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Conserved domains on  [gi|491627611|ref|WP_005485150|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Vibrio]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-138 4.07e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 161.87  E-value: 4.07e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627611   1 MDKIDRQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISGYRAMISRGAVGIAMTVFVEVSLNNHQassID 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR---LD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491627611  81 EFETAIVDMDEVISCHVVSGAYDYLLEVVSKDLPGYESF-TRKLQRLENVKDIHTHLAI 138
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFlLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-138 4.07e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 161.87  E-value: 4.07e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627611   1 MDKIDRQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISGYRAMISRGAVGIAMTVFVEVSLNNHQassID 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR---LD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491627611  81 EFETAIVDMDEVISCHVVSGAYDYLLEVVSKDLPGYESF-TRKLQRLENVKDIHTHLAI 138
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFlLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-109 1.96e-39

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 128.79  E-value: 1.96e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627611     1 MDKIDRQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISGYRAMISRGAVGIAMTVFVEVSLNNhqASSID 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLEN--PDKLE 78

                           90       100
                   ....*....|....*....|....*....
gi 491627611    81 EFETAIVDMDEVISCHVVSGAYDYLLEVV 109
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVR 107
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-142 2.65e-35

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 119.87  E-value: 2.65e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627611   1 MDKIDRQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISGYRAMISRGAVGIAMTVFVEVSLNNHQASSID 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491627611  81 EFETAIVDMDEVISCHVVSGAYDYLLEVVSKDLPGYESFT-RKLQRLENVKDIHTHLAIRQVK 142
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLgETLLRLPGVNDTRTYVVMEEVK 154
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 67-140 8.00e-19

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 75.25  E-value: 8.00e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491627611   67 VEVSLNNHQAssIDEFETAIVDMDEVISCHVVSGAYDYLLEVVSKDLPGYESFT-RKLQRLENVKDIHTHLAIRQ 140
Cdd:pfam01037   1 VEVKLEPGHA--LEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLrEKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-52 2.27e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 45.75  E-value: 2.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 491627611   2 DKIDRQLLHLIQKDAtLTTAELADQVGLSASPCARRLKRLEQEGVISGYRA 52
Cdd:cd00090    6 DPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-138 4.07e-52

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 161.87  E-value: 4.07e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627611   1 MDKIDRQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISGYRAMISRGAVGIAMTVFVEVSLNNHQassID 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHR---LD 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491627611  81 EFETAIVDMDEVISCHVVSGAYDYLLEVVSKDLPGYESF-TRKLQRLENVKDIHTHLAI 138
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFlLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-109 1.96e-39

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 128.79  E-value: 1.96e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627611     1 MDKIDRQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISGYRAMISRGAVGIAMTVFVEVSLNNhqASSID 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLEN--PDKLE 78

                           90       100
                   ....*....|....*....|....*....
gi 491627611    81 EFETAIVDMDEVISCHVVSGAYDYLLEVV 109
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVR 107
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-142 2.65e-35

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 119.87  E-value: 2.65e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627611   1 MDKIDRQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISGYRAMISRGAVGIAMTVFVEVSLNNHQASSID 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491627611  81 EFETAIVDMDEVISCHVVSGAYDYLLEVVSKDLPGYESFT-RKLQRLENVKDIHTHLAIRQVK 142
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLgETLLRLPGVNDTRTYVVMEEVK 154
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 67-140 8.00e-19

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 75.25  E-value: 8.00e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491627611   67 VEVSLNNHQAssIDEFETAIVDMDEVISCHVVSGAYDYLLEVVSKDLPGYESFT-RKLQRLENVKDIHTHLAIRQ 140
Cdd:pfam01037   1 VEVKLEPGHA--LEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLrEKLRSLPGVARTETSIVLST 73
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 4.53e-16

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 67.01  E-value: 4.53e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 491627611    2 DKIDRQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
3-47 4.12e-15

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 64.76  E-value: 4.12e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 491627611    3 KIDRQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVI 47
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-134 1.78e-10

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 55.49  E-value: 1.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627611   1 MDKIDRQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISGYRAMISRGAVGIAMTVFVEVSLNnhqasSID 80
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILK-----SAK 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 491627611  81 EFETAIV---DMDEVISCHVVSGAYDYLLEVVSKDLPGYES-FTRKLQRLENVKDIHT 134
Cdd:PRK11179  82 DYPSALAkleSLDEVVEAYYTTGHYSIFIKVMCRSIDALQHvLINKIQTIDEIQSTET 139
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 2-52 2.27e-07

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 45.75  E-value: 2.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 491627611   2 DKIDRQLLHLIQKDAtLTTAELADQVGLSASPCARRLKRLEQEGVISGYRA 52
Cdd:cd00090    6 DPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-47 9.07e-05

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.68  E-value: 9.07e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 491627611   6 RQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVI 47
Cdd:COG2345   16 RRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLV 57
Rfk COG1339
Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal ...
 8-64 1.36e-04

Archaeal CTP-dependent riboflavin kinase [Coenzyme transport and metabolism]; Archaeal CTP-dependent riboflavin kinase is part of the Pathway/BioSystem: Riboflavin/FAD biosynthesis


Pssm-ID: 440950 [Multi-domain]  Cd Length: 219  Bit Score: 40.21  E-value: 1.36e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491627611   8 LLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISgyRAMISRGaVGIAMT 64
Cdd:COG1339   13 LLGALKGPVKISSSELAKRLGISQQTASRRLQELEDAGLIE--RDLVGDG-QWVKIT 66
PriA COG1198
Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, ...
 6-85 1.28e-03

Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440811 [Multi-domain]  Cd Length: 728  Bit Score: 37.79  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627611   6 RQLL-HLIQKDATLTTAELADQVGLSASPcarrLKRLEQEGVISGYRAMISRGAVGIAMTVFVEVSLNNHQASSIDEFET 84
Cdd:COG1198  134 RRVLeALREHGGPLTLSELAKEAGVSRSV----LKALVKKGLLEIEEREVDRDPFAPDVPAEPPPTLNEEQQAAVEAIRA 209


                 .
gi 491627611  85 A 85
Cdd:COG1198  210 A 210
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
6-92 2.09e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 35.78  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491627611   6 RQLL-HLIQKDATLTtaELADQVGLSASPCARRLKRLEQEGVISGYRamiSRGAVGIAMTVFVEVSLNNHQASSIDEFET 84
Cdd:COG1777   20 RRILaLLSEEPAYVS--ELARELGVSRQAVYKHLRKLEEAGLVESYR---EGREDGRARKYYRLSAFRLEVTLTPDLFAR 94


                 ....*...
gi 491627611  85 AIVDMDEV 92
Cdd:COG1777   95 LARELEAY 102
PRK14165 PRK14165
winged helix-turn-helix domain-containing protein/riboflavin kinase; Provisional
 8-64 3.13e-03

winged helix-turn-helix domain-containing protein/riboflavin kinase; Provisional


Pssm-ID: 184548 [Multi-domain]  Cd Length: 217  Bit Score: 36.20  E-value: 3.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491627611   8 LLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISgyRAMISRGAVgIAMT 64
Cdd:PRK14165  12 LLGAVNNTVKISSSEFANHTGTSSKTAARILKQLEDEGYIT--RTIVPRGQL-ITIT 65
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 7-47 4.68e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 33.72  E-value: 4.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 491627611    7 QLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVI 47
Cdd:pfam12802   9 RVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLV 49
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
8-47 6.74e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 34.55  E-value: 6.74e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 491627611   8 LLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVI 47
Cdd:COG3355   33 YLILLENGEPLTVEELAEALDRSRSTVYRSLQKLLEAGLV 72
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 8-51 7.12e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 33.73  E-value: 7.12e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 491627611   8 LLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVISGYR 51
Cdd:COG2512   21 LELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKER 64
HTH_CRP cd00092
helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic ...
 6-48 8.46e-03

helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family.


Pssm-ID: 238044 [Multi-domain]  Cd Length: 67  Bit Score: 33.02  E-value: 8.46e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 491627611   6 RQLLHLIQKDATLTTAELADQVGLSASPCARRLKRLEQEGVIS 48
Cdd:cd00092   14 LRYGAGDLVQLPLTRQEIADYLGLTRETVSRTLKELEEEGLIS 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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