|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
3-498 |
1.25e-171 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 495.10 E-value: 1.25e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 3 LHQLYLDLLIGGLVLLASIVGTRVATRIGFPSLLFFLLVGVVLGEDGLG-LEFDNVELARNVCTAALAVILVEGGLTTRF 81
Cdd:PRK05326 1 MDTINSLLLIGALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGgIQFDNYPLAYLVGNLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 82 ADIRKVLAPAGALATVGVVVSTVVTAFGAHVLLRMDWQLALLLGAIVSSTDAAAVFSVLRVLP--LPRRLAGLLEAESGF 159
Cdd:PRK05326 81 SSFRPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAVFSLLRGKGlnLKERVASTLEIESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 160 NDAPAVILVLMFSIVPFVFEPKST---AVQIVYELLAGSAIGLLCGFLGAMALRRVALPASGLYPIATFGIGLVAFAASG 236
Cdd:PRK05326 161 NDPMAVFLTITLIELITGGETGLSwgfLLLFLQQFGLGALIGLLGGWLLVQLLNRIALPAEGLYPILVLAGALLIFALTA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 237 TVHASGFIAAYLAAVVLANSGLPHRSATRSFAEGLGWLAQIGLFVLLGLLVNPSELMDDLLPAILVGLVLLLVARPLSVV 316
Cdd:PRK05326 241 ALGGSGFLAVYLAGLVLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLLVTPSRLLDIALPALLLALFLILVARPLAVF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 317 VSLIGFGVPWREQAFLSWAGLRGAVPVVLATFPIVAGVPDSYRLLNIVFVLVVVFTLVQGPSLRPVAHLLGLITREATRE 396
Cdd:PRK05326 321 LSLLPFRFNLREKLFISWVGLRGAVPIVLATFPMMAGLPNAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGVVVPPEARP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 397 I-QVEAAPLDVLDAELLTMKVQPASRLRNVTILELRLPDPAVVTLIIRQGNTFVPLPDTRIEPGDELMIVTTSKTRALTE 475
Cdd:PRK05326 401 VsRVELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALE 480
|
490 500
....*....|....*....|...
gi 491224303 476 SRLRAVSRRGKLAYWFDEYGDVG 498
Cdd:PRK05326 481 RLFSQSPPGKLDQRFFGDFILEG 503
|
|
| NhaP2 |
COG3263 |
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ... |
3-498 |
1.56e-165 |
|
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 442494 [Multi-domain] Cd Length: 502 Bit Score: 477.29 E-value: 1.56e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 3 LHQLYLDLLIGGLVLLASIVGTRVATRIGFPSLLFFLLVGVVLGEDGLG-LEFDNVELARNVCTAALAVILVEGGLTTRF 81
Cdd:COG3263 1 MDTLNLILLIGALLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGgIQFDDAELAQLIGSLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 82 ADIRKVLAPAGALATVGVVVSTVVTAFGAHVLLRMDWQLALLLGAIVSSTDAAAVFSVLRV--LPLPRRLAGLLEAESGF 159
Cdd:COG3263 81 SSFRPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAVFSILRSkgLNLKERLASTLELESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 160 NDAPAVILVLMFS--IVPFVFEPKSTAVQIVYELLAGSAIGLLCGFLGAMALRRVALPASGLYPIATFGIGLVAFAASGT 237
Cdd:COG3263 161 NDPMAVFLTIALIelITGGGASGWSLLLLFVLQMGLGALVGLAGGWLGVWLLNRIRLPAEGLYPVLVLALALLAFGATAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 238 VHASGFIAAYLAAVVLANSGLPHRSATRSFAEGLGWLAQIGLFVLLGLLVNPSELMDDLLPAILVGLVLLLVARPLSVVV 317
Cdd:COG3263 241 LGGSGFLAVYLAGLVLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLGLLVFPSRLLPVALPALLIALFLIFVARPLAVFL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 318 SLIGFGVPWREQAFLSWAGLRGAVPVVLATFPIVAGVPDSYRLLNIVFVLVVVFTLVQGPSLRPVAHLLGLITREATREI 397
Cdd:COG3263 321 SLLPFRFSWREKLFISWVGLRGAVPIVLATFPLLAGLPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKPL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 398 Q-VEAAPLDVLDAELLTMKVQPASRLRNVTILELRLPDPAVVTLIIRQGNTFVPLPDTRIEPGDELMIVTTSKTRALTES 476
Cdd:COG3263 401 TrVELELLEELDAELVEYRVPPGSPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALER 480
|
490 500
....*....|....*....|..
gi 491224303 477 RLRAVSRRGKLAYWFDEYGDVG 498
Cdd:COG3263 481 LFAAVSRAGTLAEWFGDRVRLG 502
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
15-383 |
4.21e-22 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 97.71 E-value: 4.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 15 LVLLASIVGTRVATRIGFPSLLFFLLVGVVLGEDGLGLEFDNVELARNVCTAALAVILVEGGLTTRFADIRKVLAPAGAL 94
Cdd:pfam00999 3 LLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 95 ATVGVVVSTVVTAFGAH-VLLRMDWQLALLLGAIVSSTDAAAVFSVLRVL-PLPRRLAGLLEAESGFNDAPAVILVLMF- 171
Cdd:pfam00999 83 ALLGVLIPFVLIGLLLYlLGLGIPLLEALLFGAILSATSPVVVLAILKELgRVPERLGTLLLGESVLNDGVAVVLLAVLl 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 172 ---SIVPFVFEPKSTAVQIVYELLAGSAIGLLCGFLGAMALRRVALPASgLYPIATFGIGLVAFAASGTVHASGFIAAYL 248
Cdd:pfam00999 163 alaQGVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRE-LEVLLVLLLALLAALLAEALGVSGILGAFL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 249 AAVVLANSGLPHRSATRSFAEGlGWLAQIGLFVLLGLLVNPSELMDDLLPAILVGLVLLLVARPLSVVVSLIGFGVPWRE 328
Cdd:pfam00999 242 AGLVLSEYPFANKLSEKLEPFG-YGLFNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLGLSLRE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 491224303 329 QAFLSWAGL-RGAVPVVLATFPIVAGVPDSyRLLNIVFVLVVVFTLVQGPSLRPVA 383
Cdd:pfam00999 321 ALIIGFGGLqRGAVSLALAAIGPLLGIIAR-ELYPLLIVVVLFTVLVQGITLKPLL 375
|
|
| a_cpa1 |
TIGR00831 |
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ... |
10-379 |
1.88e-13 |
|
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129911 [Multi-domain] Cd Length: 525 Bit Score: 72.61 E-value: 1.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 10 LLIGGLVLLASIVGTRVAT-RIGFPSLLffLLVGVVLGEDGLGLEfdnVELARNVCTAA-LAVILVEGGLTTRFADIRKV 87
Cdd:TIGR00831 1 VEIIELVMLATAVAVTVKFiRLPYPIAL--ILAGLLLGLAGLLPE---VPLDREIVLFLfLPPLLFEAAMNTDLRELREN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 88 LAPAGALATVGVVVSTVVTAFGAHVLLRMDWQLALLLGAIVSSTDAAAVFSVLRVLPLPRRLAGLLEAESGFNDAPAVIL 167
Cdd:TIGR00831 76 FRPIALIAFLLVVVTTVVVGFSLNWILGIPLALALILGAVLSPTDAVAVLGTFKSIRAPKKLSILLEGESLLNDGAALVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 168 ---VLMFSIVPFVFEPKSTAVQIVYELLAGSAIGLLCGFLGAMALRRvALPASGLYPIATFGIGLVAFAASGTVHASGFI 244
Cdd:TIGR00831 156 faiAVAVALGKGVFDPLNAALDFAVVCVGGIAAGLAVGYLAYRLLRA-KIDDPLVEIALTILAPFAGFLLAERFHFSGVI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 245 AAYLAAVVLANSGLPHRSATRSFAEGLGWLAQIG----LFVLLGLLVNPSELMDDLLPAILVGLVLLLVARPLSVVV--- 317
Cdd:TIGR00831 235 AVVAAGLILTNYGRDFSMSPTTRLIALDFWSVIVflvnGIIFILIGVQTPGTIFSAWKEILVAPAAVILALFTNAFViyp 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 318 --SLIGF-----------------GVPWREQAFLSWAGLRGAVPVVLA-----TFPIVAGVPDSYRLLNIVFVLVVVFTL 373
Cdd:TIGR00831 315 vmTYVRFlwtmkpfsnrflkkkpmEFGTRWKHVVSWAGLRGAIPLALAlsfpnQLLSGMAFPARYELVFLAAGVILFSLL 394
|
....*.
gi 491224303 374 VQGPSL 379
Cdd:TIGR00831 395 VQGISL 400
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05326 |
PRK05326 |
potassium/proton antiporter; |
3-498 |
1.25e-171 |
|
potassium/proton antiporter;
Pssm-ID: 235410 [Multi-domain] Cd Length: 562 Bit Score: 495.10 E-value: 1.25e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 3 LHQLYLDLLIGGLVLLASIVGTRVATRIGFPSLLFFLLVGVVLGEDGLG-LEFDNVELARNVCTAALAVILVEGGLTTRF 81
Cdd:PRK05326 1 MDTINSLLLIGALLLLLSILASRLSSRLGIPSLLLFLAIGMLAGEDGLGgIQFDNYPLAYLVGNLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 82 ADIRKVLAPAGALATVGVVVSTVVTAFGAHVLLRMDWQLALLLGAIVSSTDAAAVFSVLRVLP--LPRRLAGLLEAESGF 159
Cdd:PRK05326 81 SSFRPALGPALSLATLGVLITAGLTGLFAHWLLGLDWLEGLLLGAIVGSTDAAAVFSLLRGKGlnLKERVASTLEIESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 160 NDAPAVILVLMFSIVPFVFEPKST---AVQIVYELLAGSAIGLLCGFLGAMALRRVALPASGLYPIATFGIGLVAFAASG 236
Cdd:PRK05326 161 NDPMAVFLTITLIELITGGETGLSwgfLLLFLQQFGLGALIGLLGGWLLVQLLNRIALPAEGLYPILVLAGALLIFALTA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 237 TVHASGFIAAYLAAVVLANSGLPHRSATRSFAEGLGWLAQIGLFVLLGLLVNPSELMDDLLPAILVGLVLLLVARPLSVV 316
Cdd:PRK05326 241 ALGGSGFLAVYLAGLVLGNRPIRHRHSILRFFDGLAWLAQIGMFLVLGLLVTPSRLLDIALPALLLALFLILVARPLAVF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 317 VSLIGFGVPWREQAFLSWAGLRGAVPVVLATFPIVAGVPDSYRLLNIVFVLVVVFTLVQGPSLRPVAHLLGLITREATRE 396
Cdd:PRK05326 321 LSLLPFRFNLREKLFISWVGLRGAVPIVLATFPMMAGLPNAQLIFNVVFFVVLVSLLLQGTTLPWAARKLGVVVPPEARP 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 397 I-QVEAAPLDVLDAELLTMKVQPASRLRNVTILELRLPDPAVVTLIIRQGNTFVPLPDTRIEPGDELMIVTTSKTRALTE 475
Cdd:PRK05326 401 VsRVELDPLEESDAELLEYRVPAGSWLVGKALRDLRLPRGALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALE 480
|
490 500
....*....|....*....|...
gi 491224303 476 SRLRAVSRRGKLAYWFDEYGDVG 498
Cdd:PRK05326 481 RLFSQSPPGKLDQRFFGDFILEG 503
|
|
| NhaP2 |
COG3263 |
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ... |
3-498 |
1.56e-165 |
|
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];
Pssm-ID: 442494 [Multi-domain] Cd Length: 502 Bit Score: 477.29 E-value: 1.56e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 3 LHQLYLDLLIGGLVLLASIVGTRVATRIGFPSLLFFLLVGVVLGEDGLG-LEFDNVELARNVCTAALAVILVEGGLTTRF 81
Cdd:COG3263 1 MDTLNLILLIGALLLLLSILASKLSSRLGVPLLLLFLGIGMLAGEDGLGgIQFDDAELAQLIGSLALAVILFDGGLRTRW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 82 ADIRKVLAPAGALATVGVVVSTVVTAFGAHVLLRMDWQLALLLGAIVSSTDAAAVFSVLRV--LPLPRRLAGLLEAESGF 159
Cdd:COG3263 81 SSFRPVLAPALSLATLGVLLTAGLTGVFAHWLLGLSWLEGLLLGAIVSSTDAAAVFSILRSkgLNLKERLASTLELESGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 160 NDAPAVILVLMFS--IVPFVFEPKSTAVQIVYELLAGSAIGLLCGFLGAMALRRVALPASGLYPIATFGIGLVAFAASGT 237
Cdd:COG3263 161 NDPMAVFLTIALIelITGGGASGWSLLLLFVLQMGLGALVGLAGGWLGVWLLNRIRLPAEGLYPVLVLALALLAFGATAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 238 VHASGFIAAYLAAVVLANSGLPHRSATRSFAEGLGWLAQIGLFVLLGLLVNPSELMDDLLPAILVGLVLLLVARPLSVVV 317
Cdd:COG3263 241 LGGSGFLAVYLAGLVLGNRRLPHKKSILRFHDGLAWLAQIGMFLMLGLLVFPSRLLPVALPALLIALFLIFVARPLAVFL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 318 SLIGFGVPWREQAFLSWAGLRGAVPVVLATFPIVAGVPDSYRLLNIVFVLVVVFTLVQGPSLRPVAHLLGLITREATREI 397
Cdd:COG3263 321 SLLPFRFSWREKLFISWVGLRGAVPIVLATFPLLAGLPGAQLIFNVVFFVVLVSLLVQGTTLPPVARKLGLEVPPEPKPL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 398 Q-VEAAPLDVLDAELLTMKVQPASRLRNVTILELRLPDPAVVTLIIRQGNTFVPLPDTRIEPGDELMIVTTSKTRALTES 476
Cdd:COG3263 401 TrVELELLEELDAELVEYRVPPGSPAVGKTLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALER 480
|
490 500
....*....|....*....|..
gi 491224303 477 RLRAVSRRGKLAYWFDEYGDVG 498
Cdd:COG3263 481 LFAAVSRAGTLAEWFGDRVRLG 502
|
|
| NhaP |
COG0025 |
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism]; |
10-433 |
6.57e-47 |
|
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 439796 [Multi-domain] Cd Length: 506 Bit Score: 170.15 E-value: 6.57e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 10 LLIGGLVLLASIVGTRVATRIGFPSLLFFLLVGVVLGeDGLGLEFD-NVELARNVCTAALAVILVEGGLTTRFADIRKVL 88
Cdd:COG0025 4 LLLILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLG-PGLGLELDpELGDLEPLLELFLPPLLFEAALNLDLRELRRNG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 89 APAGALATVGVVVSTVVTAFGAHVLLRMDWQLALLLGAIVSSTDAAAVFSVLRVLPLPRRLAGLLEAESGFNDAPAVILV 168
Cdd:COG0025 83 RPILRLAVVGVLLTTLAVALAAHWLLGLPLAAALLLGAILAPTDPVAVSPILRRLGVPKRLRTILEGESLLNDATALVLF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 169 LMFS--IVPFVFEPKSTAVQIVYELLAGSAIGLLCGFLGAMALRRvaLPASGLYPIATFGIGLVAFAASGTVHASGFIAA 246
Cdd:COG0025 163 VLALaaALGGGFSLGEALLDFLLAILGGILVGLLLGWLLGRLLRR--LPDPLLEILLTLALPFLAYLLAEALHGSGVLAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 247 YLAAVVLANSGLPHRSAT-----RSFAEGLGWLAQIGLFVLLGLLVNPSELMDDLLPAILVGLVLLLVARPLSVVVSLI- 320
Cdd:COG0025 241 VVAGLVLGNAGRRSLSPEtrlqlLEFWETLEFLLNSLLFVLLGAQLPLILLGALGLGGILLVLLALLVVRPLWVFLSLAl 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 321 -GFGVPWREQAFLSWAGLRGAVPVVLATFP---IVAGVPDSYRLLNIVFVLVVVFTLVQGPSLRPVAHLLGLITREATRE 396
Cdd:COG0025 321 rGSRLSWRERLFLSWGGPRGIVSLALALSLplhGGAGFPGRDLILALAFGVILLTLVLQGLTLPPLARRLGLREDEPEGE 400
|
410 420 430
....*....|....*....|....*....|....*..
gi 491224303 397 IQVEAAPLDVLDAELLTMKVQPASRLRNVTILELRLP 433
Cdd:COG0025 401 ELEAALARAALLELLAAELLADDEEVVLRAARRARRR 437
|
|
| Na_H_Exchanger |
pfam00999 |
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ... |
15-383 |
4.21e-22 |
|
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.
Pssm-ID: 425982 [Multi-domain] Cd Length: 377 Bit Score: 97.71 E-value: 4.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 15 LVLLASIVGTRVATRIGFPSLLFFLLVGVVLGEDGLGLEFDNVELARNVCTAALAVILVEGGLTTRFADIRKVLAPAGAL 94
Cdd:pfam00999 3 LLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSILLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 95 ATVGVVVSTVVTAFGAH-VLLRMDWQLALLLGAIVSSTDAAAVFSVLRVL-PLPRRLAGLLEAESGFNDAPAVILVLMF- 171
Cdd:pfam00999 83 ALLGVLIPFVLIGLLLYlLGLGIPLLEALLFGAILSATSPVVVLAILKELgRVPERLGTLLLGESVLNDGVAVVLLAVLl 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 172 ---SIVPFVFEPKSTAVQIVYELLAGSAIGLLCGFLGAMALRRVALPASgLYPIATFGIGLVAFAASGTVHASGFIAAYL 248
Cdd:pfam00999 163 alaQGVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLITRFTDDDRE-LEVLLVLLLALLAALLAEALGVSGILGAFL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 249 AAVVLANSGLPHRSATRSFAEGlGWLAQIGLFVLLGLLVNPSELMDDLLPAILVGLVLLLVARPLSVVVSLIGFGVPWRE 328
Cdd:pfam00999 242 AGLVLSEYPFANKLSEKLEPFG-YGLFNPLFFVLVGLSLDLSSLLLSVWILVLLALVAILLGRFLGVFLLLRLLGLSLRE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 491224303 329 QAFLSWAGL-RGAVPVVLATFPIVAGVPDSyRLLNIVFVLVVVFTLVQGPSLRPVA 383
Cdd:pfam00999 321 ALIIGFGGLqRGAVSLALAAIGPLLGIIAR-ELYPLLIVVVLFTVLVQGITLKPLL 375
|
|
| a_cpa1 |
TIGR00831 |
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC ... |
10-379 |
1.88e-13 |
|
Na+/H+ antiporter, bacterial form; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the bacterial members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 129911 [Multi-domain] Cd Length: 525 Bit Score: 72.61 E-value: 1.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 10 LLIGGLVLLASIVGTRVAT-RIGFPSLLffLLVGVVLGEDGLGLEfdnVELARNVCTAA-LAVILVEGGLTTRFADIRKV 87
Cdd:TIGR00831 1 VEIIELVMLATAVAVTVKFiRLPYPIAL--ILAGLLLGLAGLLPE---VPLDREIVLFLfLPPLLFEAAMNTDLRELREN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 88 LAPAGALATVGVVVSTVVTAFGAHVLLRMDWQLALLLGAIVSSTDAAAVFSVLRVLPLPRRLAGLLEAESGFNDAPAVIL 167
Cdd:TIGR00831 76 FRPIALIAFLLVVVTTVVVGFSLNWILGIPLALALILGAVLSPTDAVAVLGTFKSIRAPKKLSILLEGESLLNDGAALVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 168 ---VLMFSIVPFVFEPKSTAVQIVYELLAGSAIGLLCGFLGAMALRRvALPASGLYPIATFGIGLVAFAASGTVHASGFI 244
Cdd:TIGR00831 156 faiAVAVALGKGVFDPLNAALDFAVVCVGGIAAGLAVGYLAYRLLRA-KIDDPLVEIALTILAPFAGFLLAERFHFSGVI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 245 AAYLAAVVLANSGLPHRSATRSFAEGLGWLAQIG----LFVLLGLLVNPSELMDDLLPAILVGLVLLLVARPLSVVV--- 317
Cdd:TIGR00831 235 AVVAAGLILTNYGRDFSMSPTTRLIALDFWSVIVflvnGIIFILIGVQTPGTIFSAWKEILVAPAAVILALFTNAFViyp 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 318 --SLIGF-----------------GVPWREQAFLSWAGLRGAVPVVLA-----TFPIVAGVPDSYRLLNIVFVLVVVFTL 373
Cdd:TIGR00831 315 vmTYVRFlwtmkpfsnrflkkkpmEFGTRWKHVVSWAGLRGAIPLALAlsfpnQLLSGMAFPARYELVFLAAGVILFSLL 394
|
....*.
gi 491224303 374 VQGPSL 379
Cdd:TIGR00831 395 VQGISL 400
|
|
| KefB |
COG0475 |
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ... |
10-241 |
4.45e-10 |
|
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];
Pssm-ID: 440243 [Multi-domain] Cd Length: 384 Bit Score: 61.32 E-value: 4.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 10 LLIGGLVLLASIVGTRVATRIGFPSLLFFLLVGVVLGEDGLGLeFDNVELARNVCTAALAVILVEGGLTTRFADIRKVLA 89
Cdd:COG0475 6 LLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGL-IEDSEALELLAELGVVLLLFLIGLELDLKRLRKMGR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 90 PAGALAtVGVVVSTVVTAFGAHVLLRMDWQLALLLGAIVSSTDAAAVFSVLRVLPLPRRLAG-LLEAESGFNDapaVILV 168
Cdd:COG0475 85 RALGIG-LLQVLLPFLLGFLLALLLGLSLAAALFLGAALAATSTAIVLKVLKELGLLKTPLGqLILGVALFDD---IAAI 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491224303 169 LMFSIVPFVFEPKSTAVQIVYELLAGSAIGLLCGFLGAMALRRV-----ALPASGLYPIATFGIGLVAFAASGTVHAS 241
Cdd:COG0475 161 LLLALVPALAGGGSVAGSLLLALLKALLFLALLLLVGRYLLRRLfrlvaRTRSRELFLLFALLLVLLAAALAELLGLS 238
|
|
| trkA |
PRK09496 |
Trk system potassium transporter TrkA; |
408-469 |
1.10e-07 |
|
Trk system potassium transporter TrkA;
Pssm-ID: 236541 [Multi-domain] Cd Length: 453 Bit Score: 53.97 E-value: 1.10e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491224303 408 DAELLTMKVQPASRLRNVTILELRLPDPAVVTLIIRQGNTFVPLPDTRIEPGDELMIVTTSK 469
Cdd:PRK09496 377 AAEAIEAVAHETSKVVGKPLKDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVFVLDK 438
|
|
| trkA |
PRK09496 |
Trk system potassium transporter TrkA; |
388-469 |
2.15e-07 |
|
Trk system potassium transporter TrkA;
Pssm-ID: 236541 [Multi-domain] Cd Length: 453 Bit Score: 53.20 E-value: 2.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 388 LITREATREIQVEAApLDVLD-----AELLTMKVQPASRLRNVTILELR---LPDPAVVTLIIRQGNTFVPLPDTRIEPG 459
Cdd:PRK09496 127 LVAREIARLIEYPGA-LDVEEfadgrVQLVEVKVYEGSPLVGKPLSDLRehfPDIDVRVVAIFRGGRLIIPRGDTVIEAG 205
|
90
....*....|
gi 491224303 460 DELMIVTTSK 469
Cdd:PRK09496 206 DEVYFIGARE 215
|
|
| TrkA |
COG0569 |
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ... |
388-462 |
1.37e-06 |
|
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 440335 [Multi-domain] Cd Length: 296 Bit Score: 50.07 E-value: 1.37e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491224303 388 LITREATREIQVEAAPLDVLDAELLTMKVQPASRLRNVTILELRLPDP--AVVTLIIRQGNTFVPLPDTRIEPGDEL 462
Cdd:COG0569 219 RIARLLLRPGVLDVLELADGDAEIVEVTVPEGSPLVGKTLKELDLRERygVTVVAIKRGGEVIIPSGDTVLEAGDEL 295
|
|
| TrkA_C |
pfam02080 |
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ... |
411-478 |
3.85e-06 |
|
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.
Pssm-ID: 460440 [Multi-domain] Cd Length: 70 Bit Score: 44.52 E-value: 3.85e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 411 LLTMKVQPASRLRNVTILELRLPDP--AVVTLIIRQGNTFVPLPDTRIEPGDELMIVTTSKTRALTESRL 478
Cdd:pfam02080 1 LVEVTVPENSPLVGKTLKELNLPERfgVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
|
|
| b_cpa1 |
TIGR00840 |
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A. ... |
121-411 |
3.92e-06 |
|
sodium/hydrogen exchanger 3; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36)The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals.Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in(1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles.This model is specific for the eukaryotic members members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273294 [Multi-domain] Cd Length: 559 Bit Score: 49.39 E-value: 3.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 121 ALLLGAIVSSTDAAAVFSVLRVLPLPRRLAGLLEAESGFNDAPAVILVLMF-SIVPFVFEP-------KSTAVQIVYeLL 192
Cdd:TIGR00840 134 NLLFGSLISAVDPVAVLAVFEEYHVNEKLYIIIFGESLLNDAVTVVLYNTFiKFHKTADEPvtivdvfEGCASFFVV-TC 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 193 AGSAIGLLCGFLGAMALRRVALpASGLYPIATFGIGLVAFAASGTVHASGFIAAYLAAVVL---ANSGLPHRSAT--RSF 267
Cdd:TIGR00840 213 GGLLVGVVFGFLVAFITRFTHH-IRQIEPLFVFLISYLSYLFAETLHLSGILALIFCGITMkkyVEANMSRRSQTtiKYF 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 268 AEGLGWLAQ-IGLFVLLGLLVNPSELMDDLLpaILVGLVLLLVARPLsVVVSLIGF-------GVPWREQAFLSWAGLRG 339
Cdd:TIGR00840 292 MKMLSSLSEtLIFIFLGVSLVTENHEWNWAF--VVATLSFCVIYRVL-GVRTLSWItnefrpvEIPYKDQLVIFYAGLRG 368
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491224303 340 AVPVVLATFPIVAGVPDSYRLLNIVFVLVVVFTLVQGPSLRPVAHLLGLITREATREIQVEAAPLDVLDAEL 411
Cdd:TIGR00840 369 AVAFALALLLDEKIFPYKFLFVTTTLVVVFFTVIFQGGTIKPLVEVLKVKKGCISKTKINEELHDREFDHLL 440
|
|
| c_cpa1 |
TIGR00844 |
na(+)/h(+) antiporter; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The ... |
116-210 |
4.62e-04 |
|
na(+)/h(+) antiporter; The Monovalent Cation:Proton Antiporter-1 (CPA1) Family (TC 2.A.36) The CPA1 family is a large family of proteins derived from Gram-positive and Gram-negative bacteria, blue green bacteria, yeast, plants and animals. Transporters from eukaryotes have been functionally characterized, and all of these catalyze Na+:H+ exchange. Their primary physiological functions may be in (1) cytoplasmic pH regulation, extruding the H+ generated during metabolism, and (2) salt tolerance (in plants), due to Na+ uptake into vacuoles. This model is specific for the fungal members of this family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273295 [Multi-domain] Cd Length: 810 Bit Score: 42.99 E-value: 4.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 116 MDWQLALLLGAIVSSTD---AAAVFSVLRVLPLPRRLAGLLEAESGFNDAPAVILVlmFSIVPFVFEPKS--------TA 184
Cdd:TIGR00844 128 LNFPASLLMGACITATDpvlAQSVVSGTFAQKVPGHLRNLLSCESGCNDGLAFPFV--FLSMDLLLYPGRggeivkdwIC 205
|
90 100
....*....|....*....|....*.
gi 491224303 185 VQIVYELLAGSAIGLLCGFLGAMALR 210
Cdd:TIGR00844 206 VTILWECIFGSILGCIIGYCGRKAIR 231
|
|
| KhtT |
COG0490 |
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ... |
342-478 |
1.23e-03 |
|
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];
Pssm-ID: 440256 [Multi-domain] Cd Length: 140 Bit Score: 39.14 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 342 PVVLATFPIVAGVPDSYRLLNIVFVLVVVFTLVQGPSLRPVAHLLGLITREATREIQVEAAPLDVLDAELLTMKVQPASR 421
Cdd:COG0490 1 AALALLLLLIILLLLLALAALLVAIVIVGVLGLILRGLLLLELALLLLLLGELLRLLTRLLIELVLLLAIEEVKVPPGSP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224303 422 LRNVTILELRLPDP--AVVTLIIRQGNTFV-PLPDTRIEPGDELMIVTTSKTRALTESRL 478
Cdd:COG0490 81 LVGKTLGELNLRQRtgVTVVAIRRGGEVILsPGPDTVLEAGDTLVVVGTREQLERLEELL 140
|
|
| |
