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Conserved domains on  [gi|491317566|ref|WP_005175534|]
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MULTISPECIES: type II toxin-antitoxin system RelE/ParE family toxin [Pseudomonadota]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007661)

type II toxin-antitoxin system RelE/ParE family toxin similar to Haemophilus influenzae protein HI_1419

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3657 COG3657
Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];
1-98 2.10e-47

Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];


:

Pssm-ID: 442874  Cd Length: 103  Bit Score: 146.45  E-value: 2.10e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491317566   1 MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGDKS 80
Cdd:COG3657    3 YYTIDGTEPFDEWLASLKDRRARARILARLDRLELGNFGDVKPVGEGVSELRIDFGPGYRVYYAQRGDVLVLLLCGGDKS 82

                         90
                 ....*....|....*...
gi 491317566  81 TQQQDIDRAVKLSKTLED 98
Cdd:COG3657   83 TQQKDIKKAKELAKEYKE 100
 
Name Accession Description Interval E-value
COG3657 COG3657
Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];
1-98 2.10e-47

Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];


Pssm-ID: 442874  Cd Length: 103  Bit Score: 146.45  E-value: 2.10e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491317566   1 MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGDKS 80
Cdd:COG3657    3 YYTIDGTEPFDEWLASLKDRRARARILARLDRLELGNFGDVKPVGEGVSELRIDFGPGYRVYYAQRGDVLVLLLCGGDKS 82

                         90
                 ....*....|....*...
gi 491317566  81 TQQQDIDRAVKLSKTLED 98
Cdd:COG3657   83 TQQKDIKKAKELAKEYKE 100
upstrm_HI1419 TIGR02683
putative addiction module killer protein; Members of this strictly bacterial protein family ...
 2-96 1.11e-42

putative addiction module killer protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the upstream member of a gene pair, where the downstream member is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, often are located with prophage regions, but also in both integrated plasmid regions and near housekeeping genes. Analysis suggests that the gene pair may serve as an addiction module.


Pssm-ID: 162974  Cd Length: 95  Bit Score: 134.25  E-value: 1.11e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491317566   2 IEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGDKST 81
Cdd:TIGR02683  1 YTIDRTDTFDKWLDGLKDPRAKARILARIDRLALGNFGDVKPVGEGVSELRIDFGPGYRVYFTQRGKVIILLLCGGDKST 80

                         90
                 ....*....|....*
gi 491317566  82 QQQDIDRAVKLSKTL 96
Cdd:TIGR02683 81 QQKDIKRAKELAKDL 95
Gp49 pfam05973
Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial ...
 12-94 1.76e-07

Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.


Pssm-ID: 461791  Cd Length: 90  Bit Score: 44.88  E-value: 1.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491317566  12 EWLDGIKDNmTRIRLNRRLDKVQRGNWGDIKP----LQDGVWEMREFFGAG-WR-MYYIQHGDVVIVmLGGGDKSTQQ-- 83
Cdd:pfam05973  1 DELDALPDK-VRAKFLAALDLLEEGGPDLGKPlvkkLGGGLWELRVRDAGGiYRvLYAFDPGRAVYV-LHAFQKKTQKtp 78

                         90
                 ....*....|..
gi 491317566  84 -QDIDRAVKLSK 94
Cdd:pfam05973 79 kKEIDLAERRLK 90
 
Name Accession Description Interval E-value
COG3657 COG3657
Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];
1-98 2.10e-47

Putative component of the toxin-antitoxin plasmid stabilization module [Defense mechanisms];


Pssm-ID: 442874  Cd Length: 103  Bit Score: 146.45  E-value: 2.10e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491317566   1 MIEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGDKS 80
Cdd:COG3657    3 YYTIDGTEPFDEWLASLKDRRARARILARLDRLELGNFGDVKPVGEGVSELRIDFGPGYRVYYAQRGDVLVLLLCGGDKS 82

                         90
                 ....*....|....*...
gi 491317566  81 TQQQDIDRAVKLSKTLED 98
Cdd:COG3657   83 TQQKDIKKAKELAKEYKE 100
upstrm_HI1419 TIGR02683
putative addiction module killer protein; Members of this strictly bacterial protein family ...
 2-96 1.11e-42

putative addiction module killer protein; Members of this strictly bacterial protein family are small, at roughly 100 amino acids. The gene is almost invariably the upstream member of a gene pair, where the downstream member is a predicted DNA-binding protein from a clade within Pfam helix-turn-helix family pfam01381. These gene pairs, when found on the bacterial chromosome, often are located with prophage regions, but also in both integrated plasmid regions and near housekeeping genes. Analysis suggests that the gene pair may serve as an addiction module.


Pssm-ID: 162974  Cd Length: 95  Bit Score: 134.25  E-value: 1.11e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491317566   2 IEIKRLPEFDEWLDGIKDNMTRIRLNRRLDKVQRGNWGDIKPLQDGVWEMREFFGAGWRMYYIQHGDVVIVMLGGGDKST 81
Cdd:TIGR02683  1 YTIDRTDTFDKWLDGLKDPRAKARILARIDRLALGNFGDVKPVGEGVSELRIDFGPGYRVYFTQRGKVIILLLCGGDKST 80

                         90
                 ....*....|....*
gi 491317566  82 QQQDIDRAVKLSKTL 96
Cdd:TIGR02683 81 QQKDIKRAKELAKDL 95
COG4679 COG4679
Phage-related protein [Mobilome: prophages, transposons];
1-98 1.95e-08

Phage-related protein [Mobilome: prophages, transposons];


Pssm-ID: 443715  Cd Length: 113  Bit Score: 47.92  E-value: 1.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491317566   1 MIEIKRLPEFDEWLDGIKDNMtRIRLNRRLDKVQRGNWGD----IKPLQDGVWEMREFFGAGW-RMYYIQHGDVVIVMLG 75
Cdd:COG4679    5 VEFYGTKEPVLDFLLALPAKV-RAKIGRALDLLQEGGPDLgkplTKGLGDGLFELRIKGGSGIyRVLYFAKFGDAVVVLH 83

                         90       100
                 ....*....|....*....|....*.
gi 491317566  76 GGDKSTQ---QQDIDRAVKLSKTLED 98
Cdd:COG4679   84 GFQKKTQktpKKEIELARKRLKEYLE 109
Gp49 pfam05973
Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial ...
 12-94 1.76e-07

Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.


Pssm-ID: 461791  Cd Length: 90  Bit Score: 44.88  E-value: 1.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491317566  12 EWLDGIKDNmTRIRLNRRLDKVQRGNWGDIKP----LQDGVWEMREFFGAG-WR-MYYIQHGDVVIVmLGGGDKSTQQ-- 83
Cdd:pfam05973  1 DELDALPDK-VRAKFLAALDLLEEGGPDLGKPlvkkLGGGLWELRVRDAGGiYRvLYAFDPGRAVYV-LHAFQKKTQKtp 78

                         90
                 ....*....|..
gi 491317566  84 -QDIDRAVKLSK 94
Cdd:pfam05973 79 kKEIDLAERRLK 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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