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Conserved domains on  [gi|491446042|ref|WP_005303829|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Aeromonas]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-91 1.80e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 78.01  E-value: 1.80e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491446042  2 ELEEVAKALKELGHPTRLFIFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESRTLLCVSQYEVLE 81
Cdd:COG0640   6 ELEELAELFKALADPTRLRILRLLA---EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82

                        90
                ....*....|
gi 491446042 82 EIIAFFREEC 91
Cdd:COG0640  83 ELLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-91 1.80e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 78.01  E-value: 1.80e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491446042  2 ELEEVAKALKELGHPTRLFIFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESRTLLCVSQYEVLE 81
Cdd:COG0640   6 ELEELAELFKALADPTRLRILRLLA---EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82

                        90
                ....*....|
gi 491446042 82 EIIAFFREEC 91
Cdd:COG0640  83 ELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-84 1.73e-15

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 64.79  E-value: 1.73e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491446042  6 VAKALKELGHPTRLFIFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESRTLLCVSQYEVLEEII 84
Cdd:NF033788  1 LAELFKALADPTRLRILELLA---EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-69 3.75e-14

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 61.02  E-value: 3.75e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491446042   7 AKALKELGHPTRLFIFKHLVkaGEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESR 69
Cdd:pfam12840  1 DDVAEALADPTRLRILRALV--GDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-70 2.04e-12

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 57.31  E-value: 2.04e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491446042 10 LKELGHPTRLFIFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESRT 70
Cdd:cd00090   1 LKALSDPTRLRILRLLL---EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRR 58
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
21-70 2.17e-07

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 44.12  E-value: 2.17e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 491446042   21 IFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESRT 70
Cdd:smart00418  2 ILKLLA---EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKR 48
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
2-91 1.80e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 78.01  E-value: 1.80e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491446042  2 ELEEVAKALKELGHPTRLFIFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESRTLLCVSQYEVLE 81
Cdd:COG0640   6 ELEELAELFKALADPTRLRILRLLA---EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALA 82

                        90
                ....*....|
gi 491446042 82 EIIAFFREEC 91
Cdd:COG0640  83 ELLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-84 1.73e-15

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 64.79  E-value: 1.73e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491446042  6 VAKALKELGHPTRLFIFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESRTLLCVSQYEVLEEII 84
Cdd:NF033788  1 LAELFKALADPTRLRILELLA---EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-69 3.75e-14

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 61.02  E-value: 3.75e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491446042   7 AKALKELGHPTRLFIFKHLVkaGEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESR 69
Cdd:pfam12840  1 DDVAEALADPTRLRILRALV--GDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-70 2.04e-12

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 57.31  E-value: 2.04e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491446042 10 LKELGHPTRLFIFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESRT 70
Cdd:cd00090   1 LKALSDPTRLRILRLLL---EGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRR 58
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
1-88 2.20e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 54.97  E-value: 2.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491446042  1 MELEEVAKALKELGHPTRLFIFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRES----RTLLCvsq 76
Cdd:COG4189   4 LDDEESLEVLKALASETRLRILRLLA---EEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPgkrgRQKIC--- 77

                        90
                ....*....|..
gi 491446042 77 YEVLEEIIAFFR 88
Cdd:COG4189  78 YLRVDKILIVLP 89
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
21-70 2.17e-07

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 44.12  E-value: 2.17e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 491446042   21 IFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESRT 70
Cdd:smart00418  2 ILKLLA---EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKR 48
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
1-69 2.59e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 39.63  E-value: 2.59e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491446042   1 MELEEVAKALKELGHPTRLFIFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESR 69
Cdd:COG1777    2 SDDEDLDRLLDALGNPTRRRILALLS---EEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGR 67
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
5-63 1.18e-03

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 35.72  E-value: 1.18e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491446042   5 EVAKALKELG-HPTRLFIFKHLVKAGeqGLPVGELQKQLAIPASTLSHHIAALVSVGLVK 63
Cdd:COG1846   26 ALDRALAELGlTPAQFRVLAALAEAG--GLTQSELAERLGLTKSTVSRLLDRLEEKGLVE 83
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 15-62 2.26e-03

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 33.19  E-value: 2.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 491446042  15 HPTRLFIFKHLVkagEQGLPVGELQKQLAIPASTLSHHIAALVSVGLV 62
Cdd:pfam01022  1 DPTRLKILKLLA---EGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
4-70 2.72e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 34.85  E-value: 2.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491446042   4 EEVAKALKELGHPTRLFIFKHLVKAGeqGLPVGELQKQLAIPASTLSHHIAALVSVGLVKQNRESRT 70
Cdd:COG3398   85 EEEKKILAYLRRETPRRILLYLLENP--GATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRN 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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