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Conserved domains on  [gi|491527402|ref|WP_005385027|]
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MULTISPECIES: 1-acyl-sn-glycerol-3-phosphate acyltransferase [Vibrio]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 106732)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT super family cl17185
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 92-240 8.06e-08

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


The actual alignment was detected with superfamily member pfam01553:

Pssm-ID: 473073 [Multi-domain]  Cd Length: 131  Bit Score: 50.74  E-value: 8.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491527402   92 VTFSGLDKLDKNTSYLFVSNHRdIAMDPALVNYGLYQSgHRTVRIAIGDNLLKKPCATELMRLNKSFIVKRsaKAPREMM 171
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQ-SYLDVLLLSLALYKR-GRPLVFVAKKELFDIPLVGWLMRLLGCIFIDR--KNRKDAA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491527402  172 KALgqlsSYIKHSLDTGNSIWIAQKEGRAKDGNdftdpaiLKMFhvegrkqKISFGEYTRSLK--IVPVSI 240
Cdd:pfam01553  78 GTL----EYLVELLREGKLVVIFPEGTRSREGE-------LLPF-------KKGAFRLAIEAGvpIVPVAI 130
 
Name Accession Description Interval E-value
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 92-240 8.06e-08

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 50.74  E-value: 8.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491527402   92 VTFSGLDKLDKNTSYLFVSNHRdIAMDPALVNYGLYQSgHRTVRIAIGDNLLKKPCATELMRLNKSFIVKRsaKAPREMM 171
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQ-SYLDVLLLSLALYKR-GRPLVFVAKKELFDIPLVGWLMRLLGCIFIDR--KNRKDAA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491527402  172 KALgqlsSYIKHSLDTGNSIWIAQKEGRAKDGNdftdpaiLKMFhvegrkqKISFGEYTRSLK--IVPVSI 240
Cdd:pfam01553  78 GTL----EYLVELLREGKLVVIFPEGTRSREGE-------LLPF-------KKGAFRLAIEAGvpIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 92-193 1.35e-06

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 48.47  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491527402  92 VTFSGLDKLDKNTSYLFVSNHRdIAMDPALVNYGLyqsgHRTVRIAIGDNLLKKPCATELMRLNKSFIVKRSakAPREMM 171
Cdd:COG0204   31 VRVEGLENLPADGPVLIVANHQ-SWLDILLLLAAL----PRPVRFVAKKELFKIPLLGWLLRALGAIPVDRS--KRRAAL 103

                         90       100
                 ....*....|....*....|..
gi 491527402 172 KALGQLSSYIKHsldtGNSIWI 193
Cdd:COG0204  104 RALRQAVEALKA----GESLVI 121
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 91-193 1.97e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 47.65  E-value: 1.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491527402  91 GVTFSGLDKLDKNTSYLFVSNHRDIaMDPALVNYGLyqsgHRTVRIAIGDNLLKKPCATELMRLNKSFIVKRsaKAPREM 170
Cdd:cd07989   11 RVRVEGLENLPPKGPVIIVANHQSY-LDPLVLGAAL----PRPIRFVAKKELFKIPFLGWLLRLLGAIPIDR--GNGRSA 83

                         90       100
                 ....*....|....*....|...
gi 491527402 171 MKALGQlssyIKHSLDTGNSIWI 193
Cdd:cd07989   84 REALRE----AIEALKEGESVVI 102
 
Name Accession Description Interval E-value
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 92-240 8.06e-08

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 50.74  E-value: 8.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491527402   92 VTFSGLDKLDKNTSYLFVSNHRdIAMDPALVNYGLYQSgHRTVRIAIGDNLLKKPCATELMRLNKSFIVKRsaKAPREMM 171
Cdd:pfam01553   2 IEVHGLENLPRGGPAIVVANHQ-SYLDVLLLSLALYKR-GRPLVFVAKKELFDIPLVGWLMRLLGCIFIDR--KNRKDAA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491527402  172 KALgqlsSYIKHSLDTGNSIWIAQKEGRAKDGNdftdpaiLKMFhvegrkqKISFGEYTRSLK--IVPVSI 240
Cdd:pfam01553  78 GTL----EYLVELLREGKLVVIFPEGTRSREGE-------LLPF-------KKGAFRLAIEAGvpIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 92-193 1.35e-06

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 48.47  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491527402  92 VTFSGLDKLDKNTSYLFVSNHRdIAMDPALVNYGLyqsgHRTVRIAIGDNLLKKPCATELMRLNKSFIVKRSakAPREMM 171
Cdd:COG0204   31 VRVEGLENLPADGPVLIVANHQ-SWLDILLLLAAL----PRPVRFVAKKELFKIPLLGWLLRALGAIPVDRS--KRRAAL 103

                         90       100
                 ....*....|....*....|..
gi 491527402 172 KALGQLSSYIKHsldtGNSIWI 193
Cdd:COG0204  104 RALRQAVEALKA----GESLVI 121
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 91-193 1.97e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 47.65  E-value: 1.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491527402  91 GVTFSGLDKLDKNTSYLFVSNHRDIaMDPALVNYGLyqsgHRTVRIAIGDNLLKKPCATELMRLNKSFIVKRsaKAPREM 170
Cdd:cd07989   11 RVRVEGLENLPPKGPVIIVANHQSY-LDPLVLGAAL----PRPIRFVAKKELFKIPFLGWLLRLLGAIPIDR--GNGRSA 83

                         90       100
                 ....*....|....*....|...
gi 491527402 171 MKALGQlssyIKHSLDTGNSIWI 193
Cdd:cd07989   84 REALRE----AIEALKEGESVVI 102
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 95-245 1.24e-03

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 39.32  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491527402  95 SGLDKLDKNTSYLFVSNHRdIAMDPALVNYGLYQSGHRTVRIAIGDNLLKKpcaTELM-RLNKSFIVKRSAKAPREMMKa 173
Cdd:cd06551   17 KGPPPPPGGGPVLFVSNHS-SWWDGLILFLLLERGLRRDVYGLMDEELLER---YPFFtRLGAFSVDRDSPRSAAKSLK- 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491527402 174 lgqlssYIKHSL-DTGNSIWIAqKEGRAKDGNDFtdpAILKMFHVEGRKQKISFgeytrslKIVPVSIAYEND 245
Cdd:cd06551   92 ------YVARLLsKPGSVVWIF-PEGTRTRRDKR---PLQFKPGVAHLAEKAGV-------PIVPVALRYTFE 147
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
 92-292 1.34e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 39.48  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491527402  92 VTFSGLDKLDK----NTSYLFVSNHRDIaMDPALVNYGLYQSGHRTVRIAIGDNLLKkPCATELMRLNKSFIVKRSAKAP 167
Cdd:cd07993    6 VNEGQLERLRKaaqeGHPVVLLPTHRSY-LDFLLLSFILFSLGLPLPHIAAGENLNI-PILGTLLRRLGAFFIRRSFGKD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491527402 168 ReMMKALgqLSSYIKHSLDTGNSIWIAQKEGRAKDGNdFTDPA--ILKMFHVEGRKQKISfgeytrSLKIVPVSIAYEND 245
Cdd:cd07993   84 P-LYRAV--LQEYVQELLKNGQPLEFFIEGTRSRTGK-LLPPKlgLLSVVVEAYLKGSVP------DVLIVPVSISYDRV 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 491527402 246 PCDIAKAKELYEKaengryeKGEFEDIESIIQG--IVGYK-GRVHVAFGD 292
Cdd:cd07993  154 LEEELYAEELLGP-------PKPKESLSGLLGAskILRENfGRIRVDFGE 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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