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Conserved domains on  [gi|491574196|ref|WP_005431775|]
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lysozyme [Sutterella wadsworthensis]

Protein Classification

lysozyme( domain architecture ID 10091405)

lysozyme, also called endolysin or muramidase, hydrolyzes (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins; similar to Salmonella virus P22 endolysin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 13-146 9.67e-64

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


:

Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 191.19  E-value: 9.67e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196  13 AVPLVIEYEGFRSKAYLCPAGVWTIGYGHTGGV--HPDDRIDMENARHVLASDLQDVQNRLIEYLNVSVTSGQFIALISL 90
Cdd:cd00737    1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVvvKPGDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALVSF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491574196  91 AFNVGVRAVSMSKLLRKLNEGDEEGAADEFLDWTKAGGKELAGLVKRRREEREYFL 146
Cdd:cd00737   81 AFNVGAGAFKSSTLLRKLNAGDYAGAADEFLRWNKAGGKVLPGLVRRRAAEAALFL 136
 
Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 13-146 9.67e-64

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 191.19  E-value: 9.67e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196  13 AVPLVIEYEGFRSKAYLCPAGVWTIGYGHTGGV--HPDDRIDMENARHVLASDLQDVQNRLIEYLNVSVTSGQFIALISL 90
Cdd:cd00737    1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVvvKPGDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALVSF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491574196  91 AFNVGVRAVSMSKLLRKLNEGDEEGAADEFLDWTKAGGKELAGLVKRRREEREYFL 146
Cdd:cd00737   81 AFNVGAGAFKSSTLLRKLNAGDYAGAADEFLRWNKAGGKVLPGLVRRRAAEAALFL 136
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
10-148 1.32e-59

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 181.19  E-value: 1.32e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196  10 PDLAVPLVIEYEGFRSKAYLCPAGVWTIGYGHTG-GVHPDDRIDMENARHVLASDLQDVQNRLIEYLNVSVTSGQFIALI 88
Cdd:COG3772    5 SAAGLALIKEFEGFRLKAYRDPAGVWTIGYGHTGkDVKPGDTITEEEAEALLAADLAKAEAAVRRLVKVPLTQNQFDALV 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196  89 SLAFNVGVRAVSMSKLLRKLNEGDEEGAADEFLDWTKAGGKELAGLVKRRREEREYFLRG 148
Cdd:COG3772   85 SFAYNVGAGAFCRSTLLRKLNAGDYAGACDELLRWVYAGGKVLPGLVRRREAERALCLGG 144
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 34-139 7.97e-18

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 73.54  E-value: 7.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196   34 VWTIGYGHTG-GVHPDDRIDMENARHVLASDLQDVQNRLIEYLNV-SVTSGQFIALISLAFNVGVRAVSMSKLLRKLNEG 111
Cdd:pfam00959   1 YWTIGIGHNGkDVSPHPRATKSEAAGRLQIDLDTAERCINQYHKVkDFNPNQQDALVSLAFNVGCGKRGFSTLLRAGNIG 80

                          90       100
                  ....*....|....*....|....*...
gi 491574196  112 DEEGAADEFLDWTKAgGKELAGLVKRRR 139
Cdd:pfam00959  81 QWIKACSAIWKSLKA-GKVYNGLVNRRE 107
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 6-122 1.52e-05

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 43.59  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196   6 GEYPPDLAVPLVIEY-----EGFRSKAYLCPAGVWTIGYGH-------------------------TGGvhpddRIDMEN 55
Cdd:PHA02596 163 DEIPPDDNPDFTIEKmlrrdEGIRLKVYWDSEGYPTIGIGHliirektrdmaqinkllskqvgrevTGG-----RITAEE 237

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491574196  56 ARHVLASDLQDVQNRLIEYLNVS-----VTSGQFIALISLAFNVGVRAVS-MSKLLRKLNEGDEEGAADEFLD 122
Cdd:PHA02596 238 ASKLFARDLAKVQRDISRHSKVGpvynkLNRSRQMALENMAFQMGVGGVAkFKNMLAAMLAGDWKKAYDALRD 310
 
Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 13-146 9.67e-64

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 191.19  E-value: 9.67e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196  13 AVPLVIEYEGFRSKAYLCPAGVWTIGYGHTGGV--HPDDRIDMENARHVLASDLQDVQNRLIEYLNVSVTSGQFIALISL 90
Cdd:cd00737    1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVvvKPGDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALVSF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491574196  91 AFNVGVRAVSMSKLLRKLNEGDEEGAADEFLDWTKAGGKELAGLVKRRREEREYFL 146
Cdd:cd00737   81 AFNVGAGAFKSSTLLRKLNAGDYAGAADEFLRWNKAGGKVLPGLVRRRAAEAALFL 136
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
10-148 1.32e-59

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 181.19  E-value: 1.32e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196  10 PDLAVPLVIEYEGFRSKAYLCPAGVWTIGYGHTG-GVHPDDRIDMENARHVLASDLQDVQNRLIEYLNVSVTSGQFIALI 88
Cdd:COG3772    5 SAAGLALIKEFEGFRLKAYRDPAGVWTIGYGHTGkDVKPGDTITEEEAEALLAADLAKAEAAVRRLVKVPLTQNQFDALV 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196  89 SLAFNVGVRAVSMSKLLRKLNEGDEEGAADEFLDWTKAGGKELAGLVKRRREEREYFLRG 148
Cdd:COG3772   85 SFAYNVGAGAFCRSTLLRKLNAGDYAGACDELLRWVYAGGKVLPGLVRRREAERALCLGG 144
lyz_P1 cd16901
P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the ...
 16-143 1.20e-43

P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the Escherichia coli periplasm where it is membrane bound and inactive. Activation involves the release from the membrane, an intramolecular thiol-disulfide isomerization and extensive structural rearrangement of the N-terminal region. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381620 [Multi-domain]  Cd Length: 140  Bit Score: 140.43  E-value: 1.20e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196  16 LVIEYEGFRSKAYLCPAGVWTIGYGHTGGVHPDDRIDMENARHVLASDLQDVQNRLIEYLN-VSVTSGQFIALISLAFNV 94
Cdd:cd16901    9 LIANAEGCRRDPYKCPAGVPTIGIGSTHGVKPGDRYTDEQAAKRLAKDIKKAERCVNRCFNgVPLPQGEFDAYVSFAFNV 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 491574196  95 GVRAVSMSKLLRKLNEGDEEGAADEFLDWTKAGGKELAGLVKRRREERE 143
Cdd:cd16901   89 GCGAFCKSTIYKKLQAGDYAAACNQLPRWVYAGGKVLPGLVTRRQKERA 137
endolysin_R21-like cd16900
endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria ...
 13-146 2.86e-40

endolysin R21-like proteins; Unlike T4 E phage lysozyme, the endolysin R21 from Enterobacteria phage P21 has an N-terminal SAR (signal-arrest-release) domain that anchors the endolysin to the membrane in an inactive form, which act to prevent premature lysis of the infected bacterium. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381619 [Multi-domain]  Cd Length: 142  Bit Score: 131.91  E-value: 2.86e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196  13 AVPLVIEYEGFRSKAYLCPAGVWTIGYGHTGG-VHPDDRIDMENARHVLASDLQDVQNRLIEYLNVSVTSGQFIALISLA 91
Cdd:cd16900    8 AAALVGPWEGLRLTAYRDPVGVWTVCYGHTGGdVKPGMRYTPAECDALLAKDLQEAAAAVDRCVKVPLPDPQRAALASFA 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 491574196  92 FNVGVRAVSMSKLLRKLNEGDEEGAADEFLDWTKAGGKELAGLVKRRREEREYFL 146
Cdd:cd16900   88 YNVGVGAFCRSTLLRKLNAGDRRGACDELTRWVYAGGRVLRGLVNRREAERALCL 142
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 34-139 7.97e-18

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 73.54  E-value: 7.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196   34 VWTIGYGHTG-GVHPDDRIDMENARHVLASDLQDVQNRLIEYLNV-SVTSGQFIALISLAFNVGVRAVSMSKLLRKLNEG 111
Cdd:pfam00959   1 YWTIGIGHNGkDVSPHPRATKSEAAGRLQIDLDTAERCINQYHKVkDFNPNQQDALVSLAFNVGCGKRGFSTLLRAGNIG 80

                          90       100
                  ....*....|....*....|....*...
gi 491574196  112 DEEGAADEFLDWTKAgGKELAGLVKRRR 139
Cdd:pfam00959  81 QWIKACSAIWKSLKA-GKVYNGLVNRRE 107
T4-like_lys cd00735
bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1, ...
 14-140 2.83e-11

bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan heteropolymers of prokaryotic cell walls. Members include a variety of bacteriophages (T4, RB49, RB69, Aeh1), as well as Dictyostelium.


Pssm-ID: 381597  Cd Length: 146  Bit Score: 57.77  E-value: 2.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196  14 VPLVIEYEGFRSKAYLCPAGVWTIGYGHTGGVHPDD----RIDMENARHVLASDLQDVQ-----NRLIEYLNVSVTSGQF 84
Cdd:cd00735    3 REMLRQDEGYRLKAYKDTEGYPTIGIGHLIGKKGASltngTITKDEAEALFEQDVDRAVrdmlrNPKLAPVYAQLNAARR 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491574196  85 IALISLAFNVGVRAVS-MSKLLRKLNEGDEEGAADEFLDWTkaGGKELAGLVKRRRE 140
Cdd:cd00735   83 MALINMAFQMGVGGLAkFKNMLAAIKAGDWEEAADGMLNSL--WAKQTPNRANRVSA 137
5 PHA02596
baseplate hub subunit and tail lysozyme; Provisional
 6-122 1.52e-05

baseplate hub subunit and tail lysozyme; Provisional


Pssm-ID: 222900 [Multi-domain]  Cd Length: 576  Bit Score: 43.59  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491574196   6 GEYPPDLAVPLVIEY-----EGFRSKAYLCPAGVWTIGYGH-------------------------TGGvhpddRIDMEN 55
Cdd:PHA02596 163 DEIPPDDNPDFTIEKmlrrdEGIRLKVYWDSEGYPTIGIGHliirektrdmaqinkllskqvgrevTGG-----RITAEE 237

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491574196  56 ARHVLASDLQDVQNRLIEYLNVS-----VTSGQFIALISLAFNVGVRAVS-MSKLLRKLNEGDEEGAADEFLD 122
Cdd:PHA02596 238 ASKLFARDLAKVQRDISRHSKVGpvynkLNRSRQMALENMAFQMGVGGVAkFKNMLAAMLAGDWKKAYDALRD 310
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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