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Conserved domains on  [gi|491603021|ref|WP_005460581|]
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MULTISPECIES: TrkA family potassium uptake protein [Vibrio]

Protein Classification

potassium channel family protein( domain architecture ID 11426271)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium translocate across cell membranes, similar to Trk system potassium uptake protein TrkA

CATH:  1.20.5.870|3.30.70.1450|3.40.50.720
Gene Ontology:  GO:0016020|GO:0022857|GO:0030001|GO:0034220
PubMed:  15816170|9525859|11836519|1772658|11178249
SCOP:  4000005|4000027
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 2-205 2.40e-52

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


:

Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 170.63  E-value: 2.40e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021   2 KTGDKQFAVIGLGRFGLAVCKELQDSGSQVLAVDINEDRVKEAAGFVSQAIVANCTHEETVAELKLDDYDMVMIAIGADv 81
Cdd:COG0569   92 KKLKMHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGDD- 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021  82 NASILATLIAKEAGVKSVWVKANDRFQARVLQKIGADHIIMPERDMGIRVARKMLDKRVLEFHPLGSG-LAMTEFVV--G 158
Cdd:COG0569  171 EANILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADGdAEIVEVTVpeG 250

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 491603021 159 SRLMGKTLSDLALCKVEGVQVLGFKRGPEIIkAPDMSTTLEIGDLII 205
Cdd:COG0569  251 SPLVGKTLKELDLRERYGVTVVAIKRGGEVI-IPSGDTVLEAGDELI 296
 
Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 2-205 2.40e-52

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 170.63  E-value: 2.40e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021   2 KTGDKQFAVIGLGRFGLAVCKELQDSGSQVLAVDINEDRVKEAAGFVSQAIVANCTHEETVAELKLDDYDMVMIAIGADv 81
Cdd:COG0569   92 KKLKMHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGDD- 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021  82 NASILATLIAKEAGVKSVWVKANDRFQARVLQKIGADHIIMPERDMGIRVARKMLDKRVLEFHPLGSG-LAMTEFVV--G 158
Cdd:COG0569  171 EANILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADGdAEIVEVTVpeG 250

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 491603021 159 SRLMGKTLSDLALCKVEGVQVLGFKRGPEIIkAPDMSTTLEIGDLII 205
Cdd:COG0569  251 SPLVGKTLKELDLRERYGVTVVAIKRGGEVI-IPSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 8-123 1.14e-28

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 104.14  E-value: 1.14e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021    8 FAVIGLGRFGLAVCKELQDSGsQVLAVDINEDRVKEAAGFVSQAIVANCTHEETVAELKLDDYDMVMIAIGADvNASILA 87
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSEGG-DVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGDD-EANILI 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 491603021   88 TLIAKE-AGVKSVWVKANDRFQARVLQKIGADHIIMP 123
Cdd:pfam02254  79 VLLARElNPDKKIIARANDPEHAELLRRLGADHVISP 115
trkA PRK09496
Trk system potassium transporter TrkA;
10-220 1.31e-15

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 74.77  E-value: 1.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021  10 VIGLGRFGLAVCKELQDSGSQVLAVDINEDRVKEAAGFVSQAIV--ANCTHEETVAELKLDDYDmVMIAIGADVNASILA 87
Cdd:PRK09496 236 IVGGGNIGYYLAKLLEKEGYSVKLIERDPERAEELAEELPNTLVlhGDGTDQELLEEEGIDEAD-AFIALTNDDEANILS 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021  88 TLIAKEAGVKSVWVKANDRFQARVLQKIGADHIIMPeRDMGIR-VARKMLDKRVLEFHPLGSGLAMT-EFVV--GSRLMG 163
Cdd:PRK09496 315 SLLAKRLGAKKVIALVNRPAYVDLVEGLGIDIAISP-RQATASeILRHVRRGDIVAVHSLRRGAAEAiEAVAheTSKVVG 393

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491603021 164 KTLSDLALCKveGVQVLGFKRGPEIIKAPDmSTTLEIGDLIIVVGPQDKLANKLKSL 220
Cdd:PRK09496 394 KPLKDLKLPK--GVLIGAIVRGGEVIIPTG-DTVIEPGDHVIVFVLDKKFVPDVEKL 447
2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_ cd08255
2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; This subgroup ...
 4-91 5.53e-03

2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; This subgroup of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family has members identified as 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase and alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.


Pssm-ID: 176217 [Multi-domain]  Cd Length: 277  Bit Score: 36.86  E-value: 5.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021   4 GDKqFAVIGLGRFGLAVCKELQDSG-SQVLAVDINEDRVKEAAGFVSqaivANCTHEETVAELKLDDYDMVMIAIGadvN 82
Cdd:cd08255   98 GER-VAVVGLGLVGLLAAQLAKAAGaREVVGVDPDAARRELAEALGP----ADPVAADTADEIGGRGADVVIEASG---S 169


                 ....*....
gi 491603021  83 ASILATLIA 91
Cdd:cd08255  170 PSALETALR 178
 
Name Accession Description Interval E-value
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 2-205 2.40e-52

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 170.63  E-value: 2.40e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021   2 KTGDKQFAVIGLGRFGLAVCKELQDSGSQVLAVDINEDRVKEAAGFVSQAIVANCTHEETVAELKLDDYDMVMIAIGADv 81
Cdd:COG0569   92 KKLKMHVIIIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVIVGDATDEEVLEEAGIEDADAVIAATGDD- 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021  82 NASILATLIAKEAGVKSVWVKANDRFQARVLQKIGADHIIMPERDMGIRVARKMLDKRVLEFHPLGSG-LAMTEFVV--G 158
Cdd:COG0569  171 EANILACLLAKELGVPRIIARANDPEYADLLERLGADVVISPERLAARRIARLLLRPGVLDVLELADGdAEIVEVTVpeG 250

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 491603021 159 SRLMGKTLSDLALCKVEGVQVLGFKRGPEIIkAPDMSTTLEIGDLII 205
Cdd:COG0569  251 SPLVGKTLKELDLRERYGVTVVAIKRGGEVI-IPSGDTVLEAGDELI 296
TrkA_N pfam02254
TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include ...
 8-123 1.14e-28

TrkA-N domain; This domain is found in a wide variety of proteins. These proteins include potassium channels, phosphoesterases, and various other transporters. This domain binds to NAD.


Pssm-ID: 426679 [Multi-domain]  Cd Length: 115  Bit Score: 104.14  E-value: 1.14e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021    8 FAVIGLGRFGLAVCKELQDSGsQVLAVDINEDRVKEAAGFVSQAIVANCTHEETVAELKLDDYDMVMIAIGADvNASILA 87
Cdd:pfam02254   1 IIIIGYGRVGRSLAEELSEGG-DVVVIDKDEERVEELREEGVPVVVGDATDEEVLEEAGIEEADAVIAATGDD-EANILI 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 491603021   88 TLIAKE-AGVKSVWVKANDRFQARVLQKIGADHIIMP 123
Cdd:pfam02254  79 VLLARElNPDKKIIARANDPEHAELLRRLGADHVISP 115
trkA PRK09496
Trk system potassium transporter TrkA;
10-220 1.31e-15

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 74.77  E-value: 1.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021  10 VIGLGRFGLAVCKELQDSGSQVLAVDINEDRVKEAAGFVSQAIV--ANCTHEETVAELKLDDYDmVMIAIGADVNASILA 87
Cdd:PRK09496 236 IVGGGNIGYYLAKLLEKEGYSVKLIERDPERAEELAEELPNTLVlhGDGTDQELLEEEGIDEAD-AFIALTNDDEANILS 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021  88 TLIAKEAGVKSVWVKANDRFQARVLQKIGADHIIMPeRDMGIR-VARKMLDKRVLEFHPLGSGLAMT-EFVV--GSRLMG 163
Cdd:PRK09496 315 SLLAKRLGAKKVIALVNRPAYVDLVEGLGIDIAISP-RQATASeILRHVRRGDIVAVHSLRRGAAEAiEAVAheTSKVVG 393

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491603021 164 KTLSDLALCKveGVQVLGFKRGPEIIKAPDmSTTLEIGDLIIVVGPQDKLANKLKSL 220
Cdd:PRK09496 394 KPLKDLKLPK--GVLIGAIVRGGEVIIPTG-DTVIEPGDHVIVFVLDKKFVPDVEKL 447
Kch COG1226
Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];
10-136 6.50e-14

Voltage-gated potassium channel Kch [Inorganic ion transport and metabolism];


Pssm-ID: 440839 [Multi-domain]  Cd Length: 279  Bit Score: 68.99  E-value: 6.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021  10 VIGLGRFGLAVCKELQDSGSQVLAVDINEDRVKEAAGFVSQAIVANCTHEETVAELKLDDYDMVMIAIgADVNASILATL 89
Cdd:COG1226  129 IAGFGRVGQIVARLLRAEGIPFVVIDLDPERVEELRRFGIKVYYGDATRPDVLEAAGIERARALVVAI-DDPEAALRIVE 207

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 491603021  90 IAKEA--GVKsVWVKANDRFQARVLQKIGADHIIMPERDMGIRVARKML 136
Cdd:COG1226  208 LARELnpDLK-IIARARDREHAEELRQAGADEVVRETFESALQLARHAL 255
trkA PRK09496
Trk system potassium transporter TrkA;
10-208 3.25e-11

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 61.68  E-value: 3.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021  10 VIGLGRFGLAVCKELQDSGSQVLAVDINEDRVKEAAG-FVSQAIVANCTHEETVAELKLDDYDMvMIAI-GAD-VNasIL 86
Cdd:PRK09496   5 IVGAGQVGYTLAENLSGENNDVTVIDTDEERLRRLQDrLDVRTVVGNGSSPDVLREAGAEDADL-LIAVtDSDeTN--MV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021  87 ATLIAKE-AGVKS--VWVKANDRFQARVL---QKIGADHIIMPERDMGIRVARKM-----LDkrVLEFHplGSGLAMTEF 155
Cdd:PRK09496  82 ACQIAKSlFGAPTtiARVRNPEYAEYDKLfskEALGIDLLISPELLVAREIARLIeypgaLD--VEEFA--DGRVQLVEV 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491603021 156 VV--GSRLMGKTLSDLA-LCKVEGVQVLGFKRGPEIIkAPDMSTTLEIGDLIIVVG 208
Cdd:PRK09496 158 KVyeGSPLVGKPLSDLReHFPDIDVRVVAIFRGGRLI-IPRGDTVIEAGDEVYFIG 212
KhtT COG0490
K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) ...
 124-214 4.19e-09

K+/H+ antiporter KhtSTU, c-di-AMP-binding regulatory subunit KhtT, contains RCK_C (TrkA_C) domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440256 [Multi-domain]  Cd Length: 140  Bit Score: 53.39  E-value: 4.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021 124 ERDMGIRVARKMLDKRVLEFHPLGSGLAMTEFVV--GSRLMGKTLSDLALCKVEGVQVLGFKRGPEIIKAPDMSTTLEIG 201
Cdd:COG0490   42 ELALLLLLLGELLRLLTRLLIELVLLLAIEEVKVppGSPLVGKTLGELNLRQRTGVTVVAIRRGGEVILSPGPDTVLEAG 121

                         90
                 ....*....|...
gi 491603021 202 DLIIVVGPQDKLA 214
Cdd:COG0490  122 DTLVVVGTREQLE 134
COG3273 COG3273
Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];
148-214 2.37e-07

Uncharacterized protein, contains PhoU and TrkA_C domains [General function prediction only];


Pssm-ID: 442504 [Multi-domain]  Cd Length: 387  Bit Score: 50.44  E-value: 2.37e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491603021 148 SGLAMTEFVV--GSRLMGKTLSDLALCKVEGVQVLGFKRGPEIIKAPDMSTTLEIGDLIIVVGPQDKLA 214
Cdd:COG3273  311 SDERIVRVTVppGSPLVGKTLGELKLETETGVRVIAIRRGGGWIYDPDGDTRLRAGDVLIVKGTREGLE 379
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 152-214 8.20e-07

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 45.29  E-value: 8.20e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491603021  152 MTEFVV--GSRLMGKTLSDLALCKVEGVQVLGFKRGPEIIkAPDMSTTLEIGDLIIVVGPQDKLA 214
Cdd:pfam02080   1 LVEVTVpeNSPLVGKTLKELNLPERFGVRIVAIRRGGRLI-IPSGDTVLEAGDRLLVIGTPDDLA 64
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 132-215 4.44e-06

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 46.66  E-value: 4.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021 132 ARKMLDKRVLEFHPLGSGLAMTEFVVGSR-LMGKTLSDLALCKVEGVQVLGFKR-GPEIIKAPDmsTTLEIGDLIIVVGP 209
Cdd:COG2985  268 AEALLGEEVDDSELLDSDLDVRRIVVTNKeVAGKTLGELNLRNRFGVVITRVRRgGVELPATPD--TVLQLGDRLTVVGP 345


                 ....*.
gi 491603021 210 QDKLAN 215
Cdd:COG2985  346 KEDVER 351
PRK04148 PRK04148
hypothetical protein; Provisional
 2-44 5.48e-04

hypothetical protein; Provisional


Pssm-ID: 235226  Cd Length: 134  Bit Score: 38.84  E-value: 5.48e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 491603021   2 KTGDKQFAVIGLGrFGLAVCKELQDSGSQVLAVDINEDRVKEA 44
Cdd:PRK04148  14 KGKNKKIVELGIG-FYFKVAKKLKESGFDVIVIDINEKAVEKA 55
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 5-100 8.20e-04

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 39.68  E-value: 8.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021   5 DKQFAVIGLGRFGLAVCKELQDSGSQVLAVDINEDRVKEAAGFVSQAIVancTHEETVAELKLDDYDMVMIAIGADVNAS 84
Cdd:COG0771    4 GKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAAELEAPGVE---VVLGEHPEELLDGADLVVKSPGIPPDHP 80

                         90
                 ....*....|....*.
gi 491603021  85 ILATliAKEAGVKsVW 100
Cdd:COG0771   81 LLKA--ARAAGIP-VI 93
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 7-123 8.67e-04

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 38.60  E-value: 8.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021    7 QFAVIGLGRFGLAVCKELQDSGSQVLAVDINEDRVKEaagFVSQAIVANCTHEETVAELkldDYDMVMIAIGADVNASIL 86
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEE---LVAAGAIAAASPAEFVAGL---DVVITMVPAGAAVDAVIF 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 491603021   87 ATLIAKEAGVKSVWV-------KANDRFqARVLQKIGADHIIMP 123
Cdd:pfam03446  75 GEGLLPGLKPGDIIIdgstsspEDARRR-AKELKEKGLHFLDAP 117
WecC COG0677
UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];
9-43 2.02e-03

UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440441 [Multi-domain]  Cd Length: 413  Bit Score: 38.50  E-value: 2.02e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 491603021   9 AVIGLGRFGLAVCKELQDSGSQVLAVDINEDRVKE 43
Cdd:COG0677    3 AVIGLGYVGLPLAVAFAKAGFRVIGFDINPERVEE 37
CoA_binding_2 pfam13380
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 6-101 2.86e-03

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 433162 [Multi-domain]  Cd Length: 116  Bit Score: 36.36  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021    6 KQFAVIGL----GRFGLAVCKELQDSGSQVLAVdiNEdRVKEAAGfvsqaivancthEETVAELKLDDY--DMVMIAIGA 79
Cdd:pfam13380   1 KTIAVVGAspnpGRPGYKVARYLLEHGYPVIPV--NP-KAKEILG------------EPVYPSLADPPEpvDLVDVFRPP 65

                          90       100
                  ....*....|....*....|..
gi 491603021   80 DVNASILATLIAKeaGVKSVWV 101
Cdd:pfam13380  66 EAVPEIVEEALAL--GAKAVWL 85
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 156-215 4.26e-03

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 37.80  E-value: 4.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021 156 VVGSRLMGKTLSDLALCKVEGVQVLGFKRGPEIIkAPDMSTTLEIGDLIIVVGPQDKLAN 215
Cdd:COG2985  209 VTNPNLVGKTVAELEALLGTRVVISRIRRGGEII-VPTPDTVLQEGDIVLVVGTREALEA 267
2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_ cd08255
2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; This subgroup ...
 4-91 5.53e-03

2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; This subgroup of the medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family has members identified as 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase and alcohol dehydrogenases. The medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family, which contains the zinc-dependent alcohol dehydrogenase (ADH-Zn) and related proteins, is a diverse group of proteins related to the first identified member, class I mammalian ADH. MDRs display a broad range of activities and are distinguished from the smaller short chain dehydrogenases (~ 250 amino acids vs. the ~ 350 amino acids of the MDR). The MDR proteins have 2 domains: a C-terminal NAD(P) binding-Rossmann fold domain of a beta-alpha form and an N-terminal catalytic domain with distant homology to GroES. The MDR group contains a host of activities, including the founding alcohol dehydrogenase (ADH), quinone reductase, sorbitol dehydrogenase, formaldehyde dehydrogenase, butanediol DH, ketose reductase, cinnamyl reductase, and numerous others. The zinc-dependent alcohol dehydrogenases (ADHs) catalyze the NAD(P)(H)-dependent interconversion of alcohols to aldehydes or ketones. Active site zinc has a catalytic role, while structural zinc aids in stability.


Pssm-ID: 176217 [Multi-domain]  Cd Length: 277  Bit Score: 36.86  E-value: 5.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491603021   4 GDKqFAVIGLGRFGLAVCKELQDSG-SQVLAVDINEDRVKEAAGFVSqaivANCTHEETVAELKLDDYDMVMIAIGadvN 82
Cdd:cd08255   98 GER-VAVVGLGLVGLLAAQLAKAAGaREVVGVDPDAARRELAEALGP----ADPVAADTADEIGGRGADVVIEASG---S 169


                 ....*....
gi 491603021  83 ASILATLIA 91
Cdd:cd08255  170 PSALETALR 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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