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Conserved domains on  [gi|491873760|ref|WP_005645618|]
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PepSY-like domain-containing protein [Parabacteroides merdae]

Protein Classification

PepSY-like domain-containing protein( domain architecture ID 11189192)

PepSY domain-containing protein may act as a regulator of peptidase activity and may also function in protecting the cell from lysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PepSY_like pfam11396
Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is ...
 57-147 4.76e-17

Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is probably periplasmic. Members are found predominantly in microbes of the human gut and oral cavity. Structurally, one member of this family is found to show similarity to the beta-lactamase-inhibitor PepSY proteins, so the overall function may be inhibitory. There are tandem repeats of the domain on many family members.


:

Pssm-ID: 431867  Cd Length: 83  Bit Score: 74.23  E-value: 4.76e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491873760   57 YLIVDFKQDKvekEAWFDNSGTWYMTE---TDIPFAQLPDAVKTAFQQGEYSTwkvDDVDMIERRDveTVYVIETEQgns 133
Cdd:pfam11396   1 YYDVDFTDGT---EVEFDKKGNWKETEckyTDVPLDILPAAVAKYFKASNYPD---EDVVKIERPK--TGYEIELEN--- 69

                          90
                  ....*....|....
gi 491873760  134 EVDLYYSPDGILVK 147
Cdd:pfam11396  70 GVELYFDPKGNLLK 83
PepSY_like super family cl24241
Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is ...
 194-280 8.84e-06

Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is probably periplasmic. Members are found predominantly in microbes of the human gut and oral cavity. Structurally, one member of this family is found to show similarity to the beta-lactamase-inhibitor PepSY proteins, so the overall function may be inhibitory. There are tandem repeats of the domain on many family members.


The actual alignment was detected with superfamily member pfam11396:

Pssm-ID: 431867  Cd Length: 83  Bit Score: 43.03  E-value: 8.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491873760  194 EVEILDGTvcrELLFDDGGAWMQTK---TELRITALPDAVMAAIKASQYATyriDDADFIE-TLTGewYLVELEsgkQEV 269
Cdd:pfam11396   3 DVDFTDGT---EVEFDKKGNWKETEckyTDVPLDILPAAVAKYFKASNYPD---EDVVKIErPKTG--YEIELE---NGV 71

                          90
                  ....*....|.
gi 491873760  270 KLRIDATGKIL 280
Cdd:pfam11396  72 ELYFDPKGNLL 82
 
Name Accession Description Interval E-value
PepSY_like pfam11396
Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is ...
 57-147 4.76e-17

Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is probably periplasmic. Members are found predominantly in microbes of the human gut and oral cavity. Structurally, one member of this family is found to show similarity to the beta-lactamase-inhibitor PepSY proteins, so the overall function may be inhibitory. There are tandem repeats of the domain on many family members.


Pssm-ID: 431867  Cd Length: 83  Bit Score: 74.23  E-value: 4.76e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491873760   57 YLIVDFKQDKvekEAWFDNSGTWYMTE---TDIPFAQLPDAVKTAFQQGEYSTwkvDDVDMIERRDveTVYVIETEQgns 133
Cdd:pfam11396   1 YYDVDFTDGT---EVEFDKKGNWKETEckyTDVPLDILPAAVAKYFKASNYPD---EDVVKIERPK--TGYEIELEN--- 69

                          90
                  ....*....|....
gi 491873760  134 EVDLYYSPDGILVK 147
Cdd:pfam11396  70 GVELYFDPKGNLLK 83
PepSY_like pfam11396
Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is ...
 194-280 8.84e-06

Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is probably periplasmic. Members are found predominantly in microbes of the human gut and oral cavity. Structurally, one member of this family is found to show similarity to the beta-lactamase-inhibitor PepSY proteins, so the overall function may be inhibitory. There are tandem repeats of the domain on many family members.


Pssm-ID: 431867  Cd Length: 83  Bit Score: 43.03  E-value: 8.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491873760  194 EVEILDGTvcrELLFDDGGAWMQTK---TELRITALPDAVMAAIKASQYATyriDDADFIE-TLTGewYLVELEsgkQEV 269
Cdd:pfam11396   3 DVDFTDGT---EVEFDKKGNWKETEckyTDVPLDILPAAVAKYFKASNYPD---EDVVKIErPKTG--YEIELE---NGV 71

                          90
                  ....*....|.
gi 491873760  270 KLRIDATGKIL 280
Cdd:pfam11396  72 ELYFDPKGNLL 82
 
Name Accession Description Interval E-value
PepSY_like pfam11396
Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is ...
 57-147 4.76e-17

Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is probably periplasmic. Members are found predominantly in microbes of the human gut and oral cavity. Structurally, one member of this family is found to show similarity to the beta-lactamase-inhibitor PepSY proteins, so the overall function may be inhibitory. There are tandem repeats of the domain on many family members.


Pssm-ID: 431867  Cd Length: 83  Bit Score: 74.23  E-value: 4.76e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491873760   57 YLIVDFKQDKvekEAWFDNSGTWYMTE---TDIPFAQLPDAVKTAFQQGEYSTwkvDDVDMIERRDveTVYVIETEQgns 133
Cdd:pfam11396   1 YYDVDFTDGT---EVEFDKKGNWKETEckyTDVPLDILPAAVAKYFKASNYPD---EDVVKIERPK--TGYEIELEN--- 69

                          90
                  ....*....|....
gi 491873760  134 EVDLYYSPDGILVK 147
Cdd:pfam11396  70 GVELYFDPKGNLLK 83
PepSY_like pfam11396
Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is ...
 194-280 8.84e-06

Putative beta-lactamase-inhibitor-like, PepSY-like; This family of bacterial proteins is probably periplasmic. Members are found predominantly in microbes of the human gut and oral cavity. Structurally, one member of this family is found to show similarity to the beta-lactamase-inhibitor PepSY proteins, so the overall function may be inhibitory. There are tandem repeats of the domain on many family members.


Pssm-ID: 431867  Cd Length: 83  Bit Score: 43.03  E-value: 8.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491873760  194 EVEILDGTvcrELLFDDGGAWMQTK---TELRITALPDAVMAAIKASQYATyriDDADFIE-TLTGewYLVELEsgkQEV 269
Cdd:pfam11396   3 DVDFTDGT---EVEFDKKGNWKETEckyTDVPLDILPAAVAKYFKASNYPD---EDVVKIErPKTG--YEIELE---NGV 71

                          90
                  ....*....|.
gi 491873760  270 KLRIDATGKIL 280
Cdd:pfam11396  72 ELYFDPKGNLL 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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