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Conserved domains on  [gi|491930720|ref|WP_005677823|]
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MULTISPECIES: efflux RND transporter permease subunit [Bacteroides]

Protein Classification

efflux RND transporter permease subunit( domain architecture ID 11436314)

efflux RND transporter permease subunit similar to Bacillus subtilis swarming motility protein SwrC, which is required for self-resistance to surfactin, an antimicrobial lipopeptide surfactant produced by B. subtilis

PubMed:  19026770|10941792
TCDB:  2.A.6

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
3-1029 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


:

Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 839.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    3 NIVKFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESmAIRQ-SDVTQV 81
Cdd:COG0841     2 NLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEE-ALNGvEGIKYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   82 SSVIKAGTARITVEYTWTKDMDEAFLDLQKAMNPFAQN--KEITELKITQHDANLSPVVLVGMSHQNItDMAELRRIAES 159
Cdd:COG0841    81 TSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDlpEDVEPPGVTKVNPSDFPVMVLALSSDDL-DELELSDYAER 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  160 YIRNELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQYLVKSSSLFSTEAD 239
Cdd:COG0841   160 NIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  240 FENLIVGYKpvqqetsgnsssetvtdlNKAPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVDEVTS 319
Cdd:COG0841   240 FENIVIRTN------------------DGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRA 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  320 RLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGL 398
Cdd:COG0841   302 KLEELQASLPeGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGF 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  399 TLNIMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFKD 478
Cdd:COG0841   382 SLNILTLFALVLAIGIVVDDAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQ 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  479 QAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEEVKSIRIT---------RYSKILRKLVRHRWWVIGMAVLLLVVTG 549
Cdd:COG0841   462 FALTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRFFRAFnrgfdrltrGYGRLLRWALRHRKLTLLVALALLALSV 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  550 LLTPFIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTIVGGDSlctIYSHVGEGSGSEnaifeGENTAMM 629
Cdd:COG0841   542 LLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVES---VFSVVGFSGGGS-----GSNSGTI 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  630 KIIL--FPECILSPENVIARFLEEAKNPDGLELSIRQdensLSSLLGSEGAPIVVEVKGEELDEIAKITGEVKERMQEVD 707
Cdd:COG0841   614 FVTLkpWDERDRSADEIIARLREKLAKIPGARVFVFQ----PPAGGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIP 689
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  708 GVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEYRGEMRDIVIKVPD---ISLGALGSLVI 784
Cdd:COG0841   690 GLVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEedrNSPEDLENLYV 769
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  785 RSGT-QEFLLDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDIDLPANYSITVTGEEEKRQES 863
Cdd:COG0841   770 RTPDgEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQES 849
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  864 MHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRI 943
Cdd:COG0841   850 FSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFA 929
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  944 NQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIPCVYYVLE 1023
Cdd:COG0841   930 NQLREEGMSLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLD 1009

                  ....*.
gi 491930720 1024 KIKRRI 1029
Cdd:COG0841  1010 RLRRRL 1015
 
Name Accession Description Interval E-value
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
3-1029 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 839.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    3 NIVKFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESmAIRQ-SDVTQV 81
Cdd:COG0841     2 NLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEE-ALNGvEGIKYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   82 SSVIKAGTARITVEYTWTKDMDEAFLDLQKAMNPFAQN--KEITELKITQHDANLSPVVLVGMSHQNItDMAELRRIAES 159
Cdd:COG0841    81 TSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDlpEDVEPPGVTKVNPSDFPVMVLALSSDDL-DELELSDYAER 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  160 YIRNELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQYLVKSSSLFSTEAD 239
Cdd:COG0841   160 NIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  240 FENLIVGYKpvqqetsgnsssetvtdlNKAPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVDEVTS 319
Cdd:COG0841   240 FENIVIRTN------------------DGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRA 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  320 RLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGL 398
Cdd:COG0841   302 KLEELQASLPeGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGF 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  399 TLNIMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFKD 478
Cdd:COG0841   382 SLNILTLFALVLAIGIVVDDAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQ 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  479 QAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEEVKSIRIT---------RYSKILRKLVRHRWWVIGMAVLLLVVTG 549
Cdd:COG0841   462 FALTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRFFRAFnrgfdrltrGYGRLLRWALRHRKLTLLVALALLALSV 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  550 LLTPFIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTIVGGDSlctIYSHVGEGSGSEnaifeGENTAMM 629
Cdd:COG0841   542 LLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVES---VFSVVGFSGGGS-----GSNSGTI 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  630 KIIL--FPECILSPENVIARFLEEAKNPDGLELSIRQdensLSSLLGSEGAPIVVEVKGEELDEIAKITGEVKERMQEVD 707
Cdd:COG0841   614 FVTLkpWDERDRSADEIIARLREKLAKIPGARVFVFQ----PPAGGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIP 689
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  708 GVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEYRGEMRDIVIKVPD---ISLGALGSLVI 784
Cdd:COG0841   690 GLVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEedrNSPEDLENLYV 769
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  785 RSGT-QEFLLDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDIDLPANYSITVTGEEEKRQES 863
Cdd:COG0841   770 RTPDgEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQES 849
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  864 MHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRI 943
Cdd:COG0841   850 FSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFA 929
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  944 NQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIPCVYYVLE 1023
Cdd:COG0841   930 NQLREEGMSLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLD 1009

                  ....*.
gi 491930720 1024 KIKRRI 1029
Cdd:COG0841  1010 RLRRRL 1015
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
4-1023 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 595.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720     4 IVKFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESMAIRQSDVTQVSS 83
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    84 VIKAGTARITVEYTWTKDMDEAFLDLQKAMNPfAQNK---EITELKITQHDANLSPVVLVGM-SHQNITDMAELRRIAES 159
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQL-ATPLlpeGVQRPGISVIKTSLGPIMVLAVtSPDGSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   160 YIRNELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQYLVKSSSLFSTEAD 239
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAED 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   240 FENLIVGYKpvqqetsgnsssetvtdlNKAPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVDEVTS 319
Cdd:pfam00873  240 FEKIIVKNQ------------------DGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRA 301
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   320 RLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGL 398
Cdd:pfam00873  302 KLAELKPTFPqGVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGF 381
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   399 TLNIMTLGGLALGAGMLVDNAIVVIESIFRN-QEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFK 477
Cdd:pfam00873  382 SINTLTLGGLVLAIGLVVDDAIVVVENIERVlEENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFR 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   478 DQAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEEVKSIR---------ITRYSKILRKLVRHRWWVIGMAVLLLVVT 548
Cdd:pfam00873  462 QFAITIVLAILLSVLVALTLTPALCATLLKPRREPKHGGFFRwfnrmfdrlTRGYAKLLAKVLRHTAVVLLVALLLVVGS 541
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   549 GLLTPFIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTIVGGDSLctiyshVGEGSGSENAIFEGENTAM 628
Cdd:pfam00873  542 VWLFVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESV------FAVTGFAFSGDNNGPNSGD 615
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   629 MKIILFPE-----CILSPENVIARFLEEAKNPDGLELSIrQDENSLSSLLGSEG--APIVVEVKGEELDEIAKITGEVKE 701
Cdd:pfam00873  616 AFISLKPWkerpgPEKSVQALIERLRKALKQIPGANVFL-FQPIQLRGLGTISGfrSDLQVKIFGDDLDALDEARNQILA 694
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   702 RMQEVDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEYRGEMRDIVIKVPD---ISLGA 778
Cdd:pfam00873  695 ALAQLPGLSDVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEdfrSSPED 774
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   779 LGSLVIRSGTQEFL-LDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDIDLPANYSITVTGEE 857
Cdd:pfam00873  775 IGQLYVRNPYGKMIpLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQF 854
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   858 EKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSI 937
Cdd:pfam00873  855 EQEQLAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAI 934
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   938 ILVDRINQL-SQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIP 1016
Cdd:pfam00873  935 LMVEFANELrEQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVP 1014

                   ....*..
gi 491930720  1017 CVYYVLE 1023
Cdd:pfam00873 1015 VFYVLFH 1021
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
12-1024 1.94e-151

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 476.43  E-value: 1.94e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   12 PVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESMAIRQSDVTQVSSVIKAGTAR 91
Cdd:NF033617    8 PVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYST 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   92 ITVEYTWTKDMDEAFLDLQKAMNPfAQNKEITELK--ITQHDANLS--PVVLVG-----MSHQNITDMAELRriaesyIR 162
Cdd:NF033617   88 ITLQFRLGTDLDVALSEVQAAINA-AQSLLPSEAPdpPVYRKANSAdtPIMYIGltseeMPRGQLTDYAERV------LA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  163 NELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQYLVKSSSLFSTEADFEN 242
Cdd:NF033617  161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  243 LIVGYKPvqqetsgnsssetvtdlNKAPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVDEVTSRLA 322
Cdd:NF033617  241 LVIKYAD-----------------NGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLP 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  323 VIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGLTLN 401
Cdd:NF033617  304 ELQETLPkNIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSIN 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  402 IMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFKDQAW 481
Cdd:NF033617  384 LLTLMALVLAIGLVVDDAIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAV 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  482 TVTFSLVSSLFVAILVIPMLYTQLSGKKVK-------MEEVKSIRITRYSKILRKLVRHRWWVIGMAVLLLVVTGLLTPF 554
Cdd:NF033617  464 TLAGAVIISGIVALTLTPMMCSRLLKANEKpgrfaraVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVF 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  555 IGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTIVGGDSLcTIYSHVGEGSGSenaifegeNTAMMKIILF 634
Cdd:NF033617  544 IPKELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSL-TSFNGVGGNPGD--------NTGFGIINLK 614
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  635 P--ECILSPENVIARFLEEAKNPDGLELSIRQdensLSSLLGSEG---APIVVEVKGEELDEIAKITGEVKERMQEVDGV 709
Cdd:NF033617  615 PwdERDVSAQEIIDRLRPKLAKVPGMDLFLFP----LQDLPGGAGsslPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQF 690
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  710 YDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEYRGEMRDIVIKV---PDISLGALGSLVIRS 786
Cdd:NF033617  691 ADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVdrrYRLNPEALNQIYVRS 770
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  787 GTQEFL-LDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDIdLPANYSITVTGEEEKRQESMH 865
Cdd:NF033617  771 NDGKLVpLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGISGSFQGAARAFQEEGS 849
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  866 SLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRINQ 945
Cdd:NF033617  850 SLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANE 929
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  946 LS-QAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIPCVYYVLEK 1024
Cdd:NF033617  930 LQrHQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
4-1021 8.22e-114

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 376.79  E-value: 8.22e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720     4 IVKFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQF-------------VKNMES 70
Cdd:TIGR00914    5 IISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVtypietamaglpgLETTRS 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    71 MAirQSDVTQVSSVIKAGT----ARITVEYTWTKDMDEAFLDLQKAMNPFAQN-KEITELKITQHDAnlspvvlVGMSHQ 145
Cdd:TIGR00914   85 LS--RYGLSQVTVIFKDGTdlyfARQLVNERLQQARDNLPEGVSPEMGPISTGlGEIFLYTVEAEEG-------ARKKDG 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   146 NITDMAELRRIAESYIRNELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQ 225
Cdd:TIGR00914  156 GAYTLTDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQ 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   226 YLVKSSSLFSTEADFENLIVGykpvqqetsgnsSSETVtdlnkaPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKE 305
Cdd:TIGR00914  236 YLVRAPGQVQSMDDIRNIVIA------------TGEGV------PIRIRDVARVQIGKELRTGAATENGKEVVLGTVFML 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   306 MRFNTVKVVDEVTSRLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPI 384
Cdd:TIGR00914  298 IGENSRTVAQAVGDKLETINKTLPeGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPL 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   385 SIVATFNLMFFNGLTLNIMTLGGLALGAgmLVDNAIVVIESIFRNQE-------KGVSVKE---AVVTGTAEVANAVIAS 454
Cdd:TIGR00914  378 SLLITFIGMVFQGISANLMSLGALDFGL--IVDGAVVIVENAHRRLAeaqhhhgRQLTLKErlhEVFAASREVRRPLIFG 455
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   455 TLTTIVVFLPIVYLHGASGELFKDQAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEEVKSIRIT--RYSKILRKLVR 532
Cdd:TIGR00914  456 QLIITLVFLPIFTLTGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVAEKENRLMRVLkrRYEPLLERVLA 535
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   533 HRWWVIGMAVLLLVVTGLLTPFIGTEFMPR-AESKAFTAVVKMPeGTQMERTAAAVGNLEDLLYTIvggDSLCTIYSHVG 611
Cdd:TIGR00914  536 WPAVVLGAAAVSIVLVVWIASRVGGEFIPSlNEGDLAYQALRIP-GTSLAQSVAMQQTLEKLIKSF---PEVARVFAKTG 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   612 EGSGSENAIfeGENTAMMKIIL-----FPECILSPENVIARFLEEAKNPDGLELSIRQD-ENSLSSLLGSEGAPIVVEVK 685
Cdd:TIGR00914  612 TAEIATDPM--PPNASDTYIILkpesqWPEGKKTKEDLIEEIQEATVRIPGNNYEFTQPiQMRFNELISGVRSDVAVKVF 689
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   686 GEELDEIAKITGEVKERMQEVDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMeYRGEMR 765
Cdd:TIGR00914  690 GDDLDDLDATAEKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGET-FEGDRR 768
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   766 -DIVIKVPDI---SLGALGSLVI-----RSGTQEFL-LDEIASITHGQAPKEILRRNQSRIGKIMANM---DTGKSLDKV 832
Cdd:TIGR00914  769 fDIVIRLPESlreSPQALRQLPIplplsEDARKQFIpLSDVADLRVSPGPNQISRENGKRRVVVSANVrgrDLGSFVDDA 848
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   833 AAEVRLAVKdidLPANYSITVTGEEEKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFI 912
Cdd:TIGR00914  849 KKAIAEQVK---LPPGYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWL 925
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   913 TGTTINMMGVIGIVMLGGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASL 992
Cdd:TIGR00914  926 RGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLLEEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEV 1005
                         1050      1060
                   ....*....|....*....|....*....
gi 491930720   993 RSPMAIAVIGGLITSTLMSLMVIPCVYYV 1021
Cdd:TIGR00914 1006 QRPLATVVIGGIITATLLTLFVLPALYRL 1034
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
12-1036 1.70e-93

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 320.52  E-value: 1.70e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   12 PVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESMAIRQSDVTQVSSVIKAGTAR 91
Cdd:PRK10614   11 PVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTR 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   92 ITVEYTWTKDMDEAFLDLQKAMNPfAQNKEITEL--KITQHDANLS--PVVLVGMSHQNITDmAELRRIAESYIRNELIR 167
Cdd:PRK10614   91 IILQFDFDRDINGAARDVQAAINA-AQSLLPSGMpsRPTYRKANPSdaPIMILTLTSDTYSQ-GQLYDFASTQLAQTISQ 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  168 LEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQYLVKSSSLFSTEADFENLIVGY 247
Cdd:PRK10614  169 IDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLIIHY 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  248 KpvqqetsgnsssetvtdlNKAPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVDEVTSRLAVIEDA 327
Cdd:PRK10614  249 N------------------NGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRET 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  328 LP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGLTLNIMTLG 406
Cdd:PRK10614  311 IPaAIDLQIAQDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLM 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  407 GLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFKDQAWTVTFS 486
Cdd:PRK10614  391 ALTIATGFVVDDAIVVLENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVA 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  487 LVSSLFVAILVIPMLYTQLSgKKVKMEEVKSIR-ITR--------YSKILRKLVRHRWWVIGMAVLLLVVTGLLTPFIGT 557
Cdd:PRK10614  471 IGISLLVSLTLTPMMCAWLL-KSSKPREQKRLRgFGRmlvalqqgYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPK 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  558 EFMPRAESKAFTAVVKMPEGTQMErtaAAVGNLEDLLyTIVGGDSlcTIYSHVGEGSGSENaifegeNTAMMKIILFP-- 635
Cdd:PRK10614  550 TFFPEQDTGRLMGFIQADQSISFQ---AMRGKLQDFM-KIIRDDP--AVDNVTGFTGGSRV------NSGMMFITLKPls 617
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  636 ECILSPENVIARFLEEAKNPDGLELSI----------RQDENSLSSLLGSegapivvevkgEELDEIAKITGEVKERMQE 705
Cdd:PRK10614  618 ERSETAQQVIDRLRVKLAKEPGANLFLmavqdirvggRQSNASYQYTLLS-----------DDLAALREWEPKIRKALAA 686
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  706 VDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQL-----KQQLSGKEAGKMEYRGEMRDIVIKVPDISlgALG 780
Cdd:PRK10614  687 LPELADVNSDQQDKGAEMALTYDRDTMARLGIDVQAANSLLnnafgQRQISTIYQPLNQYKVVMEVDPRYTQDIS--ALE 764
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  781 SL-VIRSGTQEFLLDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDIDLPANYSITVTGEEEK 859
Cdd:PRK10614  765 KMfVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIERAMTQLGVPSTVRGSFAGTAQV 844
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  860 RQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIIL 939
Cdd:PRK10614  845 FQETMNSQLILILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMM 924
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  940 VD-RINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIPCV 1018
Cdd:PRK10614  925 VDfALEAQRNGNLTAQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVV 1004
                        1050
                  ....*....|....*...
gi 491930720 1019 YYVLEKIKRRINHRTKKS 1036
Cdd:PRK10614 1005 YLFFDRLRLRFSRKPKQT 1022
 
Name Accession Description Interval E-value
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
3-1029 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 839.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    3 NIVKFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESmAIRQ-SDVTQV 81
Cdd:COG0841     2 NLSRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEE-ALNGvEGIKYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   82 SSVIKAGTARITVEYTWTKDMDEAFLDLQKAMNPFAQN--KEITELKITQHDANLSPVVLVGMSHQNItDMAELRRIAES 159
Cdd:COG0841    81 TSTSSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDlpEDVEPPGVTKVNPSDFPVMVLALSSDDL-DELELSDYAER 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  160 YIRNELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQYLVKSSSLFSTEAD 239
Cdd:COG0841   160 NIKDRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEE 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  240 FENLIVGYKpvqqetsgnsssetvtdlNKAPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVDEVTS 319
Cdd:COG0841   240 FENIVIRTN------------------DGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRA 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  320 RLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGL 398
Cdd:COG0841   302 KLEELQASLPeGVELTIVYDQSEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGF 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  399 TLNIMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFKD 478
Cdd:COG0841   382 SLNILTLFALVLAIGIVVDDAIVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQ 461
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  479 QAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEEVKSIRIT---------RYSKILRKLVRHRWWVIGMAVLLLVVTG 549
Cdd:COG0841   462 FALTVAIALLISLFVALTLTPALCARLLKPHPKGKKGRFFRAFnrgfdrltrGYGRLLRWALRHRKLTLLVALALLALSV 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  550 LLTPFIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTIVGGDSlctIYSHVGEGSGSEnaifeGENTAMM 629
Cdd:COG0841   542 LLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVES---VFSVVGFSGGGS-----GSNSGTI 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  630 KIIL--FPECILSPENVIARFLEEAKNPDGLELSIRQdensLSSLLGSEGAPIVVEVKGEELDEIAKITGEVKERMQEVD 707
Cdd:COG0841   614 FVTLkpWDERDRSADEIIARLREKLAKIPGARVFVFQ----PPAGGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIP 689
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  708 GVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEYRGEMRDIVIKVPD---ISLGALGSLVI 784
Cdd:COG0841   690 GLVDVRSDLQLGKPELQLDIDREKAAALGVTVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEedrNSPEDLENLYV 769
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  785 RSGT-QEFLLDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDIDLPANYSITVTGEEEKRQES 863
Cdd:COG0841   770 RTPDgEMVPLSSVATIEEGTGPSSINRYNGQRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQES 849
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  864 MHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRI 943
Cdd:COG0841   850 FSSLGLAFLLALLLVYLVLAAQFESFIQPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFA 929
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  944 NQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIPCVYYVLE 1023
Cdd:COG0841   930 NQLREEGMSLREAILEAARLRLRPILMTSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLD 1009

                  ....*.
gi 491930720 1024 KIKRRI 1029
Cdd:COG0841  1010 RLRRRL 1015
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
4-1023 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 595.81  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720     4 IVKFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESMAIRQSDVTQVSS 83
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    84 VIKAGTARITVEYTWTKDMDEAFLDLQKAMNPfAQNK---EITELKITQHDANLSPVVLVGM-SHQNITDMAELRRIAES 159
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQL-ATPLlpeGVQRPGISVIKTSLGPIMVLAVtSPDGSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   160 YIRNELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQYLVKSSSLFSTEAD 239
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAED 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   240 FENLIVGYKpvqqetsgnsssetvtdlNKAPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVDEVTS 319
Cdd:pfam00873  240 FEKIIVKNQ------------------DGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRA 301
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   320 RLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGL 398
Cdd:pfam00873  302 KLAELKPTFPqGVEIVVVYDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGF 381
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   399 TLNIMTLGGLALGAGMLVDNAIVVIESIFRN-QEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFK 477
Cdd:pfam00873  382 SINTLTLGGLVLAIGLVVDDAIVVVENIERVlEENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFR 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   478 DQAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEEVKSIR---------ITRYSKILRKLVRHRWWVIGMAVLLLVVT 548
Cdd:pfam00873  462 QFAITIVLAILLSVLVALTLTPALCATLLKPRREPKHGGFFRwfnrmfdrlTRGYAKLLAKVLRHTAVVLLVALLLVVGS 541
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   549 GLLTPFIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTIVGGDSLctiyshVGEGSGSENAIFEGENTAM 628
Cdd:pfam00873  542 VWLFVRIPTEFLPEEDEGVFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESV------FAVTGFAFSGDNNGPNSGD 615
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   629 MKIILFPE-----CILSPENVIARFLEEAKNPDGLELSIrQDENSLSSLLGSEG--APIVVEVKGEELDEIAKITGEVKE 701
Cdd:pfam00873  616 AFISLKPWkerpgPEKSVQALIERLRKALKQIPGANVFL-FQPIQLRGLGTISGfrSDLQVKIFGDDLDALDEARNQILA 694
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   702 RMQEVDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEYRGEMRDIVIKVPD---ISLGA 778
Cdd:pfam00873  695 ALAQLPGLSDVRSDGQEDQPQLQVNIDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEdfrSSPED 774
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   779 LGSLVIRSGTQEFL-LDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDIDLPANYSITVTGEE 857
Cdd:pfam00873  775 IGQLYVRNPYGKMIpLSAFAKIEWGYGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQF 854
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   858 EKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSI 937
Cdd:pfam00873  855 EQEQLAGNSLPILIALALLVVFLVLAALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAI 934
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   938 ILVDRINQL-SQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIP 1016
Cdd:pfam00873  935 LMVEFANELrEQEGKSLEEAILEACRLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVP 1014

                   ....*..
gi 491930720  1017 CVYYVLE 1023
Cdd:pfam00873 1015 VFYVLFH 1021
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
1-1028 3.57e-177

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 544.24  E-value: 3.57e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    1 MKNIVKFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQfV-----KNMESMAirq 75
Cdd:COG3696     2 LNRIIRFSLRNRLLVLLLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQ-VtypieTALNGLP--- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   76 sDVTQVSSVIKAGTARITVEYTWTKDMDeafldlqkamnpFAQNkEITElKITQHDANLSPVVLVGM------------- 142
Cdd:COG3696    78 -GVKEVRSISRFGLSVVTVIFEDGTDIY------------WARQ-LVLE-RLQQVREQLPAGVTPELgpistglgeiyqy 142
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  143 ---SHQNITDMAELRRIAESYIRNELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRV 219
Cdd:COG3696   143 tleSDPGKYSLMELRTLQDWVIRPQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYI 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  220 SELGLQYLVKSSSLFSTEADFENLIVGYKpvqqetsgnsssetvtdlNKAPVFLKEVATVQFVNARPENIVRINGKR-SI 298
Cdd:COG3696   223 ERGGQEYLVRGIGLIRSLEDIENIVVKTR------------------NGTPVLLRDVAEVRIGPAPRRGAATLNGEGeVV 284
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  299 GLSIykEMRF--NTVKVVDEVTSRLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTT 375
Cdd:COG3696   285 GGIV--LMLKgeNALEVIEAVKAKLAELKPSLPeGVKIVPFYDRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAA 362
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  376 LIVSLSIPISIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFR------NQEKGVSVKEAVVTGTAEVAN 449
Cdd:COG3696   363 LIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGIIVDGAVVMVENILRrleenrAAGTPRERLEVVLEAAREVRR 442
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  450 AVIASTLTTIVVFLPIVYLHGASGELFKDQAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEEVKSIR--ITRYSKIL 527
Cdd:COG3696   443 PIFFATLIIILVFLPIFTLEGVEGKLFRPMALTVIFALLGALLLSLTLVPVLASLLLRGKVPEKENPLVRwlKRLYRPLL 522
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  528 RKLVRHRWWVIGMAVLLLVVTGLLTPFIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTI--VGgdslcT 605
Cdd:COG3696   523 RWALRHPKLVLAVALVLLVLALALFPRLGSEFLPELDEGDLLVMATLPPGISLEESVELGQQVERILKSFpeVE-----S 597
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  606 IYSHVGEG-SGSENA-IFEGENTAMMKiilfPE----CILSPENVIARFLEEAKNPDGLELSIRQ------DEnslssLL 673
Cdd:COG3696   598 VVSRTGRAeDATDPMgVNMSETFVILK----PRsewrSGRTKEELIAEMREALEQIPGVNFNFSQpiqmrvDE-----LL 668
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  674 GSEGAPIVVEVKGEELDEIAKITGEVKERMQEVDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGK 753
Cdd:COG3696   669 SGVRADVAVKIFGDDLDVLRRLAEQIEAVLKTVPGAADVQVERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGK 748
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  754 EAGKMeYRGEMR-DIVIKVPD---ISLGALGSLVIRSGTQEFL-LDEIASITHGQAPKEILRRNQSRIGKIMANMDtGKS 828
Cdd:COG3696   749 AVGQV-YEGERRfDIVVRLPEelrDDPEAIRNLPIPTPSGAQVpLSQVADIEVVEGPNQISRENGRRRIVVQANVR-GRD 826
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  829 LDKVAAEVRLAV-KDIDLPANYSITVTGEEEKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAI 907
Cdd:COG3696   827 LGSFVAEAQAKVaEQVKLPPGYYIEWGGQFENLQRATARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGV 906
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  908 LLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFG 987
Cdd:COG3696   907 LALWLRGMPLSVSAGVGFIALFGVAVLNGVVLVSYINQLRAEGLDLREAIIEGALERLRPVLMTALVAALGLLPMALSTG 986
                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|.
gi 491930720  988 EGASLRSPMAIAVIGGLITSTLMSLMVIPCVYYVLEKIKRR 1028
Cdd:COG3696   987 PGSEVQRPLATVVIGGLITSTLLTLLVLPALYLLFGRRRLR 1027
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
12-1024 1.94e-151

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 476.43  E-value: 1.94e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   12 PVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESMAIRQSDVTQVSSVIKAGTAR 91
Cdd:NF033617    8 PVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQSSLGYST 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   92 ITVEYTWTKDMDEAFLDLQKAMNPfAQNKEITELK--ITQHDANLS--PVVLVG-----MSHQNITDMAELRriaesyIR 162
Cdd:NF033617   88 ITLQFRLGTDLDVALSEVQAAINA-AQSLLPSEAPdpPVYRKANSAdtPIMYIGltseeMPRGQLTDYAERV------LA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  163 NELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQYLVKSSSLFSTEADFEN 242
Cdd:NF033617  161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  243 LIVGYKPvqqetsgnsssetvtdlNKAPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVDEVTSRLA 322
Cdd:NF033617  241 LVIKYAD-----------------NGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLP 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  323 VIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGLTLN 401
Cdd:NF033617  304 ELQETLPkNIKVNVLYDRTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSIN 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  402 IMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFKDQAW 481
Cdd:NF033617  384 LLTLMALVLAIGLVVDDAIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAV 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  482 TVTFSLVSSLFVAILVIPMLYTQLSGKKVK-------MEEVKSIRITRYSKILRKLVRHRWWVIGMAVLLLVVTGLLTPF 554
Cdd:NF033617  464 TLAGAVIISGIVALTLTPMMCSRLLKANEKpgrfaraVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVF 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  555 IGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTIVGGDSLcTIYSHVGEGSGSenaifegeNTAMMKIILF 634
Cdd:NF033617  544 IPKELAPSEDRGVIFGMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSL-TSFNGVGGNPGD--------NTGFGIINLK 614
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  635 P--ECILSPENVIARFLEEAKNPDGLELSIRQdensLSSLLGSEG---APIVVEVKGEELDEIAKITGEVKERMQEVDGV 709
Cdd:NF033617  615 PwdERDVSAQEIIDRLRPKLAKVPGMDLFLFP----LQDLPGGAGsslPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQF 690
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  710 YDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEYRGEMRDIVIKV---PDISLGALGSLVIRS 786
Cdd:NF033617  691 ADVDSDLQDKGPELNVDIDRDKAARLGISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVdrrYRLNPEALNQIYVRS 770
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  787 GTQEFL-LDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDIdLPANYSITVTGEEEKRQESMH 865
Cdd:NF033617  771 NDGKLVpLSTLAKIEERAAPLSLNHFNQFNSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGISGSFQGAARAFQEEGS 849
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  866 SLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRINQ 945
Cdd:NF033617  850 SLLFLFLLALAAIYLVLAIQYESFVDPLTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANE 929
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  946 LS-QAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIPCVYYVLEK 1024
Cdd:NF033617  930 LQrHQGLSRREAIYQAAALRLRPILMTTLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
4-1021 8.22e-114

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 376.79  E-value: 8.22e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720     4 IVKFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQF-------------VKNMES 70
Cdd:TIGR00914    5 IISFSVAQRWLVLLATLVMAILGIWSYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVtypietamaglpgLETTRS 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    71 MAirQSDVTQVSSVIKAGT----ARITVEYTWTKDMDEAFLDLQKAMNPFAQN-KEITELKITQHDAnlspvvlVGMSHQ 145
Cdd:TIGR00914   85 LS--RYGLSQVTVIFKDGTdlyfARQLVNERLQQARDNLPEGVSPEMGPISTGlGEIFLYTVEAEEG-------ARKKDG 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   146 NITDMAELRRIAESYIRNELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQ 225
Cdd:TIGR00914  156 GAYTLTDLRTIQDWIIRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQ 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   226 YLVKSSSLFSTEADFENLIVGykpvqqetsgnsSSETVtdlnkaPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKE 305
Cdd:TIGR00914  236 YLVRAPGQVQSMDDIRNIVIA------------TGEGV------PIRIRDVARVQIGKELRTGAATENGKEVVLGTVFML 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   306 MRFNTVKVVDEVTSRLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPI 384
Cdd:TIGR00914  298 IGENSRTVAQAVGDKLETINKTLPeGVEIVTTYDRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPL 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   385 SIVATFNLMFFNGLTLNIMTLGGLALGAgmLVDNAIVVIESIFRNQE-------KGVSVKE---AVVTGTAEVANAVIAS 454
Cdd:TIGR00914  378 SLLITFIGMVFQGISANLMSLGALDFGL--IVDGAVVIVENAHRRLAeaqhhhgRQLTLKErlhEVFAASREVRRPLIFG 455
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   455 TLTTIVVFLPIVYLHGASGELFKDQAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEEVKSIRIT--RYSKILRKLVR 532
Cdd:TIGR00914  456 QLIITLVFLPIFTLTGVEGKMFHPMAFTVVLALAGAMILSLTFVPAAVALFIRGKVAEKENRLMRVLkrRYEPLLERVLA 535
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   533 HRWWVIGMAVLLLVVTGLLTPFIGTEFMPR-AESKAFTAVVKMPeGTQMERTAAAVGNLEDLLYTIvggDSLCTIYSHVG 611
Cdd:TIGR00914  536 WPAVVLGAAAVSIVLVVWIASRVGGEFIPSlNEGDLAYQALRIP-GTSLAQSVAMQQTLEKLIKSF---PEVARVFAKTG 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   612 EGSGSENAIfeGENTAMMKIIL-----FPECILSPENVIARFLEEAKNPDGLELSIRQD-ENSLSSLLGSEGAPIVVEVK 685
Cdd:TIGR00914  612 TAEIATDPM--PPNASDTYIILkpesqWPEGKKTKEDLIEEIQEATVRIPGNNYEFTQPiQMRFNELISGVRSDVAVKVF 689
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   686 GEELDEIAKITGEVKERMQEVDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMeYRGEMR 765
Cdd:TIGR00914  690 GDDLDDLDATAEKISAVLKGVPGAADVKVEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGET-FEGDRR 768
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   766 -DIVIKVPDI---SLGALGSLVI-----RSGTQEFL-LDEIASITHGQAPKEILRRNQSRIGKIMANM---DTGKSLDKV 832
Cdd:TIGR00914  769 fDIVIRLPESlreSPQALRQLPIplplsEDARKQFIpLSDVADLRVSPGPNQISRENGKRRVVVSANVrgrDLGSFVDDA 848
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   833 AAEVRLAVKdidLPANYSITVTGEEEKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFI 912
Cdd:TIGR00914  849 KKAIAEQVK---LPPGYWITWGGQFEQLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWL 925
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   913 TGTTINMMGVIGIVMLGGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASL 992
Cdd:TIGR00914  926 RGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLLEEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEV 1005
                         1050      1060
                   ....*....|....*....|....*....
gi 491930720   993 RSPMAIAVIGGLITSTLMSLMVIPCVYYV 1021
Cdd:TIGR00914 1006 QRPLATVVIGGIITATLLTLFVLPALYRL 1034
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
4-1032 7.79e-97

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 330.15  E-value: 7.79e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720     4 IVKFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELK--------VGERPPEEIEKQF--VKNMESMAi 73
Cdd:TIGR00915    1 MAKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASypgasaqtVQDTVTQVIEQNMngIDGLRYMS- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    74 rqsdvtqvSSVIKAGTARITVEYTWTKDMDEAFLD----LQKAMNPFAQNKEITELKITQHDANLSPVVLVgMSHQNITD 149
Cdd:TIGR00915   80 --------SSSDSDGSMTITLTFEQGTDPDIAQVQvqnkLQLATPLLPQEVQRQGVRVEKASSNFLMVIGL-VSDDGSMT 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   150 MAELRRIAESYIRNELIRLEGVAEVTLSGEEVTtLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSEL------G 223
Cdd:TIGR00915  151 KEDLSDYAASNMVDPLSRLEGVGDVQLFGSQYA-MRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLGGLpavpgqQ 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   224 LQYLVKSSSLFSTEADFENLIVgykpvqqeTSGNSSSEtvtdlnkapVFLKEVATVQFVNARPENIVRINGKRSIGLSIY 303
Cdd:TIGR00915  230 LNATIIAQTRLQTPEQFENILL--------KVNTDGSQ---------VRLKDVARVELGGENYSISARFNGKPASGLAIK 292
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   304 KEMRFNTVKVVDEVTSRLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSI 382
Cdd:TIGR00915  293 LATGANALDTAKAVKAELAVLEPFFPqGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAV 372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   383 PISIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFR-NQEKGVSVKEAVVTGTAEVANAVIASTLTTIVV 461
Cdd:TIGR00915  373 PVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVDDAIVVVENVERvMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAV 452
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   462 FLPIVYLHGASGELFKDQAWTVTFSLVSSLFVAILVIPMLYTQL--SGKKVKMEEVKS-----------IRITRYSKILR 528
Cdd:TIGR00915  453 FVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMlkPIEKGEHHEKKGgffgwfnrmfdSSTHGYENGVG 532
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   529 KLVRHRWWVIGMAVLLLVVTGLLTPFIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTiVGGDSLCTIYS 608
Cdd:TIGR00915  533 KILRRRGRYLLVYVLLVGGMVFLFVRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLA-KEKANVESVFT 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   609 HVGEG-SGSenaifeGENTAMMKIILFP-ECILSPEN----VIAR-FLEEAKNPDGLELSIrqDENSLSSLLGSEGAPIV 681
Cdd:TIGR00915  612 VNGFSfAGR------GQNMGMAFIRLKDwEERTGKENsvfaIAGRaTGHFMQIKDAMVIAF--VPPAILELGNATGFDFF 683
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   682 VEVK-GEELDEIAKITGEVKERMQEVDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEY 760
Cdd:TIGR00915  684 LQDRaGLGHEALLQARNQLLGLAAQNPALTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFID 763
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   761 RGEMRDIVIKVPD---ISLGALGSLVIRSGTQEFL-LDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEV 836
Cdd:TIGR00915  764 RGRVKRVYVQAEEdarMSPEDINKWYVRNASGEMVpFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAM 843
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   837 RLAVKdiDLPANYSITVTGE--EEKRQESMHSLLFAllLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITG 914
Cdd:TIGR00915  844 EAIAQ--KLPPGFGFSWTGMsyEERLSGSQAPALYA--LSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRG 919
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   915 TTINMMGVIGIVMLGGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRS 994
Cdd:TIGR00915  920 LSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQH 999
                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 491930720   995 PMAIAVIGGLITSTLMSLMVIPCVYYVLEKIKRRINHR 1032
Cdd:TIGR00915 1000 AIGTGVFGGMVTATVLAIFFVPLFYVVVRRLFKRKAHE 1037
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
12-1036 1.70e-93

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 320.52  E-value: 1.70e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   12 PVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESMAIRQSDVTQVSSVIKAGTAR 91
Cdd:PRK10614   11 PVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSLGSTR 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   92 ITVEYTWTKDMDEAFLDLQKAMNPfAQNKEITEL--KITQHDANLS--PVVLVGMSHQNITDmAELRRIAESYIRNELIR 167
Cdd:PRK10614   91 IILQFDFDRDINGAARDVQAAINA-AQSLLPSGMpsRPTYRKANPSdaPIMILTLTSDTYSQ-GQLYDFASTQLAQTISQ 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  168 LEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQYLVKSSSLFSTEADFENLIVGY 247
Cdd:PRK10614  169 IDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLIIHY 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  248 KpvqqetsgnsssetvtdlNKAPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVDEVTSRLAVIEDA 327
Cdd:PRK10614  249 N------------------NGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRET 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  328 LP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGLTLNIMTLG 406
Cdd:PRK10614  311 IPaAIDLQIAQDRSPTIRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLM 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  407 GLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFKDQAWTVTFS 486
Cdd:PRK10614  391 ALTIATGFVVDDAIVVLENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVA 470
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  487 LVSSLFVAILVIPMLYTQLSgKKVKMEEVKSIR-ITR--------YSKILRKLVRHRWWVIGMAVLLLVVTGLLTPFIGT 557
Cdd:PRK10614  471 IGISLLVSLTLTPMMCAWLL-KSSKPREQKRLRgFGRmlvalqqgYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPK 549
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  558 EFMPRAESKAFTAVVKMPEGTQMErtaAAVGNLEDLLyTIVGGDSlcTIYSHVGEGSGSENaifegeNTAMMKIILFP-- 635
Cdd:PRK10614  550 TFFPEQDTGRLMGFIQADQSISFQ---AMRGKLQDFM-KIIRDDP--AVDNVTGFTGGSRV------NSGMMFITLKPls 617
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  636 ECILSPENVIARFLEEAKNPDGLELSI----------RQDENSLSSLLGSegapivvevkgEELDEIAKITGEVKERMQE 705
Cdd:PRK10614  618 ERSETAQQVIDRLRVKLAKEPGANLFLmavqdirvggRQSNASYQYTLLS-----------DDLAALREWEPKIRKALAA 686
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  706 VDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQL-----KQQLSGKEAGKMEYRGEMRDIVIKVPDISlgALG 780
Cdd:PRK10614  687 LPELADVNSDQQDKGAEMALTYDRDTMARLGIDVQAANSLLnnafgQRQISTIYQPLNQYKVVMEVDPRYTQDIS--ALE 764
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  781 SL-VIRSGTQEFLLDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDIDLPANYSITVTGEEEK 859
Cdd:PRK10614  765 KMfVINNEGKAIPLSYFAKWQPANAPLSVNHQGLSAASTISFNLPTGKSLSDASAAIERAMTQLGVPSTVRGSFAGTAQV 844
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  860 RQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIIL 939
Cdd:PRK10614  845 FQETMNSQLILILAAIATVYIVLGILYESYVHPLTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMM 924
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  940 VD-RINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIPCV 1018
Cdd:PRK10614  925 VDfALEAQRNGNLTAQEAIFQACLLRFRPIMMTTLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVV 1004
                        1050
                  ....*....|....*...
gi 491930720 1019 YYVLEKIKRRINHRTKKS 1036
Cdd:PRK10614 1005 YLFFDRLRLRFSRKPKQT 1022
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
12-1035 4.17e-81

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 285.86  E-value: 4.17e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   12 PVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRL-FIELKVGERP-------PEEIEKQFVKnmesmairQSDVTQVSS 83
Cdd:PRK10503   20 PVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIqVVTLYPGASPdvmtsavTAPLERQFGQ--------MSGLKQMSS 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   84 VIKAGTARITVEYTWTKDMDEAFLDLQKAMNPfAQNKEITELKITQHDANLSP---------VVLVGMSHQNITDMAELR 154
Cdd:PRK10503   92 QSSGGASVITLQFQLTLPLDVAEQEVQAAINA-ATNLLPSDLPNPPVYSKVNPadppimtlaVTSTAMPMTQVEDMVETR 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  155 riaesyIRNELIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELGLQYLVKSSSLF 234
Cdd:PRK10503  171 ------VAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSANDQM 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  235 STEADFENLIVGYKpvqqetsgnsssetvtdlNKAPVFLKEVATVQfvnARPENI---VRINGKRSIGLSIYKEMRFNTV 311
Cdd:PRK10503  245 QSAEEYRQLIIAYQ------------------NGAPIRLGDVATVE---QGAENSwlgAWANKQQAIVMNVQRQPGANII 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  312 KVVDEVTSRLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATF 390
Cdd:PRK10503  304 ATADSIRQMLPQLTESLPkSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTF 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  391 NLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHG 470
Cdd:PRK10503  384 AVMVFLDFSINNLTLMALTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGD 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  471 ASGELFKDQAWTVTFSLVSSLFVAILVIPMLYTQL----SGKKVKMEEVKSIR-----ITRYSKILRKLVRHRWWVIGMA 541
Cdd:PRK10503  464 IVGRLFREFAVTLAVAILISAVVSLTLTPMMCARMlsqeSLRKQNRFSRASERmfdrvIAAYGRGLAKVLNHPWLTLSVA 543
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  542 VLLLVVTGLLTPFIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTIVGGDSLCtiySHVGEgSGSENAIf 621
Cdd:PRK10503  544 LSTLLLTVLLWIFIPKGFFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLT---SFVGV-DGTNPSL- 618
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  622 egeNTAMMKIILFPeciLSPEN-----VIARFLEEAKNPDGLELSIrQDENSLSSLLGSEGAPIVVEVKGEELDEIAKIT 696
Cdd:PRK10503  619 ---NSARLQINLKP---LDERDdrvqkVIARLQTAVAKVPGVDLYL-QPTQDLTIDTQVSRTQYQFTLQATSLDALSTWV 691
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  697 GEVKERMQEVDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQL----KQQL-SGKEAGKMEYRGEMRDIVIKV 771
Cdd:PRK10503  692 PKLMEKLQQLPQLSDVSSDWQDKGLVAYVNVDRDSASRLGISMADVDNALynafGQRLiSTIYTQANQYRVVLEHNTENT 771
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  772 PdiSLGALGSLVIRSGTQEFL-LDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDIDLPANYS 850
Cdd:PRK10503  772 P--GLAALDTIRLTSSDGGVVpLSSIATIEQRFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPADIT 849
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  851 ITVTGEEEKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGG 930
Cdd:PRK10503  850 TQFQGSTLAFQSALGSTVWLIVAAVVAMYIVLGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIG 929
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  931 IAVNNSIILVD-RINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTL 1009
Cdd:PRK10503  930 IVKKNAIMMIDfALAAEREQGMSPRDAIYQACLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQV 1009
                        1050      1060
                  ....*....|....*....|....*.
gi 491930720 1010 MSLMVIPCVYYVLEKIKRRINHRTKK 1035
Cdd:PRK10503 1010 LTLFTTPVIYLLFDRLALYTKSRFPR 1035
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
6-1028 3.83e-73

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 262.84  E-value: 3.83e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    6 KFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESMAIRQSDVTQVSSVI 85
Cdd:PRK10555    3 NFFIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   86 KA-GTARITVEYTWTKDMDEAFLD----LQKAMNPFAQNKEITELKITQH-DANLSPVVLVG----MSHQNITDMAElrr 155
Cdd:PRK10555   83 SGtGQASVTLSFKAGTDPDEAVQQvqnqLQSAMRKLPQAVQNQGVTVRKTgDTNILTIAFVStdgsMDKQDIADYVA--- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  156 iaeSYIRNELIRLEGVAEVTLSGEEVTtLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSEL------GLQYLVK 229
Cdd:PRK10555  160 ---SNIQDPLSRVNGVGDIDAYGSQYS-MRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLGGTpsvdkqALNATIN 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  230 SSSLFSTEADFENLIVgykPVQQETSgnsssetvtdlnkaPVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFN 309
Cdd:PRK10555  236 AQSLLQTPEQFRDITL---RVNQDGS--------------EVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGAN 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  310 TVKVVDEVTSRLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVA 388
Cdd:PRK10555  299 EMATAKLVLNRLDELAQYFPhGLEYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMG 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  389 TFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFR-NQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVY 467
Cdd:PRK10555  379 TFSVLYAFGYSINTLTMFAMVLAIGLLVDDAIVVVENVERiMSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAF 458
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  468 LHGASGELFKDQAWTVTFSLVSSLFVAILVIPMLYTQLSgKKVKMEEVKSIR-------------ITRYSKILRKLVRH- 533
Cdd:PRK10555  459 FGGTTGAIYRQFSITIVSAMVLSVLVAMILTPALCATLL-KPLKKGEHHGQKgffgwfnrmfnrnAERYEKGVAKILHRs 537
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  534 -RWWVIGMAVLLLVVTGLLTpfIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTiVGGDSLCTIYSHVGE 612
Cdd:PRK10555  538 lRWILIYVLLLGGMVFLFLR--LPTSFLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFT-HEKDNVMSVFATVGS 614
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  613 GSGSenaifEGENTAMMKIILFPECILSPEN-----VIARF------LEEAKnpdglelSIRQDENSLSSLLGSEGAPIV 681
Cdd:PRK10555  615 GPGG-----NGQNVARMFIRLKDWDERDSKTgtsfaIIERAtkafnkIKEAR-------VIASSPPAISGLGSSAGFDME 682
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  682 VEVK-GEELDEIAKITGEVKERMQEVDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEY 760
Cdd:PRK10555  683 LQDHaGAGHDALMAARNQLLALAAKNPELTRVRHNGLDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMD 762
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  761 RGEMRDIVIK-------VP-DISLgalgsLVIRSGTQEFLLDEIASITHGQAPKEILRRNQSR-----IGKIMANMDTGK 827
Cdd:PRK10555  763 RGRVKKVYVQaaapyrmLPdDINL-----WYVRNKDGGMVPFSAFATSRWETGSPRLERYNGYsaveiVGEAAPGVSTGT 837
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  828 SLDKVAAEVRlavkdiDLPANYSITVTGE--EEKRQESMHSLLFAllLSVVLVYMVMASQFESLLHPFTILLTIPLAVVG 905
Cdd:PRK10555  838 AMDIMESLVK------QLPNGFGLEWTAMsyQERLSGAQAPALYA--ISLLVVFLCLAALYESWSVPFSVMLVVPLGVIG 909
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  906 AILLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFG 985
Cdd:PRK10555  910 ALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFANEMNQKGHDLFEATLHASRQRLRPILMTSLAFIFGVLPMATS 989
                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|...
gi 491930720  986 FGEGASLRSPMAIAVIGGLITSTLMSLMVIPcVYYVLekIKRR 1028
Cdd:PRK10555  990 TGAGSGSQHAVGTGVMGGMISATILAIFFVP-LFFVL--VRRR 1029
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
6-1032 8.54e-71

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 255.93  E-value: 8.54e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    6 KFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESMAIRQSDVTQVSSVI 85
Cdd:PRK09577    3 RFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSATS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   86 KAGTARITVEYTWTKDMDEAFLDLQKAMNPF-AQNKEITE---LKITQHDANLSPVVLVGMSHQNITDMaELRRIAESYI 161
Cdd:PRK09577   83 SAGQASLSLTFKQGVNADLAAVEVQNRLKTVeARLPEPVRrdgIQVEKAADNIQLIVSLTSDDGRLTGV-ELGEYASANV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  162 RNELIRLEGVAEVTLSGEEVTtLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSELG------LQYLVKSSSLFS 235
Cdd:PRK09577  162 LQALRRVEGVGKVQFWGAEYA-MRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIGRSAvpdsapIAATVFADAPLK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  236 TEADFENLivgykPVQQETSGNSssetvtdlnkapVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVD 315
Cdd:PRK09577  241 TPEDFGAI-----ALRARADGSA------------LYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEK 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  316 EVTSRLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMF 394
Cdd:PRK09577  304 RVRATMDELSRYFPpGVKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVML 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  395 FNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFR-NQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASG 473
Cdd:PRK09577  384 AAGFSINVLTMFGMVLAIGILVDDAIVVVENVERlMVEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVG 463
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  474 ELFKDQAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEEVKS----------IRIT-----RYSKILRKLVrhRWWVI 538
Cdd:PRK09577  464 NIYRQFALSLAVSIGFSAFLALSLTPALCATLLKPVDGDHHEKRgffgwfnrfvARSTqryatRVGAILKRPL--RWLVV 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  539 -GMAVLLLVVTGLLTPfigTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLL-------YTI-VGGdslctiYSH 609
Cdd:PRK09577  542 yGALTAAAALLFTRLP---TAFLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLrrhepvaYTFaLGG------FNL 612
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  610 VGEGSGSeNAIF---------EGENTAMMKIIlfpecilspENVIARFleeAKNPDGLELSIrqDENSLSSLLGSEGAPI 680
Cdd:PRK09577  613 YGEGPNG-GMIFvtlkdwkerKAARDHVQAIV---------ARINERF---AGTPNTTVFAM--NSPALPDLGSTSGFDF 677
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  681 VVEVKGE-ELDEIAKITGEVKERMQEVDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKME 759
Cdd:PRK09577  678 RLQDRGGlGYAAFVAAREQLLAEGAKDPALTDLMFAGTQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFM 757
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  760 YRGEMRDIVIKVPD---ISLGALGSLVIRSGTQEFL-LDEIASITHGQAPKEILRRNQSRIGKIMANMDTGKSLDKVAAE 835
Cdd:PRK09577  758 HGSQVRRVIVQADGrhrLDPDDVKKLRVRNAQGEMVpLAAFATLHWTLGPPQLTRYNGYPSFTINGSAAPGHSSGEAMAA 837
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  836 V-RLAVKdidLPANYSITVTGE--EEKRQESMHSLLFAllLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILlffi 912
Cdd:PRK09577  838 IeRIAAT---LPAGIGYAWSGQsfEERLSGAQAPMLFA--LSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVL---- 908
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  913 tGTTINMMG-----VIGIVMLGGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFG 987
Cdd:PRK09577  909 -GVTLRGMPndiyfKVGLIATIGLSAKNAILIVEVAKDLVAQRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASG 987
                        1050      1060      1070      1080
                  ....*....|....*....|....*....|....*....|....*
gi 491930720  988 EGASLRSPMAIAVIGGLITSTLMSLMVIPCVYYVLEKIKRRINHR 1032
Cdd:PRK09577  988 AASGAQIAIGTGVLGGVITATVLAVFLVPLFFVVVGRLFDVGPRR 1032
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
12-1024 4.91e-68

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 247.44  E-value: 4.91e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   12 PVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESMAIRQSDVTQVSSVIKAGTAR 91
Cdd:PRK09579   11 PVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQNFSI 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   92 ITVEYTWTKDMDEAFLDLQKAMNPFAQN--KEITELKITQHDANLSPVVLVG-----MSHQNITDMaeLRRIaesyIRNE 164
Cdd:PRK09579   91 ISIYARIGADSDRLFTELLAKANEVKNQlpQDAEDPVLSKEAADASALMYISfyseeMSNPQITDY--LSRV----IQPK 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  165 LIRLEGVAEVTLSGEEVTTLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGRVSElglQYLVKS----SSLFSTEAdf 240
Cdd:PRK09579  165 LATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKG---EYVVTSinasTELKSAEA-- 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  241 enlivgYKPVQQETSGNSSsetvtdlnkapVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKVVDEVTSR 320
Cdd:PRK09579  240 ------FAAIPVKTSGDSR-----------VLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAI 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  321 LAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGLT 399
Cdd:PRK09579  303 MPELESQLPpNLKVSIAYDATLFIQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYS 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  400 LNIMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFKDQ 479
Cdd:PRK09579  383 INLLTLLAMVLAIGLVVDDAIVVVENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEF 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  480 AWTVTFSLVSSLFVAILVIPMLYTQL-------SGKKVKMEEVKSIRITRYSKILRKLVRHRWWVIGMAVLLLVVTGLLT 552
Cdd:PRK09579  463 ALTLAGAVIISGIVALTLSPMMCALLlrheenpSGLAHRLDRLFERLKQRYQRALHGTLNTRPVVLVFAVIVLALIPVLL 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  553 PFIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDLLYTIVGGDSLCTIYSHVGEGSGSENAIF----EGENTAM 628
Cdd:PRK09579  543 KFTQSELAPEEDQGIIFMMSSSPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGFNGVQSGIGGFLLkpwnERERTQM 622
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  629 MkiiLFPECILSPENViarfleeaknpDGLELSirqdENSLSSLLGS-EGAP--IVVEVKGeELDEIAKITGEVKERMQE 705
Cdd:PRK09579  623 E---LLPLVQAKLEEI-----------PGLQIF----GFNLPSLPGTgEGLPfqFVINTAN-DYESLLQVAQRVKQRAQE 683
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  706 VDGVYDVVTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEYRGEMRDIVIKVPDI---SLGALGSL 782
Cdd:PRK09579  684 SGKFAFLDIDLAFDKPEVVVDIDRAKAAQMGVSMQDLGGTLATLLGEGEINRFTIDGRSYKVIAQVERPyrdNPGWLNNY 763
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  783 VIRSGTQEFL-LDEIASITHGQAPKEILRRNQ--SRIGKIMANMDTGKSLDKVAAEVRLavkdiDLPANYSITVTGEEEK 859
Cdd:PRK09579  764 YVKNEQGQLLpLSTLITLSDRARPRQLNQFQQlnSAIISGFPIVSMGEAIETVQQIARE-----EAPEGFAFDYAGASRQ 838
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  860 RQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIIL 939
Cdd:PRK09579  839 YVQEGSALWVTFGLALAIIFLVLAAQFESFRDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILI 918
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  940 VDRINQL-SQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIPCV 1018
Cdd:PRK09579  919 VEFANQLrHEQGLSRREAIEEAAAIRLRPVLMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCI 998

                  ....*.
gi 491930720 1019 YYVLEK 1024
Cdd:PRK09579  999 YTLLAK 1004
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
6-1034 5.72e-60

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 223.63  E-value: 5.72e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    6 KFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNME-SMAIRQSDVTQVSSV 84
Cdd:PRK15127    3 NFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEqNMNGIDNLMYMSSNS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   85 IKAGTARITVEYTWTKDMDEAFLD----LQKAMNPFAQnkEITELKITQHDANLSPVVLVG-------MSHQNITDMAEl 153
Cdd:PRK15127   83 DSTGTVQITLTFESGTDADIAQVQvqnkLQLAMPLLPQ--EVQQQGVSVEKSSSSFLMVVGvintdgtMTQEDISDYVA- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  154 rriaeSYIRNELIRLEGVAEVTLSGEEVTtLTVQTDPYKLNAFQLKIEDIASRIESNNQSISGGrvsELGLQYLVKSSSL 233
Cdd:PRK15127  160 -----ANMKDPISRTSGVGDVQLFGSQYA-MRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAG---QLGGTPPVKGQQL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  234 FSTeadfenLIVGYKPVQQETSGNSSSETVTDLNKapVFLKEVATVQFVNARPENIVRINGKRSIGLSIYKEMRFNTVKV 313
Cdd:PRK15127  231 NAS------IIAQTRLTSTEEFGKILLKVNQDGSR--VRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDT 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  314 VDEVTSRLAVIEDALP-GYHFQVISNQGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNL 392
Cdd:PRK15127  303 AAAIRAELAKMEPFFPsGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAV 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  393 MFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFR-NQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGA 471
Cdd:PRK15127  383 LAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERvMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGS 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  472 SGELFKDQAWTVTFSLVSSLFVAILVIPMLYTQL--------SGKKVK--------MEEVKSIRIT-RYSKILRK----L 530
Cdd:PRK15127  463 TGAIYRQFSITIVSAMALSVLVALILTPALCATMlkpiakgdHGEGKKgffgwfnrMFEKSTHHYTdSVGNILRStgryL 542
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  531 VRHRWWVIGMAVLLLVvtglltpfIGTEFMPRAESKAFTAVVKMPEGTQMERTAAAVGNLEDlLYTIVGGDSLCTIYSHV 610
Cdd:PRK15127  543 VLYLIIVVGMAYLFVR--------LPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTD-YYLTKEKNNVESVFAVN 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  611 GEGSGSenaifEGENTAMmkiilfpeCILSPENVIARFLEEAKNPDGLELSIRQDENSLSSLLGSEGAPIVVEV---KGE 687
Cdd:PRK15127  614 GFGFAG-----RGQNTGI--------AFVSLKDWADRPGEENKVEAITMRATRAFSQIKDAMVFAFNLPAIVELgtaTGF 680
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  688 ELDEI-------AKITGEVKERMQEVDGVYDVVTSI-----EDgAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEA 755
Cdd:PRK15127  681 DFELIdqaglghEKLTQARNQLLGEAAKHPDMLVGVrpnglED-TPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYV 759
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  756 GKMEYRGEMRDIVIK-------VPDislgALGSLVIRSGTQEFLLDEIASITHGQAPKEILRR-NQSRIGKIMANMDTGK 827
Cdd:PRK15127  760 NDFIDRGRVKKVYVMseakyrmLPD----DIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERyNGLPSMEILGQAAPGK 835
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  828 SLDKVAAEV-RLAVKdidLPA--NYSITVTGEEEKRQESMHSLLFAllLSVVLVYMVMASQFESLLHPFTILLTIPLAVV 904
Cdd:PRK15127  836 STGEAMELMeELASK---LPTgvGYDWTGMSYQERLSGNQAPALYA--ISLIVVFLCLAALYESWSIPFSVMLVVPLGVI 910
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  905 GAILLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRINQL-SQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMT 983
Cdd:PRK15127  911 GALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLmDKEGKGLIEATLEAVRMRLRPILMTSLAFILGVMPLV 990
                        1050      1060      1070      1080      1090
                  ....*....|....*....|....*....|....*....|....*....|.
gi 491930720  984 FGFGEGASLRSPMAIAVIGGLITSTLMSLMVIPcVYYVLekIKRRINHRTK 1034
Cdd:PRK15127  991 ISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVP-VFFVV--VRRRFSRKNE 1038
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
309-1028 2.51e-27

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 119.58  E-value: 2.51e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  309 NTVKVVDEVTSRLAVIEDalPGYHFQVISN---QGTFIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPIS 385
Cdd:COG1033   178 DRKEVVAEIRAIIAKYED--PGVEVYLTGFpvlRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLVVLLA 255
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  386 IVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPI 465
Cdd:COG1033   256 VIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSL 335
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  466 VYlhgASGELFKDQAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEEVKSIRitRYSKILRKL----VRHRWWVIGMA 541
Cdd:COG1033   336 LF---SDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPP--ELGRLLAKLarfvLRRPKVILVVA 410
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  542 VLLLVVTGLLTPFIGTEFMPRAEskaftavvkMPEGTQMERTAAAVgnledllytivggdslctiyshvgegsgseNAIF 621
Cdd:COG1033   411 LVLAVVSLYGISRLKVEYDFEDY---------LPEDSPIRQDLDFI------------------------------EENF 451
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  622 EGENTamMKIILfpecilspenviarfleEAKNPDGlelsIRQDENslssllgsegapivvevkgeeLDEIAkitgEVKE 701
Cdd:COG1033   452 GGSDP--LEVVV-----------------DTGEPDG----LKDPEV---------------------LKEID----RLQD 483
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  702 RMQEVDGVYDVvtsiedgapevvisidrtiaginnLSVATVIEQLKQQLSGkeaGKMEYRGemrdivikVPDISLGALGS 781
Cdd:COG1033   484 YLESLPEVGKV------------------------LSLADLVKELNQALNE---GDPKYYA--------LPESRELLAQL 528
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  782 LVIRSGTQEFLLDEIASITHGQAPkeilrrnqsrigkIMANMDTGKS--LDKVAAEVRLAVKDIDLPANYSITVTGE--- 856
Cdd:COG1033   529 LLLLSSPPGDDLSRFVDEDYSAAR-------------VTVRLKDLDSeeIKALVEEVRAFLAENFPPDGVEVTLTGSavl 595
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  857 -EEKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTI--PLAVVGAILLFFitGTTINMMGVIGIVMLGGIAV 933
Cdd:COG1033   596 fAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPNllPILLTFGLMGLL--GIPLNIATAVVASIALGIGV 673
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  934 NNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFgfgegASLR--SPMAIAVIGGLITSTLMS 1011
Cdd:COG1033   674 DYTIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLF-----SSFPplADFGLLLALGLLVALLAA 748
                         730
                  ....*....|....*..
gi 491930720 1012 LMVIPCVYYVLEKIKRR 1028
Cdd:COG1033   749 LLLLPALLLLLDPRIAK 765
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
2-512 1.28e-26

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 117.90  E-value: 1.28e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720    2 KNIVKFAVGNPVTICMIVFALLLLGKVSYDQLSVDLLPDLNNPRLFIELKVGERPPEEIEKQFVKNMESMAIRQSDVTQV 81
Cdd:COG0841   516 GRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIVSVQLPPGTSLERTEAVVRQVEEILLEVPEVESV 595
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   82 SSVIKAG-------TARITVEytwTKDMDEAFLD----LQKAMNPFAQNKEITELKITQHDANLSP-----VVLVGmshq 145
Cdd:COG0841   596 FSVVGFSgggsgsnSGTIFVT---LKPWDERDRSadeiIARLREKLAKIPGARVFVFQPPAGGLGSgapieVQLQG---- 668
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  146 niTDMAELRRIAESyIRNELIRLEGVAEVTLSGEEVT-TLTVQTDPYKLNAFQLKIEDIASRIesnNQSISGGRVSEL-- 222
Cdd:COG0841   669 --DDLEELAAAAEK-LLAALRQIPGLVDVRSDLQLGKpELQLDIDREKAAALGVTVADVASTL---RAALGGRYVNDFnr 742
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  223 -GLQYLVK---SSSLFSTEADFENLIVgykpvqqeTSGNSssetvtdlnkAPVFLKEVATVQFVNArPENIVRINGKRSI 298
Cdd:COG0841   743 gGREYDVRvqaPEEDRNSPEDLENLYV--------RTPDG----------EMVPLSSVATIEEGTG-PSSINRYNGQRSV 803
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  299 GLSIYKEMRFNTVKVVDEVTSRLAviEDALP-GYHFQVISNQGTFIKSAigevkSSAILGIVLAVIVLFVFL----RRMG 373
Cdd:COG0841   804 TVSANLAPGVSLGEALAAIEELAA--ELKLPpGVSIEFTGQAEEEQESF-----SSLGLAFLLALLLVYLVLaaqfESFI 876
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  374 TTLIVSLSIPISIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIA 453
Cdd:COG0841   877 QPLIILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFANQLREEGMSLREAILEAARLRLRPILM 956
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 491930720  454 STLTTIVVFLPIVYLHGASGELFKDQAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKM 512
Cdd:COG0841   957 TSLATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRRL 1015
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
698-1032 1.19e-17

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 88.51  E-value: 1.19e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   698 EVKERMQEVDGVYDVvTSIEDGAPEVVISIDRTIAGINNLSVATVIEQLKQQLSGKEAGKMEYRGEMRDIVIKVPDISLG 777
Cdd:pfam00873  160 NIKPQLSRVPGVGDV-QLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAE 238
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   778 ALGSLVIRSGT-QEFLLDEIASITHGQAPKEIL-RRNQSRIGKIMANMDTGKSLDKVAAEVRLAVKDID--LPANYSITV 853
Cdd:pfam00873  239 DFEKIIVKNQDgSPVRLRDVATVELGSELYRGFaTFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKptFPQGVEIVV 318
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   854 TGEE-EKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIA 932
Cdd:pfam00873  319 VYDTtPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLV 398
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   933 VNNSIILVDRINQ-LSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPM-TFGFGEGASLRsPMAIAVIGGLITSTLM 1010
Cdd:pfam00873  399 VDDAIVVVENIERvLEENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPIlFLGGLTGRIFR-QFAITIVLAILLSVLV 477
                          330       340
                   ....*....|....*....|..
gi 491930720  1011 SLMVIPCVYYVLEKIKRRINHR 1032
Cdd:pfam00873  478 ALTLTPALCATLLKPRREPKHG 499
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
148-514 1.93e-15

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 81.35  E-value: 1.93e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   148 TDMAELRRIAESyIRNELIRLEGVAEVTLsgEEVT---TLTVQTDPYKLNAFQLKIEDIASRIESNnqsiSGGRvselgl 224
Cdd:TIGR00914  691 DDLDDLDATAEK-ISAVLKGVPGAADVKV--EQTTglpYLTVEIDREKAARYGLTVGDVQDTVATA----VGGR------ 757
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   225 qylvKSSSLFSTEADFEnlIVGYKPVQQETSGNSSSE------TVTDLNKAPVFLKEVATVQFVNArPENIVRINGKRSI 298
Cdd:TIGR00914  758 ----MSGETFEGDRRFD--IVIRLPESLRESPQALRQlpiplpLSEDARKQFIPLSDVADLRVSPG-PNQISRENGKRRV 830
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   299 GLSIYKEMRfNTVKVVDEVTSRLAVIEDALPGYHfqvISNQGTF--IKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTL 376
Cdd:TIGR00914  831 VVSANVRGR-DLGSFVDDAKKAIAEQVKLPPGYW---ITWGGQFeqLQSATKRLQIVVPVTLLLIFVLLYAAFGNVKDAL 906
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   377 IVSLSIPISIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTL 456
Cdd:TIGR00914  907 LVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISFIRKLLEEGPSLDEAVYEGALTRVRPVLMTAL 986
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 491930720   457 TTIVVFLPIVYLHGASGELFKDQAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKMEE 514
Cdd:TIGR00914  987 VASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYRLVHRRRHKGRK 1044
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
823-1036 1.83e-14

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 77.98  E-value: 1.83e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  823 MDTGKSLDKVAAEVRLAVKDIDLPaNYSITVTGE----EEKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLT 898
Cdd:COG1033   173 LSSDLDRKEVVAEIRAIIAKYEDP-GVEVYLTGFpvlrGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSLRGVLLPLLV 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  899 IPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILA 978
Cdd:COG1033   252 VLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALREALRKLGPPVLLTSLTTAIG 331
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 491930720  979 MLpmTFGFGEGASLRSpMAIAVIGGLITSTLMSLMVIPCVYYVLEKIKRRINHRTKKS 1036
Cdd:COG1033   332 FL--SLLFSDIPPIRD-FGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPP 386
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
864-1032 2.35e-11

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 68.13  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  864 MHSLLFALLLsVVLVYMVMasqfesLLHP---FTILLTIPLAVVGAILLFFITGTTINMMgvigivMLGGIA------VN 934
Cdd:COG3696   338 TKNLLEGALL-VILVLFLF------LGNLraaLIVALAIPLSLLFAFIVMRLFGISANLM------SLGGLAidfgiiVD 404
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  935 NSIILVD------RINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLP-MTFGFGEGAsLRSPMAIAVIGGLITS 1007
Cdd:COG3696   405 GAVVMVEnilrrlEENRAAGTPRERLEVVLEAAREVRRPIFFATLIIILVFLPiFTLEGVEGK-LFRPMALTVIFALLGA 483
                         170       180
                  ....*....|....*....|....*
gi 491930720 1008 TLMSLMVIPCVYYVLekIKRRINHR 1032
Cdd:COG3696   484 LLLSLTLVPVLASLL--LRGKVPEK 506
secD TIGR01129
protein-export membrane protein SecD; Members of this family are highly variable in length ...
353-497 3.31e-11

protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273456 [Multi-domain]  Cd Length: 397  Bit Score: 66.54  E-value: 3.31e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   353 SAILGIVLAVIVLFVFLRRMGttLIVSLSIPISIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFRNQEK 432
Cdd:TIGR01129  253 AGLIGLVLVLVFMILYYRLFG--LIAAIALVINIVLILAILSAFGATLTLPGIAGLILTIGMAVDANVLIYERIKEELRL 330
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491930720   433 GVSVKEAVVTGTAEVANAVIASTLTTIVVFLpIVYLHGASgeLFKDQAWTVTFSLVSSLFVAILV 497
Cdd:TIGR01129  331 GKSVRQAIEAGFERAFSTIFDANITTLIAAL-ILYVFGTG--PVKGFAVTLAIGIIASLFTALVF 392
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
824-1028 5.67e-09

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 60.24  E-value: 5.67e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   824 DTGKSLDKVAAEVRLAVKDIDLPANYSITVTGE-------EEKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTIL 896
Cdd:TIGR00921  148 ADYKQVVPIYNDVERSLERTNPPSGKFLDVTGSpainydiEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVII 227
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   897 LTIPLAVVGAIllfFITGTTINMMGVIGIVMLGGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTI 976
Cdd:TIGR00921  228 LFGVAWVLGIM---GWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTS 304
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 491930720   977 LAMLPMtfgFGEGASLRSPMAIAVIGGLITSTLMSLMVIPCVYYVLEKIKRR 1028
Cdd:TIGR00921  305 AGFAAL---ALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIGREK 353
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
831-984 9.28e-09

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 59.63  E-value: 9.28e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   831 KVAAEVRLAVKDIDLPANYSITV--TGEEEKRQESM----HSLLFALLLSVVLVYMVMASQFESLLHPFTILLT--IPLA 902
Cdd:TIGR03480  229 KAINAIRAAAKDLRLDEDHGVTVrlTGEVALSDEELatvsEGATVAGLLSFVLVLVLLWLALRSPRLVFAVLVTliVGLI 308
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   903 VVGAILLFFITgtTINMMGVIGIVMLGGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTT---ILAM 979
Cdd:TIGR03480  309 LTAAFATLAVG--HLNLISVAFAVLFIGLGVDFAIQFSLRYREERFRGGNHREALSVAARRMGAALLLAALATaagFFAF 386

                   ....*
gi 491930720   980 LPMTF 984
Cdd:TIGR03480  387 LPTDY 391
SecD_SecF pfam02355
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF ...
831-1024 4.76e-08

Protein export membrane protein; This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC. SecD and SecF are required to maintain a proton motive force.


Pssm-ID: 280510 [Multi-domain]  Cd Length: 189  Bit Score: 54.15  E-value: 4.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   831 KVAAEVRLAVKDIDLPANYSITVTGEEEKRQESMHSLLFALLLsvVLVYMvmASQFEsLLHPFTILLTIPLAVVGAILLF 910
Cdd:pfam02355    1 VVEALLKNVGPDAEIISIETVGPTVGSELARKAVLALLFALLL--ILIYV--GLRFE-WRFALGAIIALAHDVIITVGVF 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   911 FITGTTINMMGVIGIVMLGGIAVNNSIILVDRI--NQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFgFGE 988
Cdd:pfam02355   76 SLFGIEVDLATVAALLTIIGYSVNDTVVVFDRVreNLRKKTRATLNEIMNLSINQTLTRTINTSLTTLLVVVALFV-FGG 154
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 491930720   989 GaSLRSpMAIAVIGGLITSTLMS-LMVIPCVYYVLEK 1024
Cdd:pfam02355  155 G-SLKD-FSLALLVGVIVGTYSSiFIASPILLDLGER 189
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
784-1035 8.79e-08

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 56.39  E-value: 8.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  784 IRSGTQEFLLDEIASITHGQAPKEILRRNQSRIGkimanmDTGKSLDKVAAEVRLAVKDID---LPANYSITVTGEEEKR 860
Cdd:PRK13024  503 VRADLKELGLGEVNIVTFGSDNNQVLVRTYGILS------DDEEADTEIVAKLKNALKNDKggtIPSSETVGPTVGKELA 576
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  861 QESMHSLLFALLlsVVLVYMVMasQFE---------SLLHPFTILLTIplavvgaillFFITGTTINMMGVIGIVMLGGI 931
Cdd:PRK13024  577 RNAIIAVLIALI--GILLYILI--RFEwtfslgailALLHDVLIVIGF----------FSLFRLEVDLTFIAAILTIIGY 642
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  932 AVNNSIILVDRINQLSQA--GMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFgFGeGASLRSpMAIAVIGGLITSTL 1009
Cdd:PRK13024  643 SINDTVVVFDRIRENLRLykKKDLREIVNKSINQTLSRTINTSLTTLLVLLALLI-FG-GSSLRN-FSLALLVGLIVGTY 719
                         250       260
                  ....*....|....*....|....*.
gi 491930720 1010 MSLMVIPCVYYVLEKIKRRINHRTKK 1035
Cdd:PRK13024  720 SSIFIAAPLWLDLEKRRLKKKKKRKK 745
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
310-538 3.93e-07

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 54.00  E-value: 3.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  310 TVKVVDEVTSRLAviEDALPGYHFQVISNQGT---FIKSAIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISI 386
Cdd:COG2409   130 AAEAVDALRDAVA--AAPAPGLTVYVTGPAALaadLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAV 207
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  387 VATFNLMFF-------NGLTLNIMTLGGLALGagmlVDNAIVVIeSIFRNQ-EKGVSVKEAVVTGTAEVANAVIASTLTT 458
Cdd:COG2409   208 GVALGLLALlaaftdvSSFAPNLLTMLGLGVG----IDYALFLV-SRYREElRAGEDREEAVARAVATAGRAVLFSGLTV 282
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  459 IV-----VFLPIVYLHGAsgelfkdqAWTVTFSLVSSLFVAILVIPMLYTqLSGKKV------KMEEVKSIRITRYSKIL 527
Cdd:COG2409   283 AIallglLLAGLPFLRSM--------GPAAAIGVAVAVLAALTLLPALLA-LLGRRVfwprrpRRRRAAAPESGFWRRLA 353
                         250
                  ....*....|.
gi 491930720  528 RKLVRHRWWVI 538
Cdd:COG2409   354 RAVVRRPVPVL 364
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
824-1016 1.23e-06

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 52.46  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  824 DTGKSLDKVAAEVRLAVKDIDlPANYSITVTGE----EEKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTI 899
Cdd:COG2409   125 DAGDEAAEAVDALRDAVAAAP-APGLTVYVTGPaalaADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTA 203
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  900 PLAVVGAILLFF-------ITGTTINMMGVIGIvmlgGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTT 972
Cdd:COG2409   204 GLAVGVALGLLAllaaftdVSSFAPNLLTMLGL----GVGIDYALFLVSRYREELRAGEDREEAVARAVATAGRAVLFSG 279
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 491930720  973 LTTILAMLPMTF-GFGegaSLRSpMAIAVIGGLITSTLMSLMVIP 1016
Cdd:COG2409   280 LTVAIALLGLLLaGLP---FLRS-MGPAAAIGVAVAVLAALTLLP 320
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
353-539 1.28e-06

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 52.54  E-value: 1.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  353 SAILGIVLAVIVLFVFLRRMGttLIVSLSIPISIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFRNQEK 432
Cdd:PRK13024  271 AGIIGFALIFLFMLVYYGLPG--LIANIALLLYIFLTLGALSSLGAVLTLPGIAGLVLGIGMAVDANVLIFERIKEELRK 348
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  433 GVSVKEAVVTGTAEVANAVIASTLTTIVVFLpIVYLHGASgeLFKDQAWTVTFSLVSSLFVAILVIPMLYTQLSGKKVKM 512
Cdd:PRK13024  349 GKSLKKAFKKGFKNAFSTILDSNITTLIAAA-ILFFFGTG--PVKGFATTLIIGILASLFTAVFLTRLLLELLVKRGDKK 425
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 491930720  513 EE---VKSIRITRYSKILRK-----LVRHRWWVIG 539
Cdd:PRK13024  426 PFlfgVKKKKIHNINEGVTIfdridFVKKRKWFLI 460
PRK13023 PRK13023
protein translocase subunit SecDF;
343-504 1.35e-06

protein translocase subunit SecDF;


Pssm-ID: 171842 [Multi-domain]  Cd Length: 758  Bit Score: 52.31  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  343 IKSAIGE-VKSSAILGIVLAVIV--LFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNA 419
Cdd:PRK13023  268 IASALGEdYASAAVLAALLAALVvgLFMVLSYGILGVIALVALVVNIIILTAVLSLIGASISLASIAGLVLTIGLAVDAH 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  420 IVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGELFkdqAWTVTFSLVSSLFVAILVIP 499
Cdd:PRK13023  348 ILIYERVREDRRKGYSVVQAMESGFYRALSTIVDANLTTLIAALVLFLLGSGTVHGF---ALTVAIGIGTTLFTTLTFTR 424

                  ....*
gi 491930720  500 MLYTQ 504
Cdd:PRK13023  425 LLIAQ 429
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
822-1016 1.35e-06

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 51.52  E-value: 1.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   822 NMDTGKSLDKVAAeVRLAVKDIDLPANYSITVTGE----EEKRQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILL 897
Cdd:pfam03176   96 DPGTTEADESVAA-VRDAVEQAPPPEGLKAYLTGPaatvADLRDAGDRDLGLIEAVTLVVIFIILLIVYRSVVAALLPLL 174
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   898 TIPL---------AVVGAILLFFITGTTINMMGVIGIvmlgGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPI 968
Cdd:pfam03176  175 TVGLslgaaqglvAILAHILGIGLSTFALNLLVVLLI----AVGTDYALFLVSRYREELRAGEDREEAVIRAVRGTGKVV 250
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 491930720   969 IMTTLTTILAMLPMTFgfgegASLRS--PMAIAVIGGLITSTLMSLMVIP 1016
Cdd:pfam03176  251 TAAGLTVAIAMLALSF-----ARLPVfaQVGPTIAIGVLVDVLAALTLLP 295
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
861-1036 1.46e-06

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 52.42  E-value: 1.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   861 QESMHSLLFALLLSVVLVYMVM---ASQFESLLHPftiLLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSI 937
Cdd:TIGR00915  334 EASIEEVVHTLIEAIVLVFLVMylfLQNFRATLIP---TIAVPVVLLGTFAVLAAFGFSINTLTMFAMVLAIGLLVDDAI 410
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   938 ILVDRINQL-SQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIP 1016
Cdd:TIGR00915  411 VVVENVERVmAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTP 490
                          170       180
                   ....*....|....*....|
gi 491930720  1017 CVYYVLEKIKRRINHRTKKS 1036
Cdd:TIGR00915  491 ALCATMLKPIEKGEHHEKKG 510
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
349-502 1.47e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 52.15  E-value: 1.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   349 EVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESiFR 428
Cdd:TIGR00921  568 GMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAER-YF 646
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491930720   429 NQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGAsgeLFKDQAWTVTFSLVSSLFVAILVIPMLY 502
Cdd:TIGR00921  647 EERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFP---IMRNFGLVQGIGVLSSLTAALVVFPALL 717
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
354-463 2.21e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 51.76  E-value: 2.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   354 AILGIVLAVIVLFVF--LRRMGTTLIVSLSipiSIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESIFRNQE 431
Cdd:TIGR00921  200 AISGILVVLVLLLDFkrWWRPLLPLVIILF---GVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYEEERD 276
                           90       100       110
                   ....*....|....*....|....*....|..
gi 491930720   432 KGVSVKEAVVTGTAEVANAVIASTLTTIVVFL 463
Cdd:TIGR00921  277 IGRAKGEAIVTAVRRTGRAVLIALLTTSAGFA 308
3a0501s07 TIGR00966
protein-export membrane protein SecF; This bacterial protein is always found with the ...
788-1014 2.50e-06

protein-export membrane protein SecF; This bacterial protein is always found with the homologous protein-export membrane protein SecD. In numerous lineages, this protein occurs as a SecDF fusion protein. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273368 [Multi-domain]  Cd Length: 246  Bit Score: 49.96  E-value: 2.50e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   788 TQEFLLDEIASITHGQAPKEILRRNQSRIGKIMANMDTgkSLDKVAAEVRLAVKDIDLPANYSITVTGEE--------EK 859
Cdd:TIGR00966   19 EQAADVAEVRDVLEKAGIEGVVIQEFGSSHTIMIRIPT--LDTEQSEELREALEEALKNVDPDAEIRSIDavgpsvggEL 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   860 RQESMHSLLFALLLsvVLVYMvmASQFE---------SLLHPFTILLTIplavvgaillFFITGTTINMMGVIGIVMLGG 930
Cdd:TIGR00966   97 ARKAVLALLAALVL--ILIYI--TVRFEwrfalgaivALVHDVIITVGV----------YSLFGIEVNLTTVAALLTIIG 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   931 IAVNNSIILVDRI--NQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFgFGEGaSLRSpMAIAVIGGLITST 1008
Cdd:TIGR00966  163 YSINDTVVVFDRIreNLRKYTRKTFTEVINLSINQTLSRTINTSLTTLLAVLALYV-FGGG-VIKD-FSLALLVGVIVGT 239

                   ....*.
gi 491930720  1009 LMSLMV 1014
Cdd:TIGR00966  240 YSSIFI 245
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
863-1036 2.74e-06

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 51.44  E-value: 2.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  863 SMHSLLFALLLSVVLVYMVM---ASQFESLLHPfTIllTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIIL 939
Cdd:PRK15127  336 SIHEVVKTLVEAIILVFLVMylfLQNFRATLIP-TI--AVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVV 412
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  940 VDRINQ-LSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIPCV 1018
Cdd:PRK15127  413 VENVERvMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPAL 492
                         170
                  ....*....|....*...
gi 491930720 1019 YYVLEKIKRRINHRTKKS 1036
Cdd:PRK15127  493 CATMLKPIAKGDHGEGKK 510
secD PRK05812
preprotein translocase subunit SecD; Reviewed
353-515 1.14e-05

preprotein translocase subunit SecD; Reviewed


Pssm-ID: 235615 [Multi-domain]  Cd Length: 462  Bit Score: 49.07  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  353 SAILGIVLAVIVLFVFLRRMGttLIVSLSIPISIVATFNLMFFNGLTLnimTL---GGLALGAGMLVDNAIVVIESI--- 426
Cdd:PRK05812  302 AGLIGLALVLLFMILYYRLFG--LIANIALVANLVLILAVLSLLGATL---TLpgiAGIVLTIGMAVDANVLIFERIree 376
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  427 FRNqekGVSVKEAVVTGTAEVANAVIASTLTTIVVFLpIVYLHGaSGELfKDQAWTVTFSLVSSLFVAILVIPMLYTQLS 506
Cdd:PRK05812  377 LRE---GRSLRSAIEAGFKRAFSTILDSNITTLIAAI-ILYALG-TGPV-KGFAVTLGIGILTSMFTAITVTRALVNLLY 450

                  ....*....
gi 491930720  507 GKKVKMEEV 515
Cdd:PRK05812  451 GRRKRLKKL 459
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
250-518 1.93e-05

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 48.96  E-value: 1.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   250 VQQETSGNSSSETVTDL---NKAPVF--LKEVATVQFVNARPEnIVRINGKRSIGLSIYKEMRFNTVKVVDEVtsrlAVI 324
Cdd:TIGR00915  772 VQAEEDARMSPEDINKWyvrNASGEMvpFSAFATVRWEYGSPQ-LERYNGLPSMEILGSAAPGVSTGQAMAAM----EAI 846
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   325 EDALP---GYHFQVISNQgtfiksaigEVKSSAILGIVLAVIVLFVFL------RRMGTTLIVSLSIPISIVATFNLMFF 395
Cdd:TIGR00915  847 AQKLPpgfGFSWTGMSYE---------ERLSGSQAPALYALSLLVVFLclaalyESWSIPVSVMLVVPLGIIGALLATTL 917
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   396 NGLTLNIMTLGGLALGAGMLVDNAIVVIESIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLHGASGEL 475
Cdd:TIGR00915  918 RGLSNDVYFQVGLLTTIGLSAKNAILIVEFAKELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGS 997
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 491930720   476 FKDQAWTVTFSLVSSLFVAILVIPMLY----TQLSGKKVKMEEVKSI 518
Cdd:TIGR00915  998 QHAIGTGVFGGMVTATVLAIFFVPLFYvvvrRLFKRKAHEKEMSVEH 1044
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
354-501 3.41e-05

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 48.07  E-value: 3.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   354 AILGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDNAIVVIESiFRNqekG 433
Cdd:TIGR03480  718 FIYALVAITVLLLLTLRRVRDVLLVLAPLLLAGLLTVAAMVLLGIPFNFANIIALPLLLGLGVDFGIYMVHR-WRN---G 793
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 491930720   434 VSVKEAVVTGTAEvanAVIASTLTTIVVFLPIVYLHG---AS-GELfkdqawtVTFSLVSSLFVAILVIPML 501
Cdd:TIGR03480  794 VDSGNLLQSSTAR---AVFFSALTTATAFGSLAVSSHpgtASmGIL-------LSLGLGLTLLCTLIFLPAL 855
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
861-1035 6.69e-05

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 47.13  E-value: 6.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  861 QESMHSLLFALLLSVVLVYMVM---ASQFESLLHPfTIllTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSI 937
Cdd:PRK10555  334 KASIEDVVKTLLEAIALVFLVMylfLQNFRATLIP-TI--AVPVVLMGTFSVLYAFGYSINTLTMFAMVLAIGLLVDDAI 410
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  938 ILVDRINQL-SQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFGFGEGASLRSPMAIAVIGGLITSTLMSLMVIP 1016
Cdd:PRK10555  411 VVVENVERImSEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVLSVLVAMILTP 490
                         170
                  ....*....|....*....
gi 491930720 1017 CVYYVLEKIKRRINHRTKK 1035
Cdd:PRK10555  491 ALCATLLKPLKKGEHHGQK 509
PRK14726 PRK14726
protein translocase subunit SecDF;
845-1009 7.44e-05

protein translocase subunit SecDF;


Pssm-ID: 237805 [Multi-domain]  Cd Length: 855  Bit Score: 47.02  E-value: 7.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  845 LPAnysiTVTGEEEKR------QESMHSLLFALLLSVVLV--YMVMASQFESLLHpfTILLTIPLAVVGAILLffITGTT 916
Cdd:PRK14726  350 LPA----TLTVVEERTvgpglgADSIAAGLVAGLIAAILVaaLMIGFYGFLGVIA--VIALIVNVVLIIAVLS--LLGAT 421
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  917 INMMGVIGIVMLGGIAVNNSIILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLpMTFGFGEGASlrSPM 996
Cdd:PRK14726  422 LTLPGIAGIVLTIGMAVDSNVLIYERIREEEKTGHSLIQALDRGFSRALATIVDANVTILIAAV-ILFFLGSGAV--RGF 498
                         170
                  ....*....|...
gi 491930720  997 AIAVIGGLITSTL 1009
Cdd:PRK14726  499 AVTLAVGILTTVF 511
COG4258 COG4258
Predicted exporter [General function prediction only];
356-462 1.42e-04

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 46.00  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  356 LGIVLAVIVLFVFLRRMGTTLIVSLSIPISIVATFNLMFFNGLTLNIMTLGGLALGAGMLVDnaivviESIFrNQEKGVS 435
Cdd:COG4258   647 LALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGID------YALF-FTEGLLD 719
                          90       100
                  ....*....|....*....|....*..
gi 491930720  436 VKEAVVTGTaevanAVIASTLTTIVVF 462
Cdd:COG4258   720 KGELARTLL-----SILLAALTTLLGF 741
PRK14726 PRK14726
protein translocase subunit SecDF;
346-494 2.23e-04

protein translocase subunit SecDF;


Pssm-ID: 237805 [Multi-domain]  Cd Length: 855  Bit Score: 45.48  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  346 AIGEVKSSAILGIVLAVIVLFVFLRRMGTTLIVSLSIPIS-IVATFNLMffnGLTLNIMTLGGLALGAGMLVDNAIVVIE 424
Cdd:PRK14726  370 SIAAGLVAGLIAAILVAALMIGFYGFLGVIAVIALIVNVVlIIAVLSLL---GATLTLPGIAGIVLTIGMAVDSNVLIYE 446
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  425 SIFRNQEKGVSVKEAVVTGTAEVANAVIASTLTTIVVFLPIVYLhgaSGELFKDQAWTVTFSLVSSLFVA 494
Cdd:PRK14726  447 RIREEEKTGHSLIQALDRGFSRALATIVDANVTILIAAVILFFL---GSGAVRGFAVTLAVGILTTVFTA 513
SecF COG0341
Preprotein translocase subunit SecF [Intracellular trafficking, secretion, and vesicular ...
868-1014 6.24e-04

Preprotein translocase subunit SecF [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440110 [Multi-domain]  Cd Length: 291  Bit Score: 43.12  E-value: 6.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  868 LFALLLSVVLVYMVMASQFE---------SLLHpfTILLTIplavvGailLFFITGTTINMMGVIGIVMLGGIAVNNSII 938
Cdd:COG0341   136 LLALLVALIGILIYIAFRFEwrfavgavvALLH--DVLITL-----G---IFSLFGLEFDLTFIAALLTIIGYSLNDTVV 205
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491930720  939 LVDRI--NQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFgFGeGASLRSpMAIAVIGGLITSTLMSLMV 1014
Cdd:COG0341   206 VFDRIreNLRKYRKMTLAEIINLSINQTLSRTINTSLTTLLVVLALLF-FG-GETLRD-FALALLIGIIVGTYSSIFI 280
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
860-1018 1.13e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 42.83  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  860 RQESMHSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPL-------AVV-----GAILLFFITGTTINMMGVIGIVM 927
Cdd:COG2409   512 SDALADDLPLVIPVVLGLIFLLLLLLFRSVVAPLKAVLTNLLslgaalgVLVlvfqhGWLLLGFTPGPLDSFVPLLLFVI 591
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  928 LGGIAVNNSIILVDRINQLSQAGMELTDAIVE-----------AGqqrirpIIMTTLTTILAMLPMTF----GFGegasl 992
Cdd:COG2409   592 LFGLGMDYEVFLVSRIREEYDRGGGTREAVIRglartgrvitsAA------LIMAAVFAAFATSPLVFlkqiGFG----- 660
                         170       180
                  ....*....|....*....|....*.
gi 491930720  993 rspMAIAViggLITSTLMSLMVIPCV 1018
Cdd:COG2409   661 ---LAVGV---LLDAFVVRMLLVPAL 680
secD TIGR01129
protein-export membrane protein SecD; Members of this family are highly variable in length ...
861-1014 2.41e-03

protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273456 [Multi-domain]  Cd Length: 397  Bit Score: 41.50  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720   861 QESMHSLLFALL--LSVVLVYMVMASQFESLLHPFTILLTIPLAVvgAILLFFitGTTINMMGVIGIVMLGGIAVNNSII 938
Cdd:TIGR01129  244 ADSIEAGIKAGLigLVLVLVFMILYYRLFGLIAAIALVINIVLIL--AILSAF--GATLTLPGIAGLILTIGMAVDANVL 319
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491930720   939 LVDRINQLSQAGMELTDAIvEAGQQRIRPIIM-TTLTTILAMLPMTFgFGEGASlrSPMAIAVIGGLITSTLMSLMV 1014
Cdd:TIGR01129  320 IYERIKEELRLGKSVRQAI-EAGFERAFSTIFdANITTLIAALILYV-FGTGPV--KGFAVTLAIGIIASLFTALVF 392
COG4258 COG4258
Predicted exporter [General function prediction only];
865-1016 2.66e-03

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 41.76  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  865 HSLLFALLLSVVLVYMVMASQFESLLHPFTILLTIPLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRIN 944
Cdd:COG4258   639 NDALWLLLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGIGIDYALFFTEGLL 718
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491930720  945 QlsqagmeltdaivEAGQQRIRP-IIMTTLTTILamlpmTFG---FGEGASLRSpMAIAVIGGLITSTLMSLMVIP 1016
Cdd:COG4258   719 D-------------KGELARTLLsILLAALTTLL-----GFGllaFSSTPALRS-FGLTVLLGILLALLLAPLLAP 775
PRK12911 PRK12911
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
860-1016 4.71e-03

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 171815 [Multi-domain]  Cd Length: 1403  Bit Score: 41.00  E-value: 4.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  860 RQESMHSLLFALllSVVLVYMVMasQFE---------SLLHpfTILLTIPLAVvgaILLFFITGTTINMMGVIGIVMLGG 930
Cdd:PRK12911 1233 RTQAVIALFGAL--GIILLYVSL--RFEwryafsaicALIH--DLLATCAVLV---ALHFFLQKIQIDLQAIGALMTVLG 1303
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  931 IAVNNSIILVDRINQLSQAGM--ELTDAIVEAGQQRIRPIIMTTLTTILAMLPMTFgFGeGASLRSPMAIAVIGGLItST 1008
Cdd:PRK12911 1304 YSLNNTLIIFDRIREDRQEKLftPMPILINDALQKTLGRTVMTTATTLSVLLILLF-VG-GGSIFNFAFIMTIGILL-GT 1380

                  ....*...
gi 491930720 1009 LMSLMVIP 1016
Cdd:PRK12911 1381 LSSLYIAP 1388
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
861-1014 8.08e-03

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 40.22  E-value: 8.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  861 QESMHSLLFALLLSVVLV--YMVMASQFesllhpFTILLTIPLAVVGAILLFFIT--GTTINMMGVIGIVMLGGIAVNNS 936
Cdd:PRK13024  262 QDAIDAGIIAGIIGFALIflFMLVYYGL------PGLIANIALLLYIFLTLGALSslGAVLTLPGIAGLVLGIGMAVDAN 335
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491930720  937 IILVDRINQLSQAGMELTDAIVEAGQQRIRPIIMTTLTTILAMLpMTFGFGEGaSLRSpMAIAVIGGLITSTLMSLMV 1014
Cdd:PRK13024  336 VLIFERIKEELRKGKSLKKAFKKGFKNAFSTILDSNITTLIAAA-ILFFFGTG-PVKG-FATTLIIGILASLFTAVFL 410
secF PRK13021
preprotein translocase subunit SecF; Reviewed
821-1014 8.16e-03

preprotein translocase subunit SecF; Reviewed


Pssm-ID: 237274 [Multi-domain]  Cd Length: 297  Bit Score: 39.45  E-value: 8.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  821 ANMDTGKSLDKVAAEVRLAVKDID-LPANYSITVTGEEEKRQESMhsllfALLLSVVLVYMVMASQFESLLHPFTiLLTI 899
Cdd:PRK13021   86 APADTAQSNVDIQQALAPLGTEVQvLNSSIVGPQVGQELAEQGGL-----ALLVAMLCILGYLSYRFEWRLASGA-LFAL 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491930720  900 PLAVVGAILLFFITGTTINMMGVIGIVMLGGIAVNNSIILVDRINQLSQAGMELtdAIVEAGQQRI-----RPIIM--TT 972
Cdd:PRK13021  160 VHDVIFVLAFFALTQMEFNLTVLAAVLAILGYSLNDSIIIADRIRELLIAKPKL--AIQEINNQAIvatfsRTMVTsgTT 237
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 491930720  973 LTTILAMLPMTFGFGEGaslrspMAIAVIGGLITSTLMSLMV 1014
Cdd:PRK13021  238 LMTVGALWIMGGGPLEG------FSIAMFIGILTGTFSSISV 273
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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