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Conserved domains on  [gi|491602989|ref|WP_005460549|]
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class I SAM-dependent methyltransferase [Vibrio parahaemolyticus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 12152148)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 29-141 3.03e-20

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


:

Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 86.61  E-value: 3.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  29 ASWRAFWPQARDRVLDVGAGSGRDAKWMAEHGCEVIAIEPAQALLRFGKSYCGD-SVTWLEDGLPKLEKTINlgfRFDLI 107
Cdd:COG2227   15 AALLARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAElNVDFVQGDLEDLPLEDG---SFDLV 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491602989 108 LVSAVWMHLapTHRERAFRKLANLLAPNGRLVIS 141
Cdd:COG2227   92 ICSEVLEHL--PDPAALLRELARLLKPGGLLLLS 123
HNHc super family cl00083
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 455-492 1.47e-03

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


The actual alignment was detected with superfamily member pfam13395:

Pssm-ID: 469607 [Multi-domain]  Cd Length: 55  Bit Score: 36.84  E-value: 1.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 491602989  455 NEYHVDHCLPFAYWPNNDKWNLLPTSKAENLNKRDRIP 492
Cdd:pfam13395  17 KNYDIDHILPYSRSFDDSFSNKVLVLRSANQEKGNRTP 54
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 29-141 3.03e-20

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 86.61  E-value: 3.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  29 ASWRAFWPQARDRVLDVGAGSGRDAKWMAEHGCEVIAIEPAQALLRFGKSYCGD-SVTWLEDGLPKLEKTINlgfRFDLI 107
Cdd:COG2227   15 AALLARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAElNVDFVQGDLEDLPLEDG---SFDLV 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491602989 108 LVSAVWMHLapTHRERAFRKLANLLAPNGRLVIS 141
Cdd:COG2227   92 ICSEVLEHL--PDPAALLRELARLLKPGGLLLLS 123
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 42-136 1.99e-16

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 74.52  E-value: 1.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989   42 VLDVGAGSGRDAKWMAEH-GCEVIAIEPAQALLRFGKSYCGDS---VTWLE---DGLPKLEKTinlgfrFDLILVSAVWM 114
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAglnVEFVQgdaEDLPFPDGS------FDLVVSSGVLH 74

                          90       100
                  ....*....|....*....|..
gi 491602989  115 HLAPTHRERAFRKLANLLAPNG 136
Cdd:pfam13649  75 HLPDPDLEAALREIARVLKPGG 96
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 41-145 1.12e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 61.68  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  41 RVLDVGAGSGRDAKWMAEH-GCEVIAIEPAQALLRFGKSYC----GDSVTWLEDGLPKLEKTINLgfRFDLILVSAVWMH 115
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAaallADNVEVLKGDAEELPPEADE--SFDVIISDPPLHH 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 491602989 116 LaPTHRERAFRKLANLLAPNGRLVISLRHG 145
Cdd:cd02440   79 L-VEDLARFLEEARRLLKPGGVLVLTLVLA 107
PRK08317 PRK08317
hypothetical protein; Provisional
 28-141 6.56e-08

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 53.79  E-value: 6.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  28 HASWRAFWPQARDRVLDVGAGSGRDAKWMAEHGC---EVIAIEPAQALLRFGKSYCGDSVTWLE------DGLPklekti 98
Cdd:PRK08317   9 ARTFELLAVQPGDRVLDVGCGPGNDARELARRVGpegRVVGIDRSEAMLALAKERAAGLGPNVEfvrgdaDGLP------ 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 491602989  99 nlgF---RFDLILVSAVWMHLAptHRERAFRKLANLLAPNGRLVIS 141
Cdd:PRK08317  83 ---FpdgSFDAVRSDRVLQHLE--DPARALAEIARVLRPGGRVVVL 123
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 42-69 1.38e-03

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 39.22  E-value: 1.38e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 491602989   42 VLDVGAGSGRDAKWMAEHG--CEVIAIEPA 69
Cdd:TIGR01444   2 VIDVGANIGDTSLYFARKGaeGRVIAFEPL 31
HNH_4 pfam13395
HNH endonuclease; This HNH nuclease domain is found in CRISPR-related proteins.
 455-492 1.47e-03

HNH endonuclease; This HNH nuclease domain is found in CRISPR-related proteins.


Pssm-ID: 433172 [Multi-domain]  Cd Length: 55  Bit Score: 36.84  E-value: 1.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 491602989  455 NEYHVDHCLPFAYWPNNDKWNLLPTSKAENLNKRDRIP 492
Cdd:pfam13395  17 KNYDIDHILPYSRSFDDSFSNKVLVLRSANQEKGNRTP 54
 
Name Accession Description Interval E-value
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 29-141 3.03e-20

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 86.61  E-value: 3.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  29 ASWRAFWPQARDRVLDVGAGSGRDAKWMAEHGCEVIAIEPAQALLRFGKSYCGD-SVTWLEDGLPKLEKTINlgfRFDLI 107
Cdd:COG2227   15 AALLARLLPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAAElNVDFVQGDLEDLPLEDG---SFDLV 91

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491602989 108 LVSAVWMHLapTHRERAFRKLANLLAPNGRLVIS 141
Cdd:COG2227   92 ICSEVLEHL--PDPAALLRELARLLKPGGLLLLS 123
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 36-141 4.79e-17

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 78.11  E-value: 4.79e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  36 PQARDRVLDVGAGSGRDAKWMAEHGCEVIAIEPAQALLRFGK---SYCGDSVTWLE-DGLpklektiNLGFR---FDLIL 108
Cdd:COG2226   20 LRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELAReraAEAGLNVEFVVgDAE-------DLPFPdgsFDLVI 92

                         90       100       110
                 ....*....|....*....|....*....|...
gi 491602989 109 VSAVWMHLAptHRERAFRKLANLLAPNGRLVIS 141
Cdd:COG2226   93 SSFVLHHLP--DPERALAEIARVLKPGGRLVVV 123
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 42-136 1.99e-16

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 74.52  E-value: 1.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989   42 VLDVGAGSGRDAKWMAEH-GCEVIAIEPAQALLRFGKSYCGDS---VTWLE---DGLPKLEKTinlgfrFDLILVSAVWM 114
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRgGARVTGVDLSPEMLERARERAAEAglnVEFVQgdaEDLPFPDGS------FDLVVSSGVLH 74

                          90       100
                  ....*....|....*....|..
gi 491602989  115 HLAPTHRERAFRKLANLLAPNG 136
Cdd:pfam13649  75 HLPDPDLEAALREIARVLKPGG 96
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
41-141 2.74e-16

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 74.47  E-value: 2.74e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  41 RVLDVGAGSGRDAKWMAEH--GCEVIAIEPAQALLRFGKSYCGDsVTWLEDGLPklekTINLGFRFDLILVSAVWMHLAp 118
Cdd:COG4106    4 RVLDLGCGTGRLTALLAERfpGARVTGVDLSPEMLARARARLPN-VRFVVADLR----DLDPPEPFDLVVSNAALHWLP- 77

                         90       100
                 ....*....|....*....|...
gi 491602989 119 tHRERAFRKLANLLAPNGRLVIS 141
Cdd:COG4106   78 -DHAALLARLAAALAPGGVLAVQ 99
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 40-140 1.01e-13

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 68.80  E-value: 1.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  40 DRVLDVGAGSGRDAKWMAEH-GCEVIAIEPAQALLRFGKSYC-----GDSVTWLEDGLPKLEKTinlGfRFDLILVSAVW 113
Cdd:COG2230   53 MRVLDIGCGWGGLALYLARRyGVRVTGVTLSPEQLEYARERAaeaglADRVEVRLADYRDLPAD---G-QFDAIVSIGMF 128

                         90       100
                 ....*....|....*....|....*..
gi 491602989 114 MHLAPTHRERAFRKLANLLAPNGRLVI 140
Cdd:COG2230  129 EHVGPENYPAYFAKVARLLKPGGRLLL 155
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 43-140 1.55e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 66.53  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989   43 LDVGAGSGRDAKWMAEHGCEVIAIEPAQALLRFGKS-YCGDSVTWLE-DGLpklektiNLGFR---FDLILVSAVWMHLA 117
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREkAPREGLTFVVgDAE-------DLPFPdnsFDLVLSSEVLHHVE 73

                          90       100
                  ....*....|....*....|...
gi 491602989  118 PthRERAFRKLANLLAPNGRLVI 140
Cdd:pfam08241  74 D--PERALREIARVLKPGGILII 94
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
32-155 2.52e-12

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 65.40  E-value: 2.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  32 RAFWPQARDRVLDVGAGSGRDAKWMAEHGCEVIAIEPAQALLRFGKSYcGDSVTWLEDGLPKLEktiNLGFRFDLILVSA 111
Cdd:COG4976   40 ARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREK-GVYDRLLVADLADLA---EPDGRFDLIVAAD 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 491602989 112 VWMHLAPThrERAFRKLANLLAPNGRLVISLRHGDfSDGRKAYP 155
Cdd:COG4976  116 VLTYLGDL--AAVFAGVARALKPGGLFIFSVEDAD-GSGRYAHS 156
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 41-142 4.42e-12

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 65.32  E-value: 4.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  41 RVLDVGAGSGRDAKWMAEHGCE-VIAIEPAQALLRFGKSYCG----DSVTWLEDGLPKLEKtINLGfRFDLILVSAVWMH 115
Cdd:COG0500   29 RVLDLGCGTGRNLLALAARFGGrVIGIDLSPEAIALARARAAkaglGNVEFLVADLAELDP-LPAE-SFDLVVAFGVLHH 106

                         90       100
                 ....*....|....*....|....*..
gi 491602989 116 LAPTHRERAFRKLANLLAPNGRLVISL 142
Cdd:COG0500  107 LPPEEREALLRELARALKPGGVLLLSA 133
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 43-138 7.21e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 62.00  E-value: 7.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989   43 LDVGAGSGRDAKWMAEH--GCEVIAIEPAQALLRFGK----SYCGDSVTWLEdgLPKLEKTINLGFRFDLILVSAVWMHL 116
Cdd:pfam08242   1 LEIGCGTGTLLRALLEAlpGLEYTGLDISPAALEAARerlaALGLLNAVRVE--LFQLDLGELDPGSFDVVVASNVLHHL 78

                          90       100
                  ....*....|....*....|..
gi 491602989  117 AptHRERAFRKLANLLAPNGRL 138
Cdd:pfam08242  79 A--DPRAVLRNIRRLLKPGGVL 98
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 41-145 1.12e-11

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 61.68  E-value: 1.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  41 RVLDVGAGSGRDAKWMAEH-GCEVIAIEPAQALLRFGKSYC----GDSVTWLEDGLPKLEKTINLgfRFDLILVSAVWMH 115
Cdd:cd02440    1 RVLDLGCGTGALALALASGpGARVTGVDISPVALELARKAAaallADNVEVLKGDAEELPPEADE--SFDVIISDPPLHH 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 491602989 116 LaPTHRERAFRKLANLLAPNGRLVISLRHG 145
Cdd:cd02440   79 L-VEDLARFLEEARRLLKPGGVLVLTLVLA 107
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 33-174 1.20e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 57.44  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989   33 AFWPQARDRVLDVGAGSGRDAKWMAEHGCEVIAIEPAQALLRFGKSYCGDSVTWLEDGLPKLEKtinlgfrFDLILVSAV 112
Cdd:pfam13489  17 LPKLPSPGRVLDFGCGTGIFLRLLRAQGFSVTGVDPSPIAIERALLNVRFDQFDEQEAAVPAGK-------FDVIVAREV 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491602989  113 WMHLAPTHreRAFRKLANLLAPNGRLVISLrhgdfsdgrkaYPVSVEELEKFAKNRALMVRN 174
Cdd:pfam13489  90 LEHVPDPP--ALLRQIAALLKPGGLLLLST-----------PLASDEADRLLLEWPYLRPRN 138
PRK08317 PRK08317
hypothetical protein; Provisional
 28-141 6.56e-08

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 53.79  E-value: 6.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  28 HASWRAFWPQARDRVLDVGAGSGRDAKWMAEHGC---EVIAIEPAQALLRFGKSYCGDSVTWLE------DGLPklekti 98
Cdd:PRK08317   9 ARTFELLAVQPGDRVLDVGCGPGNDARELARRVGpegRVVGIDRSEAMLALAKERAAGLGPNVEfvrgdaDGLP------ 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 491602989  99 nlgF---RFDLILVSAVWMHLAptHRERAFRKLANLLAPNGRLVIS 141
Cdd:PRK08317  83 ---FpdgSFDAVRSDRVLQHLE--DPARALAEIARVLRPGGRVVVL 123
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 38-140 1.84e-07

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 53.04  E-value: 1.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  38 ARDRVLDVGAGSGrDAKWMA----EHGCEVIAIEPAQALLRFGK----SYCGDSVTWLEDGLPKLEKTINLGfRFDLILV 109
Cdd:COG5459   80 APLTVLDVGAGPG-TAAWAAadawPSLLDATLLERSAAALALGRrlarAAANPALETAEWRLADLAAALPAP-PADLVVA 157

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491602989 110 SAVWMHLAPTHRERAFRKLanLLAPNGRLVI 140
Cdd:COG5459  158 SYVLNELADAARAALVDRL--WLAPDGALLI 186
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 36-145 1.19e-06

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 49.32  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  36 PQARDRVLDVGAGSGrdakW----MAEHGCEVIAIEPAQALLRFGKSY------------CGDsvtwLEDGLPKlektin 99
Cdd:COG2518   64 LKPGDRVLEIGTGSG----YqaavLARLAGRVYSVERDPELAERARERlaalgydnvtvrVGD----GALGWPE------ 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 491602989 100 lGFRFDLILVSAvwmhlAPTHRERAfrkLANLLAPNGRLVISLRHG 145
Cdd:COG2518  130 -HAPFDRIIVTA-----AAPEVPEA---LLEQLAPGGRLVAPVGEG 166
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 41-141 1.15e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 42.40  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989   41 RVLDVGAGSGRDAKWMAE---HGCEVIAIEPAQALLRFGKSYCGDS----VTWLEDGLPKLEKTINLGfRFDLILVSAVW 113
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEelgPNAEVVGIDISEEAIEKARENAQKLgfdnVEFEQGDIEELPELLEDD-KFDVVISNCVL 84

                          90       100
                  ....*....|....*....|....*...
gi 491602989  114 MHLAptHRERAFRKLANLLAPNGRLVIS 141
Cdd:pfam13847  85 NHIP--DPDKVLQEILRVLKPGGRLIIS 110
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 28-140 1.37e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 43.60  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  28 HASWRAF---W--PQARDRVLDVGAGSGRDAKWMAEHG---CEVIAIEPAQALL-----RFGKSYCGDSVTWLE-DGLpk 93
Cdd:PRK00216  36 HRVWRRKtikWlgVRPGDKVLDLACGTGDLAIALAKAVgktGEVVGLDFSEGMLavgreKLRDLGLSGNVEFVQgDAE-- 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 491602989  94 lektiNLGF---RFDLILVS----AVwmhlapTHRERAFRKLANLLAPNGRLVI 140
Cdd:PRK00216 114 -----ALPFpdnSFDAVTIAfglrNV------PDIDKALREMYRVLKPGGRLVI 156
TPMT pfam05724
Thiopurine S-methyltransferase (TPMT); This family consists of thiopurine S-methyltransferase ...
 13-142 1.74e-04

Thiopurine S-methyltransferase (TPMT); This family consists of thiopurine S-methyltransferase proteins from both eukaryotes and prokaryotes. Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes S-methylation of aromatic and heterocyclic sulfhydryl compounds, including anticancer and immunosuppressive thiopurines.


Pssm-ID: 399030  Cd Length: 218  Bit Score: 43.18  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989   13 DCLAEQYTSLKFEDVHASWRAFWP----QARDRVLDVGAGSGRDAKWMAEHGCEVIAIEPAQALLR-------------- 74
Cdd:pfam05724   8 KRWVEGQTPFHQEGVNPLLVRHWDalklPPGLRVLVPLCGKALDMVWLAEQGHFVVGVEISELAVEkffaeaglsppite 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491602989   75 --FGKSY--------CGDSVTWLEDGLPKlektinlgfrFDLILVSAVWMHLAPTHRERAFRKLANLLAPNGR-LVISL 142
Cdd:pfam05724  88 lsGFKEYssgnislyCGDFFTLPREELGK----------FDLIYDRAALCALPPEMRPRYAKQMYELLPPGGRgLLITL 156
SAM_MT pfam04445
Putative SAM-dependent methyltransferase; This is a family of putative SAM-dependent ...
 36-91 5.03e-04

Putative SAM-dependent methyltransferase; This is a family of putative SAM-dependent methyltransferases.


Pssm-ID: 427952  Cd Length: 230  Bit Score: 41.82  E-value: 5.03e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 491602989   36 PQARDRVLDVGAGSGRDAKWMAEHGCEVIAIE--PAQALLrfgksycgdsvtwLEDGL 91
Cdd:pfam04445  69 GGYLPTVLDATAGLGRDAFVLASLGCKVTLIErhPVVAAL-------------LEDGL 113
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 37-171 1.01e-03

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 40.17  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  37 QARdRVLDVGAGSGRDAKWMAE---HGCEVIAIEPAQALLRFGKSYC-----GDSVTWLE----DGLPKLEKTinlgfRF 104
Cdd:COG4122   16 GAK-RILEIGTGTGYSTLWLARalpDDGRLTTIEIDPERAAIARENFaraglADRIRLILgdalEVLPRLADG-----PF 89

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989 105 DLILVSAvwmhlAPTHRERAFRKLANLLAPNGrLVIS---LRHGDFSDGRKAYPvSVEELEKFakNRALM 171
Cdd:COG4122   90 DLVFIDA-----DKSNYPDYLELALPLLRPGG-LIVAdnvLWHGRVADPARRDP-STRAIREF--NEYLR 150
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
36-140 1.01e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 40.57  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  36 PQARDRVLDVGAGSGRDAKWMAEHGCEVIAIE-----PAQALLRFGKSYCGDSVTWLEDGlpklektiNLGFR----FDL 106
Cdd:PRK00312  76 LKPGDRVLEIGTGSGYQAAVLAHLVRRVFSVEriktlQWEAKRRLKQLGLHNVSVRHGDG--------WKGWPayapFDR 147

                         90       100       110
                 ....*....|....*....|....*....|....
gi 491602989 107 ILVSAvwmhlAPTHRERAfrkLANLLAPNGRLVI 140
Cdd:PRK00312 148 ILVTA-----AAPEIPRA---LLEQLKEGGILVA 173
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 42-69 1.38e-03

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 39.22  E-value: 1.38e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 491602989   42 VLDVGAGSGRDAKWMAEHG--CEVIAIEPA 69
Cdd:TIGR01444   2 VIDVGANIGDTSLYFARKGaeGRVIAFEPL 31
HNH_4 pfam13395
HNH endonuclease; This HNH nuclease domain is found in CRISPR-related proteins.
 455-492 1.47e-03

HNH endonuclease; This HNH nuclease domain is found in CRISPR-related proteins.


Pssm-ID: 433172 [Multi-domain]  Cd Length: 55  Bit Score: 36.84  E-value: 1.47e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 491602989  455 NEYHVDHCLPFAYWPNNDKWNLLPTSKAENLNKRDRIP 492
Cdd:pfam13395  17 KNYDIDHILPYSRSFDDSFSNKVLVLRSANQEKGNRTP 54
PRK14968 PRK14968
putative methyltransferase; Provisional
 40-67 3.05e-03

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 39.11  E-value: 3.05e-03
                         10        20
                 ....*....|....*....|....*...
gi 491602989  40 DRVLDVGAGSGRDAKWMAEHGCEVIAIE 67
Cdd:PRK14968  25 DRVLEVGTGSGIVAIVAAKNGKKVVGVD 52
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
41-138 5.71e-03

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 39.06  E-value: 5.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491602989  41 RVLDVGAGSGRDAKWMAEH-GCEVIAIEPAQALLRFGKSYCGdsvtwledGLP---KLEKTINLGFRFDLIlVSaVWM-- 114
Cdd:PRK11705 170 RVLDIGCGWGGLARYAAEHyGVSVVGVTISAEQQKLAQERCA--------GLPveiRLQDYRDLNGQFDRI-VS-VGMfe 239

                         90       100
                 ....*....|....*....|....
gi 491602989 115 HLAPTHRERAFRKLANLLAPNGRL 138
Cdd:PRK11705 240 HVGPKNYRTYFEVVRRCLKPDGLF 263
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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