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Conserved domains on  [gi|491995432|ref|WP_005711963|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Pasteurellaceae]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 229396)

helix-turn-helix domain-containing protein may bind DNA and be involved in the regulation of gene expression

Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARSR super family cl46857
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-37 3.99e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


The actual alignment was detected with superfamily member cd00090:

Pssm-ID: 481197 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 3.99e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 491995432  5 EIYQALKRKNLNASMIAEALGVSSQAVSSAIKQ 37
Cdd:cd00090  11 RILRLLLEGPLTVSELAERLGLSQSTVSRHLKK 43
PriA super family cl43353
Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, ...
 3-85 1.79e-03

Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG1198:

Pssm-ID: 440811 [Multi-domain]  Cd Length: 728  Bit Score: 35.48  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491995432   3 QKEIYQALKRKN--LNASMIAEALGVSSQAVSSAIKQG--KSSQRIAKAIAIAIDEPLEKvfPHYAKKEQKQVFrsNQIA 78
Cdd:COG1198  133 QRRVLEALREHGgpLTLSELAKEAGVSRSVLKALVKKGllEIEEREVDRDPFAPDVPAEP--PPTLNEEQQAAV--EAIR 208


                 ....*..
gi 491995432  79 HLKNQFS 85
Cdd:COG1198  209 AAAGGFS 215
 
Name Accession Description Interval E-value
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-37 3.99e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 3.99e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 491995432  5 EIYQALKRKNLNASMIAEALGVSSQAVSSAIKQ 37
Cdd:cd00090  11 RILRLLLEGPLTVSELAERLGLSQSTVSRHLKK 43
MJ0558 COG1497
Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain [Transcription];
5-37 1.39e-03

Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain [Transcription];


Pssm-ID: 441106  Cd Length: 261  Bit Score: 35.60  E-value: 1.39e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 491995432   5 EIyqALKRKNLNASMIAEALGVSSQAVSSAIKQ 37
Cdd:COG1497   18 EI--AERQPAVRQGEIADKLGVTPQAVSEYIKE 48
PriA COG1198
Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, ...
 3-85 1.79e-03

Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440811 [Multi-domain]  Cd Length: 728  Bit Score: 35.48  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491995432   3 QKEIYQALKRKN--LNASMIAEALGVSSQAVSSAIKQG--KSSQRIAKAIAIAIDEPLEKvfPHYAKKEQKQVFrsNQIA 78
Cdd:COG1198  133 QRRVLEALREHGgpLTLSELAKEAGVSRSVLKALVKKGllEIEEREVDRDPFAPDVPAEP--PPTLNEEQQAAV--EAIR 208


                 ....*..
gi 491995432  79 HLKNQFS 85
Cdd:COG1198  209 AAAGGFS 215
 
Name Accession Description Interval E-value
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 5-37 3.99e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 35.35  E-value: 3.99e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 491995432  5 EIYQALKRKNLNASMIAEALGVSSQAVSSAIKQ 37
Cdd:cd00090  11 RILRLLLEGPLTVSELAERLGLSQSTVSRHLKK 43
MJ0558 COG1497
Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain [Transcription];
5-37 1.39e-03

Predicted transcriptional regulator MJ0558, contains a CRP-type HTH domain [Transcription];


Pssm-ID: 441106  Cd Length: 261  Bit Score: 35.60  E-value: 1.39e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 491995432   5 EIyqALKRKNLNASMIAEALGVSSQAVSSAIKQ 37
Cdd:COG1497   18 EI--AERQPAVRQGEIADKLGVTPQAVSEYIKE 48
PriA COG1198
Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, ...
 3-85 1.79e-03

Primosomal protein N' (replication factor Y) - superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440811 [Multi-domain]  Cd Length: 728  Bit Score: 35.48  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491995432   3 QKEIYQALKRKN--LNASMIAEALGVSSQAVSSAIKQG--KSSQRIAKAIAIAIDEPLEKvfPHYAKKEQKQVFrsNQIA 78
Cdd:COG1198  133 QRRVLEALREHGgpLTLSELAKEAGVSRSVLKALVKKGllEIEEREVDRDPFAPDVPAEP--PPTLNEEQQAAV--EAIR 208


                 ....*..
gi 491995432  79 HLKNQFS 85
Cdd:COG1198  209 AAAGGFS 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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