|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
10-425 |
5.29e-157 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 449.67 E-value: 5.29e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 10 MKVALASMVGTAIEFFDYYIYAAAAVLVFNTQFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLVAS 89
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 90 LVLMGGSTVVIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGT 169
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 170 FFLVSYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAEQKGKKLNAPVRVVFTKHLKPMIIGTFIMVAT 249
Cdd:cd17369 161 FLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 250 YSLFYIMTAFAQAYSRTApklseagyalgLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLGL 329
Cdd:cd17369 241 NVLFYLFTTFALSYATQT-----------LGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 330 AMPLFLENG-TPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLASIIGATIAAMISLKINASFG-VM 407
Cdd:cd17369 310 PFFWLLDTGsTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAATGsWW 389
|
410
....*....|....*...
gi 491949015 408 GVGIYLAINALMTFLALL 425
Cdd:cd17369 390 PVALYLAALAVISLVAAL 407
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
19-421 |
3.73e-152 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 437.09 E-value: 3.73e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 19 GTAIEFFDYYIYAAAAVLVFNTQFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLVASLVLMGGSTV 98
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 99 VIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGTFFLVSYLLG 178
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 179 HNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAEQKGKKLNAPVRVVFTKHLKPMIIGTFIMVATYSLFYIMTA 258
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 259 FAQAYSRTApklseagyalgLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLG-LAMPLFLEN 337
Cdd:TIGR00883 241 YLPTYLTQT-----------LGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAvPLLMALLDS 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 338 GTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLASIIGATIAAMISLKINASFG-VMGVGIYLAIN 416
Cdd:TIGR00883 310 GSFTLFFFLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGdWYAIGYYLAAL 389
|
....*
gi 491949015 417 ALMTF 421
Cdd:TIGR00883 390 ALIGL 394
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
2-430 |
1.77e-65 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 216.14 E-value: 1.77e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 2 STQLRNNPMKVALASMVGTAIEFFDYYIYAAAAVLVFNTQFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIG 81
Cdd:PRK09952 13 GTLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 82 RKKTLVASLVLMGGSTVVIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPI 161
Cdd:PRK09952 93 RKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 162 GLFVANGTFFLVSYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAEQK--GKKLNAPVRVVFTKHLKPM 239
Cdd:PRK09952 173 GLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEqaAAKKRIPVIEALLRHPGAF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 240 IIGTFIMVATYSLFYIMTAFAQAYSRTapklseagyalGLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKwlIW 319
Cdd:PRK09952 253 LKIIALRLCELLTMYIVTAFALNYSTQ-----------NLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRR--VY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 320 VTIAIGVLGLAMPLF--LENGTPVSV--FAFLVIGMAiMGMTFGPMAALLPELFPTEVRYSGASLAYNLASIIGATIAAM 395
Cdd:PRK09952 320 ITGALIGTLSAFPFFmaLEAQSIFWIvfFSIMLANIA-HDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPF 398
|
410 420 430
....*....|....*....|....*....|....*..
gi 491949015 396 ISLKINASFG--VMGVGIYLAINALMTFLALLASKET 430
Cdd:PRK09952 399 IAAALVTYFGgsWHSVAIYLLAGCLISAMTALLMKDN 435
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
14-431 |
2.88e-64 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 212.15 E-value: 2.88e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 14 LASMVGTAIEFFDYYIYAAAAvLVFNTQFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLVASLVLM 93
Cdd:cd17367 2 LGGSVGNLVEWYDWYVYAAFA-LYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 94 GGSTVVIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGTFFLV 173
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 174 SYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFvEAEQKGKKLNAPVRVVFTKHLKPMIIGTFIMVATYSLF 253
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESF-EAIAESNEASAGTLRELRRHPRELLLVVGLTAGGTLAF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 254 YIMTAFAQAYSRTApklseagyalgLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLGLAMPL 333
Cdd:cd17367 240 YTWTTYLQKFLVNT-----------AGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLS 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 334 FLENGTPVSVFAFLV-IGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLA-SIIGATiAAMISLKINASFGVMGVGI 411
Cdd:cd17367 309 ALDHTDSPYTAFALVlVGLVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAvAIFGGT-APYVALWLKSIGHEWVFFW 387
|
410 420
....*....|....*....|
gi 491949015 412 YLAINALMTFLALLASKETK 431
Cdd:cd17367 388 YVAGLIAISLVVYLRMPETR 407
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
11-435 |
1.26e-56 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 194.16 E-value: 1.26e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 11 KVALASMVGTAIEFFDYYIYAAAAvLVFNTQFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLVASL 90
Cdd:PRK10642 16 KAITAASLGNAMEWFDFGVYGFVA-YALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 91 VLMGGSTVVIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGTF 170
Cdd:PRK10642 95 VIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 171 FLVSYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVF---VEAEQKGKK--LNAPVRV----VFTKHLKPMII 241
Cdd:PRK10642 175 VLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFqqhVDKLEQGDRegLQDGPKVsfkeIATKHWRSLLT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 242 GTFIMVATYSLFYIMTAFAQAYSRTAPKLSEAgyalglgipantfTGFLLISAIVFG-IFIS-ISGFYADKIGRRKWLIW 319
Cdd:PRK10642 255 CIGLVIATNVTYYMLLTYMPSYLSHNLHYSED-------------HGVLIIIAIMIGmLFVQpVMGLLSDRFGRRPFVIL 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 320 VTIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLASIIGATIAAMISLK 399
Cdd:PRK10642 322 GSVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWL 401
|
410 420 430
....*....|....*....|....*....|....*.
gi 491949015 400 INASFGVMGVGIYLAINALMTFLALLASKETKNVDL 435
Cdd:PRK10642 402 VESTQNLMMPAYYLMVVAVIGLITGVTMKETANRPL 437
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
15-430 |
1.30e-52 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 180.63 E-value: 1.30e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 15 ASMVGTAIEFFDYYIYAAAAVLVfNTQFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLVASLVLMG 94
Cdd:cd17366 3 AAALGNAMEWFDFGVYGYLAVTI-GKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 95 GSTVVIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGTFFLVS 174
Cdd:cd17366 82 ASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 175 YLLGHNALVEWAWRIPFVSSILLVAVGLYVRltlheshvfveaeqkgkklnapvrvvftkhlKPMIIGTFIMVATYSLFY 254
Cdd:cd17366 162 LLLTEAQMLDWGWRIPFLIAAPLGLVGLYLR-------------------------------RPLLICIGLVLVFNVTNY 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 255 IMTAFAQAYSRTAPKLSEAgyalglgipantfTGFLLISAIVFGI--FISISGFYADKIGRRKWLIWVTIAIGVLGLAMP 332
Cdd:cd17366 211 MLLSYMPSYLEETLGYSET-------------HGLLVIIIIMVTMlvLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAF 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 333 LFLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLA-SIIGATIAAMISLKINASFGVMGVGI 411
Cdd:cd17366 278 LLMNSGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISvSLFGGTTPLVASWLVSATGNPLMPAY 357
|
410
....*....|....*....
gi 491949015 412 YLAINALMTFLALLASKET 430
Cdd:cd17366 358 YLMVAAVVGLVAVLFLTET 376
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
14-430 |
2.61e-50 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 175.25 E-value: 2.61e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 14 LASMVGTAIEFFDYYIYAAAAVLVFNTqFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLVASLVLM 93
Cdd:cd17368 2 LAATSGNALEFFDFGVYGFFAVYIGRL-FFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 94 GGSTVVIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGTFFLV 173
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 174 SYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAEQKGKKlNAPVRvVFTKHLKPMIIGTFIMVATYSLF 253
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTR-RELFA-LLANNRRIILLGMLLVAGSTVTF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 254 YIMTAFAQAYSRTApklseagyalgLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAigVLGLAMPL 333
Cdd:cd17368 239 YFTTVYTPTYAKTV-----------LGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLA--ALVTLYPV 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 334 FLENGTPVSVFAFLVIGM---AIMGMTFGPMAALLPELFPTEVRYSGASLAYNLA-SIIGATIAAMISLKINASFGVMGV 409
Cdd:cd17368 306 FAWLTAAPSFGRLLLVLLvlsFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAvAIFGGFAQFIVTWLIELTGSPLAP 385
|
410 420
....*....|....*....|.
gi 491949015 410 GIYLAINALMTFLALLASKET 430
Cdd:cd17368 386 AWYLMGAALLGLLATLMLRET 406
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
13-425 |
2.20e-41 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 150.06 E-value: 2.20e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 13 ALASMVGTAIEFFDYYIYAAAAVLVFntqffHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLVASLVL 92
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLA-----AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 93 MGGSTVVIGLLPNyaqigiwaPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGTFFL 172
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 173 VSYLLGHNalveWAWRIPFVSSILLVAVGLYVRltlheshvfveaeqkgkklnapvrvvftkhlKPMIIGTFIMVATYSL 252
Cdd:cd17316 148 LIPLLSGD----WGWRILFLIGALPALLALLLR-------------------------------RRTLLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 253 FYIMTAFAQAYsrtapklseagYALGLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLGLAMP 332
Cdd:cd17316 193 YYGLTTFLPTY-----------LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 333 LFLeNGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLASIIGATIAAMISLKINASFGVMGVGIY 412
Cdd:cd17316 262 YLL-SGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALI 340
|
410
....*....|...
gi 491949015 413 LAINALMTFLALL 425
Cdd:cd17316 341 LALLAIVALIVAL 353
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
19-425 |
3.72e-38 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 143.41 E-value: 3.72e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 19 GTAIEFFDYYIYAAAAvLVFNTQFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLVASLVLMGGSTV 98
Cdd:PRK10406 30 GNLVEWFDFYVYSFCS-LYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCMMCFGSL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 99 VIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGTFFLVSYLLG 178
Cdd:PRK10406 109 VIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQQTLE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 179 HNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHvfvEAEQKGKKLNAPVRVVFtKHLKpmiigTFIMV----ATYSL-F 253
Cdd:PRK10406 189 DAELREWGWRIPFALGAVLAVVALWLRRQLDETS---QQETRALKEAGSLKGLW-RNRR-----AFIMVlgftAAGSLcF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 254 YIMTAFAQAY-SRTApklseagyalglGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLGLAMP 332
Cdd:PRK10406 260 YTFTTYMQKYlVNTA------------GMHANVASGIMTAALFVFMLIQPLIGALSDKIGRRTSMLCFGSLAALFTVPIL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 333 LFLENGT-PVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLASIIGATIAAMISLKINASFGVMGVGI 411
Cdd:PRK10406 328 SALQNVSsPYAAFGLVMCALLIVSFYTSISGILKAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSIGMETAFFW 407
|
410
....*....|....
gi 491949015 412 YLAINALMTFLALL 425
Cdd:PRK10406 408 YVTLMAVVAFLVSL 421
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
19-397 |
1.74e-29 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 119.28 E-value: 1.74e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 19 GTAIEFFDYYIYAAAAVLVFNTqFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLVASLVLMGGSTV 98
Cdd:PRK15075 23 GNFLEMFDFFLFGFYATAIAKT-FFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGTL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 99 VIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVANGTFFLVSYLLG 178
Cdd:PRK15075 102 LIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQWLS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 179 HNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFveaeqKGKKLNAPVRVVFTKHLK--PMIIGTFIMVA-TYSLFYI 255
Cdd:PRK15075 182 PAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEF-----LARKHRPSMREIFRSLAAnwRIVLAGMLMVAmTTVSFYL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 256 MTAFAQAYSRTAPKLSEagyalglgipANTFTGFLLISAIVFgIFISISGFYADKIGRRKWLIWVTI-AIGVLGLAMPLF 334
Cdd:PRK15075 257 ITVYTPTFGKTVLHLSA----------ADSLLVTLCVGVSNF-IWLPIGGALSDRIGRRPVLIAFTVlAILTAYPALSWL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491949015 335 LENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLASIIGATIAAMIS 397
Cdd:PRK15075 326 VAAPSFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAIS 388
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
68-422 |
1.14e-25 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 107.77 E-value: 1.14e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQigiwapilLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17371 49 IGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARH 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVANgtffLVSYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAEQKGKKLNAP 227
Cdd:cd17371 121 RGKALGYVQSGWAVGWLLAT----LLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 228 V--RVVFTKHLKPMIIGTFIMVAT-YSLFYIMTAFAQAYSRTAPKLSEagyalglgipaNTFTGFLLISAIVFGIFISIS 304
Cdd:cd17371 197 PslRELFSPPLLRTTLLASLLATGaLGGYYGITTWLPSYLTGERGLSF-----------EGSAGYLVVTILGGFLGYLAG 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 305 GFYADKIGRRkWLIWVTIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMtFGPMAALLPELFPTEVRYSGASLAYNL 384
Cdd:cd17371 266 GFLADRIGRR-NNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGP-FSGMGAYLTELFPTAVRATAQGFCYNV 343
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 491949015 385 ASIIGA---TIAAMISLKIN--ASFGVMGVGIYLAINALMTFL 422
Cdd:cd17371 344 GRIIGAlfpFLVGFLATSGSlgTAIAVFAAVYYIAGLVLALLL 386
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
12-438 |
1.90e-19 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 90.02 E-value: 1.90e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 12 VALASMVGTAIEFFDYYIYAAAA----VLVFNTQFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKTLV 87
Cdd:pfam00083 1 VALVAALGGFLFGYDTGVIGAFLtlidFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 88 ASLVLMggstvVIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVAN 167
Cdd:pfam00083 81 IANVLF-----VIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 168 GTFFLVSYLLGhnalvEWAWRIPFVSSILLVAVGLYVRLTLHESHVF-------VEAEQKGKKLNAPVRV---------- 230
Cdd:pfam00083 156 IFGLGLNKTSN-----SDGWRIPLGLQLVPALLLIIGLLFLPESPRWlvekgrlEEAREVLAKLRGVPDVdreldeikds 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 231 -VFTKHLKPMIIGTFIMVATYS--LFY-IMTAFAQAYSRT------APKLSEAgyalgLGIPANTFTGFLLISAIVFGIF 300
Cdd:pfam00083 231 lEAGQEAEKASWKELFSTKTRRqrLLIgVMLQIFQQLTGInaifyySTTIFEN-----LGLSDSFLVTIIVGVVNFVFTF 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 301 ISIsgFYADKIGRRKWLIW--VTIAIGVLGLAMP-LFLENGTPVSVFAFLVIGM---AIMGMTFGPMAA-LLPELFPTEV 373
Cdd:pfam00083 306 IAI--FLVDRFGRRPLLLLgaAGMAICFVILGIVaLLGVSKSDWAGIVAIVFIAlfiAFFAMGWGPVPWvIVSELFPLSV 383
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491949015 374 RYSGASLAYNlASIIGATIAAMISLKINASFGVMGVG-IYLAINALMTFLALLASKETKNVDLTEI 438
Cdd:pfam00083 384 RSKAMALATA-ANWLANFLIGFLFPIITDAIGLGYTFfIFAGLLVLFIIFVFFFVPETKGRTLEEI 448
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-431 |
2.98e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.09 E-value: 2.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 7 NNPMKVALASMVGTAIEFFDYYIYAAAAVlVFNTQFFHSDDPLSNdllslsTLALAFFARPIGSALFGHFGDKIGRKKTL 86
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAP-PLAEEFGLSAAQLGL------LFAIPVLVGALLRIPLGFLVDRFGPRRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 87 VASLVLMGGSTVVIGLLPNYaqigiwapILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVA 166
Cdd:COG2223 74 LIGLLLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 167 NgtfFLVSYLLGHnalveWAWRIPF-VSSILLVAVGLYVRLTLHESHVFVEAEQKgKKLNAPVRVVFTKHLkpmIIGTFI 245
Cdd:COG2223 146 A---FLAPLLIAA-----FGWRNAFlILGILLLVVAVLAWLFLRDPPAGAAAAAK-ASLRDQLEALRDPRF---WLLSLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 246 MVATYSLFYIMTAFAQAYSRTApklseagyalgLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIG 325
Cdd:COG2223 214 YFGTFGSFIGFSSWLPPYLVDQ-----------FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 326 VLGLAMPLFLenGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLASIIGATIAAMISLKINASFG 405
Cdd:COG2223 283 LGLLLLALAL--GSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGS 360
|
410 420
....*....|....*....|....*.
gi 491949015 406 VMGVGIYLAINALMTFLALLASKETK 431
Cdd:COG2223 361 YTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
63-390 |
3.55e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 85.41 E-value: 3.55e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 63 FFARPIGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAqigiwapiLLCVCRVGQGIGLGGEWGGAALVATEN 142
Cdd:COG2814 55 LLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 143 APEGKRAWYGTFPQLGAPIGLFVAngtFFLVSYLLGHnalveWAWRIPF-VSSILLVAVGLYVRLTLHESHVFVEAEQKG 221
Cdd:COG2814 127 VPPERRGRALGLLGAGLGLGPALG---PLLGGLLADL-----FGWRWVFlVNAVLALLALLLLLRLLPESRPAARARLRG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 222 KKLNAPVRVVFtkhLKPMIIGTFIMVATYSLFYIMTAFAQAysrtapklseagyalGLGIPANTFTGFLLISAIVFGIFI 301
Cdd:COG2814 199 SLRELLRRPRL---LLLLLLAFLLGFGFFALFTYLPLYLQE---------------VLGLSASAAGLLLALFGLGGVLGA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 302 SISGFYADKIGRRKWLIwvtIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLA 381
Cdd:COG2814 261 LLAGRLADRFGRRRLLL---IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLY 337
|
....*....
gi 491949015 382 YNLASIIGA 390
Cdd:COG2814 338 NSAFFLGGP 346
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-308 |
4.58e-16 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 78.31 E-value: 4.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 8 NPMKVALASMVGTAIEFFDYYIYAAAAVLVfnTQFFHSDDPLsndllSLSTLALAFFARPIGSALFGHFGDKIGRKKTLV 87
Cdd:COG0477 11 RRRRALLALALGTFLEGLDFTIVNVALPSI--AADLGASSAQ-----LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 88 ASLVLMGGSTVVIGLLPNyaqigiwaPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFVAN 167
Cdd:COG0477 84 IGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 168 GTFFLVSYLLGhnalvewaWRIPFVSSILLVAVGLYVRLTLHESHVFVEAEQKGKKLNAPVRVVFTKHLKPMIIGTFIMV 247
Cdd:COG0477 156 LLGGLLVAALG--------WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLL 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491949015 248 ATYSLFYIMTAFAQAYSRTAPKLSEAGYALGLGIPANTFTGFLLISAIVFGIFISISGFYA 308
Cdd:COG0477 228 ALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-431 |
1.16e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 77.99 E-value: 1.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 2 STQLRNNPMKVALASMVGTAIEFFDYYIYAAAAVLVFNTQFFhsddplsNDLLSLSTLALAFFARPIGSALFGHFGDKIG 81
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGL-------SAAQLGLLASAFFLGYALGQIPAGLLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 82 RKKTLVASLVLMGGSTVVIGLLPNYAQigiwapilLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPI 161
Cdd:COG2271 74 RRRVLAIGLLLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 162 GLFVANgtfFLVSYLLGHnalveWAWRIPFVSSILLVAVGLYVRLtlheshvfveaeqkgkklnapvrvvftkhlkpmII 241
Cdd:COG2271 146 GGALAP---PLLGWLLAA-----FGWRAAFLILGLPGLLLALLRF---------------------------------WL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 242 GTFIMVATYSLFYIMTAFAQAYsrtapklseagYALGLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRR-KWLIWV 320
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTY-----------LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAI 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 321 TIAIGVLGLAMPLFLenGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAyNLASIIGATIAAMISLKI 400
Cdd:COG2271 254 GLLLAALALLLLALL--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV-NTFGFLGGALGPLLVGYL 330
|
410 420 430
....*....|....*....|....*....|..
gi 491949015 401 NASFGVMGV-GIYLAINALMTFLALLASKETK 431
Cdd:COG2271 331 LDATGYQAAfLLLAALALLAALLALLLLRETR 362
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
63-421 |
6.08e-15 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 76.66 E-value: 6.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 63 FFARPIGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAqigiwapiLLCVCRVGQGIGLGGEWGGAALVATEN 142
Cdd:PRK03893 65 FISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYW--------TLFIARLVIGMGMAGEYGSSATYVIES 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 143 APEGKRAWYGTFPQLGAPIGLFVANgtfFLVSYLLGHnalveWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAEQKGK 222
Cdd:PRK03893 137 WPKHLRNKASGFLISGFSIGAVVAA---QVYSLVVPV-----WGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKA 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 223 KLNAPVRVVFTKHLKPMIIG--TFIMVATYSLFYIMTA---------------FAQAYSRTAPKLSEAGYAL-------- 277
Cdd:PRK03893 209 PVRTMVDILYRGEHRIINILltLAAAAALWFCFAGNLQnaaivavlgllcaaiFISFMVQSSGKRWPTGVMLmvvvlfaf 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 278 ----------------GLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLiWVTIAIGVLgLAMPLFLENGTPV 341
Cdd:PRK03893 289 lyswpiqallptylktDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAY-VCSLLISQL-LIIPVFAIGGANV 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 342 SVFAFLVIGMAIMGMTfgpMAALLPEL----FPTEVRYSGASLAYN-------LASIIGATIAAMISLkiNASFGVMGVG 410
Cdd:PRK03893 367 WVLGLLLFFQQMLGQG---ISGLLPKLiggyFDTEQRAAGLGFTYNvgalggaLAPILGALIAQRLDL--GTALASLSFS 441
|
410
....*....|.
gi 491949015 411 IYLAINALMTF 421
Cdd:PRK03893 442 LTFVVILLIGL 452
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
63-422 |
2.26e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.07 E-value: 2.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 63 FFARPIGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQigiwapilLCVCRVGQGIGLGGEWGGAALVATEN 142
Cdd:cd17325 41 ALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ--------LLLARFLQGLASAAVWPAAMALIADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 143 APEGKRawygtfpqlGAPIGLF-VANGTFFLVSYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAEQKG 221
Cdd:cd17325 113 APPEER---------GRAMGIFsSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 222 KKLNAPVRVVFTKHLKPMIIGTFIMVATYSLFYIMTAFAQAYSRTAPKLSEAGYALglgipantftgFLLISAIVFGIFI 301
Cdd:cd17325 184 SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL-----------LFGAQGLASALSQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 302 SISGFYADKIGRRKWLIWVTIAIGVLGLAMPLFlenGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVR---YSGA 378
Cdd:cd17325 253 PPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRgtaMGLF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 491949015 379 SLAYNLASIIGATIAAMISLKINASFGVMGVGIYLAINALMTFL 422
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
7-425 |
5.84e-13 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 70.34 E-value: 5.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 7 NNPMKVALASM-VGTAIEFFDYyiyaaaaVLVFNTQFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRKKT 85
Cdd:PRK12307 13 TRPQKNALFSAwLGYVFDGFDF-------MLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 86 LVASLVLMGGSTVVIGLLPNYaqigiwapILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGLFV 165
Cdd:PRK12307 86 MMWSIVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNII 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 166 AngtfflvSYLLGHNALVeWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAEQKGKKLNAP---------VRVVFTKHL 236
Cdd:PRK12307 158 A-------AYFMPSFAEA-YGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQsawsvfslsMKGLFNRAQ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 237 KPMIIGTFIMvatysLFYIMTAFAQAYSRTAPKLSEAGYALGLGIPANTFTGF-LLISAIVFgifisisGFYADKIGRRK 315
Cdd:PRK12307 230 FPLTLCVFIV-----LFSIFGANWPIFGLLPTYLAGEGFDTGVVSNLMTAAAFgTVLGNIVW-------GLCADRIGLKK 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 316 wliwvTIAIGVLG---LAMPLFLengtpVSVFAFLVIGMAIMGMTFGPM--AALLPEL----FPTEVRYSGASLAYNLAS 386
Cdd:PRK12307 298 -----TFSIGLLMsflFIFPLFR-----IPQDNYLLLGACLFGLMATNVgvGGLVPKFlydyFPLEVRGLGTGLIYNLAA 367
|
410 420 430
....*....|....*....|....*....|....*....
gi 491949015 387 iIGATIAAMISLKINASFGvMGVGIYLAINALMTFLALL 425
Cdd:PRK12307 368 -TSGTFNSMAATWLGITMG-LGAALTFIVAFWTATILLI 404
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
68-390 |
5.68e-12 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 66.67 E-value: 5.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAqigiwapiLLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:pfam07690 47 LAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW--------LLLVLRVLQGLGAGALFPAALALIADWFPPEE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVAngtfFLVSYLLGHNALVEWAWRIPFVSSiLLVAVGLYVRLTLHESHVFVEAEQKGKKLNAP 227
Cdd:pfam07690 119 RGRALGLVSAGFGLGAALG----PLLGGLLASLFGWRAAFLILAILS-LLAAVLLLLPRPPPESKRPKPAEEARLSLIVA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 228 VRVVFTKHLKPMIIGTFIMVATYSLFYIMTAFaqaysrtapklseagYALGLGIPANTFTGFLLISAIVFGIFISISGFY 307
Cdd:pfam07690 194 WKALLRDPVLWLLLALLLFGFAFFGLLTYLPL---------------YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 308 ADKIGRRKWLIWVTIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLASI 387
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
|
...
gi 491949015 388 IGA 390
Cdd:pfam07690 339 GGA 341
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
68-409 |
1.62e-11 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 65.29 E-value: 1.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQigiwapilLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV--------LIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVAngtfFLVSYLLGHNalVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFVeaeqkgkklnap 227
Cdd:cd17315 121 RGALGTLNQLMITFGILLA----YLLGLALSLS--PPGWWRLMFALAAVPALLQLLLMFFLPESRALL------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 228 vrvvftkhlkpMIIGTFIMVA----TYSLFYIMTAFAQAYSRTAPKLseagyalglgipANTFTGFLlisaIVFGIFISI 303
Cdd:cd17315 183 -----------VGVGLQLLQQltgiNAVMYYAPTIFKSAGGGTASIL------------ASIIVGVV----NLLATLVAI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 304 sgFYADKIGRRKWLIW----VTIAIGVLGLA-MPLFLENGTPVSVFAFLVIGMAIMGMTFGPMAALL-PELFPTEVRYSG 377
Cdd:cd17315 236 --RLVDKVGRRPLLLIgfagMAASLLLLAIAfLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLlSEIFPLRIRGKG 313
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 491949015 378 ASLAYNL----ASIIGATIAAMISLKINAS----FGVMGV 409
Cdd:cd17315 314 MAIATLVnwifNFIVGLTFLIMVSTIGLAGvfifFAAVCL 353
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
72-426 |
1.52e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.59 E-value: 1.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 72 LFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQIGIWapillcvcRVGQGIGLGGEWGGAALVATENAPEGKRAwy 151
Cdd:cd17474 53 VAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAG--------RALQGIGAAGLGPLALTLIGDLFEGGERA-- 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 152 gtfpqlGAPIGLFVANGTFFLVSYLLGhNALVEWAWRIPFVSSILLVAVGLYVRLTLHEshvfvEAEQKGKKLNAPVRVV 231
Cdd:cd17474 123 ------KAMGLYEAALGLGIAVGPLLG-GLLAAISWRYPFFLLAALIPVAFLAILFLLP-----EPKEKAKSSSATKLRD 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 232 FTKHLKPMIIGTFiMVATYSLFYIMTAFaQAYSRTAPKLSEAGYALGLGIPANTFTGFLLISAIVFGIFIsisgfyADKI 311
Cdd:cd17474 191 LKKALRGRGLLTF-LVSAFLYFFLYFAF-LTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLL------KKRF 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 312 GRRKWLIwvtIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRySGASLAYNLASIIGAT 391
Cdd:cd17474 263 GARRILV---IGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEER-GTASSLYNFVRFLGQA 338
|
330 340 350
....*....|....*....|....*....|....*
gi 491949015 392 IAAMISLKINASFGVMGVGIYLAINALMTFLALLA 426
Cdd:cd17474 339 VGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
7-438 |
2.02e-10 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 62.36 E-value: 2.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 7 NNPMKVALASMVGTAIEFFDY---YIYAAAAVLVFNTQFFHSDDPLSNDLLSLSTLALAFFARPIGSALFGHFGDKIGRK 83
Cdd:TIGR00879 22 TYWKVALLSLIAAIGGLMFGYdtgVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRK 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 84 KTLvaslvLMGGSTVVIGLLPNYAQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKRAWYGTFPQLGAPIGL 163
Cdd:TIGR00879 102 KSL-----LIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 164 FVANGTFFLVSYLLGHNA-----LVEWAWRIPFVSSIL--------LVAVGLYVRLT---------------LHESHVFV 215
Cdd:TIGR00879 177 LVAYGFGSGKVSLNNTLGwriplGLQLIPAGLLFLGLFflpesprwLVGKGRVEEARkslarlrgtsgedkeLLDELELI 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 216 EAEQKGKKLNAPVRVVFTKHLKPMIIGTFIMVAtyslfyIMTAFAQ-----AYSRTAPKLSEAgyalgLGIPANTFTGFL 290
Cdd:TIGR00879 257 DIKRSIEKRSVQPSWGSLFSSTRRIRRRLFLGV------VLQWFQQftginAIMYYSPTIFEN-----AGVSTDHAFLVS 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 291 LISAIVFGIFISISGFYADKIGRRKWLIW--VTIAIGVLGLAMPLFLENGTPVSVFAFLVIGM-----AIMGMTFGPMAA 363
Cdd:TIGR00879 326 IIVGAVNFAFTFVAIFLVDRFGRRPLLLIgaAGMAICLFVLGILGASFVTGSSKSSGNVAIVFillfiAFFAMGWGPVPW 405
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491949015 364 LLP-ELFPTEVRYSGASLAYNlASIIGATIAAMISLKINASFGVMGVGI-YLAINALMTFLALLASKETKNVDLTEI 438
Cdd:TIGR00879 406 VIVsEIFPLSLRPKGISIAVA-ANWLANFIVGFLFPTMLESIGVGGVFIfFGGLNVLGLIFVYFFLPETKGRTLEEI 481
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
68-394 |
2.37e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 61.99 E-value: 2.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQIGIWapillcvcRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:TIGR00895 67 FGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLIL--------RFLAGLGLGGLMPNLNALVSEYAPKRF 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVANgtfFLVSYLLGHnalveWAWRIPF-VSSILLVAVGLYVRLTLHES--------------- 211
Cdd:TIGR00895 139 RGTAVGLMFCGYPIGAAVGG---FLAGWLIPV-----FGWRSLFyVGGIAPLLLLLLLMRFLPESidflvskrpetvrri 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 212 -------------HVFVEAEQKGKKLNAPVRVVFTKHlkpMIIGTFIMVATYSLFYIMTAFAQAYsrtAPKL-SEAGYAL 277
Cdd:TIGR00895 211 vnaiapqmqaeaqSALPEQKSTQGTKRSVFKALFQGK---TARITVLLWLLYFMLLVGVYFLTNW---LPKLmVELGFSL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 278 GLGipanTFTGFLLISAIVFGIFisISGFYADKIGRRkwliwvTIAIGVLGLAMPLFL----ENGTPVSVFAFLVIGMAI 353
Cdd:TIGR00895 285 SLA----ATGGALFNFGGVIGSI--IFGWLADRLGPR------VTALLLLLGAVFAVLvgstLFSPTLLLLLGAIAGFFV 352
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 491949015 354 MGMTFGpMAALLPELFPTEVRYSGASLAYN---LASIIGATIAA 394
Cdd:TIGR00895 353 NGGQSG-LYALMALFYPTAIRATGVGWAIGigrLGAIIGPILAG 395
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
68-427 |
7.54e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 60.26 E-value: 7.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAqigiwapiLLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVANGTFFLVSYLLGhnalvewaWRIPF-VSSILLVAVGLYVRLTLheSHVFVEAEQKGKKLNA 226
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG--------WRAAFlAIAVLALLAALLLWRLL--PSLPPKKPGSLGLLSS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 227 PVRVVFTKHLKPMIIGTFIMvatyslfyiMTAFAQAYSRTAPKLSEAGYALGLGIpantfTGFLLISAIVFGIFISISGF 306
Cdd:cd17324 191 LLLLLRNPRLRLAYLITFLL---------FGGFFALYTYLAPFLTDVPGFSSSAI-----IGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 307 YADKIGRRKwLIWVTIAIGVLGLAMPLFLenGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPtEVRYSGASL---AYN 383
Cdd:cd17324 257 LADRGGRRA-LLIALLLLAAALLLLTLLG--PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLylaAYN 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 491949015 384 LASIIGATIAAMISlkinASFGVMGVGIylaINALMTFLALLAS 427
Cdd:cd17324 333 LGGALGAALGGLVL----DHGGWAGVGW---VGAALLLLALLLA 369
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
68-425 |
1.20e-09 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 59.75 E-value: 1.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYaqigiwapILLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd06174 46 LLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVanGTFFLVSYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAEQKGKKLNAP 227
Cdd:cd06174 118 RGRALGLLQAFGSVGGIL--GPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 228 VRVVFtkHLKPMIIGTFIMVATYSLFYIMTAFAQAYSRTAPKLSEAGYALglgipantftgFLLISAIVFGIFISISGFY 307
Cdd:cd06174 196 LKRVL--KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL-----------LLSLFGLAGALGSLLLGLL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 308 ADKIGRRKWLIWVTIAIGVLGLAMPLFLenGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAYNLASI 387
Cdd:cd06174 263 SDRLIGRKPLLLIGLLLMALGLALLLLA--PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFL 340
|
330 340 350
....*....|....*....|....*....|....*...
gi 491949015 388 IGATIAAMISLKINASFGVMGVGIYLAINALMTFLALL 425
Cdd:cd06174 341 GGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
64-405 |
1.99e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.15 E-value: 1.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 64 FARPIGSALFGHFGDKIGRKKT-LVASLVLMGGSTVVIGLLPNYAQIG--IWAPILLCVCRVGQGIGLGGEWggaALVAT 140
Cdd:COG2211 61 ITDPLIGALSDRTRTRWGRRRPwILIGAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLAYTLVNIPYS---ALGAE 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 141 ENAPEGKRAWYGTFPQLGAPIGLFVANGTFFLVSYLLGHNAlvEWAWRIPF-VSSILLVAVGLYVRLTLHESHVFVEAEQ 219
Cdd:COG2211 138 LTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTAlIFAVLGLLAFLLTFFGTKERPVPEEEKV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 220 KGKKLnapVRVVFT-KHLKPMIIGTFIMVATYSLFYIMTAFAQAYSrtapklseagyalgLGIPANTFTGFLLISAIVFG 298
Cdd:COG2211 216 SLKES---LKALLKnRPFLLLLLAYLLFFLALALVAALLLYYFKYV--------------LGLSAALVGLLLALYFLAAL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 299 IFISISGFYADKIGRRKWLIWvTIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFP-----TEV 373
Cdd:COG2211 279 LGAPLWPRLAKRFGKKKAFII-GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewkTGR 357
|
330 340 350
....*....|....*....|....*....|...
gi 491949015 374 RYSGASLA-YNLASIIGATIAAMISLKINASFG 405
Cdd:COG2211 358 RREGLYFGiFTFAIKLGQALAGALAGLLLALFG 390
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
68-437 |
2.73e-09 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 58.87 E-value: 2.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYaqigiwapILLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNY--------TVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVangtFFLVSYLLGHnalveWAWrIPFVSSILLVAVGLYV--------------RLTLHESHV 213
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVL----LPLVAYFIPD-----WRW-LQLAVSLPTFLFFLLSwfvpesprwlisqgRIEEALKIL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 214 FVEAEQKGKKLNAPV-RVVFTKHLKPMIIGTFIMV-------ATYSLFYIMTAFAQAYSRtapklseagYALGLGIPA-- 283
Cdd:TIGR00898 284 QRIAKINGKKLPAEVlSLSLEKDLSSSKKQYSFLDlfrtpnlRKTTLCLMMLWFTTAFSY---------YGLVLDLGNlg 354
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 284 -NTFTGFLLISAIVFGIFISISgFYADKIGRRKWLIWVTIAIGVLGLAMpLFLENGTPVSVFAFLVIGMAIMGMTFGPMA 362
Cdd:TIGR00898 355 gNIYLDLFISGLVELPAKLITL-LLIDRLGRRYTMAASLLLAGVALLLL-LFVPVDLYFLRTALAVLGKFGITSAFQMVY 432
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491949015 363 ALLPELFPTEVRYSG---ASLAYNLASIIGATIAAMISLKINASFGVMGVGIYLAinALMTFLALlaskETKNVDLTE 437
Cdd:TIGR00898 433 LYTAELYPTVVRNLGvgvCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLA--GILTLFLP----ETKGVPLPE 504
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
68-418 |
3.15e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 58.35 E-value: 3.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAqigiwapiLLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFT--------IFIIARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVAngtfFLVSYLLGHNALVEW----AWRIPFVSSILLVAVGLYVRLTLHESHvfveaeqkgkk 223
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLA----YIVNYLIANAGGADWlgaeGWRWMLGLEAIPAILFLLGMLFIPESP----------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 224 lnapvRVVFTKHLKPMIIGtfIMVATY-------SLFYimtafaqaYSRTApkLSEAGYALGLGIPANTFTGFLLISAIV 296
Cdd:cd17359 188 -----RWLVSKGKPILIIG--IGLAIFqqfvginVIFY--------YGPEI--FQNAGFSENAALLQTIGIGVVNVIFTI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 297 FGIFIsisgfyADKIGRRKWLIW----VTIAIGVLGLAMPLFLENG-TPVSVFAFLVIGMAIMGMTFGP-MAALLPELFP 370
Cdd:cd17359 251 IAILL------VDKVGRKPLLLIgsigMAISLLLIGTAFYFAPGSQaSGIVALVLILLFVAFFAMSWGPvTWVLLSEIFP 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 491949015 371 TEVRYSGASLAYNLASIIGATIAAMISLkINASFGVMGV-GIYLAINAL 418
Cdd:cd17359 325 NRIRGLAMGIAVFFLWIANFLVSLTFPI-LLAAFGLAFTfLIFAVICVL 372
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
68-426 |
1.34e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 53.36 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQIGIWapillcvcRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17365 49 IGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL--------RFLTGLGLGAAMPNAITLVSEYAPARR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGlfvANGTFFLVSYLLGHnalveWAWRIPF-VSSILLVAVGLYVRLTLheshvfveaeqkgkklna 226
Cdd:cd17365 121 RSLAVTLMFCGYPLG---AALGGFLAAALIPA-----FGWRSVFlLGGVPPLILLPLLRGTL------------------ 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 227 pvrvvftkhlkpMIIGTFIMVATysLFYIMTAFAqaysrtaPKL-SEAGYALGlgiPANTFTGFLLISAIVFGIFIsisG 305
Cdd:cd17365 175 ------------LLWVTFFMGLL--LVYLLNSWL-------PKLmVEAGYSLS---QALTITLLLNIGGVIGSLLL---G 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 306 FYADKIGRRKWLIWvTIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMTFGpMAALLPELFPTEVRYSGASLAY--- 382
Cdd:cd17365 228 WLADRFGPKRVLAL-FFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVG-LYALAARFYPTEVRATGVGWALgvg 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 491949015 383 NLASIIGATIAAMIslkINASFGVMGVGIYLAINALMTFLALLA 426
Cdd:cd17365 306 RLGAILGPLLGGLL---LAAGLGPESVFLALAIPAALGALAVLL 346
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
68-438 |
1.35e-07 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 53.41 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLmggstVVIGLLPNYAQIGIWAPILlcVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVI-----YIIGAIIQVAAIGKWYQLI--VGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVANGTFFLVSYLLGHNalvewAWRIPFVSSI---LLVAVGLYvrlTLHEShvfveaeqkgkkl 224
Cdd:cd17356 133 RGTLVSLYQLAITIGILVAYCINYGTHKLDGSA-----QWRIPLGLQIvwgLLLLIGMF---FLPES------------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 225 napvrvvfTKHLKPMIIGTFIMV------ATYSLFYIMTAFAQAysrtapklseagyalGLGIPANTFTGflLISAIVFG 298
Cdd:cd17356 192 --------PRWLYRTILGIMLQLfqqltgINYFFYYGTTIFQST---------------GLTGSSPLLTS--IILYIVNF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 299 IFISISGFYADKIGRRKWLI----------WVTIAIGVLGLAMPLFL-----ENGTPVSVFAFLVIgmAIMGMTFGPMAA 363
Cdd:cd17356 247 VSTIPGLFFVDKFGRRTCLLigaagmsiclFIYAAVGVRYLIPNPQSgtsnkSAGNGMIVFICLFI--FSFATTWGPIAW 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491949015 364 LLP-ELFPTEVRYSGASLAYN---LASIIGATIAAMISLKINASFGVmgvgIYLAINALMTFLALLASKETKNVDLTEI 438
Cdd:cd17356 325 VYVaEVFPLRVRSKGMALATAfnwLWNFLISFFTPFIIGSIGFKYYY----IFAGCNLLAFIVVFFFVPETKGLTLEEI 399
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
68-409 |
1.44e-07 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 52.97 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAqigiwapiLLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVangtFFLVSYLLGHnalvewaWR-IPFVSSILLVAVGLYVRLTlheshvfveaeqkgkklna 226
Cdd:cd17317 112 RSFVGILFGLFWALGYML----LALLAYLIRD-------WRwLQLAISLPGLLFLLLLWWL------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 227 PVRvvftkhlkpMIIGTFIMVATYSLFYIMTAFAQAYSRtapklseagyalglgipaNTFTGFLLISAIVF-GIFISIsg 305
Cdd:cd17317 162 PRR---------TIIVGLIWFVTSLVYYGLSLNSSNLGG------------------NLYLNFFLSGLVEIpAYFLAL-- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 306 FYADKIGRRKWLIWVTIAIGVLGLAMpLFLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSG---ASLAY 382
Cdd:cd17317 213 LLLDRLGRRWTLSGSLLLAGLACLVT-ALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGvglCSTVA 291
|
330 340
....*....|....*....|....*..
gi 491949015 383 NLASIIGATIAAMISLKINASFGVMGV 409
Cdd:cd17317 292 RVGAILAPFIVLLGKIGPLLPLIIFGV 318
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
70-374 |
9.37e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 50.70 E-value: 9.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 70 SALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQigiwapilLCVCRVGQGIGLGGEWGGAALVATENAPEGKRA 149
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQ--------LLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 150 WYGTFPQLGAPIGLFVANGTFFLVSYLLGHnalvewaWRIPF-VSSILLVAVGLYVRLTLHESHVFVEAEQKGKKLNAPV 228
Cdd:cd17328 123 RALGVFYFAIPLGSGLGYVVGGLVAQATGG-------WRWAFrVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATS 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 229 RVVFTKHL---KPMII---GTFIMV-ATYSL-FYIMTAFAQAYSRTAPKLSEAGYALGLgipANTFTGFLlisAIVFGif 300
Cdd:cd17328 196 FLADLKALaknPSFILstlGFTAVSfVTGALaFWAPTFFLRAFGVGDLSSADVGLIFGA---ITCIAGVL---GVLLG-- 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 301 isisGFYADKIGRR--KWLIWVTiAIGVLGLAMPLFL----ENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVR 374
Cdd:cd17328 268 ----GILADRLRRKtpRADPLVC-AVGLLAAAPFLFLalvlALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRR 342
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
72-427 |
1.79e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.86 E-value: 1.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 72 LFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQIGiwapILLCVCRVGQGIGLGGEWGGAALVATENAPEGKrAWY 151
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLL----LLVALAGIGSAAFHPEGARLASQAAGGRRGLAM-SIF 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 152 GTFPQLGAPIGLFVAngtfflvSYLLGHNALVEWAWripfVSSILLVAVGLYVRLTLHESHVFVEAEQKGKKLNAPVRVV 231
Cdd:cd17478 125 SVGGNLGFALGPLIA-------AALVALFGGLGLLI----LLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 232 FtkhlKPMIIGTFIMVATYSLFYIMTAFAQAYSRTA-PKLSEAGYALGLgipantftgFLLISAIvfGIFisISGFYADK 310
Cdd:cd17478 194 W----RALLLLLIIVFLRSWVLSSLTTFLPFYLVQRgYSLVFAGLLLSL---------FLFAGAI--GTL--IGGPLSDR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 311 IGRRKWLIwvtIAIGVLGLAMPLFLENGTPVSVFAFLVIGmAIMGMTFGPMAALLPELFPTevrysGASLAYNLASIIGA 390
Cdd:cd17478 257 FGRRRVII---ASLLLAAPFLLLFLLTPGIWSYILLVLAG-FLLFASFPVTVVLAQELLPG-----NVGLASGLMMGLSF 327
|
330 340 350
....*....|....*....|....*....|....*..
gi 491949015 391 TIAAMISLKINASFGVMGVGIYLAINALMTFLALLAS 427
Cdd:cd17478 328 GLGGIGAPVLGALADAFGLESVLLILALLPLLGALLA 364
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
63-432 |
1.86e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.85 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 63 FFARPIGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQIGIWAPILLCVCRVGQgiglggewGGAALVATEN 142
Cdd:COG0738 53 FLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLD--------VAANPYVAAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 143 APEGKRA---WYGTFPQLGAPIGLfvangtfFLVSYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHvfVEAEQ 219
Cdd:COG0738 125 GPETAASrlnLLHAFFSLGALLGP-------LLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIE--EEEEE 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 220 KGKKLNAPVRVVFTKHLKPMIIGTFIMVATYslfYIMTAFAQAYSRTAPKLSEAGYALGLGIpantFTGFLLISAIVFGI 299
Cdd:COG0738 196 AAGSAASLKSLLKNPRLLLGGLAIFLYVGAE---GAIGDWLPLYLKDVLGLSEATAALGLSL----FWGGMTIGRFLGGF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 300 FIsisgfyaDKIGRRKWLIWVTIAIGVLGLAMPLFleNGTPVSVFAFLVIGMAiMGMTFGPMAALLPELFPTEVRYSGAS 379
Cdd:COG0738 269 LL-------KRFGPVRLLRLSALLAAVGLLLALLA--PGPWLALIGLALVGLG-LSLMFPTIFSLALDGLGKRTAAAVSA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 491949015 380 LAynLASIIGATIAAMISLKINASFGVMGVGIYLAI-NALMTFLALLASKETKN 432
Cdd:COG0738 339 VL--IMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVcYLLILLLALALKRKRRK 390
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
68-438 |
3.58e-06 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 48.89 E-value: 3.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAqigiwapiLLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLfvangtffLVSYLLGHN-ALVEWAWRIPFVSSI---LLVAVGLYVrltLHESHVFVEaeqkgkk 223
Cdd:cd17362 126 RGLLVSLKELFIVLGI--------LLGYVSGYAfADVVGGWRYMYGLAAppaLLLGIGMWF---LPPSPRWQG------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 224 lnapvrvvftKHLKPMIIGTFIMvatysLFYIMTAFAQAYSRTAPKLSEAGYAlglgiPANTFTGFLLISAIVFGIFISI 303
Cdd:cd17362 188 ----------NYRKPLIIGLGLV-----LFQQITGQPSVLYYAATIFKSAGFS-----AASDATLVSVGLGVFKLLMTIV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 304 SGFYADKIGRRKWLIwvtiaIGVLGLAMPLFL-----------ENGTPVSVFAFLVIGMAIMGMTFGPMAAL-LPELFPT 371
Cdd:cd17362 248 AVLLVDKLGRRPLLL-----GGVSGMVVSLFLlaaynlfvqmgPAGLAWLSLVALLLYVGAYQISFGPISWLmVSEIFPL 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491949015 372 EVRYSGASlaynLASIIGATIAAMISLKINASFGVMGVGIYLAINALMTFLAL----LASKETKNVDLTEI 438
Cdd:cd17362 323 RVRGRAIA----LAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALlfiyFTVPETKGLSLEEI 389
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
285-422 |
9.48e-06 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 47.50 E-value: 9.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 285 TFTGFLLISAIVFGIFIsisGFYADKIGRRKWLIW---VTIAIGVLGLA-MPLFLENGTPVSVFAFLVIGMAIMGmtFGP 360
Cdd:cd17337 248 QIWGIIFLVNIFFNLIF---GILGDKIGWRRTVRWfggVGCAISTLLFYyVPQLFGHNYWAALIAAILFGIGLAG--FVP 322
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491949015 361 MAALLPELFPTEvrySGASLA-YNLASIIGATIAAMISLKINASFGVMGV-----GIYLAINALMTFL 422
Cdd:cd17337 323 LSALMPSLAPEH---KGAAMSiLNLGAGLSNFVGPAIVTLFLGSFGAGGVvwifaGLYLLSAVLTLFL 387
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
68-404 |
2.31e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.42 E-value: 2.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYaqigiwapILLCVCRVGQGIGLGGEWGGAALVATENAPE-- 145
Cdd:cd17504 46 VSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL--------PVLIAGRALQGIGGAVFPLAFALVREEFPPErv 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 146 -GKRAWYGTFPQLGAPIGLFVAngtfflvSYLLGHnalveWAWRIPFVSSILLVAVGLYvrltlheshvfveaeqkgkkL 224
Cdd:cd17504 118 pVAQGILSATFGIGAGIGLPLG-------GWIVQH-----LGWRWIFWTAAPVAVLLAA--------------------L 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 225 NAPVRVVFTKH---LKPMIIGTFIMVATYSLFYIMTAFAQaysrtapklSEAGYALGLGIpanTFTGFLLISAIVFGIFI 301
Cdd:cd17504 166 VPLIDLRLLRRrnvLLANITALLAGFGMFMVFQLLPQLLQ---------LPTPTGFGLGI---TEAGLLLLPGALVMLIA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 302 S-ISGFYADKIGRRkWLIWVTIAIGVLGLAMPLFLeNGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEvRYSGASL 380
Cdd:cd17504 234 GpLAGRLIARVGPR-RVLLIGLVISAVGLLLLALL-HSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPD-RTGIATG 310
|
330 340
....*....|....*....|....
gi 491949015 381 AYNLASIIGATIAAMISLKINASF 404
Cdd:cd17504 311 MNTVLRTIGSAIGPAIAGAILTTY 334
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
68-432 |
1.00e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 44.56 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLlpnyaQIGIWAPILLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17357 64 IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFL-----SKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSEL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVanGTFFLVSYLLGHNALvewaWRIPFVSSILLVAVGLYVRLTLHES---------------- 211
Cdd:cd17357 139 RGALGSLTQIGVTLGILL--GQVFGLPSVLGTETL----WPYLLFFPGIPALLQLAALPFFPESpkflliskgdeeeaek 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 212 -----------------HVFVEAEQKGKKLNAPVRVVFTKHL--KPMIIGTFIMVAT-----YSLFYIMTAFaqaysrta 267
Cdd:cd17357 213 slkflrgieddvdqeleEIKKESEQMGDQKQVSLMQLLRDPSlrLPLLLVLVVSASQqfsgiNAIFFYSTFI-------- 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 268 pkLSEAGYALGLGIPANTFTGFLLISAIVFGIFIsisgfyADKIGRRKWLIWVTIAIGVLGLAMPLFLENGTPVSVFAFL 347
Cdd:cd17357 285 --FENAGFSPQLAEWANLGIGIVNVLSTIVGPFL------IEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYG 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 348 VIGMAIM-GMTF----GPMAALLP-ELFPTEVRYSGASLAYnLASIIGATIAAMISL---KINASFGVMGVGIYLAINAL 418
Cdd:cd17357 357 CIVAIFLfIFFFaiglGPIPWFIGaELFPQAPRSAAQSLGS-SVNWTSNFIVGMAFPplqSIGGGFVFIIFAIPCALFLL 435
|
410
....*....|....
gi 491949015 419 MTFLALlasKETKN 432
Cdd:cd17357 436 YLYRYL---PETKG 446
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
289-426 |
1.11e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 289 FLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLGLAMP-LFLENGTPVSVFAFLVIGMAIMGMTFGP-MAALLP 366
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLAlLALLGSLSLWLLLVLAFLLGIASAFFGPaRQALLP 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491949015 367 ELFPTEVRYSGASL---AYNLASIIGATIAAMIslkinasFGVMGVGIYLAINALMTFLALLA 426
Cdd:cd06173 119 ELVPKEQLVRANALnslATQLARIIGPALGGLL-------VALLGPGGAFAINALSFLLSALL 174
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
68-426 |
1.14e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 44.10 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQigiwapilLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17320 49 LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ--------LLIARFLQGLGAAAGSVVARAIVRDLYSGAE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAwyGTFPQLGAPIGLFvangtfFLVSYLLGHNALVEWAWRIPFV-----SSILLVAVGLYVRLTLHEshvfveaeQKGK 222
Cdd:cd17320 121 LA--KIFSLLMMILAIA------PALAPLLGGLLLLFFGWRAIFVflallGLLLLLLVLLFLPETLPE--------EKRK 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 223 KLNAPVRVVFTKHLK--PMIIGTFIMVATYSLFYimtafaqAYSRTAPKLseagYALGLGIPANTFTGFLLISAIVFGIF 300
Cdd:cd17320 185 PLLSSLLRAYKRVLKnrRFLGYALALGLSFAGLF-------AYLAAAPFI----YIEQLGLSPAQFGLLFALNAIALILG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 301 ISISGFYADKIGRRKWLIWVTIAIGVLGLAMPL--FLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPtEVRYSGA 378
Cdd:cd17320 254 SLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLaaLLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-HVAGTAS 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 491949015 379 SLAYNLASIIGATIAAMISLKINASFGVMGVGIylainALMTFLALLA 426
Cdd:cd17320 333 ALLGFLQFLIGALAGALVGLLPNGTALPMGLLI-----LVLGLLALLL 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
252-424 |
1.51e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.81 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 252 LFYIMTAFAQAYSRTAPKLSEAGYALGLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLGLAM 331
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 332 PLFlenGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVR---YSGASLAYNLASIIGATIAAMISLKINASFGVMG 408
Cdd:COG2814 93 ALA---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRgraLGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170
....*....|....*.
gi 491949015 409 VGIYLAINALMTFLAL 424
Cdd:COG2814 170 NAVLALLALLLLLRLL 185
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
136-425 |
1.75e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 136 ALVATENAPEGKRAWYG---TFPQLGAPIGLFVAngtFFLVSYLLGHNALVEWAWRIPfvsSILLVAVGLYVRLTLHESH 212
Cdd:cd17370 111 ALLADATPPSGRGKAFGlhrALDTLGAVLGPLLA---ALLLYLLGGNYRTIFLLAAIP---ALLALLILLFVVKEYPRPP 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 213 VFVEAEQKGKKLNAPvrvvftKHLKPMIIGTFIMVATYSLFYIMTAFAQAysrtapklseagyalgLGIPANTFTGFLLI 292
Cdd:cd17370 185 KLRKKSKKTSLKKLP------KAFWLYLLAVALFALGNFSFAFLILRAQE----------------LGLSAALIPLLYAL 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 293 SAIVFGIFISISGFYADKIGRRKwLIWVTIAIGVLGLAMpLFLENGTPVSVFAFLVIGMAiMGMTFGPMAALLPELFPTE 372
Cdd:cd17370 243 FNLVYALAAYPAGRLSDRIGRKK-LLILGYLSLALAYLG-FALGSSLWLLLLGFILWGLY-MGAQESIERAAVADLVPAE 319
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 491949015 373 VRYSG---ASLAYNLASIIGATIAAMISLKINASFGVmgvgIYLAINALMTFLALL 425
Cdd:cd17370 320 LRGTAyglFNTVVGIGWLLASLIAGYLWDLISPSAAF----LFSAVLALIALLLLL 371
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
68-438 |
2.24e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 43.16 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLV-ASLVLMGGStVVIGLLPNYAqigiwapiLLCVCRVGQGIGLGGEWGGAALVATENAPEG 146
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIAlAALIFFVGA-LLMGVAPNYP--------VLMVGRFVAGIGVGFALMIAPVYTAEVAPAS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 147 KRAWYGTFPQLGAPIGLFVAngtfFLVSYLLGhNALVEWAWRipfvssiLLVAVGLYVRLTLhesHVFVEAEQKGKKLNA 226
Cdd:cd17437 118 SRGFLTSFPEIFINIGILLG----YVSNYAFS-GLPLHVGWR-------LMLGVGAVPSLFL---AIGVLAMPESPRWTP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 227 PVRVVftkhlkpMIIGTFIMVATYS------LFYIMTAFAQAYSRTAPKLSEAGYALGLgipanTFTGFLLISAivfgif 300
Cdd:cd17437 183 AVRRM-------LIAALGIHFFQQAsgidavVLYSPRIFKKAGIKSKDKLLLATVAVGV-----TKTLFILVAT------ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 301 isisgFYADKIGRRKWL----IWVTIAIGVLGLAMpLFLENGTPVSVFAFLVIGMAIMG------MTFGPMAALL-PELF 369
Cdd:cd17437 245 -----FLLDKVGRRPLLltstGGMTLSLTALATSL-TFIDRNGGGLTWALVLAITAVCSfvaffsIGAGPITWVYsSEIF 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 370 PTEVRYSGASLAYNLASIIGATIaAMISLKINASFGVMGVGIYLA-INALMTFLALLASKETKNVDLTEI 438
Cdd:cd17437 319 PLRLRAQGASLGVVVNRLMSGTV-SMTFLSMSKAITTGGTFFLFAgVAAAAWVFFYFFLPETKGKSLEEI 387
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
275-429 |
2.34e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 2.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 275 YALGLGIPANTFTGFLLISAIVFGIFISISGFYAD----KIGRRK-WLIWVTIAIGVLGLAM---PLFLENGTPVSVFAF 346
Cdd:COG2211 37 YTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRpWILIGAIPLALSFVLLftaPDLSPTGKLIYALVT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 347 LVIGMAIMGMTFGPMAALLPELFPTE--------VRYSGASLAYNLASIIGATIAAMISLKINASFGVMGVgIYLAINAL 418
Cdd:COG2211 117 YLLLGLAYTLVNIPYSALGAELTPDYeertrlssWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTAL-IFAVLGLL 195
|
170
....*....|.
gi 491949015 419 MTFLALLASKE 429
Cdd:COG2211 196 AFLLTFFGTKE 206
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
68-425 |
4.04e-04 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 42.26 E-value: 4.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQIGIWApiLLCVCRVGQGIGLGGEWGGAALVATENAPEGK 147
Cdd:cd17364 54 IGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKR 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 R----AWYGTFPQLGAPIGLFVANGTF--FLVSYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLheshvfveaeqkg 221
Cdd:cd17364 132 RgaliAAVFAMQGFGILAGAIVTLILSaiFEHPLPAGTYHHADLVWRIVLGLGAIPALSVLYFRKHL------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 222 kklnapvrvvftkhlkpmiIGTFIMVATYSLFYIMTAFAQAYSRTAPKLSEAGYALGLGIPANTFTGFLLISAIVFGIFI 301
Cdd:cd17364 199 -------------------LGTAGTWFLLDIAFYGQNLFQSTIISAIGFSKTMNAYQELFNIAVGQLIIALAGTVPGYWF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 302 SIsgFYADKIGRRKWLIWVTIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMTFGP--MAALLP-ELFPTEVRysga 378
Cdd:cd17364 260 TV--FLIDRIGRKKIQMMGFFGMTIFLLILAGPYDHWKISTIGFFVLYGLTFFFSNFGPntTTFIVPaEVFPARVR---- 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 491949015 379 SLAYNLASIIGATIAAMISLKINASFGVMGVGIYLAINALMTFLALL 425
Cdd:cd17364 334 STCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGII 380
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
72-427 |
4.63e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.16 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 72 LFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNyaqigiwaPILLCVCRVGQGIGLGGEWGGAALVATENAPEGKR--- 148
Cdd:cd17321 50 LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRgra 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 149 -AWYGTFPQLGAPIGLFVAngtfflvsyllghNALVEWA-WRIPFVSSILLVAVGLYVrltlheSHVFVEAeqkgkklna 226
Cdd:cd17321 122 lGLWGAVVGIGAALGPLLG-------------GLLLELFgWRWIFLINVPIGLVALLL------ARTFSGA--------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 227 pvrvvftkhlkpMIIGTFIMVATYSLFYIMTAFAQaysrtapklseagyaLGLGIPANTFTGFLLISAIVFGIFISISGF 306
Cdd:cd17321 174 ------------VLAAFLLGAALGGLLFLLPLYLQ---------------GVLGYSPLQAGLALLPLALAMLVAAPLAGR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 307 YADKIGRRKWLIWVTIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASL---AYN 383
Cdd:cd17321 227 LADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGIlntARQ 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 384 LASIIGATIAAMI----------------SLKINASFGVMGVGIYLAINALMTFLALLAS 427
Cdd:cd17321 307 LGGALGVALLGALltaglsanlgdsgvaaLLSAAAAAFAAGFHLAFLVAAALALLAALLA 366
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
68-414 |
4.87e-04 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 41.96 E-value: 4.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGD-KIGRKKTLVASLVLMGGSTVVIGLLPNYaqigiWAPILLcvcRVGQGIGLGGEWGGAALVATENAPEG 146
Cdd:cd17378 48 IGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNY-----WVYAFL---RFLTGFGRSGIGTCALVLATEPVGPK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 147 KRAWYGTFPQLGAPIGLFVANGTFFLVSYllghnalvewAWRIP-FVSSILLVAVGLYVRLTlheshvfveaeqkgkkln 225
Cdd:cd17378 120 WRGQVGMSTFFFFVLGFMSLPGIAYLNGS----------SWRVLyFWTSIPALIYCILVYLF------------------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 226 aPVRVVFTkhlkpMIIGTFIMVATYslfyimtafaqaysrtapklseaGYALGLG-IPANTFTGFLLISAIVFGIFIsIS 304
Cdd:cd17378 172 -ARRLLAV-----MVIGFGIGMVYY-----------------------GIPLAVGnLKFNIYLSVALNALSELPAFV-IT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 305 GFYADKIGRRKWLIWVTIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELFPTEVRYSGASLAyNL 384
Cdd:cd17378 222 AFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGML-RQ 300
|
330 340 350
....*....|....*....|....*....|....
gi 491949015 385 ASIIGATIAAMISL--KINA--SFGVMGVGIYLA 414
Cdd:cd17378 301 ALVVGGIFAPFIVSlgRKNAalSFGVFGVAILLL 334
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
63-423 |
5.52e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 5.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 63 FFARPIGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQIGIWAPILLCVCRvgqgiglggewggaALVATEN 142
Cdd:cd06173 44 FLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLL--------------GIASAFF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 143 APegkrAWYGTFPQLGAPIGLFVANG-------TFFLVSYLLGHNALVEWAWRIPFVSSILLVAVGLYVRLTLHESHVFV 215
Cdd:cd06173 110 GP----ARQALLPELVPKEQLVRANAlnslatqLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 216 EAEQKGKKLNAPVRVVFTKHLKPMIIGTFIMVATYSLFYIM-TAFAQAYSRTAPKLSEAGYALGLGIPAntftgfllISA 294
Cdd:cd06173 186 PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGAlTVLLPLLAKEVLGGGAAGYGLLLAAFG--------VGA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 295 IVFGIFISIsgfyadKIGRRKWLIWVTIAIGVLGLAMPLF-LENGTPVSVFAFLVIGMAiMGMTFGPMAALLPELFPTEV 373
Cdd:cd06173 258 LLGALLLGR------LSKRRRRGRLLLIGALLLGLALLVLgLSPSLWLLLAALFLLGLA-GGLFNVPLNTLLQLRVPDEL 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 491949015 374 R---YSGASLAYNLASIIGATIAAMISLKINASFGVMGVGIYLAINALMTFLA 423
Cdd:cd06173 331 RgrvFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
279-422 |
8.75e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.44 E-value: 8.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 279 LGIPANTFTGFLLISAIVFGIFISISGFYADKI-----GRRKWLIWVTIAIGVLGLAM---PLFLENGTPVSVFAFLVIG 350
Cdd:cd17332 30 LGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIPLALLFVLLfttPDGSGTGKLIYALITYILL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 351 MAIMGMTFGPMAALLPELFP--------TEVRYSGASLAYNLASIIGATIAAMISlKINASFGVMGVGIYLAINALMTFL 422
Cdd:cd17332 110 DLLYTLVNIPYTALIPELTDdpeertslTSWRMFFATIGGLLVTVLPPPLVAYFG-GGNASRGYFLTALIIGIIGIILLL 188
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
276-381 |
1.30e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 40.70 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 276 ALGLGIPANTFTGFLLISAIVFGIFISIsgFYADKIGRRKWLIW---------VTIAIgVLGLAMPL--FLENGTPVSVF 344
Cdd:cd17361 229 TLGFGSDASLISAVITGAVNVVSTLVSI--YLVDRFGRRFLLLEggvqmlasqVAIGI-LLAVKFGDggELPKAYAIAVV 305
|
90 100 110
....*....|....*....|....*....|....*...
gi 491949015 345 AFLVIGMAIMGMTFGPMAALLP-ELFPTEVRYSGASLA 381
Cdd:cd17361 306 VLICLYVAAFAWSWGPLGWLVPsEIFPLETRSAGQSLT 343
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
67-437 |
1.57e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 40.64 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 67 PIGSALFGHFGDKIGRKKTLVASLVLmggstVVIGLLPNYAQIGIWapiLLCVCRVGQGIGLGGEWGGAALVATENAPEG 146
Cdd:cd17358 55 LIGALLSGKLADRIGRKRTLLISAIP-----CILGWLLIAFAKDVW---MLYLGRFLAGFGGGAASVVVPVYIAEIAPKN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 147 KRAWYGTFPQLGAPIGLfvangtffLVSYLLGhnALVEWAWrIPFVSSILLVAVGLYVrLTLHESHVFV-------EAEQ 219
Cdd:cd17358 127 VRGALGSLNQLLVNIGI--------LLGYVLG--SFLPWRT-LALIGAIPPVVFLILL-FFIPESPRWLakkgreeEAEK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 220 -----KGKK-----------------LNAPVRVVFT-----KHLKPMIIGTFIMV------ATYSLFYIMTAFAQAysrt 266
Cdd:cd17358 195 slqflRGKDadiskeaaeiqeelaelEKEAKESSFSdlfqrKYLKPLVIGLGLMLfqqlsgINAVIFYASSIFDEA---- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 267 apklseagyalGLGIPANTFTgflLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLGLAMPLF--------LENG 338
Cdd:cd17358 271 -----------GSGLDPNTAT---IIIGVVQVVGTLVATLLVDRLGRRPLLLVSAIGMGIGLLALGLYfylqehgaLLSS 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 339 TPVSVFAFLVIGMAIMGMTFGPMAAL-LPELFPTEVRYSGASLAyNLASIIGATIAAMISLKINASFGVMGV-GIYLAIN 416
Cdd:cd17358 337 VSWLPLVGLVIYIISFSIGLGPLPWViMSEIFPAKIKGLAGSLV-TLVNWLFAFIVTKTFPFLTLAWGASGTfWIFAGIC 415
|
410 420
....*....|....*....|.
gi 491949015 417 ALMTFLALLASKETKNVDLTE 437
Cdd:cd17358 416 GLALVFVLLFVPETKGKSLEE 436
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
297-396 |
2.39e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 40.29 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 297 FGIFISISGFYADKIGRRKWLIWVTIAIGVLGLAMPLFLENGTPVSVFAFLVIgMAIMGMTFGPM-AALLPELFPTEvRY 375
Cdd:PRK08633 60 FLLLSSPAGFLADKFSKNRVIRIVKLFEVGLTLLIVLAYYLGWFWLAFAVTFL-LGAQSAIYSPAkYGIIPELVGKE-NL 137
|
90 100
....*....|....*....|.
gi 491949015 376 SGASLAYNLASIIgATIAAMI 396
Cdd:PRK08633 138 SRANGLLEAFTIV-AILAGTA 157
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
148-415 |
2.56e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.90 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTFPQLGAPIGLFVANGTF-FLVSYLLGHNALVEWAWRIPFVSSILLVAVgLYVRLTLHESHVFVEAEQKGKKLNA 226
Cdd:cd17332 134 RTSLTSWRMFFATIGGLLVTVLPpPLVAYFGGGNASRGYFLTALIIGIIGIILL-LICFFGTRERVVPPEEEKSKLPLLK 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 227 PVRVVFT--KHLKPMIIGTFIMVATYSLFYIMTAFAQaysrtapklseagYALGlgiPANTFTGFLLISAIVFGIFISIS 304
Cdd:cd17332 213 SLKALLKnrPFLILLLAYLLYFLAFNIVNTVLVYYFK-------------YVLG---GRAELVLLLLLILSGALLALLPW 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 305 GFYADKIGRrKWLIWVTIAIGVLGLAMPLFLENGTPVSVFAFLVIGMAIMGMTFGPMAALLPELfpteVRYSGASLAYNL 384
Cdd:cd17332 277 PPLKKRFGK-KKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADV----IDYGELKTGKRR 351
|
250 260 270
....*....|....*....|....*....|.
gi 491949015 385 ASIIGATIaaMISLKINASFGVMGVGIYLAI 415
Cdd:cd17332 352 EGIFYSVM--TFFRKLGLALAGALVGLILSL 380
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
279-425 |
3.18e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.32 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 279 LGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLIWVTIAIGVLGLAmpLFLENGTPVSVFAFLVIGMAiMGMTF 358
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL--LLFASSLWLLLVLRVLQGLG-AGALF 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 491949015 359 GPMAALLPELFPTEVRYSGASLaYNLASIIGATIAAMISLKINASFGVMGVGIYLAINALMTFLALL 425
Cdd:pfam07690 104 PAALALIADWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL 169
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
63-425 |
3.60e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 3.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 63 FFARPIGSALfghfGDKIGRKKTLVASLVLMGGSTVVIGLLPNyaqigiwaPILLCVCRVGQGIGLGGEWGGAALVATEN 142
Cdd:cd17489 45 LLARPFAGRL----LDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFTTAAATLVADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 143 APEGKRA----WYGTFPQLGAPIGLFVAngtfflvSYLLGHnalveWAWRIPFVSSILLVAVGLYVRLTLHESHVFVEAE 218
Cdd:cd17489 113 IPPSRRGegigYYGLATTLAMALGPALG-------LFLYQH-----LGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 219 QKGKKLNAPVRVVftkhLKPMIIGTFIMVATYSLFYIMTaFAQAYSRTAPkLSEAGYalglgipantftgFLLISAIVFG 298
Cdd:cd17489 181 AEAGTRAFRRLVE----KKVLPPALILFLASIAYGAIST-FLPLYAAERG-ISNAGL-------------FFTVYAIALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 299 IFISISGFYADKIGrRKWLIWVTIAIGVLGLAMpLFLENGTPVSVFAFLVIGMAiMGMTFGPMAALLPELFPTEVRYSGA 378
Cdd:cd17489 242 LSRPFSGKLSDRKG-PKTVIIPGLLLLALGLLL-LSFAGSPWMLLLAAVLYGLG-FGLLFPALQALAVDLVPPHRRGAAN 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 491949015 379 SL---AYNLASIIGATIAAMISlkinasfGVMGVGIYLAINALMTFLALL 425
Cdd:cd17489 319 GTffiFFDLGIGLGGLLLGLVA-------ELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
287-426 |
6.33e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.71 E-value: 6.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 287 TGFLLISAIVFGIFISI-SGFYADKI--GRRKWLIWVTIAIGVLGLAMPLFLENgtPVSVFAFLVIGMAIMGMTFGPMAA 363
Cdd:cd17319 217 VGLLAAIPFLAGAIGMIlGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTS--PVVAVILLSLAGFGIGAASPVFWS 294
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491949015 364 LLPELFPTEVRYSGASLAYNLASIIGATIAAMISLKINASFGVMGVGIYLAINALMTFLALLA 426
Cdd:cd17319 295 LPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
170-426 |
6.35e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 38.76 E-value: 6.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 170 FFLVSYLLGHNALVEWAW---RIPF-VSSILLVAVGLYVRLTLHESHVFVEAEQKGK-----KLNAPVRVVFTKHLKPMI 240
Cdd:cd17313 158 YLLGAILWDHNWFGFALGgnlKVPFyIGAIILLVCVLVTLFFVKEPPLSPEAGEHSEnpslgEVLKSLLKLLKIMPRSLL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 241 IGTFIMVATYSLFYIMTAFAQAYSRTAPKLSEAGYALGLGIPANTFTGFLLISAIVFGIFISISGFYADKIGRRKWLIwV 320
Cdd:cd17313 238 RLLLVIFFWWIAFFPFELFFTDYMGEEVYHGTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYL-I 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 321 TIAIGVLGLAMPLFLENgtpvsVFAFLVIgMAIMGMTFGPMA----ALLPELFPTEVRYSGASLA-YNLASIIGATIAAm 395
Cdd:cd17313 317 GLVLFAVGMALMALVHN-----VTVALVL-FALGGIGWATINinpyPLVSDYHSESGRGQGTDTGlLNLAISLAQILVS- 389
|
250 260 270
....*....|....*....|....*....|.
gi 491949015 396 islkiNASFGVMGVGIYLAINALMTFLALLA 426
Cdd:cd17313 390 -----LLAGPIIDVKGYGTVFPVAAVASFLS 415
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
68-428 |
7.30e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 38.32 E-value: 7.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 68 IGSALFGHFGDKIGRKKTLVASLVLMGGSTVVIGLLPNYAQIGIWAPILLCVCRVGQGIGlggewggAALVatenapegk 147
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLL-------PGLI--------- 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 148 RAWYGTfpQLGAPIGLF-VANGTFFLVSYLLGHNALVEWAWRIPFVSSILLVAVGLYV-RLTLHESHVFVEAEQKGKKLN 225
Cdd:COG2807 132 KRWFPD--RVGLMTGLYtAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLwLPLLRRRPAAAAAAPAAASLR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 226 APVRVVFTKHLkpmiigTFIMVATYSLFYIMTAFAQAYsrtapkLSEAGYALGLgipANTFTGFLLISAIVFGIFIsisG 305
Cdd:COG2807 210 SLWRSPLAWLL------TLFFGLQSLLYYAVVAWLPPI------LRDAGLSAAT---AGLLLSLFQLAGIPGSLLV---P 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491949015 306 FYADKIGRRKWLIWVTIAIGVLGLAMPLFLenGTPVSVFAFLVIGMAiMGMTFGPMAALLPELFPTEVRYSGASLAYNLA 385
Cdd:COG2807 272 LLADRLGDRRPLLLLLGLLGLAGLLGLLLA--PGSLPWLWAVLLGLG-QGGLFPLALTLIGLRARTPAEAAALSGMAQSV 348
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 491949015 386 SIIGATIAAMISLKINASFG--VMGVGIYLAINALMTFLALLASK 428
Cdd:COG2807 349 GYLLAALGPLLVGALHDATGswTAALLLLAALAVLMLVAGLLAGR 393
|
|
| |
