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Conserved domains on  [gi|491425351|ref|WP_005283146|]
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MULTISPECIES: acetate/propionate family kinase [Acinetobacter]

Protein Classification

acetate/propionate family kinase( domain architecture ID 10000961)

acetate/propionate family kinase such as acetate kinase that catalyzes the production of acetyl-CoA by phosphorylating acetate in the presence of ATP; may act on propionate and/or other substrates as well

CATH:  3.30.420.40
EC:  2.7.2.-
Gene Ontology:  GO:0016774|GO:0016310|GO:0000287|GO:0005524|GO:0006082|GO:0016301
PubMed:  7883769|23031654|16678422|9484901

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-388 0e+00

Acetate kinase [Energy production and conversion];


:

Pssm-ID: 440051  Cd Length: 395  Bit Score: 551.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   5 VLVINCGSSSIKYALISERREDRIY-GLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANYHP------ 77
Cdd:COG0282    3 ILVLNAGSSSLKFQLFDMDSEEVLAkGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIikdlde 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  78 -QAIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRYAL 155
Cdd:COG0282   83 iDAVGHRVVHGGEKfSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 156 PKYLYTEHQVRRYGFHGTSHAYVTERASELAGNK-NQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRSGD 234
Cdd:COG0282  163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPlADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 235 VDPSLHLFLASNLGWDIQKIDSMLNKEsgllglsglsNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLPRLD 314
Cdd:COG0282  243 IDPGVVLYLMRKEGLSADEVDDLLNKEsgllglsgisSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491425351 315 GLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDalARGSEGRIDNGTGP-QIWVIPTDEEGRIAKETRQVIE 388
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-388 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 551.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   5 VLVINCGSSSIKYALISERREDRIY-GLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANYHP------ 77
Cdd:COG0282    3 ILVLNAGSSSLKFQLFDMDSEEVLAkGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIikdlde 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  78 -QAIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRYAL 155
Cdd:COG0282   83 iDAVGHRVVHGGEKfSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 156 PKYLYTEHQVRRYGFHGTSHAYVTERASELAGNK-NQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRSGD 234
Cdd:COG0282  163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPlADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 235 VDPSLHLFLASNLGWDIQKIDSMLNKEsgllglsglsNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLPRLD 314
Cdd:COG0282  243 IDPGVVLYLMRKEGLSADEVDDLLNKEsgllglsgisSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491425351 315 GLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDalARGSEGRIDNGTGP-QIWVIPTDEEGRIAKETRQVIE 388
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 5-388 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 540.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   5 VLVINCGSSSIKYALISERREDRIY-GLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANYHP------ 77
Cdd:PRK00180   3 ILVLNAGSSSLKFQLIDMPNEEVLAsGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLglikdl 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  78 ---QAIGHRVVHGG-NITKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRY 153
Cdd:PRK00180  83 deiTAVGHRVVHGGeKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 154 ALPKYLYTEHQVRRYGFHGTSHAYVTERASELAG-NKNQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRS 232
Cdd:PRK00180 163 ALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGkPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRS 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 233 GDVDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGL-P 311
Cdd:PRK00180 243 GDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491425351 312 RLDGLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDALARGSEGRI--DNGTgPQIWVIPTDEEGRIAKETRQVIE 388
Cdd:PRK00180 323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDIstPDSK-VKVLVIPTNEELMIARDTLRLLG 400
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-386 4.41e-180

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 505.89  E-value: 4.41e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   5 VLVINCGSSSIKYALISERREDR-IYGLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANY-------H 76
Cdd:cd24010    1 ILVINCGSSSLKFQLFDMPTEEVlASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPelgvsldE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  77 PQAIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRYAL 155
Cdd:cd24010   81 IDAVGHRVVHGGEKfTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 156 PKYLYTEHQVRRYGFHGTSHAYVTERASELAG-NKNQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRSGD 234
Cdd:cd24010  161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGkPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 235 VDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLPRLD 314
Cdd:cd24010  241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491425351 315 GLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDAlARGSEGRI-DNGTGPQIWVIPTDEEGRIAKETRQV 386
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKA-AGGGEREIsTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 5-381 5.15e-144

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 414.13  E-value: 5.15e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351    5 VLVINCGSSSIKYALISERREDRIY-GLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANYHP------ 77
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLsGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIiellae 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   78 -QAIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRYAL 155
Cdd:pfam00871  82 iTLIGHRVVHGGEKfTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  156 PKYLYTEHQVRRYGFHGTSHAYVTERASELAGNKN-QGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRSGD 234
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLeDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  235 VDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLPRLD 314
Cdd:pfam00871 242 IDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERLD 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491425351  315 GLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNdaLARGSEGRID-NGTGPQIWVIPTDEEGRIAK 381
Cdd:pfam00871 322 AIVFTGGIGENAAMVRELVLNALEVLGFEIDPERN--NRFGKSGVIStEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 5-383 2.00e-142

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 410.65  E-value: 2.00e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351    5 VLVINCGSSSIKYALISERREDRIY--GLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANYHP----- 77
Cdd:TIGR00016   6 ILVLNAGSSSLKFALFDAVNGEEVLasGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIiklls 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   78 --QAIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQL--PQVAVFDTAFHQTMPEHAYR 152
Cdd:TIGR00016  86 eiDLIGHRVVHGGEKfTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPLPkaKNVAVFDTAFHQTMPEEAYL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  153 YALPKYLYTEHQVRRYGFHGTSHAYVTERASELAGNKNQG-GWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTR 231
Cdd:TIGR00016 166 YALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDlNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMMGTR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  232 SGDVDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLP 311
Cdd:TIGR00016 246 SGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYIASLE 325

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491425351  312 -RLDGLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDALARGSEGRIDNGTGP-QIWVIPTDEEGRIAKET 383
Cdd:TIGR00016 326 gNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESKvKILVIPTNEELMIAQDA 399
 
Name Accession Description Interval E-value
AckA COG0282
Acetate kinase [Energy production and conversion];
5-388 0e+00

Acetate kinase [Energy production and conversion];


Pssm-ID: 440051  Cd Length: 395  Bit Score: 551.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   5 VLVINCGSSSIKYALISERREDRIY-GLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANYHP------ 77
Cdd:COG0282    3 ILVLNAGSSSLKFQLFDMDSEEVLAkGLVERIGLPGARLKHKDAGGEKVERELPIPDHAAALALVLELLTDHGIikdlde 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  78 -QAIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRYAL 155
Cdd:COG0282   83 iDAVGHRVVHGGEKfSESVLIDDEVLAAIEELIPLAPLHNPANLAGIEAARELLPDLPQVAVFDTAFHQTMPEVAYLYAL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 156 PKYLYTEHQVRRYGFHGTSHAYVTERASELAGNK-NQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRSGD 234
Cdd:COG0282  163 PYELYEKYGIRRYGFHGTSHRYVAERAAELLGKPlADLRLITAHLGNGASLCAIKNGKSVDTSMGFTPLEGLVMGTRSGD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 235 VDPSLHLFLASNLGWDIQKIDSMLNKEsgllglsglsNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLPRLD 314
Cdd:COG0282  243 IDPGVVLYLMRKEGLSADEVDDLLNKEsgllglsgisSDMRDLEEAAASGDERARLALDMFVYRIKKYIGAYAAALGGLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491425351 315 GLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDalARGSEGRIDNGTGP-QIWVIPTDEEGRIAKETRQVIE 388
Cdd:COG0282  323 ALVFTAGIGENSAEVRARVCEGLEFLGIELDPEANA--ARGGERVISTPDSRvKVLVIPTNEELMIARDTLRLLK 395
PRK00180 PRK00180
acetate kinase A/propionate kinase 2; Reviewed
 5-388 0e+00

acetate kinase A/propionate kinase 2; Reviewed


Pssm-ID: 234680  Cd Length: 402  Bit Score: 540.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   5 VLVINCGSSSIKYALISERREDRIY-GLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANYHP------ 77
Cdd:PRK00180   3 ILVLNAGSSSLKFQLIDMPNEEVLAsGLVERIGLPDSRIKIKVDGGEKEEEELPIPDHAEALKFLLNTLTDGKLglikdl 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  78 ---QAIGHRVVHGG-NITKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRY 153
Cdd:PRK00180  83 deiTAVGHRVVHGGeKFTESVLIDDEVLAAIEELSPLAPLHNPANLIGIEAARKLLPNVPQVAVFDTAFHQTMPEEAYLY 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 154 ALPKYLYTEHQVRRYGFHGTSHAYVTERASELAG-NKNQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRS 232
Cdd:PRK00180 163 ALPYELYEKYGIRRYGFHGTSHRYVSQRAAELLGkPLEELNLITCHLGNGASIAAIKNGKSVDTSMGFTPLEGLVMGTRS 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 233 GDVDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGL-P 311
Cdd:PRK00180 243 GDIDPAIIPYLMEKLGMSVDEIDNLLNKKSGLLGLSGVSSDMRDIEAAAEEGDERAKLALDVFVYRLAKYIGSYAAALnG 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491425351 312 RLDGLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDALARGSEGRI--DNGTgPQIWVIPTDEEGRIAKETRQVIE 388
Cdd:PRK00180 323 RLDAIVFTAGIGENSALVREKVLEGLEFLGIELDPEKNLAARFGKEGDIstPDSK-VKVLVIPTNEELMIARDTLRLLG 400
ASKHA_NBD_AcK_PK cd24010
nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain ...
 5-386 4.41e-180

nucleotide-binding domain (NBD) of the acetate kinase (AcK)/propionate kinase (PK) domain family; The family corresponds to a group of proteins which transfer phosphate from ATP to a short chain aliphatic acid. It includes acetate kinase (AckA) and propionate kinase (TdcD and PduW). Acetate kinase (EC 2.7.2.1), also called acetokinase, catalyzes the formation of acetyl phosphate from acetate and ATP. It can also catalyze the reverse reaction in the presence of a divalent cation. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically. Propionate kinase TdcD (EC 2.7.2.15) catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. It can also use acetyl phosphate as phosphate group acceptor. The family also includes propionate kinase PduW (EC 2.7.2.15) that works with phosphate acetyltransferase (pta) to capture exogenous propionate and regenerate propionyl-CoA during degradation of propionate and 1,2-propanediol (1,2-PD). This protein restores growth to an eutQ deletion on ethanolamine and tetrathionate under anoxic conditions. The AcK/PK family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466860  Cd Length: 392  Bit Score: 505.89  E-value: 4.41e-180
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   5 VLVINCGSSSIKYALISERREDR-IYGLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANY-------H 76
Cdd:cd24010    1 ILVINCGSSSLKFQLFDMPTEEVlASGLVERIGLEGARLKHKVNNGEKIKEELPIPDHEEALKAILDTLTDPelgvsldE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  77 PQAIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRYAL 155
Cdd:cd24010   81 IDAVGHRVVHGGEKfTESVLIDDEVIAAIEDLSPLAPLHNPANLAGIEAARKLLPDVPQVAVFDTAFHQTMPPHAYLYAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 156 PKYLYTEHQVRRYGFHGTSHAYVTERASELAG-NKNQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRSGD 234
Cdd:cd24010  161 PYELYEKYGIRRYGFHGTSHRYVSRRAAELLGkPLEDLNLITCHLGNGASICAIKNGKSVDTSMGLTPLEGLVMGTRSGD 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 235 VDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLPRLD 314
Cdd:cd24010  241 IDPAIVFYLMKKEGMSVDEIERLLNKKSGLLGISGVSSDMRDIEEAAEEGDERAKLALDVFVYRIKKYIGAYAAALGGVD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491425351 315 GLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDAlARGSEGRI-DNGTGPQIWVIPTDEEGRIAKETRQV 386
Cdd:cd24010  321 AIVFTGGIGENSALIRELVCEGLEFLGIELDEEKNKA-AGGGEREIsTPDSKVKVLVIPTNEELMIARDTVRL 392
Acetate_kinase pfam00871
Acetokinase family; This family includes acetate kinase, butyrate kinase and ...
 5-381 5.15e-144

Acetokinase family; This family includes acetate kinase, butyrate kinase and 2-methylpropanoate kinase.


Pssm-ID: 395700  Cd Length: 387  Bit Score: 414.13  E-value: 5.15e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351    5 VLVINCGSSSIKYALISERREDRIY-GLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANYHP------ 77
Cdd:pfam00871   2 VLVLNAGSSSIKFQLFDAVIGEVLLsGLAERIGLPNARILWKMNGGKKNAALLAGADHSEALNFILNTLLKHKIiellae 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   78 -QAIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRYAL 155
Cdd:pfam00871  82 iTLIGHRVVHGGEKfTESVLITDEVIQGIKDLIPLAPLHNPAHLDGIEEAFKLFPQVKNVAVFDTAFHQTMPEEAYLYAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  156 PKYLYTEHQVRRYGFHGTSHAYVTERASELAGNKN-QGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRSGD 234
Cdd:pfam00871 162 PYSWYKEHGIRRYGFHGTSHKYVSQRAAKILNKPLeDLNLITCHLGNGASVCAVRNGKSVDTSMGFTPLEGLVMGTRSGD 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  235 VDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLPRLD 314
Cdd:pfam00871 242 IDPAIIFYLAETLGMSADEINNTLNKKSGLLGLSGVSSDLRYVEDAYAEGKEDAQLAIKVYVHRLAKYIGSYAASLERLD 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491425351  315 GLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNdaLARGSEGRID-NGTGPQIWVIPTDEEGRIAK 381
Cdd:pfam00871 322 AIVFTGGIGENAAMVRELVLNALEVLGFEIDPERN--NRFGKSGVIStEDSRVKVVVIPTNEELMIAQ 387
ackA TIGR00016
acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in ...
 5-383 2.00e-142

acetate kinase; Acetate kinase is involved in the activation of acetate to acetyl CoA and in the secretion of acetate. It catalyzes the reaction ATP + acetate = ADP + acetyl phosphate. Some members of this family have been shown to act on propionate as well as acetate. An example of a propionate/acetate kinase is TdcD of E. coli (SP|P11868), an enzyme of an anaerobic pathway of threonine catabolism. It is not known how many members of this family act on additional substrates besides acetate. [Energy metabolism, Fermentation]


Pssm-ID: 272856  Cd Length: 404  Bit Score: 410.65  E-value: 2.00e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351    5 VLVINCGSSSIKYALISERREDRIY--GLAENLGAADARIKGVTLGGEPLELSIPYADHAKALETLLARLANYHP----- 77
Cdd:TIGR00016   6 ILVLNAGSSSLKFALFDAVNGEEVLasGLAERIFLPNARIKWVEDGGKKEAELLAGADHQEALKFILNTLLKDKIiklls 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   78 --QAIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQL--PQVAVFDTAFHQTMPEHAYR 152
Cdd:TIGR00016  86 eiDLIGHRVVHGGEKfTDSVIITDEVIQKIKDISPLAPLHNPAHLIGIEAALKLFPLPkaKNVAVFDTAFHQTMPEEAYL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  153 YALPKYLYTEHQVRRYGFHGTSHAYVTERASELAGNKNQG-GWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTR 231
Cdd:TIGR00016 166 YALPYSWYKEHGVRRYGFHGTSHKYVTQRAAKILNKPLDDlNLIVCHLGNGASVCAIKNGKSIDTSMGFTPLEGLMMGTR 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  232 SGDVDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLP 311
Cdd:TIGR00016 246 SGDIDPAIIFYLAETLGMSADDIENTLNKKSGLLGISGLSSDLRDIEDAYAEGNEQAKLAIKVYVHRIAKYIGSYIASLE 325

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491425351  312 -RLDGLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDALARGSEGRIDNGTGP-QIWVIPTDEEGRIAKET 383
Cdd:TIGR00016 326 gNLDAIVFTGGIGENAAMVRELVLEKLEVLGFELDPELNNAARSGKSGVISTPESKvKILVIPTNEELMIAQDA 399
PRK12379 PRK12379
propionate kinase;
5-380 4.85e-136

propionate kinase;


Pssm-ID: 183484  Cd Length: 396  Bit Score: 394.10  E-value: 4.85e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   5 VLVINCGSSSIKYALISERREDR-IYGLAENLGAADARIKgvTLGGEPLELSipYADHAKALETLLARLA----NYHPQA 79
Cdd:PRK12379   7 VLVINCGSSSIKFSVLDASDCEVlMSGIADGINSENAFLS--VNGGEPAPLA--HHSYEGALKAIAFELEkrnlNDSVAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  80 IGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRYALPKY 158
Cdd:PRK12379  83 IGHRIAHGGSIfTESVIITDEVIDNIRRVSPLAPLHNYANLSGIEAAQQLFPGVTQVAVFDTSFHQTLAPEAYLYGLPWE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 159 LYTEHQVRRYGFHGTSHAYVTERASELAG-NKNQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRSGDVDP 237
Cdd:PRK12379 163 YYEELGVRRYGFHGTSHRYVSQRAHSLLNlDEDDSGLVVAHLGNGASICAVRNGQSVDTSMGMTPLEGLMMGTRSGDVDF 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 238 SLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLPRLDGLV 317
Cdd:PRK12379 243 GAMAWIASQTGQTLGDLERVVNKESGLLGISGLSSDLRVLEKAWHEGHERAQLAIKTFVHRIARHIAGHAASLHRLDGII 322

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491425351 318 FTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDALARGSEGRIDNGTGPQIW-VIPTDEEGRIA 380
Cdd:PRK12379 323 FTGGIGENSSLIRRLVMEHLAVLGLEIDTEMNNQPNSGGERIISSENSRVICaVIPTNEEKMIA 386
PRK12440 PRK12440
acetate/propionate family kinase;
5-387 4.24e-115

acetate/propionate family kinase;


Pssm-ID: 183528  Cd Length: 397  Bit Score: 341.07  E-value: 4.24e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   5 VLVINCGSSSIKYALI-SERREDRIYGLAENLGAADARIkGVTLGGEPLELSIPYAD--HAKALETLLARLANYHPQ--- 78
Cdd:PRK12440   6 VLVINSGSSSLKFAVIdSVTGEAVLSGLGECFGLEDARM-SWKYQGEKTEIAIEGEDnhHKIAIGRLVGLTEELGFTqdi 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  79 -AIGHRVVHGG-NITKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAYRYALP 156
Cdd:PRK12440  85 vAVGHRIVHGGeKFTSTVRIDEEVTAEIESLSDLAPLHNPAGAIGIRAAMAAFPSLPQFAVFDTAFHQTMPKKAFTGAIA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 157 KYLYTEHQVRRYGFHGTSHAYVTERASELAgNK--NQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTRSGD 234
Cdd:PRK12440 165 KELYTDFGIRRYGFHGTSHYFVSREAAKML-NKpiEESSFISVHLGNGASVCAIKNGQSVDTSMGFTPLSGLMMGTRCGD 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 235 VDPSLHLFLASNlGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLPRLD 314
Cdd:PRK12440 244 LDPGIIEFLLKK-GWSQEKVFNSLNKKSGFLGVSGLTSDARGILEAMEEGHEGATLAFEVFTYRVAKYIASYLAALDSLD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491425351 315 GLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDALARGSEGRI--DNGTGPQIWVIPTDEEGRIAKETRQVI 387
Cdd:PRK12440 323 GIIFTGGIGENSLPIRREILKNLKLLGFVEDEKGNEDARFGKAGIIakSELLNAVAMVIPTNEEFVIAQQSVELL 397
PRK07157 PRK07157
acetate kinase; Provisional
 1-388 4.61e-103

acetate kinase; Provisional


Pssm-ID: 235948  Cd Length: 400  Bit Score: 310.52  E-value: 4.61e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   1 MAISVLVINCGSSSIKYALISERREDRIY-GLAENLGAADARIKgVTLGGEPLELSIPYADHAKALETLLARLANYHP-- 77
Cdd:PRK07157   1 MKAKILVINAGSSSIKWQLFDKENLNLIAsGLAERIGLENGLIK-IKFGKKKYEKEVDMPNHKVAVAVLIEIWEENKLie 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  78 -----QAIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAY 151
Cdd:PRK07157  80 dleeiELIGFRVVHGGDYfNGPTKLDDKEISKIEKVAKYAPLHNPGALQTIKAFKKVLPKAKLSASFDTAFHTSIPKINY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 152 RYALPKYLYTEHQVRRYGFHGTSHAYVTERASELAgNKNQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLEGVVMGTR 231
Cdd:PRK07157 160 TYPINYEIAKKYGIKKYGFHGISHKFITNKVEKIL-NKDKVNFVNLHIGNGASLCAIKNSKSIDTSMGLTPLAGVMMGTR 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 232 SGDVDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGL- 310
Cdd:PRK07157 239 SGDIDPSIHEFVAKEANMSISEFTDLLNKKSGLLGVSGISSDLRDVIKAAESGNKRAKFALDLYAQKIVDYLANYINKIg 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 311 PRLDGLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNdalargsEGRIDNGTGPQ----------IWVIPTDEEGRIA 380
Cdd:PRK07157 319 KKIDAIVFTAGVGENSAFVRELVINKINIPNIKLDKEKN-------LKKIGEYGPIElistpdsdipVYVIRTNEELLIA 391


                 ....*...
gi 491425351 381 KETRQVIE 388
Cdd:PRK07157 392 KNAIKLYE 399
PRK12397 PRK12397
acetate/propionate family kinase;
1-391 4.88e-103

acetate/propionate family kinase;


Pssm-ID: 183500  Cd Length: 404  Bit Score: 310.62  E-value: 4.88e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   1 MAISVLVINCGSSSIKYALISERREDRI-YGLAENLGAADARIKgVTLGGEPLELSIPYADHAKALETLLARLANYHP-- 77
Cdd:PRK12397   1 MSYKIMAINAGSSSLKFQLLEMPQGDMLcQGLIERIGMADAQVT-IKTHSQKWQETVPVADHRDAVTLLLEKLLGYQIin 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  78 -----QAIGHRVVHGGNITK-AELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQTMPEHAY 151
Cdd:PRK12397  80 slrdiDGVGHRVAHGGEFFKdSTLVTDETLAQIERLAELAPLHNPVNALGIHVFRQLLPDAPSVAVFDTAFHQTLDEPAY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 152 RYALPKYLYTEHQVRRYGFHGTSHAYVTERASELAGNKnqggwLSA------HLGNGSSTCAVWNGHSVDTSMGMTPLEG 225
Cdd:PRK12397 160 IYPLPWRYYAELGIRRYGFHGTSHKYVSGVLAEKLGVP-----LSAlrviccHLGNGSSICAIKNGRSVNTSMGFTPQSG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 226 VVMGTRSGDVDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSA 305
Cdd:PRK12397 235 VMMGTRSGDIDPSILPWIAQREGKTPQQLNQLLNNESGLLGVSGVSSDYRDVEQAANTGNRQAKLALTLFAERIRATIGS 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 306 LSCGLPRLDGLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDAlargSEGRIDNGTGP-QIWVIPTDEEGRIAKETR 384
Cdd:PRK12397 315 YIMQMGGLDALVFTGGIGENSARARSAVCHNLQFLGLAVDEEKNQR----NATFIQTENALvKVAVINTNEELMIAQDVM 390


                 ....*..
gi 491425351 385 QVIEPNA 391
Cdd:PRK12397 391 RIALPAT 397
PRK07058 PRK07058
acetate/propionate family kinase;
6-387 6.94e-78

acetate/propionate family kinase;


Pssm-ID: 235922  Cd Length: 396  Bit Score: 245.73  E-value: 6.94e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351   6 LVINCGSSSIKYaliserredriyGLAENLGAADARI-KGVT-LGGEPLELSI--------------PYADHAKALETLL 69
Cdd:PRK07058   7 LTFNAGSSTVKI------------GLFEVDGNEARRIgKGDIdFRRAPLRFHLrnggetldiplkasVTDDLHTVLDETF 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351  70 ARLANYHPQ----AIGHRVVHGGNI-TKAELLTPELVERIEAATPLAPLHNPAHLIGIEATMRLFPQLPQVAVFDTAFHQ 144
Cdd:PRK07058  75 DWLAAHFDVselvAVGHRVVHGGDRfAGAVLIDDATLDAIEALVPLAPLHQPQSLRLIRAIRHLRPHLPQTASFDTAFHR 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 145 TMPEHAYRYALPKYLYtEHQVRRYGFHGTSHAYVTERASELAGNKNQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMTPLE 224
Cdd:PRK07058 155 TQPDLVRRFAIPRALH-DEGIKRYGFHGLSYKFVAGELRRRAPELARGKVVAAHLGSGASLCALDAGKSRDTSMGFSTLD 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 225 GVVMGTRSGDVDPSLHLFLASNLGWDIQKIDSMLNKESGLLGLSGLSNDMRTLVeasENGHEDATLAIEVFCYRLAKSLS 304
Cdd:PRK07058 234 GIPMATRCGALDPGVVLHLLKQEGMSLDEVEDLLYHRSGLLGVSGISGDTRDLL---ASDAPEAREALDLFALRIAGEIA 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 305 ALSCGLPRLDGLVFTGGIGENSAYVREKTLGYLSHFGLQFSKEKNDALARgsegRIDNGTGP-QIWVIPTDEEGRIAKET 383
Cdd:PRK07058 311 RLAATLGGLDAVVFTAGIGEHQPAIRAAVCERLAWLGVELDPAANAANAF----TISSRTSRvAAFVIPTDEEQVIADEA 386


                 ....
gi 491425351 384 RQVI 387
Cdd:PRK07058 387 FSVL 390
ASKHA_NBD_BK cd24011
nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC ...
 166-355 5.90e-10

nucleotide-binding domain (NBD) of the butyrate kinase (BK) domain family; Butyrate kinase (EC 2.7.2.7) catalyzes the formation of butyryl-CoA by phosphorylating butyrate in the presence of ATP to form butyryl phosphate. Butyrate kinases exist in many fermentative species of the bacterial and archaeal families. They belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466861  Cd Length: 345  Bit Score: 60.24  E-value: 5.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 166 RRYGFHGTSHAYVTERASELAGNK-NQGGWLSAHLGNGSSTCAVWNGHSVDTSMGMtPLEGVVMGTRSGDVDPS--LHLF 242
Cdd:cd24011  147 RRSIFHALNQKAVARRAAKELGKPyEELNLIVAHLGGGISVGAHRKGRVIDVNNAL-DGEGPFSPERAGTLPVGdlIKLC 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491425351 243 LASNLGWDiqkidSMLNKESGL--LGLSGLSNDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLP-RLDGLVFT 319
Cdd:cd24011  226 FSGKYTLE-----ELKKKLKGKggLVAYLGTNDFREVEKRIEAGDEKAKLVLDAMAYQIAKEIGALAAVLKgKVDAIILT 300

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 491425351 320 GGIGeNSAYVREKTLGYLSHFG---LQFSKEKNDALARG 355
Cdd:cd24011  301 GGLA-YSKRLVDRIKERVGFIApviVYPGEFEMEALAEG 338
PRK03011 PRK03011
butyrate kinase; Provisional
 272-322 6.30e-05

butyrate kinase; Provisional


Pssm-ID: 235099  Cd Length: 358  Bit Score: 44.76  E-value: 6.30e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 491425351 272 NDMRTLVEASENGHEDATLAIEVFCYRLAKSLSALSCGLP-RLDGLVFTGGI 322
Cdd:PRK03011 254 NDAREVEKRIEEGDEKAKLVYEAMAYQIAKEIGAMAAVLKgKVDAIVLTGGL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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