|
Name |
Accession |
Description |
Interval |
E-value |
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
5-467 |
0e+00 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 641.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 5 KESFFNTISFRIFAFFWLTFSLLSILIFSIPYFDSRIYSELSEKEL---SAYQQEIITSIRHNQIARILAGVPLSHA-ER 80
Cdd:PRK09470 2 RLPMINSLTARIFAIFWLTLALVLMLVLMLPKLDSRQMTELLDSEQrqgLMIEQHIEAELANDPPNDLMWWRRLFRAiDK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 81 F--DGIRPVLVDDvdDSSILGATATEIPLLTQFMFSSSDPTRPLKKVFGDVRIVGPFSIHLGgeaNKSYTLYFIDRVN-A 157
Cdd:PRK09470 82 WapPGQRLLLVTS--EGRIIGAERSEMQAVRNFIGQSDNADHPQKKKYGRVEIVGPFSVRDG---EDNYQLYLIRPANsP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 158 QKEIMSFVFANPALLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETkGSLELRQVGQSFNQMTES 237
Cdd:PRK09470 157 QSDFINLLFDRPLLLLLVTMLVSTPLLLWLAWSLAKPARKLKNAADEVAQGNLRQHPELET-GPQEFRQAGASFNQMVTA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 238 LEELLSSQQVLLSSISHELRTPLTRLQLALALLRRRFGEDNtEIHRIEIEARRLDKMINDLLLLSRQQLHSHVSREIFPI 317
Cdd:PRK09470 236 LERMMTSQQRLLSDISHELRTPLTRLQLATALLRRRQGESK-ELERIETEAQRLDSMINDLLVLSRNQQKNHLERETFKA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 318 NELWEEVLDDAIFEAEHRKLNFVVrqnITQPARYYVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDN 397
Cdd:PRK09470 315 NSLWSEVLEDAKFEAEQMGKSLTV---SAPPGPWPINGNPNALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDD 391
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 398 GHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPLWITS 467
Cdd:PRK09470 392 GPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKRS 461
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
97-463 |
3.49e-52 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 180.90 E-value: 3.49e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 97 ILGATATEIPLLTQFMFSSSDPTRPLKKVFGDVRIVGPFSIHLGGEANKSYTLYFIDRVNAQKEIMSFVFANPALLVGLI 176
Cdd:COG5002 21 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 177 ILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLELRQVGQSFNQmtesLEELLSSQQVLLSSISHEL 256
Cdd:COG5002 101 LLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITE----LERLEQMRREFVANVSHEL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 257 RTPLTRLQLALALLRRRFGEDNTE----IHRIEIEARRLDKMINDLLLLSR-QQLHSHVSREIFPINELWEEVLDDAIFE 331
Cdd:COG5002 177 RTPLTSIRGYLELLLDGAADDPEErreyLEIILEEAERLSRLVNDLLDLSRlESGELKLEKEPVDLAELLEEVVEELRPL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 332 AEHRKLNFVVRqniTQPARYYVNGNKALLVSAIENIVRNALKYTQ--SEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKI 409
Cdd:COG5002 257 AEEKGIELELD---LPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPegGTITVSLREEDDQVRISVRDTGIGIPEEDLPRI 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 492029959 410 FQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPL 463
Cdd:COG5002 334 FERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPL 387
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
160-463 |
3.23e-48 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 168.55 E-value: 3.23e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 160 EIMSFVFANPALLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLELRQVGQSFNQMTESLE 239
Cdd:COG0642 25 LLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 240 ELLSSQQVLLSSISHELRTPLTRLQLALALLRRRFGEDNTE-IHRIEIEARRLDKMINDLLLLSR-QQLHSHVSREIFPI 317
Cdd:COG0642 105 EANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREyLETILRSADRLLRLINDLLDLSRlEAGKLELEPEPVDL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 318 NELWEEVLDDAIFEAEHRKLNFVVRqniTQPARYYVNGNKALLVSAIENIVRNALKYTQ--SEIRVSIFLKRQELMIVID 395
Cdd:COG0642 185 AELLEEVVELFRPLAEEKGIELELD---LPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPegGTVTVSVRREGDRVRISVE 261
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492029959 396 DNGHGLDEAEYEKIFQPFYRVDEtrTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPL 463
Cdd:COG0642 262 DTGPGIPPEDLERIFEPFFRTDP--SRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
232-463 |
2.55e-47 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 163.15 E-value: 2.55e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 232 NQMTESLEELLSSQQVLLSSISHELRTPLTRLQLALALLRRRFGEDNTE----IHRIEIEARRLDKMINDLLLLSR-QQL 306
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEErrelLEIIRESAERLLRLIEDLLDLSRlESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 307 HSHVSREIFPINELWEEVLDDAIFEAEHRKLNFVVRqniTQPARYYVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLK 386
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELD---LPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISAR 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492029959 387 RQELMIVID--DNGHGLDEAEYEKIFQPFYRVDetRTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPL 463
Cdd:COG2205 160 REGDGVRISvsDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPL 236
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-463 |
2.26e-40 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 140.15 E-value: 2.26e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 360 LVSAIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVK 439
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|....
gi 492029959 440 EHHGAVWANASQLGGLCVTLCIPL 463
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
170-466 |
1.73e-39 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 147.44 E-value: 1.73e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 170 ALLVGLIILVSTPLLWWLaRSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLElrQVGQSFNQMTESLEELLSSQQVLL 249
Cdd:PRK10604 140 ALLALIGLSLAFPVFLWM-RPHWQDMLKLEAAAQRLGDGHLAERIHFDEGSSLE--RLGVAFNQMADNINALIASKKQLI 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 250 SSISHELRTPLTRLQLALALLRrrfGEDNTEIHRIEIEARRLDKMINDLLL---LSRQQLHSHVSREIFPineLW-EEVL 325
Cdd:PRK10604 217 DGIAHELRTPLVRLRYRLEMSD---NLSAAESQALNRDIGQLEALIEELLTyarLDRPQNELHLSEPDLP---AWlSTHL 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 326 DDAifeaehRKLNFVVRQNITQPAR-YYVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHGLDEA 404
Cdd:PRK10604 291 ADI------QAVTPEKTVRLDTPHQgDYGALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPE 364
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492029959 405 EYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPLWIT 466
Cdd:PRK10604 365 ERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWHN 426
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
158-463 |
1.11e-35 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 136.96 E-value: 1.11e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 158 QKEIMSFVFANpaLLVglIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKinKDLETKGSLELRQVGQSFNQMTES 237
Cdd:PRK09467 148 HQGDFSPLFRY--TLA--IGLLSVAGGWLFIRIQNRPLVALEHAALQVGKGEIP--PPLREYGASEVRSVTRAFNQMAAG 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 238 LEELLSSQQVLLSSISHELRTPLTRLQLAlallrrrfgednTE-------------IHRIEiearRLDKMINDLLLLSRQ 304
Cdd:PRK09467 222 IKQLEDDRTLLMAGVSHDLRTPLTRIRLA------------TEmmseedgylaesiNKDIE----ECNAIIEQFIDYLRT 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 305 qlHSHVSREIFPINELWEEVLddaifEAEH-RKLNFVVRQNiTQPARyyVNGNKALLVSAIENIVRNALKYTQSEIRVSI 383
Cdd:PRK09467 286 --GQEMPMEMADLNALLGEVI-----AAESgYEREIETALQ-PGPIE--VPMNPIAIKRALANLVVNAARYGNGWIKVSS 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 384 FLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTREtgGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPL 463
Cdd:PRK09467 356 GTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDSARGSS--GTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPL 433
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
171-462 |
7.00e-34 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 132.64 E-value: 7.00e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 171 LLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINkdLETKGSLELRQVGQSFNQMTESLEELLSSQQVLLS 250
Cdd:NF012163 168 LIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTR--VTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 251 SISHELRTPLTRLQLALALLRRRFGEDNTE-IHRIEIEARRLDKMINDLLLLSR---QQLHSHVSreifPINeLWEEVLD 326
Cdd:NF012163 246 DISHELRTPLAVLRAELEAIQDGIRKFTPEsLDSLQAEVGTLTKLVDDLHDLSMsdeGALAYQKA----SVD-LVPLLEV 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 327 daifEAEHRKLNFVVRQ---NITQPARYYVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKR--QELMIVIDDNGHGL 401
Cdd:NF012163 321 ----EGGAFRERFASAGlelEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQrpKEVTLTVADSAPGV 396
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492029959 402 DEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIP 462
Cdd:NF012163 397 SDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVTLP 457
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
171-451 |
1.88e-31 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 125.58 E-value: 1.88e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 171 LLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDlETKGSLELRQVGQSFNQMTESLEELLSSQQVLLS 250
Cdd:TIGR01386 168 LIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLD-PSRAPAELRELAQSFNAMLGRLEDAFQRLSQFSA 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 251 SISHELRTPLTRLQLALALLrrrFGEDNTEIHRIEI------EARRLDKMINDLLLLSR-QQLHSHVSREIFPINELWEE 323
Cdd:TIGR01386 247 DLAHELRTPLTNLLGQTQVA---LSQPRTGEEYREVlesnleELERLSRMVSDMLFLARaDNGQLALERVRLDLAAELAK 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 324 VLDdaIFE--AEHRKLNFVVRQNITqparyyVNGNKALLVSAIENIVRNALKYTQ--SEIRVSIFLKRQELMIVIDDNGH 399
Cdd:TIGR01386 324 VAE--YFEplAEERGVRIRVEGEGL------VRGDPQMFRRAISNLLSNALRHTPdgGTITVRIERRSDEVRVSVSNPGP 395
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 492029959 400 GLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANASQ 451
Cdd:TIGR01386 396 GIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPD 447
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
171-463 |
2.53e-31 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 125.52 E-value: 2.53e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 171 LLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINkdLETKGSLELRQVGQSFNQMTESLEELLSSQQVLLS 250
Cdd:PRK10549 168 LIVALSTLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTR--VTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 251 SISHELRTPLTRLQlalallrrrfGE-----------DNTEIHRIEIEARRLDKMINDLLLLSRQQLHSHVSREIF-PIN 318
Cdd:PRK10549 246 DISHELRTPLAVLR----------GEleaiqdgvrkfTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPvDLV 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 319 ELWEEVLddAIFEAEHRKLNFVVRQNITQPARYYvnGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQE--LMIVIDD 396
Cdd:PRK10549 316 PLLEVAG--GAFRERFASRGLTLQLSLPDSATVF--GDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDktLRLTFAD 391
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492029959 397 NGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPL 463
Cdd:PRK10549 392 SAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 458
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
151-463 |
1.26e-29 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 120.72 E-value: 1.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 151 FIDRvnAQKEIMsfvFANpALLVGLIILVSTPLLWWLARSIGKpirnLQMSAKAVALGDfkiNKDLETKGSLELRQVGQS 230
Cdd:PRK11100 176 FIKR--SERRIL---WAG-ALLLGIALLIGAGVVWWLNRSIRR----LTRYADAVTEGK---PVPLPKLGSSELRELAQA 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 231 FNQMTESLE-----EllssQQVllSSISHELRTPLTRLQLALALLRRRFGEDNTE--IHRIEIEARRLDKMINDLLLLSR 303
Cdd:PRK11100 243 LESMRVKLEgkayvE----QYV--QTLTHELKSPLAAIRGAAELLQEDPPPEDRArfTGNILTQSARLQQLIDRLLELAR 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 304 -QQLHSHVSREIFPINELWEEVLDDAIFEAEHRKLNFVVrqnitQPARYYVNGNKALLVSAIENIVRNALKYT--QSEIR 380
Cdd:PRK11100 317 lEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRL-----RPDDARVLGDPFLLRQALGNLLDNAIDFSpeGGTIT 391
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 381 VSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFY---RVDETRTretgGTGLGLAIVANVVKEHHGAV-WANAsQLGGLC 456
Cdd:PRK11100 392 LSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGRK----STGLGLAFVREVARLHGGEVtLRNR-PEGGVL 466
|
....*..
gi 492029959 457 VTLCIPL 463
Cdd:PRK11100 467 ATLTLPR 473
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
149-463 |
3.01e-29 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 117.59 E-value: 3.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 149 LYFIDRVNAQKEIMSFVFANPALLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLELRQVG 228
Cdd:COG4191 34 ALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 229 QSFNQMTESLEELLSSQQVLL------------SSISHELRTP------LTRLQLALALLRRRFGEDNTEIHRIEIEARR 290
Cdd:COG4191 114 RDITELERAEEELRELQEQLVqseklaalgelaAGIAHEINNPlaailgNAELLRRRLEDEPDPEELREALERILEGAER 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 291 LDKMINDLLLLSRQQlhsHVSREIFPINELWEEVLDdaIFEAEHRKLNFVVRQNItQPARYYVNGNKALLVSAIENIVRN 370
Cdd:COG4191 194 AAEIVRSLRAFSRRD---EEEREPVDLNELIDEALE--LLRPRLKARGIEVELDL-PPDLPPVLGDPGQLEQVLLNLLIN 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 371 AL----KYTQSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYrvdeTrTRETG-GTGLGLAIVANVVKEHHGAV 445
Cdd:COG4191 268 AIdameEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF----T-TKPVGkGTGLGLSISYGIVEKHGGRI 342
|
330
....*....|....*...
gi 492029959 446 WANASQLGGLCVTLCIPL 463
Cdd:COG4191 343 EVESEPGGGTTFTITLPL 360
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
238-443 |
5.80e-29 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 116.15 E-value: 5.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 238 LEELLSSQQVLLSSISHELRTPLTRLQLALALLRRRFGEDNTE----IHRIEIEARRLDKMINDLLLLSRQQLHSH-VSR 312
Cdd:TIGR02966 107 LRRLEQMRRDFVANVSHELRTPLTVLRGYLETLADGPDEDPEEwnraLEIMLEQSQRMQSLVEDLLTLSRLESAASpLED 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 313 EIFPINELWEEVLDDAIFEAEHRKLNFVVrqNITQPAryYVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQELMI 392
Cdd:TIGR02966 187 EPVDMPALLDHLRDEAEALSQGKNHQITF--EIDGGV--DVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRWRRDGGGA 262
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 492029959 393 VID--DNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHG 443
Cdd:TIGR02966 263 EFSvtDTGIGIAPEHLPRLTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHA 315
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
146-462 |
6.04e-29 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 118.97 E-value: 6.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 146 SYTLYFIDRVNAQKEIMSFVfANPALLVGLIILVSTPLL-WWLARSIGKPIRNLQMSAKAVALGDfkINKDLETKGSLEL 224
Cdd:NF040691 167 NYELYLLFPLEDEQSTLALV-RGTLLLGGLALVVLLGLIaWLVTRQVVAPVRSAARTAERFAAGD--LSERMPVKGEDDL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 225 RQVGQSFNQMTES-------LEELLSSQQVLLSSISHELRTPLTRLQLALALLRRRFGE------DNTEIHRIEIEarRL 291
Cdd:NF040691 244 ARLARSFNQMADSlqrqirqLEELSRLQQRFVSDVSHELRTPLTTIRMAADVIHDSRDDfdpataRSAELLHTELD--RF 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 292 DKMINDLLLLSRQQLHSHV-SREIFPINELWEEVLDDAIFEAEHRKLNFVVRQnITQPARYYVNGNKallvsaIENIVR- 369
Cdd:NF040691 322 ESLLSDLLEISRFDAGAAElDVEPVDLRPLVRRVVDALRQLAERAGVELRVDA-PGTPVVAEVDPRR------VERVLRn 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 370 ---NALKYTQSE-IRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHG-- 443
Cdd:NF040691 395 lvvNAIEHGEGKpVVVTVAQDDTAVAVTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGwl 474
|
330 340
....*....|....*....|
gi 492029959 444 AVWanaSQLG-GLCVTLCIP 462
Cdd:NF040691 475 EAW---GRPGqGSQFRLTLP 491
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
170-463 |
6.37e-29 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 117.76 E-value: 6.37e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 170 ALLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFkiNKDLETKGSLELRQVGQSFNQMTESLE---------- 239
Cdd:COG5000 12 LLIALLLLLLALWLALLLARRLTRPLRRLAEATRAVAAGDL--SVRLPVTGDDEIGELARAFNRMTDQLKeqreeleerr 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 --------------------------------------------------------------------------------
Cdd:COG5000 90 ryletilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeieltrdgrrt 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 240 ---------------------ELLSSQQV-----LLSSISHELRTP----LTRLQLALALLRRRFGEDNTEIHR----IE 285
Cdd:COG5000 170 llvrasplrddgyvivfdditELLRAERLaawgeLARRIAHEIKNPltpiQLSAERLRRKLADKLEEDREDLERaldtII 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 286 IEARRLDKMINDLLLLSRQqlhSHVSREIFPINELWEEVLDdaIFEAEHRKLNFVVRQNITQPARYyVNGNKALLVSAIE 365
Cdd:COG5000 250 RQVDRLKRIVDEFLDFARL---PEPQLEPVDLNELLREVLA--LYEPALKEKDIRLELDLDPDLPE-VLADRDQLEQVLI 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 366 NIVRNALKYTQS--EIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYrvdeTrTRETGgTGLGLAIVANVVKEHHG 443
Cdd:COG5000 324 NLLKNAIEAIEEggEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF----T-TKPKG-TGLGLAIVKKIVEEHGG 397
|
410 420
....*....|....*....|
gi 492029959 444 AVWANASQLGGLCVTLCIPL 463
Cdd:COG5000 398 TIELESRPGGGTTFTIRLPL 417
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
8-462 |
2.04e-28 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 117.58 E-value: 2.04e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 8 FFNTISFRIFAFFWLTFSLLSILIFSIPYFDSRIYSELSEKELSAYQQEIITSIRHNQIARILAGVPLSHAERFDGIRPV 87
Cdd:COG4251 42 VLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 88 LVDDVDDSSILGATATEIPLLTQFMFSSSDPTRPLKKVFGDVRIVGPFSIHLGGEANKSYTLYFIDRVNAQKEIMSFVFA 167
Cdd:COG4251 122 LLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 168 NPALLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLELRQVGQSFNQMTESLEELLSSQQV 247
Cdd:COG4251 202 LLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEE 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 248 L---LSSISHELRTPLTRLQLALALLRRRFGEDNTE-----IHRIEIEARRLDKMINDLLLLSRQQlHSHVSREIFPINE 319
Cdd:COG4251 282 LeqfAYVASHDLREPLRKISGFSQLLEEDYGDKLDEegreyLERIRDAAERMQALIDDLLAYSRVG-RQELEFEPVDLNE 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 320 LWEEVLDDAIFEAEHRKLNFVVRQNITqparyyVNGNKALLVSAIENIVRNALKYTQS----EIRVSIFLKRQELMIVID 395
Cdd:COG4251 361 LLEEVLEDLEPRIEERGAEIEVGPLPT------VRGDPTLLRQVFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVR 434
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492029959 396 DNGHGLDEAEYEKIFQPFYRVDetRTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIP 462
Cdd:COG4251 435 DNGIGIDPEYAEKIFEIFQRLH--SRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLP 499
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
355-463 |
9.54e-28 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 106.58 E-value: 9.54e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 355 GNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQE--LMIVIDDNGHGLDEAEYEKIFQPFYRVDEtRTRETGGTGLGLA 432
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGdhVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 492029959 433 IVANVVKEHHGAVWANASQLGGLCVTLCIPL 463
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-463 |
6.92e-26 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 101.35 E-value: 6.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 363 AIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHH 442
Cdd:cd16939 4 ALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVALWHG 83
|
90 100
....*....|....*....|.
gi 492029959 443 GAVWANASQLGGLCVTLCIPL 463
Cdd:cd16939 84 GHVECDDSELGGACFRLTWPR 104
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
170-446 |
1.43e-25 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 109.09 E-value: 1.43e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 170 ALLVGLIILVSTpllwwlaRSIGKPIRNLQMSAKAVALGDFKINKDLETKgSLELRQVGQSFNQMTESLEELLSSQQVLL 249
Cdd:PRK09835 195 SLLIVFIVLLAV-------HKGHAPIRSVSRQIQNITSKDLDVRLDPQTV-PIELEQLVLSFNHMIERIEDVFTRQSNFS 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 250 SSISHELRTPLTRLQLALALLrrrFGEDNTEIHRIEI------EARRLDKMINDLLLLSR---QQLHshVSREIFPINEL 320
Cdd:PRK09835 267 ADIAHEIRTPITNLITQTEIA---LSQSRSQKELEDVlysnleELTRMAKMVSDMLFLAQadnNQLI--PEKKMLDLADE 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 321 WEEVLDdaIFEAEHRKLNFVVRQNITQPAryyVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQE--LMIVIDDNG 398
Cdd:PRK09835 342 VGKVFD--FFEAWAEERGVELRFVGDPCQ---VAGDPLMLRRAISNLLSNALRYTPAGEAITVRCQEVDhqVQLVVENPG 416
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 492029959 399 HGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVW 446
Cdd:PRK09835 417 TPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVA 464
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
360-459 |
3.74e-25 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 99.21 E-value: 3.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 360 LVSAIENIVRNALKYT--QSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRetGGTGLGLAIVANV 437
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|..
gi 492029959 438 VKEHHGAVWANASQLGGLCVTL 459
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTV 100
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
250-463 |
2.98e-24 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 105.60 E-value: 2.98e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 250 SSISHELRTPLtrlqlalallrrrfgednTEIHR----------------------IEIEARRLDKMINDLLLLSR---- 303
Cdd:NF033092 377 ANVSHELRTPL------------------TTMRSylealadgawkdpelaprflgvTQNETERMIRLVNDLLQLSRmdsk 438
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 304 -QQLHshvsREIFPINELWEEVLDDaiFEAEHRKLNFVVRQNITQPARY-YVNGNKALLVsaIENIVRNALKYTQS--EI 379
Cdd:NF033092 439 dYKLN----KEWVNFNEFFNYIIDR--FEMILKNKNITFKREFPKRDLWvEIDTDKITQV--LDNIISNAIKYSPEggTI 510
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 380 RVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANaSQLG-GLCVT 458
Cdd:NF033092 511 TFRLLETHNRIIISISDQGLGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAE-SEEGkGTTIY 589
|
....*
gi 492029959 459 LCIPL 463
Cdd:NF033092 590 FTLPY 594
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
355-463 |
1.42e-23 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 95.13 E-value: 1.42e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 355 GNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQE-LMIVIDDNGHGLDEAEYEKIFQPFYRVDetrTRETGGTGLGLAI 433
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGeLTLTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLSI 77
|
90 100 110
....*....|....*....|....*....|
gi 492029959 434 VANVVKEHHGAVWANASQLGGLCVTLCIPL 463
Cdd:pfam02518 78 VRKLVELLGGTITVESEPGGGTTVTLTLPL 107
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
276-463 |
1.62e-23 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 101.46 E-value: 1.62e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 276 EDNTEIHRIEIEARRLDKMINDLLLLSRQQlhsHVSREIFPINELWEEVLddAIFEAEHRKlNFVVRQNItQPARYYVNG 355
Cdd:COG3852 168 ELREYTQLIIEEADRLNNLVDRLLSFSRPR---PPEREPVNLHEVLERVL--ELLRAEAPK-NIRIVRDY-DPSLPEVLG 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 356 NKALLVSAIENIVRNALKY----------TQSEIRVSIFLKRQELMIVID--DNGHGLDEAEYEKIFQPFYrvdeTrTRE 423
Cdd:COG3852 241 DPDQLIQVLLNLVRNAAEAmpeggtitirTRVERQVTLGGLRPRLYVRIEviDNGPGIPEEILDRIFEPFF----T-TKE 315
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 492029959 424 tGGTGLGLAIVANVVKEHHGAVWANaSQLG-GLCVTLCIPL 463
Cdd:COG3852 316 -KGTGLGLAIVQKIVEQHGGTIEVE-SEPGkGTTFRIYLPL 354
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
364-462 |
2.96e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 94.07 E-value: 2.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 364 IENIVRNALKYTQS--EIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEH 441
Cdd:cd16946 9 FVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAICHNIALAH 88
|
90 100
....*....|....*....|.
gi 492029959 442 HGAVWANASQLGGLCVTLCIP 462
Cdd:cd16946 89 GGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-462 |
5.27e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 90.20 E-value: 5.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 363 AIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTreTGGTGLGLAIVANVVKEHH 442
Cdd:cd16950 4 VLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISDAHG 81
|
90 100
....*....|....*....|
gi 492029959 443 GAVWANASQLGGLCVTLCIP 462
Cdd:cd16950 82 GSLTLANRAGGGLCARIELP 101
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
171-463 |
1.24e-20 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 92.75 E-value: 1.24e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 171 LLVGLIIlvSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSLELRQVGQSFNQMTESLEELLSSQQVLLS 250
Cdd:NF012226 66 ILCGSVI--SLIIGMKLAQRFIVPINFLADAAKKISQGDLSARAEDSQIHSAEISELMHNFNDMAQKLESSVKNAQVWNA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 251 SISHELRTPLTRLQLALALLRRRFGEDNTEIHRIEI-EARRLDKMINDLLLLS---RQQLHSHVsrEIFPINELWEEVLD 326
Cdd:NF012226 144 AIAHELRTPITILQGRLQGILDGVFEPDPALFKSLLnQVEGLSHLVEDLRTLSlveNQQLRLNY--ESVDLKDSIEKVLK 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 327 daIFEAEHRKLNFVVRQNIT-QPARYYVNGNKALLVSAIENIVRNAlkyTQSEIRVSIFLKRQELMIVIDDNGHGLDEAE 405
Cdd:NF012226 222 --MFEDRLEQAQLTIVLNLTaTPVFCDRRRIEQVLIALIDNAIRYA---NAGKLKISSSVIQDDWILQIEDEGPGIAEEY 296
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 492029959 406 YEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWANASQlGGLCVTLCIPL 463
Cdd:NF012226 297 QQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQ-GNSVFTIKLPA 353
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-459 |
9.72e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 84.38 E-value: 9.72e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 352 YVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLK-RQELMIVIDDNGHGLDEAEYEKIFQPFYRVDetrTRETGGTGLG 430
Cdd:cd16940 6 QVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSaDDGAVIRVEDNGPGIDEEELEALFERFYRSD---GQNYGGSGLG 82
|
90 100
....*....|....*....|....*....
gi 492029959 431 LAIVANVVKEHHGAVWANASQLGGLCVTL 459
Cdd:cd16940 83 LSIVKRIVELHGGQIFLGNAQGGGLEAWV 111
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
252-442 |
4.97e-19 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 88.91 E-value: 4.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 252 ISHELRTPLTRLQLALALLrrrfgEDNT--------EIHRIEIEARRLDKMINDLLLLSRQqlhshvsrEIFPINELwEE 323
Cdd:PRK11006 211 VSHELRTPLTVLQGYLEMM-----QDQPlegalrekALHTMREQTQRMEGLVKQLLTLSKI--------EAAPTIDL-NE 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 324 VLD------------DAIFEAEHrKLNFVVRQNITqparyyVNGNKALLVSAIENIVRNALKYTQ--SEIRVSIFLKRQE 389
Cdd:PRK11006 277 KVDvpmmlrvlereaQTLSQGKH-TITFEVDNSLK------VFGNEDQLRSAISNLVYNAVNHTPegTHITVRWQRVPQG 349
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 492029959 390 LMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHH 442
Cdd:PRK11006 350 AEFSVEDNGPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHD 402
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
171-463 |
1.13e-18 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 89.07 E-value: 1.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 171 LLVGLIILVSTPLLWW--LARSIgkpIRNLQMSAKA---VALGDfkINKDLETKGSLEL--------------------- 224
Cdd:TIGR02956 334 LITGMLGLVILVFIMWrvVYRSV---ILRLNQHTQAllrLALGD--LDISLDARGDDELahmgraieafrdtaahnlklq 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 225 ---RQVGQSFNQMTESLEELLSSQ--------------------------------QVLLSSISHELRTPL--TRLQLAL 267
Cdd:TIGR02956 409 adeRQVAQELQEHKESLEQLVAQRtqelaetnerlnaevknhakaraeaeeanrakSAFLATMSHEIRTPLngILGTLEL 488
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 268 ALLRRRFGEDNTEIHRIEIEARRLDKMINDLLLLSR-QQLHSHVSREIFPINELWEEVLddAIFEAEHRKLNFVVRQNIT 346
Cdd:TIGR02956 489 LGDTGLTSQQQQYLQVINRSGESLLDILNDILDYSKiEAGHLSISPRPFDLNALLDDVH--HLMVSRAQLKGIQLRLNIP 566
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 347 QPARYYVNGNKALLVSAIENIVRNALKYT-QSEIRVSIFLKRQ-ELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTreT 424
Cdd:TIGR02956 567 EQLPNWWQGDGPRIRQVLINLVGNAIKFTdRGSVVLRVSLNDDsSLLFEVEDTGCGIAEEEQATLFDAFTQADGRRR--S 644
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 492029959 425 GGTGLGLAIVANVVKEHHGAVWAnASQLG-GLCVTLCIPL 463
Cdd:TIGR02956 645 GGTGLGLAISQRLVEAMDGELGV-ESELGvGSCFWFTLPL 683
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
105-463 |
1.86e-18 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 88.55 E-value: 1.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 105 IPLLTQFMFSSSDPT-----RPLKKVFGDVRIVGPFSI--HLGGEANKSYTLYfiDRVNAQKEIMSFVFAN-PALLVGLI 176
Cdd:PRK15347 230 LPFSTIPLSSNQLQKilnqlENVKLHDGWQQIPDYLVLrtQLKGPGWQQVTLY--PRRNLANEALKPALQQlPFALLILV 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 177 ILVSTpLLWWLARSIGKPIRN-LQMSAKAVALGDfkiNKDLETKGSLELRQVGQSFNQM---------------TESLEE 240
Cdd:PRK15347 308 LLTSV-LFLLLRRYLAKPLWRfVDIINKTGPAAL---EPRLPENRLDELGSIAKAYNQLldtlneqydtlenkvAERTQA 383
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 241 LLSSQQVL----------LSSISHELRTPLTRLQLALALLRRrfGEDNTEIHRIEIEARR----LDKMINDLLLLSR--- 303
Cdd:PRK15347 384 LAEAKQRAeqankrksehLTTISHEIRTPLNGVLGALELLQN--TPLTAEQMDLADTARQctlsLLAIINNLLDFSRies 461
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 304 QQLHSHV-SREIFPInelweevLDDAIF----EAEHRKLNF--VVRQNItqPARYYVNGN--KALLVsaieNIVRNALKY 374
Cdd:PRK15347 462 GQMTLSLeETALLPL-------LDQAMLtiqgPAQSKSLTLrtFVGAHV--PLYLHLDSLrlRQILV----NLLGNAVKF 528
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 375 TQS-EIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETrtreTGGTGLGLAIVANVVKEHHGAVWANaSQLG 453
Cdd:PRK15347 529 TETgGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTH----SQGTGLGLTIASSLAKMMGGELTLF-STPG 603
|
410
....*....|.
gi 492029959 454 -GLCVTLCIPL 463
Cdd:PRK15347 604 vGSCFSLVLPL 614
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
366-463 |
3.68e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 79.84 E-value: 3.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 366 NIVRNALKYT-QSEIRVSIFLKRQE-----LMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVK 439
Cdd:cd16922 7 NLLGNAIKFTeEGEVTLRVSLEEEEedgvqLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKKLVE 86
|
90 100
....*....|....*....|....*
gi 492029959 440 EHHGAVWANaSQLG-GLCVTLCIPL 463
Cdd:cd16922 87 LMGGDISVE-SEPGqGSTFTFTLPL 110
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
356-461 |
9.13e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 78.66 E-value: 9.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 356 NKALLVSAIENIVRNALKYTQSE--IRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRtRETGGTGLGLAI 433
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGgtVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSR-RSGGHYGMGLYI 79
|
90 100
....*....|....*....|....*...
gi 492029959 434 VANVVKEHHGAVWANASQLGGLCVTLCI 461
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVTVKI 107
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
169-462 |
1.02e-17 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 84.25 E-value: 1.02e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 169 PALL-VGLIILVStpllWWLARSIGKPIRNLQMSAK---AVALGDFKINKDletkgSLELRQVGQSFNQMTESLEELLSS 244
Cdd:PRK10755 66 PSLVmVSLTLLIC----FQAVRWITRPLAELQKELEartADNLTPIAIHSS-----TLEIEAVTSALNQLVSRLTSTLDQ 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 245 QQVLLSSISHELRTPLTrlqlalallrrrfG-----EDNTEIHRIEIEA--RRLDKM---INDLLLLSR--QQLHS-H-- 309
Cdd:PRK10755 137 ERLFTADVAHELRTPLA-------------GirlhlELLEKQHHIDVAPliARLDQMmhtVEQLLQLARagQSFSSgHyq 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 310 ----VSREIFPINELWEEVLddaifEAEHRKLNFVvrqniTQPARYYVNGNKALLVSAIENIVRNALKYT--QSEIRVSI 383
Cdd:PRK10755 204 tvklLEDVILPSQDELSEML-----EQRQQTLLLP-----ESAADITVQGDATLLRLLLRNLVENAHRYSpeGSTITIKL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 384 FLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDetrtRETGGTGLGLAIVANVVKEHHGAVW-ANASQLGGLCVTLCIP 462
Cdd:PRK10755 274 SQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMD----SRYGGIGLGLSIVSRITQLHHGQFFlQNRQERSGTRAWVWLP 349
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
235-463 |
1.51e-17 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 85.03 E-value: 1.51e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 235 TE--SLEELLSSQQVL------LSSISHELRTPLTRLQLALALLRRRFGEDN---TEIHRIEIEarRLDKMINDLLLLSR 303
Cdd:COG5809 252 TErkKLEELLRKSEKLsvvgelAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQktyLDIMLSELD--RIESIISEFLVLAK 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 304 QQlhsHVSREIFPINELWEEVLDdaIFEAE----HRKLNFVVRQNItqparYYVNGNKALLVSAIENIVRNALKYTQS-- 377
Cdd:COG5809 330 PQ---AIKYEPKDLNTLIEEVIP--LLQPQallkNVQIELELEDDI-----PDILGDENQLKQVFINLLKNAIEAMPEgg 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 378 EIRVSIFLKRQE-LMIVIDDNGHGLDEAEYEKIFQPFYrvdetrTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLC 456
Cdd:COG5809 400 NITIETKAEDDDkVVISVTDEGCGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTT 473
|
....*..
gi 492029959 457 VTLCIPL 463
Cdd:COG5809 474 FSITLPI 480
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-453 |
3.27e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 74.16 E-value: 3.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 360 LVSAIENIVRNALKYTQSEIRVSIFLKRQE--LMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANV 437
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEEsgARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90
....*....|....*.
gi 492029959 438 VKeHHGAVWANASQLG 453
Cdd:cd16952 81 MS-RHDARLLIASELG 95
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
175-462 |
2.38e-15 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 78.63 E-value: 2.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 175 LIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINKDLETKGSL-ELRQVGQSFNQMTESLEELLSSQQVLLSSIS 253
Cdd:TIGR03785 414 AIMSIGTLALFGFASWISWRIRRLSDDAEAAIDSQGRISGAIPASRSRdEIGDLSRSFAQMVARLRQYTHYLENMSSRLS 493
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 254 HELRTPLTRLQLALALLRRRFGEDNTE--IHRIEIEARRLDKMINDLLLLSR-QQLHSHVSREIFPINELWEEVLDDAIF 330
Cdd:TIGR03785 494 HELRTPVAVVRSSLENLELQALEQEKQkyLERAREGTERLSMILNNMSEATRlEQAIQSAEVEDFDLSEVLSGCMQGYQM 573
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 331 EAEHRKLNFVVRQNiTQPARyyvnGNKALLVSAIENIVRNALKYTQSE--IRVSIFLKRQELMIVIDDNGHGLDEAEYEK 408
Cdd:TIGR03785 574 TYPPQRFELNIPET-PLVMR----GSPELIAQMLDKLVDNAREFSPEDglIEVGLSQNKSHALLTVSNEGPPLPEDMGEQ 648
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 492029959 409 IFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAVWA-NASQLGGLCVTLCIP 462
Cdd:TIGR03785 649 LFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAeNRQQNDGVVFRISLP 703
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
153-460 |
2.63e-15 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 77.77 E-value: 2.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 153 DRVNAQkeIMSFVFANPALLVGLIILVSTPLlwwlarsigKPIRNLqmsAKAVALGDFKINKDLETKG-SLELRQVGQSF 231
Cdd:PRK10337 158 AIVAGQ--LIPWLVALPIMLIILMVLLGREL---------APLKKL---ALALRMRDPDSETPLNATGvPSEVRPLVEAL 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 232 NQMTESLEELLSSQQVLLSSISHELRTPLTRLQLalallrrrfgedNTEIHRI---EIEAR------------RLDKMIN 296
Cdd:PRK10337 224 NQLFARTHAMMVRERRFTSDAAHELRSPLAALKV------------QTEVAQLsddDPQARkkallqlhagidRATRLVD 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 297 DLLLLSRQQLHSHVSrEIFPINelWEEVLDDAIFEAEH--RKLNFVVRQNItqPARYYVNGNKALLVS-AIENIVRNALK 373
Cdd:PRK10337 292 QLLTLSRLDSLDNLQ-DVAEIP--LEDLLQSAVMDIYHtaQQAGIDVRLTL--NAHPVIRTGQPLLLSlLVRNLLDNAIR 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 374 YTQSEIRVSIFLKRQELMIVidDNGHGLDEAEYEKIFQPFYRvdeTRTRETGGTGLGLAIVANVVKEHHGAV-WANASQl 452
Cdd:PRK10337 367 YSPQGSVVDVTLNARNFTVR--DNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVsFGNAPE- 440
|
....*...
gi 492029959 453 GGLCVTLC 460
Cdd:PRK10337 441 GGFEAKVS 448
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
287-463 |
2.98e-15 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 78.09 E-value: 2.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 287 EARRLDKMINDLLLLSRQqlhSHVSREIFPINELWEEVLddaIF--EAEHR-KLNFVVRQNITQPAryyVNGNKALLVSA 363
Cdd:PRK11360 434 EVDRLNKVIDQLLEFSRP---RESQWQPVSLNALVEEVL---QLfqTAGVQaRVDFETELDNELPP---IWADPELLKQV 504
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 364 IENIVRNALKYTQSEIRVSI---FLKRQELMIVIDDNGHGLDEAEYEKIFQPFYrvdetRTRETgGTGLGLAIVANVVKE 440
Cdd:PRK11360 505 LLNILINAVQAISARGKIRIrtwQYSDGQVAVSIEDNGCGIDPELLKKIFDPFF-----TTKAK-GTGLGLALSQRIINA 578
|
170 180
....*....|....*....|....
gi 492029959 441 HHGAVWAnASQLG-GLCVTLCIPL 463
Cdd:PRK11360 579 HGGDIEV-ESEPGvGTTFTLYLPI 601
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-457 |
3.44e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 69.20 E-value: 3.44e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 366 NIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTretgGTGLGLAIVANVVKEHHGAV 445
Cdd:cd16954 44 NLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGGEL 119
|
90
....*....|..
gi 492029959 446 WANASQLGGLCV 457
Cdd:cd16954 120 SLSDSPLGGARF 131
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
360-463 |
1.29e-13 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 72.19 E-value: 1.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 360 LVSAIENIVRNALKYTQS------EIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPfyrvdETRTRETGGTGLGLAI 433
Cdd:COG3290 282 LVTILGNLLDNAIEAVEKlpeeerRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFER-----GFSTKLGEGRGLGLAL 356
|
90 100 110
....*....|....*....|....*....|
gi 492029959 434 VANVVKEHHGAVWANASQLGGLCVTLCIPL 463
Cdd:COG3290 357 VKQIVEKYGGTIEVESEEGEGTVFTVRLPK 386
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-462 |
1.67e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 66.58 E-value: 1.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 360 LVSAIENIVRNALKYTQ----SEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRtrETGGTGLGLAIVA 435
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRprrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSRE--EYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 492029959 436 NVVKEHHGAVWANASQLGGLCVTLCIP 462
Cdd:cd16921 79 KIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
364-462 |
1.69e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 66.75 E-value: 1.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 364 IENIVRNALKYTQSEIRVSIFLKRQEL---MIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKE 440
Cdd:cd16925 9 VLNLLSNAFKFTPDGGRIRCILEKFRLnrfLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLSIVKEFVEL 88
|
90 100
....*....|....*....|..
gi 492029959 441 HHGAVWANASQLGGLCVTLCIP 462
Cdd:cd16925 89 HGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
248-463 |
8.88e-13 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 70.84 E-value: 8.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 248 LLSSISHELRTPLTRLqlalallrrrFGEdnTEI-----------HRIEIEARR-----LDKMINDLLLLSRQQlhshvs 311
Cdd:PRK10490 667 LLAALSHDLRTPLTVL----------FGQ--AEIltldlasegspHARQASEIRqqvlnTTRLVNNLLDMARIQ------ 728
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 312 REIFPINELW---EEVLDDAIFEAEHRKLNFVVRQNITQPARYyVNGNKALLVSAIENIVRNALKYT--QSEIRVSIFLK 386
Cdd:PRK10490 729 SGGFNLRKEWltlEEVVGSALQMLEPGLSGHPINLSLPEPLTL-IHVDGPLFERVLINLLENAVKYAgaQAEIGIDAHVE 807
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492029959 387 RQELMIVIDDNGHGLDEAEYEKIFQPFYRVDetrtRETG--GTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPL 463
Cdd:PRK10490 808 GERLQLDVWDNGPGIPPGQEQLIFDKFARGN----KESAipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPL 882
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
171-463 |
1.35e-12 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 69.93 E-value: 1.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 171 LLVGLIILVSTPLLWW--LARSIGKPIRNLQMSAKAVALGDFKIN-------KDLETKGSL--ELRQVGQSFNQMTESLE 239
Cdd:PRK11466 334 LLLGMVSLCALILILWrvVYRSVTRPLAEQTQALQRLLDGDIDSPfpetagvRELDTIGRLmdAFRSNVHALNRHREQLA 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 240 ELLSSQ-------------------------QVLLSSISHELRTPL--TRLQLALALLRRRFGEDNTEIHRIEIEARRLD 292
Cdd:PRK11466 414 AQVKARtaelqelviehrqaraeaekasqakSAFLAAMSHEIRTPLygILGTAQLLADNPALNAQRDDLRAITDSGESLL 493
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 293 KMINDLLLLSRQQLHSH---VSREIFPINELweevLDDAIFEAEHRKLNFVVR--QNITQPARYYVNGNKALLVSAIENI 367
Cdd:PRK11466 494 TILNDILDYSAIEAGGKnvsVSDEPFEPRPL----LESTLQLMSGRVKGRPIRlaTDIADDLPTALMGDPRRIRQVITNL 569
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 368 VRNALKYT-QSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRtretGGTGLGLAIVANVVKEHHGAVW 446
Cdd:PRK11466 570 LSNALRFTdEGSIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGLTISSRLAQAMGGELS 645
|
330
....*....|....*..
gi 492029959 447 ANASQLGGLCVTLCIPL 463
Cdd:PRK11466 646 ATSTPEVGSCFCLRLPL 662
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
223-464 |
1.45e-12 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 68.82 E-value: 1.45e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 223 ELRQVGQSF--NQMTESLEELLSSQQVLLSSISHELRTPLTRLQLALALLRRRFGEDNTEIHRIEIE-----ARR----L 291
Cdd:PRK09303 127 LLQLSDELFvlRQENETLLEQLKFKDRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIEqlqdqARRqleeI 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 292 DKMINDLLLLSRQqlhshvSREIFPIN-------ELWEEVLDDAIFEAEHRKLNFVvrQNITQ--ParyYVNGNKALLVS 362
Cdd:PRK09303 207 ERLITDLLEVGRT------RWEALRFNpqkldlgSLCQEVILELEKRWLAKSLEIQ--TDIPSdlP---SVYADQERIRQ 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 363 AIENIVRNALKYTQS--EIRVSIfLKR--QELMIVIDDNGHGLDEAEYEKIFQPFYRVDetRTRETGGTGLGLAIVANVV 438
Cdd:PRK09303 276 VLLNLLDNAIKYTPEggTITLSM-LHRttQKVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRRIV 352
|
250 260
....*....|....*....|....*..
gi 492029959 439 KEHHGAVWAnASQLG-GLCVTLCIPLW 464
Cdd:PRK09303 353 RVHYGQIWV-DSEPGqGSCFHFTLPVY 378
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-463 |
3.17e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 62.82 E-value: 3.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 366 NIVRNALKYTQSE--IRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYrvdetRTRETG-GTGLGLAIVANVVKEHH 442
Cdd:cd16943 10 NLLVNAAQAMEGRgrITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFF-----TTKPVGeGTGLGLSLSYRIIQKHG 84
|
90 100
....*....|....*....|..
gi 492029959 443 GAVWAnASQLG-GLCVTLCIPL 463
Cdd:cd16943 85 GTIRV-ASVPGgGTRFTIILPI 105
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
248-466 |
4.06e-12 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 67.89 E-value: 4.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 248 LLSSISHELRTPLTRLQLALALLRRRF---GEDNTEIHRIEIEARRLDKMINDLLLLSRQqlhSHVSREIFPINELWEEV 324
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKGLAKYFAERApagGEAHQLAQVMAKEADRLNRVVSELLELVKP---THLALQAVDLNDLINHS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 325 LDDAIFEAEHRKLNFVVRQNITQPAryyVNGNKALLVSAIENIVRNALKY--TQSEIRVSIFLKRQELMIVIDDNGHGLD 402
Cdd:PRK10364 317 LQLVSQDANSREIQLRFTANDTLPE---IQADPDRLTQVLLNLYLNAIQAigQHGVISVTASESGAGVKISVTDSGKGIA 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492029959 403 EAEYEKIFQPFYrvdetrTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPLWIT 466
Cdd:PRK10364 394 ADQLEAIFTPYF------TTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNIT 451
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
276-443 |
4.51e-12 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 67.83 E-value: 4.51e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 276 EDNTEIHRI---EIEarRLDKMINDLLLLSRQQlhsHVSREIFPINELWEEVLddAIFEAEHRKLNFVVRQNITQPArYY 352
Cdd:COG5805 317 EDKEEYFDImlsELD--RIESIISEFLALAKPQ---AVNKEKENINELIQDVV--TLLETEAILHNIQIRLELLDED-PF 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 353 VNGNKALLVSAIENIVRNALKYTQS--EIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYrvdetrTRETGGTGLG 430
Cdd:COG5805 389 IYCDENQIKQVFINLIKNAIEAMPNggTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFF------TTKEKGTGLG 462
|
170
....*....|...
gi 492029959 431 LAIVANVVKEHHG 443
Cdd:COG5805 463 LMVSYKIIENHNG 475
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
352-449 |
9.09e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 62.15 E-value: 9.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 352 YVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQELMIVID--DNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGL 429
Cdd:cd16947 13 YANANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDiwDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGL 92
|
90 100
....*....|....*....|
gi 492029959 430 GLAIVANVVKEHHGAVWANA 449
Cdd:cd16947 93 GLTITKRLAESMGGSIYVNS 112
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
288-445 |
2.18e-11 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 66.24 E-value: 2.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 288 ARRLdkmINDLLLLSRQQlhsHVSREIFPINELWEEVLddAIFEAEH-RKLNFVVRQnitQPARYYVNGNKALLVSAIEN 366
Cdd:PRK13837 499 ARLI---IDQILAFGRKG---ERNTKPFDLSELVTEIA--PLLRVSLpPGVELDFDQ---DQEPAVVEGNPAELQQVLMN 567
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 367 IVRNALKYTQSEIRVSIFLKRQEL-----------------MIVIDDNGHGLDEAEYEKIFQPFYrvdetrTRETGGTGL 429
Cdd:PRK13837 568 LCSNAAQAMDGAGRVDISLSRAKLrapkvlshgvlppgryvLLRVSDTGAGIDEAVLPHIFEPFF------TTRAGGTGL 641
|
170
....*....|....*.
gi 492029959 430 GLAIVANVVKEHHGAV 445
Cdd:PRK13837 642 GLATVHGIVSAHAGYI 657
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-443 |
6.27e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 58.94 E-value: 6.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 363 AIENIVRNALKYT--QSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDEtrTRETGGTGLGLAIVANVVKE 440
Cdd:cd16923 4 VFSNLLSNAIKYSpeNTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN--SRNTEGAGLGLSIAKAIIEL 81
|
...
gi 492029959 441 HHG 443
Cdd:cd16923 82 HGG 84
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
366-459 |
7.32e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 59.01 E-value: 7.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 366 NIVRNALK--YTQSEIRVSIFLKRQ--ELMIVIDDNGHGLDEAEYEKIFQPFYRvdetrTRETG-GTGLGLAIVANVVKE 440
Cdd:cd16976 7 NLLQNALDamGKVENPRIRIAARRLggRLVLVVRDNGPGIAEEHLSRVFDPFFT-----TKPVGkGTGLGLSISYGIVEE 81
|
90
....*....|....*....
gi 492029959 441 HHGAVWANASQLGGLCVTL 459
Cdd:cd16976 82 HGGRLSVANEEGAGARFTF 100
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-445 |
9.62e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 58.57 E-value: 9.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 360 LVSAIENIVRNA---LKYTQSEIRVSIFLKRQ----------ELMIVIDDNGHGLDEAEYEKIFQPFyrvdeTRTREtGG 426
Cdd:cd16918 1 LIQVFLNLVRNAaqaLAGSGGEIILRTRTQRQvtlghprhrlALRVSVIDNGPGIPPDLQDTIFYPM-----VSGRE-NG 74
|
90
....*....|....*....
gi 492029959 427 TGLGLAIVANVVKEHHGAV 445
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVI 93
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
9-463 |
1.16e-10 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 63.50 E-value: 1.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 9 FNTISFRIFAFFWLTFSLLSILIFSIPYFDSRIYSELSEKELSAYQQEIITSIRHNQIARILAGVPLSHAERFDGIRPVL 88
Cdd:COG2972 1 LSKSLSLLSIVLLLLILLLLVLLILLLSLLLIILLLLLLLILLLLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 89 VDDVDDSSILGATATEIPLLTQFMFSSSDPTRPLkkVFGDVRIVGPFSIHLGGEANKSYTLYFIDRVNAQKEIMSFVFAN 168
Cdd:COG2972 81 LILLLLLLLLLLLILLLSLLLLLALILLLALLLL--LSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 169 PALLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKInkdLETKGSLELRQVGQSFNQMTESLEELLSSQQVL 248
Cdd:COG2972 159 ILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVR---LEVSGNDEIGILARSFNEMVERIKELIEEVYEL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 249 ------------------------LSSISHELRTpltrlqlalallrrrfgEDNTEIHRieiearrldkMINDLLLLSRQ 304
Cdd:COG2972 236 elekkeaelkalqaqinphflfntLNSIRWLAEL-----------------EDPEEAEE----------MLEALSKLLRY 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 305 QLHShvSREIFPINELWEEV----------LDDAI---FEAEHRKLNFVVRQNITQParyyvngnkalLVsaiENIVRNA 371
Cdd:COG2972 289 SLSK--GDELVTLEEELELIksyleiqklrFGDRLeveIEIDEELLDLLIPKLILQP-----------LV---ENAIEHG 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 372 LKYTQS--EIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFyrvdetrTRETGGTGLGLAIVANVVKEHHGA---VW 446
Cdd:COG2972 353 IEPKEGggTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGEeygLE 425
|
490
....*....|....*..
gi 492029959 447 ANASQLGGLCVTLCIPL 463
Cdd:COG2972 426 IESEPGEGTTVTIRIPL 442
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
251-463 |
1.48e-10 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 62.96 E-value: 1.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 251 SISHELRTPLTRLQLALALLRRRFGEDNTEIHRIEI---EARRLDKMINDLLLLSRQQLHSHvsrEIFPINELWEEVLDd 327
Cdd:COG5806 207 SIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIaleELDRAEAIITDYLTFAKPQPEKL---EKIDVSEELEHVID- 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 328 aIFEAEHRKLNFVVRQNITQPAryYVNGNKALLVSAIENIVRNALKYTQS--EIRVSIFLKRQELMIVIDDNGHGLDEAE 405
Cdd:COG5806 283 -VLSPYANMNNVEIQTELEPGL--YIEGDRQKLQQCLINIIKNGIEAMPNggTLTIDVSIDKNKVIISIKDTGVGMTKEQ 359
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 492029959 406 YEKIFQPFYrvdetRTRETgGTGLGLAIVANVVKEHHGAvWANASQLG-GLCVTLCIPL 463
Cdd:COG5806 360 LERLGEPYF-----STKEK-GTGLGTMVSYRIIEAMNGT-IRVESEVGkGTTFTITLPL 411
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
366-457 |
2.07e-10 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 62.73 E-value: 2.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 366 NIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTretgGTGLGLAIVANVVKEHHGAV 445
Cdd:PRK10815 385 NVLDNACKYCLEFVEISARQTDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKI 460
|
90
....*....|..
gi 492029959 446 WANASQLGGLCV 457
Cdd:PRK10815 461 SAGDSPLGGARM 472
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-462 |
2.95e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 57.30 E-value: 2.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 360 LVSAIENIVRNALKYTQS------EIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYrvdetRTRETGGTGLGLAI 433
Cdd:cd16915 1 LITIVGNLIDNALDALAAtgapnkQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGV-----STKGQGERGIGLAL 75
|
90 100
....*....|....*....|....*....
gi 492029959 434 VANVVKEHHGAVWANASQLGGLCVTLCIP 462
Cdd:cd16915 76 VRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-462 |
4.08e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 56.64 E-value: 4.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 359 LLVSAIENIVRNALKYTQSEIRVSIFLKRqELMIVIDDNGHGLDEAEYEKIFQPFYrvdetrTRETGGTGLGLAIVANVV 438
Cdd:cd16920 8 LVRNGIEAMSEGGCERRELTIRTSPADDR-AVTISVKDTGPGIAEEVAGQLFDPFY------TTKSEGLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 492029959 439 KEHHGAVWANASQLGGLCVTLCIP 462
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| HAMP |
pfam00672 |
HAMP domain; |
186-240 |
5.07e-10 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 54.94 E-value: 5.07e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 492029959 186 WLARSIGKPIRNLQMSAKAVALGDFkiNKDLETKGSLELRQVGQSFNQMTESLEE 240
Cdd:pfam00672 1 LLARRILRPLRRLAEAARRIASGDL--DVRLPVSGRDEIGELARAFNQMAERLRE 53
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
363-462 |
1.01e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 55.62 E-value: 1.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 363 AIENIVRNALKYTQS------EIRVSIFLKRQE-LMIVIDDNGHGLDEAEYEKIFQPFYrvdetrTRETGGTGLGLAIVA 435
Cdd:cd16944 8 VLTNILKNAAEAIEGrpsdvgEVRIRVEADQDGrIVLIVCDNGKGFPREMRHRATEPYV------TTRPKGTGLGLAIVK 81
|
90 100
....*....|....*....|....*..
gi 492029959 436 NVVKEHHGAVWANASQLGGLCVTLCIP 462
Cdd:cd16944 82 KIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
249-440 |
1.61e-09 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 60.25 E-value: 1.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 249 LSSISHELRTPLtrlqlalallrrrfgedN-----------TE--------IHRIEIEARRLDKMINDLLLLSRQQLHSH 309
Cdd:PRK11107 297 LANMSHELRTPL-----------------NgvigftrqtlkTPltptqrdyLQTIERSANNLLAIINDILDFSKLEAGKL 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 310 VSREI-FPINELWEEVLDDAIFEAEHRKLNFVVrqNITQPARYYVNGNKALLVSAIENIVRNALKYTQS-EIRVSIFLKR 387
Cdd:PRK11107 360 VLENIpFSLRETLDEVVTLLAHSAHEKGLELTL--NIDPDVPDNVIGDPLRLQQIITNLVGNAIKFTESgNIDILVELRA 437
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 492029959 388 Q-----ELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKE 440
Cdd:PRK11107 438 LsntkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNE 495
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
171-462 |
2.54e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 59.31 E-value: 2.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 171 LLVGLIILVSTPLLWWL--ARSIGKPIRNLQMSAKAVALGDFKInkDLETKGSLE-------LRQVGQSFNQMTESLEE- 240
Cdd:COG4192 329 LAIALLSLLLAVLINYFyvRRRLVKRLNALSDAMAAIAAGDLDV--PIPVDGNDEigriarlLRVFRDQAIEKTQELETe 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 241 ----------LLSSQQVL------------LSSISHELRTPLTRLQLALALLRRRFGEDNTE-----IHRIEIEARRLDK 293
Cdd:COG4192 407 ieerkrieknLRQTQDELiqaakmavvgqtMTSLAHELNQPLNAMSMYLFSAKKALEQENYAqlptsLDKIEGLIERMDK 486
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 294 MINDLLLLSRQQLHSHVSreiFPINELWEEVLDdaIFEAEHRKLNFVvrqnITQPARYYVNGNKALLVSAIENIVRNALK 373
Cdd:COG4192 487 IIKSLRQFSRKSDTPLQP---VDLRQVIEQAWE--LVESRAKPQQIT----LHIPDDLMVQGDQVLLEQVLVNLLVNALD 557
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 374 Y--TQSEIRVSIFLKRQELMIVIDDNGHGLDEAEyeKIFQPFYrvdetrTRETGGTGLGLAIVANVVKEHHGAVWAnASQ 451
Cdd:COG4192 558 AvaTQPQISVDLLSNAENLRVAISDNGNGWPLVD--KLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYL-AST 628
|
330
....*....|..
gi 492029959 452 L-GGLCVTLCIP 462
Cdd:COG4192 629 LeRGAMVILEFN 640
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
189-243 |
7.08e-09 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 51.48 E-value: 7.08e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 492029959 189 RSIGKPIRNLQMSAKAVALGDFkiNKDLETKGSLELRQVGQSFNQMTESLEELLS 243
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDL--TVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
142-258 |
1.62e-08 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 56.95 E-value: 1.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 142 EANKSYTLYFIDRVNAQKEIMSFVFANPALLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFkiNKDLETKGS 221
Cdd:COG0840 157 AAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEGDL--TVRIDVDSK 234
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 492029959 222 LELRQVGQSFNQMTESLEELL-----SSQQVllSSISHELRT 258
Cdd:COG0840 235 DEIGQLADAFNRMIENLRELVgqvreSAEQV--ASASEELAA 274
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
332-463 |
1.75e-08 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 56.87 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 332 AEHRKLNFVVRQNITQPARYYVNGNKalLVSAIENIVRNALKYTQS-EIRVSI-FLKRQELMIVIDDNGHGLDEAEYEKI 409
Cdd:PRK11091 373 AEQKGLRFDLEPLLPLPHKVITDGTR--LRQILWNLISNAVKFTQQgGVTVRVrYEEGDMLTFEVEDSGIGIPEDELDKI 450
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 492029959 410 FQPFYRV-DETRTRETGGTGLGLAIVANVVKEHHGAVWANaSQLG-GLCVTLCIPL 463
Cdd:PRK11091 451 FAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVT-SEEGkGSCFTLTIHA 505
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
7-436 |
2.35e-08 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 56.27 E-value: 2.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 7 SFFNTISFRIFAFFWLTFSLLSILIFSIPYFDSRIYSELSEKELSAYQQEIITSIRHNQIARILAGVPLSHAERFDGIRP 86
Cdd:COG2770 57 LLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLAALALLLLLLLLLAALLALLL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 87 VLVDDVDDSSILGATATEIPLLTQFMFSSSDPTRPLKKVFGDVRIVGPFSIHLGGEANKSYTLYFIDRVNAQKEIMSFVf 166
Cdd:COG2770 137 ALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLGGLLLVVLLEAALAALLLLL- 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 167 anpaLLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFkiNKDLETKGSLELRQVGQSFNQMTESLEELLSSQQ 246
Cdd:COG2770 216 ----LLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDL--DVRIPVSRKDEIGELARAFNRMADSLRESIEEAE 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 247 VLLSSISHELRTPLTRLQLALALLRRRFGEDNTEIHRIEIEARRLDKMINDLLLLSRQQLHSHVSREIFPINELWEEVLD 326
Cdd:COG2770 290 EEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALALAALLLLLALELLL 369
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 327 DAIFEAEHRKLNFVVRQNITQPARYYVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHGLDEAEY 406
Cdd:COG2770 370 EAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLALAAAAAAAEAAAAALELAAAAIAAAA 449
|
410 420 430
....*....|....*....|....*....|
gi 492029959 407 EKIFQPFYRVDETRTRETGGTGLGLAIVAN 436
Cdd:COG2770 450 AAEAEGGLAELEAEELVAAAEALLLLAALL 479
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
193-238 |
3.68e-08 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 49.37 E-value: 3.68e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 492029959 193 KPIRNLQMSAKAVALGDFkiNKDLETKGSLELRQVGQSFNQMTESL 238
Cdd:cd06225 2 RPLRRLTEAARRIAEGDL--DVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
171-445 |
6.36e-08 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 54.89 E-value: 6.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 171 LLVGLIILVSTPLLWWLARSIGKPIRNLQMSAKAVALGDFKINkdLETKGSLELRQVGQSFNQMTESLEELLSSQQVLLS 250
Cdd:COG3850 122 LRLLLALLLALLLAYLLRRRIVRPLRRLTQAAERIARGDFDAR--VPVSGRDELGTLARAFNRMADELQELYAELEEEEE 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 251 SISHELRTPLTRLQLALALLRRRFGEDNTEIHRIEIEARRLDKMINDLLLLSRQQLHSHVSREIFPINELWEEVL----- 325
Cdd:COG3850 200 LEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLLLLQDALAESELLALNILAGLLELLLALLLLLLasall 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 326 -----DDAIFEAEHRKLNFVVRQNITQPARYYVNGNKALLVSAIENIVRNALKYTQSEIRVSIFLKRQELMIVIDDNGHG 400
Cdd:COG3850 280 lleleLLALLLELVELLALAAAEEALLLLVELAALLLLLLLQAIANASLLLIALASVVAALLELASILALQAALEAAAAG 359
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 492029959 401 LDEAEYEKIFQPFYRVDETRTRETGGTGLGLAIVANVVKEHHGAV 445
Cdd:COG3850 360 AALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAGLV 404
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-434 |
1.40e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 49.59 E-value: 1.40e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492029959 360 LVSAIENIVRNALKYTQSEIRVSIFLKRQE--LMIVIDDNGHGLDEAEYEKIFQPFYrVDETRTRETGGTGLGLAIV 434
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEqgVVLSIKDFGIGIPEEDLPRVFDKGF-TGENGRNFQESTGMGLYLV 81
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
358-445 |
5.03e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 47.84 E-value: 5.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 358 ALLVSAIENIVRNALKYTQS--EIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGgTGLGLAIVA 435
Cdd:cd16945 3 FLLRQAINNLLDNAIDFSPEggLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQKS-TGLGLAFVQ 81
|
90
....*....|
gi 492029959 436 NVVKEHHGAV 445
Cdd:cd16945 82 EVAQLHGGRI 91
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
234-433 |
9.29e-07 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 51.51 E-value: 9.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 234 MTESLEELLS-------SQQVLLSSISHELRTPltrlqlalallrrrfgednteihrieiearrLDKMINDLLLLSRQQL 306
Cdd:PRK10841 429 MEESLQEMAQaaeqasqSKSMFLATVSHELRTP-------------------------------LYGIIGNLDLLQTKEL 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 307 HSHVSREIFPIN-------ELWEEVLDDAIFEAEHRKLN---FVVRQNITQ-PARY---------------------YVN 354
Cdd:PRK10841 478 PKGVDRLVTAMNnssslllKIISDILDFSKIESEQLKIEpreFSPREVINHiTANYlplvvkkrlglycfiepdvpvALN 557
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 355 GNKALLVSAIENIVRNALKYTQSE-IRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYRVDETRTRETGGTGLGLAI 433
Cdd:PRK10841 558 GDPMRLQQVISNLLSNAIKFTDTGcIVLHVRVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAI 637
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
390-462 |
4.16e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 45.83 E-value: 4.16e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492029959 390 LMIVIDDNGHGLDEAEYEKIFQPFYrvdetRTRETG-GTGLGLAIVANVVKEHHGAVWANaSQLG-GLCVTLCIP 462
Cdd:cd16919 48 VCLEVSDTGSGMPAEVLRRAFEPFF-----TTKEVGkGTGLGLSMVYGFVKQSGGHLRIY-SEPGvGTTVRIYLP 116
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
360-462 |
1.37e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 44.10 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 360 LVSAIENIVRNALKYTQSE---IRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYrvDETRTRETGGT--GLGLAIV 434
Cdd:cd16953 1 LGQVLRNLIGNAISFSPPDtgrITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFY--TERPANEAFGQhsGLGLSIS 78
|
90 100 110
....*....|....*....|....*....|..
gi 492029959 435 ANVVKEHHGAVWAN----ASQLGGLCVTLCIP 462
Cdd:cd16953 79 RQIIEAHGGISVAEnhnqPGQVIGARFTVQLP 110
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
363-443 |
1.54e-05 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 47.00 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 363 AIENIVRNALKY-----------TQSEIRVSIFLKRQELM--IVIDDNGHGLDEAEYEKIFQPFyrvdeTRTREtGGTGL 429
Cdd:PRK11073 241 VLLNIVRNALQAlgpeggtitlrTRTAFQLTLHGERYRLAarIDIEDNGPGIPPHLQDTLFYPM-----VSGRE-GGTGL 314
|
90
....*....|....
gi 492029959 430 GLAIVANVVKEHHG 443
Cdd:PRK11073 315 GLSIARNLIDQHSG 328
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
282-463 |
2.65e-05 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 45.76 E-value: 2.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 282 HRIEIEARRLDKMINDLLLLSRQQLHShvSREIfpINELWEEVLDDAIFEAEHRKLNFVVRQNITQPARYYVNGNKALLV 361
Cdd:COG4585 81 RLLDADPEAAREELEEIRELAREALAE--LRRL--VRGLRPPALDDLGLAAALEELAERLLRAAGIRVELDVDGDPDRLP 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 362 SAIEN----IVR----NALKYTQ-SEIRVSIFLKRQELMIVIDDNGHGLDEAEyekifqpfyrvdetrtreTGGTGLGLA 432
Cdd:COG4585 157 PEVELalyrIVQealtNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGFDPEA------------------APGGGLGLR 218
|
170 180 190
....*....|....*....|....*....|.
gi 492029959 433 IVANVVKEHHGAVWANASQLGGLCVTLCIPL 463
Cdd:COG4585 219 GMRERAEALGGTLTIGSAPGGGTRVRATLPL 249
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
346-465 |
7.06e-05 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 45.50 E-value: 7.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 346 TQPARYYVNGNKALLVSAIENIVRNALKYT-QSEIRVSIFL-----KRQELMIVIDDNGHGLDEAEYEKIFQPFYRVdeT 419
Cdd:PRK09959 815 TFPDHYLVKIDPQAFKQVLSNLLSNALKFTtEGAVKITTSLghiddNHAVIKMTIMDSGSGLSQEEQQQLFKRYSQT--S 892
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 492029959 420 RTRETGGTGLGLAIVANVVKEHHGAVWANASQLGGLCVTLCIPLWI 465
Cdd:PRK09959 893 AGRQQTGSGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPVEI 938
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
244-303 |
1.09e-04 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 40.27 E-value: 1.09e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492029959 244 SQQVLLSSISHELRTP--LTRLQLALALLRRRFGEDNTEIHRIEIEARRLDKMINDLLLLSR 303
Cdd:pfam00512 1 AKSEFLANLSHELRTPltAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
242-303 |
1.49e-04 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 39.89 E-value: 1.49e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492029959 242 LSSQQVLLSSISHELRTP--LTRLQLALALLRRRFGEDNTE-IHRIEIEARRLDKMINDLLLLSR 303
Cdd:cd00082 1 LQAKGEFLANVSHELRTPltAIRGALELLEEELLDDEEQREyLERIREEAERLLRLINDLLDLSR 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
248-303 |
4.64e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 38.32 E-value: 4.64e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 492029959 248 LLSSISHELRTP--LTRLQLALALLRRRFGEDNTEIHRIEIEARRLDKMINDLLLLSR 303
Cdd:smart00388 5 FLANLSHELRTPltAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
367-463 |
1.22e-03 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 38.74 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 367 IVRNALKYTQS-----EIRVSIFLKRQELMIVIDDNGHGLDEAEYEkifQPFyrvdetrtRETGGTGLGLAIVANVVKEh 441
Cdd:COG2172 42 AVTNAVRHAYGgdpdgPVEVELELDPDGLEIEVRDEGPGFDPEDLP---DPY--------STLAEGGRGLFLIRRLMDE- 109
|
90 100
....*....|....*....|..
gi 492029959 442 hgavWANASQLGGLCVTLCIPL 463
Cdd:COG2172 110 ----VEYESDPGGTTVRLVKRL 127
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
370-463 |
7.07e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 38.73 E-value: 7.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 370 NALKY-----TQSEIRVSIFLKRQELMIVIDDNGHGLDEaeyekifqpfyRVDETRTRetggtGLGLAIVANVVKEHHGA 444
Cdd:COG3920 410 NALKHaflsgEGGRIRVSWRREDGRLRLTVSDNGVGLPE-----------DVDPPARK-----GLGLRLIRALVRQLGGT 473
|
90 100
....*....|....*....|
gi 492029959 445 V-WANASqlgGLCVTLCIPL 463
Cdd:COG3920 474 LeLDRPE---GTRVRITFPL 490
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
360-434 |
9.06e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 38.36 E-value: 9.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 360 LVSAIENIVRNAL----KYTQSEIRVSIFLKRQELMIVIDDNGHGLDEAEYEKIFQPFYrvdetrtrETGGT--GLGLAI 433
Cdd:PRK11086 434 LITILGNLIENALeavgGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGY--------STKGSnrGVGLYL 505
|
.
gi 492029959 434 V 434
Cdd:PRK11086 506 V 506
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
367-462 |
9.45e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 35.22 E-value: 9.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492029959 367 IVR----NALKYTQ-SEIRVSIFLKRQELMIVIDDNGHGLDEAeyekifqpfyrvdetrtRETGGTGLGLAIVANVVKEH 441
Cdd:cd16917 4 IVQealtNALKHAGaSRVRVTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERAELL 66
|
90 100
....*....|....*....|.
gi 492029959 442 HGAVWANASQLGGLCVTLCIP 462
Cdd:cd16917 67 GGTLTIGSRPGGGTRVTARLP 87
|
|
| |
