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Conserved domains on  [gi|491853669|ref|WP_005634519|]
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MULTISPECIES: TonB-dependent receptor [Parabacteroides]

Protein Classification

TonB-dependent receptor( domain architecture ID 12077215)

TonB-dependent receptor similar to Bacteroides thetaiotaomicron starch-utilization system protein C (SusC), which mediates transport of starch oligosaccharides from the surface of the outer membrane to the periplasm for subsequent degradation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 134-1143 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


:

Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 747.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   134 KKISGQIVDTYGLAVIGANVVEKGTTNGTITDVDGNFSLEVDENSTLVVSYIGYTPQEIIVANKSNFSIKLKEDTEVLDE 213
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   214 VVVVGYGTAKKKDLTGAVSSVKAEKLSAQAPRNVQDILRSNAAGLNIgIATDAK--AEADLSVRGKGTLSAGSSPLIVLD 291
Cdd:TIGR04056   81 VVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVII-TQSSGEpgGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   292 GVIYEGNLSDITPEDIASVDVLKDASSSAVYGAKAANGVIAITTKKGIQGKPVINFNANISFAKSANQPKILDAEGFLKF 371
Cdd:TIGR04056  160 GVPRDNGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAEL 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   372 rqdYNEGRNSDeylakypqifvnpfklqGVDPLVWYnydqsvpatsvTDKQLETQWLSRLNLLTPEIDnyfagritkWDD 451
Cdd:TIGR04056  240 ---YNEALLNR-----------------GSSPPDIY-----------TDEEIEAYRNGLDPDLYPNTD---------WQD 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   452 LVF-QTGLQQDYTVSVSNATERTSQYYSLNWADREGIITGDKYTNFRARMNVKTEITSF--LSVGMNAQFSSRNE--GFL 526
Cdd:TIGR04056  280 EIFkRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTlkLSLNVSGSLSKYNNpgGST 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   527 KCLWEQ---MTMISPYGANEVDNLESPYRRNPTGMDPVNPFYDNMYTERKDLYQNLNAKLYAEVKLPFGIEYTLNFTPYY 603
Cdd:TIGR04056  360 SNIWGAlmlFPRGTPYSTPPVYSDGYYPAYNSGNTSLQNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDY 439

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   604 S---WHDYYNHYSSEGEKWEAIGGASVRTNTKQFSWQIDNIIRWKREFAqKHKVEVTLLANAEKAQYWSTTAEAQGYTPN 680
Cdd:TIGR04056  440 SnykNKKYYKNPYYYNATGGANNGYYSESNSRSRNYYLEATLNYNRTFG-KHNVSALLGYSQQENKSSSYGGLLDDLPSL 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   681 DVLGyhqlQSGSVQKVSSDDTYQtgdALMARLFYSFNNKYMLTTSIRRDGYSAFGKKNPRATFPSVALGWVFTQEQFMQQ 760
Cdd:TIGR04056  519 DAGT----SDASVSGSDSEYRLQ---SLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKK 591

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   761 ANSWLNYAKLRISWGENGNRDIG-QYAALAQMKSSLRPYIDQTGNIYTISQMFVNTMANHNLKWERTAAFNFGLDFSLFD 839
Cdd:TIGR04056  592 LKKWLSFLKLRASYGIVGNDNIGdRYPYLSLYNLGDGGYNFGTNNGTSVTGITESRYGNPNLKWEKTKKWNLGLDLGFFN 671

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   840 ELLSGSIETYVSKTNDLLVKRALPDVTGFNSVTANLGQLQNKGFELTLNANIINSKDFKWFASGNFSLNRRKINSLYGdm 919
Cdd:TIGR04056  672 NRLSLTVDYYYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDE-- 749

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   920 vdvldengnviGQKESDDETNKWFIGQDPDRIWDYERAGVWQKDEREEAAIYGCQPGDFKYVDQNGDGIMNNKDKVFQGY 999
Cdd:TIGR04056  750 -----------GAYLPVKYPYISKEGGPIGQIYGYIADGLFKDDDSPKQTFGNVRPGDIKYKDVNGDGKIDDDDRVPIGY 818

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  1000 T-TPRFRWTLRNEWTYKNLSLSAVLYSYLGHYgAFQRAANNYSFPDRTSDYDFP-----RWTATNPINDYARIGSKNIGT 1073
Cdd:TIGR04056  819 SnTPDLTYGFGNSFSYKGFDLSALFQGSGGGD-VFNDGRGFYPFNGGDWGNVLKivadnRWTPENPNADYPRLSYGDSNN 897

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  1074 NY---------VNKSFVRLENVTLSYHFPKEWINKFAIQSLRLSGSIQNAAVFAPHwNFWDPESGSV------TPRTFNL 1138
Cdd:TIGR04056  898 SNnyqastrwlEDGSYLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFSKY-KGWDPELQGNdggaypLQRTFSF 976


                   ....*
gi 491853669  1139 GINVT 1143
Cdd:TIGR04056  977 GVNLT 981
STN pfam07660
Secretin and TonB N terminus short domain; This is a short domain found at the N-terminus of ...
 74-120 3.22e-07

Secretin and TonB N terminus short domain; This is a short domain found at the N-terminus of the Secretins of the bacterial type II/III secretory system as well as the TonB-dependent receptor proteins. These proteins are involved in TonB-dependent active uptake of selective substrates.


:

Pssm-ID: 429580 [Multi-domain]  Cd Length: 51  Bit Score: 47.90  E-value: 3.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 491853669    74 VVFRDQDVDVNKTVSFNTKTATVADYLEMITKNTGISYQFENNYITL 120
Cdd:pfam07660    2 ILYDSDLVDGKQSVSLNVGNVTLEEALDQLLAGTGLSYEIGGNTIVL 48
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 134-1143 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 747.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   134 KKISGQIVDTYGLAVIGANVVEKGTTNGTITDVDGNFSLEVDENSTLVVSYIGYTPQEIIVANKSNFSIKLKEDTEVLDE 213
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   214 VVVVGYGTAKKKDLTGAVSSVKAEKLSAQAPRNVQDILRSNAAGLNIgIATDAK--AEADLSVRGKGTLSAGSSPLIVLD 291
Cdd:TIGR04056   81 VVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVII-TQSSGEpgGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   292 GVIYEGNLSDITPEDIASVDVLKDASSSAVYGAKAANGVIAITTKKGIQGKPVINFNANISFAKSANQPKILDAEGFLKF 371
Cdd:TIGR04056  160 GVPRDNGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAEL 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   372 rqdYNEGRNSDeylakypqifvnpfklqGVDPLVWYnydqsvpatsvTDKQLETQWLSRLNLLTPEIDnyfagritkWDD 451
Cdd:TIGR04056  240 ---YNEALLNR-----------------GSSPPDIY-----------TDEEIEAYRNGLDPDLYPNTD---------WQD 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   452 LVF-QTGLQQDYTVSVSNATERTSQYYSLNWADREGIITGDKYTNFRARMNVKTEITSF--LSVGMNAQFSSRNE--GFL 526
Cdd:TIGR04056  280 EIFkRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTlkLSLNVSGSLSKYNNpgGST 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   527 KCLWEQ---MTMISPYGANEVDNLESPYRRNPTGMDPVNPFYDNMYTERKDLYQNLNAKLYAEVKLPFGIEYTLNFTPYY 603
Cdd:TIGR04056  360 SNIWGAlmlFPRGTPYSTPPVYSDGYYPAYNSGNTSLQNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDY 439

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   604 S---WHDYYNHYSSEGEKWEAIGGASVRTNTKQFSWQIDNIIRWKREFAqKHKVEVTLLANAEKAQYWSTTAEAQGYTPN 680
Cdd:TIGR04056  440 SnykNKKYYKNPYYYNATGGANNGYYSESNSRSRNYYLEATLNYNRTFG-KHNVSALLGYSQQENKSSSYGGLLDDLPSL 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   681 DVLGyhqlQSGSVQKVSSDDTYQtgdALMARLFYSFNNKYMLTTSIRRDGYSAFGKKNPRATFPSVALGWVFTQEQFMQQ 760
Cdd:TIGR04056  519 DAGT----SDASVSGSDSEYRLQ---SLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKK 591

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   761 ANSWLNYAKLRISWGENGNRDIG-QYAALAQMKSSLRPYIDQTGNIYTISQMFVNTMANHNLKWERTAAFNFGLDFSLFD 839
Cdd:TIGR04056  592 LKKWLSFLKLRASYGIVGNDNIGdRYPYLSLYNLGDGGYNFGTNNGTSVTGITESRYGNPNLKWEKTKKWNLGLDLGFFN 671

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   840 ELLSGSIETYVSKTNDLLVKRALPDVTGFNSVTANLGQLQNKGFELTLNANIINSKDFKWFASGNFSLNRRKINSLYGdm 919
Cdd:TIGR04056  672 NRLSLTVDYYYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDE-- 749

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   920 vdvldengnviGQKESDDETNKWFIGQDPDRIWDYERAGVWQKDEREEAAIYGCQPGDFKYVDQNGDGIMNNKDKVFQGY 999
Cdd:TIGR04056  750 -----------GAYLPVKYPYISKEGGPIGQIYGYIADGLFKDDDSPKQTFGNVRPGDIKYKDVNGDGKIDDDDRVPIGY 818

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  1000 T-TPRFRWTLRNEWTYKNLSLSAVLYSYLGHYgAFQRAANNYSFPDRTSDYDFP-----RWTATNPINDYARIGSKNIGT 1073
Cdd:TIGR04056  819 SnTPDLTYGFGNSFSYKGFDLSALFQGSGGGD-VFNDGRGFYPFNGGDWGNVLKivadnRWTPENPNADYPRLSYGDSNN 897

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  1074 NY---------VNKSFVRLENVTLSYHFPKEWINKFAIQSLRLSGSIQNAAVFAPHwNFWDPESGSV------TPRTFNL 1138
Cdd:TIGR04056  898 SNnyqastrwlEDGSYLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFSKY-KGWDPELQGNdggaypLQRTFSF 976


                   ....*
gi 491853669  1139 GINVT 1143
Cdd:TIGR04056  977 GVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
211-921 2.87e-42

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 165.39  E-value: 2.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  211 LDEVVVVGYGTA-KKKDLTGAVSSVKAEKLSAQAPRNVQDILRsNAAGLNIGiaTDAKAEADLSVRGKGtlSAGSSPLIV 289
Cdd:COG1629     1 LEEVVVTATRTDeSLQDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVT--SAGGGAGQISIRGFG--GGGNRVLVL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  290 LDGV------IYEGNLSDITPEDIASVDVLKDASSsAVYGAKAANGVIAITTKKGIQGKpviNFNANISFAksanqpkil 363
Cdd:COG1629    76 VDGVplndpsGGDGGLSYIDPEDIERVEVLRGPSS-ALYGSGALGGVINIVTKKPKDGK---GGEVSASYG--------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  364 daegflkfrqdynegrnsdeylakypqifvnpfklqgvdplvwyNYDQsvpatsvtdkqletqwlsrlnlltpeidnyfa 443
Cdd:COG1629   143 --------------------------------------------SYGT-------------------------------- 146

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  444 gritkwddlvfqtglqQDYTVSVSNATERTSQYYSLNWADREGIITGDKYTNFRARMNVKTEITSFLSVGMNAQFSSRNe 523
Cdd:COG1629   147 ----------------YRASLSLSGGNGKLAYRLSASYRDSDGYRDNSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSD- 209

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  524 gflkclweqmtmiSPYGANEVDNLESPYRRNPTGMDPvnpfYDNMYTERKDLYQNLNAKLyaevkLPFGIEYTLNFTPYY 603
Cdd:COG1629   210 -------------QDSPGYLTLAALRPRGAMDDGTNP----YSNDTDDNTRDRYSLSLEY-----EHLGDGLKLSASAYY 267

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  604 SWHDyyNHYSSEGEKWEAIGGASVRTNTKQFSWQIDNIIRWKREFAQKHKVEVtllanaeKAQYWSTTAEAQGYTPNDVL 683
Cdd:COG1629   268 RYDD--TDLDSDFTPTPADGGTLEQTDFDNRTYGLELRLTYDLGFGGKHTLLV-------GLDYQRQDLDGSGYPLDLGS 338

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  684 GyhqlQSGSVQKVSSDDTYQTGDALMARLFYSFNNKYMLTTSIRRDGYSAF------------GKKNPRATFPSVALGWV 751
Cdd:COG1629   339 G----SLPTLTSGADDDGTTTSLALYAQDTYKLTDKLTLTAGLRYDYVSYDvddtvtgtdsasGSRSYSAFSPSLGLTYQ 414

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  752 FTQEQfmqqanswlnyaKLRISWGENGNRdigqyaalaqmksslrpyidQTGNIYTISQMFVNTMANHNLKWERTAAFNF 831
Cdd:COG1629   415 LSPNL------------SLYASYSRGFRA--------------------PTFGELYANGTDPYSVGNPDLKPETSTNYEL 462

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  832 GLDFSLFDELLSGSIETYVSKTNDLLVKRALPDVTGFNSVTANLGQLQNKGFELTLNANIINskdfKWFASGNFSLNRRK 911
Cdd:COG1629   463 GLRYRLLDGRLSLSLALFYSDVDNEILSVPLPNDSGFSTYYTNAGKARSYGVELELSYQLTP----GLSLNASYSYTDAK 538

                         730
                  ....*....|
gi 491853669  912 INSLYGDMVD 921
Cdd:COG1629   539 FDDDTDGSAD 548
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 136-216 6.99e-20

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 85.34  E-value: 6.99e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   136 ISGQIVDTY-GLAVIGANVVEKGTTNGTITDVDGNFSLEVDENS--TLVVSYIGYTPQEIIVANKSNFSIK----LKEDT 208
Cdd:pfam13715    1 ISGTVVDENtGEPLPGATVYVKGTTKGTVTDADGNFELKNLPAGtyTLVVSFVGYKTQEKKVTVSNDNTLDvnflLKEDA 80


                   ....*...
gi 491853669   209 EVLDEVVV 216
Cdd:pfam13715   81 LLLDEVVV 88
STN pfam07660
Secretin and TonB N terminus short domain; This is a short domain found at the N-terminus of ...
 74-120 3.22e-07

Secretin and TonB N terminus short domain; This is a short domain found at the N-terminus of the Secretins of the bacterial type II/III secretory system as well as the TonB-dependent receptor proteins. These proteins are involved in TonB-dependent active uptake of selective substrates.


Pssm-ID: 429580 [Multi-domain]  Cd Length: 51  Bit Score: 47.90  E-value: 3.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 491853669    74 VVFRDQDVDVNKTVSFNTKTATVADYLEMITKNTGISYQFENNYITL 120
Cdd:pfam07660    2 ILYDSDLVDGKQSVSLNVGNVTLEEALDQLLAGTGLSYEIGGNTIVL 48
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 231-337 2.46e-05

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 48.60  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  231 VSSVKAEKLSAQAPRNVQDILRsNAAGLNIGiaTDAKAEAD-LSVRGkgtlSAGSSPLIVLDGV-------IYEGNLSDI 302
Cdd:cd01347     2 VSVITAEDIEKQPATSLADLLR-RIPGVSVT--RGGGGGGStISIRG----FGPDRTLVLVDGLplassnyGRGVDLNTI 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 491853669  303 TPEDIASVDVLKDAsSSAVYGAKAANGVIAITTKK 337
Cdd:cd01347    75 PPELIERVEVLKGP-SSALYGSGAIGGVVNIITKR 108
PRK13486 PRK13486
TonB-dependent receptor;
198-337 9.12e-05

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 46.55  E-value: 9.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  198 SNFSIKLKEDTEVldeVVVVGYgtakKKDLTGAVSSVKA---EKLSAQAPRNVQDILRSnAAGLNIGIATDAKAEADLSV 274
Cdd:PRK13486   17 SASSIAAAEDVMI---VSASGY----EKKLTNAAASVSVisqEELQSSQYHDLAEALRS-VEGVDVESGTGKTGGLEISI 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491853669  275 RGKgtlsAGSSPLIVLDGViYEGNLSDITPEDIAS--------------VDVLKdASSSAVYGAKAANGVIAITTKK 337
Cdd:PRK13486   89 RGM----PASYTLILIDGV-RQGGSSDVTPNGFSAmntgfmpplaaierIEVIR-GPMSTLYGSDAMGGVVNIITRK 159
STN smart00965
Secretin and TonB N terminus short domain; This is a short domain found at the N-terminus of ...
 72-120 9.55e-03

Secretin and TonB N terminus short domain; This is a short domain found at the N-terminus of the Secretins of the bacterial type II/III secretory system as well as the TonB-dependent receptor proteins. These proteins are involved in TonB-dependent active uptake of selective substrates.


Pssm-ID: 198033 [Multi-domain]  Cd Length: 52  Bit Score: 35.56  E-value: 9.55e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 491853669     72 YLVVFRDQDVdVNKTVSFNTKTATVADYLEMITKNTGISYQF-ENNYITL 120
Cdd:smart00965    1 LNFVYDPALV-AGRRVSLLLGNVTVEQALDRLLAGTGLTYRRiGGNTIVL 49
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 134-1143 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 747.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   134 KKISGQIVDTYGLAVIGANVVEKGTTNGTITDVDGNFSLEVDENSTLVVSYIGYTPQEIIVANKSNFSIKLKEDTEVLDE 213
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   214 VVVVGYGTAKKKDLTGAVSSVKAEKLSAQAPRNVQDILRSNAAGLNIgIATDAK--AEADLSVRGKGTLSAGSSPLIVLD 291
Cdd:TIGR04056   81 VVVVGYGTQKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVII-TQSSGEpgGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   292 GVIYEGNLSDITPEDIASVDVLKDASSSAVYGAKAANGVIAITTKKGIQGKPVINFNANISFAKSANQPKILDAEGFLKF 371
Cdd:TIGR04056  160 GVPRDNGLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKPKISYNAEFGFSTPTRLPEMLNAYEYAEL 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   372 rqdYNEGRNSDeylakypqifvnpfklqGVDPLVWYnydqsvpatsvTDKQLETQWLSRLNLLTPEIDnyfagritkWDD 451
Cdd:TIGR04056  240 ---YNEALLNR-----------------GSSPPDIY-----------TDEEIEAYRNGLDPDLYPNTD---------WQD 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   452 LVF-QTGLQQDYTVSVSNATERTSQYYSLNWADREGIITGDKYTNFRARMNVKTEITSF--LSVGMNAQFSSRNE--GFL 526
Cdd:TIGR04056  280 EIFkRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTlkLSLNVSGSLSKYNNpgGST 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   527 KCLWEQ---MTMISPYGANEVDNLESPYRRNPTGMDPVNPFYDNMYTERKDLYQNLNAKLYAEVKLPFGIEYTLNFTPYY 603
Cdd:TIGR04056  360 SNIWGAlmlFPRGTPYSTPPVYSDGYYPAYNSGNTSLQNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDY 439

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   604 S---WHDYYNHYSSEGEKWEAIGGASVRTNTKQFSWQIDNIIRWKREFAqKHKVEVTLLANAEKAQYWSTTAEAQGYTPN 680
Cdd:TIGR04056  440 SnykNKKYYKNPYYYNATGGANNGYYSESNSRSRNYYLEATLNYNRTFG-KHNVSALLGYSQQENKSSSYGGLLDDLPSL 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   681 DVLGyhqlQSGSVQKVSSDDTYQtgdALMARLFYSFNNKYMLTTSIRRDGYSAFGKKNPRATFPSVALGWVFTQEQFMQQ 760
Cdd:TIGR04056  519 DAGT----SDASVSGSDSEYRLQ---SLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKK 591

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   761 ANSWLNYAKLRISWGENGNRDIG-QYAALAQMKSSLRPYIDQTGNIYTISQMFVNTMANHNLKWERTAAFNFGLDFSLFD 839
Cdd:TIGR04056  592 LKKWLSFLKLRASYGIVGNDNIGdRYPYLSLYNLGDGGYNFGTNNGTSVTGITESRYGNPNLKWEKTKKWNLGLDLGFFN 671

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   840 ELLSGSIETYVSKTNDLLVKRALPDVTGFNSVTANLGQLQNKGFELTLNANIINSKDFKWFASGNFSLNRRKINSLYGdm 919
Cdd:TIGR04056  672 NRLSLTVDYYYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDE-- 749

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   920 vdvldengnviGQKESDDETNKWFIGQDPDRIWDYERAGVWQKDEREEAAIYGCQPGDFKYVDQNGDGIMNNKDKVFQGY 999
Cdd:TIGR04056  750 -----------GAYLPVKYPYISKEGGPIGQIYGYIADGLFKDDDSPKQTFGNVRPGDIKYKDVNGDGKIDDDDRVPIGY 818

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  1000 T-TPRFRWTLRNEWTYKNLSLSAVLYSYLGHYgAFQRAANNYSFPDRTSDYDFP-----RWTATNPINDYARIGSKNIGT 1073
Cdd:TIGR04056  819 SnTPDLTYGFGNSFSYKGFDLSALFQGSGGGD-VFNDGRGFYPFNGGDWGNVLKivadnRWTPENPNADYPRLSYGDSNN 897

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  1074 NY---------VNKSFVRLENVTLSYHFPKEWINKFAIQSLRLSGSIQNAAVFAPHwNFWDPESGSV------TPRTFNL 1138
Cdd:TIGR04056  898 SNnyqastrwlEDGSYLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFSKY-KGWDPELQGNdggaypLQRTFSF 976


                   ....*
gi 491853669  1139 GINVT 1143
Cdd:TIGR04056  977 GVNLT 981
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
211-921 2.87e-42

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 165.39  E-value: 2.87e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  211 LDEVVVVGYGTA-KKKDLTGAVSSVKAEKLSAQAPRNVQDILRsNAAGLNIGiaTDAKAEADLSVRGKGtlSAGSSPLIV 289
Cdd:COG1629     1 LEEVVVTATRTDeSLQDVPGSVSVISREQLEDQPATDLGDLLR-RVPGVSVT--SAGGGAGQISIRGFG--GGGNRVLVL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  290 LDGV------IYEGNLSDITPEDIASVDVLKDASSsAVYGAKAANGVIAITTKKGIQGKpviNFNANISFAksanqpkil 363
Cdd:COG1629    76 VDGVplndpsGGDGGLSYIDPEDIERVEVLRGPSS-ALYGSGALGGVINIVTKKPKDGK---GGEVSASYG--------- 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  364 daegflkfrqdynegrnsdeylakypqifvnpfklqgvdplvwyNYDQsvpatsvtdkqletqwlsrlnlltpeidnyfa 443
Cdd:COG1629   143 --------------------------------------------SYGT-------------------------------- 146

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  444 gritkwddlvfqtglqQDYTVSVSNATERTSQYYSLNWADREGIITGDKYTNFRARMNVKTEITSFLSVGMNAQFSSRNe 523
Cdd:COG1629   147 ----------------YRASLSLSGGNGKLAYRLSASYRDSDGYRDNSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSD- 209

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  524 gflkclweqmtmiSPYGANEVDNLESPYRRNPTGMDPvnpfYDNMYTERKDLYQNLNAKLyaevkLPFGIEYTLNFTPYY 603
Cdd:COG1629   210 -------------QDSPGYLTLAALRPRGAMDDGTNP----YSNDTDDNTRDRYSLSLEY-----EHLGDGLKLSASAYY 267

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  604 SWHDyyNHYSSEGEKWEAIGGASVRTNTKQFSWQIDNIIRWKREFAQKHKVEVtllanaeKAQYWSTTAEAQGYTPNDVL 683
Cdd:COG1629   268 RYDD--TDLDSDFTPTPADGGTLEQTDFDNRTYGLELRLTYDLGFGGKHTLLV-------GLDYQRQDLDGSGYPLDLGS 338

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  684 GyhqlQSGSVQKVSSDDTYQTGDALMARLFYSFNNKYMLTTSIRRDGYSAF------------GKKNPRATFPSVALGWV 751
Cdd:COG1629   339 G----SLPTLTSGADDDGTTTSLALYAQDTYKLTDKLTLTAGLRYDYVSYDvddtvtgtdsasGSRSYSAFSPSLGLTYQ 414

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  752 FTQEQfmqqanswlnyaKLRISWGENGNRdigqyaalaqmksslrpyidQTGNIYTISQMFVNTMANHNLKWERTAAFNF 831
Cdd:COG1629   415 LSPNL------------SLYASYSRGFRA--------------------PTFGELYANGTDPYSVGNPDLKPETSTNYEL 462

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  832 GLDFSLFDELLSGSIETYVSKTNDLLVKRALPDVTGFNSVTANLGQLQNKGFELTLNANIINskdfKWFASGNFSLNRRK 911
Cdd:COG1629   463 GLRYRLLDGRLSLSLALFYSDVDNEILSVPLPNDSGFSTYYTNAGKARSYGVELELSYQLTP----GLSLNASYSYTDAK 538

                         730
                  ....*....|
gi 491853669  912 INSLYGDMVD 921
Cdd:COG1629   539 FDDDTDGSAD 548
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 204-913 3.14e-34

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 140.38  E-value: 3.14e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  204 LKEDTEVLDEVVVVGYGTAKK-KDLTGAVSSVKAEKLSAQAPRNVQDILRsNAAGLNIGIATDAKAEADLSVRGkgtlSA 282
Cdd:COG4771    20 LAEDATELEEVVVTATRTEQSlSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGGRGGSSGISIRG----LG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  283 GSSPLIVLDGV-------IYEGNLSDITPEDIASVDVLKDASSsAVYGAKAANGVIAITTKKGiqgkpvinfnanisfak 355
Cdd:COG4771    95 GDRVLVLIDGVpvnnpalGGGGDLSYIPPDDIERIEVIRGPAS-ALYGSDAIGGVINIITKKP----------------- 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  356 sanqpkildaegflkfrQDYNEGRnsdeylakypqifvnpfklqgvdplVWYNYDQsvpatsvtdkqletqwlsrlnllt 435
Cdd:COG4771   157 -----------------TDELEGS-------------------------VSLGYGS------------------------ 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  436 peidnyfagritkwddlvfQTGLQQDYTVSVSNATERTSQYYSLNWADREGIITgdkYTNFRARMNVKTEITSFLsVGMN 515
Cdd:COG4771   171 -------------------NGNGTYSGSLSLGGPGDKLSFLLSGSYRDRDGYLD---YRNGGFVGNSGYERYNLN-AKLG 227

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  516 AQFSSRNEGFLKclweqmtmispYGANEVDNLESPYRRNPTGMDPVNPFYDNMYTERKDlyqnlnaklyaevklpFGIEY 595
Cdd:COG4771   228 YRLSDNHRLSLS-----------GGYSRQDRDGGPPTLGDTEISSDNAGDRDTTTDRGN----------------YSLRY 280

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  596 TLNFTPYYSWHDYYNHYSSEGEKWEAIGGASVRTNTKQFSWQIDniIRWKREFAQKHKVEVTllanaekAQYWSTTAEAQ 675
Cdd:COG4771   281 NGDLGDNLDLSLYYSRTDRDSTNGSLGGSTGSFSDSDDTTYGLE--LDLTYPLGGNHTLTLG-------AEYRYDDLDSS 351

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  676 GYTPNDVLGYHQLqsgsvqkvssddtyqtgdALMARLFYSFNNKYMLTTSIRRDGYSAFGKKNPRATFPSVALGWVFTQE 755
Cdd:COG4771   352 SFLGGADASRDTY------------------GLFAQDEWKLTDKLTLTAGLRYDYYSTFGASNYTAFSPRLGLRYDLSDN 413

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  756 QfmqqanswlnyaKLRISWGEnGNRdigqyaalaqmksslRPYIDQTGNIYTISQmFVNTMANHNLKWERTAAFNFGLDF 835
Cdd:COG4771   414 L------------TLRASYGR-GFR---------------APSLAELYGSGTGTP-GRYVLGNPDLKPETSDNYELGLEY 464

                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491853669  836 SLFDELLSGSIETYVSKTNDLLVKRALPDVTGFNSVTANLGQLQNKGFELTLNANIINskdfKWFASGNFSLNRRKIN 913
Cdd:COG4771   465 RLGNGGLSLSLTGFYTDIKDLIVLVPVGPGPGDVLQYENVGKARTYGLELELKYRLGK----GLTLTASYTYLDSKID 538
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
214-389 4.32e-27

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 112.27  E-value: 4.32e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  214 VVVVGYGTA-KKKDLTGAVSSVKAEKLSAQAPRNVQDILRsNAAGLNIGIATDAKAEADLSVRGKGTlsagSSPLIVLDG 292
Cdd:COG4206     1 VVVTATRLEqSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQVSSSGGPGSAASISIRGLGS----NQTLVLIDG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  293 VIYEG------NLSDITPEDIASVDVLKDASSsAVYGAKAANGVIAITTKKGIQG-KPVINFNANiSFAKSANQPKILDA 365
Cdd:COG4206    76 VPLNDpslggvDLSLIPPDDIERIEVLKGAAS-ALYGSDAIGGVINITTKKGKKGfKGSVSASYG-SFGTRRLSASLSGG 153

                         170       180
                  ....*....|....*....|....
gi 491853669  366 EGFLKFRQDYNeGRNSDEYLAKYP 389
Cdd:COG4206   154 AGKFSYSLSAS-YRRSDGYRYNDP 176
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 136-216 6.99e-20

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 85.34  E-value: 6.99e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   136 ISGQIVDTY-GLAVIGANVVEKGTTNGTITDVDGNFSLEVDENS--TLVVSYIGYTPQEIIVANKSNFSIK----LKEDT 208
Cdd:pfam13715    1 ISGTVVDENtGEPLPGATVYVKGTTKGTVTDADGNFELKNLPAGtyTLVVSFVGYKTQEKKVTVSNDNTLDvnflLKEDA 80


                   ....*...
gi 491853669   209 EVLDEVVV 216
Cdd:pfam13715   81 LLLDEVVV 88
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 223-330 6.88e-18

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 80.01  E-value: 6.88e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   223 KKKDLTGAVSSVKAEKLSAQAPRNVQDILRsNAAGLNIGIATDAKAeADLSVRGkgtlSAGSSPLIVLDGV------IYE 296
Cdd:pfam07715    1 DLRDTPGSVSVVTAEDIEDQGATNLADALR-GVPGVSVSSGGGGGG-SSISIRG----FGSNRVLVLVDGVplnsggGGS 74

                           90       100       110
                   ....*....|....*....|....*....|....
gi 491853669   297 GNLSDITPEDIASVDVLKDAsSSAVYGAKAANGV 330
Cdd:pfam07715   75 VDLNSIDPEDIERVEVLKGP-ASALYGSGAIGGV 107
SusC_RagA_signa TIGR04057
TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model ...
 306-336 1.32e-11

TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model describes a 31-residue signature region of the SusC/RagA family of outer membrane proteins from the Bacteriodetes. While many TonB-dependent outer membrane receptors are associated with siderophore import, this family seems to include generalized nutrient receptors that may convey fairly large oligomers of protein or carbohydrate. This family occurs in high copy numbers in the most abundant species of the human gut microbiome.


Pssm-ID: 274949 [Multi-domain]  Cd Length: 31  Bit Score: 59.90  E-value: 1.32e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 491853669   306 DIASVDVLKDASSSAVYGAKAANGVIAITTK 336
Cdd:TIGR04057    1 DIESISVLKDASAAAIYGSRGANGVILITTK 31
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 539-891 1.01e-09

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 62.48  E-value: 1.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   539 YGANEVDNLESPYRRNPTGMDPVNPFYDNMYTERKDLYQNLNAKLYAEVKLPFGIEYTLNFTPYYSWHDYYNHYSSegeK 618
Cdd:pfam00593   21 YSRYTDGLDLGLTLDGYGNDGGYLGDRPLYYGRDYSDTDRKRLSLGYDYDLGDGLSWLSTLRLGLRYSSLDGDYTS---N 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   619 WEAIGGASVRTNTKQFSWQIDNIIRWKREFAQKHKVEVTLLANAEKAQYWSTTAEAQGYTPNDVLGYhqlqsgsvqkVSS 698
Cdd:pfam00593   98 SSGLSGAGDYLSDDRLYGLYGLDGDLELSLDLSHDLLLGVELRTAGLDYRRLDDDAYDPYDPANPSS----------SSY 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   699 DDTYQTGDALMARLFYSFNNKYMLTTSIRRDGYSAFGK----------KNPRATFPSVALGWVFTQEQfmqqanswlnya 768
Cdd:pfam00593  168 SDTTTDSYGLYLQDNIKLTDRLTLTLGLRYDHYSTDGDdgngggdnfsRSYSAFSPRLGLVYKPTDNL------------ 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   769 KLRISWGENGNRdigqyaalaqmksslrPYIDQTGNIYTISQMFVNTMANHNLKWERTAAFNFGLDFslFDELLSGSIET 848
Cdd:pfam00593  236 SLYASYSRGFRA----------------PSLGELYGSGSGGGGGAVAGGNPDLKPETSDNYELGLKY--DDGRLSLSLAL 297

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 491853669   849 YVSKTNDLLVKRAL-PDVTGFNSVTANLGQLQNKGFELTLNANI 891
Cdd:pfam00593  298 FYIDIKNLITSDPDgPGLGGTVYTYTNVGKARIRGVELELSGRL 341
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
206-338 1.06e-09

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 62.64  E-value: 1.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  206 EDTEVLDEVVVVGYGTAKK--KDLTGAVSSVKAEKLSAQAPRNVQDILRSnAAGLNIGIATDAKAEADLSVRGkgtLSAG 283
Cdd:COG4772    18 EAATTLETVVVTGSRAAEArlKDVPGSVSVVDREELENQAATSLREVLRR-VPGVNVQEEDGFGLRPNIGIRG---LGPR 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491853669  284 SSP--LIVLDGV-----IYEGNLSDITP--EDIASVDVLKDAsSSAVYGAKAANGVIAITTKKG 338
Cdd:COG4772    94 RSRgiTLLEDGIpiapaPYGDPAAYYFPdlERMERIEVLRGA-AALRYGPQTVGGAINFVTRTI 156
STN pfam07660
Secretin and TonB N terminus short domain; This is a short domain found at the N-terminus of ...
 74-120 3.22e-07

Secretin and TonB N terminus short domain; This is a short domain found at the N-terminus of the Secretins of the bacterial type II/III secretory system as well as the TonB-dependent receptor proteins. These proteins are involved in TonB-dependent active uptake of selective substrates.


Pssm-ID: 429580 [Multi-domain]  Cd Length: 51  Bit Score: 47.90  E-value: 3.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 491853669    74 VVFRDQDVDVNKTVSFNTKTATVADYLEMITKNTGISYQFENNYITL 120
Cdd:pfam07660    2 ILYDSDLVDGKQSVSLNVGNVTLEEALDQLLAGTGLSYEIGGNTIVL 48
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
136-192 4.39e-07

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 48.43  E-value: 4.39e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491853669   136 ISGQIVDTYGLAVIGANVV----EKGTTNGTITDVDGNFSLEVDENS--TLVVSYIGYTPQEI 192
Cdd:pfam13620    2 ISGTVTDPSGAPVPGATVTvtntDTGTVRTTTTDADGRYRFPGLPPGtyTVTVSAPGFKTATR 64
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 178-337 9.58e-07

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 52.97  E-value: 9.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  178 STLVVSYIGYTPQEIIVANKSNFSiklkEDTEVLDEVVVVGYGTAKKKDLTG-----------------AVSSVKAEKLS 240
Cdd:COG4773     3 ALLAGSGLAAAAAGALAQAAAAAA----AEATTLPEVTVTGTAEGTGGYTAKssstatkldtplretpqSVSVVTRQLIE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  241 AQAPRNVQDILRsNAAGLNIGiATDAKAEADLSVRGkgtlsaGSSPLIVLDGV-IYEGNLSDITPEDIASVDVLKDASSs 319
Cdd:COG4773    79 DQGATTLDDALR-NVPGVTVS-SYDGGGRDSFSIRG------FSIDNYLRDGLpLGGFGGGQPDTANLERVEVLKGPAG- 149

                         170
                  ....*....|....*...
gi 491853669  320 AVYGAKAANGVIAITTKK 337
Cdd:COG4773   150 LLYGAGSPGGLVNLVTKR 167
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
230-337 3.69e-06

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 51.03  E-value: 3.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  230 AVSSVKAEKLSAQAPRNVQDILRsNAAGLNIGIATDAKAEaDLSVRGkgtLSAGSSplIVLDGvIYEGNLSDITPEDIAS 309
Cdd:COG4774    12 SVTVVTRELIEDQGATSLADALR-NVPGVTFGAGEGGNGD-SFSIRG---FSASGD--IYVDG-LRDPGQYRRDTFNLER 83

                          90       100
                  ....*....|....*....|....*...
gi 491853669  310 VDVLKdASSSAVYGAKAANGVIAITTKK 337
Cdd:COG4774    84 VEVLK-GPASVLYGRGSPGGVINLVTKR 110
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 231-337 2.46e-05

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 48.60  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  231 VSSVKAEKLSAQAPRNVQDILRsNAAGLNIGiaTDAKAEAD-LSVRGkgtlSAGSSPLIVLDGV-------IYEGNLSDI 302
Cdd:cd01347     2 VSVITAEDIEKQPATSLADLLR-RIPGVSVT--RGGGGGGStISIRG----FGPDRTLVLVDGLplassnyGRGVDLNTI 74

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 491853669  303 TPEDIASVDVLKDAsSSAVYGAKAANGVIAITTKK 337
Cdd:cd01347    75 PPELIERVEVLKGP-SSALYGSGAIGGVVNIITKR 108
PRK13486 PRK13486
TonB-dependent receptor;
198-337 9.12e-05

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 46.55  E-value: 9.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  198 SNFSIKLKEDTEVldeVVVVGYgtakKKDLTGAVSSVKA---EKLSAQAPRNVQDILRSnAAGLNIGIATDAKAEADLSV 274
Cdd:PRK13486   17 SASSIAAAEDVMI---VSASGY----EKKLTNAAASVSVisqEELQSSQYHDLAEALRS-VEGVDVESGTGKTGGLEISI 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491853669  275 RGKgtlsAGSSPLIVLDGViYEGNLSDITPEDIAS--------------VDVLKdASSSAVYGAKAANGVIAITTKK 337
Cdd:PRK13486   89 RGM----PASYTLILIDGV-RQGGSSDVTPNGFSAmntgfmpplaaierIEVIR-GPMSTLYGSDAMGGVVNIITRK 159
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 207-337 3.60e-04

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 44.88  E-value: 3.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  207 DTEVLDEVVVVGYGTAKK-KDLTGAVSSVKAEKLSAQAPRNVQDILRSNAAGLNIGIATDAKAeadLSVRGKGTlsagSS 285
Cdd:PRK10064   26 VDDDGETMVVTASAVEQNlKDAPASISVITQEDLQRKPVQNLKDVLKEVPGVQLTNEGDNRKG---VSIRGLDS----SY 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491853669  286 PLIVLDG-------VIYEGNLSD---ITPEDIASVDVLKDASSSaVYGAKAANGVIAITTKK 337
Cdd:PRK10064   99 TLILIDGkrvnsrnAVFRHNDFDlnwIPVDAIERIEVVRGPMSS-LYGSDALGGVVNIITKK 159
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 226-338 4.19e-04

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 44.33  E-value: 4.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   226 DLTGAVSSVKAEKLSAQAPRNVQDILRsNAAGLNIGIATDAKAEADLSVRGKGtlSAGSSPLIVLDGVI--YEGNLSDIT 303
Cdd:TIGR01783    1 DIPQSVSVITRQELEDQQAGSLSEALQ-RVPGVVVGGSGGTTQFGNITIRGFG--LEVDIDNVYLDGVPllSRGNLAIVD 77

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 491853669   304 PEDIASVDVLKDASSsAVYGAKAANGVIAITTKKG 338
Cdd:TIGR01783   78 PAMVERVEVLRGPAS-LLYGGSAPGGVINIVTKRP 111
OMP_b-brl_3 pfam14905
Outer membrane protein beta-barrel family; This family includes proteins annotated as TonB ...
 743-929 1.18e-03

Outer membrane protein beta-barrel family; This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.


Pssm-ID: 434300 [Multi-domain]  Cd Length: 407  Bit Score: 42.65  E-value: 1.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   743 FPSVALGWVFTQEQFMQqanswLNYAKLRIswgenGNR-DIGQyaalaqmkssLRPYIDQTgNIYTISQmfvntmANHNL 821
Cdd:pfam14905  160 FPSASLSYKLNDNNSLQ-----LSLYYRRI-----INRpSYWD----------LNPFRNYS-DPYNYSQ------GNPNL 212

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669   822 KWERTAAFNFGldFSLFDELlsgSIETYVSKTNDLLVKRALPDVTGFNSVT--ANLGQLQNKGFELTLNANIinSKDFKW 899
Cdd:pfam14905  213 KPEYTNSFELG--YTYKWKL---SLSLSYRYTNDVIQQTFITDDNDNVTYTtyENLGKSNSYGLELSASFNP--TKWWSL 285

                          170       180       190
                   ....*....|....*....|....*....|
gi 491853669   900 FASGNFSLNRRKINSLYGDMVDVLDENGNV 929
Cdd:pfam14905  286 NGNLNGYYNKYKIDGSLNSDFSNFGFNWNL 315
PRK13513 PRK13513
ligand-gated channel protein;
192-337 8.44e-03

ligand-gated channel protein;


Pssm-ID: 184104 [Multi-domain]  Cd Length: 659  Bit Score: 40.14  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  192 IIVANKSNFSIKLKEDTEVLDEVVVVgygTA-----KKKDLTGAVSSVKAEKLSAQAPRNVQDILRsNAAGLnigIATDA 266
Cdd:PRK13513   15 IAAAISSQAYAAEKTNTATPTDTMVV---TAsgfqqRIQDAPASISVVTREQLENKAYRDVTDALK-DVPGV---VVTGG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491853669  267 KAEADLSVRGKgtlsAGSSPLIVLDGV---------------IYEGNLSDItpEDIASVDVLKDASSSaVYGAKAANGVI 331
Cdd:PRK13513   88 GSTSDISIRGM----AAKYTLILVDGKrvdtrstrpnsdgsgIEQGWLPPL--AAIERIEVVRGPMSS-LYGSDAMGGVI 160


                  ....*.
gi 491853669  332 AITTKK 337
Cdd:PRK13513  161 NIITRK 166
STN smart00965
Secretin and TonB N terminus short domain; This is a short domain found at the N-terminus of ...
 72-120 9.55e-03

Secretin and TonB N terminus short domain; This is a short domain found at the N-terminus of the Secretins of the bacterial type II/III secretory system as well as the TonB-dependent receptor proteins. These proteins are involved in TonB-dependent active uptake of selective substrates.


Pssm-ID: 198033 [Multi-domain]  Cd Length: 52  Bit Score: 35.56  E-value: 9.55e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 491853669     72 YLVVFRDQDVdVNKTVSFNTKTATVADYLEMITKNTGISYQF-ENNYITL 120
Cdd:smart00965    1 LNFVYDPALV-AGRRVSLLLGNVTVEQALDRLLAGTGLTYRRiGGNTIVL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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