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Conserved domains on  [gi|491592855|ref|WP_005450420|]
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MULTISPECIES: alpha/beta fold hydrolase [Vibrio]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 4-269 1.84e-46

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 154.77  E-value: 1.84e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   4 FEIEGQQLAYLDKG-EGPVLLFGHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGESDAaPASTRSLVDYAQHMLALMDH 82
Cdd:COG0596    7 VTVDGVRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDK-PAGGYTLDDLADDLAALLDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  83 LEIEQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDtfiglepevthkkyfamldaisqvqavpapiveavtplffanna 162
Cdd:COG0596   86 LGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD-------------------------------------------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855 163 eqanpELVASFKQSLEALQGERAVEVARIGRMVfgRRDVIEDAEMFALPTLIAVGREDKPRPVFESYLMNDCITGSELVE 242
Cdd:COG0596  122 -----EVLAALAEPLRRPGLAPEALAALLRALA--RTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVV 194

                        250       260
                 ....*....|....*....|....*..
gi 491592855 243 IPEAGHISSLEQPEIVNQMLLDFLNKV 269
Cdd:COG0596  195 LPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 4-269 1.84e-46

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 154.77  E-value: 1.84e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   4 FEIEGQQLAYLDKG-EGPVLLFGHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGESDAaPASTRSLVDYAQHMLALMDH 82
Cdd:COG0596    7 VTVDGVRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDK-PAGGYTLDDLADDLAALLDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  83 LEIEQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDtfiglepevthkkyfamldaisqvqavpapiveavtplffanna 162
Cdd:COG0596   86 LGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD-------------------------------------------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855 163 eqanpELVASFKQSLEALQGERAVEVARIGRMVfgRRDVIEDAEMFALPTLIAVGREDKPRPVFESYLMNDCITGSELVE 242
Cdd:COG0596  122 -----EVLAALAEPLRRPGLAPEALAALLRALA--RTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVV 194

                        250       260
                 ....*....|....*....|....*..
gi 491592855 243 IPEAGHISSLEQPEIVNQMLLDFLNKV 269
Cdd:COG0596  195 LPGAGHFPPLEQPEAFAAALRDFLARL 221
protocat_pcaD TIGR02427
3-oxoadipate enol-lactonase; Members of this family are 3-oxoadipate enol-lactonase. Note that ...
 20-266 1.36e-37

3-oxoadipate enol-lactonase; Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other]


Pssm-ID: 131480 [Multi-domain]  Cd Length: 251  Bit Score: 132.87  E-value: 1.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   20 PVLLFGHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGESDAaPASTRSLVDYAQHMLALMDHLEIEQFSIVGLSVGGMW 99
Cdd:TIGR02427  14 PVLVFINSLGTDLRMWDPVLPALTPDFRVLRYDKRGHGLSDA-PEGPYSIEDLADDVLALLDHLGIERAVFCGLSLGGLI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  100 GAELTSQAPQRVKSLVLMDTF--IGlepevTHKKYFAMLDAISQvQAVPApIVEAVTPLFFANNAEQANPELVASFKQSL 177
Cdd:TIGR02427  93 AQGLAARRPDRVRALVLSNTAakIG-----TPESWNARIAAVRA-EGLAA-LADAVLERWFTPGFREAHPARLDLYRNML 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  178 EA--LQGeRAVEVARIGRMvfgrrDVIEDAEMFALPTLIAVGREDKPRPVFESYLMNDCITGSELVEIPEAGHISSLEQP 255
Cdd:TIGR02427 166 VRqpPDG-YAGCCAAIRDA-----DFRDRLGAIAVPTLCIAGDQDGSTPPELVREIADLVPGARFAEIRGAGHIPCVEQP 239

                         250
                  ....*....|.
gi 491592855  256 EIVNQMLLDFL 266
Cdd:TIGR02427 240 EAFNAALRDFL 250
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 5-269 4.07e-22

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 94.24  E-value: 4.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   5 EIEGQQLAYLDKGEG---PVLLFgHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGESDAAPASTrSLVDYAQHMLALMD 81
Cdd:PRK14875 115 RIGGRTVRYLRLGEGdgtPVVLI-HGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASSKAVGAG-SLDELAAAVLAFLD 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  82 HLEIEQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDTfIGLEPEVTHKKYFAMLDAISQVQAVPapiveAVTPLFfann 161
Cdd:PRK14875 193 ALGIERAHLVGHSMGGAVALRLAARAPQRVASLTLIAP-AGLGPEINGDYIDGFVAAESRRELKP-----VLELLF---- 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855 162 aeqANPELVAsfKQSLEALQGERAVEVAR-----IGRMVFG----RRDVIEDAEMFALPTLIAVGREDKPRPVFESYLMN 232
Cdd:PRK14875 263 ---ADPALVT--RQMVEDLLKYKRLDGVDdalraLADALFAggrqRVDLRDRLASLAIPVLVIWGEQDRIIPAAHAQGLP 337

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 491592855 233 DcitGSELVEIPEAGHISSLEQPEIVNQMLLDFLNKV 269
Cdd:PRK14875 338 D---GVAVHVLPGAGHMPQMEAAADVNRLLAEFLGKA 371
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 20-255 8.15e-21

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 88.33  E-value: 8.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   20 PVLLFGHSYLWDNQMWAPQIEVLSQS-YRCIVPDLWAHGESDAAPASTR-SLVDYAQHMLALMDHLEIEQFSIVGLSVGG 97
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKSSRPKAQDDyRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   98 MWGAELTSQAPQRVKSLVLMDT-----FIGLEPEVTHKKYFAMLDAISQVQAVP--APIVEA-VTPLFFANNAEQANPEL 169
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGAldpphELDEADRFILALFPGFFDGFVADFAPNplGRLVAKlLALLLLRLRLLKALPLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  170 VASFKqslealQGERAVEVARIGRMVFGRRDVIEDAEMFAL-----PTLIAVGREDKPRPVFESYLMNDCITGSELVEIP 244
Cdd:pfam00561 161 NKRFP------SGDYALAKSLVTGALLFIETWSTELRAKFLgrldePTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIP 234

                         250
                  ....*....|.
gi 491592855  245 EAGHISSLEQP 255
Cdd:pfam00561 235 DAGHFAFLEGP 245
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 4-269 1.84e-46

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 154.77  E-value: 1.84e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   4 FEIEGQQLAYLDKG-EGPVLLFGHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGESDAaPASTRSLVDYAQHMLALMDH 82
Cdd:COG0596    7 VTVDGVRLHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDK-PAGGYTLDDLADDLAALLDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  83 LEIEQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDtfiglepevthkkyfamldaisqvqavpapiveavtplffanna 162
Cdd:COG0596   86 LGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD-------------------------------------------- 121

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855 163 eqanpELVASFKQSLEALQGERAVEVARIGRMVfgRRDVIEDAEMFALPTLIAVGREDKPRPVFESYLMNDCITGSELVE 242
Cdd:COG0596  122 -----EVLAALAEPLRRPGLAPEALAALLRALA--RTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVV 194

                        250       260
                 ....*....|....*....|....*..
gi 491592855 243 IPEAGHISSLEQPEIVNQMLLDFLNKV 269
Cdd:COG0596  195 LPGAGHFPPLEQPEAFAAALRDFLARL 221
protocat_pcaD TIGR02427
3-oxoadipate enol-lactonase; Members of this family are 3-oxoadipate enol-lactonase. Note that ...
 20-266 1.36e-37

3-oxoadipate enol-lactonase; Members of this family are 3-oxoadipate enol-lactonase. Note that the substrate is known as 3-oxoadipate enol-lactone, 2-oxo-2,3-dihydrofuran-5-acetate, 4,5-Dihydro-5-oxofuran-2-acetate, and 5-oxo-4,5-dihydrofuran-2-acetate. The enzyme the catalyzes the fourth step in the protocatechuate degradation to beta-ketoadipate and then to succinyl-CoA and acetyl-CoA. 4-hydroxybenzoate, 3-hydroxybenzoate, and vanillate all can be converted in one step to protocatechuate. This enzyme also acts in catechol degradation. In genomes that catabolize both catechol and protocatechuate, two forms of this enzyme may be found. All members of the seed alignment for this model were chosen from within protocatechuate degradation operons of at least three genes of the pathway, from genomes with the complete pathway through beta-ketoadipate. [Energy metabolism, Other]


Pssm-ID: 131480 [Multi-domain]  Cd Length: 251  Bit Score: 132.87  E-value: 1.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   20 PVLLFGHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGESDAaPASTRSLVDYAQHMLALMDHLEIEQFSIVGLSVGGMW 99
Cdd:TIGR02427  14 PVLVFINSLGTDLRMWDPVLPALTPDFRVLRYDKRGHGLSDA-PEGPYSIEDLADDVLALLDHLGIERAVFCGLSLGGLI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  100 GAELTSQAPQRVKSLVLMDTF--IGlepevTHKKYFAMLDAISQvQAVPApIVEAVTPLFFANNAEQANPELVASFKQSL 177
Cdd:TIGR02427  93 AQGLAARRPDRVRALVLSNTAakIG-----TPESWNARIAAVRA-EGLAA-LADAVLERWFTPGFREAHPARLDLYRNML 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  178 EA--LQGeRAVEVARIGRMvfgrrDVIEDAEMFALPTLIAVGREDKPRPVFESYLMNDCITGSELVEIPEAGHISSLEQP 255
Cdd:TIGR02427 166 VRqpPDG-YAGCCAAIRDA-----DFRDRLGAIAVPTLCIAGDQDGSTPPELVREIADLVPGARFAEIRGAGHIPCVEQP 239

                         250
                  ....*....|.
gi 491592855  256 EIVNQMLLDFL 266
Cdd:TIGR02427 240 EAFNAALRDFL 250
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 5-269 4.07e-22

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 94.24  E-value: 4.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   5 EIEGQQLAYLDKGEG---PVLLFgHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGESDAAPASTrSLVDYAQHMLALMD 81
Cdd:PRK14875 115 RIGGRTVRYLRLGEGdgtPVVLI-HGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASSKAVGAG-SLDELAAAVLAFLD 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  82 HLEIEQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDTfIGLEPEVTHKKYFAMLDAISQVQAVPapiveAVTPLFfann 161
Cdd:PRK14875 193 ALGIERAHLVGHSMGGAVALRLAARAPQRVASLTLIAP-AGLGPEINGDYIDGFVAAESRRELKP-----VLELLF---- 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855 162 aeqANPELVAsfKQSLEALQGERAVEVAR-----IGRMVFG----RRDVIEDAEMFALPTLIAVGREDKPRPVFESYLMN 232
Cdd:PRK14875 263 ---ADPALVT--RQMVEDLLKYKRLDGVDdalraLADALFAggrqRVDLRDRLASLAIPVLVIWGEQDRIIPAAHAQGLP 337

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 491592855 233 DcitGSELVEIPEAGHISSLEQPEIVNQMLLDFLNKV 269
Cdd:PRK14875 338 D---GVAVHVLPGAGHMPQMEAAADVNRLLAEFLGKA 371
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 20-255 8.15e-21

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 88.33  E-value: 8.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   20 PVLLFGHSYLWDNQMWAPQIEVLSQS-YRCIVPDLWAHGESDAAPASTR-SLVDYAQHMLALMDHLEIEQFSIVGLSVGG 97
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDgFRVIALDLRGFGKSSRPKAQDDyRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   98 MWGAELTSQAPQRVKSLVLMDT-----FIGLEPEVTHKKYFAMLDAISQVQAVP--APIVEA-VTPLFFANNAEQANPEL 169
Cdd:pfam00561  81 LIALAYAAKYPDRVKALVLLGAldpphELDEADRFILALFPGFFDGFVADFAPNplGRLVAKlLALLLLRLRLLKALPLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  170 VASFKqslealQGERAVEVARIGRMVFGRRDVIEDAEMFAL-----PTLIAVGREDKPRPVFESYLMNDCITGSELVEIP 244
Cdd:pfam00561 161 NKRFP------SGDYALAKSLVTGALLFIETWSTELRAKFLgrldePTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIP 234

                         250
                  ....*....|.
gi 491592855  245 EAGHISSLEQP 255
Cdd:pfam00561 235 DAGHFAFLEGP 245
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 18-267 2.24e-16

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 76.49  E-value: 2.24e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   18 EGPVLLFGHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGESDAAPASTR-SLVDYAQHMLA-LMDHLEIEQFSIVGLSV 95
Cdd:TIGR03695   1 AKPVLVFLHGFLGSGADWQALIEALGPHFRCLAIDLPGHGSSQSPSDIERyDFEEAAQLLLAtLLDQLGIEPFFLVGYSM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   96 GGMWGAELTSQAPQRVKSLVLMDTFIGLEPEVTHKKYFAMLDAISQV--QAvpaPIVEAVT-----PLF---FANNAEQA 165
Cdd:TIGR03695  81 GGRIALYYALQYPERVQGLILESGSPGLQTEEERAARRQNDEQLAQRfeQE---GLEAFLDdwyqqPLFasqKNLPPEQR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  166 ----------NPELVAsfkQSLEALQgeravevarIGRMvfgrRDVIEDAEMFALPTLIAVGREDkprpvfESYL----- 230
Cdd:TIGR03695 158 qalraerlanNPEGLA---KMLRATG---------LGKQ----PSLWPKLQALKIPVLYLCGERD------EKFVqiake 215

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 491592855  231 MNDCITGSELVEIPEAGHISSLEQPEIVNQMLLDFLN 267
Cdd:TIGR03695 216 MQKLIPNLTLHIIPNAGHNIHLENPEAFAKILLAFLE 252
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 5-121 6.23e-15

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 73.10  E-value: 6.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   5 EIEGQQLAYLDKGEGPVLLFGH-----SYLWDNQMwaPQievLSQSYRCIVPDLWAHGESDAAPASTRsLVDYAQHMLAL 79
Cdd:PRK03592  13 EVLGSRMAYIETGEGDPIVFLHgnptsSYLWRNII--PH---LAGLGRCLAPDLIGMGASDKPDIDYT-FADHARYLDAW 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491592855  80 MDHLEIEQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDTFI 121
Cdd:PRK03592  87 FDALGLDDVVLVGHDWGSALGFDWAARHPDRVRGIAFMEAIV 128
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 15-272 3.96e-12

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 66.03  E-value: 3.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   15 DKGEGPVLLFGHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGES---------DAAPASTRSLVdyAQHMLALMDHLEI 85
Cdd:PLN02980 1367 QNAEGSVVLFLHGFLGTGEDWIPIMKAISGSARCISIDLPGHGGSkiqnhaketQTEPTLSVELV--ADLLYKLIEHITP 1444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   86 EQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDTFIGLEPEVTHKKYFAMLDAISQVqavpapIVEAVTPLFFAN----- 160
Cdd:PLN02980 1445 GKVTLVGYSMGARIALYMALRFSDKIEGAVIISGSPGLKDEVARKIRSAKDDSRARM------LIDHGLEIFLENwysge 1518

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  161 --NAEQANPE---LVASFKQSLEALQGERAVEVARIGRmvfgRRDVIEDAEMFALPTLIAVGREDKP------RPVFESY 229
Cdd:PLN02980 1519 lwKSLRNHPHfnkIVASRLLHKDVPSLAKLLSDLSIGR----QPSLWEDLKQCDTPLLLVVGEKDVKfkqiaqKMYREIG 1594

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 491592855  230 LMNDCITGS-----ELVEIPEAGHISSLEQPEIVNQMLLDFLNKVHAS 272
Cdd:PLN02980 1595 KSKESGNDKgkeiiEIVEIPNCGHAVHLENPLPVIRALRKFLTRLHNS 1642
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
7-149 4.32e-11

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 61.17  E-value: 4.32e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   7 EGQQLAYL----DKGEGPVLLFGHSYLWDNQMWAPQIEVLSQS-YRCIVPDLWAHGESDAAPASTRSLVDYAQHMLALMD 81
Cdd:COG2267   12 DGLRLRGRrwrpAGSPRGTVVLVHGLGEHSGRYAELAEALAAAgYAVLAFDLRGHGRSDGPRGHVDSFDDYVDDLRAALD 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491592855  82 HLEIEQFS---IVGLSVGGMWGAELTSQAPQRVKSLVLMDTFIGLEPEVTHK-KYFAMLDAISQVQAVPAPI 149
Cdd:COG2267   92 ALRARPGLpvvLLGHSMGGLIALLYAARYPDRVAGLVLLAPAYRADPLLGPSaRWLRALRLAEALARIDVPV 163
PRK10673 PRK10673
esterase;
42-140 1.08e-08

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 54.74  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  42 LSQSYRCIVPDLWAHGESDAAPASTRSlvDYAQHMLALMDHLEIEQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDTFI 121
Cdd:PRK10673  39 LVNDHDIIQVDMRNHGLSPRDPVMNYP--AMAQDLLDTLDALQIEKATFIGHSMGGKAVMALTALAPDRIDKLVAIDIAP 116

                         90
                 ....*....|....*....
gi 491592855 122 GLEPEVTHKKYFAMLDAIS 140
Cdd:PRK10673 117 VDYHVRRHDEIFAAINAVS 135
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 10-256 1.83e-08

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 54.09  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  10 QLAYLDKGEGPVLLFGHSylwdNQMWA----PQIEVLSQSYRCIVPDLWAHGESDAAPASTRSLVDYAQHMLALMDHLEI 85
Cdd:PRK03204  25 RIHYIDEGTGPPILLCHG----NPTWSflyrDIIVALRDRFRCVAPDYLGFGLSERPSGFGYQIDEHARVIGEFVDHLGL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  86 EQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDTFIGLEPEVTHKKYFAMLDAISQVQAV-----------PAPIVEAVT 154
Cdd:PRK03204 101 DRYLSMGQDWGGPISMAVAVERADRVRGVVLGNTWFWPADTLAMKAFSRVMSSPPVQYAIlrrnffverliPAGTEHRPS 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855 155 PLFFAN-NAEQANPELVASFKQSLEALQGERAVeVARIGRMVfgrrdvieDAEMFALPTLIAVGREDK---PRPVFESyl 230
Cdd:PRK03204 181 SAVMAHyRAVQPNAAARRGVAEMPKQILAARPL-LARLAREV--------PATLGTKPTLLVWGMKDVafrPKTILPR-- 249

                        250       260
                 ....*....|....*....|....*.
gi 491592855 231 MNDCITGSELVEIPEAGHISSLEQPE 256
Cdd:PRK03204 250 LRATFPDHVLVELPNAKHFIQEDAPD 275
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
13-271 5.18e-08

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 52.64  E-value: 5.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  13 YLDKGEGPVLLFgHSYL---WDNQMWAPQIEvlSQSYRCIVPDLWAHGESDAAPAST------RSLVDYAQHMLALMDHL 83
Cdd:COG1647   10 FLEGGRKGVLLL-HGFTgspAEMRPLAEALA--KAGYTVYAPRLPGHGTSPEDLLKTtwedwlEDVEEAYEILKAGYDKV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  84 eieqfSIVGLSVGGMWGAELTSQAPQrVKSLVLMDTFIglepevthkkyfamldAISQVQAVPAPIVEAVTPLFFANNAE 163
Cdd:COG1647   87 -----IVIGLSMGGLLALLLAARYPD-VAGLVLLSPAL----------------KIDDPSAPLLPLLKYLARSLRGIGSD 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855 164 QANPElvasfkQSLEALQGERAVEVARIGRMVfgrRDVIEDAEMFALPTLIAVGREDKPRPVFESYLMNDCITGS--ELV 241
Cdd:COG1647  145 IEDPE------VAEYAYDRTPLRALAELQRLI---REVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPdkELV 215

                        250       260       270
                 ....*....|....*....|....*....|.
gi 491592855 242 EIPEAGH-ISSLEQPEIVNQMLLDFLNKVHA 271
Cdd:COG1647  216 WLEDSGHvITLDKDREEVAEEILDFLERLAA 246
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 17-265 7.58e-07

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 49.35  E-value: 7.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  17 GEGPVLLFGHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGESD------AAPASTRSLVDYAQHMLALMDHLEIEQFSI 90
Cdd:PLN02824  27 TSGPALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSDkpnprsAPPNSFYTFETWGEQLNDFCSDVVGDPAFV 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  91 VGLSVGGMWGAELTSQAPQRVKSLVLMDtfIGLEpevthkkyfaMLDaISQVQAVPAPIVEAV------TPL---FFANn 161
Cdd:PLN02824 107 ICNSVGGVVGLQAAVDAPELVRGVMLIN--ISLR----------GLH-IKKQPWLGRPFIKAFqnllreTAVgkaFFKS- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855 162 aeQANPELVAS-FKQSL---EALQGERAVEVARIGrMVFGRRDVIED----------AEMFAL---PTLIAVGREDKPRP 224
Cdd:PLN02824 173 --VATPETVKNiLCQCYhddSAVTDELVEAILRPG-LEPGAVDVFLDfisysggplpEELLPAvkcPVLIAWGEKDPWEP 249

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 491592855 225 VFESYLMNDCITGSELVEIPEAGHISSLEQPEIVNQMLLDF 265
Cdd:PLN02824 250 VELGRAYANFDAVEDFIVLPGVGHCPQDEAPELVNPLIESF 290
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 11-121 8.16e-07

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 49.20  E-value: 8.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  11 LAYLDKG--EGPVLLFGH-----SYLWdNQMwapqIEVLSQS-YRCIVPDLWAHGESDAaPAStRSLVDYAQH---MLAL 79
Cdd:PRK00870  36 MHYVDEGpaDGPPVLLLHgepswSYLY-RKM----IPILAAAgHRVIAPDLIGFGRSDK-PTR-REDYTYARHvewMRSW 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 491592855  80 MDHLEIEQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDTFI 121
Cdd:PRK00870 109 FEQLDLTDVTLVCQDWGGLIGLRLAAEHPDRFARLVVANTGL 150
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 42-260 4.84e-06

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 46.31  E-value: 4.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   42 LSQSYRCIVPDLWAHGESDAAPASTRSLVDYAQHMLALmdhLEIEQFSIVGLSVGGMWGAELTSQAPQRVkslVLMDTFi 121
Cdd:pfam12697  18 LAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDEL---GAARPVVLVGHSLGGAVALAAAAAALVVG---VLVAPL- 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  122 glepevthkkyFAMLDAISQVQAVPAPIVEAVTPLFFAnnaeqANPELVASFKQSLEALQGERAVEVARIGRMVFGRRDV 201
Cdd:pfam12697  91 -----------AAPPGLLAALLALLARLGAALAAPAWL-----AAESLARGFLDDLPADAEWAAALARLAALLAALALLP 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 491592855  202 IEDAEMFALPTLIAVGREDKPRPVFESYLMNdcITGSELVEIPEAGHiSSLEQPEIVNQ 260
Cdd:pfam12697 155 LAAWRDLPVPVLVLAEEDRLVPELAQRLLAA--LAGARLVVLPGAGH-LPLDDPEEVAE 210
metX PRK00175
homoserine O-acetyltransferase; Provisional
 73-115 5.08e-04

homoserine O-acetyltransferase; Provisional


Pssm-ID: 234678 [Multi-domain]  Cd Length: 379  Bit Score: 40.94  E-value: 5.08e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 491592855  73 AQHMLAlmDHLEIEQ-FSIVGLSVGGMWGAELTSQAPQRVKSLV 115
Cdd:PRK00175 135 AQARLL--DALGITRlAAVVGGSMGGMQALEWAIDYPDRVRSAL 176
PRK08775 PRK08775
homoserine O-succinyltransferase;
71-116 9.32e-04

homoserine O-succinyltransferase;


Pssm-ID: 181553 [Multi-domain]  Cd Length: 343  Bit Score: 40.16  E-value: 9.32e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 491592855  71 DYAQHMLALMDHLEIEQ-FSIVGLSVGGMWGAELTSQAPQRVKSLVL 116
Cdd:PRK08775 122 DQADAIALLLDALGIARlHAFVGYSYGALVGLQFASRHPARVRTLVV 168
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 1-118 1.00e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 40.21  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   1 MNKFEIEGQ-QLAYLDKGEG-------PVLL---FGHSYlwdnQMWAPQIEVLSQSYRCIVPDLWAHGESDAAPASTRSL 69
Cdd:PLN02679  63 CKKWKWKGEySINYLVKGSPevtssgpPVLLvhgFGASI----PHWRRNIGVLAKNYTVYAIDLLGFGASDKPPGFSYTM 138

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 491592855  70 VDYAQHMLALMDHLEIEQFSIVGLSVGGMWGAELTSQAPQR-VKSLVLMD 118
Cdd:PLN02679 139 ETWAELILDFLEEVVQKPTVLIGNSVGSLACVIAASESTRDlVRGLVLLN 188
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 19-109 1.36e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 39.05  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855  19 GPVLLFGHSYLWDNQMWAPQIEVLSQsYRCIVPDLWAHGESDAAPAStrSLVDYAQHMLALMDHLEIEQFSIVGLSVGG- 97
Cdd:PRK11126   2 LPWLVFLHGLLGSGQDWQPVGEALPD-YPRLYIDLPGHGGSAAISVD--GFADVSRLLSQTLQSYNILPYWLVGYSLGGr 78

                         90
                 ....*....|....
gi 491592855  98 --MWGAeLTSQAPQ 109
Cdd:PRK11126  79 iaMYYA-CQGLAGG 91
PLN02578 PLN02578
hydrolase
 2-119 7.88e-03

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 37.13  E-value: 7.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491592855   2 NKFEIEGQQLAYLDKGEGPVLLFGHSYLWDNQMWAPQIEVLSQSYRCIVPDLWAHGESDAApastrsLVDY-----AQHM 76
Cdd:PLN02578  69 NFWTWRGHKIHYVVQGEGLPIVLIHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSDKA------LIEYdamvwRDQV 142

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 491592855  77 LALMDHLEIEQFSIVGLSVGGMWGAELTSQAPQRVKSLVLMDT 119
Cdd:PLN02578 143 ADFVKEVVKEPAVLVGNSLGGFTALSTAVGYPELVAGVALLNS 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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