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Conserved domains on  [gi|492022039|ref|WP_005721098|]
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MULTISPECIES: cyclic di-AMP binding protein CbpA [Lactobacillus]

Protein Classification

CBS domain-containing protein( domain architecture ID 17609527)

CBS (cystathione beta synthase) domain-containing protein; CBS domains may act as regulatory units

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CBS_CbpA NF038387
cyclic di-AMP binding protein CbpA; The founding member of this family, Lmo0553 from Listeria ...
 1-213 3.91e-140

cyclic di-AMP binding protein CbpA; The founding member of this family, Lmo0553 from Listeria monocytogenes, now called CbpA, binds cyclic di-AMP, a signaling molecule, through its CBS (cystathionine-beta-synthase ) domain.


:

Pssm-ID: 439679  Cd Length: 209  Bit Score: 390.83  E-value: 3.91e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039   1 MLIKSLVIKKDYLTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTIFRGNIYKMHIYRHKSQGGDMNLPVTYLLKNATKT 80
Cdd:NF038387   1 MLLKSLVKPKEDLTTVKEDATLEEALKILEDSGYRCVPILDETGKIFRGNIYKMHIYRHKSRGGDMSLPVTHLLKNATKF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039  81 IKVNSPFFKVFFNIKDLPYIAVLDEDNHFYGILTHSRMLDMLSDAWDVKNGSYVLTVLSDNTRGNLIKMSKIVSKHTNMS 160
Cdd:NF038387  81 ISVNSSFFKVFFTIKDLPYIAVLDENNHFYGILTHSSLLNMLSQSWNVNTGSYVLTVASSGERGDLAKMAKIITKYTSIA 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 492022039 161 SVMTLDaaagELEGNFVRRTLFTLPAGVSDITMRTIVDKLQRKGFVVSEIEDL 213
Cdd:NF038387 161 SCITLD----EQSDELVRRTLFTLPAGVDEETLDKIVSRLERKGFRVVEIEDL 209
 
Name Accession Description Interval E-value
CBS_CbpA NF038387
cyclic di-AMP binding protein CbpA; The founding member of this family, Lmo0553 from Listeria ...
 1-213 3.91e-140

cyclic di-AMP binding protein CbpA; The founding member of this family, Lmo0553 from Listeria monocytogenes, now called CbpA, binds cyclic di-AMP, a signaling molecule, through its CBS (cystathionine-beta-synthase ) domain.


Pssm-ID: 439679  Cd Length: 209  Bit Score: 390.83  E-value: 3.91e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039   1 MLIKSLVIKKDYLTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTIFRGNIYKMHIYRHKSQGGDMNLPVTYLLKNATKT 80
Cdd:NF038387   1 MLLKSLVKPKEDLTTVKEDATLEEALKILEDSGYRCVPILDETGKIFRGNIYKMHIYRHKSRGGDMSLPVTHLLKNATKF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039  81 IKVNSPFFKVFFNIKDLPYIAVLDEDNHFYGILTHSRMLDMLSDAWDVKNGSYVLTVLSDNTRGNLIKMSKIVSKHTNMS 160
Cdd:NF038387  81 ISVNSSFFKVFFTIKDLPYIAVLDENNHFYGILTHSSLLNMLSQSWNVNTGSYVLTVASSGERGDLAKMAKIITKYTSIA 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 492022039 161 SVMTLDaaagELEGNFVRRTLFTLPAGVSDITMRTIVDKLQRKGFVVSEIEDL 213
Cdd:NF038387 161 SCITLD----EQSDELVRRTLFTLPAGVDEETLDKIVSRLERKGFRVVEIEDL 209
CBS_pair_SF cd02205
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS ...
 13-120 9.64e-12

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341358 [Multi-domain]  Cd Length: 113  Bit Score: 59.95  E-value: 9.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039  13 LTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTiFRGNIYKMHIYRH-KSQGGDMNLPVTYLLKNATKTIKVNSPFFKVF 91
Cdd:cd02205    4 VVTVDPDTTVREALELMAENGIGALPVVDDDGK-LVGIVTERDILRAlVEGGLALDTPVAEVMTPDVITVSPDTDLEEAL 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 492022039  92 --FNIKDLPYIAVLDEDNHFYGILTHSRMLD 120
Cdd:cd02205   83 elMLEHGIRRLPVVDDDGKLVGIVTRRDILR 113
CBS COG0517
CBS domain [Signal transduction mechanisms];
1-119 1.24e-10

CBS domain [Signal transduction mechanisms];


Pssm-ID: 440283 [Multi-domain]  Cd Length: 128  Bit Score: 57.18  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039   1 MLIKSLVIKKdyLTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTiFRGNIYKMHIYRH-KSQGGD-MNLPVTYLLKNAT 78
Cdd:COG0517    1 MKVKDIMTTD--VVTVSPDATVREALELMSEKRIGGLPVVDEDGK-LVGIVTDRDLRRAlAAEGKDlLDTPVSEVMTRPP 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 492022039  79 KTIKVNSPFFKVF-----FNIKDLPyiaVLDEDNHFYGILTHSRML 119
Cdd:COG0517   78 VTVSPDTSLEEAAelmeeHKIRRLP---VVDDDGRLVGIITIKDLL 120
PRK14869 PRK14869
putative manganese-dependent inorganic diphosphatase;
5-56 8.32e-04

putative manganese-dependent inorganic diphosphatase;


Pssm-ID: 237843 [Multi-domain]  Cd Length: 546  Bit Score: 40.20  E-value: 8.32e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 492022039   5 SLVIKKDYLTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTiFRGNIYKMHI 56
Cdd:PRK14869 249 SYIMTTEDLVTFSKDDYLEDVKEVMLKSRYRSYPVVDEDGK-VVGVISRYHL 299
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 13-46 1.75e-03

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 35.65  E-value: 1.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 492022039   13 LTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTI 46
Cdd:pfam00571   9 VVTVSPDTTLEEALELMREHGISRLPVVDEDGKL 42
 
Name Accession Description Interval E-value
CBS_CbpA NF038387
cyclic di-AMP binding protein CbpA; The founding member of this family, Lmo0553 from Listeria ...
 1-213 3.91e-140

cyclic di-AMP binding protein CbpA; The founding member of this family, Lmo0553 from Listeria monocytogenes, now called CbpA, binds cyclic di-AMP, a signaling molecule, through its CBS (cystathionine-beta-synthase ) domain.


Pssm-ID: 439679  Cd Length: 209  Bit Score: 390.83  E-value: 3.91e-140
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039   1 MLIKSLVIKKDYLTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTIFRGNIYKMHIYRHKSQGGDMNLPVTYLLKNATKT 80
Cdd:NF038387   1 MLLKSLVKPKEDLTTVKEDATLEEALKILEDSGYRCVPILDETGKIFRGNIYKMHIYRHKSRGGDMSLPVTHLLKNATKF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039  81 IKVNSPFFKVFFNIKDLPYIAVLDEDNHFYGILTHSRMLDMLSDAWDVKNGSYVLTVLSDNTRGNLIKMSKIVSKHTNMS 160
Cdd:NF038387  81 ISVNSSFFKVFFTIKDLPYIAVLDENNHFYGILTHSSLLNMLSQSWNVNTGSYVLTVASSGERGDLAKMAKIITKYTSIA 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 492022039 161 SVMTLDaaagELEGNFVRRTLFTLPAGVSDITMRTIVDKLQRKGFVVSEIEDL 213
Cdd:NF038387 161 SCITLD----EQSDELVRRTLFTLPAGVDEETLDKIVSRLERKGFRVVEIEDL 209
CBS_pair_SF cd02205
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS ...
 13-120 9.64e-12

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains superfamily; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341358 [Multi-domain]  Cd Length: 113  Bit Score: 59.95  E-value: 9.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039  13 LTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTiFRGNIYKMHIYRH-KSQGGDMNLPVTYLLKNATKTIKVNSPFFKVF 91
Cdd:cd02205    4 VVTVDPDTTVREALELMAENGIGALPVVDDDGK-LVGIVTERDILRAlVEGGLALDTPVAEVMTPDVITVSPDTDLEEAL 82

                         90       100       110
                 ....*....|....*....|....*....|.
gi 492022039  92 --FNIKDLPYIAVLDEDNHFYGILTHSRMLD 120
Cdd:cd02205   83 elMLEHGIRRLPVVDDDGKLVGIVTRRDILR 113
CBS COG0517
CBS domain [Signal transduction mechanisms];
1-119 1.24e-10

CBS domain [Signal transduction mechanisms];


Pssm-ID: 440283 [Multi-domain]  Cd Length: 128  Bit Score: 57.18  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039   1 MLIKSLVIKKdyLTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTiFRGNIYKMHIYRH-KSQGGD-MNLPVTYLLKNAT 78
Cdd:COG0517    1 MKVKDIMTTD--VVTVSPDATVREALELMSEKRIGGLPVVDEDGK-LVGIVTDRDLRRAlAAEGKDlLDTPVSEVMTRPP 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 492022039  79 KTIKVNSPFFKVF-----FNIKDLPyiaVLDEDNHFYGILTHSRML 119
Cdd:COG0517   78 VTVSPDTSLEEAAelmeeHKIRRLP---VVDDDGRLVGIITIKDLL 120
COG3448 COG3448
CBS-domain-containing membrane protein [Signal transduction mechanisms];
1-127 2.35e-10

CBS-domain-containing membrane protein [Signal transduction mechanisms];


Pssm-ID: 442671 [Multi-domain]  Cd Length: 136  Bit Score: 56.80  E-value: 2.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039   1 MLIKSLVIKKdyLTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTiFRGNIYKMHIYRHKSQGG-------DMNLPVTYL 73
Cdd:COG3448    2 MTVRDIMTRD--VVTVSPDTTLREALELMREHGIRGLPVVDEDGR-LVGIVTERDLLRALLPDRldeleerLLDLPVEDV 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 492022039  74 LKNATKTIKVNSPFFKVF--FNIKDLPYIAVLDEDNHFYGILTHSRMLDMLSDAWD 127
Cdd:COG3448   79 MTRPVVTVTPDTPLEEAAelMLEHGIHRLPVVDDDGRLVGIVTRTDLLRALARLLE 134
COG2524 COG2524
Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];
1-122 6.31e-08

Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription];


Pssm-ID: 442013 [Multi-domain]  Cd Length: 206  Bit Score: 51.42  E-value: 6.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039   1 MLIKSLVIKKdyLTTVNEKATLAEALKVLEDSGYRCVPIVDDtgTIFRGNIYKMHIYRHKSQGGD-MNLPVTYLLKNATK 79
Cdd:COG2524   86 MKVKDIMTKD--VITVSPDTTLEEALELMLEKGISGLPVVDD--GKLVGIITERDLLKALAEGRDlLDAPVSDIMTRDVV 161

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 492022039  80 TIKVNSPFFKVF--FNIKDLPYIAVLDEDNHFYGILTHSRMLDML 122
Cdd:COG2524  162 TVSEDDSLEEALrlMLEHGIGRLPVVDDDGKLVGIITRTDILRAL 206
YtoI COG4109
Predicted transcriptional regulator containing CBS domains [Transcription];
1-116 2.24e-04

Predicted transcriptional regulator containing CBS domains [Transcription];


Pssm-ID: 443285 [Multi-domain]  Cd Length: 135  Bit Score: 39.90  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039   1 MLIKSLVIKKDYlTTVNEKATLAEALKVLEDSGYRCVPIVDD----TGTIFRGNIYKMhiyrhksqggDMNLPVTYLLKN 76
Cdd:COG4109   16 LLVEDIMTLEDV-ATLSEDDTVEDALELLEKTGHSRFPVVDEngrlVGIVTSKDILGK----------DDDTPIEDVMTK 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 492022039  77 ATKTIKVNSPFFKVF--FNIKDLPYIAVLDEDNHFYGILTHS 116
Cdd:COG4109   85 NPITVTPDTSLASAAhkMIWEGIELLPVVDDDGRLLGIISRQ 126
PRK14869 PRK14869
putative manganese-dependent inorganic diphosphatase;
5-56 8.32e-04

putative manganese-dependent inorganic diphosphatase;


Pssm-ID: 237843 [Multi-domain]  Cd Length: 546  Bit Score: 40.20  E-value: 8.32e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 492022039   5 SLVIKKDYLTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTiFRGNIYKMHI 56
Cdd:PRK14869 249 SYIMTTEDLVTFSKDDYLEDVKEVMLKSRYRSYPVVDEDGK-VVGVISRYHL 299
CBS_pair_bac cd04643
Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria; ...
 5-119 9.12e-04

Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains present in bacteria; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called Bateman domain or a CBS pair based on crystallographic studies in bacteria. The CBS pair was used as a basis for this cd hierarchy since the human CBS proteins can adopt the typical core structure and form an intramolecular CBS pair. The interface between the two CBS domains forms a cleft that is a potential ligand binding site. The CBS pair coexists with a variety of other functional domains and this has been used to help in its classification here. It has been proposed that the CBS domain may play a regulatory role, although its exact function is unknown. Mutations of conserved residues within this domain are associated with a variety of human hereditary diseases, including congenital myotonia, idiopathic generalized epilepsy, hypercalciuric nephrolithiasis, and classic Bartter syndrome (CLC chloride channel family members), Wolff-Parkinson-White syndrome (gamma 2 subunit of AMP-activated protein kinase), retinitis pigmentosa (IMP dehydrogenase-1), and homocystinuria (cystathionine beta-synthase).


Pssm-ID: 341400 [Multi-domain]  Cd Length: 130  Bit Score: 38.25  E-value: 9.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492022039   5 SLVIKKDYLTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTiFRGNIYKMHI--YRHKSQGGDM----NLPVTYLLKNAT 78
Cdd:cd04643    1 DFLIPAEKVAHVQDTNNLEHALLVLTKSGYSRIPVLDKDYK-LVGLISLSMIldAILGLERIEFeklsELKVEEVMNTDV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 492022039  79 KTIKVNSPFFKVFFNIKDLPYIAVLDEDNHFYGILTHSRML 119
Cdd:cd04643   80 PTVSPDDDLEEVLHLLVDHPFLCVVDEDGYFLGIITRREIL 120
CBS pfam00571
CBS domain; CBS domains are small intracellular modules that pair together to form a stable ...
 13-46 1.75e-03

CBS domain; CBS domains are small intracellular modules that pair together to form a stable globular domain. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet. CBS domain pairs from AMPK bind AMP or ATP. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP.


Pssm-ID: 425756 [Multi-domain]  Cd Length: 57  Bit Score: 35.65  E-value: 1.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 492022039   13 LTTVNEKATLAEALKVLEDSGYRCVPIVDDTGTI 46
Cdd:pfam00571   9 VVTVSPDTTLEEALELMREHGISRLPVVDEDGKL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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