFLAVRGEVYMPKDAFQAYNRERIERGEEPFANPRNAAAGTLRQLDPSVVAERPLDIFFFDVldaSELFDSHW--EELE 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 245 SLQ-WltklGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQAA 323
Cdd:PRK14351 266 RFPeW----GLRVTDRTERVDDIDDAIAYRDRLLAARDDLNYEIDGVVIKVDDRDAREELGATARAPRWAFAYKFPARAE 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 324 LTTVDQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVwpefrpVDAE 403
Cdd:PRK14351 342 ETTIRDIVVQVGRTGRLTPVALLDPVDVGGVTVSRASLHNPAEIEELGVNVGDRVRVKRAGDVIPYVEEV------VEKD 415
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 404 ---VVHLPENCPVCASPVvmPEGEALARCSGGLYCAAQRIEAIRHFVSRKALDIEGLGDRWVESLLHLDLLKDVADIYHL 480
Cdd:PRK14351 416 segTFEFPDTCPVCDSAV--ERDGPLAFCTGGLACPAQLERSIEHYASRDALDIEGLGEERVQQLVDAGLVESLADLYDL 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 481 heHRETLLGIEKMGEKSVQNLIDAIEASKKTTLARFIYALGIRGVGETTARMLANTFQTLEALKAADVEALKKTPDVGDI 560
Cdd:PRK14351 494 --TVADLAELEGWGETSAENLLAELEASREPPLADFLVALGIPEVGPTTARNLAREFGTFEAIMDADEEALRAVDDVGPT 571
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 561 TAEWIADFFLAPHNIEVLDRLIAAGIHWDAPTAPTRQPLNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTKCV 640
Cdd:PRK14351 572 VAEEIREFFDSERNRAVIDDLLDHGVDPQPAESEGGDALDGLTFVFTGSLSGYTRSEAQELVEAHGGNATGSVSGNTDYL 651
|
650 660 670
....*....|....*....|....*....|....*...
gi 491212672 641 VAGEKAG-SKLEKAAKLGIAVMNETDFLSLMASYGQTL 677
Cdd:PRK14351 652 VVGENPGqSKRDDAEANDVPTLDEEEFEELLAERGVAL 689
|
|
| LIGANc |
cd00114 |
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining ... |
8-320 |
2.31e-161 |
|
NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction mechanism. The enzyme reacts with the cofactor to form a phosphoamide-linked AMP with the amino group of a conserved Lysine in the KXDG motif, and subsequently transfers it to the DNA substrate to yield adenylated DNA. This alignment contains members of the NAD+ dependent subfamily only.
Pssm-ID: 238062 [Multi-domain] Cd Length: 307 Bit Score: 465.91 E-value: 2.31e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 8 EQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPMLSLGNV 87
Cdd:cd00114 1 ERIAELRELLNKHDYRYYVLDEPSVSDAEYDRLYRELRALEEEHPELKTPDSPTQRVGGTPLSGFKKVRHPVPMLSLDNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 88 FNQEDLFAFARRVEERLPnQKVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLHsdhfEI 167
Cdd:cd00114 81 FDEEELRAFDERIKRFLG-EEPAYVVEPKIDGLSISLRYENGVLVQAATRGDGTTGEDVTENVRTIRSIPLTLA----GA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 168 PRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEpNHGLTTMHDSLQ 247
Cdd:cd00114 156 PETLEVRGEVFMPKADFEALNKEREERGEKPFANPRNAAAGSLRQLDPKITAKRPLRFFIYGLGEAE-GLGPKTQSEALA 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491212672 248 WLTKLGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPA 320
Cdd:cd00114 235 FLKEWGFPVSPETRLCKNIEEVLAFYDEIEAKRDSLPYEIDGVVVKVDDLALQRELGFTSKAPRWAIAYKFPA 307
|
|
| DNA_ligase_aden |
pfam01653 |
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining ... |
4-321 |
1.09e-155 |
|
NAD-dependent DNA ligase adenylation domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This domain is the catalytic adenylation domain. The NAD+ group is covalently attached to this domain at the lysine in the KXDG motif of this domain. This enzyme- adenylate intermediate is an important feature of the proposed catalytic mechanism.
Pssm-ID: 396292 [Multi-domain] Cd Length: 318 Bit Score: 452.19 E-value: 1.09e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 4 TSVIEQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPMLS 83
Cdd:pfam01653 1 EEAQQQLEELRELIRKYDYEYYVLDNPSVPDAEYDRLYRELKALEEKHPELITPDSPTQRVGAVPLADFNKVRHLTPMLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 84 LGNVFNQEDLFAFARRVEERLPNQ-KVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLHS 162
Cdd:pfam01653 81 LDNAFNLDELQAFIERIRRALGNKeKVEYVVEPKIDGLSISLLYENGLLVRAATRGDGTTGEDVTANVKTIRNIPLKLKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 163 DhfEIPRLLEVRGEVLMPKSGFEKLNAEQEAKGDKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEPNH-GLTT 241
Cdd:pfam01653 161 D--NPPERLEVRGEVFMPKEDFEALNEERLEEGEKPFANPRNAAAGSLRQLDPRITAKRKLRFFAYGLGLLEGHElGFDT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 242 MHDSLQWLTKLGFEIAERQYLCNSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQ 321
Cdd:pfam01653 239 QYQALAFLKSLGFPVSPLLALCDGIEEVLAYYADWEKKRDSLPYEIDGVVVKVDELALQRELGFTAKAPRWAIAYKFPAE 318
|
|
| ligA |
PRK14350 |
NAD-dependent DNA ligase LigA; Provisional |
8-670 |
1.07e-112 |
|
NAD-dependent DNA ligase LigA; Provisional
Pssm-ID: 172826 [Multi-domain] Cd Length: 669 Bit Score: 353.75 E-value: 1.07e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 8 EQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQALSKFQSVTHVVPMLSLGNV 87
Cdd:PRK14350 7 DEILDLKKLIRKWDKEYYVDSSPSVEDFTYDKALLRLQELESKYPEYKTLDSPTLKFGSDLLNDFKEVEHSFPILSLDKV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 88 FNQEDLFAFARRV--EERLPNQKVQYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLhSDHF 165
Cdd:PRK14350 87 YDLKLLKLWIEKMdlENSNLGFDFGISVEPKIDGCSIVLYYKDGILEKALTRGDGRFGNDVTENVRTIRNVPLFI-DEKV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 166 EiprlLEVRGEVLMPKSGFEKLNAEQEakgdKTFANPRNAAAGSLRQLDPNIAAARPLAFYAYGIAQCEpnHGLTTMHDS 245
Cdd:PRK14350 166 E----LVLRGEIYITKENFLKINKTLE----KPYTNARNLASGILRRIDSREVANFPLDIFVYDILYSS--LELKTNHDA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 246 LQWLTKLGFEIAER-QYLC--NSIQEVQQRYEQIQQERSDLQVEIDGMVVKVDDLKQQQQLGFLSREPRWATAYKFPAQA 322
Cdd:PRK14350 236 FDKLKKFGFKVNPFcRFFDgkNSIEEILNYVKDIEKKRNSFEYEIDGVVLKVSDFALREILGYTSHHPKWSMAYKFESLS 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 323 ALTTVDQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVWPEFrpvDA 402
Cdd:PRK14350 316 GFSKVNDIVVQVGRSGKITPVANIEKVFVAGAFITNASLHNQDYIDSIGLNVGDVVKISRRGDVIPAVELVIEKL---SV 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 403 EVVHLPENCPVCASpVVMPEGEALArCSGGlYCAAQRIEAIRHFVSRKALDIEGLGDRWVESLLHLDLLKDVADIYHLHE 482
Cdd:PRK14350 393 GFFKIPDNCPSCKT-ALIKEGAHLF-CVNN-HCPSVIVERIKYFCSKKCMNIVGLSDKTIEFLFEKKFISSEIDLYTFNF 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 483 HRetLLGIEKMGEKSVQNLIDAIEASKKTTLARFIYALGIRGVGETTARML----ANTFQTLEAL---KAADVEALKKTP 555
Cdd:PRK14350 470 DR--LINLKGFKDKRINNLKRSIEASKKRPFSKLLLSMGIKDLGENTILLLinnnLNSFDKISTLcqdREFALSKLLKIK 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 556 DVGDITAEWIADFF---LAPHNIEVLDRLIAAGIHWDAPTAPTRQPLNGESWVLTGTLEQMTRDQATQMLQALGARVSGS 632
Cdd:PRK14350 548 GIGEKIALNIIEAFndkIILDKFNFFKNLGFKMEEDSINIDVENSFLFGKKFCITGSFNGYSRSVLIDKLTKKGAIFNTC 627
|
650 660 670
....*....|....*....|....*....|....*...
gi 491212672 633 VSSKTKCVVAGEKAGSKLEKAAKLGIAVMNETDFLSLM 670
Cdd:PRK14350 628 VTKYLDFLLVGEKAGLKLKKANNLGIKIMSLFDIKSYV 665
|
|
| ligB |
PRK08097 |
NAD-dependent DNA ligase LigB; |
8-587 |
2.05e-39 |
|
NAD-dependent DNA ligase LigB;
Pssm-ID: 236150 [Multi-domain] Cd Length: 562 Bit Score: 153.15 E-value: 2.05e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 8 EQMRQLIQLIAKHNHAYYVMDQPTISDSEYDHLFHQLKALEEQYPDLVQSDSPTTKVGGQalskfqsVTHVVPMLSLGNV 87
Cdd:PRK08097 32 EEIAALQQQLAQWDDAYWRQGKSEVDDEVYDQLRARLTQWQRCFGGPEPRDVPLPPLNGK-------VLHPVAHTGVKKL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 88 FNQEDLfafARRVEERLPnqkvqYEVELKLDGLAISLWYENGVLIRGVTRGDGETGEDITQNVKTIRNLPKVLHsdhfEI 167
Cdd:PRK08097 105 ADKQAL---ARWMAGRSD-----LWVQPKVDGVAVTLVYRDGKLVQAISRGNGLKGEDWTAKARLIPAIPQQLP----GA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 168 PRLLEVRGEVlmpksgFEKLNAEQEAK--GdktfANPRNAAAGSLRQLDPNIAAARplafyaYGIAQCEPNHGLTTMHDS 245
Cdd:PRK08097 173 LANLVLQGEL------FLRREGHIQQQmgG----INARAKVAGLMMRKDPSPTLNQ------IGVFVWAWPDGPASMPER 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 246 LQWLTKLGFEIAERqYL--CNSIQEVQQRYEQiqQERSDLQVEIDGMVVKVDDLKQQQQlgFLSREPRWATAYKFPAQAA 323
Cdd:PRK08097 237 LAQLATAGFPLTQR-YThpVKNAEEVARWRER--WYRAPLPFVTDGVVVRQAKEPPGRY--WQPGQGEWAVAWKYPPVQQ 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 324 LTTVDQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVtlhNIGEIHR---LDVRVGDTVSVYRTGDVIPKVEKV-WpefRP 399
Cdd:PRK08097 312 VAEVRAVQFAVGRTGKITVVLELEPVMLDDKRVSRV---NIGSVRRwqqWDIAPGDQVLVSLAGQGIPRLDKVvW---RG 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 400 VDAEVVHLPEN-------C----PVCaspvvmpEGEALARCS--GGlycaaqrieairhfvsRKALDIEGLGDRWVESLL 466
Cdd:PRK08097 386 AERTKPTPPDAdrfhslsCfrasPGC-------QEQFLARLVwlSG----------------KQGLGLDGIGEGTWRALH 442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 467 HLDLLKDVADIYHLHEhrETLLGIEKMGEKSVQNLIDAIEASKKTTLARFIYALGIRGVGETTARMLANTFQTLEALKAA 546
Cdd:PRK08097 443 QTGLFEHLFSWLALTP--EQLANTPGIGKARAEQLWHQFNLARQQPFSRWLKALGIPLPQAALNALDDRSWQQLLSRSEQ 520
|
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 491212672 547 DVEALkktPDVGDITAEWIADFFLAPHNIEVLDRLIAAGIH 587
Cdd:PRK08097 521 QWQQL---PGIGEGRARQLIAFLQHPEVKALADWLAAQGIT 558
|
|
| DNA_ligase_OB |
pfam03120 |
NAD-dependent DNA ligase OB-fold domain; DNA ligases catalyze the crucial step of joining the ... |
325-402 |
8.71e-38 |
|
NAD-dependent DNA ligase OB-fold domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This family is a small domain found after the adenylation domain pfam01653 in NAD dependent ligases. OB-fold domains generally are involved in nucleic acid binding.
Pssm-ID: 460813 [Multi-domain] Cd Length: 79 Bit Score: 134.80 E-value: 8.71e-38
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491212672 325 TTVDQIDWQVGRTGTLTPVARLNPVFVGGVTVSNVTLHNIGEIHRLDVRVGDTVSVYRTGDVIPKVEKVWPEFRPVDA 402
Cdd:pfam03120 2 TKLLDIEFQVGRTGAITPVAVLEPVELAGTTVSRATLHNEDEIKRKDIRIGDTVIVRKAGDVIPEVVGVVLEKRPGDE 79
|
|
| BRCT_DNA_ligase_like |
cd17748 |
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also ... |
599-669 |
4.67e-26 |
|
BRCT domain of bacterial NAD-dependent DNA ligase (LigA) and similar proteins; LigA, also called NAD(+)-dependent polydeoxyribonucleotide synthase, catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.
Pssm-ID: 349379 [Multi-domain] Cd Length: 76 Bit Score: 101.79 E-value: 4.67e-26
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491212672 599 LNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTKCVVAGEKAGSKLE-----KAAKLGIAVMNETDFLSL 669
Cdd:cd17748 1 LAGKTFVFTGTLSSMSRDEAEELIEALGGKVQSSVSKKTDYLVVGDNAGSKLKkgeelKAKGLGIKIISEEEFLDL 76
|
|
| HHH_2 |
pfam12826 |
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is ... |
515-578 |
5.49e-21 |
|
Helix-hairpin-helix motif; The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain.
Pssm-ID: 432812 [Multi-domain] Cd Length: 64 Bit Score: 86.81 E-value: 5.49e-21
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491212672 515 RFIYALGIRGVGETTARMLANTFQTLEALKAADVEALKKTPDVGDITAEWIADFFLAPHNIEVL 578
Cdd:pfam12826 1 RLLFALGIRHVGETTAKLLARRFGSLDALAEASLEELLEVDDIGPEIAQSIVEFFADPANRELI 64
|
|
| BRCT_RFC1 |
cd17752 |
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed ... |
599-669 |
1.65e-18 |
|
BRCT domain of replication factor C subunit 1 (RFC1) and similar proteins; RFC1, also termed activator 1 140 kDa subunit, or A1 140 kDa subunit, or activator 1 large subunit, or activator 1 subunit 1, or replication factor C 140 kDa subunit, or RF-C 140 kDa subunit, or RFC140, is the large subunit of replication factor C (RFC), which is a heteropentameric protein essential for DNA replication and repair. RFC1 can bind single- or double-stranded DNA. It could play a role in DNA transcription regulation as well as DNA replication and/or repair. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is not conserved in this family.
Pssm-ID: 349383 [Multi-domain] Cd Length: 79 Bit Score: 80.33 E-value: 1.65e-18
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491212672 599 LNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTKCVVAGEKAG-SKLEKAAKLGIAVMNETDFLSL 669
Cdd:cd17752 6 LEGLTFVITGVLESLEREEAEDLIKRYGGKVTGSVSKKTSYLVVGRDAGpSKLEKAKELGTKIIDEDGLFDL 77
|
|
| BRCT |
pfam00533 |
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
594-670 |
8.17e-09 |
|
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 52.68 E-value: 8.17e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491212672 594 PTRQPLNGESWVLTGtLEQMTRDQATQMLQALGARVSGSVSSKTKCVVAGEKAgSKLEKAAKLGIAVMNETDFLSLM 670
Cdd:pfam00533 1 PKEKLFSGKTFVITG-LDGLERDELKELIEKLGGKVTDSLSKKTTHVIVEART-KKYLKAKELGIPIVTEEWLLDCI 75
|
|
| BRCT |
smart00292 |
breast cancer carboxy-terminal domain; |
598-670 |
5.85e-08 |
|
breast cancer carboxy-terminal domain;
Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 50.45 E-value: 5.85e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491212672 598 PLNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTK-CVVAGEKAGSKLE--KAAKLGIAVMNETDFLSLM 670
Cdd:smart00292 3 LFKGKTFYITGSFDKEERDELKELIEALGGKVTSSLSSKTTtHVIVGSPEGGKLEllKAIALGIPIVKEEWLLDCL 78
|
|
| PRK06195 |
PRK06195 |
DNA polymerase III subunit epsilon; Validated |
598-669 |
1.01e-07 |
|
DNA polymerase III subunit epsilon; Validated
Pssm-ID: 235735 [Multi-domain] Cd Length: 309 Bit Score: 54.40 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 598 PLNGESWVLTGTLEQMTRDQATQMLQALGARVSGSVSSKTKCVVAG---------EKAGSKLEKAAKL-----GIAVMNE 663
Cdd:PRK06195 220 AFKEEVVVFTGGLASMTRDEAMILVRRLGGTVGSSVTKKTTYLVTNtkdiedlnrEEMSNKLKKAIDLkkkgqNIKFLNE 299
|
....*.
gi 491212672 664 TDFLSL 669
Cdd:PRK06195 300 EEFLQK 305
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
516-563 |
5.84e-07 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 46.71 E-value: 5.84e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 491212672 516 FIYALGIRGVGETTARMLANT-FQTLEALKAADVEALKKTPDVGDITAE 563
Cdd:pfam14520 1 FEELLSISGIGPKTALALLSAgIGTVEDLAEADVDELAEIPGIGEKTAQ 49
|
|
| BRCT_PARP1 |
cd17747 |
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2. ... |
605-667 |
1.44e-06 |
|
BRCT domain of poly [ADP-ribose] polymerase 1 (PARP-1) and similar proteins; PARP-1 (EC 2.4.2.30), also termed ADP-ribosyltransferase diphtheria toxin-like 1 (ARTD1), or NAD(+) ADP-ribosyltransferase 1 (ADPRT 1), or poly[ADP-ribose] synthase 1, is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism.
Pssm-ID: 349378 [Multi-domain] Cd Length: 76 Bit Score: 46.37 E-value: 1.44e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491212672 605 VLTGTLEqMTRDQATQMLQALGARVSGSVSSKTKCVVA----GEKAGSKLEKAAKLGIAVMNEtDFL 667
Cdd:cd17747 7 ALIGKLS-KSKDELKKLIEKLGGKVASKVTKKVTLCIStkaeVEKMSKKMKEAKEAGVPVVSE-DFL 71
|
|
| DNA_ligase_ZBD |
pfam03119 |
NAD-dependent DNA ligase C4 zinc finger domain; DNA ligases catalyze the crucial step of ... |
410-435 |
1.54e-06 |
|
NAD-dependent DNA ligase C4 zinc finger domain; DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor. This family is a small zinc binding motif that is presumably DNA binding. IT is found only in NAD dependent DNA ligases.
Pssm-ID: 460812 [Multi-domain] Cd Length: 26 Bit Score: 44.73 E-value: 1.54e-06
10 20
....*....|....*....|....*.
gi 491212672 410 NCPVCASPVVMPEGEALARCSgGLYC 435
Cdd:pfam03119 1 HCPVCGSPLVREEGEAALRCT-NLSC 25
|
|
| MUS81 |
COG1948 |
ERCC4-type crossover junction endonuclease [Replication, recombination and repair]; |
515-565 |
3.07e-04 |
|
ERCC4-type crossover junction endonuclease [Replication, recombination and repair];
Pssm-ID: 441551 [Multi-domain] Cd Length: 214 Bit Score: 42.47 E-value: 3.07e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 491212672 515 RFIYAlGIRGVGETTARMLANTFQTLEALKAADVEALKKTPDVGDITAEWI 565
Cdd:COG1948 154 LYVVE-SLPGIGPKLARRLLEHFGSVEAVFNASEEELMKVEGIGEKTAERI 203
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
509-568 |
1.64e-03 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 41.78 E-value: 1.64e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491212672 509 KKTTLA---RFIYAlGIRGVGETTARMLANTFQTLEALKAADVEALKKTPDVGDITAEWIADF 568
Cdd:PRK13766 705 KAMTLKeqqEYIVE-SLPDVGPVLARNLLEHFGSVEAVMTASEEELMEVEGIGEKTAKRIREV 766
|
|
| BRCT |
cd00027 |
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ... |
605-663 |
2.78e-03 |
|
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.
Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 36.96 E-value: 2.78e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 491212672 605 VLTGtLEQMTRDQATQMLQALGARVSGSVSSKTKCVVAGEKAGSK-LEKAAKLGIAVMNE 663
Cdd:cd00027 4 CFSG-LDDEEREELKKLIEALGGKVSESLSSKVTHLIAKSPSGEKyYLAALAWGIPIVSP 62
|
|
| |
