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Conserved domains on  [gi|491654596|ref|WP_005511316|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Corynebacterium]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-77 4.39e-17

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 70.58  E-value: 4.39e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491654596   4 ITAIVSIDVEADKIPEAAETIVEIDGVTEVYSVTGDWDLVVVVRATNHDDLAEIIPNLISKVDGVIRTQTQLAF 77
Cdd:COG1522   65 VTAFVEVKVPPHRLDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-77 4.39e-17

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 70.58  E-value: 4.39e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491654596   4 ITAIVSIDVEADKIPEAAETIVEIDGVTEVYSVTGDWDLVVVVRATNHDDLAEIIPNLISKVDGVIRTQTQLAF 77
Cdd:COG1522   65 VTAFVEVKVPPHRLDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 8-79 2.77e-15

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 64.08  E-value: 2.77e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491654596   8 VSIDVEADKIPEA-AETIVEIDGVTEVYSVTGDWDLVVVVRATNHDDLAEIIPNLISKVDGVIRTQTQLAFRT 79
Cdd:pfam01037  1 VEVKLEPGHALEEfAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-48 2.83e-08

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 47.13  E-value: 2.83e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 491654596     4 ITAIVSIDVE-ADKIPEAAETIVEIDGVTEVYSVTGDWDLVVVVRA 48
Cdd:smart00344  63 VTAFVGVTLEnPDKLEEFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
4-77 4.39e-17

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 70.58  E-value: 4.39e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491654596   4 ITAIVSIDVEADKIPEAAETIVEIDGVTEVYSVTGDWDLVVVVRATNHDDLAEIIPNLISKVDGVIRTQTQLAF 77
Cdd:COG1522   65 VTAFVEVKVPPHRLDEFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 8-79 2.77e-15

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 64.08  E-value: 2.77e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491654596   8 VSIDVEADKIPEA-AETIVEIDGVTEVYSVTGDWDLVVVVRATNHDDLAEIIPNLISKVDGVIRTQTQLAFRT 79
Cdd:pfam01037  1 VEVKLEPGHALEEfAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 4-48 2.83e-08

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 47.13  E-value: 2.83e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 491654596     4 ITAIVSIDVE-ADKIPEAAETIVEIDGVTEVYSVTGDWDLVVVVRA 48
Cdd:smart00344  63 VTAFVGVTLEnPDKLEEFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
NapD pfam03927
NapD protein; Uncharacterized protein involved in formation of periplasmic nitrate reductase.
 7-69 3.72e-03

NapD protein; Uncharacterized protein involved in formation of periplasmic nitrate reductase.


Pssm-ID: 427593  Cd Length: 71  Bit Score: 32.84  E-value: 3.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491654596   7 IVSIDVEA--DKIPEAAETIVEIDGVtEVYSVTGDWDLVVVVRATNHDDLAEIIpNLISKVDGVI 69
Cdd:pfam03927  1 ISSLVVQVrpERLAAVKEALAALPGV-EVHAEDEEGKLVVVIEAESQGEILDII-DAINALPGVL 63
NapD COG3062
Cytoplasmic chaperone NapD for the signal peptide of periplasmic nitrate reductase NapAB ...
 1-69 6.14e-03

Cytoplasmic chaperone NapD for the signal peptide of periplasmic nitrate reductase NapAB [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442296  Cd Length: 86  Bit Score: 32.90  E-value: 6.14e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491654596  1 MSLITAIVSIDVEA--DKIPEAAETIVEIDGVtEVYSVTGDWDLVVVVRATNHDDLAEIIpNLISKVDGVI 69
Cdd:COG3062   1 MSDEMHISSLVVQArpERLEAVAAALAALPGV-EVHASSEEGKLVVVIEAESQGALLDTI-EAIRALPGVL 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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