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Conserved domains on  [gi|491374863|ref|WP_005232756|]
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MULTISPECIES: flagellar motor switch protein FliM [Enterococcus]

Protein Classification

flagellar motor switch protein FliM( domain architecture ID 11448996)

flagellar motor switch protein FliM is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring) located at the base of the basal body

CATH:  3.40.1550.10
Gene Ontology:  GO:0003774|GO:0006935|GO:0071973
PubMed:  19081534

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FliM COG1868
Flagellar motor switch protein FliM [Cell motility];
1-335 1.23e-116

Flagellar motor switch protein FliM [Cell motility];


:

Pssm-ID: 441473 [Multi-domain]  Cd Length: 326  Bit Score: 340.22  E-value: 1.23e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863   1 MDQVLTQQEIDLLLNAMSSGEIDQEIIEIEdKQAKVKAYDFRRPTKLSKEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSL 80
Cdd:COG1868    1 MSDVLSQEEIDALLSAVSSGEVDAEEKEEE-EEKKVKPYDFRRPDRFSKERLPTLEIIHERFARLLRTSLSNLLRRNVEI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  81 QLAAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIEMNPQLCMMLVELLCGGldvyqnkPIEMDFSEKKSFTDIETAI 160
Cdd:COG1868   80 SVASVEQLTYGEFIRSLPVPTSLNIFRLEPLRGSALLEIDPSLVFALVDRLLGG-------DGRPHAIEGREFTEIEQRI 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 161 LEEVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQNMSPNEPVVLVTFTIKIFEVKHFINLCIPYVFFEGIIDKLSFR 240
Cdd:COG1868  153 IERLLELLLEDLEEAWAPVYPLEPELERSETNPQFAQIVSPNEVVVVVTFEVEIGDRSGMINICIPYSTLEPIRDKLSSR 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 241 NWFDSNQpVNQDDSRELQKSLNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQED 320
Cdd:COG1868  233 FQSDRKE-RDERWRERLREELEEAEVELSAELGETEITLRELLNLKVGDVIPLDKKVDDPLTVYVGGVPKFEGKPGVSNG 311

                        330
                 ....*....|....*
gi 491374863 321 RLAIELLDKLEEEQE 335
Cdd:COG1868  312 RLAVKITEIIEEEEE 326
 
Name Accession Description Interval E-value
FliM COG1868
Flagellar motor switch protein FliM [Cell motility];
1-335 1.23e-116

Flagellar motor switch protein FliM [Cell motility];


Pssm-ID: 441473 [Multi-domain]  Cd Length: 326  Bit Score: 340.22  E-value: 1.23e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863   1 MDQVLTQQEIDLLLNAMSSGEIDQEIIEIEdKQAKVKAYDFRRPTKLSKEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSL 80
Cdd:COG1868    1 MSDVLSQEEIDALLSAVSSGEVDAEEKEEE-EEKKVKPYDFRRPDRFSKERLPTLEIIHERFARLLRTSLSNLLRRNVEI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  81 QLAAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIEMNPQLCMMLVELLCGGldvyqnkPIEMDFSEKKSFTDIETAI 160
Cdd:COG1868   80 SVASVEQLTYGEFIRSLPVPTSLNIFRLEPLRGSALLEIDPSLVFALVDRLLGG-------DGRPHAIEGREFTEIEQRI 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 161 LEEVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQNMSPNEPVVLVTFTIKIFEVKHFINLCIPYVFFEGIIDKLSFR 240
Cdd:COG1868  153 IERLLELLLEDLEEAWAPVYPLEPELERSETNPQFAQIVSPNEVVVVVTFEVEIGDRSGMINICIPYSTLEPIRDKLSSR 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 241 NWFDSNQpVNQDDSRELQKSLNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQED 320
Cdd:COG1868  233 FQSDRKE-RDERWRERLREELEEAEVELSAELGETEITLRELLNLKVGDVIPLDKKVDDPLTVYVGGVPKFEGKPGVSNG 311

                        330
                 ....*....|....*
gi 491374863 321 RLAIELLDKLEEEQE 335
Cdd:COG1868  312 RLAVKITEIIEEEEE 326
fliM PRK06666
flagellar motor switch protein FliM; Validated
 1-333 2.37e-89

flagellar motor switch protein FliM; Validated


Pssm-ID: 235849 [Multi-domain]  Cd Length: 337  Bit Score: 270.94  E-value: 2.37e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863   1 MDQVLTQQEIDLLLNAMSSGEIDQEIIEIEDKQAKVKAYDFRRPTKLSKEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSL 80
Cdd:PRK06666   2 MDDILSQEEIDALLSGVSDGEVDDEELKEEGDEKKVRPYDFKRQERFSRERLRSLEIINERFARLLRIGLSNLLRRSVEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  81 QLAAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIEMNPQLCMMLVELLCGGLDVYQNKpiemdfsEKKSFTDIETAI 160
Cdd:PRK06666  82 SVGSVDQQPYGEFIRSLPVPTSLNLVHMKPLRGTALIEFDPSLVFIMVDNLFGGDGRFHTK-------VGREFTETEQRI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 161 LEEVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQNMSPNEPVVLVTFTIKIFEVKHFINLCIPYVFFEGIIDKLSFR 240
Cdd:PRK06666 155 IDRILKLAFENLKEAWSSVVPIEPEYVRSEVNPQFANIVSPNEIVVVVSFHIEIGGGGGMMNICIPYSMIEPIREKLSSP 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 241 NWFDSNQPVNQDDSRELQKSLNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQED 320
Cdd:PRK06666 235 YWMSDSRDKDKRWRKELEQQVQQAEVELVAELGEIKLTLSEILNLKVGDVIPLEKPADDPLIVYVDGKPKFLCQYGKSNG 314

                        330
                 ....*....|...
gi 491374863 321 RLAIELLDKLEEE 333
Cdd:PRK06666 315 RKALQIEELIERE 327
fliM_switch TIGR01397
flagellar motor switch protein FliM; Members of this family are the flagellar motor switch ...
 3-331 1.85e-76

flagellar motor switch protein FliM; Members of this family are the flagellar motor switch protein FliM. The family excludes FliM homologs that lack an N-terminal region critical to interaction with phosphorylated CheY. One set lacking this N-terminal region is found in Rhizobium meliloti, in which the direction of flagellar rotation is not reversible (i.e. the FliM homolog does not act to reverse the motor direction), and in related species. Another is found in Buchnera, an obligate intracellular endosymbiont with genes for many of the components of the flagellar apparatus, but not, apparently, for flagellin iself. [Cellular processes, Chemotaxis and motility]


Pssm-ID: 130464 [Multi-domain]  Cd Length: 320  Bit Score: 237.60  E-value: 1.85e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863    3 QVLTQQEIDLLLNAMSSGEIDQEIIEIEDkQAKVKAYDFRRPTKLSKEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSLQL 82
Cdd:TIGR01397   1 DILSQDEIDALLGGLSEGDDSDEPSAVED-EKKVKPYDFKRPDRVSKEQLRTLEIINERFARLLRTSLSNMLRRFVEVSV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863   83 AAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIEMNPQLCMMLVELLCGGLDVYQNkpiemdfsEKKSFTDIETAILE 162
Cdd:TIGR01397  80 ASVDQLTYGEFLRSLPVPTSLNVFRMEPLRGTALIEIDPSLIYTMVDRLFGGQGRSVP--------EGREFTEIERRVID 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  163 EVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQNMSPNEPVVLVTFTIKIFEVKHFINLCIPYVFFEGIIDKLSFRnw 242
Cdd:TIGR01397 152 RILDRVLEDLKEAWSPVMPLEPELDRSETNPQFAQIVPPNEIVVLVSFSVEVGETEGMINICLPYSTLEPIRSKLSQR-- 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  243 FDSNQPVNQDDSR--ELQKSLNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQED 320
Cdd:TIGR01397 230 FMQSEKVERDSSWrdALERELSTVPVDMRAVLGEVEVSLRQLLNLQVGDVIPLNTDMPEEVSLRVGGRPKFRAQPGVRGG 309

                         330
                  ....*....|.
gi 491374863  321 RLAIELLDKLE 331
Cdd:TIGR01397 310 KLAVQITRVIE 320
FliM cd17908
flagellar protein FliM; This family contains bacterial flagellar protein FliM which is ...
 49-236 4.01e-61

flagellar protein FliM; This family contains bacterial flagellar protein FliM which is localized in the flagellar switch complex along with FliG and FliY; all are present in many copies, and together they correspond structurally to the C-ring of the flagellar basal body. FliM does not contain the CheC consensus sequence of the phosphatase active site ([DS]xxxExxNx(22)P) and is not a CheY-P phosphatase. FliM sits in the center of the rotor with the N-terminal region interacting with the signaling protein, phosphorylated CheY (CheY-P). The activated form of CheY destabilizes the parallel arrangement of FliM molecules, and perturbs FliG alignment in a process that may reflect the onset of rotation switching. This suggests a model of C-ring assembly in which intermolecular contacts among FliG domains provide a template for FliM assembly. Recent data show that binding of FliM to spermine synthase, SpeE, contributes to flagellar motility, an association that is unique to Helicobacter species.


Pssm-ID: 381736  Cd Length: 181  Bit Score: 193.12  E-value: 4.01e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  49 KEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSLQLAAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIEMNPQLCMMLV 128
Cdd:cd17908    1 REQLRTLEVIHERFARLLSTSLSALLRTPVEVSLESVEQLTYGEFLASLPNPTSLAVFSLEPLKGRALLEIDPSLVFALV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 129 ELLCGGldvyqnkPIEMDFSEKKSFTDIETAILEEVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQNMSPNEPVVLV 208
Cdd:cd17908   81 DRLLGG-------SGEAPKIEGREFTEIELRLLRRLLERLLEDLEEAWSPVLPLEFELERIETNPQFAQIAPPNEPVVVV 153

                        170       180
                 ....*....|....*....|....*...
gi 491374863 209 TFTIKIFEVKHFINLCIPYVFFEGIIDK 236
Cdd:cd17908  154 TFEVKIGEREGTINLCIPYSALEPILEK 181
FliM pfam02154
Flagellar motor switch protein FliM;
39-237 2.30e-46

Flagellar motor switch protein FliM;


Pssm-ID: 111086  Cd Length: 192  Bit Score: 155.61  E-value: 2.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863   39 YDFRRPTKLSKEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSLQLAAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIE 118
Cdd:pfam02154   1 YDFKRPDRVSKEQLRTLEIIHERFARLMTTSLSNLLRSMVEVSVASVDQMTYGEFIRSIPVPTILNVFRMKPLKGTGLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  119 MNPQLCMMLVELLCGGLDVYQNKpiemdfsEKKSFTDIETAILEEVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQN 198
Cdd:pfam02154  81 VDPSIAFIIVDRLFGGDGRFHAK-------EGREFTDIERRVIQRMLKRVLENYKEAWSPVVDLEPEYDRSEVNPQFAQI 153

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 491374863  199 MSPNEPVVLVTFTIKIFEVKHFINLCIPYVFFEGIIDKL 237
Cdd:pfam02154 154 VSPNEIVVLVSLEIEIGERGGMMNLCLPYITIEPIRSKL 192
 
Name Accession Description Interval E-value
FliM COG1868
Flagellar motor switch protein FliM [Cell motility];
1-335 1.23e-116

Flagellar motor switch protein FliM [Cell motility];


Pssm-ID: 441473 [Multi-domain]  Cd Length: 326  Bit Score: 340.22  E-value: 1.23e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863   1 MDQVLTQQEIDLLLNAMSSGEIDQEIIEIEdKQAKVKAYDFRRPTKLSKEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSL 80
Cdd:COG1868    1 MSDVLSQEEIDALLSAVSSGEVDAEEKEEE-EEKKVKPYDFRRPDRFSKERLPTLEIIHERFARLLRTSLSNLLRRNVEI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  81 QLAAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIEMNPQLCMMLVELLCGGldvyqnkPIEMDFSEKKSFTDIETAI 160
Cdd:COG1868   80 SVASVEQLTYGEFIRSLPVPTSLNIFRLEPLRGSALLEIDPSLVFALVDRLLGG-------DGRPHAIEGREFTEIEQRI 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 161 LEEVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQNMSPNEPVVLVTFTIKIFEVKHFINLCIPYVFFEGIIDKLSFR 240
Cdd:COG1868  153 IERLLELLLEDLEEAWAPVYPLEPELERSETNPQFAQIVSPNEVVVVVTFEVEIGDRSGMINICIPYSTLEPIRDKLSSR 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 241 NWFDSNQpVNQDDSRELQKSLNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQED 320
Cdd:COG1868  233 FQSDRKE-RDERWRERLREELEEAEVELSAELGETEITLRELLNLKVGDVIPLDKKVDDPLTVYVGGVPKFEGKPGVSNG 311

                        330
                 ....*....|....*
gi 491374863 321 RLAIELLDKLEEEQE 335
Cdd:COG1868  312 RLAVKITEIIEEEEE 326
fliM PRK06666
flagellar motor switch protein FliM; Validated
 1-333 2.37e-89

flagellar motor switch protein FliM; Validated


Pssm-ID: 235849 [Multi-domain]  Cd Length: 337  Bit Score: 270.94  E-value: 2.37e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863   1 MDQVLTQQEIDLLLNAMSSGEIDQEIIEIEDKQAKVKAYDFRRPTKLSKEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSL 80
Cdd:PRK06666   2 MDDILSQEEIDALLSGVSDGEVDDEELKEEGDEKKVRPYDFKRQERFSRERLRSLEIINERFARLLRIGLSNLLRRSVEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  81 QLAAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIEMNPQLCMMLVELLCGGLDVYQNKpiemdfsEKKSFTDIETAI 160
Cdd:PRK06666  82 SVGSVDQQPYGEFIRSLPVPTSLNLVHMKPLRGTALIEFDPSLVFIMVDNLFGGDGRFHTK-------VGREFTETEQRI 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 161 LEEVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQNMSPNEPVVLVTFTIKIFEVKHFINLCIPYVFFEGIIDKLSFR 240
Cdd:PRK06666 155 IDRILKLAFENLKEAWSSVVPIEPEYVRSEVNPQFANIVSPNEIVVVVSFHIEIGGGGGMMNICIPYSMIEPIREKLSSP 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 241 NWFDSNQPVNQDDSRELQKSLNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQED 320
Cdd:PRK06666 235 YWMSDSRDKDKRWRKELEQQVQQAEVELVAELGEIKLTLSEILNLKVGDVIPLEKPADDPLIVYVDGKPKFLCQYGKSNG 314

                        330
                 ....*....|...
gi 491374863 321 RLAIELLDKLEEE 333
Cdd:PRK06666 315 RKALQIEELIERE 327
fliM_switch TIGR01397
flagellar motor switch protein FliM; Members of this family are the flagellar motor switch ...
 3-331 1.85e-76

flagellar motor switch protein FliM; Members of this family are the flagellar motor switch protein FliM. The family excludes FliM homologs that lack an N-terminal region critical to interaction with phosphorylated CheY. One set lacking this N-terminal region is found in Rhizobium meliloti, in which the direction of flagellar rotation is not reversible (i.e. the FliM homolog does not act to reverse the motor direction), and in related species. Another is found in Buchnera, an obligate intracellular endosymbiont with genes for many of the components of the flagellar apparatus, but not, apparently, for flagellin iself. [Cellular processes, Chemotaxis and motility]


Pssm-ID: 130464 [Multi-domain]  Cd Length: 320  Bit Score: 237.60  E-value: 1.85e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863    3 QVLTQQEIDLLLNAMSSGEIDQEIIEIEDkQAKVKAYDFRRPTKLSKEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSLQL 82
Cdd:TIGR01397   1 DILSQDEIDALLGGLSEGDDSDEPSAVED-EKKVKPYDFKRPDRVSKEQLRTLEIINERFARLLRTSLSNMLRRFVEVSV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863   83 AAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIEMNPQLCMMLVELLCGGLDVYQNkpiemdfsEKKSFTDIETAILE 162
Cdd:TIGR01397  80 ASVDQLTYGEFLRSLPVPTSLNVFRMEPLRGTALIEIDPSLIYTMVDRLFGGQGRSVP--------EGREFTEIERRVID 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  163 EVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQNMSPNEPVVLVTFTIKIFEVKHFINLCIPYVFFEGIIDKLSFRnw 242
Cdd:TIGR01397 152 RILDRVLEDLKEAWSPVMPLEPELDRSETNPQFAQIVPPNEIVVLVSFSVEVGETEGMINICLPYSTLEPIRSKLSQR-- 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  243 FDSNQPVNQDDSR--ELQKSLNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQED 320
Cdd:TIGR01397 230 FMQSEKVERDSSWrdALERELSTVPVDMRAVLGEVEVSLRQLLNLQVGDVIPLNTDMPEEVSLRVGGRPKFRAQPGVRGG 309

                         330
                  ....*....|.
gi 491374863  321 RLAIELLDKLE 331
Cdd:TIGR01397 310 KLAVQITRVIE 320
FliM cd17908
flagellar protein FliM; This family contains bacterial flagellar protein FliM which is ...
 49-236 4.01e-61

flagellar protein FliM; This family contains bacterial flagellar protein FliM which is localized in the flagellar switch complex along with FliG and FliY; all are present in many copies, and together they correspond structurally to the C-ring of the flagellar basal body. FliM does not contain the CheC consensus sequence of the phosphatase active site ([DS]xxxExxNx(22)P) and is not a CheY-P phosphatase. FliM sits in the center of the rotor with the N-terminal region interacting with the signaling protein, phosphorylated CheY (CheY-P). The activated form of CheY destabilizes the parallel arrangement of FliM molecules, and perturbs FliG alignment in a process that may reflect the onset of rotation switching. This suggests a model of C-ring assembly in which intermolecular contacts among FliG domains provide a template for FliM assembly. Recent data show that binding of FliM to spermine synthase, SpeE, contributes to flagellar motility, an association that is unique to Helicobacter species.


Pssm-ID: 381736  Cd Length: 181  Bit Score: 193.12  E-value: 4.01e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  49 KEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSLQLAAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIEMNPQLCMMLV 128
Cdd:cd17908    1 REQLRTLEVIHERFARLLSTSLSALLRTPVEVSLESVEQLTYGEFLASLPNPTSLAVFSLEPLKGRALLEIDPSLVFALV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 129 ELLCGGldvyqnkPIEMDFSEKKSFTDIETAILEEVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQNMSPNEPVVLV 208
Cdd:cd17908   81 DRLLGG-------SGEAPKIEGREFTEIELRLLRRLLERLLEDLEEAWSPVLPLEFELERIETNPQFAQIAPPNEPVVVV 153

                        170       180
                 ....*....|....*....|....*...
gi 491374863 209 TFTIKIFEVKHFINLCIPYVFFEGIIDK 236
Cdd:cd17908  154 TFEVKIGEREGTINLCIPYSALEPILEK 181
FliM pfam02154
Flagellar motor switch protein FliM;
39-237 2.30e-46

Flagellar motor switch protein FliM;


Pssm-ID: 111086  Cd Length: 192  Bit Score: 155.61  E-value: 2.30e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863   39 YDFRRPTKLSKEYVNTLHMIFEDFSKMSSSMLSTQLRTNVSLQLAAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIE 118
Cdd:pfam02154   1 YDFKRPDRVSKEQLRTLEIIHERFARLMTTSLSNLLRSMVEVSVASVDQMTYGEFIRSIPVPTILNVFRMKPLKGTGLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  119 MNPQLCMMLVELLCGGLDVYQNKpiemdfsEKKSFTDIETAILEEVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQN 198
Cdd:pfam02154  81 VDPSIAFIIVDRLFGGDGRFHAK-------EGREFTDIERRVIQRMLKRVLENYKEAWSPVVDLEPEYDRSEVNPQFAQI 153

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 491374863  199 MSPNEPVVLVTFTIKIFEVKHFINLCIPYVFFEGIIDKL 237
Cdd:pfam02154 154 VSPNEIVVLVSLEIEIGERGGMMNLCLPYITIEPIRSKL 192
FliMN_C pfam01052
Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal ...
 266-331 1.08e-18

Type III flagellar switch regulator (C-ring) FliN C-term; This family includes the C-terminal region of flagellar motor switch proteins FliN and FliM. It is associated with family FliM, pfam02154 and family FliN_N pfam16973.


Pssm-ID: 460043 [Multi-domain]  Cd Length: 66  Bit Score: 78.92  E-value: 1.08e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491374863  266 LNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQEDRLAIELLDKLE 331
Cdd:pfam01052   1 VELSAELGRTTLTLRELLNLKVGDVIPLDKPADEPVDVLVNGKPKFRGELGVVGGNLAVRITEIID 66
fliM PRK12795
flagellar motor switch protein FliM; Reviewed
 2-335 1.70e-12

flagellar motor switch protein FliM; Reviewed


Pssm-ID: 237208 [Multi-domain]  Cd Length: 388  Bit Score: 67.78  E-value: 1.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863   2 DQVLTQQEIDLLL-NAMSSGEIDQEIIEIEDKQAKVKAYDfRRPTklskeyvntLHMIFEDFSKMsssmLSTQLRT---- 76
Cdd:PRK12795  55 ERVLNQDEIDSLLgFSLGEDSADDRSGIRAIIDSALVSYE-RLPM---------LEIVFDRLVRL----LTTSLRNftsd 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  77 NVSLQLAAIEQVSYDEFIHSIPKFTLLGLFHSQPLSGIQMIEMNPQLCMMLVELLCGGLDVYQNKPIemdfsEKKSFTDI 156
Cdd:PRK12795 121 NVEVSLDNITSVRFGDYLNSIPLPALLAVFKAEEWDNYGLLTVDSSLIYSIVDVLLGGRRGTAAMRI-----EGRPYTTI 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 157 ETAILEEVVAQFVRVYQNVWKDIVALDSVLDGIDTNPQLMQNMSPNEPVVLVTFTIKIFEVKHFINLCIPYVFFEGIIDK 236
Cdd:PRK12795 196 ERNLVERLVEVVLADLETAFRPLSPVTFTIDRLETNPRFAAIARPANAAILVRLRIDMEDRGGRIELLLPYATLEPIRDL 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 237 L--SFRnwfdsNQPVNQDDSRE--LQKSLNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFR 312
Cdd:PRK12795 276 LlqMFM-----GEKFGRDSIWEghLATEIWQTDVEVDAVLDEQTLPLKRVLNLKVGDTLMLDARPDALVTLRCGDVPLTE 350

                        330       340
                 ....*....|....*....|...
gi 491374863 313 AKPGKQEDRLAIELLDKLEEEQE 335
Cdd:PRK12795 351 GRMGRVGDRVAVRVEKPLRKPRT 373
FliN COG1886
Flagellar motor switch/type III secretory pathway protein FliN [Cell motility, Intracellular ...
 245-328 3.22e-10

Flagellar motor switch/type III secretory pathway protein FliN [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 441490 [Multi-domain]  Cd Length: 172  Bit Score: 58.48  E-value: 3.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 245 SNQPVNQDDSRELQkSLNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQEDRLAI 324
Cdd:COG1886   87 EDAPEAEEEPENLD-LLLDVPVEVTVELGRTRLTLRELLKLGPGSVIELDRLAGEPVDILVNGRLIARGEVVVVDDRFGV 165


                 ....
gi 491374863 325 ELLD 328
Cdd:COG1886  166 RITE 169
fliN TIGR02480
flagellar motor switch protein FliN; Proteins that consist largely of the domain described by ...
 264-328 1.17e-09

flagellar motor switch protein FliN; Proteins that consist largely of the domain described by this model for this protein family can be designated flagellar motor switch protein FliN. Longer proteins in which this region is a C-terminal domain typically are designated FliY. More distantly related sequences, outside the scope of this family, are associated with type III secretion and include the surface presentation of antigens protein SpaO required or invasion of host cells by Salmonella enterica. [Cellular processes, Chemotaxis and motility]


Pssm-ID: 131533 [Multi-domain]  Cd Length: 77  Bit Score: 54.14  E-value: 1.17e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491374863  264 VGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQEDRLAIELLD 328
Cdd:TIGR02480   8 IPVELTVELGRTRITLGDLLKLGEGSVIELDKLAGEPLDILVNGRLIARGEVVVVEDKFGIRITE 72
CheC_CheX_FliY cd16353
CheC/CheX/FliY (CXY) family phosphatases; The CXY family includes CheY-P-hydrolyzing proteins ...
 57-226 1.67e-08

CheC/CheX/FliY (CXY) family phosphatases; The CXY family includes CheY-P-hydrolyzing proteins that function in bacterial chemotaxis, which involves cellular processes that control the movement of organisms toward favorable environments via rotating flagella, which in turn determines the sense of rotation by the intracellular response regulator CheY. When phosphorylated, CheY-P interacts directly with the flagellar motor, and this signal is terminated by the CXY family of phosphatases (Escherichia coli uses CheZ). CheC acts as a weak CheY-P phosphatase but increases activity in the presence of CheD. Bacillus subtilis has only CheC and FliY while many systems also have CheX. CheC and CheX appear to be primarily involved in restoring normal CheY-P levels, whereas FliY seems to act on CheY-P constitutively. Unlike CheC and CheX, FliY is localized in the flagellar switch complex, which also contains the stator-coupling protein FliG and the target of CheY-P, FliM. CheC, CheX, and FliY phosphatases share a consensus sequence ([DS]xxxExxNx(22)P) with four conserved residues thought to form the phosphatase active site. CheC class I and FliY each have two active sites, while CheC class II and III, and CheX have only one. This family also includes FliM, a component of the flagellar switch complex and a target of CheY, which lacks the phosphatase active site consensus sequence, and is not a CheY phosphatase.


Pssm-ID: 381732 [Multi-domain]  Cd Length: 162  Bit Score: 53.27  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863  57 MIFEDFSKMSSSMLSTQLRTNVSLQLAAIEQVSYDEFIHSIPKFTLLGLF-HSQPLSGIQMIEMNPQLCMMLVELLCGGL 135
Cdd:cd16353    2 EIGNIFGGAAATTLSGRLRTGIEPEVGSPDQVKYEEVIRDVMIPSVVVVVgITGGIEGSAILEMRKDLAYKVLDI*MGGP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491374863 136 DVYQNKPIEmdfsekksftdIETAILEEVVAQFVRVYQNVWKDI-VALDSVLDGIDTNPQLMQNMSPNEPVVLVTFTIKI 214
Cdd:cd16353   82 GEPNRPLDE-----------IELSAVGEEGNNMLGLLAQALSDFgQTFDISPPNVEIGPQFVIIDNPEEIVLLVPFSVSW 150

                        170
                 ....*....|..
gi 491374863 215 FEVKHFINLCIP 226
Cdd:cd16353  151 EEFTSFFYVCWS 162
fliN PRK08983
flagellar motor switch protein FliN;
244-307 1.73e-03

flagellar motor switch protein FliN;


Pssm-ID: 236360 [Multi-domain]  Cd Length: 127  Bit Score: 37.81  E-value: 1.73e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491374863 244 DSNQPVNQDDSRELQKSLN-GVGLNLEVllGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDG 307
Cdd:PRK08983  32 DDSAPITEDEARKLDTILDiPVTISMEV--GRSFISIRNLLQLNQGSVVELDRVAGEPLDVMVNG 94
PRK06782 PRK06782
flagellar motor switch protein; Reviewed
 261-307 2.25e-03

flagellar motor switch protein; Reviewed


Pssm-ID: 235861 [Multi-domain]  Cd Length: 528  Bit Score: 39.82  E-value: 2.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 491374863 261 LNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDG 307
Cdd:PRK06782 459 LQDVPMNVKVVFGSTKKTIQDILSLQENEVVVLDEDIDEPIRIYVNG 505
PRK06033 PRK06033
flagellar motor switch protein FliN;
260-326 4.14e-03

flagellar motor switch protein FliN;


Pssm-ID: 180359 [Multi-domain]  Cd Length: 83  Bit Score: 35.89  E-value: 4.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491374863 260 SLNGVGLNLEVLLGHAQMSLSEFLHLEEGDVIKLDKKITEPLETFIDGKPYFRAKPGKQEDRLAIEL 326
Cdd:PRK06033   3 TLDAVSVELMVVLGRSSMPIHQVLRMGRGAVIPLDATEADEVWILANNHPIARGEVLIDRNRIAVEV 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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