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Conserved domains on  [gi|491624892|ref|WP_005482432|]
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MULTISPECIES: phosphoglycerate kinase [Vibrio]

Protein Classification

phosphoglycerate kinase( domain architecture ID 10011204)

phosphoglycerate kinase catalyzes the conversion of ATP and 3-phospho-D-glycerate to ADP and 3-phospho-D-glyceroyl phosphate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-383 0e+00

phosphoglycerate kinase; Provisional


:

Pssm-ID: 234613  Cd Length: 389  Bit Score: 636.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   3 VIKMTDLDLAGKRVFIRADLNVPVKDGKVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPTeGEYaEEFSLQPVVNYLN 82
Cdd:PRK00073   1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GED-PEFSLAPVAKRLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  83 DALDCEVKLAKDYLDG------LELNAGELVVLENVRFNKGEKKNEEELSKKYAALCDVFVMDAFGTAHRAQASTHGVGM 156
Cdd:PRK00073  79 ELLGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIAK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 157 HAPVACAGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLYEA 236
Cdd:PRK00073 159 FLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVEE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 237 DLVDTAKKLMDE-----CAIPVATDVACAKAFdENAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWNGPVG 311
Cdd:PRK00073 239 DLIDTAKELLEKakekgVKIPLPVDVVVAKEF-SDAEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPMG 317
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491624892 312 VFEFKNFEAGTKGISEAIAASEGFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVEMLEA 383
Cdd:PRK00073 318 VFEFENFAKGTKAVAKAIAESTAFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
 
Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-383 0e+00

phosphoglycerate kinase; Provisional


Pssm-ID: 234613  Cd Length: 389  Bit Score: 636.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   3 VIKMTDLDLAGKRVFIRADLNVPVKDGKVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPTeGEYaEEFSLQPVVNYLN 82
Cdd:PRK00073   1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GED-PEFSLAPVAKRLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  83 DALDCEVKLAKDYLDG------LELNAGELVVLENVRFNKGEKKNEEELSKKYAALCDVFVMDAFGTAHRAQASTHGVGM 156
Cdd:PRK00073  79 ELLGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIAK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 157 HAPVACAGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLYEA 236
Cdd:PRK00073 159 FLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVEE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 237 DLVDTAKKLMDE-----CAIPVATDVACAKAFdENAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWNGPVG 311
Cdd:PRK00073 239 DLIDTAKELLEKakekgVKIPLPVDVVVAKEF-SDAEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPMG 317
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491624892 312 VFEFKNFEAGTKGISEAIAASEGFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVEMLEA 383
Cdd:PRK00073 318 VFEFENFAKGTKAVAKAIAESTAFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
Pgk COG0126
3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase ...
6-384 0e+00

3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439896  Cd Length: 389  Bit Score: 541.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   6 MTDLDLAGKRVFIRADLNVPVKDGKVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPtEGEYAEEFSLQPVVNYLNDAL 85
Cdd:COG0126    2 LDDLDLKGKRVLVRVDFNVPLDDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRP-KGKVDPKYSLKPVAERLSELL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  86 DCEVKLAKDyLDG-------LELNAGELVVLENVRFNKGEKKNEEELSKKYAALCDVFVMDAFGTAHRAQASTHGVGMHA 158
Cdd:COG0126   81 GKPVKFVDD-CIGeeaeaavAALKPGEVLLLENLRFHPEEEKNDPEFAKKLASLGDVYVNDAFGTAHRAHASTVGIAKLL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 159 PvACAGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLYEADL 238
Cdd:COG0126  160 P-SAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMANTFLKAQGYDVGKSLVEEDK 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 239 VDTAKKLMDE-----CAIPVATDVACAKAFDENAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWNGPVGVF 313
Cdd:COG0126  239 IDTAKEILEKakekgVKIVLPVDVVVADEFSADAERKVVPVDEIPDDWMGLDIGPKTIELFAEVIKDAKTVVWNGPMGVF 318
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491624892 314 EFKNFEAGTKGISEAIAASEGFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVEMLEAR 384
Cdd:COG0126  319 EMEPFAKGTRAVAKAIAESGAFSVVGGGDTAAAVNKLGLADKFSHVSTGGGASLEFLEGKELPGVEALEDK 389
PGK pfam00162
Phosphoglycerate kinase;
13-373 0e+00

Phosphoglycerate kinase;


Pssm-ID: 425495  Cd Length: 370  Bit Score: 533.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   13 GKRVFIRADLNVPVKD-GKVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPtEGEYaEEFSLQPVVNYLNDALDCEVKL 91
Cdd:pfam00162   1 GKRVLVRVDFNVPLDDdGKITDDTRIRAALPTIKYLLEKGAKVILMSHLGRP-KGKD-DKFSLKPVAERLSELLGKPVKF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   92 AKDYLDG------LELNAGELVVLENVRFNKGEKKNEEELSKKYAALCDVFVMDAFGTAHRAQASTHGVGMHAPvACAGP 165
Cdd:pfam00162  79 ADDCIGPeaeaaiAALKPGEVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTVGVAKFLP-SAAGF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  166 LLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLYEADLVDTAKKL 245
Cdd:pfam00162 158 LMEKELEALSKALENPERPFVAILGGAKVSDKIGVIENLLDKVDKLIIGGGMANTFLKAQGYEIGKSLVEEDKIELAKEL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  246 MDE-----CAIPVATDVACAKAFDenAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWNGPVGVFEFKNFEA 320
Cdd:pfam00162 238 LEKakakgVKIVLPVDVVVADEFS--AEGKVVDVDEIPDDWMGLDIGPETIELFAEVIKKAKTIVWNGPMGVFEFENFAK 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 491624892  321 GTKGISEAIAASE--GFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGK 373
Cdd:pfam00162 316 GTKAVAKAIAEATagAFSIVGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGK 370
Phosphoglycerate_kinase cd00318
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the ...
6-382 2.61e-171

Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level phosphorylation events in the glycolytic pathway. Substrate-level phosphorylation is defined as production of ATP by a process, which is catalyzed by water-soluble enzymes in the cytosol; not involving membranes and ion gradients.


Pssm-ID: 238195  Cd Length: 397  Bit Score: 483.68  E-value: 2.61e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   6 MTDLDLAGKRVFIRADLNVPVKDGKVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPTeGEYAEEFSLQPVVNYLNDAL 85
Cdd:cd00318    1 IDDLDLKGKRVLVRVDFNVPVDDGKITDDTRIRAALPTIKYLLEQGAKVVLLSHLGRPK-GEPNEKYSLAPVAKALSELL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  86 DCEVKLAKDYLDGL------ELNAGELVVLENVRFNKGEKKN-------EEELSKKYAALCDVFVMDAFGTAHRAQASTH 152
Cdd:cd00318   80 GQPVTFANDCVGPEaeeaveALKPGDVLLLENVRFYPEEEGKrdddkeaDEEFAKKLASLGDVYVNDAFGTAHRAHASMV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 153 GVGmHAPVACAGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKS 232
Cdd:cd00318  160 GIA-LLLPSAAGFLMEKELKYLAKALENPERPFVAILGGAKVSDKIQVIENLLDKVDYLIIGGGMAFTFLKAQGMDIGKS 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 233 LYEADLVDTAKKLMDE-----CAIPVATDVACAKAFDENAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWN 307
Cdd:cd00318  239 LFEEDGIELAKSLLEKakakgVKIVLPVDVVVADKFKADANTKVVTDDGIPDGWMGLDIGPKTIELFAEVIRKAKTIVWN 318
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491624892 308 GPVGVFEFKNFEAGTKGISEAIAASE---GFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVEMLE 382
Cdd:cd00318  319 GPMGVFEFPAFAKGTKAIADAIAAATkagAFSIIGGGDTAAAAEKFGLADKISHVSTGGGASLELLEGKELPGVAALE 396
 
Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-383 0e+00

phosphoglycerate kinase; Provisional


Pssm-ID: 234613  Cd Length: 389  Bit Score: 636.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   3 VIKMTDLDLAGKRVFIRADLNVPVKDGKVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPTeGEYaEEFSLQPVVNYLN 82
Cdd:PRK00073   1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GED-PEFSLAPVAKRLS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  83 DALDCEVKLAKDYLDG------LELNAGELVVLENVRFNKGEKKNEEELSKKYAALCDVFVMDAFGTAHRAQASTHGVGM 156
Cdd:PRK00073  79 ELLGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIAK 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 157 HAPVACAGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLYEA 236
Cdd:PRK00073 159 FLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVEE 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 237 DLVDTAKKLMDE-----CAIPVATDVACAKAFdENAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWNGPVG 311
Cdd:PRK00073 239 DLIDTAKELLEKakekgVKIPLPVDVVVAKEF-SDAEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPMG 317
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491624892 312 VFEFKNFEAGTKGISEAIAASEGFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVEMLEA 383
Cdd:PRK00073 318 VFEFENFAKGTKAVAKAIAESTAFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
Pgk COG0126
3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase ...
6-384 0e+00

3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439896  Cd Length: 389  Bit Score: 541.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   6 MTDLDLAGKRVFIRADLNVPVKDGKVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPtEGEYAEEFSLQPVVNYLNDAL 85
Cdd:COG0126    2 LDDLDLKGKRVLVRVDFNVPLDDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRP-KGKVDPKYSLKPVAERLSELL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  86 DCEVKLAKDyLDG-------LELNAGELVVLENVRFNKGEKKNEEELSKKYAALCDVFVMDAFGTAHRAQASTHGVGMHA 158
Cdd:COG0126   81 GKPVKFVDD-CIGeeaeaavAALKPGEVLLLENLRFHPEEEKNDPEFAKKLASLGDVYVNDAFGTAHRAHASTVGIAKLL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 159 PvACAGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLYEADL 238
Cdd:COG0126  160 P-SAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMANTFLKAQGYDVGKSLVEEDK 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 239 VDTAKKLMDE-----CAIPVATDVACAKAFDENAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWNGPVGVF 313
Cdd:COG0126  239 IDTAKEILEKakekgVKIVLPVDVVVADEFSADAERKVVPVDEIPDDWMGLDIGPKTIELFAEVIKDAKTVVWNGPMGVF 318
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491624892 314 EFKNFEAGTKGISEAIAASEGFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVEMLEAR 384
Cdd:COG0126  319 EMEPFAKGTRAVAKAIAESGAFSVVGGGDTAAAVNKLGLADKFSHVSTGGGASLEFLEGKELPGVEALEDK 389
PGK pfam00162
Phosphoglycerate kinase;
13-373 0e+00

Phosphoglycerate kinase;


Pssm-ID: 425495  Cd Length: 370  Bit Score: 533.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   13 GKRVFIRADLNVPVKD-GKVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPtEGEYaEEFSLQPVVNYLNDALDCEVKL 91
Cdd:pfam00162   1 GKRVLVRVDFNVPLDDdGKITDDTRIRAALPTIKYLLEKGAKVILMSHLGRP-KGKD-DKFSLKPVAERLSELLGKPVKF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   92 AKDYLDG------LELNAGELVVLENVRFNKGEKKNEEELSKKYAALCDVFVMDAFGTAHRAQASTHGVGMHAPvACAGP 165
Cdd:pfam00162  79 ADDCIGPeaeaaiAALKPGEVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTVGVAKFLP-SAAGF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  166 LLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLYEADLVDTAKKL 245
Cdd:pfam00162 158 LMEKELEALSKALENPERPFVAILGGAKVSDKIGVIENLLDKVDKLIIGGGMANTFLKAQGYEIGKSLVEEDKIELAKEL 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  246 MDE-----CAIPVATDVACAKAFDenAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWNGPVGVFEFKNFEA 320
Cdd:pfam00162 238 LEKakakgVKIVLPVDVVVADEFS--AEGKVVDVDEIPDDWMGLDIGPETIELFAEVIKKAKTIVWNGPMGVFEFENFAK 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 491624892  321 GTKGISEAIAASE--GFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGK 373
Cdd:pfam00162 316 GTKAVAKAIAEATagAFSIVGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGK 370
Phosphoglycerate_kinase cd00318
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the ...
6-382 2.61e-171

Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level phosphorylation events in the glycolytic pathway. Substrate-level phosphorylation is defined as production of ATP by a process, which is catalyzed by water-soluble enzymes in the cytosol; not involving membranes and ion gradients.


Pssm-ID: 238195  Cd Length: 397  Bit Score: 483.68  E-value: 2.61e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   6 MTDLDLAGKRVFIRADLNVPVKDGKVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPTeGEYAEEFSLQPVVNYLNDAL 85
Cdd:cd00318    1 IDDLDLKGKRVLVRVDFNVPVDDGKITDDTRIRAALPTIKYLLEQGAKVVLLSHLGRPK-GEPNEKYSLAPVAKALSELL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  86 DCEVKLAKDYLDGL------ELNAGELVVLENVRFNKGEKKN-------EEELSKKYAALCDVFVMDAFGTAHRAQASTH 152
Cdd:cd00318   80 GQPVTFANDCVGPEaeeaveALKPGDVLLLENVRFYPEEEGKrdddkeaDEEFAKKLASLGDVYVNDAFGTAHRAHASMV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 153 GVGmHAPVACAGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKS 232
Cdd:cd00318  160 GIA-LLLPSAAGFLMEKELKYLAKALENPERPFVAILGGAKVSDKIQVIENLLDKVDYLIIGGGMAFTFLKAQGMDIGKS 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 233 LYEADLVDTAKKLMDE-----CAIPVATDVACAKAFDENAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWN 307
Cdd:cd00318  239 LFEEDGIELAKSLLEKakakgVKIVLPVDVVVADKFKADANTKVVTDDGIPDGWMGLDIGPKTIELFAEVIRKAKTIVWN 318
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491624892 308 GPVGVFEFKNFEAGTKGISEAIAASE---GFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVEMLE 382
Cdd:cd00318  319 GPMGVFEFPAFAKGTKAIADAIAAATkagAFSIIGGGDTAAAAEKFGLADKISHVSTGGGASLELLEGKELPGVAALE 396
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
8-381 6.99e-139

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 409.89  E-value: 6.99e-139
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   8 DLDLAGKRVFIRADLNVPVK-DGKVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPtEGEYAEEFSLQPVVNYLNDALD 86
Cdd:PRK13962   8 DIDVKGKRVIVRVDFNVPLDeNGNITDDTRIRAALPTIKYLLDHGAKVILVSHLGRP-KGEFDPKFSMAPVAKRLSELLG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  87 CEVKLAKDYLDG------LELNAGELVVLENVRFNKGEKKNEEELSKKYAALCDVFVMDAFGTAHRAQASTHGVGMHAPV 160
Cdd:PRK13962  87 KEVIFAKDVIGDdakkavAQLKEGDVLLLENVRFHKEETKNDPEFAKELASLADIYVNDAFGTAHRAHASTAGVAEYLPA 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 161 ACaGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLYEADLVD 240
Cdd:PRK13962 167 VA-GFLMEKEIEFLGKALANPQRPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMAYTFLKAKGYEVGKSLVEEDKLD 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 241 TAKKLMDECA-------IPVatDVACAKAFDENAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWNGPVGVF 313
Cdd:PRK13962 246 LAKELLAKAEekgvkllLPV--DSVVAKEFKNDAEHKVVPSDAIPEDWMGLDIGPETIELFAKKIADAKTIVWNGPMGVF 323
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491624892 314 EFKNFEAGTKGISEAIAASEGFSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVEML 381
Cdd:PRK13962 324 EFDNFAEGTRAVAEAVAESGAITIIGGGDSAAAVEKLGFADKMSHISTGGGASLEFLEGKVLPGIACL 391
PLN02282 PLN02282
phosphoglycerate kinase
2-382 2.23e-110

phosphoglycerate kinase


Pssm-ID: 165923  Cd Length: 401  Bit Score: 328.85  E-value: 2.23e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   2 SVIKMTDLDLAGKRVFIRADLNVPVKDG-KVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPTEgeYAEEFSLQPVVNY 80
Cdd:PLN02282   6 SVGTLKEADLKGKRVFVRVDLNVPLDDNsNITDDTRIRAAVPTIKYLMGHGARVILCSHLGRPKG--VTPKYSLKPLVPR 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  81 LNDALDCEVKLAKDYLD------GLELNAGELVVLENVRFNKGEKKNEEELSKKYAALCDVFVMDAFGTAHRAQASTHGV 154
Cdd:PLN02282  84 LSELLGVEVVMANDCIGeeveklVAELPEGGVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTEGV 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 155 GMHAPVACAGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSLY 234
Cdd:PLN02282 164 AKYLKPSVAGFLMQKELDYLVGAVANPKKPFAAIVGGSKVSTKIGVIESLLEKVDILLLGGGMIFTFYKAQGYSVGSSLV 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 235 EADLVDTAKKLMDEC-----AIPVATDVACAKAFDENAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWNGP 309
Cdd:PLN02282 244 EEDKLDLATSLIEKAkakgvSLLLPTDVVIADKFAPDANSKVVPASAIPDGWMGLDIGPDSIKTFSEALDTTKTIIWNGP 323
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491624892 310 VGVFEFKNFEAGTKGISEAIAASEGFSVA---GGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVEMLE 382
Cdd:PLN02282 324 MGVFEFEKFAAGTEAIAKKLAELSGKGVTtiiGGGDSVAAVEKVGLADKMSHISTGGGASLELLEGKPLPGVLALD 399
PLN03034 PLN03034
phosphoglycerate kinase; Provisional
2-382 1.57e-107

phosphoglycerate kinase; Provisional


Pssm-ID: 178602 [Multi-domain]  Cd Length: 481  Bit Score: 324.26  E-value: 1.57e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   2 SVIKMTDLDLAGKRVFIRADLNVPVKDG-KVTSDARIIASLPTIKHCLEAGAKVMVTSHLGRPTEgeYAEEFSLQPVVNY 80
Cdd:PLN03034  81 SVGDLTSADLKGKKVFVRADLNVPLDDNqNITDDTRIRAAIPTIKYLISNGAKVILSSHLGRPKG--VTPKFSLAPLVPR 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  81 LNDALDCEVKLAKDYLdGLE-------LNAGELVVLENVRFNKGEKKNEEELSKKYAALCDVFVMDAFGTAHRAQASTHG 153
Cdd:PLN03034 159 LSELLGIQVVKADDCI-GPEveklvasLPEGGVLLLENVRFYKEEEKNEPEFAKKLASLADLYVNDAFGTAHRAHASTEG 237
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 154 VGMHAPVACAGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANTFIAAAGHNVGKSL 233
Cdd:PLN03034 238 VTKFLKPSVAGFLLQKELDYLVGAVSNPKRPFAAIVGGSKVSSKIGVIESLLEKCDILLLGGGMIFTFYKAQGLSVGSSL 317
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 234 YEADLVDTAKKLMDEC-----AIPVATDVACAKAFDENAEAEIKHVSEVQDDDMIFDLGPESTAALAEILKNAKTILWNG 308
Cdd:PLN03034 318 VEEDKLELATSLLAKAkakgvSLLLPTDVVIADKFAPDANSKIVPASAIPDGWMGLDIGPDSVKTFNEALDTTQTVIWNG 397
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491624892 309 PVGVFEFKNFEAGTKGISEAIAASEGFSVA---GGGDTLAAIDKFGIKADVSYISTGGGAFLEFVEGKVLPAVEMLE 382
Cdd:PLN03034 398 PMGVFEFEKFAVGTEAVAKKLAELSGKGVTtiiGGGDSVAAVEKVGVADVMSHISTGGGASLELLEGKELPGVVALD 474
PTZ00005 PTZ00005
phosphoglycerate kinase; Provisional
4-381 5.17e-103

phosphoglycerate kinase; Provisional


Pssm-ID: 173310  Cd Length: 417  Bit Score: 310.46  E-value: 5.17e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892   4 IKMTDLDLAGKRVFIRADLNVPVKDGKVTSDARIIASLPTIKHCLEAGAK-VMVTSHLGRPtEGEYAEEFSLQPVVNYLN 82
Cdd:PTZ00005   8 IDDVDDQLKGKRVLIRVDFNVPIKEGVIKDATRIKATLPTIKYLLEQGAKsVVLMSHLGRP-DGRRVEKYSLKPVVPKLE 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892  83 DALDCEVKLAKDYLdGLELNA-------GELVVLENVRFNKGE------------KKNEEELSK---KYAALCDVFVMDA 140
Cdd:PTZ00005  87 ELLGKKVTFLNDCV-GPEVEEacanaknGSVILLENLRFHIEEegkgvdangnkvKADKEEVKKfrkSLTKLGDIYVNDA 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 141 FGTAHRAQASTHGVGMhaPVACAGPLLANELEALGKAMDKPARPMVAIVGGSKVSTKLTVLESLSKIADQLVVGGGIANT 220
Cdd:PTZ00005 166 FGTAHRAHSSMVGVDL--PVKVAGFLMKKELDYFSKALENPQRPFLAILGGAKVADKIQLIKNLLDKVDEMIIGGGMAFT 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 221 FIAA-AGHNVGKSLYEADLVDTAKKLMDECA-----IPVATDVACAKAFDENAEAEIKHVSE-VQDDDMIFDLGPESTAA 293
Cdd:PTZ00005 244 FKKVlDNMPIGKSLFDEEGAKIVKEIMEKAKeknvkIHLPVDFVCADKFDNNANTKVVTDKEgIPDGWMGLDAGPKSIEE 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491624892 294 LAEILKNAKTILWNGPVGVFEFKNFEAGTKGISEAI--AASEG-FSVAGGGDTLAAIDKFGIKADVSYISTGGGAFLEFV 370
Cdd:PTZ00005 324 FAEAILRAKTIVWNGPQGVFEMPNFAKGSIAMLDAVvkATEKGaITIVGGGDTASLVEKTGAANKVSHVSTGGGASLELL 403
                        410
                 ....*....|.
gi 491624892 371 EGKVLPAVEML 381
Cdd:PTZ00005 404 EGKELPGVVAL 414
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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