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Conserved domains on  [gi|491224571|ref|WP_005082859|]
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MULTISPECIES: cell division protein CrgA [Mycobacteroides]

Protein Classification

cell division protein CrgA( domain architecture ID 10011286)

cell division protein CrgA plays an important role in septal peptidoglycan synthesis and cell shape morphogenesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00159 PRK00159
putative septation inhibitor protein; Reviewed
 1-87 1.09e-48

putative septation inhibitor protein; Reviewed


:

Pssm-ID: 178907  Cd Length: 87  Bit Score: 148.63  E-value: 1.09e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224571  1 MPKSKVRKKSAFNATTVSRTPVKVKAGPSSVWFVAFFLTLMLIGLAWLMVFQLAAQHITWMLDLGPWNYAIAFAFMITGL 80
Cdd:PRK00159  1 MPKSKVRKKNDFTVSSVSRTPVKVKAGPSSVWYVVLMLGLMLIGLAWLVVNYLAGPAIPWMADLGPWNYAIGFALMITGL 80


                ....*..
gi 491224571 81 LLTMRWR 87
Cdd:PRK00159 81 LMTMRWR 87
 
Name Accession Description Interval E-value
PRK00159 PRK00159
putative septation inhibitor protein; Reviewed
 1-87 1.09e-48

putative septation inhibitor protein; Reviewed


Pssm-ID: 178907  Cd Length: 87  Bit Score: 148.63  E-value: 1.09e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224571  1 MPKSKVRKKSAFNATTVSRTPVKVKAGPSSVWFVAFFLTLMLIGLAWLMVFQLAAQHITWMLDLGPWNYAIAFAFMITGL 80
Cdd:PRK00159  1 MPKSKVRKKNDFTVSSVSRTPVKVKAGPSSVWYVVLMLGLMLIGLAWLVVNYLAGPAIPWMADLGPWNYAIGFALMITGL 80


                ....*..
gi 491224571 81 LLTMRWR 87
Cdd:PRK00159 81 LMTMRWR 87
CrgA pfam06781
Cell division protein CrgA; CrgA is a trans-membrane (TM) protein, first described in ...
 1-87 5.68e-36

Cell division protein CrgA; CrgA is a trans-membrane (TM) protein, first described in Streptomyces as being required for sporulation through the coordination of several aspects of reproductive growth. In Mtb (Mycobacterium tuberculosis ) CrgA is a central component of the divisome, and consists of 93 residues with two predicted TM helices (TM1: residues 29-51; and TM2: residues 66-88). CrgA facilitates the recruitment of the proteins essential for peptidoglycan synthesis to the divisome and also stabilizes the divisome. Reduced production of CrgA results in elongated cells and reduced growth rate, and loss of CrgA impairs peptidoglycan synthesis. CrgA has homologs in other actinomycetes.


Pssm-ID: 429115  Cd Length: 88  Bit Score: 116.59  E-value: 5.68e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224571   1 MPKSKVRKKSAFNATTVSRTPVKVKA-GPSSVWFVAFFLTLMLIGLAWLMVFQLAAQHITWMLDLGPWNYAIAFAFMITG 79
Cdd:pfam06781  1 MPKSKVRKKAVYTPPTARRTPVKAKAaKPSPRWYAPVMLGLMLLGLLWLVVYYLAGGPIPFMADLGNWNLAIGFGLIIVG 80


                 ....*...
gi 491224571  80 LLLTMRWR 87
Cdd:pfam06781 81 LLMTTRWR 88
 
Name Accession Description Interval E-value
PRK00159 PRK00159
putative septation inhibitor protein; Reviewed
 1-87 1.09e-48

putative septation inhibitor protein; Reviewed


Pssm-ID: 178907  Cd Length: 87  Bit Score: 148.63  E-value: 1.09e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224571  1 MPKSKVRKKSAFNATTVSRTPVKVKAGPSSVWFVAFFLTLMLIGLAWLMVFQLAAQHITWMLDLGPWNYAIAFAFMITGL 80
Cdd:PRK00159  1 MPKSKVRKKNDFTVSSVSRTPVKVKAGPSSVWYVVLMLGLMLIGLAWLVVNYLAGPAIPWMADLGPWNYAIGFALMITGL 80


                ....*..
gi 491224571 81 LLTMRWR 87
Cdd:PRK00159 81 LMTMRWR 87
CrgA pfam06781
Cell division protein CrgA; CrgA is a trans-membrane (TM) protein, first described in ...
 1-87 5.68e-36

Cell division protein CrgA; CrgA is a trans-membrane (TM) protein, first described in Streptomyces as being required for sporulation through the coordination of several aspects of reproductive growth. In Mtb (Mycobacterium tuberculosis ) CrgA is a central component of the divisome, and consists of 93 residues with two predicted TM helices (TM1: residues 29-51; and TM2: residues 66-88). CrgA facilitates the recruitment of the proteins essential for peptidoglycan synthesis to the divisome and also stabilizes the divisome. Reduced production of CrgA results in elongated cells and reduced growth rate, and loss of CrgA impairs peptidoglycan synthesis. CrgA has homologs in other actinomycetes.


Pssm-ID: 429115  Cd Length: 88  Bit Score: 116.59  E-value: 5.68e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224571   1 MPKSKVRKKSAFNATTVSRTPVKVKA-GPSSVWFVAFFLTLMLIGLAWLMVFQLAAQHITWMLDLGPWNYAIAFAFMITG 79
Cdd:pfam06781  1 MPKSKVRKKAVYTPPTARRTPVKAKAaKPSPRWYAPVMLGLMLLGLLWLVVYYLAGGPIPFMADLGNWNLAIGFGLIIVG 80


                 ....*...
gi 491224571  80 LLLTMRWR 87
Cdd:pfam06781 81 LLMTTRWR 88
PRK02251 PRK02251
cell division protein CrgA;
1-87 1.34e-15

cell division protein CrgA;


Pssm-ID: 179394  Cd Length: 87  Bit Score: 65.13  E-value: 1.34e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491224571  1 MPKSKVRKKSAFNATTVSRTPVKVKAGPSS-VWFVAFFLTLMLIGLAWLMVFQLAAQHITwMLDLGPWNYAIAFAFMITG 79
Cdd:PRK02251  1 MPKSQVRKMADRQAPPTKRAEESIKGTKSNpRWFVPLFVALMIIGLIWLVVYYLSNGSLP-IPALGAWNLVIGFGLIMAG 79


                ....*...
gi 491224571 80 LLLTMRWR 87
Cdd:PRK02251 80 FGMTTQWK 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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