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Conserved domains on  [gi|491590951|ref|WP_005448516|]
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MULTISPECIES: bifunctional GNAT family N-acetyltransferase/hotdog fold thioesterase [Vibrio]

Protein Classification

bifunctional GNAT family N-acetyltransferase/hotdog fold thioesterase( domain architecture ID 10456982)

bifunctional GNAT family N-acetyltransferase/hotdog fold thioesterase containing an N-terminal domain that may catalyze the transfer of an acetyl group from acetyl-CoA to a substrate and a C-terminal thioesterase domain, similar to Escherichia coli putative acetyltransferase YiiD

CATH:  3.10.129.10
EC:  2.3.1.-|3.1.2.-
Gene Ontology:  GO:0008080
PubMed:  10940244|9175471|15307895
SCOP:  3000149|3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YiiD_C pfam09500
Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed ...
 157-297 7.25e-77

Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed uncharacterized domain often found as a standalone protein. The member from Shewanella oneidensis is described from crystallography work as a putative thioesterase because it belongs to the HotDog clan of enzymes. About half of the members of this family are fused to an Acetyltransf_1 domain pfam00583.


:

Pssm-ID: 430649  Cd Length: 144  Bit Score: 230.99  E-value: 7.25e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  157 CTELQQRWEAQIPIADKMGIKINQYTGYQFECSAQLNPNLNPHNTMFAGSAFTLATLTGWGMTWLLMKERGLHGDIVLAD 236
Cdd:pfam09500   1 CQELQETWHDHIPLSRAMGIKVTQYDGQEFILSAPLAPNINHHGTMFAGSIYTLATLTGWGLLWLLLKEAGLEGDIVLAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491590951  237 SSIRYRHPVEENPVASTSL---DGISGDLDRLASGRKARIVIHVVIYSGDVPAVDFVGTYMLLP 297
Cdd:pfam09500  81 GNIRYLKPVTGDPTARVSLptpEAWSGFLSRLARGGKARITLEVEIYSGGELAAEFTGRYVVLK 144
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
10-145 2.86e-37

Predicted N-acyltransferase, GNAT family [General function prediction only];


:

Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 129.15  E-value: 2.86e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  10 ENQLNKYYQFRWQLLREPWRMPVGSERDEYDGMSHHRMITDSrGRPMAIGRLYITPDNDGQIRYMAVKNNRRSKGMGSLV 89
Cdd:COG2153    1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDD-GELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491590951  90 LVALESLARQEGAKRLVCNAREDAIAFYEKNGFERRGELTDERGpVRHQQMVKQLD 145
Cdd:COG2153   80 MEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAG-IPHIDMRKPLS 134
 
Name Accession Description Interval E-value
YiiD_C pfam09500
Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed ...
 157-297 7.25e-77

Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed uncharacterized domain often found as a standalone protein. The member from Shewanella oneidensis is described from crystallography work as a putative thioesterase because it belongs to the HotDog clan of enzymes. About half of the members of this family are fused to an Acetyltransf_1 domain pfam00583.


Pssm-ID: 430649  Cd Length: 144  Bit Score: 230.99  E-value: 7.25e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  157 CTELQQRWEAQIPIADKMGIKINQYTGYQFECSAQLNPNLNPHNTMFAGSAFTLATLTGWGMTWLLMKERGLHGDIVLAD 236
Cdd:pfam09500   1 CQELQETWHDHIPLSRAMGIKVTQYDGQEFILSAPLAPNINHHGTMFAGSIYTLATLTGWGLLWLLLKEAGLEGDIVLAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491590951  237 SSIRYRHPVEENPVASTSL---DGISGDLDRLASGRKARIVIHVVIYSGDVPAVDFVGTYMLLP 297
Cdd:pfam09500  81 GNIRYLKPVTGDPTARVSLptpEAWSGFLSRLARGGKARITLEVEIYSGGELAAEFTGRYVVLK 144
yiiD_Cterm TIGR02447
thioesterase domain, putative; This family consists of a broadly distributed uncharacterized ...
 164-297 1.07e-54

thioesterase domain, putative; This family consists of a broadly distributed uncharacterized domain found often as a standalone protein. The member from Shewanella oneidensis, PDB|1T82_A (Forouhar, et al., unpublished) is described from crystallography work as a putative thioesterase. About half of the members of this family are fused to an Acetyltransf_1 domain (pfam00583). The function of this protein is unknown.


Pssm-ID: 131500  Cd Length: 138  Bit Score: 174.46  E-value: 1.07e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  164 WEAQIPIADKMGIKINQYTGYQFECSAQLNPNLNPHNTMFAGSAFTLATLTGWGMTWLLMKERGLHGDIVLADSSIRYRH 243
Cdd:TIGR02447   2 LHSAIPLSEAMGIAVSSYTGGELRLSAPLAANINHHGTMFGGSLYTLATLSGWGLLWLRLQELGIDGDIVIADSHIRYLA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491590951  244 PVEENPVAST---SLDGISGDLDRLASGRKARIVIHVVIYSGDVPAVDFVGTYMLLP 297
Cdd:TIGR02447  82 PVTGDPVANCeapDLESWEAFLATLQRGGKARVKLEAQISSDGKLAATFSGEYVALP 138
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
10-145 2.86e-37

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 129.15  E-value: 2.86e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  10 ENQLNKYYQFRWQLLREPWRMPVGSERDEYDGMSHHRMITDSrGRPMAIGRLYITPDNDGQIRYMAVKNNRRSKGMGSLV 89
Cdd:COG2153    1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDD-GELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491590951  90 LVALESLARQEGAKRLVCNAREDAIAFYEKNGFERRGELTDERGpVRHQQMVKQLD 145
Cdd:COG2153   80 MEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAG-IPHIDMRKPLS 134
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 13-122 1.13e-09

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 55.22  E-value: 1.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951   13 LNKYYQFRWQLLREPWRMPVGSERDEYDGMSHHRMITDSR-GRPMAIGRLYITPDND--GQIRYMAVKNNRRSKGMGSLV 89
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEdGELVGFASLSIIDDEPpvGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 491590951   90 LVALESLARQEGAKRLVCNARED---AIAFYEKNGF 122
Cdd:pfam00583  81 LQALLEWARERGCERIFLEVAADnlaAIALYEKLGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 63-128 4.03e-05

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 42.70  E-value: 4.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491590951   63 ITPDNdGQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNARED---AIAFYEKNGFERRGEL 128
Cdd:TIGR01575  50 IVLDE-AHILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSniaAQALYKKLGFNEIAIR 117
PTZ00330 PTZ00330
acetyltransferase; Provisional
 69-125 4.15e-05

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 42.91  E-value: 4.15e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491590951  69 GQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNAREDAIAFYEKNGFERR 125
Cdd:PTZ00330  83 GHIEDVVVDPSYRGQGLGRALISDLCEIARSSGCYKVILDCTEDMVAFYKKLGFRAC 139
PaaI COG2050
Acyl-CoA thioesterase PaaI, contains HGG motif [Secondary metabolites biosynthesis, transport ...
 162-297 7.30e-05

Acyl-CoA thioesterase PaaI, contains HGG motif [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441653 [Multi-domain]  Cd Length: 138  Bit Score: 41.85  E-value: 7.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951 162 QRWEAQIPIADKMGIKINQYTGYQFECSAQLNP-NLNPHNTMFAGSAFTLATLTgwgMTWLLMKERGLHGDIVLADSSIR 240
Cdd:COG2050    9 EGFLAANPFAELLGIELVEVEPGRAVLRLPVRPeHLNPPGTVHGGALAALADSA---AGLAANSALPPGRRAVTIELNIN 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491590951 241 YRHPVEENPVAStsldgISGDLDRLasGRKaRIVIHVVIYSGD-VPAVDFVGTYMLLP 297
Cdd:COG2050   86 FLRPARLGDRLT-----AEARVVRR--GRR-LAVVEVEVTDEDgKLVATATGTFAVLP 135
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 53-108 2.84e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 35.71  E-value: 2.84e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491590951  53 GRPMAIGRLYITPDND--GQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCN 108
Cdd:cd04301    8 GEIVGFASLSPDGSGGdtAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
 
Name Accession Description Interval E-value
YiiD_C pfam09500
Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed ...
 157-297 7.25e-77

Putative thioesterase (yiiD_Cterm); This entry consists of a broadly distributed uncharacterized domain often found as a standalone protein. The member from Shewanella oneidensis is described from crystallography work as a putative thioesterase because it belongs to the HotDog clan of enzymes. About half of the members of this family are fused to an Acetyltransf_1 domain pfam00583.


Pssm-ID: 430649  Cd Length: 144  Bit Score: 230.99  E-value: 7.25e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  157 CTELQQRWEAQIPIADKMGIKINQYTGYQFECSAQLNPNLNPHNTMFAGSAFTLATLTGWGMTWLLMKERGLHGDIVLAD 236
Cdd:pfam09500   1 CQELQETWHDHIPLSRAMGIKVTQYDGQEFILSAPLAPNINHHGTMFAGSIYTLATLTGWGLLWLLLKEAGLEGDIVLAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491590951  237 SSIRYRHPVEENPVASTSL---DGISGDLDRLASGRKARIVIHVVIYSGDVPAVDFVGTYMLLP 297
Cdd:pfam09500  81 GNIRYLKPVTGDPTARVSLptpEAWSGFLSRLARGGKARITLEVEIYSGGELAAEFTGRYVVLK 144
yiiD_Cterm TIGR02447
thioesterase domain, putative; This family consists of a broadly distributed uncharacterized ...
 164-297 1.07e-54

thioesterase domain, putative; This family consists of a broadly distributed uncharacterized domain found often as a standalone protein. The member from Shewanella oneidensis, PDB|1T82_A (Forouhar, et al., unpublished) is described from crystallography work as a putative thioesterase. About half of the members of this family are fused to an Acetyltransf_1 domain (pfam00583). The function of this protein is unknown.


Pssm-ID: 131500  Cd Length: 138  Bit Score: 174.46  E-value: 1.07e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  164 WEAQIPIADKMGIKINQYTGYQFECSAQLNPNLNPHNTMFAGSAFTLATLTGWGMTWLLMKERGLHGDIVLADSSIRYRH 243
Cdd:TIGR02447   2 LHSAIPLSEAMGIAVSSYTGGELRLSAPLAANINHHGTMFGGSLYTLATLSGWGLLWLRLQELGIDGDIVIADSHIRYLA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 491590951  244 PVEENPVAST---SLDGISGDLDRLASGRKARIVIHVVIYSGDVPAVDFVGTYMLLP 297
Cdd:TIGR02447  82 PVTGDPVANCeapDLESWEAFLATLQRGGKARVKLEAQISSDGKLAATFSGEYVALP 138
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
10-145 2.86e-37

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 129.15  E-value: 2.86e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  10 ENQLNKYYQFRWQLLREPWRMPVGSERDEYDGMSHHRMITDSrGRPMAIGRLYITPDNDGQIRYMAVKNNRRSKGMGSLV 89
Cdd:COG2153    1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDD-GELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491590951  90 LVALESLARQEGAKRLVCNAREDAIAFYEKNGFERRGELTDERGpVRHQQMVKQLD 145
Cdd:COG2153   80 MEAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAG-IPHIDMRKPLS 134
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 53-145 6.19e-16

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 73.10  E-value: 6.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  53 GRPMAIGRLYITPDNDGQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNAREDAIAFYEKNGFER--RGELTD 130
Cdd:COG1246   37 GEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAAIHFYEKLGFEEidKEDLPY 116

                         90
                 ....*....|....*.
gi 491590951 131 ERGPVRHQ-QMVKQLD 145
Cdd:COG1246  117 AKVWQRDSvVMEKDLE 132
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 52-146 2.89e-12

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 62.76  E-value: 2.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  52 RGRPMAIGRLYITPDNDGQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRL---VCNAREDAIAFYEKNGFERRGEL 128
Cdd:COG0454   42 KGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTALeldTLDGNPAAIRFYERLGFKEIERY 121

                         90
                 ....*....|....*...
gi 491590951 129 TDERGPvrhqQMVKQLDP 146
Cdd:COG0454  122 VAYVGG----EFEKELSL 135
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 62-145 4.77e-11

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 58.13  E-value: 4.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  62 YITPDNDGQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNARED---AIAFYEKNGFERRGELTDERGPVRHq 138
Cdd:COG0456    7 LVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDneaAIALYEKLGFEEVGERPNYYGDDAL- 85


                 ....*..
gi 491590951 139 QMVKQLD 145
Cdd:COG0456   86 VMEKELA 92
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 13-122 1.13e-09

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 55.22  E-value: 1.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951   13 LNKYYQFRWQLLREPWRMPVGSERDEYDGMSHHRMITDSR-GRPMAIGRLYITPDND--GQIRYMAVKNNRRSKGMGSLV 89
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEdGELVGFASLSIIDDEPpvGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 491590951   90 LVALESLARQEGAKRLVCNARED---AIAFYEKNGF 122
Cdd:pfam00583  81 LQALLEWARERGCERIFLEVAADnlaAIALYEKLGF 116
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
54-129 1.19e-09

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 54.14  E-value: 1.19e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491590951  54 RPMAIGRLYITPDNDGQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNARED---AIAFYEKNGFERRGELT 129
Cdd:COG3393    1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADnpaARRLYERLGFRPVGEYA 79
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 53-124 1.66e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 53.61  E-value: 1.66e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491590951   53 GRPMAIGRLYITPDNDGQIR-YMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNAREDAIAFYEKNGFER 124
Cdd:pfam13508  12 GKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKLGFEE 84
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
69-144 2.33e-09

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 55.09  E-value: 2.33e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491590951  69 GQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNAREDAIAFYEKNGFERRGELTDERGPVRHqQMVKQL 144
Cdd:COG3153   68 LLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFGFRPAGELGLTLGPDEV-FLAKEL 142
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
76-130 1.59e-06

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 47.30  E-value: 1.59e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491590951  76 VKNNRRSKGMGSLVLVALESLARQEGAKRL---VCNAREDAIAFYEKNGFERRGELTD 130
Cdd:COG1247   88 VDPDARGRGIGRALLEALIERARARGYRRLvavVLADNEASIALYEKLGFEEVGTLPE 145
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 62-144 2.68e-05

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 43.03  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951   62 YITPDNDGQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAK--RLVCNAREDAIAFYEKNGFERRGELTDERGpVRHQQ 139
Cdd:pfam13673  45 VIALRDRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKlsELTVNASPYAVPFYEKLGFRATGPEQEFNG-IRFVP 123


                  ....*
gi 491590951  140 MVKQL 144
Cdd:pfam13673 124 MEKEL 128
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 63-128 4.03e-05

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 42.70  E-value: 4.03e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491590951   63 ITPDNdGQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNARED---AIAFYEKNGFERRGEL 128
Cdd:TIGR01575  50 IVLDE-AHILNIAVKPEYQGQGIGRALLRELIDEAKGRGVNEIFLEVRVSniaAQALYKKLGFNEIAIR 117
PTZ00330 PTZ00330
acetyltransferase; Provisional
 69-125 4.15e-05

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 42.91  E-value: 4.15e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491590951  69 GQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNAREDAIAFYEKNGFERR 125
Cdd:PTZ00330  83 GHIEDVVVDPSYRGQGLGRALISDLCEIARSSGCYKVILDCTEDMVAFYKKLGFRAC 139
PaaI COG2050
Acyl-CoA thioesterase PaaI, contains HGG motif [Secondary metabolites biosynthesis, transport ...
 162-297 7.30e-05

Acyl-CoA thioesterase PaaI, contains HGG motif [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441653 [Multi-domain]  Cd Length: 138  Bit Score: 41.85  E-value: 7.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951 162 QRWEAQIPIADKMGIKINQYTGYQFECSAQLNP-NLNPHNTMFAGSAFTLATLTgwgMTWLLMKERGLHGDIVLADSSIR 240
Cdd:COG2050    9 EGFLAANPFAELLGIELVEVEPGRAVLRLPVRPeHLNPPGTVHGGALAALADSA---AGLAANSALPPGRRAVTIELNIN 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491590951 241 YRHPVEENPVAStsldgISGDLDRLasGRKaRIVIHVVIYSGD-VPAVDFVGTYMLLP 297
Cdd:COG2050   86 FLRPARLGDRLT-----AEARVVRR--GRR-LAVVEVEVTDEDgKLVATATGTFAVLP 135
PLN02706 PLN02706
glucosamine 6-phosphate N-acetyltransferase
 69-126 8.09e-04

glucosamine 6-phosphate N-acetyltransferase


Pssm-ID: 178308 [Multi-domain]  Cd Length: 150  Bit Score: 39.30  E-value: 8.09e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491590951  69 GQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNAREDAIAFYEKNGFERRG 126
Cdd:PLN02706  86 GHIEDVVVDSAARGKGLGKKIIEALTEHARSAGCYKVILDCSEENKAFYEKCGYVRKE 143
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 53-108 2.84e-03

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 35.71  E-value: 2.84e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491590951  53 GRPMAIGRLYITPDND--GQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCN 108
Cdd:cd04301    8 GEIVGFASLSPDGSGGdtAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PRK07922 PRK07922
amino-acid N-acetyltransferase;
69-123 5.53e-03

amino-acid N-acetyltransferase;


Pssm-ID: 236132 [Multi-domain]  Cd Length: 169  Bit Score: 36.82  E-value: 5.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 491590951  69 GQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNAREdaIAFYEKNGFE 123
Cdd:PRK07922  71 AEIRTVAVDPAARGRGVGHAIVERLLDVARELGLSRVFVLTFE--VEFFARHGFV 123
PRK07757 PRK07757
N-acetyltransferase;
53-124 6.00e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 36.71  E-value: 6.00e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491590951  53 GRPMAIGRLYITPDNDGQIRYMAVKNNRRSKGMGSLVLVALESLARQEGAKRLVCNAREDaiAFYEKNGFER 124
Cdd:PRK07757  50 GEIVGCCALHILWEDLAEIRSLAVSEDYRGQGIGRMLVEACLEEARELGVKRVFALTYQP--EFFEKLGFRE 119
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 36-130 7.63e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 36.52  E-value: 7.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491590951  36 RDEYDGMSHHRMITD-SRGRPMAIGRLYITPDNDGQ--IRYMaVKNNRRSKGMGSLVLVALESLARQE-GAKRLVCNARE 111
Cdd:COG1670   53 ADWADGGALPFAIEDkEDGELIGVVGLYDIDRANRSaeIGYW-LAPAYWGKGYATEALRALLDYAFEElGLHRVEAEVDP 131

                         90       100
                 ....*....|....*....|..
gi 491590951 112 D---AIAFYEKNGFERRGELTD 130
Cdd:COG1670  132 DntaSIRVLEKLGFRLEGTLRD 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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