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Conserved domains on  [gi|491560642|ref|WP_005418228|]
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MULTISPECIES: response regulator [Stenotrophomonas]

Protein Classification

response regulator( domain architecture ID 10066367)

response regulator receives the signal from a sensor partner in two-component systems through its receiver (REC) domain

CATH:  3.40.50.2300
Gene Ontology:  GO:0000160|GO:0000156
PubMed:  20226724
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AtoC super family cl34427
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 8-143 1.70e-25

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG2204:

Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 103.12  E-value: 1.70e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   8 ARPRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAH 87
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491560642  88 TADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL-------VNSPAGIFVAQAPAAVEL 143
Cdd:COG2204   81 TGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALerrrlrrENAEDSGLIGRSPAMQEV 143
Hpt pfam01627
Hpt domain; The histidine-containing phosphotransfer (HPt) domain is a novel protein module ...
 167-231 3.29e-05

Hpt domain; The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to contain a binding surface for Ssk1p (response regulator receiver domain containing protein pfam00072).


:

Pssm-ID: 426352 [Multi-domain]  Cd Length: 84  Bit Score: 41.18  E-value: 3.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491560642  167 LRELFLAELPGVRDAVEQAVDQHDERQLRSQLHRLQASCGFVGAARLGRAVRQLHHAPESGQAQA 231
Cdd:pfam01627   2 LLELFLEEAPELLEQLEQALDAEDLEALFRAAHTLKGSAGSLGLPALAELAHELEDLLREGELPL 66
 
Name Accession Description Interval E-value
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 8-143 1.70e-25

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 103.12  E-value: 1.70e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   8 ARPRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAH 87
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491560642  88 TADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL-------VNSPAGIFVAQAPAAVEL 143
Cdd:COG2204   81 TGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALerrrlrrENAEDSGLIGRSPAMQEV 143
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 13-111 5.21e-24

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 91.91  E-value: 5.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80

                         90
                 ....*....|....*....
gi 491560642  93 ASIHARLREAGFSDTLVKP 111
Cdd:cd00156   81 EEDAVRALELGADDYLVKP 99
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 13-122 9.94e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 83.74  E-value: 9.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHGD 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 491560642   93 ASIHARLREAGFSDTLVKPLGRDQLLKAVR 122
Cdd:pfam00072  82 EDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 26-227 2.38e-13

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 69.11  E-value: 2.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  26 KAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRS--HPDTPALAHTAdgdasiHA------ 97
Cdd:PRK11107 684 GALLEEQVEHVVLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIRACELIRQLphNQNTPIIAVTA------HAmagere 757

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  98 RLREAGFSDTLVKPLGRDQL----LKAVRRALVNSPAGIFVAQAPAAVELAVQDWDetaalAALNgQRNHLIAL-REL-- 170
Cdd:PRK11107 758 RLLSAGMDDYLAKPIDEAMLkqvlLRYKPGPKFTSRVVAPEPPEPVHFPNATLDWQ-----LALR-QAAGKPDLaRDMlq 831

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491560642 171 -FLAELPGVRDAVEQAVDQHDERQLRSQLHRLQASCGFVGAARLGRAVRQLHHAPESG 227
Cdd:PRK11107 832 mLLDFLPEVRNKVEEALAGEDPEGLLDLIHKLHGSCSYSGVPRLKKLCQLIEQQLRSG 889
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 10-64 8.43e-07

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 44.87  E-value: 8.43e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 491560642    10 PRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLP 64
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
Hpt pfam01627
Hpt domain; The histidine-containing phosphotransfer (HPt) domain is a novel protein module ...
 167-231 3.29e-05

Hpt domain; The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to contain a binding surface for Ssk1p (response regulator receiver domain containing protein pfam00072).


Pssm-ID: 426352 [Multi-domain]  Cd Length: 84  Bit Score: 41.18  E-value: 3.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491560642  167 LRELFLAELPGVRDAVEQAVDQHDERQLRSQLHRLQASCGFVGAARLGRAVRQLHHAPESGQAQA 231
Cdd:pfam01627   2 LLELFLEEAPELLEQLEQALDAEDLEALFRAAHTLKGSAGSLGLPALAELAHELEDLLREGELPL 66
 
Name Accession Description Interval E-value
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 8-143 1.70e-25

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 103.12  E-value: 1.70e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   8 ARPRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAH 87
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491560642  88 TADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL-------VNSPAGIFVAQAPAAVEL 143
Cdd:COG2204   81 TGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALerrrlrrENAEDSGLIGRSPAMQEV 143
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 5-125 1.88e-25

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 96.84  E-value: 1.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   5 PRAARPRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRR--SHPDT 82
Cdd:COG0784    1 PPLGGKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRAlpRLPDI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491560642  83 PALAHTADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:COG0784   81 PIIALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLL 123
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 13-111 5.21e-24

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 91.91  E-value: 5.21e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80

                         90
                 ....*....|....*....
gi 491560642  93 ASIHARLREAGFSDTLVKP 111
Cdd:cd00156   81 EEDAVRALELGADDYLVKP 99
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 9-201 6.97e-22

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 89.63  E-value: 6.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   9 RPRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHT 88
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  89 ADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRALvnspagifvaQAPAAVELAVQDW-DETAALAALNGQRNHL--- 164
Cdd:COG0745   81 ARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALL----------RRRAAEVLRVGDLlDLAAREVTRDGEPVELtpk 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 491560642 165 -IALRELFLAELPGV--RDAVEQAV---DQHDERQLRSQLHRL 201
Cdd:COG0745  151 eFRLLELLMRNPGRVvsREQLLEEVwgyDYGDDRTVDVHISRL 193
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 11-125 2.50e-21

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 86.18  E-value: 2.50e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLP--ADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHT 88
Cdd:COG4565    5 RVLIVEDDPMVAELLRRYLERLPgfEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVIT 84

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491560642  89 ADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:COG4565   85 AARDPETVREALRAGVVDYLIKPFTFERLREALERYL 121
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 13-122 9.94e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 83.74  E-value: 9.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHGD 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 491560642   93 ASIHARLREAGFSDTLVKPLGRDQLLKAVR 122
Cdd:pfam00072  82 EDDAVEALEAGADDFLSKPFDPDELLAAIR 111
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 12-121 1.00e-19

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 81.36  E-value: 1.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  12 FLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNG---AQLLRELRRSHPDTPALAHT 88
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLGYEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGleaTRRIRELEGGGRRTPIIALT 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491560642  89 ADGDASIHARLREAGFSDTLVKPLGRDQLLKAV 121
Cdd:cd17546   81 ANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 9-149 6.66e-17

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 76.74  E-value: 6.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   9 RPRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRR--SHPDTPALA 86
Cdd:COG3437    6 APTVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRAdpSTRDIPVIF 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491560642  87 HTADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRALVNSPAGIFVAQAPAAVELAVQDWD 149
Cdd:COG3437   86 LTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELDDLVLYLKLAAPLHD 148
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 9-121 3.58e-16

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 73.79  E-value: 3.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   9 RPRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRR--SHPDTPALA 86
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRAdpRTADIPIIF 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491560642  87 HTADGDASIHARLREAGFSDTLVKPLGRDQLLKAV 121
Cdd:COG3706   81 LTALDDEEDRARALEAGADDYLTKPFDPEELLARV 115
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 13-121 4.55e-14

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 66.33  E-value: 4.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHP--DTPALAHTAD 90
Cdd:cd17580    2 LVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWlaNTPAIALTGY 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAV 121
Cdd:cd17580   82 GQPEDRERALEAGFDAHLVKPVDPDELIELI 112
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 6-130 5.26e-14

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 67.63  E-value: 5.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   6 RAARPRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPAL 85
Cdd:COG4567    1 SAEDRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 491560642  86 AHTadGDASIhARLREA---GFSDTLVKPLGRDQLLKAVRRALVNSPA 130
Cdd:COG4567   81 VLT--GYASI-ATAVEAiklGADDYLAKPADADDLLAALERAEGDAPA 125
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 11-111 1.15e-13

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 64.79  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLP--ADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHT 88
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAgfEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|...
gi 491560642  89 ADGDASIHARLREAGFSDTLVKP 111
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLKP 103
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 13-111 2.18e-13

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 63.97  E-value: 2.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDE 80

                         90       100
                 ....*....|....*....|.
gi 491560642  93 asIHARLR--EAGFSDTLVKP 111
Cdd:cd17574   81 --EEDKVLglELGADDYITKP 99
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 26-227 2.38e-13

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 69.11  E-value: 2.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  26 KAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRS--HPDTPALAHTAdgdasiHA------ 97
Cdd:PRK11107 684 GALLEEQVEHVVLCDSGHQAVEQAKQRPFDLILMDIQMPGMDGIRACELIRQLphNQNTPIIAVTA------HAmagere 757

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  98 RLREAGFSDTLVKPLGRDQL----LKAVRRALVNSPAGIFVAQAPAAVELAVQDWDetaalAALNgQRNHLIAL-REL-- 170
Cdd:PRK11107 758 RLLSAGMDDYLAKPIDEAMLkqvlLRYKPGPKFTSRVVAPEPPEPVHFPNATLDWQ-----LALR-QAAGKPDLaRDMlq 831

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491560642 171 -FLAELPGVRDAVEQAVDQHDERQLRSQLHRLQASCGFVGAARLGRAVRQLHHAPESG 227
Cdd:PRK11107 832 mLLDFLPEVRNKVEEALAGEDPEGLLDLIHKLHGSCSYSGVPRLKKLCQLIEQQLRSG 889
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 13-125 1.25e-12

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 62.60  E-value: 1.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:cd17572    2 LLVEDSPSLAALYQEYLSDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITAHGS 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491560642  93 ASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17572   82 VDIAVEAMRLGAYDFLEKPFDADRLRVTVRNAL 114
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 13-111 2.90e-12

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 60.92  E-value: 2.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGd 92
Cdd:cd19935    2 LVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTARD- 80

                         90       100
                 ....*....|....*....|.
gi 491560642  93 aSIHARLR--EAGFSDTLVKP 111
Cdd:cd19935   81 -SVEDRVKglDLGADDYLVKP 100
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 13-125 7.58e-12

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 60.60  E-value: 7.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLP--ADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTAD 90
Cdd:cd17535    2 LIVDDHPLVREGLRRLLESEPdiEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTAH 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17535   82 DDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVA 116
PRK10643 PRK10643
two-component system response regulator PmrA;
11-122 9.61e-12

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 62.36  E-value: 9.61e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTAD 90
Cdd:PRK10643   2 KILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLILTAR 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAVR 122
Cdd:PRK10643  82 DTLEDRVAGLDVGADDYLVKPFALEELHARIR 113
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 12-122 2.11e-11

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 59.04  E-value: 2.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  12 FLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA-D 90
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTArD 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491560642  91 GDASIHARLrEAGFSDTLVKPLGRDQLLKAVR 122
Cdd:cd17624   81 GVDDRVAGL-DAGADDYLVKPFALEELLARLR 111
PRK15347 PRK15347
two component system sensor kinase;
11-227 2.20e-11

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 63.12  E-value: 2.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVED-----DIISRgffkaALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRS----HPD 81
Cdd:PRK15347 692 QILLVDDvetnrDIIGM-----MLVELGQQVTTAASGTEALELGRQHRFDLVLMDIRMPGLDGLETTQLWRDDpnnlDPD 766

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  82 TPALAHTADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAlvnspAGIfvaQAPAAVELAVQDwDETAALAALNgqr 161
Cdd:PRK15347 767 CMIVALTANAAPEEIHRCKKAGMNHYLTKPVTLAQLARALELA-----AEY---QLLRGIELSPQD-SSCSPLLDTD--- 834

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491560642 162 nhLIALRELFLAELPGVRDAVEQAVDQHDErqLRSQLHRLQASCGFVGAARLGRAVRQLHHAPESG 227
Cdd:PRK15347 835 --DMALNSKLYQSLLLLLAQIEQAVENQEV--LSQLLHTLKGCAGQAGLTELQCAVIDLENALETG 896
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 11-125 9.26e-11

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 57.70  E-value: 9.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRsHP---DTPALAH 87
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRK-LPaykFTPILML 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491560642  88 TADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17562   81 TTESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKVL 118
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 13-125 3.03e-10

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 58.28  E-value: 3.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPdTPALAHTADGD 92
Cdd:PRK10529   5 LIVEDEQAIRRFLRTALEGDGMRVFEAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWSA-IPVIVLSARSE 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491560642  93 ASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:PRK10529  84 ESDKIAALDAGADDYLSKPFGIGELQARLRVAL 116
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 10-125 3.04e-10

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 56.13  E-value: 3.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPAD-VDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHT 88
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAGYEvVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491560642  89 ADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17542   81 AMGQEEMVKEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 10-125 4.28e-10

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 55.49  E-value: 4.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPADV-DTADSLASALASAEPGSHDLWLIDVNLPDG-NGAQLLRELRRSHpDTPALAH 87
Cdd:cd17534    1 KKILIVEDEAIIALDLKEILESLGYEVvGIADSGEEAIELAEENKPDLILMDINLKGDmDGIEAAREIREKF-DIPVIFL 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491560642  88 TADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17534   80 TAYSDEETLERAKETNPYGYLVKPFNERELKAAIELAL 117
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 11-136 4.37e-10

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 58.01  E-value: 4.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTAD 90
Cdd:PRK09836   2 KLLIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTGDYDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTAL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAVRRALVNSPAGIFVAQ 136
Cdd:PRK09836  82 GTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIIESQ 127
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 13-122 4.68e-10

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 55.49  E-value: 4.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTadGD 92
Cdd:cd17616    2 LLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILS--GL 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491560642  93 ASIHARLREAGF--SDTLVKPLGRDQLLKAVR 122
Cdd:cd17616   80 ADIEDKVKGLGFgaDDYMTKPFHKDELVARIH 111
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 10-125 4.83e-10

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 55.84  E-value: 4.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETlPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA 89
Cdd:cd17596    1 PTILVVDDEVRSLEALRRTLEE-DFDVLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRIIISG 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491560642  90 DGDAS-IHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17596   80 YTDSEdIIAGINEAGIYQYLTKPWHPDQLLLTVRNAA 116
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 10-89 5.38e-10

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 55.30  E-value: 5.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA 89
Cdd:cd17554    1 KKILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTA 80
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 13-111 1.28e-09

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 53.71  E-value: 1.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELrRSHPDTPALAHTADGD 92
Cdd:cd17620    2 LVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRL-REWSAVPVIVLSARDE 80

                         90
                 ....*....|....*....
gi 491560642  93 ASIHARLREAGFSDTLVKP 111
Cdd:cd17620   81 ESDKIAALDAGADDYLTKP 99
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 13-122 1.33e-09

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 54.15  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALDA 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 491560642  93 ASIHARLREAGFSDTLVKPLGRDQLLKAVR 122
Cdd:cd17625   81 VEDRVKGLDLGADDYLPKPFSLAELLARIR 110
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 11-111 1.48e-09

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 54.17  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPA--DVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHT 88
Cdd:cd19925    2 NVLIVEDDPMVAEIHRAYVEQVPGftVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVT 81

                         90       100
                 ....*....|....*....|...
gi 491560642  89 ADGDASIHARLREAGFSDTLVKP 111
Cdd:cd19925   82 AANDVETVREALRLGVVDYLIKP 104
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 10-120 1.67e-09

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 53.99  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTa 89
Cdd:cd17563    1 KSLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVLT- 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491560642  90 dGDASIhARLREA---GFSDTLVKPLGRDQLLKA 120
Cdd:cd17563   80 -GYASI-ATAVEAiklGADDYLAKPADADEILAA 111
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
13-230 1.82e-09

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 57.44  E-value: 1.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:PRK09959  962 LIADDHPTNRLLLKRQLNLLGYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGLTANAQ 1041

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   93 ASIHARLREAGFSDTLVKPLGRDQLLKAVRRalVNSPAGIfvaqAPAAVELAVQdwdetaalAALNGQRNHLIALRELFL 172
Cdd:PRK09959 1042 ANEREKGLSCGMNLCLFKPLTLDVLKTHLSQ--LHQVAHI----APQYRHLDIE--------ALKNNTANDLQLMQEILM 1107

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491560642  173 A-------ELPGVRDAVEQAvdqhDERQLRSQLHRLQASCGFVGAARLGRAVRQLHHAPESGQAQ 230
Cdd:PRK09959 1108 TfqhethkDLPAAFHALEAG----DNRTFHQCIHRIHGAANILNLQKLINISHQLEITPVSDDSK 1168
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
 13-117 2.10e-09

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 53.79  E-value: 2.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALA--SAEPGSHDLWLIDVNLPDGNGAQLLrELRRSHPDTPALAHTAD 90
Cdd:cd17584    2 LVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSmlRENKDEFDLVITDVHMPDMDGFEFL-ELIRLEMDLPVIMMSAD 80

                         90       100
                 ....*....|....*....|....*..
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQL 117
Cdd:cd17584   81 GSTSTVMKGLAHGACDYLLKPVSIEDL 107
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 11-125 3.11e-09

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 53.32  E-value: 3.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPA-DVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELrRSHPDT---PALA 86
Cdd:cd17552    3 RILVIDDEEDIREVVQACLEKLAGwEVLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKL-QANPETqsiPVIL 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491560642  87 HTADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17552   82 LTAKAQPSDRQRFASLGVAGVIAKPFDPLTLAEQIAKLL 120
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 13-123 4.93e-09

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 52.69  E-value: 4.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELrRSHPDTPALAHTADGD 92
Cdd:cd17623    2 LLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKEL-RKTSQVPVLMLTARGD 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491560642  93 ASIHARLREAGFSDTLVKPLGRDQL---LKAVRR 123
Cdd:cd17623   81 DIDRILGLELGADDYLPKPFNPRELvarIRAILR 114
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 12-119 8.56e-09

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 51.88  E-value: 8.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  12 FLLVEDDIISRGFFKAALETLPA-DVDTADSLASALASAEPGSHDLWLIDVNLPDG-NGAQLLRELRRSH---PDTPALA 86
Cdd:cd17589    1 FLIVDDQPTFRSMLKSMLRSLGVtRIDTASSGEEALRMCENKTYDIVLCDYNLGKGkNGQQLLEELRHKKlisPSTVFIM 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491560642  87 HTADGDASIHARLREAGFSDTLVKPLGRDQLLK 119
Cdd:cd17589   81 VTGESSRAMVLSALELEPDDYLLKPFTVSELRE 113
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 10-124 9.31e-09

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 51.82  E-value: 9.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA 89
Cdd:cd17555    1 ATILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSG 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491560642  90 DGDAS--IHArLREaGFSDTLVKPLgRDQ--LLKAVRRA 124
Cdd:cd17555   81 AGVMSdaVEA-LRL-GAWDYLTKPI-EDLavLEHAVRRA 116
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 10-122 1.00e-08

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 52.06  E-value: 1.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPAD--VDTADSLAsALASAEPGSHDLWLIDVNLPDGNGAQLLRELRR--SHPDTPAL 85
Cdd:cd17551    1 MRILIVDDNPTNLLLLEALLRSAGYLevVSFTDPRE-ALAWCRENPPDLILLDYMMPGMDGLEFIRRLRAlpGLEDVPIV 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491560642  86 AHTADGDASIhaRLR--EAGFSDTLVKPLGRDQLLKAVR 122
Cdd:cd17551   80 MITADTDREV--RLRalEAGATDFLTKPFDPVELLARVR 116
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 11-111 1.19e-08

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 51.35  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSH-DLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA 89
Cdd:cd18160    1 TILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREARKIDPDVKILFISG 80

                         90       100
                 ....*....|....*....|..
gi 491560642  90 DGDASIHARLREAGFSDTLVKP 111
Cdd:cd18160   81 GAAAAPELLSDAVGDNATLKKP 102
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 11-125 1.19e-08

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 53.42  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADV-DTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPdTPALAHTA 89
Cdd:COG3707    5 RVLVVDDEPLRRADLREGLREAGYEVvAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERP-APVILLTA 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491560642  90 DGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:COG3707   84 YSDPELIERALEAGVSAYLVKPLDPEDLLPALELAL 119
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 13-123 1.51e-08

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 51.39  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRrSHPDT---PALAHTA 89
Cdd:cd17548    3 LIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLK-EDPATrdiPVIALTA 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491560642  90 ---DGDASihaRLREAGFSDTLVKPLGRDQLLKAVRR 123
Cdd:cd17548   82 yamKGDRE---KILEAGCDGYISKPIDTREFLETVAK 115
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 13-112 1.65e-08

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 54.56  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVED----DIISRgffkAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPD---TPAL 85
Cdd:PRK11091 529 LLVEDielnVIVAR----SVLEKLGNSVDVAMTGKEALEMFDPDEYDLVLLDIQLPDMTGLDIARELRERYPRedlPPLV 604

                         90       100
                 ....*....|....*....|....*....
gi 491560642  86 AHTADgdaSIHAR--LREAGFSDTLVKPL 112
Cdd:PRK11091 605 ALTAN---VLKDKkeYLDAGMDDVLSKPL 630
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 11-117 1.97e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 51.18  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETL-PADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSH--PDTPALAH 87
Cdd:cd19923    2 KVLVVDDFSTMRRIIKNLLKELgFNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGalSHLPVLMV 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 491560642  88 TADGDASIHARLREAGFSDTLVKPLGRDQL 117
Cdd:cd19923   82 TAEAKKENVIAAAQAGVNNYIVKPFTAATL 111
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 35-125 2.67e-08

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 50.57  E-value: 2.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  35 DVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGDASIHARLREAGFSDTLVKPLGR 114
Cdd:cd17550   24 EVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMISGHGTIETAVKATKLGAYDFIEKPLSL 103

                         90
                 ....*....|.
gi 491560642 115 DQLLKAVRRAL 125
Cdd:cd17550  104 DRLLLTIERAL 114
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 10-122 2.69e-08

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 50.46  E-value: 2.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRsHPDTPALAHTA 89
Cdd:cd17619    1 PHILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELRE-QSEVGIILVTG 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491560642  90 DGDASIHARLREAGFSDTLVKPLGRDQLLKAVR 122
Cdd:cd17619   80 RDDEVDRIVGLEIGADDYVTKPFNPRELLVRAK 112
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 11-240 4.31e-08

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 53.37  E-value: 4.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALAS-AEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA 89
Cdd:PRK11466 683 RLLLIEDNPLTQRITAEMLNTSGAQVVAVGNAAQALETlQNSEPFAAALVDFDLPDYDGITLARQLAQQYPSLVLIGFSA 762

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  90 DG-DASIHARLREAgFSDTLVKPLGRDQLLKAVRRALVnspagifvAQAPAAVELAVQDWDETAALAALNGQRNHLIALR 168
Cdd:PRK11466 763 HViDETLRQRTSSL-FRGIIPKPVPREVLGQLLAHYLQ--------LQVNNDQPLDVSQLNEDAALMGTEKIHEWLALFK 833

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491560642 169 ELFLAELpgvrDAVEQAVDQHDERQLRSQLHRLQASCGFVGAARLGRAVRQLHHAPESGQAQAG-FRDAVAAL 240
Cdd:PRK11466 834 QHALPLL----DEIDIARASQDSEKIKRAAHQLKSSCSSLGMRQASQACAQLEQQPLSAPLPHEeITRSVAAL 902
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 13-125 5.33e-08

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 51.74  E-value: 5.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPAD--VDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTAD 90
Cdd:COG3279    5 LIVDDEPLARERLERLLEKYPDLevVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFTTAY 84

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491560642  91 GDasiHArLR--EAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:COG3279   85 DE---YA-LEafEVNAVDYLLKPIDEERLAKALEKAK 117
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 11-122 7.96e-08

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 49.27  E-value: 7.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTAD 90
Cdd:cd17615    1 RVLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTAK 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAVR 122
Cdd:cd17615   81 DSVEDRIAGLTAGGDDYVTKPFSLEEVVARLR 112
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 13-126 8.70e-08

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 49.20  E-value: 8.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:cd19934    2 LLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTARDS 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491560642  93 ASIHARLREAGFSDTLVKPLGRDQLLkAVRRALV 126
Cdd:cd19934   82 WQDKVEGLDAGADDYLTKPFHIEELL-ARLRALI 114
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 14-125 9.68e-08

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 50.48  E-value: 9.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  14 LVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGDA 93
Cdd:COG4566    4 IVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGHGDV 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491560642  94 SIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:COG4566   84 PMAVRAMKAGAVDFLEKPFDDQALLDAVRRAL 115
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
7-125 1.70e-07

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 51.39  E-value: 1.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   7 AARPRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALA 86
Cdd:PRK11361   2 TAINRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVIL 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491560642  87 HTADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:PRK11361  82 MTAYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRAL 120
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 13-125 2.01e-07

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 48.15  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:cd17627    2 LVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARDS 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491560642  93 ASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17627   82 VSDRVAGLDAGADDYLVKPFALEELLARVRALL 114
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
13-128 4.02e-07

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 50.03  E-value: 4.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:PRK10365   9 LVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTAYSS 88

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491560642  93 ASIHARLREAGFSDTLVKPLGRDQLLKAVRRALVNS 128
Cdd:PRK10365  89 VETAVEALKTGALDYLIKPLDFDNLQATLEKALAHT 124
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 13-111 4.45e-07

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 47.11  E-value: 4.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:cd19928    2 LVADDDRAIRTVLTQALGRAGYEVRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQNT 81

                         90
                 ....*....|....*....
gi 491560642  93 ASIHARLREAGFSDTLVKP 111
Cdd:cd19928   82 LMTAVKAAERGAFEYLPKP 100
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 13-125 4.88e-07

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 47.48  E-value: 4.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRgffKAALETLPA---DVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA 89
Cdd:cd17549    2 LLVDDDADVR---EALQQTLELagfRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITG 78

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491560642  90 DGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17549   79 HGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVRRAL 114
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 14-125 5.09e-07

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 47.27  E-value: 5.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  14 LVEDDIISRGFFKAALETLPADV---DTADSLASALASAEPgshDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA- 89
Cdd:cd19919    5 IVDDDSSIRWVLERALAGAGLTVtsfENAQEALAALASSQP---DVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAh 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491560642  90 -DGDASIHArlREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd19919   82 sDLDSAVSA--YQGGAFEYLPKPFDIDEAVALVERAI 116
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 11-117 5.85e-07

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 47.01  E-value: 5.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALA--SAEPGSHDLWLIDVNLPDGNGAQL---LRELRRSHPDTPAL 85
Cdd:cd19933    2 KVLLVDDNAVNRMVTKGLLEKLGCEVTTVSSGEECLNllASAEHSFQLVLLDLCMPEMDGFEValrIRKLFGRRERPLIV 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491560642  86 AHTADGDASIHARLREAGFSDTLVKPLGRDQL 117
Cdd:cd19933   82 ALTANTDDSTREKCLSLGMNGVITKPVSLHAL 113
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 10-125 5.89e-07

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 47.01  E-value: 5.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHT- 88
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRILLTg 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491560642  89 -ADGDASIHArLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17569   81 yADLDAAIEA-INEGEIYRFLTKPWDDEELKETIRQAL 117
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 14-125 5.99e-07

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 46.82  E-value: 5.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  14 LVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGDA 93
Cdd:cd17537    5 VVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITGHGDV 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491560642  94 SIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17537   85 PMAVEAMKAGAVDFLEKPFRDQVLLDAIEQAL 116
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 14-139 6.08e-07

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 49.48  E-value: 6.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  14 LVEDD-----IISRGFFKAALETlpADVDTADSLASALASAEPgshDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHT 88
Cdd:PRK10923   8 VVDDDssirwVLERALAGAGLTC--TTFENGNEVLEALASKTP---DVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMT 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491560642  89 A--DGDASIHArlREAGFSDTLVKPLGRDQLLKAVRRAL-------------VNSPAGIFVAQAPA 139
Cdd:PRK10923  83 AhsDLDAAVSA--YQQGAFDYLPKPFDIDEAVALVERAIshyqeqqqprniqVNGPTTDIIGEAPA 146
PRK13557 PRK13557
histidine kinase; Provisional
 6-132 8.22e-07

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 49.28  E-value: 8.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   6 RAARPRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSH-DLWLIDVNLPDG-NGAQLLRELRRSHPDTP 83
Cdd:PRK13557 412 RGGTETILIVDDRPDVAELARMILEDFGYRTLVASNGREALEILDSHPEvDLLFTDLIMPGGmNGVMLAREARRRQPKIK 491

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 491560642  84 ALAHTADGDASIhaRLREAGFS--DTLVKPLGRDQLLKAVRRALvNSPAGI 132
Cdd:PRK13557 492 VLLTTGYAEASI--ERTDAGGSefDILNKPYRRAELARRVRMVL-DGPTGV 539
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 10-64 8.43e-07

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 44.87  E-value: 8.43e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 491560642    10 PRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLP 64
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEKPDLILLDIMMP 55
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
11-146 9.75e-07

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 48.18  E-value: 9.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALET---LPADVDTADSLASALASAEPgshDLWLIDVNLPDGNGAQLLRELRRSH--PDTPAL 85
Cdd:PRK10161   4 RILVVEDEAPIREMVCFVLEQngfQPVEAEDYDSAVNQLNEPWP---DLILLDWMLPGGSGIQFIKHLKRESmtRDIPVV 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491560642  86 AHTADGDASIHARLREAGFSDTLVKPLGRDQL---LKAVRRALvnspagifvaqAPAAVELAVQ 146
Cdd:PRK10161  81 MLTARGEEEDRVRGLETGADDYITKPFSPKELvarIKAVMRRI-----------SPMAVEEVIE 133
PRK11517 PRK11517
DNA-binding response regulator HprR;
11-125 1.69e-06

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 47.59  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHpDTPALAHTAD 90
Cdd:PRK11517   2 KILLIEDNQRTQEWVTQGLSEAGYVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAK-QTPVICLTAR 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:PRK11517  81 DSVDDRVRGLDSGANDYLVKPFSFSELLARVRAQL 115
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 10-121 2.15e-06

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 45.32  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRS--HPDTPALAH 87
Cdd:cd17618    1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDemTRDIPIIML 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 491560642  88 TADGDASIHARLREAGFSDTLVKPLGRDQLL---KAV 121
Cdd:cd17618   81 TARGEEEDKVRGLEAGADDYITKPFSPRELVariKAV 117
REC_PFxFATGY cd17586
phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response ...
 13-125 2.86e-06

phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators; This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381122 [Multi-domain]  Cd Length: 111  Bit Score: 44.77  E-value: 2.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLP-ADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRShpDTPALAHTADG 91
Cdd:cd17586    2 LVLEDEPLIAMNLEDALEDLGgKEVVTAATCAEALRSLADGPIDIAILDVNLGGETSIPVADALKRR--AIPFIFATGYG 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491560642  92 D-ASIHARLREAgfsDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17586   80 DsHGIDSRLIDV---PVLRKPFDADSALAALAMLL 111
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 13-111 4.34e-06

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 44.07  E-value: 4.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:cd19926    2 LVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAYGS 81

                         90
                 ....*....|....*....
gi 491560642  93 ASIHARLREAGFSDTLVKP 111
Cdd:cd19926   82 LDTAIEALKAGAFDFLTKP 100
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 11-75 5.88e-06

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 44.50  E-value: 5.88e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491560642  11 RFLLVEDDIISRGFFKAALETLP--ADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLREL 75
Cdd:COG2197    3 RVLIVDDHPLVREGLRALLEAEPdiEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL 69
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
11-128 8.03e-06

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 45.56  E-value: 8.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEpGSHDLWLIDVNLPDGNGAQLLRELRRSHpDTPALAHTAD 90
Cdd:PRK10955   3 KILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLD-DSIDLLLLDVMMPKKNGIDTLKELRQTH-QTPVIMLTAR 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAVRRALVNS 128
Cdd:PRK10955  81 GSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRS 118
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 11-111 8.69e-06

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 43.26  E-value: 8.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSH--PDTPALAHT 88
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPetRHIPVIMIT 80

                         90       100
                 ....*....|....*....|....*
gi 491560642  89 ADGDAsiHARLR--EAGFSDTLVKP 111
Cdd:cd17538   81 ALDDR--EDRIRglEAGADDFLSKP 103
fixJ PRK09390
response regulator FixJ; Provisional
 37-131 1.27e-05

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 44.61  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  37 DTADSLASALASAEPGshdLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGDASIHARLREAGFSDTLVKPLGRDQ 116
Cdd:PRK09390  34 ESAQAFLDALPGLRFG---CVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTGHGDVPLAVEAMKLGAVDFIEKPFEDER 110

                         90
                 ....*....|....*
gi 491560642 117 LLKAVRRALVNSPAG 131
Cdd:PRK09390 111 LIGAIERALAQAPEA 125
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
 13-118 1.52e-05

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 42.80  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPA--LAHTAD 90
Cdd:cd17573    2 LLIEDDSTLGKEISKGLNEKGYQADVAESLKDGEYYIDIRNYDLVLVSDKLPDGNGLSIVSRIKEKHPSIVVivLSDNPK 81

                         90       100
                 ....*....|....*....|....*...
gi 491560642  91 GDASIHArLREaGFSDTLVKPLGRDQLL 118
Cdd:cd17573   82 TEQEIEA-FKE-GADDYIAKPFDFKVLV 107
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 13-111 1.53e-05

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 42.72  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSH-DLWLIDVNLPDG-NGAQLLRELRRSHPDTPALAHTAD 90
Cdd:cd18161    2 LVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLESGPDiDLLVTDVIMPGGmNGSQLAEEARRRRPDLKVLLTSGY 81

                         90       100
                 ....*....|....*....|.
gi 491560642  91 GDASIHARLREAGFsDTLVKP 111
Cdd:cd18161   82 AENAIEGGDLAPGV-DVLSKP 101
dpiA PRK10046
two-component response regulator DpiA; Provisional
 12-123 1.64e-05

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 44.62  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  12 FLLVEDDIISRGFFKAALETLPA--DVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA 89
Cdd:PRK10046   7 LLIVEDETPLAEMHAEYIRHIPGfsQILLAGNLAQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGDVVFTTA 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491560642  90 DGDASIHARLREAGFSDTLVKPLGRDQLLKAVRR 123
Cdd:PRK10046  87 ASDMETVSEAVRCGVFDYLIKPIAYERLGQTLTR 120
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 13-111 2.31e-05

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 42.51  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEpgSH---DLWLIDVNLPDGNGAQLLRELRRSHP--DTPALAH 87
Cdd:cd17544    4 LVVDDSATSRNHLRALLRRHNFQVLEAANGQEALEVLE--QHpdiKLVITDYNMPEMDGFELVREIRKKYSrdQLAIIGI 81

                         90       100
                 ....*....|....*....|....
gi 491560642  88 TADGDASIHARLREAGFSDTLVKP 111
Cdd:cd17544   82 SASGDNALSARFIKAGANDFLTKP 105
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 10-92 2.79e-05

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 43.80  E-value: 2.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA 89
Cdd:PRK11083   4 PTILLVEDEQAIADTLVYALQSEGFTVEWFERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLTA 83


                 ...
gi 491560642  90 DGD 92
Cdd:PRK11083  84 RSD 86
PRK15115 PRK15115
response regulator GlrR; Provisional
 11-131 3.10e-05

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 44.44  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTAD 90
Cdd:PRK15115   7 HLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILTAH 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAVRRALVNS-PAG 131
Cdd:PRK15115  87 GSIPDAVAATQQGVFSFLTKPVDRDALYKAIDDALEQSaPAT 128
Hpt pfam01627
Hpt domain; The histidine-containing phosphotransfer (HPt) domain is a novel protein module ...
 167-231 3.29e-05

Hpt domain; The histidine-containing phosphotransfer (HPt) domain is a novel protein module with an active histidine residue that mediates phosphotransfer reactions in the two-component signaling systems. A multistep phosphorelay involving the HPt domain has been suggested for these signaling pathways. The crystal structure of the HPt domain of the anaerobic sensor kinase ArcB has been determined. The domain consists of six alpha helices containing a four-helix bundle-folding. The pattern of sequence similarity of the HPt domains of ArcB and components in other signaling systems can be interpreted in light of the three-dimensional structure and supports the conclusion that the HPt domains have a common structural motif both in prokaryotes and eukaryotes. In S. cerevisiae ypd1p this domain has been shown to contain a binding surface for Ssk1p (response regulator receiver domain containing protein pfam00072).


Pssm-ID: 426352 [Multi-domain]  Cd Length: 84  Bit Score: 41.18  E-value: 3.29e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491560642  167 LRELFLAELPGVRDAVEQAVDQHDERQLRSQLHRLQASCGFVGAARLGRAVRQLHHAPESGQAQA 231
Cdd:pfam01627   2 LLELFLEEAPELLEQLEQALDAEDLEALFRAAHTLKGSAGSLGLPALAELAHELEDLLREGELPL 66
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 11-118 3.55e-05

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 42.04  E-value: 3.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETL-PADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTA 89
Cdd:cd17530    2 RVLVLDDDPFQCMMAATILEDLgPGNVDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILMSG 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491560642  90 DGDASIHARLREAG-----FSDTLVKPLGRDQLL 118
Cdd:cd17530   82 LDGGILESAETLAGanglnLLGTLSKPFSPEELT 115
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 11-125 5.72e-05

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 41.21  E-value: 5.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHpDTPALAHTAD 90
Cdd:cd17622    2 RILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKY-QGPILLLTAL 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17622   81 DSDIDHILGLELGADDYVVKPVEPAVLLARLRALL 115
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 13-123 8.48e-05

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 41.25  E-value: 8.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDD-----IISRGFFKAaleTLPADVDTADSLASALA-------SAEPGSHDLWLIDVNLPDGNGAQLLRELRRShp 80
Cdd:cd17557    3 LLVEDNpgdaeLIQEAFKEA---GVPNELHVVRDGEEALDflrgegeYADAPRPDLILLDLNMPRMDGFEVLREIKAD-- 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 491560642  81 dtPALAH-------TADGDASIhARLREAGFSDTLVKPLGRDQLLKAVRR 123
Cdd:cd17557   78 --PDLRRipvvvltTSDAEEDI-ERAYELGANSYIVKPVDFEEFVEAIRS 124
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 13-125 8.54e-05

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 40.87  E-value: 8.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVED-----DIISRGFFKAALEtlpadVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHpDTPALAH 87
Cdd:cd17614    2 LVVDDekpisDILKFNLTKEGYE-----VVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTS-NVPIIML 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491560642  88 TADgDASIHARL-REAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17614   76 TAK-DSEVDKVLgLELGADDYVTKPFSNRELLARVKANL 113
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 13-122 1.04e-04

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 40.51  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRShPDTPALAHTADGD 92
Cdd:cd17594    3 LVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRAR-SDVPIIIISGDRR 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491560642  93 ASIHARL-REAGFSDTLVKPLGRDQLLKAVR 122
Cdd:cd17594   82 DEIDRVVgLELGADDYLAKPFGLRELLARVR 112
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 13-76 1.98e-04

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 39.96  E-value: 1.98e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELR 76
Cdd:cd18159    2 LIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIR 65
PRK15479 PRK15479
transcriptional regulator TctD;
11-132 2.07e-04

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 41.25  E-value: 2.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTAD 90
Cdd:PRK15479   2 RLLLAEDNRELAHWLEKALVQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTAR 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQlLKAVRRALVNSPAGI 132
Cdd:PRK15479  82 SAVADRVKGLNVGADDYLPKPFELEE-LDARLRALLRRSAGQ 122
REC_1_GGDEF cd19921
first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 11-123 2.19e-04

first phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the first REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381148 [Multi-domain]  Cd Length: 115  Bit Score: 39.86  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDD-IISRGFFKAALETLPADVDTADSLASALAS-AEPGSHDLWLIDVNLPDGNGAQLLRELRRSHpdTPALAHT 88
Cdd:cd19921    1 KVLIVEDSkTFSKVLKHLIAQELGLEVDVAETLAEAKALlEEGDDYFAALVDLNLPDAPNGEAVDLVLEKG--IPVIVLT 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 491560642  89 ADGDASIHARLREAGFSDTLVKPlGR---DQLLKAVRR 123
Cdd:cd19921   79 GSFDEDKRETLLSKGVVDYVLKD-SRysyDYVVKLVRR 115
PRK10766 PRK10766
two-component system response regulator TorR;
13-79 3.68e-04

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 40.41  E-value: 3.68e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELR-RSH 79
Cdd:PRK10766   6 LVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRsRST 73
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 13-123 3.85e-04

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 39.18  E-value: 3.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRS--HPDTPALAHTAD 90
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDpkTSSIPIIMLTAK 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLL---KAVRR 123
Cdd:cd19937   81 GEEFDKVLGLELGADDYITKPFSPRELLarvKAVLR 116
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 40-111 4.47e-04

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 38.50  E-value: 4.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491560642  40 DSLaSALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSH--PDTPALAHTADGDASIHARLREAGFSDTLVKP 111
Cdd:cd17602   30 DPL-RALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKSSalKDTPIIMLTGKDGLVDRIRAKMAGASGYLTKP 102
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 11-125 5.34e-04

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 38.55  E-value: 5.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADV-DTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPdTPALAHTA 89
Cdd:cd19932    2 RVLIAEDEALIRMDLREMLEEAGYEVvGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVLLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491560642  90 DGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAI 116
PRK11173 PRK11173
two-component response regulator; Provisional
 10-76 8.71e-04

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 39.61  E-value: 8.71e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491560642  10 PRFLLVEDDIISRGFFKAALETLPADVDTA---DSLASALASaepgsHDLWLI--DVNLPDGNGAQLLRELR 76
Cdd:PRK11173   4 PHILIVEDELVTRNTLKSIFEAEGYDVFEAtdgAEMHQILSE-----NDINLVimDINLPGKNGLLLARELR 70
HPtr COG2198
HPt (histidine-containing phosphotransfer) domain [Signal transduction mechanisms];
27-231 8.81e-04

HPt (histidine-containing phosphotransfer) domain [Signal transduction mechanisms];


Pssm-ID: 441800 [Multi-domain]  Cd Length: 871  Bit Score: 40.41  E-value: 8.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  27 AALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGDASIHARLREAGFSD 106
Cdd:COG2198  641 LLLLLLLLLLLLAVLLAAAAAAAALAALDLLLDLDDMMMMLDDMMAEAARARALAARAAAIAAAAAAAAAAAAAAAAAAA 720

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642 107 TLVKPLGRDQLLKAVRRALVNSPAGIFVAQAPAAVELAVQDWDETAALAALNGQRNHLIALRELFLAELPGVRDAVEQAV 186
Cdd:COG2198  721 ALLAALLLLLLLLLLLLLLLLLLLLAAAAAAAASPAAPALPVLDLEALRRLGGDPELLRELLELFLEELPELLAELRQAL 800

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 491560642 187 DQHDERQLRSQLHRLQASCGFVGAARLGRAVRQLHHAPESGQAQA 231
Cdd:COG2198  801 AAGDLEALARLAHKLKGSAGNLGAPRLAELAAELEQAARAGDLEE 845
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
13-117 1.14e-03

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 39.96  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTADGD 92
Cdd:PRK10841 805 LVVDDHPINRRLLADQLGSLGYQCKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQLGLTLPVIGVTANAL 884

                         90       100
                 ....*....|....*....|....*
gi 491560642  93 ASIHARLREAGFSDTLVKPLGRDQL 117
Cdd:PRK10841 885 AEEKQRCLEAGMDSCLSKPVTLDVL 909
PRK10816 PRK10816
two-component system response regulator PhoP;
11-111 1.17e-03

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 38.95  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASA---LASAEPgshDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAH 87
Cdd:PRK10816   2 RVLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEAdyyLNEHLP---DIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVL 78

                         90       100
                 ....*....|....*....|....
gi 491560642  88 TADGDASIHARLREAGFSDTLVKP 111
Cdd:PRK10816  79 TARESWQDKVEVLSAGADDYVTKP 102
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 11-125 1.21e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 37.45  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRrSHPDTPALAHTAD 90
Cdd:cd17626    2 RILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIR-AESGVPIVMLTAK 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd17626   81 SDTVDVVLGLESGADDYVAKPFKPKELVARIRARL 115
PRK10610 PRK10610
chemotaxis protein CheY;
11-112 1.37e-03

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 37.65  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLP-ADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRR--SHPDTPALAH 87
Cdd:PRK10610   7 KFLVVDDFSTMRRIVRNLLKELGfNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRAdgAMSALPVLMV 86

                         90       100
                 ....*....|....*....|....*
gi 491560642  88 TADGDASIHARLREAGFSDTLVKPL 112
Cdd:PRK10610  87 TAEAKKENIIAAAQAGASGYVVKPF 111
pleD PRK09581
response regulator PleD; Reviewed
 3-122 2.13e-03

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 38.73  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642   3 MTPRaarprfLLVEDDIIS-RGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELrRSHPD 81
Cdd:PRK09581   1 MTAR------ILVVDDIPAnVKLLEAKLLAEYYTVLTASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRL-KSDPA 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 491560642  82 T---PALAHTADGDASIHARLREAGFSDTLVKPLGRDQLLKAVR 122
Cdd:PRK09581  74 TthiPVVMVTALDDPEDRVRGLEAGADDFLTKPINDVALFARVK 117
PRK10336 PRK10336
two-component system response regulator QseB;
11-112 7.01e-03

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 36.80  E-value: 7.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVEDDIISRGFFKAALETLPADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTAD 90
Cdd:PRK10336   2 RILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTAR 81

                         90       100
                 ....*....|....*....|..
gi 491560642  91 GDASIHARLREAGFSDTLVKPL 112
Cdd:PRK10336  82 DALAERVEGLRLGADDYLCKPF 103
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 13-125 8.23e-03

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 35.40  E-value: 8.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  13 LLVEDDIISRGFFKAALETLP--ADVDTADSLASALASAEPGSHDLWLIDVNLPDGNGAQLLRELRRSHPDTPALAHTAD 90
Cdd:cd19931    2 LLIDDHPLLRKGIKQLIELDPdfTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTVS 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 491560642  91 GDASIHARLREAGFSDTLVKPLGRDQLLKAVRRAL 125
Cdd:cd19931   82 DAEDDVVTALRAGADGYLLKDMEPEDLLEALKQAA 116
PRK15369 PRK15369
two component system response regulator;
11-127 9.86e-03

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 36.21  E-value: 9.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491560642  11 RFLLVED-DIISRGFfKAALETLP-----ADVDTADSLASALASAEPgshDLWLIDVNLPDGNGAQLLRELRRSHPDTPA 84
Cdd:PRK15369   5 KILLVDDhELIINGI-KNMLAPYPrykivGQVDNGLEVYNACRQLEP---DIVILDLGLPGMNGLDVIPQLHQRWPAMNI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491560642  85 LAHTADGDASIHARLREAGFSDTLVKPLGRDQLLKAVRRALVN 127
Cdd:PRK15369  81 LVLTARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVG 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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