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Conserved domains on  [gi|491314772|ref|WP_005172750|]
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MULTISPECIES: acetate/propionate family kinase [Acinetobacter]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.-
Gene Ontology:  GO:0016774|GO:0016310|GO:0000287|GO:0005524|GO:0006082|GO:0016301
PubMed:  7883769|23031654|16678422|9484901

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-388 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 580.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   5 VLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANY-------R 76
Cdd:COG0282    3 ILVLNAGSSSLKFQLFdMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHgiikdldE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  77 PDAIGHRVVHGGS-LTKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAYRYAL 155
Cdd:COG0282   83 IDAVGHRVVHGGEkFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 156 PKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGTRSGD 234
Cdd:COG0282  163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGkPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 235 VDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGLPRID 314
Cdd:COG0282  243 IDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491314772 315 GLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNdlKRGTEGRIDSGTGP-QIWVVPTDEEGRIAQEVHSVVE 388
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-388 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 580.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   5 VLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANY-------R 76
Cdd:COG0282    3 ILVLNAGSSSLKFQLFdMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHgiikdldE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  77 PDAIGHRVVHGGS-LTKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAYRYAL 155
Cdd:COG0282   83 IDAVGHRVVHGGEkFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 156 PKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGTRSGD 234
Cdd:COG0282  163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGkPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 235 VDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGLPRID 314
Cdd:COG0282  243 IDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491314772 315 GLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNdlKRGTEGRIDSGTGP-QIWVVPTDEEGRIAQEVHSVVE 388
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-388 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 562.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   3 KSVLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANYRP---- 77
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIdMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLglik 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  78 -----DAIGHRVVHGGSL-TKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAY 151
Cdd:PRK00180  81 dldeiTAVGHRVVHGGEKfTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 152 RYALPKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGT 230
Cdd:PRK00180 161 LYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGkPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 231 RSGDVDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGL 310
Cdd:PRK00180 241 RSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAAL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 311 -PRIDGLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNDLKRGTEGRIDSGTGP-QIWVVPTDEEGRIAQEVHSVVE 388
Cdd:PRK00180 321 nGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSKvKVLVIPTNEELMIARDTLRLLG 400
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-383 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 525.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   5 VLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANY-------R 76
Cdd:cd24010    1 ILVINCGSSSLKFQLFdMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPelgvsldE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  77 PDAIGHRVVHGG-SLTKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAYRYAL 155
Cdd:cd24010   81 IDAVGHRVVHGGeKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 156 PKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGTRSGD 234
Cdd:cd24010  161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGkPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 235 VDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGLPRID 314
Cdd:cd24010  241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 315 GLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNdLKRGTEGRIDSGTGP-QIWVVPTDEEGRIAQEV 383
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNK-AAGGGEREISTPDSKvKVLVIPTNEELMIARDT 389
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 5-381 1.86e-152

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 436.08  E-value: 1.86e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772    5 VLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANYRP------ 77
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFdAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIiellae 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   78 -DAIGHRVVHGGSL-TKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAYRYAL 155
Cdd:pfam00871  82 iTLIGHRVVHGGEKfTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  156 PKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGTRSGD 234
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNkPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  235 VDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGLPRID 314
Cdd:pfam00871 242 IDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERLD 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491314772  315 GLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNdlKRGTEGRIDS-GTGPQIWVVPTDEEGRIAQ 381
Cdd:pfam00871 322 AIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNN--RFGKSGVISTeDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-383 7.06e-152

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 435.31  E-value: 7.06e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772    1 MSKSVLVINCGSSSIKFALL--LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANYRP- 77
Cdd:TIGR00016   2 SSMKILVLNAGSSSLKFALFdaVNGEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIi 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   78 ------DAIGHRVVHGGS-LTKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDL--PQIAVFDTAFHQSMPA 148
Cdd:TIGR00016  82 kllseiDLIGHRVVHGGEkFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPLPkaKNVAVFDTAFHQTMPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  149 HAYRYALPKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIV 227
Cdd:TIGR00016 162 EAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNkPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLM 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  228 MGTRSGDVDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALS 307
Cdd:TIGR00016 242 MGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYI 321

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491314772  308 CGL-PRIDGLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNDLKRGTEGRIDSGTGP-QIWVVPTDEEGRIAQEV 383
Cdd:TIGR00016 322 ASLeGNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESKvKILVIPTNEELMIAQDA 399
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-388 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 580.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   5 VLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANY-------R 76
Cdd:COG0282    3 ILVLNAGSSSLKFQLFdMDSEEVLAKGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHgiikdldE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  77 PDAIGHRVVHGGS-LTKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAYRYAL 155
Cdd:COG0282   83 IDAVGHRVVHGGEkFSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 156 PKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGTRSGD 234
Cdd:COG0282  163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGkPLADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 235 VDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGLPRID 314
Cdd:COG0282  243 IDPGVVLYLMRKEGLSADEVDDLLNKESGLLGLSGISSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491314772 315 GLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNdlKRGTEGRIDSGTGP-QIWVVPTDEEGRIAQEVHSVVE 388
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 3-388 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 562.04  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   3 KSVLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANYRP---- 77
Cdd:PRK00180   1 MKILVLNAGSSSLKFQLIdMPNEEVLASGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLglik 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  78 -----DAIGHRVVHGGSL-TKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAY 151
Cdd:PRK00180  81 dldeiTAVGHRVVHGGEKfTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 152 RYALPKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGT 230
Cdd:PRK00180 161 LYALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGkPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGT 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 231 RSGDVDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGL 310
Cdd:PRK00180 241 RSGDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAAL 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 311 -PRIDGLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNDLKRGTEGRIDSGTGP-QIWVVPTDEEGRIAQEVHSVVE 388
Cdd:PRK00180 321 nGRLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDISTPDSKvKVLVIPTNEELMIARDTLRLLG 400
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-383 0e+00

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 525.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   5 VLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANY-------R 76
Cdd:cd24010    1 ILVINCGSSSLKFQLFdMPTEEVLASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPelgvsldE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  77 PDAIGHRVVHGG-SLTKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAYRYAL 155
Cdd:cd24010   81 IDAVGHRVVHGGeKFTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 156 PKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGTRSGD 234
Cdd:cd24010  161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGkPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 235 VDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGLPRID 314
Cdd:cd24010  241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 315 GLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNdLKRGTEGRIDSGTGP-QIWVVPTDEEGRIAQEV 383
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNK-AAGGGEREISTPDSKvKVLVIPTNEELMIARDT 389
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 5-381 1.86e-152

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 436.08  E-value: 1.86e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772    5 VLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANYRP------ 77
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFdAVIGEVLLSGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIiellae 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   78 -DAIGHRVVHGGSL-TKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAYRYAL 155
Cdd:pfam00871  82 iTLIGHRVVHGGEKfTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  156 PKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGTRSGD 234
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNkPLEDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  235 VDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGLPRID 314
Cdd:pfam00871 242 IDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERLD 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491314772  315 GLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNdlKRGTEGRIDS-GTGPQIWVVPTDEEGRIAQ 381
Cdd:pfam00871 322 AIVFTGGIGENAAMVRELVLNALEVLGFEIDPERNN--RFGKSGVISTeDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 1-383 7.06e-152

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 435.31  E-value: 7.06e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772    1 MSKSVLVINCGSSSIKFALL--LEEQNFRIHGLAENLGTENARIKGVTVGNEPVDIHIPFADHKKALEVGLERLANYRP- 77
Cdd:TIGR00016   2 SSMKILVLNAGSSSLKFALFdaVNGEEVLASGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIi 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   78 ------DAIGHRVVHGGS-LTKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDL--PQIAVFDTAFHQSMPA 148
Cdd:TIGR00016  82 kllseiDLIGHRVVHGGEkFTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPLPkaKNVAVFDTAFHQTMPE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  149 HAYRYALPKFLYTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIV 227
Cdd:TIGR00016 162 EAYLYALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNkPLDDLNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLM 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  228 MGTRSGDVDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALS 307
Cdd:TIGR00016 242 MGTRSGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYI 321

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491314772  308 CGL-PRIDGLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNDLKRGTEGRIDSGTGP-QIWVVPTDEEGRIAQEV 383
Cdd:TIGR00016 322 ASLeGNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESKvKILVIPTNEELMIAQDA 399
PRK12379 PRK12379
propionate kinase;
5-382 4.53e-145

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 417.99  E-value: 4.53e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   5 VLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIkgvTV-GNEPVDI-HIPFADHKKALEVGLE-RLANYRPDAI 80
Cdd:PRK12379   7 VLVINCGSSSIKFSVLdASDCEVLMSGIADGINSENAFL---SVnGGEPAPLaHHSYEGALKAIAFELEkRNLNDSVALI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  81 GHRVVHGGSL-TKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAYRYALPKFL 159
Cdd:PRK12379  84 GHRIAHGGSIfTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYLYGLPWEY 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 160 YTAHGVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGTRSGDVDPS 238
Cdd:PRK12379 164 YEELGVRRYGFHGTSHRYVSQRAHSLLNlDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVDFG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 239 LHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGLPRIDGLFF 318
Cdd:PRK12379 244 AMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAASLHRLDGIIF 323

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491314772 319 TGGIGENSAYIREKTMTYLPHFGFNLDKSANNDLKRGTEGRIDSGTGPQIW-VVPTDEEGRIAQE 382
Cdd:PRK12379 324 TGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQPNSGGERIISSENSRVICaVIPTNEEKMIALD 388
PRK12440 PRK12440
acetate/propionate family kinase;
1-382 7.16e-121

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 356.48  E-value: 7.16e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   1 MSKS-VLVINCGSSSIKFALLLEEQ-NFRIHGLAENLGTENARIKGVTVGnEPVDIHIPFAD--HKKALE--VGLERLAN 74
Cdd:PRK12440   1 MSNSyVLVINSGSSSLKFAVIDSVTgEAVLSGLGECFGLEDARMSWKYQG-EKTEIAIEGEDnhHKIAIGrlVGLTEELG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  75 YRPD--AIGHRVVHGG-SLTKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAY 151
Cdd:PRK12440  80 FTQDivAVGHRIVHGGeKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAF 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 152 RYALPKFLYTAHGVRRYGFHGTSHAYVSDRGSELAGS-LKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGT 230
Cdd:PRK12440 160 TGAIAKELYTDFGIRRYGFHGTSHYFVSREAAKMLNKpIEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 231 RSGDVDPSLHSFLAKNlGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGL 310
Cdd:PRK12440 240 RCGDLDPGIIEFLLKK-GWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLAAL 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491314772 311 PRIDGLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNDLKRGTEGRIDSGT--GPQIWVVPTDEEGRIAQE 382
Cdd:PRK12440 319 DSLDGIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARFGKAGIIAKSEllNAVAMVIPTNEEFVIAQQ 392
PRK07157 PRK07157
acetate kinase; Provisional
 1-388 7.18e-115

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 340.95  E-value: 7.18e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   1 MSKSVLVINCGSSSIKFALLlEEQNFRIH--GLAENLGTENARIKgVTVGNEPVDIHIPFADHKKALEVGLE-----RLA 73
Cdd:PRK07157   1 MKAKILVINAGSSSIKWQLF-DKENLNLIasGLAERIGLENGLIK-IKFGKKKYEKEVDMPNHKVAVAVLIEiweenKLI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  74 NYRPD--AIGHRVVHGG-SLTKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHA 150
Cdd:PRK07157  79 EDLEEieLIGFRVVHGGdYFNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKIN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 151 YRYALPKFLYTAHGVRRYGFHGTSHAYVSDRGSELAGSlKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGT 230
Cdd:PRK07157 159 YTYPINYEIAKKYGIKKYGFHGISHKFITNKVEKILNK-DKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 231 RSGDVDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGL 310
Cdd:PRK07157 238 RSGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKI 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 311 -PRIDGLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNDlKRGTEGRIDSGTGPQ----IWVVPTDEEGRIAQEVHS 385
Cdd:PRK07157 318 gKKIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKNLK-KIGEYGPIELISTPDsdipVYVIRTNEELLIAKNAIK 396


                 ...
gi 491314772 386 VVE 388
Cdd:PRK07157 397 LYE 399
PRK12397 PRK12397
acetate/propionate family kinase;
1-383 2.15e-110

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 329.88  E-value: 2.15e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   1 MSKSVLVINCGSSSIKFALL-LEEQNFRIHGLAENLGTENARIKgVTVGNEPVDIHIPFADHKKALEVGLERLANYRP-- 77
Cdd:PRK12397   1 MSYKIMAINAGSSSLKFQLLeMPQGDMLCQGLIERIGMADAQVT-IKTHSQKWQETVPVADHRDAVTLLLEKLLGYQIin 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  78 -----DAIGHRVVHGGSLTK-AELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVFDTAFHQSMPAHAY 151
Cdd:PRK12397  80 slrdiDGVGHRVAHGGEFFKdSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 152 RYALPKFLYTAHGVRRYGFHGTSHAYVSDRGSELAGS-LKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLTPLEGIVMGT 230
Cdd:PRK12397 160 IYPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVpLSALRVICCHLGNGSSICAIKNGRSVNTSMGFTPQSGVMMGT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 231 RSGDVDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGL 310
Cdd:PRK12397 240 RSGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGSYIMQM 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491314772 311 PRIDGLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNDlkrgTEGRIDSGTGP-QIWVVPTDEEGRIAQEV 383
Cdd:PRK12397 320 GGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQR----NATFIQTENALvKVAVINTNEELMIAQDV 389
PRK07058 PRK07058
acetate/propionate family kinase;
1-386 3.69e-89

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 275.00  E-value: 3.69e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   1 MSKSVLV-INCGSSSIKFALlleeqnFRIHGlaenlgTENARI-KGV------------TVGNEPVDIHI---PFADHKK 63
Cdd:PRK07058   1 MSKPLLLtFNAGSSTVKIGL------FEVDG------NEARRIgKGDidfrraplrfhlRNGGETLDIPLkasVTDDLHT 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  64 ALEVGLERLANY----RPDAIGHRVVHGG-SLTKAELINDEIIEKIREATPLAPLHNPAHLIGIEATKRLFPDLPQIAVF 138
Cdd:PRK07058  69 VLDETFDWLAAHfdvsELVAVGHRVVHGGdRFAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASF 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 139 DTAFHQSMPAHAYRYALPKFLYtAHGVRRYGFHGTSHAYVSDRGSELAGSLKQGGWLTAHLGNGSSTCAVWNGKSVDTSM 218
Cdd:PRK07058 149 DTAFHRTQPDLVRRFAIPRALH-DEGIKRYGFHGLSYKFVAGELRRRAPELARGKVVAAHLGSGASLCALDAGKSRDTSM 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 219 GLTPLEGIVMGTRSGDVDPSLHSFLAKNLGWDIYKIDKMLNSQSGLLGLSDLSNDMRTLIEASEQGnedAALAIEVFCYR 298
Cdd:PRK07058 228 GFSTLDGIPMATRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDLLASDAPE---AREALDLFALR 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 299 LAKSLAALSCGLPRIDGLFFTGGIGENSAYIREKTMTYLPHFGFNLDKSANNdlkrGTEGRIDSGTGP-QIWVVPTDEEG 377
Cdd:PRK07058 305 IAGEIARLAATLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANA----ANAFTISSRTSRvAAFVIPTDEEQ 380


                 ....*....
gi 491314772 378 RIAQEVHSV 386
Cdd:PRK07058 381 VIADEAFSV 389
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 5-332 1.14e-15

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 77.57  E-value: 1.14e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772   5 VLVINCGSSSIKFALLLEEQ---NFRIHGLAENLGTENARIKGVTVGNEPVDihipfaDHKKALEVGLERLanyrpDAIg 81
Cdd:cd24011    2 ILVINPGSTSTKIAVFEGEEevfEETIEHSPEELAKFPSIIDQLEFRKEAVL------DFLKENGIDLSDL-----DAI- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772  82 hrVVHGGSLTKAE----LINDEIIEKIREAT----------PLAplHNPAHLIGIEATkrlfpdlpqiaVFDTAFHQSMP 147
Cdd:cd24011   70 --VGRGGLLKPIPggtyRVNEAMLEDLLSGPlgehasnlgaPIA--YELAKEYGIPAY-----------IVDPVVVDEMD 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 148 AHAYRYALPKFlytahgVRRYGFHGTSHAYVSDRGSELAG-SLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLtPLEGI 226
Cdd:cd24011  135 PVARITGIPEI------ERRSIFHALNQKAVARRAAKELGkPYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGP 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 227 VMGTRSGDVDPS--LHSFLAKNLGWDiyKIDKMLNSQSGLLGLSDlSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLA 304
Cdd:cd24011  208 FSPERAGTLPVGdlIKLCFSGKYTLE--ELKKKLKGKGGLVAYLG-TNDFREVEKRIEAGDEKAKLVLDAMAYQIAKEIG 284

                        330       340
                 ....*....|....*....|....*....
gi 491314772 305 ALSCGLP-RIDGLFFTGGIGeNSAYIREK 332
Cdd:cd24011  285 ALAAVLKgKVDAIILTGGLA-YSKRLVDR 312
PRK03011 PRK03011
butyrate kinase; Provisional
 166-322 2.58e-10

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 61.33  E-value: 2.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 166 RRYGFHGTSHAYVSDR-GSELAGSLKQGGWLTAHLGNGSSTCAVWNGKSVDTSMGLtPLEGIVMGTRSGDVdPSLHsfLA 244
Cdd:PRK03011 149 RKSIFHALNQKAVARRvAKELGKKYEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGGL-PVGD--LV 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491314772 245 KNL--GWDIYK-IDKMLNSQSGLLGLSDlSNDMRTLIEASEQGNEDAALAIEVFCYRLAKSLAALSCGLP-RIDGLFFTG 320
Cdd:PRK03011 225 ELCfsGKYTKEeLKKKLVGKGGLVAYLG-TNDAREVEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKgKVDAIVLTG 303


                 ..
gi 491314772 321 GI 322
Cdd:PRK03011 304 GL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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