|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
8-372 |
7.37e-127 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 370.97 E-value: 7.37e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 8 PFALSLAIAATVAACGGQPQAPEQGPG---DVTVVTLKSETVGLTRELPGRTNAYLVAEVRPQVNGIVAKRLFTEGGMVK 84
Cdd:PRK15030 9 PLAVVLMLSGSLALTGCDDKQAQQGGQqmpAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 85 AGEPLYQIEDASYRAQANSARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAAN 164
Cdd:PRK15030 89 AGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETAR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 165 VTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRL-QDNQTLPVSILM 243
Cdd:PRK15030 169 INLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLkQENGKAKVSLIT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 244 EDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGK 323
Cdd:PRK15030 249 SDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGA 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 491561842 324 DNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATE 372
Cdd:PRK15030 329 DDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQE 377
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
36-371 |
2.38e-102 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 305.78 E-value: 2.38e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 36 VTVVTLKSETVGLTRELPGRTNAYLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATA 115
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 116 NAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQ 195
Cdd:TIGR01730 81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 196 anALATVQQLDPIYVDLTQSSAELLQLRRelaagrlqdNQTLPVSILMEDGstFEHKGTLEFSEVSVDPTTGSFGLRVKV 275
Cdd:TIGR01730 161 --TLATIVDLDPLEADFSVPERDLPQLRR---------GQTLTVELDALPG--EEFKGKLRFIDPRVDSGTGTVRVRATF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 276 DNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDtTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVI 355
Cdd:TIGR01730 228 PNPDGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNGK-YVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIV 306
|
330
....*....|....*.
gi 491561842 356 VEGLQKIGPGMPVKAT 371
Cdd:TIGR01730 307 TAGVVKLRDGAKVKVV 322
|
|
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
40-374 |
8.11e-97 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 291.85 E-value: 8.11e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 40 TLKSETVGLTRELPGRTNAYLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATANAAR 119
Cdd:COG0845 2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 120 LSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQanAL 199
Cdd:COG0845 82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT--PL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 200 ATVQQLDPIYVDLTQSSAELLQLRRElaagrlqdnqtLPVSILMEDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPD 279
Cdd:COG0845 160 FTIADLDPLEVEFDVPESDLARLKVG-----------QPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPD 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 280 GLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDtTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGL 359
Cdd:COG0845 229 GLLRPGMFVRVRIVLGERENALLVPASAVVRDGGGA-YVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGL 307
|
330
....*....|....*
gi 491561842 360 QKIGPGMPVKATEKG 374
Cdd:COG0845 308 QRLRDGAKVRVVEAA 322
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
45-356 |
1.62e-63 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 206.12 E-value: 1.62e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 45 TVGLTRELPGRTNAYLVAE-VRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATANAARLSAK 123
Cdd:pfam00529 3 PLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 124 RITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQ 203
Cdd:pfam00529 83 RLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLATVA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 204 QLDPIYVDLTQSSAELLQLRRELAAGRLQDNQTLPVSILM--EDGSTFEHK----GTLEFSEVSVDPTTGSFGLRVKVDN 277
Cdd:pfam00529 163 QLDQIYVQITQSAAENQAEVRSELSGAQLQIAEAEAELKLakLDLERTEIRapvdGTVAFLSVTVDGGTVSAGLRLMFVV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 278 P-DGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIV 356
Cdd:pfam00529 243 PeDNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSAGALVRL 322
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15030 |
PRK15030 |
multidrug efflux RND transporter periplasmic adaptor subunit AcrA; |
8-372 |
7.37e-127 |
|
multidrug efflux RND transporter periplasmic adaptor subunit AcrA;
Pssm-ID: 184990 [Multi-domain] Cd Length: 397 Bit Score: 370.97 E-value: 7.37e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 8 PFALSLAIAATVAACGGQPQAPEQGPG---DVTVVTLKSETVGLTRELPGRTNAYLVAEVRPQVNGIVAKRLFTEGGMVK 84
Cdd:PRK15030 9 PLAVVLMLSGSLALTGCDDKQAQQGGQqmpAVGVVTVKTEPLQITTELPGRTSAYRIAEVRPQVSGIILKRNFKEGSDIE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 85 AGEPLYQIEDASYRAQANSARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAAN 164
Cdd:PRK15030 89 AGVSLYQIDPATYQATYDSAKGDLAKAQAAANIAQLTVNRYQKLLGTQYISKQEYDQALADAQQANAAVTAAKAAVETAR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 165 VTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRL-QDNQTLPVSILM 243
Cdd:PRK15030 169 INLAYTKVTSPISGRIGKSNVTEGALVQNGQATALATVQQLDPIYVDVTQSSNDFLRLKQELANGTLkQENGKAKVSLIT 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 244 EDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGK 323
Cdd:PRK15030 249 SDGIKFPQDGTLEFSDVTVDQTTGSITLRAIFPNPDHTLLPGMFVRARLEEGLNPNAILVPQQGVTRTPRGDATVLVVGA 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 491561842 324 DNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATE 372
Cdd:PRK15030 329 DDKVETRPIVASQAIGDKWLVTEGLKAGDRVVISGLQKVRPGVQVKAQE 377
|
|
| PRK09859 |
PRK09859 |
multidrug transporter subunit MdtE; |
13-370 |
7.74e-106 |
|
multidrug transporter subunit MdtE;
Pssm-ID: 137559 [Multi-domain] Cd Length: 385 Bit Score: 317.04 E-value: 7.74e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 13 LAIAATVAACGGQP-QAPEQGPGDVTVVTLKSETVGLTRELPGRTNAYLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQ 91
Cdd:PRK09859 12 LFCGAMLTACDDKSaENAAAMTPEVGVVTLSPGSVNVLSELPGRTVPYEVAEIRPQVGGIIIKRNFIEGDKVNQGDSLYQ 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 92 IEDASYRAQANSARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYAR 171
Cdd:PRK09859 92 IDPAPLQAELNSAKGSLAKALSTASNARITFNRQASLLKTNYVSRQDYDTARTQLNEAEANVTVAKAAVEQATINLQYAN 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 172 ITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRLQDNQ-TLPVSILMEDGSTFE 250
Cdd:PRK09859 172 VTSPITGVSGKSSVTVGALVTANQADSLVTVQRLDPIYVDLTQSVQDFLRMKEEVASGQIKQVQgSTPVQLNLENGKRYS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 251 HKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGKDNKVEVR 330
Cdd:PRK09859 252 QTGTLKFSDPTVDETTGSVTLRAIFPNPNGDLLPGMYVTALVDEGSRQNVLLVPQEGVTHNAQGKATALILDKDDVVQLR 331
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 491561842 331 PVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKA 370
Cdd:PRK09859 332 EIEASKAIGDQWVVTSGLQAGDRVIVSGLQRIRPGIKARA 371
|
|
| RND_mfp |
TIGR01730 |
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion ... |
36-371 |
2.38e-102 |
|
RND family efflux transporter, MFP subunit; This model represents the MFP (membrane fusion protein) component of the RND family of transporters. RND refers to Resistance, Nodulation, and cell Division. It is, in part, a subfamily of pfam00529 (Pfam release 7.5) but hits substantial numbers of proteins missed by that model. The related HlyD secretion protein, for which pfam00529 is named, is outside the scope of this model. Attributed functions imply outward transport. These functions include nodulation, acriflavin resistance, heavy metal efflux, and multidrug resistance proteins. Most members of this family are found in Gram-negative bacteria. The proposed function of MFP proteins is to bring the inner and outer membranes together and enable transport to the outside of the outer membrane. Note, however, that a few members of this family are found in Gram-positive bacteria, where there is no outer membrane. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273776 [Multi-domain] Cd Length: 322 Bit Score: 305.78 E-value: 2.38e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 36 VTVVTLKSETVGLTRELPGRTNAYLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATA 115
Cdd:TIGR01730 1 VTVATVESETLANTLTFPGSLEAVDEADLAAEVAGKITKISVREGQKVKKGQVLARLDDDDYQLALQAALAQLAAAEAQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 116 NAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQ 195
Cdd:TIGR01730 81 ELAQRSFERAERLVKRNAVSQADLDDAKAAVEAAQADLEAAKASLASAQLNLRYTEIRAPFDGTIGRRLVEVGAYVTAGQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 196 anALATVQQLDPIYVDLTQSSAELLQLRRelaagrlqdNQTLPVSILMEDGstFEHKGTLEFSEVSVDPTTGSFGLRVKV 275
Cdd:TIGR01730 161 --TLATIVDLDPLEADFSVPERDLPQLRR---------GQTLTVELDALPG--EEFKGKLRFIDPRVDSGTGTVRVRATF 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 276 DNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDtTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVI 355
Cdd:TIGR01730 228 PNPDGRLLPGMFGRVTISLKVRSSAIVVPTQAVIEDLNGK-YVYVVKNDGKVSKRPVEVGLRNGGYVEIESGLKAGDQIV 306
|
330
....*....|....*.
gi 491561842 356 VEGLQKIGPGMPVKAT 371
Cdd:TIGR01730 307 TAGVVKLRDGAKVKVV 322
|
|
| AcrA |
COG0845 |
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope ... |
40-374 |
8.11e-97 |
|
Multidrug efflux pump subunit AcrA (membrane-fusion protein) [Cell wall/membrane/envelope biogenesis, Defense mechanisms];
Pssm-ID: 440606 [Multi-domain] Cd Length: 324 Bit Score: 291.85 E-value: 8.11e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 40 TLKSETVGLTRELPGRTNAYLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATANAAR 119
Cdd:COG0845 2 KVERGDVPETVEATGTVEARREVEVRARVSGRVEEVLVDEGDRVKKGQVLARLDPPDLQAALAQAQAQLAAAQAQLELAK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 120 LSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQanAL 199
Cdd:COG0845 82 AELERYKALLKKGAVSQQELDQAKAALDQAQAALAAAQAALEQARANLAYTTIRAPFDGVVGERNVEPGQLVSAGT--PL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 200 ATVQQLDPIYVDLTQSSAELLQLRRElaagrlqdnqtLPVSILMEDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPD 279
Cdd:COG0845 160 FTIADLDPLEVEFDVPESDLARLKVG-----------QPVTVTLDAGPGKTFEGKVTFIDPAVDPATRTVRVRAELPNPD 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 280 GLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDtTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGL 359
Cdd:COG0845 229 GLLRPGMFVRVRIVLGERENALLVPASAVVRDGGGA-YVFVVDADGKVERRPVTLGRRDGDQVEVLSGLKAGDRVVVSGL 307
|
330
....*....|....*
gi 491561842 360 QKIGPGMPVKATEKG 374
Cdd:COG0845 308 QRLRDGAKVRVVEAA 322
|
|
| PRK09578 |
PRK09578 |
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit; |
4-375 |
8.35e-87 |
|
MexX/AxyX family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 169982 [Multi-domain] Cd Length: 385 Bit Score: 268.20 E-value: 8.35e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 4 SRIRPFALSLAIAAtvAACG-GQPQAPEQGPGDVTVVTLKSETVGLTRELPGRTNAYLVAEVRPQVNGIVAKRLFTEGGM 82
Cdd:PRK09578 7 RRLLLAALVALFVL--AGCGkGDSDAAAAAPREATVVTVRPTSVPMTVELPGRLDAYRQAEVRARVAGIVTARTYEEGQE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 83 VKAGEPLYQIEDASYRAQANSARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDA 162
Cdd:PRK09578 85 VKQGAVLFRIDPAPLKAARDAAAGALAKAEAAHLAALDKRRRYDDLVRDRAVSERDYTEAVADERQAKAAVASAKAELAR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 163 ANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLTQSSAELLQLRRELAAGRLQ--DNQTLPVS 240
Cdd:PRK09578 165 AQLQLDYATVTAPIDGRARRALVTEGALVGQDQATPLTTVEQLDPIYVNFSQPAADVEALRRAVKSGRATgiAQQDVAVT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 241 ILMEDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARdPKGDTTAMV 320
Cdd:PRK09578 245 LVRADGSEYPLKGKLLFSDLAVDPTTDTVAMRALFPNPERELLPGAYVRIALDRAVNPRAILVPRDALLR-TADSASVKV 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 491561842 321 VGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATEKGD 375
Cdd:PRK09578 324 VGQNGKVRDVEVEADQMSGRDWIVTRGLAGGERVIVDNAAQFAPGTAVKAVERAP 378
|
|
| CusB_dom_1 |
pfam00529 |
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ... |
45-356 |
1.62e-63 |
|
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.
Pssm-ID: 425733 [Multi-domain] Cd Length: 322 Bit Score: 206.12 E-value: 1.62e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 45 TVGLTRELPGRTNAYLVAE-VRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATANAARLSAK 123
Cdd:pfam00529 3 PLTKGVEAPGRVVVSGNAKaVQPQVSGIVTRVLVKEGDRVKAGDVLFQLDPTDYQAALDSAEAQLAKAQAQVARLQAELD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 124 RITELAKVDAVSQQDLENAVAAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQ 203
Cdd:pfam00529 83 RLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRVLAPIGGISRESLVTAGALVAQAQANLLATVA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 204 QLDPIYVDLTQSSAELLQLRRELAAGRLQDNQTLPVSILM--EDGSTFEHK----GTLEFSEVSVDPTTGSFGLRVKVDN 277
Cdd:pfam00529 163 QLDQIYVQITQSAAENQAEVRSELSGAQLQIAEAEAELKLakLDLERTEIRapvdGTVAFLSVTVDGGTVSAGLRLMFVV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 278 P-DGLLMPGMYVRAVIGGGVRSDAVLVPMQGIARDPKGDTTAMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIV 356
Cdd:pfam00529 243 PeDNLLVPGMFVETQLDQVRVGQPVLIPFDAFPQTKTGRFTGVVVGISPDTGPVRVVVDKAQGPYYPLRIGLSAGALVRL 322
|
|
| PRK11556 |
PRK11556 |
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit; |
64-372 |
3.73e-38 |
|
MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit;
Pssm-ID: 183194 [Multi-domain] Cd Length: 415 Bit Score: 141.85 E-value: 3.73e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 64 VRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATANAARLSAKRITELAKVDAVSQQDLENAV 143
Cdd:PRK11556 90 VRSRVDGQLMALHFQEGQQVKAGDLLAEIDPRPFKVALAQAQGQLAKDQATLANARRDLARYQQLAKTNLVSRQELDAQQ 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 144 AAQKQAEADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQANALATVQQLDPIYVDLT---QSSAELL 220
Cdd:PRK11556 170 ALVSETEGTIKADEASVASAQLQLDYSRITAPISGRVGLKQVDVGNQISSGDTTGIVVITQTHPIDLVFTlpeSDIATVV 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 221 QLRRelaagrlqDNQTLPVSILMEDGSTFEHKGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPGMYVRAVIGGGVRSDA 300
Cdd:PRK11556 250 QAQK--------AGKPLVVEAWDRTNSKKLSEGTLLSLDNQIDATTGTIKLKARFNNQDDALFPNQFVNARMLVDTLQNA 321
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491561842 301 VLVPMQGIARDPKGDTTaMVVGKDNKVEVRPVKVSRTVGDKWLVEDGLKAGDKVIVEGLQKIGPGMPVKATE 372
Cdd:PRK11556 322 VVIPTAALQMGNEGHFV-WVLNDENKVSKHLVTPGIQDSQKVVISAGLSAGDRVVTDGIDRLTEGAKVEVVE 392
|
|
| EmrA |
COG1566 |
Multidrug resistance efflux pump EmrA [Defense mechanisms]; |
54-292 |
3.72e-24 |
|
Multidrug resistance efflux pump EmrA [Defense mechanisms];
Pssm-ID: 441174 [Multi-domain] Cd Length: 331 Bit Score: 101.66 E-value: 3.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 54 GRTNAYLVaEVRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATANAARLSA----------- 122
Cdd:COG1566 39 GRVEARVV-TVAAKVSGRVTEVLVKEGDRVKKGQVLARLDPTDLQAALAQAEAQLAAAEAQLARLEAELgaeaeiaaaea 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 123 ----------------KRITELAKVDAVSQQDLENAVAAQKQAEADVGA---------------------------AKAS 159
Cdd:COG1566 118 qlaaaqaqldlaqrelERYQALYKKGAVSQQELDEARAALDAAQAQLEAaqaqlaqaqaglreeeelaaaqaqvaqAEAA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 160 LDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQanALATVQQLDPIYVDltqssAELlqlrRELAAGRLQDNQTLPV 239
Cdd:COG1566 198 LAQAELNLARTTIRAPVDGVVTNLNVEPGEVVSAGQ--PLLTIVPLDDLWVE-----AYV----PETDLGRVKPGQPVEV 266
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491561842 240 SILMEDGSTFEhkGTLEfsevSVDPTTGSFG--------------LRVKVDNPDGL-LMPGMYVRAVI 292
Cdd:COG1566 267 RVDAYPDRVFE--GKVT----SISPGAGFTSppknatgnvvqrypVRIRLDNPDPEpLRPGMSATVEI 328
|
|
| PRK11578 |
PRK11578 |
macrolide transporter subunit MacA; Provisional |
54-356 |
1.29e-16 |
|
macrolide transporter subunit MacA; Provisional
Pssm-ID: 183211 [Multi-domain] Cd Length: 370 Bit Score: 80.59 E-value: 1.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 54 GRTNAYLVAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQIED-------ASYRAQANSARAQLARAEATANAARLSAKRIT 126
Cdd:PRK11578 54 GKLDALRKVDVGAQVSGQLKTLSVAIGDKVKKDQLLGVIDPeqaenqiKEVEATLMELRAQRQQAEAELKLARVTLSRQQ 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 127 ELAKVDAVSQQDLENAVA--AQKQA-----EADVGAAKASLDAANVTLGYARITAPISGRIGKSSVTQGALV-SAGQANA 198
Cdd:PRK11578 134 RLAKTQAVSQQDLDTAATelAVKQAqigtiDAQIKRNQASLDTAKTNLDYTRIVAPMAGEVTQITTLQGQTViAAQQAPN 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 199 LATVQQLDPIYVDLTQSSAELLQLRRELAAGrlqdnqtlpVSILMEDGSTFEhkGTLEfsevSVDPTTGS------FGLR 272
Cdd:PRK11578 214 ILTLADMSTMLVKAQVSEADVIHLKPGQKAW---------FTVLGDPLTRYE--GVLK----DILPTPEKvndaifYYAR 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 273 VKVDNPDGLLMPGMYVRAVIGGGVRSDAVLVPMQGIArDPKGDTTAMV-VGKDNKVEVRPVKVS-RTVGDKWLVEdGLKA 350
Cdd:PRK11578 279 FEVPNPNGLLRLDMTAQVHIQLTDVKNVLTIPLSALG-DPVGDNRYKVkLLRNGETREREVTIGaRNDTDVEIVK-GLEA 356
|
....*.
gi 491561842 351 GDKVIV 356
Cdd:PRK11578 357 GDEVII 362
|
|
| HlyD_D23 |
pfam16576 |
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and ... |
51-288 |
1.49e-12 |
|
Barrel-sandwich domain of CusB or HlyD membrane-fusion; HlyD_D23 is the combined domains 2 and 3 of the membrane-fusion proteins CusB and HlyD, which forms a barrel-sandwich. CusB and HlyD proteins are membrane fusion proteins of the CusCFBA copper efflux system in E.coli and related bacteria. The whole molecule hinges between D2 and D3. Efflux systems of this resistance-nodulation-division group - RND - have been developed to excrete poisonous metal ions, and in E.coli the only one that deals with silver and copper is the CusA transporter. The transporter CusA works in conjunction with a periplasmic component that is a membrane fusion protein, eg CusB, and an outer-membrane channel component CusC in a CusABC complex driven by import of protons.
Pssm-ID: 435440 [Multi-domain] Cd Length: 214 Bit Score: 66.38 E-value: 1.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 51 ELPGR--TNAYLVAEVRPQVNGIVaKRLF--TEGGMVKAGEPLYQIedasYRAQANSARAQLaraeatanaarLSAKRIT 126
Cdd:pfam16576 7 RAVGRvaYDERRLAHVHARVEGWI-EKLYvnATGDPVKKGQPLAEL----YSPELVAAQQEY-----------LLALRSG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 127 elakvDAVSQQDLENAvAAQKQAEADVGAAK-ASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQAnaLATVQQL 205
Cdd:pfam16576 71 -----DALSKSELLRA-ARQRLRLLGMPEAQiAELERTGKVQPTVTVYAPISGVVTELNVREGMYVQPGDT--LFTIADL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 206 DPIYVDltqssAELLqlrrELAAGRLQDNQTLPVSILMEDGSTFEhkGTLEFSEVSVDPTTGSFGLRVKVDNPDGLLMPG 285
Cdd:pfam16576 143 STVWVE-----ADVP----EQDLALVKVGQPAEVTLPALPGKTFE--GKVDYIYPTLDPKTRTVRVRIELPNPDGRLKPG 211
|
...
gi 491561842 286 MYV 288
Cdd:pfam16576 212 MFA 214
|
|
| PRK03598 |
PRK03598 |
putative efflux pump membrane fusion protein; Provisional |
68-210 |
2.40e-08 |
|
putative efflux pump membrane fusion protein; Provisional
Pssm-ID: 235136 [Multi-domain] Cd Length: 331 Bit Score: 54.97 E-value: 2.40e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 68 VNGIVAKRLFTEGGMVKAGEPLYQIEDASYR-----AQAN---------------------SARAQLARAEATANAARLS 121
Cdd:PRK03598 50 VGGRLASLAVDEGDAVKAGQVLGELDAAPYEnalmqAKANvsvaqaqldlmlagyrdeeiaQARAAVKQAQAAYDYAQNF 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 122 AKRITELAKVDAVSQQDLENAVAAQKQAEA-------------------DVGAAKASLDAANVTLGYARI-------TAP 175
Cdd:PRK03598 130 YNRQQGLWKSRTISANDLENARSSRDQAQAtlksaqdklsqyregnrpqDIAQAKASLAQAQAALAQAELnlqdtelIAP 209
|
170 180 190
....*....|....*....|....*....|....*
gi 491561842 176 ISGRIGKSSVTQGALVSAGqaNALATVQQLDPIYV 210
Cdd:PRK03598 210 SDGTILTRAVEPGTMLNAG--STVFTLSLTRPVWV 242
|
|
| PRK09783 |
PRK09783 |
copper/silver efflux system membrane fusion protein CusB; Provisional |
172-359 |
7.84e-08 |
|
copper/silver efflux system membrane fusion protein CusB; Provisional
Pssm-ID: 236625 [Multi-domain] Cd Length: 409 Bit Score: 53.72 E-value: 7.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 172 ITAPISGRIGKSSVTQGALVSagQANALATVQQLDPIYVdltqsSAELlqlrRELAAGRLQDNQTLPVSILMEDGSTFE- 250
Cdd:PRK09783 212 LKAPIDGVITAFDLRAGMNIA--KDNVVAKIQGMDPVWV-----TAAI----PESIAWLVKDASQFTLTVPARPDKTFTi 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 251 HKGTLEfseVSVDPTTGSFGLRVKVDNPDGLLMPGMyvRAVIGGGVRSDA-VLVPMQGIArDPKGDTTAMVVGKDNKVEV 329
Cdd:PRK09783 281 RKWTLL---PSVDAATRTLQLRLEVDNADEALKPGM--NAWLQLNTASEPmLLIPSQALI-DTGSEQRVITVDADGRFVP 354
|
170 180 190
....*....|....*....|....*....|
gi 491561842 330 RPVKVSRTVGDKWLVEDGLKAGDKVIVEGL 359
Cdd:PRK09783 355 KRVAVFQESQGVTAIRSGLAEGEKVVSSGL 384
|
|
| HlyD_3 |
pfam13437 |
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator ... |
171-285 |
4.92e-06 |
|
HlyD family secretion protein; This is a family of largely bacterial haemolysin translocator HlyD proteins.
Pssm-ID: 433206 [Multi-domain] Cd Length: 104 Bit Score: 45.05 E-value: 4.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 171 RITAPISGRIGKSSVTQGALVSAGQanALATVQQLDPIYVDLTQSSAELLQLRRElaagrlqdnqtLPVSILMEDGSTFE 250
Cdd:pfam13437 1 TIRAPVDGVVAELNVEEGQVVQAGD--PLATIVPPDRLLVEAFVPAADLGSLKKG-----------QKVTLKLDPGSDYT 67
|
90 100 110
....*....|....*....|....*....|....*..
gi 491561842 251 HKGTLEFSEVSVDPTTGSFGLRVKVDNPDG--LLMPG 285
Cdd:pfam13437 68 LEGKVVRISPTVDPDTGVIPVRVSIENPKTpiPLLPG 104
|
|
| PRK10476 |
PRK10476 |
multidrug transporter subunit MdtN; |
53-196 |
1.65e-04 |
|
multidrug transporter subunit MdtN;
Pssm-ID: 182488 [Multi-domain] Cd Length: 346 Bit Score: 43.48 E-value: 1.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 53 PGRTNAYLVAE---VRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQLARAEATANAAR--LSAK---- 123
Cdd:PRK10476 37 PSTDDAYIDADvvhVASEVGGRIVELAVTENQAVKKGDLLFRIDPRPYELTVAQAQADLALADAQIMTTQrsVDAErsna 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491561842 124 ----------------------RITELAKVDAVSQQDLENAVAAQKQAEAD------------------------VGAAK 157
Cdd:PRK10476 117 asaneqveraranaklatrtleRLEPLLAKGYVSAQQVDQARTAQRDAEVSlnqallqaqaaaaavggvdalvaqRAARE 196
|
170 180 190
....*....|....*....|....*....|....*....
gi 491561842 158 ASLDAANVTLGYARITAPISGRIGKSSVTQGALVSAGQA 196
Cdd:PRK10476 197 AALAIAELHLEDTTVRAPFDGRVVGLKVSVGEFAAPMQP 235
|
|
| Biotin_lipoyl_2 |
pfam13533 |
Biotin-lipoyl like; |
61-108 |
1.73e-04 |
|
Biotin-lipoyl like;
Pssm-ID: 433286 Cd Length: 50 Bit Score: 38.96 E-value: 1.73e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 491561842 61 VAEVRPQVNGIVAKRLFTEGGMVKAGEPLYQIEDASYRAQANSARAQL 108
Cdd:pfam13533 2 VVKIASPVSGKVVAVNVKEGQQVKKGDVLATLDSPELQLQLQQAEAQL 49
|
|
| |
