|
Name |
Accession |
Description |
Interval |
E-value |
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
6-466 |
0e+00 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 771.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 6 IKLPKINSLYGRIFAIFWFTMLLVLIAVLSLPHLDPRKARDIPDEHYQRIIETRDAIQNKYSKETDLGRILFRVEGNRAG 85
Cdd:PRK09470 1 KRLPMINSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQRQGLMIEQHIEAELANDPPNDLMWWRRLFRAID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 86 KHDPRP-RVFFSDYNGNVLTTDKRsnfQLRAMQNFVTSIEDYNKPKQRLYGRYMIAGPVPIVLADSELLMYVGFKWNEPP 164
Cdd:PRK09470 81 KWAPPGqRLLLVTSEGRIIGAERS---EMQAVRNFIGQSDNADHPQKKKYGRVEIVGPFSVRDGEDNYQLYLIRPANSPQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 165 P-LLLRLFDHPFQLLLAVMLVSTPLLLWLAWALSQPARRLEAAAQRVAKGEFVIDPNLEKGTAEFRQAGSSFNQMVEAVN 243
Cdd:PRK09470 158 SdFINLLFDRPLLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELETGPQEFRQAGASFNQMVTALE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 244 QMISGQQRLLSDISHELRSPLTRLRMASALATRKQGDSPELVRIDTEAQRLEQMISELLELSRMQVNSHMTRETQPIESL 323
Cdd:PRK09470 238 RMMTSQQRLLSDISHELRTPLTRLQLATALLRRRQGESKELERIETEAQRLDSMINDLLVLSRNQQKNHLERETFKANSL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 324 WEEIIKDAQFEAEQMGKTLRYSEIPER-HISGNPKLLMSAVENIIRNAIYYGKDEVQIDIQDKTDTLTITVDDNGDGVPD 402
Cdd:PRK09470 318 WSEVLEDAKFEAEQMGKSLTVSAPPGPwPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPE 397
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491621032 403 EELEAIFRPFYRVSTARDRHSGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPLVKVG 466
Cdd:PRK09470 398 EEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKRS 461
|
|
| CpxA_peri |
pfam16527 |
Two-component sensor protein CpxA, periplasmic domain; CpxA_peri is the periplasmic ... |
41-172 |
5.54e-76 |
|
Two-component sensor protein CpxA, periplasmic domain; CpxA_peri is the periplasmic domain-family of the Gram-negative Gammaproteobacteria two-component signalling system, Cpx. It represents the recognition-site for sensing specific envelope stress signals. The fold that the domain-core of CpxA_peri conforms to is a PAS fold. The domain senses the environmental change and triggers a signal transduction to the cytoplasmic domain. As well as the PAS-core, there is a C-terminal tail that is necessary for ligand-sensing and binding to CpxP, a CpxA-associated and a regulatory protein. This domain recognizes KCl and RbCl (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 435400 [Multi-domain] Cd Length: 134 Bit Score: 233.85 E-value: 5.54e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 41 PRKARDIPDEHYQRIIETRDAIQNKYSKETDLGRILFRVEG--NRAGKHDPRPRVFFSDYNGNVLTTDKRSNFQLRAMQN 118
Cdd:pfam16527 1 PRKQRDIPAEHLQRLLESADDIESRYSEESNLKKILFRLEGpdNRHRKHDGRPRFFFTDYEGEILTTKRRSDFRLKALRN 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 491621032 119 FVTSIEDYNKPKQRLYGRYMIAGPVPIVLADSELLMYVGFKWNEPPPLLLRLFD 172
Cdd:pfam16527 81 FVTSIEDPQKPQQKLYGRYMMAGPVPITLADQTLLMYVGRKWNEPPPFLLRLFD 134
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
145-464 |
1.57e-57 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 194.77 E-value: 1.57e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 145 IVLADSELLMYVGFKWNEPPPLLLRLFDHPFQLLLAVMLVSTPLLLWLAWALSQPARRLEAAAQRVAKGEFVIDPNLEKG 224
Cdd:COG5002 54 LLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGR 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 225 TAEFRQAGSSFNQMVEAVNQMISGQQRL-------LSDISHELRSPLTRLRMASALATRKQGDSPELVR-----IDTEAQ 292
Cdd:COG5002 134 LSLRLSALLLGLLLLAAVERDITELERLeqmrrefVANVSHELRTPLTSIRGYLELLLDGAADDPEERReyleiILEEAE 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 293 RLEQMISELLELSRMQVNSH-MTRETQPIESLWEEIIKDAQFEAEQMGKTLRYSEIPE-RHISGNPKLLMSAVENIIRNA 370
Cdd:COG5002 214 RLSRLVNDLLDLSRLESGELkLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDpLLVLGDPDRLEQVLTNLLDNA 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 371 IYYGKD--EVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITESAIRQHSGTIVASR 448
Cdd:COG5002 294 IKYTPEggTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVES 373
|
330
....*....|....*.
gi 491621032 449 SPLGGLRVSITLPLVK 464
Cdd:COG5002 374 EPGKGTTFTITLPLAR 389
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
236-464 |
1.31e-53 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 179.72 E-value: 1.31e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 236 NQMVEAVNQMisgQQRLLSDISHELRSPLTRLRMASALATRKQGDSPE-----LVRIDTEAQRLEQMISELLELSRMQVN 310
Cdd:COG2205 6 LEELEELERL---KSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEerrelLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 311 S-HMTRETQPIESLWEEIIKDAQFEAEQMGKTLRYSEIPER-HISGNPKLLMSAVENIIRNAIYYGKD--EVQIDIQDKT 386
Cdd:COG2205 83 KlSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELpLVYADPELLEQVLANLLDNAIKYSPPggTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491621032 387 DTLTITVDDNGDGVPDEELEAIFRPFYRVStaRDRHSGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPLVK 464
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAE 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
138-462 |
4.59e-51 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 175.87 E-value: 4.59e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 138 MIAGPVPIVLADSELLMYVGFKWNEPPPLLLRLFDHPFQLLLAVMLVSTPLLLWLAWALSQPARRLEAAAQRVAKGEFVI 217
Cdd:COG0642 2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 218 DPNLEKGTAEFRQAGSSFNQMVEAVNQMISgqqRLLSDISHELRSPLTRLRMASALATRKQGDSPE--LVRIDTEAQRLE 295
Cdd:COG0642 82 LLLLLLLLLLLLLLLLALLLLLEEANEAKS---RFLANVSHELRTPLTAIRGYLELLLEELDEEQReyLETILRSADRLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 296 QMISELLELSRMQvNSHMTRETQPIE--SLWEEIIKDAQFEAEQMGKTLRYsEIPE--RHISGNPKLLMSAVENIIRNAI 371
Cdd:COG0642 159 RLINDLLDLSRLE-AGKLELEPEPVDlaELLEEVVELFRPLAEEKGIELEL-DLPDdlPTVRGDPDRLRQVLLNLLSNAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 372 YYGKD--EVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTArdRHSGGTGLGLTITESAIRQHSGTIVASRS 449
Cdd:COG0642 237 KYTPEggTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVESE 314
|
330
....*....|...
gi 491621032 450 PLGGLRVSITLPL 462
Cdd:COG0642 315 PGKGTTFTVTLPL 327
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-462 |
1.27e-45 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 154.02 E-value: 1.27e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 359 LMSAVENIIRNAIYYGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITESAIR 438
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 491621032 439 QHSGTIVASRSPLGGLRVSITLPL 462
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
198-462 |
1.47e-42 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 155.92 E-value: 1.47e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 198 QPARRLEAAAQRVAKGEFVIDPNLEKGTAEFRqAGSSFNQMVEAVNQMISGQQRLLSDISHELRSPLTRLRMAsaLATRK 277
Cdd:PRK10604 162 QDMLKLEAAAQRLGDGHLAERIHFDEGSSLER-LGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYR--LEMSD 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 278 QGDSPELVRIDTEAQRLEQMISELL---ELSRMQVNSHmtreTQPIE-SLW-EEIIKDAQfeaeqmgkTLRyseiPERHI 352
Cdd:PRK10604 239 NLSAAESQALNRDIGQLEALIEELLtyaRLDRPQNELH----LSEPDlPAWlSTHLADIQ--------AVT----PEKTV 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 353 S-----------GNPKLLMSAVENIIRNAIYYGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDR 421
Cdd:PRK10604 303 RldtphqgdygaLDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDR 382
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 491621032 422 HSGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPL 462
Cdd:PRK10604 383 ATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
199-463 |
4.72e-41 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 151.99 E-value: 4.72e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 199 PARRLEAAAQRVAKGEFViDPNLEKGTAEFRQAGSSFNQMVEAVNQMISGQQRLLSDISHELRSPLTRLRMASALATRKQ 278
Cdd:PRK09467 180 PLVALEHAALQVGKGEIP-PPLREYGASEVRSVTRAFNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEMMSEED 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 279 GDSPELVRIDTEaqRLEQMISELLELSRmQVNShMTRETQPIESLWEEIIkdaQFEAEQMGK-TLRYSEIPERhISGNPK 357
Cdd:PRK09467 259 GYLAESINKDIE--ECNAIIEQFIDYLR-TGQE-MPMEMADLNALLGEVI---AAESGYEREiETALQPGPIE-VPMNPI 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 358 LLMSAVENIIRNAIYYGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDrhSGGTGLGLTITESAI 437
Cdd:PRK09467 331 AIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARG--SSGTGLGLAIVKRIV 408
|
250 260
....*....|....*....|....*.
gi 491621032 438 RQHSGTIVASRSPLGGLRVSITLPLV 463
Cdd:PRK09467 409 DQHNGKVELGNSEEGGLSARAWLPLT 434
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
198-463 |
2.29e-37 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 143.24 E-value: 2.29e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 198 QPARRLEAAAQRVAKGefvidpNL-----EKGTAEFRQAGSSFNQMVEAVNQMISG-------QQRLLSDISHELRSPLT 265
Cdd:NF040691 214 APVRSAARTAERFAAG------DLsermpVKGEDDLARLARSFNQMADSLQRQIRQleelsrlQQRFVSDVSHELRTPLT 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 266 RLRMASAL----------ATRKqgdSPELVRidTEAQRLEQMISELLELSRMQVNSHM-TRETQPIESLWEEIIKDAQFE 334
Cdd:NF040691 288 TIRMAADVihdsrddfdpATAR---SAELLH--TELDRFESLLSDLLEISRFDAGAAElDVEPVDLRPLVRRVVDALRQL 362
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 335 AEQMGKTLRYsEIPERHI--SGNPKLLMSAVENIIRNAIYYGKDE-VQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRP 411
Cdd:NF040691 363 AERAGVELRV-DAPGTPVvaEVDPRRVERVLRNLVVNAIEHGEGKpVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDR 441
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 491621032 412 FYRVSTARDRHSGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPLV 463
Cdd:NF040691 442 FWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLTLPRV 493
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
197-462 |
1.78e-33 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 131.51 E-value: 1.78e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 197 SQPARRLEAAAQRVAKGEFVIDPNLekGTAEFRQAGSSFNQMVEAVN--QMISGQQRLLSdisHELRSPLTRLRMASALA 274
Cdd:PRK11100 207 NRSIRRLTRYADAVTEGKPVPLPKL--GSSELRELAQALESMRVKLEgkAYVEQYVQTLT---HELKSPLAAIRGAAELL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 275 trkQGDSPELVR------IDTEAQRLEQMISELLELSRM-QVNSHMTRETQPIESLWEEIIKDAQFEAEQMGKTLRYsEI 347
Cdd:PRK11100 282 ---QEDPPPEDRarftgnILTQSARLQQLIDRLLELARLeQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRL-RP 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 348 PERHISGNPKLLMSAVENIIRNAIYYG--KDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYrvSTARDrHSG- 424
Cdd:PRK11100 358 DDARVLGDPFLLRQALGNLLDNAIDFSpeGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFY--SLPRP-ANGr 434
|
250 260 270
....*....|....*....|....*....|....*....
gi 491621032 425 -GTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPL 462
Cdd:PRK11100 435 kSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
199-461 |
1.36e-30 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 123.27 E-value: 1.36e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 199 PARRLEAAAQRVAKGEFVIDPNLEKGTAEFRQAGSSFNQMVEAVNQMISGQQRLLSDISHELRSPLTRLRMASALATRKQ 278
Cdd:TIGR01386 191 PLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQP 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 279 GDSPELVRI----DTEAQRLEQMISELLELSRM-QVNSHMTRETQpieSLWEEIIKDAQ-FE--AEQMGKTLRYSEipER 350
Cdd:TIGR01386 271 RTGEEYREVlesnLEELERLSRMVSDMLFLARAdNGQLALERVRL---DLAAELAKVAEyFEplAEERGVRIRVEG--EG 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 351 HISGNPKLLMSAVENIIRNAIYYGKDEVQIDIQ--DKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGL 428
Cdd:TIGR01386 346 LVRGDPQMFRRAISNLLSNALRHTPDGGTITVRieRRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGL 425
|
250 260 270
....*....|....*....|....*....|...
gi 491621032 429 GLTITESAIRQHSGTIVASrSPLGGLRVSITLP 461
Cdd:TIGR01386 426 GLAIVRSIMEAHGGRASAE-SPDGKTRFILRFP 457
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
256-461 |
1.69e-30 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 123.74 E-value: 1.69e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 256 ISHELRSPLTRLRMASALATRKQGDSPE------LVRIDTEAQRLEQMISELLELSRMQvNSHMTRETQPIESLWEEIIK 329
Cdd:COG4251 289 ASHDLREPLRKISGFSQLLEEDYGDKLDeegreyLERIRDAAERMQALIDDLLAYSRVG-RQELEFEPVDLNELLEEVLE 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 330 DAQFEAEQMGKTLRYSEIPErhISGNPKLLMSAVENIIRNAIYYGKD----EVQIDIQDKTDTLTITVDDNGDGVPDEEL 405
Cdd:COG4251 368 DLEPRIEERGAEIEVGPLPT--VRGDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEYA 445
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 491621032 406 EAIFRPFYRVSTARDRhsGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLP 461
Cdd:COG4251 446 EKIFEIFQRLHSRDEY--EGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
250-464 |
2.62e-30 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 121.99 E-value: 2.62e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 250 QRLLSDISHELRSPLT--RL---RMASALATRKQGDSPELVR----IDTEAQRLEQMISELLELSRMqvnSHMTRETQPI 320
Cdd:COG5000 202 GELARRIAHEIKNPLTpiQLsaeRLRRKLADKLEEDREDLERaldtIIRQVDRLKRIVDEFLDFARL---PEPQLEPVDL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 321 ESLWEEIIKDAQFEAEQMGKTLRYS-EIPERHISGNPKLLMSAVENIIRNAIYYGKD--EVQIDIQDKTDTLTITVDDNG 397
Cdd:COG5000 279 NELLREVLALYEPALKEKDIRLELDlDPDLPEVLADRDQLEQVLINLLKNAIEAIEEggEIEVSTRREDGRVRIEVSDNG 358
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491621032 398 DGVPDEELEAIFRPFYrvSTardrHSGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPLVK 464
Cdd:COG5000 359 PGIPEEVLERIFEPFF--TT----KPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRLPLAE 419
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
199-464 |
4.22e-29 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 118.97 E-value: 4.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 199 PARRLEAAAQRVAKGEFV--IDPNlekGTAEFRQAGSSFNQMVEAVNQMISGQQRLLSDISHELRSPLTRLR-MASALAT 275
Cdd:PRK10549 191 PVKRLVEGTHKLAAGDFTtrVTPT---SRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRgELEAIQD 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 276 RKQGDSPE-LVRIDTEAQRLEQMISELLELSRMQVNSHMTRETqPIESLweEIIKDA------QFEAEQMGKTLRYSEip 348
Cdd:PRK10549 268 GVRKFTPEsVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKT-PVDLV--PLLEVAggafreRFASRGLTLQLSLPD-- 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 349 ERHISGNPKLLMSAVENIIRNAIYYGKDEVQIDIQDKTD--TLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGT 426
Cdd:PRK10549 343 SATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRdkTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGS 422
|
250 260 270
....*....|....*....|....*....|....*...
gi 491621032 427 GLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPLVK 464
Cdd:PRK10549 423 GLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLER 460
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
240-464 |
9.41e-29 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 116.48 E-value: 9.41e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 240 EAVNQMISGqqrllsdISHELRSPLTRLRMASALATRKQGDSP--ELVR-IDTEAQRLEQMISELLELSRmqvNSHMTRE 316
Cdd:COG3852 133 AAVGELAAG-------LAHEIRNPLTGIRGAAQLLERELPDDElrEYTQlIIEEADRLNNLVDRLLSFSR---PRPPERE 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 317 TQPIESLWEEIIKDAQFEAEQmGKTLRY---SEIPErhISGNPKLLMSAVENIIRNAIYYGKDE------------VQID 381
Cdd:COG3852 203 PVNLHEVLERVLELLRAEAPK-NIRIVRdydPSLPE--VLGDPDQLIQVLLNLVRNAAEAMPEGgtitirtrverqVTLG 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 382 IQDKTDTLTITVDDNGDGVPDEELEAIFRPFYrvsTARDrhsGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLP 461
Cdd:COG3852 280 GLRPRLYVRIEVIDNGPGIPEEILDRIFEPFF---TTKE---KGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
...
gi 491621032 462 LVK 464
Cdd:COG3852 354 LEQ 356
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
354-462 |
3.05e-27 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 105.04 E-value: 3.05e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 354 GNPKLLMSAVENIIRNAIYYGKDEVQIDIQ--DKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTaRDRHSGGTGLGLT 431
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTleRDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 491621032 432 ITESAIRQHSGTIVASRSPLGGLRVSITLPL 462
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
355-461 |
1.69e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 102.93 E-value: 1.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 355 NPKLLMSAVENIIRNAIYY----GKdeVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGL 430
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYtdtgGK--LRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGL 78
|
90 100 110
....*....|....*....|....*....|.
gi 491621032 431 TITESAIRQHSGTIVASRSPLGGLRVSITLP 461
Cdd:cd16946 79 AICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
227-461 |
2.11e-26 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 111.40 E-value: 2.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 227 EFRQAGSSFNQMVEAVNQMISGQQRLLSDISHELRSPLTRLRMASALA---TRKQGDSPELVRIDTEA-QRLEQMISELL 302
Cdd:PRK09835 240 ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIAlsqSRSQKELEDVLYSNLEElTRMAKMVSDML 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 303 ELSRMQvNSHMTRETQPIEsLWEEIIKDAQF---EAEQMGKTLRYSEIPERhISGNPKLLMSAVENIIRNAIYYGKD--E 377
Cdd:PRK09835 320 FLAQAD-NNQLIPEKKMLD-LADEVGKVFDFfeaWAEERGVELRFVGDPCQ-VAGDPLMLRRAISNLLSNALRYTPAgeA 396
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 378 VQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITESAIRQHSGTiVASRSPLGGLRVS 457
Cdd:PRK09835 397 ITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGT-VAVTSDARGTRFV 475
|
....
gi 491621032 458 ITLP 461
Cdd:PRK09835 476 ISLP 479
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
359-460 |
3.12e-26 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 101.91 E-value: 3.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 359 LMSAVENIIRNAIYYGKD--EVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTArdRHSGGTGLGLTITESA 436
Cdd:cd00075 1 LEQVLSNLLDNALKYSPPggTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKS--REGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 491621032 437 IRQHSGTIVASRSPLGGLRVSITL 460
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
139-463 |
4.02e-26 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 108.73 E-value: 4.02e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 139 IAGPVPIVLADSELLMYVGFKWNEPPPLLLRLFDHPFQLLLAVMLVSTPLLLWLAWALSQPARRLEAAAQRVAKgefvid 218
Cdd:COG4191 45 ALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITE------ 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 219 pnLEKGTAEFRQAGSsfnQMV-----EAVNQMISGqqrllsdISHELRSPLTRLRMASALATRKQGDSPE-------LVR 286
Cdd:COG4191 119 --LERAEEELRELQE---QLVqseklAALGELAAG-------IAHEINNPLAAILGNAELLRRRLEDEPDpeelreaLER 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 287 IDTEAQRLEQMISELLELSRmqvNSHMTRETQPIESLWEEIIKDAQFEAEQMGKTLRY---SEIPErhISGNPKLLMSAV 363
Cdd:COG4191 187 ILEGAERAAEIVRSLRAFSR---RDEEEREPVDLNELIDEALELLRPRLKARGIEVELdlpPDLPP--VLGDPGQLEQVL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 364 ENIIRNAIY----YGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYrvSTarDRHSGGTGLGLTITESAIRQ 439
Cdd:COG4191 262 LNLLINAIDameeGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF--TT--KPVGKGTGLGLSISYGIVEK 337
|
330 340
....*....|....*....|....
gi 491621032 440 HSGTIVASRSPLGGLRVSITLPLV 463
Cdd:COG4191 338 HGGRIEVESEPGGGTTFTITLPLA 361
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-462 |
8.53e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 98.27 E-value: 8.53e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 362 AVENIIRNAIYYGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITESAIRQHS 441
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWHG 83
|
90 100
....*....|....*....|.
gi 491621032 442 GTIVASRSPLGGLRVSITLPL 462
Cdd:cd16939 84 GHVECDDSELGGACFRLTWPR 104
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
170-459 |
3.28e-24 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 104.73 E-value: 3.28e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 170 LFDHPFQLLLAVMLVStplllwlawALSQPARRLEAA-AQRVAKGEfviDP-NLEKGTAEFRQAGSSFNQMVEAVNQMIS 247
Cdd:PRK10337 168 LVALPIMLIILMVLLG---------RELAPLKKLALAlRMRDPDSE---TPlNATGVPSEVRPLVEALNQLFARTHAMMV 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 248 GQQRLLSDISHELRSPLTRLRMASALATRKQgDSPE-----LVRIDTEAQRLEQMISELLELSRMQVNSHMtRETQPIEs 322
Cdd:PRK10337 236 RERRFTSDAAHELRSPLAALKVQTEVAQLSD-DDPQarkkaLLQLHAGIDRATRLVDQLLTLSRLDSLDNL-QDVAEIP- 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 323 lWEEIIKDAQFE----AEQMGKTLRYsEIPERHI--SGNPKLLMSAVENIIRNAIYYGKDEVQIDIqdktdTLT---ITV 393
Cdd:PRK10337 313 -LEDLLQSAVMDiyhtAQQAGIDVRL-TLNAHPVirTGQPLLLSLLVRNLLDNAIRYSPQGSVVDV-----TLNarnFTV 385
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491621032 394 DDNGDGVPDEELEAIFRPFYRvstARDRHSGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSIT 459
Cdd:PRK10337 386 RDNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
354-462 |
5.41e-24 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 96.28 E-value: 5.41e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 354 GNPKLLMSAVENIIRNAIYYGKDEVQIDIQ-DKTDTLTITVDDNGDGVPDEELEAIFRPFYRvstARDRHSGGTGLGLTI 432
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTlSEGGELTLTVEDNGIGIPPEDLPRIFEPFST---ADKRGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|
gi 491621032 433 TESAIRQHSGTIVASRSPLGGLRVSITLPL 462
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
225-461 |
2.43e-21 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 95.85 E-value: 2.43e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 225 TAEFRQAGSSFNQM---VEAVNQM--ISGQQR-LLSDISHELRSPLTRLR----------MASALATRKQGDSPElvrid 288
Cdd:PRK11006 174 HLEIRVMPYTEGQLlmvARDVTQMhqLEGARRnFFANVSHELRTPLTVLQgylemmqdqpLEGALREKALHTMRE----- 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 289 tEAQRLEQMISELLELSRMQVN-SHMTRETQPIESLWEEIIKDAQFEAEQMgKTLRYSEIPERHISGNPKLLMSAVENII 367
Cdd:PRK11006 249 -QTQRMEGLVKQLLTLSKIEAApTIDLNEKVDVPMMLRVLEREAQTLSQGK-HTITFEVDNSLKVFGNEDQLRSAISNLV 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 368 RNAIYYGKDEVQIDI--QDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITESAIRQHSGTIV 445
Cdd:PRK11006 327 YNAVNHTPEGTHITVrwQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLE 406
|
250
....*....|....*.
gi 491621032 446 ASRSPLGGLRVSITLP 461
Cdd:PRK11006 407 IESEVGKGTRFSFVLP 422
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-461 |
1.31e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 83.65 E-value: 1.31e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 362 AVENIIRNAIYYGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDrhSGGTGLGLTITESAIRQHS 441
Cdd:cd16950 4 VLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISDAHG 81
|
90 100
....*....|....*....|
gi 491621032 442 GTIVASRSPLGGLRVSITLP 461
Cdd:cd16950 82 GSLTLANRAGGGLCARIELP 101
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
246-463 |
1.93e-19 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 90.56 E-value: 1.93e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 246 ISGQqrLLSDISHELRSPLTRLRMASALATRKQGDSPELVRI-DTEAQRLEQMISELLELSRMQVNShmtRETQPIESLW 324
Cdd:COG5805 286 IAGQ--LAAGIAHEIRNPLTSIKGFLQLLQPGIEDKEEYFDImLSELDRIESIISEFLALAKPQAVN---KEKENINELI 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 325 EEIIKDAQFEAEQMGKTLRYS---EIPErhISGNPKLLMSAVENIIRNAIYYGKDEVQIDIQDKT--DTLTITVDDNGDG 399
Cdd:COG5805 361 QDVVTLLETEAILHNIQIRLElldEDPF--IYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEedNSVIIRVIDEGIG 438
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491621032 400 VPDEELEAIFRPFYrvsTARDRhsgGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPLV 463
Cdd:COG5805 439 IPEERLKKLGEPFF---TTKEK---GTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPLS 496
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
251-464 |
1.54e-18 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 87.72 E-value: 1.54e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 251 RLLSDISHELRSPLTRLR-MASALATRKQGDSPELVRI-DTEAQRLEQMISELLELSRMQvNSHMtrETQPIESLWEEII 328
Cdd:COG5809 272 ELAAGIAHEIRNPLTSLKgFIQLLKDTIDEEQKTYLDImLSELDRIESIISEFLVLAKPQ-AIKY--EPKDLNTLIEEVI 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 329 ---------KDAQFEAEQMGKtlryseIPErhISGNPKLLMSAVENIIRNAIYYGKD--EVQIDIQDKTDT-LTITVDDN 396
Cdd:COG5809 349 pllqpqallKNVQIELELEDD------IPD--ILGDENQLKQVFINLLKNAIEAMPEggNITIETKAEDDDkVVISVTDE 420
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491621032 397 GDGVPDEELEAIFRPFYrvsTARDRhsgGTGLGLTITESAIRQHSGTIVASrSPLG-GLRVSITLPLVK 464
Cdd:COG5809 421 GCGIPEERLKKLGEPFY---TTKEK---GTGLGLMVSYKIIEEHGGKITVE-SEVGkGTTFSITLPIKL 482
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
233-461 |
2.35e-17 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 83.09 E-value: 2.35e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 233 SSFNQMVEAVNQMISgQQRLL-SDISHELRSPLTRLRMASALaTRKQG--DSPELVridteaQRLEQM---ISELLELSR 306
Cdd:PRK10755 121 SALNQLVSRLTSTLD-QERLFtADVAHELRTPLAGIRLHLEL-LEKQHhiDVAPLI------ARLDQMmhtVEQLLQLAR 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 307 mqVNSHMTRETQPIESLWEEIIKDAQFEAEQM----GKTLRYSEIP-ERHISGNPKLLMSAVENIIRNAIYYGKDEVQID 381
Cdd:PRK10755 193 --AGQSFSSGHYQTVKLLEDVILPSQDELSEMleqrQQTLLLPESAaDITVQGDATLLRLLLRNLVENAHRYSPEGSTIT 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 382 IQ--DKTDTLTITVDDNGDGVPDEELEAIFRPFYRVstarDRHSGGTGLGLTITESAIRQHSGT-IVASRSPLGGLRVSI 458
Cdd:PRK10755 271 IKlsQEDGGAVLAVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSIVSRITQLHHGQfFLQNRQERSGTRAWV 346
|
...
gi 491621032 459 TLP 461
Cdd:PRK10755 347 WLP 349
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
252-462 |
3.88e-17 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 83.30 E-value: 3.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 252 LLSDISHELRSPLTRLR-MASALATR--KQGDSPELVRI-DTEAQRLEQMISELLELSRmqvNSHMTRETQPIESLWEEI 327
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKgLAKYFAERapAGGEAHQLAQVmAKEADRLNRVVSELLELVK---PTHLALQAVDLNDLINHS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 328 IKDAQFEAEQMGKTLRYSEIPE-RHISGNPKLLMSAVENIIRNAIY-YGKDEV-QIDIQDKTDTLTITVDDNGDGVPDEE 404
Cdd:PRK10364 317 LQLVSQDANSREIQLRFTANDTlPEIQADPDRLTQVLLNLYLNAIQaIGQHGViSVTASESGAGVKISVTDSGKGIAADQ 396
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 491621032 405 LEAIFRPFYrvSTARDrhsgGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPL 462
Cdd:PRK10364 397 LEAIFTPYF--TTKAE----GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPV 448
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
354-460 |
4.10e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 77.06 E-value: 4.10e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 354 GNPKLLMSAVENIIRNAIYYGKDEVQIDI-QDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTardRHSGGTGLGLTI 432
Cdd:cd16940 9 GDALLLFLLLRNLVDNAVRYSPQGSRVEIkLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGLGLSI 85
|
90 100
....*....|....*....|....*...
gi 491621032 433 TESAIRQHSGTIVASRSPLGGLRVSITL 460
Cdd:cd16940 86 VKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
252-465 |
1.11e-16 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 82.78 E-value: 1.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 252 LLSDISHELRSPLTRLrMASA------LATRKQGDSPELVRIDTEAQRLEQMISELLELSRMQVNS-HMTRETQPIEslw 324
Cdd:PRK10490 667 LLAALSHDLRTPLTVL-FGQAeiltldLASEGSPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGfNLRKEWLTLE--- 742
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 325 eEIIKDA--QFEAEQMGKTLRYS---EIPERHISGNpkLLMSAVENIIRNAIYYGKDEVQIDIQDKT--DTLTITVDDNG 397
Cdd:PRK10490 743 -EVVGSAlqMLEPGLSGHPINLSlpePLTLIHVDGP--LFERVLINLLENAVKYAGAQAEIGIDAHVegERLQLDVWDNG 819
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 398 DGVPDEELEAIFRPFYRVstarDRHSG--GTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPLVKV 465
Cdd:PRK10490 820 PGIPPGQEQLIFDKFARG----NKESAipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLETP 885
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
251-467 |
1.32e-16 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 82.32 E-value: 1.32e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 251 RLLSDISHELRSPLTRLRmASALATRKQGDSPE----LVRIDTEAQRLEQMISELLELSRmqvnshmtretqPIESLWE- 325
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIR-GYVQIWRQQTSDPPsqeyLSVVLREVDRLNKVIDQLLEFSR------------PRESQWQp 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 326 ----EIIKDA-QFEAEQMGK-----TLRY-SEIPErhISGNPKLLMSAVENIIRNAIYY--GKDEVQIDI-QDKTDTLTI 391
Cdd:PRK11360 459 vslnALVEEVlQLFQTAGVQarvdfETELdNELPP--IWADPELLKQVLLNILINAVQAisARGKIRIRTwQYSDGQVAV 536
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491621032 392 TVDDNGDGVPDEELEAIFRPFYrvsTARDRhsgGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPLVKVGK 467
Cdd:PRK11360 537 SIEDNGCGIDPELLKKIFDPFF---TTKAK---GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGN 606
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
253-459 |
1.40e-16 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 81.99 E-value: 1.40e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 253 LSDISHELRSPL----TRLRmasALATRKQGDSPELVRIDTEA-QRLEQMISELLELSRMQVNSH-MTRETQPIESLWEE 326
Cdd:PRK10815 270 LTDLTHSLKTPLavlqSTLR---SLRSGKQMSVEQAEPIMLEQiSRISQQIGYYLHRASMRSEHNlLSRELHSVAPLLDN 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 327 IIKDAQFEAEQMGKTLRYSEIPERHISGNPKLLMSAVENIIRNAIYYGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELE 406
Cdd:PRK10815 347 LTSALNKVYQRKGVNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRE 426
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 491621032 407 AIFRPFYRVSTARDrhsgGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSIT 459
Cdd:PRK10815 427 LIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGGARMEVI 475
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
256-463 |
3.29e-16 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 80.30 E-value: 3.29e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 256 ISHELRSPLTRLR-----MASALATRKQGDspELVRID-TEAQRLEQMISELLELSRMQVNSHmtrETQPIESLWEEIIK 329
Cdd:COG5806 208 IAHEVRNPLTVVRgfiqlLQEPELSDEKRK--QYIRIAlEELDRAEAIITDYLTFAKPQPEKL---EKIDVSEELEHVID 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 330 DAQFEAEQMGKTLRYSEIPERHISGNPKLLMSAVENIIRNAIYYGKD--EVQIDIQDKTDTLTITVDDNGDGVPDEELEA 407
Cdd:COG5806 283 VLSPYANMNNVEIQTELEPGLYIEGDRQKLQQCLINIIKNGIEAMPNggTLTIDVSIDKNKVIISIKDTGVGMTKEQLER 362
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 491621032 408 IFRPFYrvSTARDrhsgGTGLGLTITESAIRQHSGTI-VASRspLG-GLRVSITLPLV 463
Cdd:COG5806 363 LGEPYF--STKEK----GTGLGTMVSYRIIEAMNGTIrVESE--VGkGTTFTITLPLA 412
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
175-464 |
4.70e-16 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 80.06 E-value: 4.70e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 175 FQLLLAVMLVSTPLLLWLAWALSQPARRLEAAAQRVAKGEFVIDPnlEKGTAEFRQAGSSFNQMVEAVNQMISGQQRLls 254
Cdd:COG2972 160 LLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLE--VSGNDEIGILARSFNEMVERIKELIEEVYEL-- 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 255 dishELRspLTRLRMAsALATRKQgdsP-----------ELVRIDtEAQRLEQMISELLELSRMQVNShmTRETQPIEsl 323
Cdd:COG2972 236 ----ELE--KKEAELK-ALQAQIN---PhflfntlnsirWLAELE-DPEEAEEMLEALSKLLRYSLSK--GDELVTLE-- 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 324 wEEI--IKDaQFEAEQM--GKTLRYS-EIPERHISGN-PKLLMSaveNIIRNAIYYG------KDEVQIDIQDKTDTLTI 391
Cdd:COG2972 301 -EELelIKS-YLEIQKLrfGDRLEVEiEIDEELLDLLiPKLILQ---PLVENAIEHGiepkegGGTIRISIRKEGDRLVI 375
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491621032 392 TVDDNGDGVPDEELEAIFRPFyrvstarDRHSGGTGLGLTITESAIRQHSG---TIVASRSPLGGLRVSITLPLVK 464
Cdd:COG2972 376 TVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGeeyGLEIESEPGEGTTVTIRIPLEE 444
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-447 |
4.83e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 73.57 E-value: 4.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 364 ENIIRNAIYYGKDE--VQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTArdRHSGGTGLGLTITESAIRQHS 441
Cdd:cd16923 6 SNLLSNAIKYSPENtrIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNS--RNTEGAGLGLSIAKAIIELHG 83
|
....*.
gi 491621032 442 GTIVAS 447
Cdd:cd16923 84 GSASAE 89
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
345-464 |
6.42e-16 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 79.12 E-value: 6.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 345 SEIPERHISgnPKLLMSAVENIIRNAIYYGKD------EVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPfyRVSTa 418
Cdd:COG3290 270 SDLPDLPLS--DTDLVTILGNLLDNAIEAVEKlpeeerRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFER--GFST- 344
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 491621032 419 rdRHSGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPLVK 464
Cdd:COG3290 345 --KLGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
220-462 |
6.98e-16 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 80.46 E-value: 6.98e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 220 NLEKGTAEFRQAGSSFNQMVEAVNQMISgqqRLLSDISHELRSPLTRLRMASALATRKQGDSPELVRIDTEAQ---RLEQ 296
Cdd:PRK15347 372 TLENKVAERTQALAEAKQRAEQANKRKS---EHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARQctlSLLA 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 297 MISELLELSRM---QVNSHMtrETQPIESLWEEIIKDAQFEAEQMGKTLRY---SEIPErhisgnpKLLMSAVE------ 364
Cdd:PRK15347 449 IINNLLDFSRIesgQMTLSL--EETALLPLLDQAMLTIQGPAQSKSLTLRTfvgAHVPL-------YLHLDSLRlrqilv 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 365 NIIRNAIYYGKD-EVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTardrHSGGTGLGLTITESAIRQHSGT 443
Cdd:PRK15347 520 NLLGNAVKFTETgGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGE 595
|
250
....*....|....*....
gi 491621032 444 IVASRSPLGGLRVSITLPL 462
Cdd:PRK15347 596 LTLFSTPGVGSCFSLVLPL 614
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-462 |
8.48e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 72.84 E-value: 8.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 356 PKLLMSAVENIIRNAIYY--GKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDrhsgGTGLGLTIT 433
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAmeGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLS 76
|
90 100
....*....|....*....|....*....
gi 491621032 434 ESAIRQHSGTIVASRSPLGGLRVSITLPL 462
Cdd:cd16943 77 YRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
348-460 |
2.10e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 72.66 E-value: 2.10e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 348 PERHISGNPKLLMSAVENIIRNAIYYGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVstarDRHSGGTG 427
Cdd:cd16954 27 PELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRL----DEQRPGQG 102
|
90 100 110
....*....|....*....|....*....|...
gi 491621032 428 LGLTITESAIRQHSGTIVASRSPLGGLRVSITL 460
Cdd:cd16954 103 LGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
380-462 |
5.41e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 70.98 E-value: 5.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 380 IDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSIT 459
Cdd:cd16922 28 EEEEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKKLVELMGGDISVESEPGQGSTFTFT 107
|
...
gi 491621032 460 LPL 462
Cdd:cd16922 108 LPL 110
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
240-461 |
8.92e-15 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 75.76 E-value: 8.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 240 EAVNQMISGQQRLLSDISHELRSPLTrlrmASALA--TRKQG-------DSPELVR-----IDTEAQRLEQMISELLELS 305
Cdd:PRK09303 142 ETLLEQLKFKDRVLAMLAHDLRTPLT----AASLAleTLELGqidedteLKPALIEqlqdqARRQLEEIERLITDLLEVG 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 306 R-----MQVNShmtRETQpIESLWEEIIKdaQFEAEQMGKTLRY-----SEIPERHisGNPKLLMSAVENIIRNAIYYGK 375
Cdd:PRK09303 218 RtrweaLRFNP---QKLD-LGSLCQEVIL--ELEKRWLAKSLEIqtdipSDLPSVY--ADQERIRQVLLNLLDNAIKYTP 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 376 D--EVQIDIQDKTDT-LTITVDDNGDGVPDEELEAIFRPFYRVStaRDRHSGGTGLGLTITESAIRQHSGTI-VASrSPL 451
Cdd:PRK09303 290 EggTITLSMLHRTTQkVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIVRVHYGQIwVDS-EPG 366
|
250
....*....|
gi 491621032 452 GGLRVSITLP 461
Cdd:PRK09303 367 QGSCFHFTLP 376
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-461 |
2.66e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 68.77 E-value: 2.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 359 LMSAVENIIRNAIYYGKDEVQIDI--QDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITESA 436
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVrwSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 491621032 437 IRQHSGTIVASRSPLGGLRVSITLP 461
Cdd:cd16952 81 MSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-458 |
2.94e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 68.64 E-value: 2.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 358 LLMSAVENIIRNAIYYGKDE--VQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTArdRHSGG-TGLGLTITE 434
Cdd:cd16975 4 LLSRALINIISNACQYAPEGgtVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTS--RRSGGhYGMGLYIAK 81
|
90 100
....*....|....*....|....
gi 491621032 435 SAIRQHSGTIVASRSPLGGLRVSI 458
Cdd:cd16975 82 NLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-461 |
5.29e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 67.74 E-value: 5.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 359 LMSAVENIIRNAIYYGKD----EVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTarDRHSGGTGLGLTITE 434
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPrrppRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 491621032 435 SAIRQHSGTIVASRSPLGGLRVSITLP 461
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
363-461 |
1.52e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 66.75 E-value: 1.52e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 363 VENIIRNAIYYGKDEVQID-IQDKTDT--LTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITESAIRQ 439
Cdd:cd16925 9 VLNLLSNAFKFTPDGGRIRcILEKFRLnrFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEFVEL 88
|
90 100
....*....|....*....|..
gi 491621032 440 HSGTIVASRSPLGGLRVSITLP 461
Cdd:cd16925 89 HGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
227-462 |
9.35e-13 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 70.70 E-value: 9.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 227 EFRQAGSSfnqmVEAVNQMISGqqrLLSDISHELRSPL------TRLRMASALATRKQGDspeLVRIDTEAQRLEQMISE 300
Cdd:PRK11466 429 EHRQARAE----AEKASQAKSA---FLAAMSHEIRTPLygilgtAQLLADNPALNAQRDD---LRAITDSGESLLTILND 498
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 301 LLELSRMQVNSH-MTRETQPIE--SLWEEIIKDAqfEAEQMGKTLR----YSEIPERHISGNPKLLMSAVENIIRNAIYY 373
Cdd:PRK11466 499 ILDYSAIEAGGKnVSVSDEPFEprPLLESTLQLM--SGRVKGRPIRlatdIADDLPTALMGDPRRIRQVITNLLSNALRF 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 374 gKDEVQIDIQDKTDTLT--ITVDDNGDGVPDEELEAIFRPFYRVSTARdrhsGGTGLGLTITESAIRQHSGTIVASRSPL 451
Cdd:PRK11466 577 -TDEGSIVLRSRTDGEQwlVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELSATSTPE 651
|
250
....*....|.
gi 491621032 452 GGLRVSITLPL 462
Cdd:PRK11466 652 VGSCFCLRLPL 662
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
252-462 |
2.85e-12 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 67.80 E-value: 2.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 252 LLSDISHELRSPLTRLRMASALATRKQGDsPELVR----IDTEAQRLEQMISELLELSRMQvnshmTRETQPIESLWEEI 327
Cdd:PRK11073 133 LVRGLAHEIKNPLGGLRGAAQLLSKALPD-PALTEytkvIIEQADRLRNLVDRLLGPQRPG-----THVTESIHKVAERV 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 328 IKDAQFEAEQMGKTLR-YS-EIPErhISGNPKLLMSAVENIIRNAIYYGKDE-----------VQIDIQDKTDTLT--IT 392
Cdd:PRK11073 207 VQLVSLELPDNVRLIRdYDpSLPE--LAHDPDQIEQVLLNIVRNALQALGPEggtitlrtrtaFQLTLHGERYRLAarID 284
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 393 VDDNGDGVPDEELEAIFRPFyrVSTardrHSGGTGLGLTITESAIRQHSGTIVASRSPlGGLRVSITLPL 462
Cdd:PRK11073 285 IEDNGPGIPPHLQDTLFYPM--VSG----REGGTGLGLSIARNLIDQHSGKIEFTSWP-GHTEFSVYLPI 347
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
355-454 |
3.96e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 62.48 E-value: 3.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 355 NPKLLMSAVENIIRNAIYYGKD--EVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYrvSTARDrHSG--GTGLGL 430
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEggLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFY--SLPRP-HSGqkSTGLGL 77
|
90 100
....*....|....*....|....
gi 491621032 431 TITESAIRQHSGTIVASRSPLGGL 454
Cdd:cd16945 78 AFVQEVAQLHGGRITLRNRPDGVL 101
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
249-306 |
5.52e-12 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 60.69 E-value: 5.52e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491621032 249 QQRLLSDISHELRSPLTRLRMASALATRKQGDSPE----LVRIDTEAQRLEQMISELLELSR 306
Cdd:cd00082 4 KGEFLANVSHELRTPLTAIRGALELLEEELLDDEEqreyLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
346-450 |
5.82e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 62.53 E-value: 5.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 346 EIPERHI--SGNPKLLMSAVENIIRNAIYYGKDE--VQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDR 421
Cdd:cd16947 6 NIPDRPIyaNANTEALQRILKNLISNAIKYGSDGkfLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNS 85
|
90 100
....*....|....*....|....*....
gi 491621032 422 HSGGTGLGLTITESAIRQHSGTIVASRSP 450
Cdd:cd16947 86 AKQGNGLGLTITKRLAESMGGSIYVNSKP 114
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
237-462 |
6.95e-12 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 67.78 E-value: 6.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 237 QMVEAVNQMISGqqrllsdISHELRSPLTRLRMASALATRKQGDSPELVR----IDTEAQRLEQMISELLELSRMQvnsh 312
Cdd:PRK13837 445 RRLEAVGTLASG-------IAHNFNNILGAILGYAEMALNKLARHSRAARyideIISAGARARLIIDQILAFGRKG---- 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 313 mTRETQPIE--------------SLWEEIIKDAQFEAEQMgktlryseiperHISGNPKLLMSAVENIIRNAIYYGKDEV 378
Cdd:PRK13837 514 -ERNTKPFDlselvteiapllrvSLPPGVELDFDQDQEPA------------VVEGNPAELQQVLMNLCSNAAQAMDGAG 580
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 379 QIDIQ------DKTDTLT-----------ITVDDNGDGVPDEELEAIFRPFYrvsTARdrhSGGTGLGLTITESAIRQHS 441
Cdd:PRK13837 581 RVDISlsraklRAPKVLShgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFF---TTR---AGGTGLGLATVHGIVSAHA 654
|
250 260
....*....|....*....|..
gi 491621032 442 GTI-VASRsPLGGLRVSITLPL 462
Cdd:PRK13837 655 GYIdVQST-VGRGTRFDVYLPP 675
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-461 |
7.07e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 61.78 E-value: 7.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 362 AVENIIRNA------IYYGKDEVQIDIQDKTDT-LTITVDDNGDGVPDEELEAIFRPFyrVSTArdrhSGGTGLGLTITE 434
Cdd:cd16944 8 VLTNILKNAaeaiegRPSDVGEVRIRVEADQDGrIVLIVCDNGKGFPREMRHRATEPY--VTTR----PKGTGLGLAIVK 81
|
90 100
....*....|....*....|....*..
gi 491621032 435 SAIRQHSGTIVASRSPLGGLRVSITLP 461
Cdd:cd16944 82 KIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-461 |
7.67e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 61.65 E-value: 7.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 359 LMSAVENIIRNAIYYGKDEV-QIDIQDKTD------------TLTITVDDNGDGVPDEELEAIFRPFyrVSTardrHSGG 425
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSGgEIILRTRTQrqvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPM--VSG----RENG 74
|
90 100 110
....*....|....*....|....*....|....*.
gi 491621032 426 TGLGLTITESAIRQHSGTIVASRSPlGGLRVSITLP 461
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQP-GHTVFSVSLP 109
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
249-308 |
2.32e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 59.15 E-value: 2.32e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491621032 249 QQRLLSDISHELRSPLTRLRMASALATRKQGDSPE---LVRIDTEAQRLEQMISELLELSRMQ 308
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQreyLETILRSAERLLRLINDLLDLSRIE 64
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
249-308 |
2.88e-11 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 58.73 E-value: 2.88e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491621032 249 QQRLLSDISHELRSPLTRLRMASALATRKQGDSPE---LVRIDTEAQRLEQMISELLELSRMQ 308
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQreyLETILREAERLLRLINDLLDLSRIE 64
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
365-461 |
3.28e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 59.72 E-value: 3.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 365 NIIRNAI----YYGKDEVQIDIQDKTDT---LTITVDDNGDGVPDEELEAIFRPFYrvSTARDrhsgGTGLGLTITESAI 437
Cdd:cd16920 7 NLVRNGIeamsEGGCERRELTIRTSPADdraVTISVKDTGPGIAEEVAGQLFDPFY--TTKSE----GLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 491621032 438 RQHSGTIVASRSPLGGLRVSITLP 461
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
234-462 |
3.75e-11 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 65.38 E-value: 3.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 234 SFNQMVEAVNQMISGQQRLLSDISHELRSPL-------------------TRLRMA----SALATRKQGDSPELVRIDTE 290
Cdd:PRK10841 432 SLQEMAQAAEQASQSKSMFLATVSHELRTPLygiignldllqtkelpkgvDRLVTAmnnsSSLLLKIISDILDFSKIESE 511
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 291 aqrleQMISELLELSRMQVNSHMTRETQPIeslweeIIKdaqfeaeqmgKTLR-Y----SEIPERhISGNPKLLMSAVEN 365
Cdd:PRK10841 512 -----QLKIEPREFSPREVINHITANYLPL------VVK----------KRLGlYcfiePDVPVA-LNGDPMRLQQVISN 569
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 366 IIRNAIYYgKDE--VQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITESAIRQHSGT 443
Cdd:PRK10841 570 LLSNAIKF-TDTgcIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGD 648
|
250
....*....|....*....
gi 491621032 444 IVASRSPLGGLRVSITLPL 462
Cdd:PRK10841 649 ISVDSEPGMGSQFTIRIPL 667
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-460 |
1.28e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 58.24 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 363 VENIIRNAI--YYGKDEVQIDI--QDKTDTLTITVDDNGDGVPDEELEAIFRPFYrvsTARDRhSGGTGLGLTITESAIR 438
Cdd:cd16976 5 LMNLLQNALdaMGKVENPRIRIaaRRLGGRLVLVVRDNGPGIAEEHLSRVFDPFF---TTKPV-GKGTGLGLSISYGIVE 80
|
90 100
....*....|....*....|..
gi 491621032 439 QHSGTIVASRSPLGGLRVSITL 460
Cdd:cd16976 81 EHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-461 |
2.25e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 57.30 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 359 LMSAVENIIRNAI------YYGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYrvSTardRHSGGTGLGLTI 432
Cdd:cd16915 1 LITIVGNLIDNALdalaatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV--ST---KGQGERGIGLAL 75
|
90 100
....*....|....*....|....*....
gi 491621032 433 TESAIRQHSGTIVASRSPLGGLRVSITLP 461
Cdd:cd16915 76 VRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
240-462 |
2.45e-10 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 63.21 E-value: 2.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 240 EAVNQMISGQQrLLSDISHELRSPLTR----LRMASALATRKQGDSPELVRIDTEAQRLEQMISELLELSRMQVNSHmtr 315
Cdd:PRK09959 704 KAINATVAKSQ-FLATMSHEIRTPISSimgfLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNY--- 779
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 316 ETQPiesLWEEIIKDAQ-----FEAEQMGKTLRYS---EIPERH-ISGNPKLLMSAVENIIRNAIYYGKDEV------QI 380
Cdd:PRK09959 780 QLQP---QWVDIPTLVQntchsFGAIAASKSIALScssTFPDHYlVKIDPQAFKQVLSNLLSNALKFTTEGAvkittsLG 856
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 381 DIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRhsGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITL 460
Cdd:PRK09959 857 HIDDNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQ--TGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITI 934
|
..
gi 491621032 461 PL 462
Cdd:PRK09959 935 PV 936
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-461 |
3.91e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 57.20 E-value: 3.91e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 359 LMSAVENIIRNAIYYGKDE---VQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITES 435
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtgrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 491621032 436 AIRQHSGTIVAS-RSPLG---GLRVSITLP 461
Cdd:cd16953 81 IIEAHGGISVAEnHNQPGqviGARFTVQLP 110
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
236-447 |
8.10e-10 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 60.86 E-value: 8.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 236 NQMVEAVNQMISGQQrlLSDISHELRSPLTRLRM---ASALATRKQGD---SPELVRIDTEAQRLEQMISELLELSRMQV 309
Cdd:COG4192 422 DELIQAAKMAVVGQT--MTSLAHELNQPLNAMSMylfSAKKALEQENYaqlPTSLDKIEGLIERMDKIIKSLRQFSRKSD 499
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 310 NS-HMTRETQPIESLWEEIIKDAQFEAEQMgktlrysEIPERH-ISGNPKLLMSAVENIIRNAI--YYGKDEVQIDIQDK 385
Cdd:COG4192 500 TPlQPVDLRQVIEQAWELVESRAKPQQITL-------HIPDDLmVQGDQVLLEQVLVNLLVNALdaVATQPQISVDLLSN 572
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491621032 386 TDTLTITVDDNGDGVPDeeLEAIFRPFYrvSTArdrhSGGTGLGLTITESAIRQHSGTI-VAS 447
Cdd:COG4192 573 AENLRVAISDNGNGWPL--VDKLFTPFT--TTK----EVGLGLGLSICRSIMQQFGGDLyLAS 627
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
357-461 |
2.84e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 54.60 E-value: 2.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 357 KLLMSAVENIIRNAIYYGK--DEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARdRHSGGTGLGLTITE 434
Cdd:cd16948 4 KWLSFIIGQIVSNALKYSKqgGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGR-NFQESTGMGLYLVK 82
|
90 100
....*....|....*....|....*..
gi 491621032 435 SAIRQHSGTIVASRSPLGGLRVSITLP 461
Cdd:cd16948 83 KLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
254-463 |
6.16e-09 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 58.41 E-value: 6.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 254 SDISHELRSPL------TRLRMASALATRKQG-----------------DSPEL-------VRIDTEAQRLEQMISELLE 303
Cdd:PRK11091 288 STISHELRTPLngivglSRILLDTELTAEQRKylktihvsaitlgnifnDIIDMdkmerrkLQLDNQPIDFTDFLADLEN 367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 304 LSRMQVnshmtretQPieslweeiiKDAQFEAEQMGktlrysEIPeRHISGNPKLLMSAVENIIRNAIYYGKD-EVQIDI 382
Cdd:PRK11091 368 LSGLQA--------EQ---------KGLRFDLEPLL------PLP-HKVITDGTRLRQILWNLISNAVKFTQQgGVTVRV 423
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 383 Q-DKTDTLTITVDDNGDGVPDEELEAIFRPFYRVSTARD-RHSGGTGLGLTITESAIRQHSGTIVASRSPLGGLR--VSI 458
Cdd:PRK11091 424 RyEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGgKPATGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCftLTI 503
|
....*
gi 491621032 459 TLPLV 463
Cdd:PRK11091 504 HAPAV 508
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
246-462 |
1.62e-08 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 57.25 E-value: 1.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 246 ISGQQRLLSDISHELRSPLTRLrMASALATRKQGD----SPELVRIDTEAQRLEQMISEL-----LELSRMQVNShmtrE 316
Cdd:PRK10618 447 QQARKAFLQNIGDELKQPLQSL-AQLAAQLRQTSDeeqqQPELDQLAEQSDVLVRLVDNIqllnmLETQDWKPEQ----E 521
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 317 TQPIESLWEEIIKDAQFEAEQMGKTL--RYSEIPERHISGNPKLLMSAVENIIRNAIY---YGKDEVQIDI-QDKTDTLT 390
Cdd:PRK10618 522 LFSLQDLIDEVLPEVLPAIKRKGLQLliHNHLKAEQLRIGDRDALRKILLLLLNYAITttaYGKITLEVDQdESSPDRLT 601
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491621032 391 ITVDDNGDGVPDEELEAIFRPFYRvSTARDRHSGGTGLGLTITESAIRQHSGTI-VASRSPLgGLRVSITLPL 462
Cdd:PRK10618 602 IRILDTGAGVSIKELDNLHFPFLN-QTQGDRYGKASGLTFFLCNQLCRKLGGHLtIKSREGL-GTRYSIHLKM 672
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
253-444 |
3.32e-07 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 52.93 E-value: 3.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 253 LSDISHELRSPL------TRLRMASALaTRKQGDSpeLVRIDTEAQRLEQMISELLELSRMQVNShMTRETQPI---ESL 323
Cdd:PRK11107 297 LANMSHELRTPLngvigfTRQTLKTPL-TPTQRDY--LQTIERSANNLLAIINDILDFSKLEAGK-LVLENIPFslrETL 372
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 324 WEEIIKDAQFEAEqmgKTLRYS-----EIPErHISGNPKLLMSAVENIIRNAIYYG-KDEVQIDIQ------DKTdTLTI 391
Cdd:PRK11107 373 DEVVTLLAHSAHE---KGLELTlnidpDVPD-NVIGDPLRLQQIITNLVGNAIKFTeSGNIDILVElralsnTKV-QLEV 447
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 491621032 392 TVDDNGDGVPDEELEAIFRPFYRVSTARDRHSGGTGLGLTITESAIRQHSGTI 444
Cdd:PRK11107 448 QIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDI 500
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
264-462 |
4.87e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 50.77 E-value: 4.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 264 LTRLRMASALATRKQGDSPELVRidTEAQRLEQMISELLELSRmQVNSHMTRETQPIESLWEEIIKDAQFEAEQMGKTLR 343
Cdd:COG4585 69 LSAIKLQLEAARRLLDADPEAAR--EELEEIRELAREALAELR-RLVRGLRPPALDDLGLAAALEELAERLLRAAGIRVE 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 344 YseiperHISGNPKLLMSAVEN----IIR----NAIYYGK-DEVQIDIQDKTDTLTITVDDNGDGVPDEELeaifrpfyr 414
Cdd:COG4585 146 L------DVDGDPDRLPPEVELalyrIVQealtNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPEAA--------- 210
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 491621032 415 vstardrhsGGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLPL 462
Cdd:COG4585 211 ---------PGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
362-461 |
8.46e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 46.78 E-value: 8.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 362 AVENIIRNAiyyGKDEVQIDIQDKTDTLTITVDDNGDGVPDEeleaifrpfyrvstardRHSGGTGLGLTITESAIRQHS 441
Cdd:cd16917 8 ALTNALKHA---GASRVRVTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERAELLG 67
|
90 100
....*....|....*....|
gi 491621032 442 GTIVASRSPLGGLRVSITLP 461
Cdd:cd16917 68 GTLTIGSRPGGGTRVTARLP 87
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
387-461 |
5.40e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 45.45 E-value: 5.40e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491621032 387 DTLTITVDDNGDGVPDEELEAIFRPFYrvsTARDRHSgGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLP 461
Cdd:cd16919 46 NYVCLEVSDTGSGMPAEVLRRAFEPFF---TTKEVGK-GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
197-247 |
6.56e-05 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 40.31 E-value: 6.56e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 491621032 197 SQPARRLEAAAQRVAKGEFVIDPNlEKGTAEFRQAGSSFNQMVEAVNQMIS 247
Cdd:smart00304 4 LRPLRRLAEAAQRIADGDLTVRLP-VDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
197-241 |
6.62e-05 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 40.12 E-value: 6.62e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 491621032 197 SQPARRLEAAAQRVAKGEFviDPNLE-KGTAEFRQAGSSFNQMVEA 241
Cdd:cd06225 1 TRPLRRLTEAARRIAEGDL--DVRVPvRSKDEIGELARAFNQMAER 44
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
369-462 |
1.01e-04 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 44.51 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 369 NAIYYG-----KDEVQIDIQDKTDTLTITVDDNGDGVPDEeleaiFRPfyrvstardrhSGGTGLGLTITESAIRQHSGT 443
Cdd:COG3920 410 NALKHAflsgeGGRIRVSWRREDGRLRLTVSDNGVGLPED-----VDP-----------PARKGLGLRLIRALVRQLGGT 473
|
90
....*....|....*....
gi 491621032 444 IVASRSPlgGLRVSITLPL 462
Cdd:COG3920 474 LELDRPE--GTRVRITFPL 490
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
352-464 |
1.81e-04 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 44.05 E-value: 1.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 352 ISGNpkLLMSAVENIIRNAiyYGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRpfYRVSTaRDRHSGGTGLGLT 431
Cdd:PRK15053 436 IVGN--LLDNAFEASLRSD--EGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFE--QGVST-RADEPGEHGIGLY 508
|
90 100 110
....*....|....*....|....*....|...
gi 491621032 432 ITESAIRQHSGTIVASRSPLGGLRVSITLPLVK 464
Cdd:PRK15053 509 LIASYVTRCGGVITLEDNDPCGTLFSIFIPKVK 541
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-408 |
3.34e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 40.10 E-value: 3.34e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 491621032 356 PKLLMSAVENIIRNAIYYGKDEVQIDIQDKTDT--LTITVDDNGDGVPDEELEAI 408
Cdd:cd16957 3 PFALQVLVENAIRHAFPKRKENNEVRVVVKKDQhkVHVSVSDNGQGIPEERLDLL 57
|
|
| HAMP |
pfam00672 |
HAMP domain; |
197-244 |
3.34e-04 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 38.37 E-value: 3.34e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 491621032 197 SQPARRLEAAAQRVAKGEFviDPNLE-KGTAEFRQAGSSFNQMVEAVNQ 244
Cdd:pfam00672 7 LRPLRRLAEAARRIASGDL--DVRLPvSGRDEIGELARAFNQMAERLRE 53
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|
| HATPase_SpoIIAB-like |
cd16942 |
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ... |
361-435 |
3.47e-03 |
|
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.
Pssm-ID: 340418 [Multi-domain] Cd Length: 135 Bit Score: 37.90 E-value: 3.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 361 SAVENIIRNAIY--YGKDE---VQIDIQDKTDTLTITVDDNGDGVPDeeLEAIFRPFYRVSTARDRhsggTGLGLTITES 435
Cdd:cd16942 41 TVVSEAVTNAIIhgYNNDPngiVSISVIIEDGVVHLTVRDEGVGIPD--IEEARQPLFTTKPELER----SGMGFTIMEN 114
|
|
| HATPase_MutL-MLH-PMS-like |
cd16926 |
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ... |
361-413 |
5.86e-03 |
|
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.
Pssm-ID: 340403 [Multi-domain] Cd Length: 188 Bit Score: 37.80 E-value: 5.86e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 491621032 361 SAVENIIRNAIYYGKDEVQIDIQDKTDTLtITVDDNGDGVPDEELEAIFRPFY 413
Cdd:cd16926 16 SVVKELVENSIDAGATRIDVEIEEGGLKL-IRVTDNGSGISREDLELAFERHA 67
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
345-461 |
8.03e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 38.74 E-value: 8.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491621032 345 SEIPErhiSGNPKL---LMSAVENIIRNAI----YYGKDEVQIDIQDKTDTLTITVDDNGDGVPDEELEAIFRPFYrvST 417
Cdd:PRK11086 420 SQLPD---SGDEDQvheLITILGNLIENALeavgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY--ST 494
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 491621032 418 ARDrhsgGTGLGLTITESAIRQHSGTIVASRSPLGGLRVSITLP 461
Cdd:PRK11086 495 KGS----NRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIP 534
|
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| |
