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Conserved domains on  [gi|491679603|ref|WP_005535745|]
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MULTISPECIES: cysteine hydrolase family protein [Vibrio]

Protein Classification

cysteine hydrolase family protein( domain architecture ID 10099067)

cysteine hydrolase family protein related to isochorismatase and nicotinamidase; catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue

EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 4-153 3.76e-52

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


:

Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 163.53  E-value: 3.76e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   4 AVLVIDVQSILFDPEPQPFESQIVLTKINEVTKLARAKSVPVIFVQHEQPK-SVIEYESAGWALQSSLITQTGDHFVRKT 82
Cdd:cd01014    1 ALLVIDVQNGYFDGGLPPLNNEAALENIAALIAAARAAGIPVIHVRHIDDEgGSFAPGSEGWEIHPELAPLEGETVIEKT 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491679603  83 TPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDK----EHASGAQIREHH 153
Cdd:cd01014   81 VPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFDLpdhgGVLSAEEIHAHY 155
 
Name Accession Description Interval E-value
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 4-153 3.76e-52

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 163.53  E-value: 3.76e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   4 AVLVIDVQSILFDPEPQPFESQIVLTKINEVTKLARAKSVPVIFVQHEQPK-SVIEYESAGWALQSSLITQTGDHFVRKT 82
Cdd:cd01014    1 ALLVIDVQNGYFDGGLPPLNNEAALENIAALIAAARAAGIPVIHVRHIDDEgGSFAPGSEGWEIHPELAPLEGETVIEKT 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491679603  83 TPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDK----EHASGAQIREHH 153
Cdd:cd01014   81 VPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFDLpdhgGVLSAEEIHAHY 155
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 4-167 7.48e-39

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 130.41  E-value: 7.48e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   4 AVLVIDVQSILFDPEP-QPFESQIVLTKINEVTKLARAKSVPVIFVQHEQPKSVIEY------------ESAGWALQSSL 70
Cdd:COG1335    1 ALLVIDVQNDFVPPGAlAVPGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFaefdlwpphcvpGTPGAELVPEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  71 ITQTGDHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDKehasgaqir 150
Cdd:COG1335   81 APLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP--------- 151

                        170
                 ....*....|....*..
gi 491679603 151 EHHNATLPSISSFGVKI 167
Cdd:COG1335  152 EAHEAALARLRAAGATV 168
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 3-147 2.94e-32

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 113.65  E-value: 2.94e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603    3 SAVLVIDVQS-ILFDPEPQPFESQIVLTKINEVTKLARAKSVPVIFVQHE------------QPKSVIEYESAGWALQSS 69
Cdd:pfam00857   1 TALLVIDMQNdFVDSGGPKVEGIAAILENINRLLKAARKAGIPVIFTRQVpepddadfalkdRPSPAFPPGTTGAELVPE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491679603   70 LITQTGDHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDKEHASGA 147
Cdd:pfam00857  81 LAPLPGDLVVDKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEAHDAA 158
PLN02621 PLN02621
nicotinamidase
 2-161 1.78e-14

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 67.88  E-value: 1.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   2 KSAVLVIDVQSiLFDPEPQPfesqiVLTKINEVTKLARAKSVPVIFVQHEQpKSVIEYESAG-W---------ALQSSLI 71
Cdd:PLN02621  20 QAALLVIDMQN-YFSSMAEP-----ILPALLTTIDLCRRASIPVFFTRHSH-KSPSDYGMLGeWwdgdlildgTTEAELM 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  72 TQTG-----DHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDKehasg 146
Cdd:PLN02621  93 PEIGrvtgpDEVVEKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATANE----- 167

                        170
                 ....*....|....*
gi 491679603 147 aqirEHHNATLPSIS 161
Cdd:PLN02621 168 ----ELHEATLKNLA 178
 
Name Accession Description Interval E-value
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 4-153 3.76e-52

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 163.53  E-value: 3.76e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   4 AVLVIDVQSILFDPEPQPFESQIVLTKINEVTKLARAKSVPVIFVQHEQPK-SVIEYESAGWALQSSLITQTGDHFVRKT 82
Cdd:cd01014    1 ALLVIDVQNGYFDGGLPPLNNEAALENIAALIAAARAAGIPVIHVRHIDDEgGSFAPGSEGWEIHPELAPLEGETVIEKT 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491679603  83 TPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDK----EHASGAQIREHH 153
Cdd:cd01014   81 VPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFDLpdhgGVLSAEEIHAHY 155
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 4-167 7.48e-39

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 130.41  E-value: 7.48e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   4 AVLVIDVQSILFDPEP-QPFESQIVLTKINEVTKLARAKSVPVIFVQHEQPKSVIEY------------ESAGWALQSSL 70
Cdd:COG1335    1 ALLVIDVQNDFVPPGAlAVPGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFaefdlwpphcvpGTPGAELVPEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  71 ITQTGDHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDKehasgaqir 150
Cdd:COG1335   81 APLPGDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRDP--------- 151

                        170
                 ....*....|....*..
gi 491679603 151 EHHNATLPSISSFGVKI 167
Cdd:COG1335  152 EAHEAALARLRAAGATV 168
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 4-150 1.93e-34

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 118.91  E-value: 1.93e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   4 AVLVIDVQSILFDPEPQPF-ESQIVLTKINEVTKLARAKSVPVIFVQHEQPKSVIEY-----------ESAGWALQSSLI 71
Cdd:cd00431    1 ALLVVDMQNDFVPGGGLLLpGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPEFaellwpphcvkGTEGAELVPELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  72 TQTGDHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDKE--HASGAQI 149
Cdd:cd00431   81 PLPDDLVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDACATRDEEdhEAALERL 160


                 .
gi 491679603 150 R 150
Cdd:cd00431  161 A 161
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 3-147 2.94e-32

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 113.65  E-value: 2.94e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603    3 SAVLVIDVQS-ILFDPEPQPFESQIVLTKINEVTKLARAKSVPVIFVQHE------------QPKSVIEYESAGWALQSS 69
Cdd:pfam00857   1 TALLVIDMQNdFVDSGGPKVEGIAAILENINRLLKAARKAGIPVIFTRQVpepddadfalkdRPSPAFPPGTTGAELVPE 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491679603   70 LITQTGDHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDKEHASGA 147
Cdd:pfam00857  81 LAPLPGDLVVDKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDACASLSPEAHDAA 158
PLN02621 PLN02621
nicotinamidase
 2-161 1.78e-14

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 67.88  E-value: 1.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   2 KSAVLVIDVQSiLFDPEPQPfesqiVLTKINEVTKLARAKSVPVIFVQHEQpKSVIEYESAG-W---------ALQSSLI 71
Cdd:PLN02621  20 QAALLVIDMQN-YFSSMAEP-----ILPALLTTIDLCRRASIPVFFTRHSH-KSPSDYGMLGeWwdgdlildgTTEAELM 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  72 TQTG-----DHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDKehasg 146
Cdd:PLN02621  93 PEIGrvtgpDEVVEKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATANE----- 167

                        170
                 ....*....|....*
gi 491679603 147 aqirEHHNATLPSIS 161
Cdd:PLN02621 168 ----ELHEATLKNLA 178
EntB1 COG1535
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
2-165 1.25e-12

Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441144 [Multi-domain]  Cd Length: 204  Bit Score: 62.95  E-value: 1.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   2 KSAVLVIDVQS--ILFDPEPQPfESQIVLTKINEVTKLARAKSVPVIFVQheQPKSVIEYESAGW--------------- 64
Cdd:COG1535   19 RAALLIHDMQNyfLRPYDPDEP-PIRELVANIARLRDACRAAGIPVVYTA--QPGDQTPEDRGLLndfwgpgltagpegq 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  65 ALQSSLITQTGDHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCG-YASeFCVDTTIRRAAGLGYPVTLVSDahtthdkeh 143
Cdd:COG1535   96 EIVDELAPAPGDTVLTKWRYSAFQRTDLEERLRELGRDQLIITGvYAH-IGCLATAVDAFMRDIQPFVVAD--------- 165

                        170       180
                 ....*....|....*....|...
gi 491679603 144 ASGAQIREHHNATLPSISS-FGV 165
Cdd:COG1535  166 AVADFSREEHRMALEYVAGrCGV 188
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 60-145 2.24e-10

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 57.00  E-value: 2.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  60 ESAGWALQSSLITQTGDHFVRKTTP---DS---FLN-----TNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYP 128
Cdd:PTZ00331  94 GTKGAQLHKDLVVERIDIIIRKGTNrdvDSysaFDNdkgskTGLAQILKAHGVRRVFICGLAFDFCVLFTALDAVKLGFK 173

                         90
                 ....*....|....*..
gi 491679603 129 VTLVSDAHTTHDKEHAS 145
Cdd:PTZ00331 174 VVVLEDATRAVDPDAIS 190
CSHase cd01015
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ...
 4-135 2.49e-08

N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.


Pssm-ID: 238497 [Multi-domain]  Cd Length: 179  Bit Score: 50.86  E-value: 2.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   4 AVLVIDVQSILFDPEP---QPFESQIVLTKinEVTKLARAKSVPVIF----VQHEQPKSVIEY----------ESAGW-A 65
Cdd:cd01015    1 ALLVIDLVEGYTQPGSylaPGIAAALENVQ--RLLAAARAAGVPVIHttvvYDPDGADGGLWArkvpamsdlvEGSPLaA 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  66 LQSSLITQTGDHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDA 135
Cdd:cd01015   79 ICDELAPQEDEMVLVKKYASAFFGTSLAATLTARGVDTLIVAGCSTSGCIRATAVDAMQHGFRPIVVREC 148
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 4-173 4.57e-08

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 49.90  E-value: 4.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   4 AVLVIDVQSILFdpePQPFESQIVLTKINEVTKLARAKSVPVIFVQHeqpksvieYESAGWALQSSLITQTGDHFV-RKT 82
Cdd:cd01012    1 ALLLVDVQEKLA---PAIKSFDELINNTVKLAKAAKLLDVPVILTEQ--------YPKGLGPTVPELREVFPDAPViEKT 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  83 TPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDahtthdkehASGAQIREHHNATLPSISS 162
Cdd:cd01012   70 SFSCWEDEAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVAD---------ACGSRSKEDHELALARMRQ 140

                        170
                 ....*....|.
gi 491679603 163 FGVKIEAVEAC 173
Cdd:cd01012  141 AGAVLTTSESV 151
PRK11440 PRK11440
putative hydrolase; Provisional
 2-147 3.38e-06

putative hydrolase; Provisional


Pssm-ID: 183137  Cd Length: 188  Bit Score: 45.11  E-value: 3.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   2 KSAVLVIDVQSILFDPEPQPFESQIVLTKINEVTKLARAKSVPVIFVQ-------HEQPKSVIEYESAG-------WALQ 67
Cdd:PRK11440   8 TTALVVIDLQEGILPFAGGPHTADEVVARAARLAAKFRASGSPVVLVRvgwsadyAEALKQPVDAPSPAkvlpenwWQHP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  68 SSLITQTGDHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYPVTLVSDAHTTHDKEHASGA 147
Cdd:PRK11440  88 AALGKTDSDIEVTKRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDACSAASAEQHQNS 167
nicotinamidase cd01011
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ...
 61-135 7.93e-05

Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).


Pssm-ID: 238493  Cd Length: 196  Bit Score: 41.48  E-value: 7.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  61 SAGWALQSSLITQTGDHFVRK-TTPDS-----------FLNTNLQSVLNELDVDSLIVCGYASEFCVDTTIRRAAGLGYP 128
Cdd:cd01011   86 TPGAELHPGLPVPDIDLIVRKgTNPDIdsysaffdndrRSSTGLAEYLRERGIDRVDVVGLATDYCVKATALDALKAGFE 165


                 ....*..
gi 491679603 129 VTLVSDA 135
Cdd:cd01011  166 VRVLEDA 172
isochorismatase cd01013
Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the ...
 2-119 1.14e-04

Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological systems. Isochorismatase is part of the phenazine biosynthesis pathway. Phenazines are antimicrobial compounds that provide the competitive advantage for certain bacteria.


Pssm-ID: 238495  Cd Length: 203  Bit Score: 40.78  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603   2 KSAVLVIDVQSILFDPEPQ---PFESqiVLTKINEVTKLARAKSVPVIFVQheQPKSVIEYESA------GWALQSS--- 69
Cdd:cd01013   29 RAVLLVHDMQRYFLDFYDEsaePVPQ--LIANIARLRDWCRQAGIPVVYTA--QPGNQTPEQRAllndfwGPGLTASpee 104

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 491679603  70 ------LITQTGDHFVRKTTPDSFLNTNLQSVLNELDVDSLIVCG-YASEFCVDTTI 119
Cdd:cd01013  105 tkivteLAPQPDDTVLTKWRYSAFKRSPLLERLKESGRDQLIITGvYAHIGCLSTAV 161
PRK11609 PRK11609
bifunctional nicotinamidase/pyrazinamidase;
44-134 5.04e-04

bifunctional nicotinamidase/pyrazinamidase;


Pssm-ID: 183228  Cd Length: 212  Bit Score: 39.20  E-value: 5.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491679603  44 PVIFVQHeqpksvieyeSAGWALQSSLITQTGDHFVRK-TTP--DS----FLN-----TNLQSVLNELDVDSLIVCGYAS 111
Cdd:PRK11609  83 PDHCVQN----------SEGAALHPLLNQKAIDAVFHKgENPliDSysafFDNghrqkTALDDWLREHGITELIVMGLAT 152

                         90       100
                 ....*....|....*....|...
gi 491679603 112 EFCVDTTIRRAAGLGYPVTLVSD 134
Cdd:PRK11609 153 DYCVKFTVLDALALGYQVNVITD 175
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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