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Conserved domains on  [gi|491228766|ref|WP_005087039|]
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putative RNA methyltransferase [Acinetobacter haemolyticus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 1-266 6.62e-92

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member PRK11088:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 272  Bit Score: 272.56  E-value: 6.62e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   1 MSLLmCPVCRQALHLAENAWRCENGHSYDVAKQGYVNLHVVQHKHSKTPGDTPESVLARREFLQAGFYQPLQQTVVALLQ 80
Cdd:PRK11088   1 MSYQ-CPLCHQPLTLEENSWICPQNHQFDCAKEGYVNLLPVQHKRSKDPGDNKEMMQARRAFLDAGHYQPLRDAVANLLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  81 QLQP---KSVLDIGCGEGYYTSAMQGC-----TDQCVGVDIAKTAIQRAAKLNANVTWVIGTGATLPVQDRTIDVCTSLF 152
Cdd:PRK11088  80 ERLDekaTALLDIGCGEGYYTHALADAlpeitTMQLFGLDISKVAIKYAAKRYPQVTFCVASSHRLPFADQSLDAIIRIY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766 153 SPIPQSEIVRVLRENGYLIVVTPAPRHLYELREALFEQVTLHEPQKfvEQLAAqFKLVQSQCVEAPMLLDQYALKNLIAM 232
Cdd:PRK11088 160 APCKAEELARVVKPGGIVITVTPGPRHLFELKGLIYDEVRLHAPEA--EQLEG-FELQHSERLAYPMRLTGSEAVALLQM 236

                        250       260       270
                 ....*....|....*....|....*....|....
gi 491228766 233 TPYAYKANPERRMKLEQVQQFSVIAAFQIYVFEK 266
Cdd:PRK11088 237 TPFAWKATPEVKQQLAAKGVFSCETDFNIRVYRR 270
 
Name Accession Description Interval E-value
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 1-266 6.62e-92

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 272.56  E-value: 6.62e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   1 MSLLmCPVCRQALHLAENAWRCENGHSYDVAKQGYVNLHVVQHKHSKTPGDTPESVLARREFLQAGFYQPLQQTVVALLQ 80
Cdd:PRK11088   1 MSYQ-CPLCHQPLTLEENSWICPQNHQFDCAKEGYVNLLPVQHKRSKDPGDNKEMMQARRAFLDAGHYQPLRDAVANLLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  81 QLQP---KSVLDIGCGEGYYTSAMQGC-----TDQCVGVDIAKTAIQRAAKLNANVTWVIGTGATLPVQDRTIDVCTSLF 152
Cdd:PRK11088  80 ERLDekaTALLDIGCGEGYYTHALADAlpeitTMQLFGLDISKVAIKYAAKRYPQVTFCVASSHRLPFADQSLDAIIRIY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766 153 SPIPQSEIVRVLRENGYLIVVTPAPRHLYELREALFEQVTLHEPQKfvEQLAAqFKLVQSQCVEAPMLLDQYALKNLIAM 232
Cdd:PRK11088 160 APCKAEELARVVKPGGIVITVTPGPRHLFELKGLIYDEVRLHAPEA--EQLEG-FELQHSERLAYPMRLTGSEAVALLQM 236

                        250       260       270
                 ....*....|....*....|....*....|....
gi 491228766 233 TPYAYKANPERRMKLEQVQQFSVIAAFQIYVFEK 266
Cdd:PRK11088 237 TPFAWKATPEVKQQLAAKGVFSCETDFNIRVYRR 270
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 65-187 1.32e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 93.13  E-value: 1.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  65 AGFYQPLQQtVVALLQQLQPKSVLDIGCGEGYYTSAMQGCTDQCVGVDIAKTAI----QRAAKLNANVTWVIGTGATLPV 140
Cdd:COG2226    5 AARYDGREA-LLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLelarERAAEAGLNVEFVVGDAEDLPF 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 491228766 141 QDRTIDVCTSLFS----PIPQ---SEIVRVLRENGYLIVVTPAPRHLYELREAL 187
Cdd:COG2226   84 PDGSFDLVISSFVlhhlPDPEralAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 87-168 1.04e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 70.67  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   87 VLDIGCGEGYYTSAM-QGCTDQCVGVDIAKTAI----QRAAKLNANVTWVIGTGATLPVQDRTIDVCTSLFS----PIPQ 157
Cdd:pfam13649   1 VLDLGCGTGRLTLALaRRGGARVTGVDLSPEMLerarERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVlhhlPDPD 80

                          90
                  ....*....|....*.
gi 491228766  158 -----SEIVRVLRENG 168
Cdd:pfam13649  81 leaalREIARVLKPGG 96
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 68-211 5.23e-15

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 72.32  E-value: 5.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   68 YQPLQQTV----VALLQQL---QPKSVLDIGCGEGYYTSAM--QGCTDQCVGVDIAKTAIQRAA-KLNANVTWVIGTGAT 137
Cdd:TIGR02072  12 HAKIQREMakrlLALLKEKgifIPASVLDIGCGTGYLTRALlkRFPQAEFIALDISAGMLAQAKtKLSENVQFICGDAEK 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  138 LPVQDRTIDVCTS-----LFSPIPQ--SEIVRVLRENGYLIVVTPAPRHLYELREaLFEQVTLHEP--QKFVEQLAAQFK 208
Cdd:TIGR02072  92 LPLEDSSFDLIVSnlalqWCDDLSQalSELARVLKPGGLLAFSTFGPGTLHELRQ-SFGQHGLRYLslDELKALLKNSFE 170


                  ...
gi 491228766  209 LVQ 211
Cdd:TIGR02072 171 LLT 173
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 87-173 7.44e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.43  E-value: 7.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  87 VLDIGCGEGYYTSAM-QGCTDQCVGVDIAKTAIQRAAKLNA-----NVTWVIGTGATLP-VQDRTIDV--CTSLFSPIPQ 157
Cdd:cd02440    2 VLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAalladNVEVLKGDAEELPpEADESFDViiSDPPLHHLVE 81

                         90       100
                 ....*....|....*....|..
gi 491228766 158 S------EIVRVLRENGYLIVV 173
Cdd:cd02440   82 DlarfleEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
rrmA PRK11088
23S rRNA methyltransferase A; Provisional
 1-266 6.62e-92

23S rRNA methyltransferase A; Provisional


Pssm-ID: 236841 [Multi-domain]  Cd Length: 272  Bit Score: 272.56  E-value: 6.62e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   1 MSLLmCPVCRQALHLAENAWRCENGHSYDVAKQGYVNLHVVQHKHSKTPGDTPESVLARREFLQAGFYQPLQQTVVALLQ 80
Cdd:PRK11088   1 MSYQ-CPLCHQPLTLEENSWICPQNHQFDCAKEGYVNLLPVQHKRSKDPGDNKEMMQARRAFLDAGHYQPLRDAVANLLA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  81 QLQP---KSVLDIGCGEGYYTSAMQGC-----TDQCVGVDIAKTAIQRAAKLNANVTWVIGTGATLPVQDRTIDVCTSLF 152
Cdd:PRK11088  80 ERLDekaTALLDIGCGEGYYTHALADAlpeitTMQLFGLDISKVAIKYAAKRYPQVTFCVASSHRLPFADQSLDAIIRIY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766 153 SPIPQSEIVRVLRENGYLIVVTPAPRHLYELREALFEQVTLHEPQKfvEQLAAqFKLVQSQCVEAPMLLDQYALKNLIAM 232
Cdd:PRK11088 160 APCKAEELARVVKPGGIVITVTPGPRHLFELKGLIYDEVRLHAPEA--EQLEG-FELQHSERLAYPMRLTGSEAVALLQM 236

                        250       260       270
                 ....*....|....*....|....*....|....
gi 491228766 233 TPYAYKANPERRMKLEQVQQFSVIAAFQIYVFEK 266
Cdd:PRK11088 237 TPFAWKATPEVKQQLAAKGVFSCETDFNIRVYRR 270
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 65-187 1.32e-23

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 93.13  E-value: 1.32e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  65 AGFYQPLQQtVVALLQQLQPKSVLDIGCGEGYYTSAMQGCTDQCVGVDIAKTAI----QRAAKLNANVTWVIGTGATLPV 140
Cdd:COG2226    5 AARYDGREA-LLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLelarERAAEAGLNVEFVVGDAEDLPF 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 491228766 141 QDRTIDVCTSLFS----PIPQ---SEIVRVLRENGYLIVVTPAPRHLYELREAL 187
Cdd:COG2226   84 PDGSFDLVISSFVlhhlPDPEralAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 75-175 5.67e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 75.05  E-value: 5.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  75 VVALLQQL--QPKSVLDIGCGEGYYTSAMQGCTDQCVGVDIAKTAIQRAAKLNA--NVTWVIGTGATLPVQDRTIDV--C 148
Cdd:COG2227   14 LAALLARLlpAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAelNVDFVQGDLEDLPLEDGSFDLviC 93

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491228766 149 TSLFSPIPQ-----SEIVRVLRENGYLIVVTP 175
Cdd:COG2227   94 SEVLEHLPDpaallRELARLLKPGGLLLLSTP 125
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 87-168 1.04e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 70.67  E-value: 1.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   87 VLDIGCGEGYYTSAM-QGCTDQCVGVDIAKTAI----QRAAKLNANVTWVIGTGATLPVQDRTIDVCTSLFS----PIPQ 157
Cdd:pfam13649   1 VLDLGCGTGRLTLALaRRGGARVTGVDLSPEMLerarERAAEAGLNVEFVQGDAEDLPFPDGSFDLVVSSGVlhhlPDPD 80

                          90
                  ....*....|....*.
gi 491228766  158 -----SEIVRVLRENG 168
Cdd:pfam13649  81 leaalREIARVLKPGG 96
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 68-211 5.23e-15

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 72.32  E-value: 5.23e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   68 YQPLQQTV----VALLQQL---QPKSVLDIGCGEGYYTSAM--QGCTDQCVGVDIAKTAIQRAA-KLNANVTWVIGTGAT 137
Cdd:TIGR02072  12 HAKIQREMakrlLALLKEKgifIPASVLDIGCGTGYLTRALlkRFPQAEFIALDISAGMLAQAKtKLSENVQFICGDAEK 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  138 LPVQDRTIDVCTS-----LFSPIPQ--SEIVRVLRENGYLIVVTPAPRHLYELREaLFEQVTLHEP--QKFVEQLAAQFK 208
Cdd:TIGR02072  92 LPLEDSSFDLIVSnlalqWCDDLSQalSELARVLKPGGLLAFSTFGPGTLHELRQ-SFGQHGLRYLslDELKALLKNSFE 170


                  ...
gi 491228766  209 LVQ 211
Cdd:TIGR02072 171 LLT 173
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 88-172 1.02e-14

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 68.08  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   88 LDIGCGEGYYTSAMQGCTDQCVGVDIAKTAIQRAAKL--NANVTWVIGTGATLPVQDRTIDVCTSLFS----PIPQ---S 158
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREKapREGLTFVVGDAEDLPFPDNSFDLVLSSEVlhhvEDPEralR 80

                          90
                  ....*....|....
gi 491228766  159 EIVRVLRENGYLIV 172
Cdd:pfam08241  81 EIARVLKPGGILII 94
PRK08317 PRK08317
hypothetical protein; Provisional
 67-175 1.62e-13

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 68.04  E-value: 1.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  67 FYQPLQQTVVALLQqLQP-KSVLDIGCGEGYYTSAMQ---GCTDQCVGVDIA----KTAIQRAAKLNANVTWVIGTGATL 138
Cdd:PRK08317   3 DFRRYRARTFELLA-VQPgDRVLDVGCGPGNDARELArrvGPEGRVVGIDRSeamlALAKERAAGLGPNVEFVRGDADGL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 491228766 139 PVQDRTIDVCTSL--FSPIPQ-----SEIVRVLRENGYLIVVTP 175
Cdd:PRK08317  82 PFPDGSFDAVRSDrvLQHLEDparalAEIARVLRPGGRVVVLDT 125
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
69-200 8.04e-13

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 65.02  E-value: 8.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  69 QPLQQTVVALLQQLQPKSVLDIGCGEGYYTSAMQGCTDQCVGVDIAKTAIQRAAKLNANVTWVIGTGATLPVQDRTID-- 146
Cdd:COG4976   32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDRLLVADLADLAEPDGRFDli 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491228766 147 VCTSLFSPIP-----QSEIVRVLRENGYLI--VVTPAPRHLYELR----EALFEQVTLHEPQKFV 200
Cdd:COG4976  112 VAADVLTYLGdlaavFAGVARALKPGGLFIfsVEDADGSGRYAHSldyvRDLLAAAGFEVPGLLV 176
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
83-174 2.80e-11

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 58.68  E-value: 2.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  83 QPKSVLDIGCGEGYYTSAMQGCTDQC--VGVDIAKTAIQRAAKLNANVTWVIGTGATLPVqDRTID--VCTSLFSPIPQ- 157
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPGArvTGVDLSPEMLARARARLPNVRFVVADLRDLDP-PEPFDlvVSNAALHWLPDh 79

                         90       100
                 ....*....|....*....|.
gi 491228766 158 ----SEIVRVLRENGYLIVVT 174
Cdd:COG4106   80 aallARLAAALAPGGVLAVQV 100
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 69-238 1.65e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 59.16  E-value: 1.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  69 QPLQQTVVALLQQL-QPKSVLDIGCGEGYYTSAM-QGCTDQCVGVDIAKTAIQRAAKLNA-----NVTWVIGTGA-TLPV 140
Cdd:COG0500   11 LPGLAALLALLERLpKGGRVLDLGCGTGRNLLALaARFGGRVIGIDLSPEAIALARARAAkaglgNVEFLVADLAeLDPL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766 141 QDRTID--VCTSLFSPIPQS-------EIVRVLRENG--YLIVVTPAPRHLYELREALFEQVTLHEPQKFVEQLAAQFKL 209
Cdd:COG0500   91 PAESFDlvVAFGVLHHLPPEereallrELARALKPGGvlLLSASDAAAALSLARLLLLATASLLELLLLLRLLALELYLR 170

                        170       180
                 ....*....|....*....|....*....
gi 491228766 210 VQSQCVEAPMLLDQYALKNLIAMTPYAYK 238
Cdd:COG0500  171 ALLAAAATEDLRSDALLESANALEYLLSK 199
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 85-191 1.02e-09

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 55.89  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   85 KSVLDIGCGEGYYTSAM---QGCTDQCVGVDIAKTAIQRA----AKLN-ANVTWVIGTGATLP--VQDRTIDV----CTS 150
Cdd:pfam13847   5 MRVLDLGCGTGHLSFELaeeLGPNAEVVGIDISEEAIEKArenaQKLGfDNVEFEQGDIEELPelLEDDKFDVvisnCVL 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 491228766  151 LFSPIPQS---EIVRVLRENGYLIVVTP-----APRHLYELREALFEQV 191
Cdd:pfam13847  85 NHIPDPDKvlqEILRVLKPGGRLIISDPdslaeLPAHVKEDSTYYAGCV 133
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 87-173 7.44e-09

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 52.43  E-value: 7.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  87 VLDIGCGEGYYTSAM-QGCTDQCVGVDIAKTAIQRAAKLNA-----NVTWVIGTGATLP-VQDRTIDV--CTSLFSPIPQ 157
Cdd:cd02440    2 VLDLGCGTGALALALaSGPGARVTGVDISPVALELARKAAAalladNVEVLKGDAEELPpEADESFDViiSDPPLHHLVE 81

                         90       100
                 ....*....|....*....|..
gi 491228766 158 S------EIVRVLRENGYLIVV 173
Cdd:cd02440   82 DlarfleEARRLLKPGGVLVLT 103
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 73-172 3.33e-07

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 50.15  E-value: 3.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  73 QTVVALLQQLQPKSVLDIGCGEGYYTSAMQ---GCTDQCVGVDIA----KTAIQRAAKLN--ANVTWVIGTGATLPVQDR 143
Cdd:PRK00216  41 RKTIKWLGVRPGDKVLDLACGTGDLAIALAkavGKTGEVVGLDFSegmlAVGREKLRDLGlsGNVEFVQGDAEALPFPDN 120

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491228766 144 TIDVCTSLF-----SPIPQ--SEIVRVLRENGYLIV 172
Cdd:PRK00216 121 SFDAVTIAFglrnvPDIDKalREMYRVLKPGGRLVI 156
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 72-175 9.27e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 41.84  E-value: 9.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  72 QQTVVALLQQLQPK---SVLDIGCGEGYYTSAM---QGCtdQCVGVDIAKTAIQRA------AKLNANVTWVIGTGATLP 139
Cdd:COG2230   37 EAKLDLILRKLGLKpgmRVLDIGCGWGGLALYLarrYGV--RVTGVTLSPEQLEYAreraaeAGLADRVEVRLADYRDLP 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 491228766 140 VqDRTIDVCTS--------------LFspipqSEIVRVLRENGYLIVVTP 175
Cdd:COG2230  115 A-DGQFDAIVSigmfehvgpenypaYF-----AKVARLLKPGGRLLLHTP 158
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 83-184 1.24e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 41.64  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   83 QPKSVLDIGCGEGYYTSAMQGCTDQCVGVDIAKTAIQRaAKLNANVTWVIGTGATlpVQDRTIDV--CTSLFSPIPQSE- 159
Cdd:pfam13489  22 SPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIER-ALLNVRFDQFDEQEAA--VPAGKFDVivAREVLEHVPDPPa 98

                          90       100
                  ....*....|....*....|....*....
gi 491228766  160 ----IVRVLRENGYLIVVTPAPRHLYELR 184
Cdd:pfam13489  99 llrqIAALLKPGGLLLLSTPLASDEADRL 127
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 69-136 1.85e-04

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 41.23  E-value: 1.85e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491228766  69 QPLqqTVVALLQQLQPKS---VLDIGCGEGYYTSAMQGCTDQCVGVDI----AKTAIQRAAKLN-ANVTWVIGTGA 136
Cdd:COG2518   51 QPY--IVARMLEALDLKPgdrVLEIGTGSGYQAAVLARLAGRVYSVERdpelAERARERLAALGyDNVTVRVGDGA 124
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 88-170 2.02e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 39.66  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   88 LDIGCGEGYYTSAMQGCTDQC--VGVDIAKTAIQRAAKL--------NANVTWVIGTGATLPvqDRTIDV--CTSLFSPI 155
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLeyTGLDISPAALEAARERlaalgllnAVRVELFQLDLGELD--PGSFDVvvASNVLHHL 78

                          90       100
                  ....*....|....*....|
gi 491228766  156 PQ-----SEIVRVLRENGYL 170
Cdd:pfam08242  79 ADpravlRNIRRLLKPGGVL 98
PLN02244 PLN02244
tocopherol O-methyltransferase
 81-187 2.68e-04

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 41.65  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  81 QLQPKSVLDIGCGEG---YYTSAMQGCtdQCVGVDIAKTAIQRAAKLNA------NVTWVIGTGATLPVQDRTIDVCTSL 151
Cdd:PLN02244 116 EKRPKRIVDVGCGIGgssRYLARKYGA--NVKGITLSPVQAARANALAAaqglsdKVSFQVADALNQPFEDGQFDLVWSM 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491228766 152 FSP--IPQ-----SEIVRVLRENGYLIVVTPAPRHLYELREAL 187
Cdd:PLN02244 194 ESGehMPDkrkfvQELARVAAPGGRIIIVTWCHRDLEPGETSL 236
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 77-171 4.96e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 40.71  E-value: 4.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766   77 ALLQQLQP-KSVLDIGCGEGYYT--SAMQGcTDQCVGVDIAKTAIqRAAKLNA---NVTWVIGTGATLPVQDRTID--VC 148
Cdd:pfam06325 154 ALERLVKPgESVLDVGCGSGILAiaALKLG-AKKVVGVDIDPVAV-RAAKENAelnGVEARLEVYLPGDLPKEKADvvVA 231

                          90       100
                  ....*....|....*....|....*
gi 491228766  149 TSLFSPIPQ--SEIVRVLRENGYLI 171
Cdd:pfam06325 232 NILADPLIElaPDIYALVKPGGYLI 256
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
79-112 2.70e-03

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 38.69  E-value: 2.70e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 491228766  79 LQQLQPKSVLDIGCGEGYYTSAMQG-CTDQCVGVD 112
Cdd:PRK15068 118 LSPLKGRTVLDVGCGNGYHMWRMLGaGAKLVVGID 152
arsM PRK11873
arsenite methyltransferase;
79-174 3.74e-03

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 38.01  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  79 LQQLQP-KSVLDIGCGEGY--YTSAMQ-GCTDQCVGVDIAKTAIQRAaKLNA------NVTWVIGTGATLPVQDRTIDV- 147
Cdd:PRK11873  72 LAELKPgETVLDLGSGGGFdcFLAARRvGPTGKVIGVDMTPEMLAKA-RANArkagytNVEFRLGEIEALPVADNSVDVi 150

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491228766 148 ---CTSLFSPIPQ---SEIVRVLRENGYL----IVVT 174
Cdd:PRK11873 151 isnCVINLSPDKErvfKEAFRVLKPGGRFaisdVVLR 187
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
77-171 4.73e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 37.44  E-value: 4.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  77 ALLQQLQP-KSVLDIGCGEGYY--TSAMQGCTdQCVGVDIAKTAIqRAAKLNA---NVTWVIgtgaTLPVQDRTID--VC 148
Cdd:PRK00517 112 ALEKLVLPgKTVLDVGCGSGILaiAAAKLGAK-KVLAVDIDPQAV-EAARENAelnGVELNV----YLPQGDLKADviVA 185

                         90       100
                 ....*....|....*....|....*..
gi 491228766 149 TSLFSPI----PQseIVRVLRENGYLI 171
Cdd:PRK00517 186 NILANPLlelaPD--LARLLKPGGRLI 210
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
85-147 5.24e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 37.19  E-value: 5.24e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491228766  85 KSVLDIGCGEGY--YTSAMQGCtDQCVGVDIAKTAIQRAA----KLNANVTWVIGTGATLPVqDRTIDV 147
Cdd:COG2263   47 KTVLDLGCGTGMlaIGAALLGA-KKVVGVDIDPEALEIARenaeRLGVRVDFIRADVTRIPL-GGSVDT 113
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 73-186 5.98e-03

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 37.43  E-value: 5.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491228766  73 QTVVALLQQLQPKSVLDIGCGEGYYTSAMQGCTDQCVGVDIAKTAIQRAAKLNANVTWVIGTGATLPVQDRTIDV----- 147
Cdd:PRK10258  32 DALLAMLPQRKFTHVLDAGCGPGWMSRYWRERGSQVTALDLSPPMLAQARQKDAADHYLAGDIESLPLATATFDLawsnl 111

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491228766 148 ----CTSLFSPIpqSEIVRVLRENGYLIVVTPAPRHLYELREA 186
Cdd:PRK10258 112 avqwCGNLSTAL--RELYRVVRPGGVVAFTTLVQGSLPELHQA 152
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 73-112 7.53e-03

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 37.38  E-value: 7.53e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 491228766   73 QTVVALLQQLQPKSVLDIGCGEGYYTSAMQGC-TDQCVGVD 112
Cdd:pfam08003 105 DRVLPHLSPLKGRTILDVGCGNGYHMWRMLGEgAAMVVGID 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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