|
Name |
Accession |
Description |
Interval |
E-value |
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
21-571 |
4.21e-72 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 239.11 E-value: 4.21e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 21 VESRRQKILLKTGALQDAIFNSAYFSSIATDEHGVIQIFNVGAERMLGYhSEDVVDKITPADISDPAEliiraAALSHEL 100
Cdd:COG5809 2 KSSKMELQLRKSEQRFRSLFENAPDAILILDLEGKILKVNPAAERIFGY-TEDELLGTNILDFLHPDD-----EKELREI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 101 NTPITPGfealvfkasrGIEDIYELTYIRKDGSRLSAMVSVTSLRDSAETIIGYLLIGTDNTARKQEEEAqalldqrLRD 180
Cdd:COG5809 76 LKLLKEG----------ESRDELEFELRHKNGKRLEFSSKLSPIFDQNGDIEGMLAISRDITERKRMEEA-------LRE 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 181 QQFYTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFF--TDPASADAAIKRVLSEHKVSDYELTV 258
Cdd:COG5809 139 SEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIhsDDQENVAAFISQLLKDGGIAQGEVRF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 259 RAYDGTETVVSYNAATFHDrDRKLKGVFAAARDVTERKRFERTLEeKNVELehasHMKSEFLATMSHELRTPLNAVIGFS 338
Cdd:COG5809 219 WTKDGRWRLLEASGAPIKK-NGEVDGIVIIFRDITERKKLEELLR-KSEKL----SVVGELAAGIAHEIRNPLTSLKGFI 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 339 EALKDgmvgDMTDAQRRYIGDIFNSGQHLLSLINDILDLSKVEAGMMtlelEPVDLEELLSNSLLIVREQAALQRIQLKL 418
Cdd:COG5809 293 QLLKD----TIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIKY----EPKDLNTLIEEVIPLLQPQALLKNVQIEL 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 419 ETEADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRQvsfaqagviegdwpahtfplpssEYEQFLELSVSDTG 498
Cdd:COG5809 365 ELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKA-----------------------EDDDKVVISVTDEG 421
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492092276 499 IGIAQSDMNKLFKAFSqidsglARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIRPPECEEA 571
Cdd:COG5809 422 CGIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKLSEQVSM 488
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
236-564 |
4.81e-72 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 234.03 E-value: 4.81e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 236 ASADAAIKRVLSEHKVSDYELTVRAYDGTETVVSYNAATFHDRDRKLKGVFAAARDVTERKRFERTLEEKNVELEHASHM 315
Cdd:COG0642 30 LLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANEA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 316 KSEFLATMSHELRTPLNAVIGFSEALKDgmvgDMTDAQRRYIGDIFNSGQHLLSLINDILDLSKVEAGMMTLELEPVDLE 395
Cdd:COG0642 110 KSRFLANVSHELRTPLTAIRGYLELLLE----ELDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLELEPEPVDLA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 396 ELLSNSLLIVREQAALQRIQLKLETEADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRQvsfaqagviEGDWp 475
Cdd:COG0642 186 ELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRR---------EGDR- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 476 ahtfplpsseyeqfLELSVSDTGIGIAQSDMNKLFKAFSQIDSglARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGA 555
Cdd:COG0642 256 --------------VRISVEDTGPGIPPEDLERIFEPFFRTDP--SRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319
|
....*....
gi 492092276 556 RFVVWLPIR 564
Cdd:COG0642 320 TFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
302-566 |
3.61e-70 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 225.94 E-value: 3.61e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 302 LEEKNVELEHASHMKSEFLATMSHELRTPLNAVIGFSEALKDGmVGDMTDAQRRYIGDIFNSGQHLLSLINDILDLSKVE 381
Cdd:COG2205 2 LEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDE-EDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 382 AGMMTLELEPVDLEELLSNSLLIVREQAALQRIQLKLETEADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRQ 461
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 462 VsfaqagviegdwpahtfplpsseyEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSglARKFEGTGLGLAMVKQLTELH 541
Cdd:COG2205 161 E------------------------GDGVRISVSDNGPGIPEEELERIFERFYRGDN--SRGEGGTGLGLAIVKRIVEAH 214
|
250 260
....*....|....*....|....*
gi 492092276 542 GGCVAVASVKDLGARFVVWLPIRPP 566
Cdd:COG2205 215 GGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
275-566 |
7.74e-68 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 224.82 E-value: 7.74e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 275 FHDRDRKLKGVFAAARDVTERKRFERtleeknvelehashMKSEFLATMSHELRTPLNAVIGFSEALKDGMVGDmTDAQR 354
Cdd:COG5002 138 LSALLLGLLLLAAVERDITELERLEQ--------------MRREFVANVSHELRTPLTSIRGYLELLLDGAADD-PEERR 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 355 RYIGDIFNSGQHLLSLINDILDLSKVEAGMMTLELEPVDLEELLSNSLLIVREQAALQRIQLKLETEADFGLLELDRRKT 434
Cdd:COG5002 203 EYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRL 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 435 KQIVYNLLANAVKFSEPGGWVTLAVRQVsfaqagviegdwpahtfplpsseyEQFLELSVSDTGIGIAQSDMNKLFKAFS 514
Cdd:COG5002 283 EQVLTNLLDNAIKYTPEGGTITVSLREE------------------------DDQVRISVRDTGIGIPEEDLPRIFERFY 338
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 492092276 515 QIDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIRPP 566
Cdd:COG5002 339 RVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
177-567 |
5.24e-59 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 200.46 E-value: 5.24e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 177 RLRDQQFYTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFTDPASADAAIKRVLSEHK-VSDYE 255
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRELLERALAEGQpVTERE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 256 LTVRAYDGTETVVSYNAATFHDRDRKlKGVFAAARDVTERKRFERtleeknvELEHASHMKS--EFLATMSHELRTPLNA 333
Cdd:COG3852 81 VTLRRKDGEERPVDVSVSPLRDAEGE-GGVLLVLRDITERKRLER-------ELRRAEKLAAvgELAAGLAHEIRNPLTG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 334 VIGFSEALKDgMVGDmtDAQRRYIGDIFNSGQHLLSLINDILDLSKVEAgmmtLELEPVDLEELLSNSLLIVREQAAlQR 413
Cdd:COG3852 153 IRGAAQLLER-ELPD--DELREYTQLIIEEADRLNNLVDRLLSFSRPRP----PEREPVNLHEVLERVLELLRAEAP-KN 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 414 IQLKLETEADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRQvsfaqagviegdwpAHTFPLPSSEYEQFLELS 493
Cdd:COG3852 225 IRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRV--------------ERQVTLGGLRPRLYVRIE 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492092276 494 VSDTGIGIAQSDMNKLFKAFSqidSGlarKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIRPPE 567
Cdd:COG3852 291 VIDNGPGIPEEILDRIFEPFF---TT---KEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQAE 358
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
165-570 |
7.95e-49 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 181.29 E-value: 7.95e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 165 KQEEEAQalldQRLRDQQFYTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFtdpaSADAAIKR 244
Cdd:PRK11091 141 KEREETQ----IELEQQSSLLRSFLDASPDLVYYRNEDGEFSGCNRAMELLTGKSEKQLIGLTPKDVY----SPEAAEKV 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 245 VLSEHKVSD------YELTVRAYDGTETVVSYNAATFHDRDRKLKGVFAAARDVTERKRFERtleeknvELEHASHMKSE 318
Cdd:PRK11091 213 IETDEKVFRhnvsltYEQWLDYPDGRKACFELRKVPFYDRVGKRHGLMGFGRDITERKRYQD-------ALEKASRDKTT 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 319 FLATMSHELRTPLNAVIGFSEALKDgmvGDMTDAQRRYIGDIFNSGQHLLSLINDILDLSKVEAGMMTLELEPVDLEELL 398
Cdd:PRK11091 286 FISTISHELRTPLNGIVGLSRILLD---TELTAEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKLQLDNQPIDFTDFL 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 399 SNSLLIVREQAALQRIQLKLETEADF-GLLELDRRKTKQIVYNLLANAVKFSEPGGwVTLAVrqvsfaqagviegdwpah 477
Cdd:PRK11091 363 ADLENLSGLQAEQKGLRFDLEPLLPLpHKVITDGTRLRQILWNLISNAVKFTQQGG-VTVRV------------------ 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 478 tfplpSSEYEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFE-GTGLGLAMVKQLTELHGGCVAVASVKDLGAR 556
Cdd:PRK11091 424 -----RYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGGKPAtGTGIGLAVSKRLAQAMGGDITVTSEEGKGSC 498
|
410
....*....|....
gi 492092276 557 FVVWLPIrpPECEE 570
Cdd:PRK11091 499 FTLTIHA--PAVAE 510
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
87-566 |
3.29e-44 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 164.19 E-value: 3.29e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 87 AELIIRAAALSHELNTPITPGFEALVFKASRGIEDIYELTYIRKDGSRLSAMVSVTSLRDSAETIIGYLLIGTDNTARKQ 166
Cdd:COG4251 49 RLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 167 EEEAQALLDQRLRDQQFYTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFTDPASADAAIKRVL 246
Cdd:COG4251 129 LLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 247 SEHKVSDYELTVRAYDGTETVVSYNAATFHDRDRKLKGVFAAARDVT----ERKRFERTLEEKNVELEHASHMKSEFLAT 322
Cdd:COG4251 209 LLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLelrlELEELEEELEERTAELERSNEELEQFAYV 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 323 MSHELRTPLNAVIGFSEALKDGMVGDMTDAQRRYIGDIFNSGQHLLSLINDILDLSKVeaGMMTLELEPVDleellsnSL 402
Cdd:COG4251 289 ASHDLREPLRKISGFSQLLEEDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRV--GRQELEFEPVD-------LN 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 403 LIVREQAALQRIQLKlETEADFGLLEL-----DRRKTKQIVYNLLANAVKFSEPGgwvtlavrqvsfaQAGVIEgdwpah 477
Cdd:COG4251 360 ELLEEVLEDLEPRIE-ERGAEIEVGPLptvrgDPTLLRQVFQNLISNAIKYSRPG-------------EPPRIE------ 419
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 478 tfpLPSSEYEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSglARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARF 557
Cdd:COG4251 420 ---IGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHS--RDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATF 494
|
....*....
gi 492092276 558 VVWLPIRPP 566
Cdd:COG4251 495 YFTLPKAPA 503
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
291-568 |
1.27e-43 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 166.74 E-value: 1.27e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 291 DVTERKRFERT--LEEKNVELEHASHMKSEFLATMSHELRTPLNAVIGFSEALKDGmvgDMTDAQRRYIGDIFNSGQHLL 368
Cdd:PRK15347 371 DTLENKVAERTqaLAEAKQRAEQANKRKSEHLTTISHEIRTPLNGVLGALELLQNT---PLTAEQMDLADTARQCTLSLL 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 369 SLINDILDLSKVEAGMMTLELEPVDLEELLSNSLLIVREQAALQRIQLKLETEADFGL-LELDRRKTKQIVYNLLANAVK 447
Cdd:PRK15347 448 AIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTLRTFVGAHVPLyLHLDSLRLRQILVNLLGNAVK 527
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 448 FSEPGGwVTLAVRQVsfaqagviegdwpahtfplpsseyEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGLArkfeGT 527
Cdd:PRK15347 528 FTETGG-IRLRVKRH------------------------EQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ----GT 578
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 492092276 528 GLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP---IRPPEC 568
Cdd:PRK15347 579 GLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPlneYAPPEP 622
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
170-567 |
1.35e-42 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 157.82 E-value: 1.35e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 170 AQALLDQR--LRDQQFYTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFTDPASADAaIKRVLS 247
Cdd:COG5000 75 TDQLKEQReeLEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAEL-LREALE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 248 EHKVSDYELTVraydGTETVVSYNAATFHDRdrklkGVFAAARDVTErkrfertleeknveLEHASHMKS--EFLATMSH 325
Cdd:COG5000 154 RGWQEEIELTR----DGRRTLLVRASPLRDD-----GYVIVFDDITE--------------LLRAERLAAwgELARRIAH 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 326 ELRTPLNAVIGFSEALKDGMVGDMTDAQ---RRYIGDIFNSGQHLLSLINDILDLSKveagMMTLELEPVDLEELLSNSL 402
Cdd:COG5000 211 EIKNPLTPIQLSAERLRRKLADKLEEDRedlERALDTIIRQVDRLKRIVDEFLDFAR----LPEPQLEPVDLNELLREVL 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 403 LIVREQAALQRIQLKLETEADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRQvsfaqagviEGDWpahtfplp 482
Cdd:COG5000 287 ALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRR---------EDGR-------- 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 483 sseyeqfLELSVSDTGIGIAQSDMNKLFKAFsqidsglarkF----EGTGLGLAMVKQLTELHGGCVAVASVKDLGARFV 558
Cdd:COG5000 350 -------VRIEVSDNGPGIPEEVLERIFEPF----------FttkpKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFT 412
|
....*....
gi 492092276 559 VWLPIRPPE 567
Cdd:COG5000 413 IRLPLAEEA 421
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
307-571 |
1.48e-42 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 163.80 E-value: 1.48e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 307 VELEHASHMKSEFLATMSHELRTPLNAVIGFSEALKDgmvGDMTDAQRRYIGDIFNSGQHLLSLINDILDLSKVEAGMMT 386
Cdd:TIGR02956 455 AEAEEANRAKSAFLATMSHEIRTPLNGILGTLELLGD---TGLTSQQQQYLQVINRSGESLLDILNDILDYSKIEAGHLS 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 387 LELEPVDLEELLSNSLLIVREQAALQRIQLKLETEADF-GLLELDRRKTKQIVYNLLANAVKFSEPGGwVTLAVRQVSfa 465
Cdd:TIGR02956 532 ISPRPFDLNALLDDVHHLMVSRAQLKGIQLRLNIPEQLpNWWQGDGPRIRQVLINLVGNAIKFTDRGS-VVLRVSLND-- 608
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 466 qagviEGDWpahTFplpsseyeqflelSVSDTGIGIAQSDMNKLFKAFSQIDSglARKFEGTGLGLAMVKQLTELHGGCV 545
Cdd:TIGR02956 609 -----DSSL---LF-------------EVEDTGCGIAEEEQATLFDAFTQADG--RRRSGGTGLGLAISQRLVEAMDGEL 665
|
250 260
....*....|....*....|....*.
gi 492092276 546 AVASVKDLGARFvvWLPIRPPECEEA 571
Cdd:TIGR02956 666 GVESELGVGSCF--WFTLPLTRGKPA 689
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
301-543 |
1.21e-40 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 158.09 E-value: 1.21e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 301 TLEE---KNVEL-------EHASHMKSEFLATMSHELRTPLNAVIGFS-EALKDgmvgDMTDAQRRYIGDIFNSGQHLLS 369
Cdd:PRK11107 268 TLEQmeiQNVELdlakkraQEAARIKSEFLANMSHELRTPLNGVIGFTrQTLKT----PLTPTQRDYLQTIERSANNLLA 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 370 LINDILDLSKVEAGMMTLELEPVDLEELLSNSLLIVREQAALQRIQLKLETEAD-----FGllelDRRKTKQIVYNLLAN 444
Cdd:PRK11107 344 IINDILDFSKLEAGKLVLENIPFSLRETLDEVVTLLAHSAHEKGLELTLNIDPDvpdnvIG----DPLRLQQIITNLVGN 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 445 AVKFSEPGgwvTLAVRqvsfaqagvIEgdwpahtfpLPSSEYEQF-LELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARK 523
Cdd:PRK11107 420 AIKFTESG---NIDIL---------VE---------LRALSNTKVqLEVQIRDTGIGISERQQSQLFQAFRQADASISRR 478
|
250 260
....*....|....*....|
gi 492092276 524 FEGTGLGLAMVKQLTELHGG 543
Cdd:PRK11107 479 HGGTGLGLVITQKLVNEMGG 498
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
1-563 |
1.69e-39 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 151.04 E-value: 1.69e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 1 MSTPPADRPLADSQSRAEKIVESRRQKILLKTGALQDAIFNSAYFSSIATDEHGVIQIFNVGAERMLGYHSEDVVDKiTP 80
Cdd:COG5805 1 MSTKLYDFIHEVKKDGTPIWINNEVLRMAIEITEELETILENLPDAIIAVNREGKVIYINPAMEKLLGYTSEEIIGK-TI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 81 ADISDPaeliiraaalshELNTPITPGFEALVF-KASRGIEDIYeltyiRKDGSRLSAMVSVTSLRDSAETIIGYLLIgt 159
Cdd:COG5805 80 FDFLEK------------EYHYRVKTRIERLQKgYDVVMIEQIY-----CKDGELIYVEVKLFPIYNQNGQAAILALR-- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 160 DNTARKQEEEAqalldqrLRDQQFYTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFT--DPAS 237
Cdd:COG5805 141 DITKKKKIEEI-------LQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNLLELLHpcDKEE 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 238 ADAAIKRVLSEHKVSDYELTVRAYDGTETVVSYNAATFHDRDRKLKGVFAAARDVTERKRFERTLeeknvelehashMKS 317
Cdd:COG5805 214 FKERIESITEVWQEFIIEREIITKDGRIRYFEAVIVPLIDTDGSVKGILVILRDITEKKEAEELM------------ARS 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 318 EFL-------ATMSHELRTPLNAVIGFSEALKDGMvgdmtDAQRRYIGDIFNSGQHLLSLINDILDLSKVeagmMTLELE 390
Cdd:COG5805 282 EKLsiagqlaAGIAHEIRNPLTSIKGFLQLLQPGI-----EDKEEYFDIMLSELDRIESIISEFLALAKP----QAVNKE 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 391 PVDLEELLSNSLLIVREQAALQRIQLKLETEADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRqvsfaqagvi 470
Cdd:COG5805 353 KENINELIQDVVTLLETEAILHNIQIRLELLDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTE---------- 422
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 471 egdwpahtfplpssEYEQFLELSVSDTGIGIAQSDMNKLFKAFsqidsgLARKFEGTGLGLAMVKQLTELHGGCVAVASV 550
Cdd:COG5805 423 --------------EEDNSVIIRVIDEGIGIPEERLKKLGEPF------FTTKEKGTGLGLMVSYKIIENHNGTIDIDSK 482
|
570
....*....|...
gi 492092276 551 KDLGARFVVWLPI 563
Cdd:COG5805 483 VGKGTTFTITLPL 495
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
174-567 |
1.39e-36 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 143.96 E-value: 1.39e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 174 LDQRLRDQQFYTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFTDPASADAAIKRVLSEHK-VS 252
Cdd:PRK11360 253 LAQALRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPPNTPFASPLLDTLEHGTeHV 332
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 253 DYELTVRAYDGtETVVSYNAATFHDRDRKLKGVFAAARDVTERKRFERTLeeknvelehashMKSEFLATM-------SH 325
Cdd:PRK11360 333 DLEISFPGRDR-TIELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRV------------ARQERLAALgelvagvAH 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 326 ELRTPLNAVIGFSEALKDGMVGDMTdaqRRYIGDIFNSGQHLLSLINDILDLSKVEAGMMtlelEPVDLEELLSNSLLIV 405
Cdd:PRK11360 400 EIRNPLTAIRGYVQIWRQQTSDPPS---QEYLSVVLREVDRLNKVIDQLLEFSRPRESQW----QPVSLNALVEEVLQLF 472
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 406 REQAALQRIQLKLETEADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRQVSFAQAGViegdwpahtfplpsse 485
Cdd:PRK11360 473 QTAGVQARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAV---------------- 536
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 486 yeqflelSVSDTGIGIAQSDMNKLFKAFsqidsgLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIRP 565
Cdd:PRK11360 537 -------SIEDNGCGIDPELLKKIFDPF------FTTKAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINP 603
|
..
gi 492092276 566 PE 567
Cdd:PRK11360 604 QG 605
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
24-302 |
3.93e-36 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 135.92 E-value: 3.93e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 24 RRQKILLKTGALQDAIFNSAYFSSIATDEHGVIQIFNVGAERMLGYHSEDVVDKiTPADISDPAELIIRaaalshelntp 103
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGK-TLRDLLPPEDDDEF----------- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 104 itpgFEALVFKASRGIEDIYELTYIRKDGSRLSAMVSVTSLRDSAETIIGYLLIGTDNTARKQEEEAqalldqrLRDQQF 183
Cdd:COG2202 69 ----LELLRAALAGGGVWRGELRNRRKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEA-------LRESEE 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 184 YTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFT--DPASADAAIKRVLS-EHKVSDYELTVRA 260
Cdd:COG2202 138 RLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHpeDRERLLELLRRLLEgGRESYELELRLKD 217
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 492092276 261 YDGTETVVSYNAATFHDRDRkLKGVFAAARDVTERKRFERTL 302
Cdd:COG2202 218 GDGRWVWVEASAVPLRDGGE-VIGVLGIVRDITERKRAEEAL 258
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
289-557 |
1.59e-35 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 136.18 E-value: 1.59e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 289 ARDVTERKRFERtleeknvelehashMKSEFLATMSHELRTPLNAVIGFSEALKDGMVGDmTDAQRRYIGDIFNSGQHLL 368
Cdd:TIGR02966 101 ARDVTRLRRLEQ--------------MRRDFVANVSHELRTPLTVLRGYLETLADGPDED-PEEWNRALEIMLEQSQRMQ 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 369 SLINDILDLSKVEAGMMTLELEPVDleeLLSNSLLIVREQAAL-QRIQLKLETEADfGLLEL--DRRKTKQIVYNLLANA 445
Cdd:TIGR02966 166 SLVEDLLTLSRLESAASPLEDEPVD---MPALLDHLRDEAEALsQGKNHQITFEID-GGVDVlgDEDELRSAFSNLVSNA 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 446 VKFSEPGGWVTLavrqvsfaqagviegDWpahtfplpsSEYEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFE 525
Cdd:TIGR02966 242 IKYTPEGGTITV---------------RW---------RRDGGGAEFSVTDTGIGIAPEHLPRLTERFYRVDKSRSRDTG 297
|
250 260 270
....*....|....*....|....*....|..
gi 492092276 526 GTGLGLAMVKQLTELHGGCVAVASVKDLGARF 557
Cdd:TIGR02966 298 GTGLGLAIVKHVLSRHHARLEIESELGKGSTF 329
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
177-563 |
3.50e-35 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 135.70 E-value: 3.50e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 177 RLRDQQFYTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFTDPASADAAIKRVLSEHKVSDYEL 256
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 257 TVRAYDGTETVVSYNAATFHDRDRKLKGVFAAARDVTERKRFERTLEEKNVELEHASHMKS--EFLATMSHELRTPLNAV 334
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAAlgELAAGIAHEINNPLAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 335 IGFSEALKDGMVGDMTDAQ-RRYIGDIFNSGQHLLSLINDILDLSKVEagmmTLELEPVDLEELLSNSLLIVREQAALQR 413
Cdd:COG4191 161 LGNAELLRRRLEDEPDPEElREALERILEGAERAAEIVRSLRAFSRRD----EEEREPVDLNELIDEALELLRPRLKARG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 414 IQLKLETEADFGLLELDRRKTKQIVYNLLANAVK-FSE-PGGWVTLAVRQvsfaqagviEGDWpahtfplpsseyeqfLE 491
Cdd:COG4191 237 IEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDaMEEgEGGRITISTRR---------EGDY---------------VV 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492092276 492 LSVSDTGIGIAQSDMNKLFKAFsqidsglarkF------EGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPI 563
Cdd:COG4191 293 ISVRDNGPGIPPEVLERIFEPF----------FttkpvgKGTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
435-562 |
4.04e-35 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 127.99 E-value: 4.04e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 435 KQIVYNLLANAVKFSEPGGwVTLAVRQVSFAQAGVIegdwpahtfplpsseyeqfLELSVSDTGIGIAQSDMNKLFKAFS 514
Cdd:cd16922 2 RQILLNLLGNAIKFTEEGE-VTLRVSLEEEEEDGVQ-------------------LRFSVEDTGIGIPEEQQARLFEPFS 61
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 492092276 515 QIDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16922 62 QADSSTTRKYGGTGLGLAISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
291-563 |
2.04e-34 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 139.34 E-value: 2.04e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 291 DVTERKRFERTLEEKNVELEHASHMKSEFLATMSHELRTPLNAVIGFSEALKDGMVGDMTDaqrRYIGDIFNSGQHLLSL 370
Cdd:PRK10841 422 DVSARVKMEESLQEMAQAAEQASQSKSMFLATVSHELRTPLYGIIGNLDLLQTKELPKGVD---RLVTAMNNSSSLLLKI 498
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 371 INDILDLSKVEAGMmtLELEPVDLEELLSNSLLIVREQAALQRIQLKLE--TEADF-GLLELDRRKTKQIVYNLLANAVK 447
Cdd:PRK10841 499 ISDILDFSKIESEQ--LKIEPREFSPREVINHITANYLPLVVKKRLGLYcfIEPDVpVALNGDPMRLQQVISNLLSNAIK 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 448 FSEPGGwVTLAVRqvsfaqagvIEGDwpahtfplpsseyeqFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFEGT 527
Cdd:PRK10841 577 FTDTGC-IVLHVR---------VDGD---------------YLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGT 631
|
250 260 270
....*....|....*....|....*....|....*.
gi 492092276 528 GLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPI 563
Cdd:PRK10841 632 GLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
273-562 |
1.57e-30 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 126.02 E-value: 1.57e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 273 ATF---HDRDRKLKGVFAAARDVTERKRFERtlEEKnvelehashmksEFLATMSHELRTPLNAVIGFSEALKDGMVGDM 349
Cdd:NF033092 340 ANFsviQRESGFINGLIAVLHDVTEQEKIEQ--ERR------------EFVANVSHELRTPLTTMRSYLEALADGAWKDP 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 350 TDAQrRYIGDIFNSGQHLLSLINDILDLSKVEAGMMTLELEPVDleellsnslliVRE-----------QAALQRIQLKL 418
Cdd:NF033092 406 ELAP-RFLGVTQNETERMIRLVNDLLQLSRMDSKDYKLNKEWVN-----------FNEffnyiidrfemILKNKNITFKR 473
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 419 ETEADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRqvsfaqagviegdwpahtfplpssEYEQFLELSVSDTG 498
Cdd:NF033092 474 EFPKRDLWVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLL------------------------ETHNRIIISISDQG 529
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492092276 499 IGIAQSDMNKLFKAFSQIDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:NF033092 530 LGIPKKDLDKIFDRFYRVDKARSRKMGGTGLGLAIAKEVVEAHGGRIWAESEEGKGTTIYFTLP 593
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
435-564 |
1.41e-28 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 109.66 E-value: 1.41e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 435 KQIVYNLLANAVKFSEPGGWVTLAVRQvsfaqagviEGDWpahtfplpsseyeqfLELSVSDTGIGIAQSDMNKLFKAFS 514
Cdd:smart00387 7 RQVLSNLLDNAIKYTPEGGRITVTLER---------DGDH---------------VEITVEDNGPGIPPEDLEKIFEPFF 62
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 492092276 515 QIDSGlARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIR 564
Cdd:smart00387 63 RTDKR-SRKIGGTGLGLSIVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
290-563 |
3.06e-28 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 120.61 E-value: 3.06e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 290 RDVTERKRFERTLEEKNVELEHASHMKSEFLATMSHELRTPLNAVIGFSEALKDGmvgDMTDAQR-RYIGDIFNSGQHLL 368
Cdd:PRK09959 686 QDITETRDLIHALEVERNKAINATVAKSQFLATMSHEIRTPISSIMGFLELLSGS---GLSKEQRvEAISLAYATGQSLL 762
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 369 SLINDILDLSKVEAGMMTLELEPVDLEELLSNSLLIVREQAALQRIQLKLE-TEADFGLLELDRRKTKQIVYNLLANAVK 447
Cdd:PRK09959 763 GLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSsTFPDHYLVKIDPQAFKQVLSNLLSNALK 842
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 448 FSEPGGW-VTLAVRQVSFAQAgviegdwpahtfplpsseyeqFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGlaRKFEG 526
Cdd:PRK09959 843 FTTEGAVkITTSLGHIDDNHA---------------------VIKMTIMDSGSGLSQEEQQQLFKRYSQTSAG--RQQTG 899
|
250 260 270
....*....|....*....|....*....|....*..
gi 492092276 527 TGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPI 563
Cdd:PRK09959 900 SGLGLMICKELIKNMQGDLSLESHPGIGTTFTITIPV 936
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
308-566 |
3.66e-28 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 120.01 E-value: 3.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 308 ELEHASHMKSEFLATMSHELRTPLNAVIGFSEALKDgmvGDMTDAQRRYIGDIFNSGQHLLSLINDILDLSKVEAGMMTL 387
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLAD---NPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGGKNV 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 388 EL--EPVDLEELLSNSLLIVreQAALQRIQLKLETEADFGL---LELDRRKTKQIVYNLLANAVKFSEPGgwvtlavrqV 462
Cdd:PRK11466 513 SVsdEPFEPRPLLESTLQLM--SGRVKGRPIRLATDIADDLptaLMGDPRRIRQVITNLLSNALRFTDEG---------S 581
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 463 SFAQAGVIEGDWpahtfplpsseyeqFLElsVSDTGIGIAQSDMNKLFKAFSQidsgLARKFEGTGLGLAMVKQLTELHG 542
Cdd:PRK11466 582 IVLRSRTDGEQW--------------LVE--VEDSGCGIDPAKLAEIFQPFVQ----VSGKRGGTGLGLTISSRLAQAMG 641
|
250 260
....*....|....*....|....
gi 492092276 543 GCVAVASVKDLGARFVVWLPIRPP 566
Cdd:PRK11466 642 GELSATSTPEVGSCFCLRLPLRVA 665
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
289-567 |
4.62e-28 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 119.40 E-value: 4.62e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 289 ARDVTERKRFERtleeknvELEHASHMksEFLATM----SHELRTPLNAVIGFSEalkdgMVGDMTDAQ---RRYIGDIF 361
Cdd:PRK13837 428 RRLETERDALER-------RLEHARRL--EAVGTLasgiAHNFNNILGAILGYAE-----MALNKLARHsraARYIDEII 493
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 362 NSGQHLLSLINDILDLSKVEAGMmtleLEPVDLEEllsnsllIVREQAALQR------IQLKLETEADFGLLELDRRKTK 435
Cdd:PRK13837 494 SAGARARLIIDQILAFGRKGERN----TKPFDLSE-------LVTEIAPLLRvslppgVELDFDQDQEPAVVEGNPAELQ 562
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 436 QIVYNLLANAVKFSEPGGWVTLAVRQVSFAQAGVIegdwpAHTfPLPSSEYEQfleLSVSDTGIGIAQSDMNKLFKAFSQ 515
Cdd:PRK13837 563 QVLMNLCSNAAQAMDGAGRVDISLSRAKLRAPKVL-----SHG-VLPPGRYVL---LRVSDTGAGIDEAVLPHIFEPFFT 633
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 492092276 516 IDSGlarkfeGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIRPPE 567
Cdd:PRK13837 634 TRAG------GTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPPSSKV 679
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
435-561 |
3.67e-25 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 99.60 E-value: 3.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 435 KQIVYNLLANAVKFSEPGGWVTLAVRQVsfaqagviegdwpahtfplpsseyEQFLELSVSDTGIGIAQSDMNKLFKAFS 514
Cdd:cd00075 2 EQVLSNLLDNALKYSPPGGTIEISLRQE------------------------GDGVVLEVEDNGPGIPEEDLERIFERFY 57
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 492092276 515 QIDSglARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWL 561
Cdd:cd00075 58 RGDK--SREGGGTGLGLAIVRRIVEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
430-565 |
9.13e-25 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 98.98 E-value: 9.13e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 430 DRRKTKQIVYNLLANAVKFSEPGGWVTLAVRqvsfaqagviEGDWpahtfplpsseyeqfLELSVSDTGIGIAQSDMNKL 509
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLS----------EGGE---------------LTLTVEDNGIGIPPEDLPRI 56
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 492092276 510 FKAFSQIDSglaRKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIRP 565
Cdd:pfam02518 57 FEPFSTADK---RGGGGTGLGLSIVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
289-565 |
3.11e-24 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 106.08 E-value: 3.11e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 289 ARDVTERKRFE-------------RTLEEKNVELEHASHMKSeFLATMSHELRTPLNAVIGFSEALKDGMVGDmtdAQRR 355
Cdd:PRK11100 217 ADAVTEGKPVPlpklgsselrelaQALESMRVKLEGKAYVEQ-YVQTLTHELKSPLAAIRGAAELLQEDPPPE---DRAR 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 356 YIGDIFNSGQHLLSLINDILDLSKVEAGMMTLELEPVDLEELLSNSLLIVREQAALQRIQLKLETE-----ADFGLLEld 430
Cdd:PRK11100 293 FTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKGITLRLRPDdarvlGDPFLLR-- 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 431 rrktkQIVYNLLANAVKFSEPGGWVTLAVRQVsfaqagviegdwpahtfplpsseyEQFLELSVSDTGIGIAQSDMNKLF 510
Cdd:PRK11100 371 -----QALGNLLDNAIDFSPEGGTITLSAEVD------------------------GEQVALSVEDQGPGIPDYALPRIF 421
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 492092276 511 KAF---SQIDSGlaRKfeGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIRP 565
Cdd:PRK11100 422 ERFyslPRPANG--RK--STGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
302-565 |
7.52e-24 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 105.11 E-value: 7.52e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 302 LEEKNVELEHASHMKSEFLATMSHELRTPLNAVigfsealkdGMVGDMTDAQRryigDIFNSGQ----HLL--------S 369
Cdd:NF040691 257 LQRQIRQLEELSRLQQRFVSDVSHELRTPLTTI---------RMAADVIHDSR----DDFDPATarsaELLhteldrfeS 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 370 LINDILDLSKVEAGMMTLELEPVDLEELLSNSLLIVREQAALQRIQLKLETEADFGLLELDRRKTKQIVYNLLANAVKFS 449
Cdd:NF040691 324 LLSDLLEISRFDAGAAELDVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 450 EpGGWVTLAVRQVSFAQAgviegdwpahtfplpsseyeqfleLSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFEGTGL 529
Cdd:NF040691 404 E-GKPVVVTVAQDDTAVA------------------------VTVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGL 458
|
250 260 270
....*....|....*....|....*....|....*.
gi 492092276 530 GLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIRP 565
Cdd:NF040691 459 GLAIALEDARLHGGWLEAWGRPGQGSQFRLTLPRVA 494
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
309-562 |
4.47e-22 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 99.13 E-value: 4.47e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 309 LEHASHMKSEFLATMSHELRTPLNAVIGFSEALKDGmvgdMTDAQRRYIGDIFNSGQHLLSLINDILDLSKVEAGMMTLE 388
Cdd:NF012163 233 LEKNEQMRRDFMADISHELRTPLAVLRAELEAIQDG----IRKFTPESLDSLQAEVGTLTKLVDDLHDLSMSDEGALAYQ 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 389 LEPVDLEELLSNSLLIVREQAAlQRiQLKLETE-ADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRQVsfaqa 467
Cdd:NF012163 309 KASVDLVPLLEVEGGAFRERFA-SA-GLELEVSlPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISASQR----- 381
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 468 gviegdwpahtfplpsseyEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFEGTGLGLAMVKQLTELHGGCVAV 547
Cdd:NF012163 382 -------------------PKEVTLTVADSAPGVSDEQLARLFERFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHA 442
|
250
....*....|....*
gi 492092276 548 ASVKDLGARFVVWLP 562
Cdd:NF012163 443 AHSPLGGLRIVVTLP 457
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
176-329 |
1.01e-21 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 94.71 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 176 QRLRDQQFYTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFT--DPASADAAIKRVLSEHKVSD 253
Cdd:COG2202 4 EALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPpeDDDEFLELLRAALAGGGVWR 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492092276 254 YELTVRAYDGTETVVSYNAATFHDRDRKLKGVFAAARDVTERKRFERTLEEKNVELEHASHMKSEFLATMSHELRT 329
Cdd:COG2202 84 GELRNRRKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRESEERLRLLVENAPDGIFVLDLDGRI 159
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
151-565 |
1.97e-21 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 96.46 E-value: 1.97e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 151 IIGYLLIGTDNTARKQEEEAQALLDQRlrdqqfytRSLIESNIDALMMTDPQGIISDVNKQMMALTGrtrDELIGAPckn 230
Cdd:COG3290 60 LLLLLLLLLAALLLKLLEEIARLVEER--------EAVLESIREGVIAVDRDGRITLINDAARRLLG---LDAIGRP--- 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 231 fftdpasADAAIKRVLSEHKVsDYELTVRaydgtETVVSYNAATFHDRDRKLkGVFAAARDVTERKRFERtleeknvELE 310
Cdd:COG3290 126 -------IDEVLAEVLETGER-DEEILLN-----GRVLVVNRVPIRDDGRVV-GAVATFRDRTELERLEE-------ELE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 311 HASHMkSEFLATMSHELRTPLNAVIGFSEalkdgmVGDMTDAqRRYIGDIFNSGQHLLSLI-----NDILD---LSKVEa 382
Cdd:COG3290 185 GVKEL-AEALRAQRHDFRNHLHTISGLLQ------LGEYDEA-LEYIDEISEELQELIDSLlsrigNPVLAallLGKAA- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 383 gmmtlelepvdleellsnsllivreQAALQRIQLKLETEADFGLLELDRRKTKQIVYNLLANAV----KFSEPGGWVTLA 458
Cdd:COG3290 256 -------------------------RARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIeaveKLPEEERRVELS 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 459 VRqvsfaqagviegdwpahtfplpssEYEQFLELSVSDTGIGIAQSDMNKLF-KAFSqidsglARKFEGTGLGLAMVKQL 537
Cdd:COG3290 311 IR------------------------DDGDELVIEVEDSGPGIPEELLEKIFeRGFS------TKLGEGRGLGLALVKQI 360
|
410 420
....*....|....*....|....*...
gi 492092276 538 TELHGGCVAVASVKDLGARFVVWLPIRP 565
Cdd:COG3290 361 VEKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
289-564 |
1.26e-19 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 91.61 E-value: 1.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 289 ARDVTERKRFErtleeknvelehasHMKSEFLATMSHELRTPLNAVIGFSE---------ALKDGMVGDMTDAQRRyigd 359
Cdd:PRK11006 191 ARDVTQMHQLE--------------GARRNFFANVSHELRTPLTVLQGYLEmmqdqplegALREKALHTMREQTQR---- 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 360 ifnsgqhLLSLINDILDLSKVEAGMMTLELEPVDLEELLSNsllIVREQAALQRIQLKLETEADFGLLEL-DRRKTKQIV 438
Cdd:PRK11006 253 -------MEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRV---LEREAQTLSQGKHTITFEVDNSLKVFgNEDQLRSAI 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 439 YNLLANAVKFSEPGGWVTLAVRQVSfaqagviegdwpahtfplpsseyeQFLELSVSDTGIGIAQSDMNKLFKAFSQIDS 518
Cdd:PRK11006 323 SNLVYNAVNHTPEGTHITVRWQRVP------------------------QGAEFSVEDNGPGIAPEHIPRLTERFYRVDK 378
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 492092276 519 GLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIR 564
Cdd:PRK11006 379 ARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLPER 424
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
315-383 |
1.39e-19 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 82.61 E-value: 1.39e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492092276 315 MKSEFLATMSHELRTPLNAVIGFSEALKDgmvGDMTDAQRRYIGDIFNSGQHLLSLINDILDLSKVEAG 383
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLD---TELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
315-383 |
2.69e-19 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 81.87 E-value: 2.69e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492092276 315 MKSEFLATMSHELRTPLNAVIGFSEALKDGMVGDMtdaQRRYIGDIFNSGQHLLSLINDILDLSKVEAG 383
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEE---QREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
294-570 |
1.74e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 89.71 E-value: 1.74e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 294 ERKRFERTLEEKNVELEHAShMKSEFLATMSHELRTPLNAVIGFSEALkdgMVgDMTDAQRRYIGDIFNSGQHLLS---L 370
Cdd:PRK10490 643 ERLTLTASEEQARLASEREQ-LRNALLAALSHDLRTPLTVLFGQAEIL---TL-DLASEGSPHARQASEIRQQVLNttrL 717
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 371 INDILDLSKVEAG-------MMTLE---------LEPvdleellsnsllivreqaALQRIQLKLETEADFGLLELDRRKT 434
Cdd:PRK10490 718 VNNLLDMARIQSGgfnlrkeWLTLEevvgsalqmLEP------------------GLSGHPINLSLPEPLTLIHVDGPLF 779
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 435 KQIVYNLLANAVKFSepGGWVTLAVRqvsfaqAGViEGDWpahtfplpsseyeqfLELSVSDTGIGIAQSDMNKLFKAFS 514
Cdd:PRK10490 780 ERVLINLLENAVKYA--GAQAEIGID------AHV-EGER---------------LQLDVWDNGPGIPPGQEQLIFDKFA 835
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 492092276 515 QIDSGLArkFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIR-PPECEE 570
Cdd:PRK10490 836 RGNKESA--IPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLPLEtPPELEE 890
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
430-562 |
2.75e-18 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 80.61 E-value: 2.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 430 DRRKTKQIVYNLLANAVKFSEPGGWVTLAvrqvsfaqagviegdwpahtfpLPSSEYEQFLeLSVSDTGIGIAQSDMNKL 509
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCI----------------------LEKFRLNRFL-LTVSDSGPGIPPNLREEI 57
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 492092276 510 FKAFSQIDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16925 58 FERFRQGDGSSTRAHGGTGLGLSIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
321-563 |
6.03e-18 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 86.76 E-value: 6.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 321 ATMSHELRTPLNAVIG----FSEALKDGmvGDMTDAQRRYIGDIfnsgQHLLSLINDILDLSKVEagmmTLELEPVDLEE 396
Cdd:PRK10364 242 AGVAHEIRNPLSSIKGlakyFAERAPAG--GEAHQLAQVMAKEA----DRLNRVVSELLELVKPT----HLALQAVDLND 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 397 LLSNSLLIVREQAALQRIQLKLETEADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVrqvsfaqagviegdwpa 476
Cdd:PRK10364 312 LINHSLQLVSQDANSREIQLRFTANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTA----------------- 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 477 htfplpsSEYEQFLELSVSDTGIGIAQSDMNKLFKAFsqidsgLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGAR 556
Cdd:PRK10364 375 -------SESGAGVKISVTDSGKGIAADQLEAIFTPY------FTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGAT 441
|
....*..
gi 492092276 557 FVVWLPI 563
Cdd:PRK10364 442 FTLWLPV 448
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
313-379 |
5.86e-17 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 75.33 E-value: 5.86e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492092276 313 SHMKSEFLATMSHELRTPLNAVIGFSEALKDGMVGDmtDAQRRYIGDIFNSGQHLLSLINDILDLSK 379
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDD--EEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
309-562 |
4.38e-16 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 80.89 E-value: 4.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 309 LEHASHMKSEFLATMSHELRTPLNAVIGFSE-ALkdgmvgdmtdAQRR----YIGDIFNSG---QHLLSLINDILDLSKV 380
Cdd:TIGR01386 234 LEDAFQRLSQFSADLAHELRTPLTNLLGQTQvAL----------SQPRtgeeYREVLESNLeelERLSRMVSDMLFLARA 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 381 EAGMMTLELEPVDLEELLSNSLLIVREQAALQRIQLKLETEadfGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVR 460
Cdd:TIGR01386 304 DNGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEGE---GLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIE 380
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 461 QVSfaqagviegdwpahtfplpsseyeQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFEGTGLGLAMVKQLTEL 540
Cdd:TIGR01386 381 RRS------------------------DEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEA 436
|
250 260
....*....|....*....|..
gi 492092276 541 HGGCVAVASvKDLGARFVVWLP 562
Cdd:TIGR01386 437 HGGRASAES-PDGKTRFILRFP 457
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
309-569 |
1.47e-15 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 79.29 E-value: 1.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 309 LEHASHMKSEFLATMSHELRTPLNAVIGFSEALKDGMvgdmtdaqRRYIGDIFNSGQH----LLSLINDILDLSKVEAGM 384
Cdd:PRK10549 233 LEKNEQMRRDFMADISHELRTPLAVLRGELEAIQDGV--------RKFTPESVASLQAevgtLTKLVDDLHQLSLSDEGA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 385 MTLELEPVDLEELLSNSLLIVRE--QAALQRIQLKLETEAD-FGllelDRRKTKQIVYNLLANAVKFSEPGGWVTlavrq 461
Cdd:PRK10549 305 LAYRKTPVDLVPLLEVAGGAFRErfASRGLTLQLSLPDSATvFG----DPDRLMQLFNNLLENSLRYTDSGGSLH----- 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 462 vsfaqagvIEGDWPAHTFplpsseyeqflELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFEGTGLGLAMVKQLTELH 541
Cdd:PRK10549 376 --------ISAEQRDKTL-----------RLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLAICLNIVEAH 436
|
250 260 270
....*....|....*....|....*....|
gi 492092276 542 GGCVaVASVKDLGA-RFVVWLPI-RPPECE 569
Cdd:PRK10549 437 NGRI-IAAHSPFGGvSITVELPLeRDLQRE 465
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
302-563 |
7.03e-15 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 76.53 E-value: 7.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 302 LEEKNVELEHASHMKSEFLATMSHELRTPLNAV-----------IGFSEALKDGMVGDMTDAQRRYIGDIfnsgqhlLSL 370
Cdd:PRK09303 137 LRQENETLLEQLKFKDRVLAMLAHDLRTPLTAAslaletlelgqIDEDTELKPALIEQLQDQARRQLEEI-------ERL 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 371 INDILDLSKVEAGmmTLELEPVDLEELLSNSLLIVREQAALQRIQLKLETE--ADFGLLELDRRKTKQIVYNLLANAVKF 448
Cdd:PRK09303 210 ITDLLEVGRTRWE--ALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQTDipSDLPSVYADQERIRQVLLNLLDNAIKY 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 449 SEPGGWVTLAV--RQvsfaqagviegdwpahtfplpsseyEQFLELSVSDTGIGIAQSDMNKLFK-AFS-QIDSGLarkf 524
Cdd:PRK09303 288 TPEGGTITLSMlhRT-------------------------TQKVQVSICDTGPGIPEEEQERIFEdRVRlPRDEGT---- 338
|
250 260 270
....*....|....*....|....*....|....*....
gi 492092276 525 EGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPI 563
Cdd:PRK09303 339 EGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLPV 377
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
435-561 |
7.05e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 70.90 E-value: 7.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 435 KQIVYNLLANAVKFSEPGGWVTLAVRQVSFAQagviegdwpahtfplpsseyeqfleLSVSDTGIGIAQSDMNKLFKAFS 514
Cdd:cd16940 15 FLLLRNLVDNAVRYSPQGSRVEIKLSADDGAV-------------------------IRVEDNGPGIDEEELEALFERFY 69
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 492092276 515 QIDSglaRKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWL 561
Cdd:cd16940 70 RSDG---QNYGGSGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
321-543 |
3.75e-14 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 73.88 E-value: 3.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 321 ATMSHELRTPLNAVIGFSEALKDGMVgdmtDAQRRYIGDIFNSGQHLLSLINDILDLSKVEAGMMTLELEPVDLEELLSN 400
Cdd:NF012226 143 AAIAHELRTPITILQGRLQGILDGVF----EPDPALFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 401 SLLIVREQaaLQRIQLKLETEADFGLLELDRRKTKQIVYNLLANAVKFSEPGgwvTLAVRQVsfaqagVIEGDWPahtfp 480
Cdd:NF012226 219 VLKMFEDR--LEQAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYANAG---KLKISSS------VIQDDWI----- 282
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492092276 481 lpsseyeqfleLSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFEGTGLGLAMVKQLTELHGG 543
Cdd:NF012226 283 -----------LQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKG 334
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
186-302 |
6.07e-14 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 68.47 E-value: 6.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 186 RSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGapcKNFFT-----DPASADAAIKRVLS-EHKVSDYELTVR 259
Cdd:TIGR00229 6 RAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIG---RNVLElipeeDREEVRERIERRLEgEPEPVSEERRVR 82
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 492092276 260 AYDGTETVVSYNAATfHDRDRKLKGVFAAARDVTERKRFERTL 302
Cdd:TIGR00229 83 RKDGSEIWVEVSVSP-IRTNGGELGVVGIVRDITERKEAEEAL 124
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
436-562 |
1.68e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 66.58 E-value: 1.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 436 QIVYNLLANAVKFSEPG--GWVTLAVRqvsfaqagvIEGDwpAHTFplpsseyeqflelSVSDTGIGIAQSDMNKLFKAF 513
Cdd:cd16921 3 QVLTNLLGNAIKFRRPRrpPRIEVGAE---------DVGE--EWTF-------------YVRDNGIGIDPEYAEKVFGIF 58
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 492092276 514 SQIDSglARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16921 59 QRLHS--REEYEGTGVGLAIVRKIIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
316-562 |
1.89e-13 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 72.88 E-value: 1.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 316 KSEFLATMSHELRTPLNAVIGFSEalkdgMVGDMTDAQRRyIGDIFNSG----QHLLSLINDILDLSKVEAGMMTLELEP 391
Cdd:PRK09835 262 QSNFSADIAHEIRTPITNLITQTE-----IALSQSRSQKE-LEDVLYSNleelTRMAKMVSDMLFLAQADNNQLIPEKKM 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 392 VDLEELLSNSLLIVREQAALQRIQLKLETEAdfGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVrqvsfaqagvie 471
Cdd:PRK09835 336 LDLADEVGKVFDFFEAWAEERGVELRFVGDP--CQVAGDPLMLRRAISNLLSNALRYTPAGEAITVRC------------ 401
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 472 gdwpahtfplpsSEYEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVK 551
Cdd:PRK09835 402 ------------QEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA 469
|
250
....*....|.
gi 492092276 552 DlGARFVVWLP 562
Cdd:PRK09835 470 R-GTRFVISLP 479
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
324-566 |
2.27e-13 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 72.33 E-value: 2.27e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 324 SHELRTPLnAVIGFSEALKDGMVGDMTDAQRRYIGdifnsgqHLLSLINDILDLSKVEAGMMTLELEPVDLEELLSNSLL 403
Cdd:PRK10604 220 AHELRTPL-VRLRYRLEMSDNLSAAESQALNRDIG-------QLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLA 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 404 IVREQAALQRIQLKLETEADFGLleLDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRQvsfaqagviegdwpahtfplps 483
Cdd:PRK10604 292 DIQAVTPEKTVRLDTPHQGDYGA--LDMRLMERVLDNLLNNALRYAHSRVRVSLLLDG---------------------- 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 484 seyeQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPI 563
Cdd:PRK10604 348 ----NQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
...
gi 492092276 564 RPP 566
Cdd:PRK10604 424 WHN 426
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
430-562 |
3.69e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 65.95 E-value: 3.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 430 DRRKTKQIVYNLLANAVKFSEPGGWVTLAVRQVsfaqagviegdwpahtfplpsseyEQFLELSVSDTGIGIAQSDMNKL 509
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQT------------------------PQEVRLDVEDSAPGVSDDQLARL 56
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 492092276 510 FKAFSQIDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16946 57 FERFYRVESSRNRASGGSGLGLAICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
440-564 |
4.45e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 65.69 E-value: 4.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 440 NLLANAVKFSEPGGWVTlaVRqvsfaqagviegdWpahtfplpsSEYEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSG 519
Cdd:cd16952 7 NLVSNAVKYTPPSDTIT--VR-------------W---------SQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIE 62
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 492092276 520 LARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIR 564
Cdd:cd16952 63 RCRNTGGTGLGLAIVKHVMSRHDARLLIASELGKGSRFTCLFPSS 107
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
320-565 |
4.82e-13 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 71.09 E-value: 4.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 320 LATMSHELRTPLNAVIGFSEA-------LKDGMVGDMTDAQrryigdifnsgqhllSLINDILDLSKVEAGMmtlELEPV 392
Cdd:PRK09467 233 MAGVSHDLRTPLTRIRLATEMmseedgyLAESINKDIEECN---------------AIIEQFIDYLRTGQEM---PMEMA 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 393 DLEEllsnsllIVREQAALQ-----RIQLKLETEAdfGLLELDRRKTKQIVYNLLANAVKFSepGGWVtlavrQVSfaqa 467
Cdd:PRK09467 295 DLNA-------LLGEVIAAEsgyerEIETALQPGP--IEVPMNPIAIKRALANLVVNAARYG--NGWI-----KVS---- 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 468 gviegdwpahtfplpSSEYEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSglARKFEGTGLGLAMVKQLTELHGGCVAV 547
Cdd:PRK09467 355 ---------------SGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGDS--ARGSSGTGLGLAIVKRIVDQHNGKVEL 417
|
250
....*....|....*...
gi 492092276 548 ASVKDLGARFVVWLPIRP 565
Cdd:PRK09467 418 GNSEEGGLSARAWLPLTT 435
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
435-562 |
1.16e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 64.39 E-value: 1.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 435 KQIVYNLLANAVKFSepGGWVTLAVrqvsfaqagviEGDWPahtfplpsseyeqFLELSVSDTGIGIAQSDMNKLFKAFS 514
Cdd:cd16950 2 KRVLSNLVDNALRYG--GGWVEVSS-----------DGEGN-------------RTRIQVLDNGPGIAPEEVDELFQPFY 55
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 492092276 515 QIDSglARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16950 56 RGDN--ARGTSGTGLGLAIVQRISDAHGGSLTLANRAGGGLCARIELP 101
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
202-294 |
1.34e-12 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 63.63 E-value: 1.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 202 QGIISDVNKQMMALTGRTRDELIGAPCKNFFTDPaSADAAIKRVLSEHK-VSDYELTVRAYDGTETVVSYNAATFHDRDR 280
Cdd:pfam13426 1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEP-EDSERLREALREGKaVREFEVVLYRKDGEPFPVLVSLAPIRDDGG 79
|
90
....*....|....
gi 492092276 281 KLKGVFAAARDVTE 294
Cdd:pfam13426 80 ELVGIIAILRDITE 93
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
476-562 |
1.03e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 61.57 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 476 AHTFPLPSSEYE-QFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLG 554
Cdd:cd16949 16 SPSKILLDISQDgDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIEQHGGKIKASNRKPGG 95
|
....*...
gi 492092276 555 ARFVVWLP 562
Cdd:cd16949 96 LRVRIWLP 103
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
435-563 |
3.61e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 60.13 E-value: 3.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 435 KQIVYNLLANAVKFSEPGGwvTLAVRqvsfaqagviegdwpahtfplpSSEYEQFLELSVSDTGIGIAQSDMNKLFKAFs 514
Cdd:cd16943 5 NQVLLNLLVNAAQAMEGRG--RITIR----------------------TWAHVDQVLIEVEDTGSGIDPEILGRIFDPF- 59
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 492092276 515 qidsgLARKF--EGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPI 563
Cdd:cd16943 60 -----FTTKPvgEGTGLGLSLSYRIIQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
437-562 |
4.09e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 59.99 E-value: 4.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 437 IVYNLLANAVKFS----EPGGWVTLAVRQvsfaqagviEGDWpahtfplpsseyeqfLELSVSDTGIGIAQSDMNKLF-K 511
Cdd:cd16915 4 IVGNLIDNALDALaatgAPNKQVEVFLRD---------EGDD---------------LVIEVRDTGPGIAPELRDKVFeR 59
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 492092276 512 AFSQIDSGlarkfeGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16915 60 GVSTKGQG------ERGIGLALVRQSVERLGGSITVESEPGGGTTFSIRIP 104
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
186-292 |
1.57e-10 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 58.58 E-value: 1.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 186 RSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGapcKNFF------TDPASADAAIKRVLSEHKVSDYELTVR 259
Cdd:pfam00989 4 RAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIG---KSLLdlipeeDDAEVAELLRQALLQGEESRGFEVSFR 80
|
90 100 110
....*....|....*....|....*....|...
gi 492092276 260 AYDGTETVVSYNAATFHDRDRKLKGVFAAARDV 292
Cdd:pfam00989 81 VPDGRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
194-297 |
1.70e-10 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 58.19 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 194 DALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFTDPASAD--AAIKRVLSEHKVSDyELTVRAYDGTETVVSYN 271
Cdd:pfam08448 6 DALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARleRALRRALEGEEPID-FLEELLLNGEERHYELR 84
|
90 100
....*....|....*....|....*.
gi 492092276 272 AATFHDRDRKLKGVFAAARDVTERKR 297
Cdd:pfam08448 85 LTPLRDPDGEVIGVLVISRDITERRR 110
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
176-343 |
1.85e-10 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 63.25 E-value: 1.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 176 QRLRDQQFYTRSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFtdpasADAAIKRVLSEHKVsdYE 255
Cdd:COG3829 4 LELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELI-----PNSPLLEVLKTGKP--VT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 256 LTVRAYDGTETVVSYNAATFHDrDRKLKGVFAAARDVTERKRFERTLEEKNVELEHAShmkseflatmshelRTPLNAVI 335
Cdd:COG3829 77 GVIQKTGGKGKTVIVTAIPIFE-DGEVIGAVETFRDITELKRLERKLREEELERGLSA--------------KYTFDDII 141
|
....*...
gi 492092276 336 GFSEALKD 343
Cdd:COG3829 142 GKSPAMKE 149
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
193-292 |
2.07e-10 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 58.03 E-value: 2.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 193 IDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFF--TDPASADAAIKRVLSEHKVSDYELTVRAYDGTETVVSY 270
Cdd:cd00130 2 PDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIhpEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVLV 81
|
90 100
....*....|....*....|..
gi 492092276 271 NAATFHDRDRKLKGVFAAARDV 292
Cdd:cd00130 82 SLTPIRDEGGEVIGLLGVVRDI 103
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
435-561 |
6.41e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 56.70 E-value: 6.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 435 KQIVYNLLANAVKFSEPGGWVTLAVRqvsfAQAGVIegdwpahtfplpsseyeqflELSVSDTGIGIAQSDMNKLFKAFS 514
Cdd:cd16945 6 RQAINNLLDNAIDFSPEGGLIALQLE----ADTEGI--------------------ELLVFDEGSGIPDYALNRVFERFY 61
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 492092276 515 QidsgLARKFEG---TGLGLAMVKQLTELHGGCVAVASVKDlGARFVVWL 561
Cdd:cd16945 62 S----LPRPHSGqksTGLGLAFVQEVAQLHGGRITLRNRPD-GVLAFLTL 106
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
38-170 |
1.02e-09 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 56.53 E-value: 1.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 38 AIFNSAYFSSIATDEHGVIQIFNVGAERMLGYHSEDVVDK-----ITPADISDPAELIIRAAALSHELNTpitpgfealv 112
Cdd:TIGR00229 7 AIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRnvlelIPEEDREEVRERIERRLEGEPEPVS---------- 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 492092276 113 fkasrgiediYELTYIRKDGSRLSAMVSVTSLRdSAETIIGYLLIGTDNTARKQEEEA 170
Cdd:TIGR00229 77 ----------EERRVRRKDGSEIWVEVSVSPIR-TNGGELGVVGIVRDITERKEAEEA 123
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
440-562 |
1.36e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 55.51 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 440 NLLANAVKFsepggwvtlAVRQVSFAQagVIEGDWpahtfplpsseyeqfLELSVSDTGIGIAQSDMNKLFKAFSQIDSG 519
Cdd:cd16939 7 NLLRNALRY---------AHRTVRIAL--LVSGGR---------------LTLIVEDDGPGIPAAARERVFEPFVRLDPS 60
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 492092276 520 LARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16939 61 RDRATGGFGLGLAIVHRVALWHGGHVECDDSELGGACFRLTWP 103
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
277-562 |
4.36e-09 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 59.37 E-value: 4.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 277 DRDRKLKGVFAAARDVTERKRFERTLEEKNVELEHASHMKSEFLATMSHELRTPLnAVIgfSEALKDGMVGDMTDAQRRY 356
Cdd:TIGR03785 446 DSQGRISGAIPASRSRDEIGDLSRSFAQMVARLRQYTHYLENMSSRLSHELRTPV-AVV--RSSLENLELQALEQEKQKY 522
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 357 IGDIFNSGQHLLSLINDILDLSKVEAGMMTLELEPVDLEELLSNSLLIVREQAALQRIQLKLETEADF--GLLELdrrkT 434
Cdd:TIGR03785 523 LERAREGTERLSMILNNMSEATRLEQAIQSAEVEDFDLSEVLSGCMQGYQMTYPPQRFELNIPETPLVmrGSPEL----I 598
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 435 KQIVYNLLANAVKFSEPGGWVTLAVrqvsfaqagviegdwpahtfplpsSEYEQFLELSVSDTGIGIAQSDMNKLFKAF- 513
Cdd:TIGR03785 599 AQMLDKLVDNAREFSPEDGLIEVGL------------------------SQNKSHALLTVSNEGPPLPEDMGEQLFDSMv 654
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 492092276 514 SQIDSGLARKFEgTGLGLAMVKQLTELHGGCVAVASV-KDLGARFVVWLP 562
Cdd:TIGR03785 655 SVRDQGAQDQPH-LGLGLYIVRLIADFHQGRIQAENRqQNDGVVFRISLP 703
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
489-562 |
6.04e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 53.55 E-value: 6.04e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492092276 489 FLELSVSDTGIGIAQSDMNKLFKAFsqidsgLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16920 37 AVTISVKDTGPGIAEEVAGQLFDPF------YTTKSEGLGMGLSICRSIIEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
208-563 |
1.12e-08 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 57.76 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 208 VNKQMMALTGRTRDELIGAPCKnFF----TDPASAdAAIKRVLSEHkvSDYELTVRAY--DGTetvvSYNAATF----HD 277
Cdd:PRK13557 58 ANRAFLEMTGYAAEEIIGNNCR-FLqgpeTDRATV-AEVRDAIAER--REIATEILNYrkDGS----SFWNALFvspvYN 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 278 RDRKLKGVFAAARDVTERKRFERTLEEknvelehASHMKS--EFLATMSHELRTPLNAVIGFSEALKDGMVGDMTDAQR- 354
Cdd:PRK13557 130 DAGDLVYFFGSQLDVSRRRDAEDALRQ-------AQKMEAlgQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADRGRm 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 355 -RYIGDIFNSG-------QHLLS------LINDILDLSKVEAGMMTLElepvdleellsnsllivrEQAALQRIQLKLET 420
Cdd:PRK13557 203 aRSVENIRAAAeraatltQQLLAfarkqrLEGRVLNLNGLVSGMGELA------------------ERTLGDAVTIETDL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 421 EADFGLLELDRRKTKQIVYNLLANAVKFSEPGGWVTLAVRQVSFAQAGVIEGDwpahtfPLPSSEYeqfLELSVSDTGIG 500
Cdd:PRK13557 265 APDLWNCRIDPTQAEVALLNVLINARDAMPEGGRVTIRTRNVEIEDEDLAMYH------GLPPGRY---VSIAVTDTGSG 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492092276 501 IAQSDMNKLFKAF-SQIDSGlarkfEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPI 563
Cdd:PRK13557 336 MPPEILARVMDPFfTTKEEG-----KGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFPA 394
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
440-562 |
2.75e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 52.38 E-value: 2.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 440 NLLANAVKFSEPGGWVTLAVRQVsfaqagVIEGDWPAHTFPLPSSEYeqfLELSVSDTGIGIAQSDMNKLFKAFSQIdSG 519
Cdd:cd16919 7 NLAVNARDAMPEGGRLTIETSNQ------RVDADYALNYRDLIPGNY---VCLEVSDTGSGMPAEVLRRAFEPFFTT-KE 76
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 492092276 520 LARkfeGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16919 77 VGK---GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
440-562 |
3.06e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 51.62 E-value: 3.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 440 NLLANAVKFSEPGGWVTLAvrqvsfaqagviegdwpahtfplpSSEYEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSg 519
Cdd:cd16923 7 NLLSNAIKYSPENTRIYIT------------------------SFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDN- 61
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 492092276 520 lARKFEGTGLGLAMVKQLTELHGGcVAVASVKDLGARFVVWLP 562
Cdd:cd16923 62 -SRNTEGAGLGLSIAKAIIELHGG-SASAEYDDNHDLFKVRLP 102
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
319-562 |
6.99e-08 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 54.59 E-value: 6.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 319 FLATMSHELRTPLNAVIGFSEAL-KDGMVGDMTDAQR---------------RyIGDIFNSGQHL-LSLINDILDLSKVE 381
Cdd:PRK10755 140 FTADVAHELRTPLAGIRLHLELLeKQHHIDVAPLIARldqmmhtveqllqlaR-AGQSFSSGHYQtVKLLEDVILPSQDE 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 382 agmmtlelepvdleellsnslliVREQAALQRIQLKL-ETEADFG------LLELdrrktkqIVYNLLANAVKFSEPGGW 454
Cdd:PRK10755 219 -----------------------LSEMLEQRQQTLLLpESAADITvqgdatLLRL-------LLRNLVENAHRYSPEGST 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 455 VTLAVrqvsfaqagviegdwpahtfplpsSEYEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSglarKFEGTGLGLAMV 534
Cdd:PRK10755 269 ITIKL------------------------SQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDS----RYGGIGLGLSIV 320
|
250 260
....*....|....*....|....*....
gi 492092276 535 KQLTELHGGCVAVASVKDL-GARFVVWLP 562
Cdd:PRK10755 321 SRITQLHHGQFFLQNRQERsGTRAWVWLP 349
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
436-561 |
1.80e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 49.38 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 436 QIVYNLLANAV----KFSEPggWVTLAVRqvsfaqagVIEGDWpahtfplpsseyeqflELSVSDTGIGIAQSDMNKLFK 511
Cdd:cd16976 3 QVLMNLLQNALdamgKVENP--RIRIAAR--------RLGGRL----------------VLVVRDNGPGIAEEHLSRVFD 56
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 492092276 512 AF-SQIDSGlarkfEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWL 561
Cdd:cd16976 57 PFfTTKPVG-----KGTGLGLSISYGIVEEHGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
430-562 |
1.86e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 49.59 E-value: 1.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 430 DRRKTKQIVYNLLANAVKFSepggwvtlavrqvsfAQAGVIEgdwpahtfpLPSSEYEQFLELSVSDTGIGIAQSDMNKL 509
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYS---------------KQGGKIE---------IYSETNEQGVVLSIKDFGIGIPEEDLPRV 57
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 492092276 510 FKAFSQIDSGlaRKF-EGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16948 58 FDKGFTGENG--RNFqESTGMGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
440-559 |
3.39e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 49.55 E-value: 3.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 440 NLLANAVKFSEpgGWVTLAVRQVsfaqagviegdwpahtfplpsseyEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSg 519
Cdd:cd16954 44 NLLDNACKWCL--EFVEVTARQT------------------------DGGLHLIVDDDGPGVPESQRSKIFQRGQRLDE- 96
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 492092276 520 larKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVV 559
Cdd:cd16954 97 ---QRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEV 133
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
436-562 |
4.08e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 48.72 E-value: 4.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 436 QIVYNLLANAVKFSEPG-GWVTlavrqVSFAQAGviegdwpahtfplpsseyeQFLELSVSDTGIGIAQSDMNKLFKAFS 514
Cdd:cd16953 3 QVLRNLIGNAISFSPPDtGRIT-----VSAMPTG-------------------KMVTISVEDEGPGIPQEKLESIFDRFY 58
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 492092276 515 QIDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVKD----LGARFVVWLP 562
Cdd:cd16953 59 TERPANEAFGQHSGLGLSISRQIIEAHGGISVAENHNQpgqvIGARFTVQLP 110
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
320-563 |
5.07e-07 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 52.24 E-value: 5.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 320 LATMSHELRTPLnAVIGFSEALKDGMVGDMTDAQRryigdIFNSGQHLLSLINDILDLSkveagmmtlelepvdleells 399
Cdd:PRK09470 247 LSDISHELRTPL-TRLQLATALLRRRQGESKELER-----IETEAQRLDSMINDLLVLS--------------------- 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 400 nsllivreqaalqRIQLKLEteadfglLELDRRKTKQIVYNLLANAvKF------------SEPGGW------VTLA--- 458
Cdd:PRK09470 300 -------------RNQQKNH-------LERETFKANSLWSEVLEDA-KFeaeqmgksltvsAPPGPWpingnpNALAsal 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 459 ---VR----------QVSFaqagviegdwpahtfplpsSEYEQFLELSVSDTGIGIAQSDMNKLFKAFSQIDSGLARKFE 525
Cdd:PRK09470 359 eniVRnalryshtkiEVAF-------------------SVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESG 419
|
250 260 270
....*....|....*....|....*....|....*....
gi 492092276 526 GTGLGLAMVKQLTELHGGCVaVASVKDLGA-RFVVWLPI 563
Cdd:PRK09470 420 GTGLGLAIVENAIQQHRGWV-KAEDSPLGGlRLTIWLPL 457
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
292-555 |
5.18e-07 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 52.77 E-value: 5.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 292 VTERKRFERTLEEKNVELEHASHMKS--EFLATMSHELRTPLNAVIGFSEALKDGMVGDMTDAQRRYIGDIFNSGQHLLS 369
Cdd:COG4192 407 IEERKRIEKNLRQTQDELIQAAKMAVvgQTMTSLAHELNQPLNAMSMYLFSAKKALEQENYAQLPTSLDKIEGLIERMDK 486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 370 LINDILDLSKVEAGmmtlELEPVDLEELLSNSLLIVREQAALQRIQLKLETE----ADFGLLEldrrktkQIVYNLLANA 445
Cdd:COG4192 487 IIKSLRQFSRKSDT----PLQPVDLRQVIEQAWELVESRAKPQQITLHIPDDlmvqGDQVLLE-------QVLVNLLVNA 555
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 446 VKFSEPGGWVTLAVrqvsfaqagviegdwpahtfpLPSSEYeqfLELSVSDTGIGIAQSDmnKLFKAFSqidsglARKFE 525
Cdd:COG4192 556 LDAVATQPQISVDL---------------------LSNAEN---LRVAISDNGNGWPLVD--KLFTPFT------TTKEV 603
|
250 260 270
....*....|....*....|....*....|
gi 492092276 526 GTGLGLAMVKQLTELHGGCVAVASVKDLGA 555
Cdd:COG4192 604 GLGLGLSICRSIMQQFGGDLYLASTLERGA 633
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
430-562 |
5.55e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 48.30 E-value: 5.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 430 DRRKTKQIVYNLLANAvkfsepggwvtlavrqvsfaqAGVIEG--DWPAHTFPLPSSEYEQFLELSVSDTGIGIAQSDMN 507
Cdd:cd16944 1 DTTQISQVLTNILKNA---------------------AEAIEGrpSDVGEVRIRVEADQDGRIVLIVCDNGKGFPREMRH 59
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 492092276 508 KLFKAFsqidsgLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLP 562
Cdd:cd16944 60 RATEPY------VTTRPKGTGLGLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
436-549 |
6.25e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 48.17 E-value: 6.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 436 QIVYNLLANAVKFSEP-GGWVTLAVRQvsfaqagviegdwpAHTFPLPSSEYEQFLELSVSDTGIGIAQSDMNKLFKAFs 514
Cdd:cd16918 3 QVFLNLVRNAAQALAGsGGEIILRTRT--------------QRQVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPM- 67
|
90 100 110
....*....|....*....|....*....|....*
gi 492092276 515 qidsgLARKFEGTGLGLAMVKQLTELHGGCVAVAS 549
Cdd:cd16918 68 -----VSGRENGTGLGLAIAQNIVSQHGGVIECDS 97
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
186-247 |
1.04e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 46.24 E-value: 1.04e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492092276 186 RSLIESNIDALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFF--TDPASADAAIKRVLS 247
Cdd:smart00091 4 RAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIhpEDRERVQEALQRLLS 67
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
436-549 |
1.19e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 47.89 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 436 QIVYNLLANAVKFSEPGGWVTLAVRqvsfaqagviegdwpahtfplpssEYEQFLELSVSDTGIGIAQSDMNKLFKAFSQ 515
Cdd:cd16947 23 RILKNLISNAIKYGSDGKFLGMTLR------------------------EDEKHVYIDIWDKGKGISETEKDHVFERLYT 78
|
90 100 110
....*....|....*....|....*....|....
gi 492092276 516 IDSGLARKFEGTGLGLAMVKQLTELHGGCVAVAS 549
Cdd:cd16947 79 LEDSRNSAKQGNGLGLTITKRLAESMGGSIYVNS 112
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
53-163 |
1.31e-06 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 46.69 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 53 HGVIQIFNVGAERMLGYHSEDVVDKitpadisDPAELIIRaaalshelntPITPGFEALVFKASRGIEDiYELTYIRKDG 132
Cdd:pfam13426 1 DGRIIYVNDAALRLLGYTREELLGK-------SITDLFAE----------PEDSERLREALREGKAVRE-FEVVLYRKDG 62
|
90 100 110
....*....|....*....|....*....|.
gi 492092276 133 SRLSAMVSVTSLRDSAETIIGYLLIGTDNTA 163
Cdd:pfam13426 63 EPFPVLVSLAPIRDDGGELVGIIAILRDITE 93
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
37-160 |
5.45e-06 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 45.49 E-value: 5.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 37 DAIFNSAYFSSIATDEHGVIQIFNVGAERMLGYHSEDVVDKItpadisdpaeliiraaaLSHELNTPITPGFEALVFKAS 116
Cdd:pfam00989 4 RAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKS-----------------LLDLIPEEDDAEVAELLRQAL 66
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 492092276 117 RGIED--IYELTYIRKDGSRLSAMVSVTSLRDSAETIIGYLLIGTD 160
Cdd:pfam00989 67 LQGEEsrGFEVSFRVPDGRPRHVEVRASPVRDAGGEILGFLGVLRD 112
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
48-160 |
5.86e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 45.32 E-value: 5.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 48 IATDEHGVIQIFNVGAERMLGYHSEDVVDKiTPADISDPAELIIRAAALSHELNtpitpgfealvfkasRGIEDIYELTY 127
Cdd:cd00130 6 IVLDLDGRILYANPAAEQLLGYSPEELIGK-SLLDLIHPEDREELRERLENLLS---------------GGEPVTLEVRL 69
|
90 100 110
....*....|....*....|....*....|...
gi 492092276 128 IRKDGSRLSAMVSVTSLRDSAETIIGYLLIGTD 160
Cdd:cd00130 70 RRKDGSVIWVLVSLTPIRDEGGEVIGLLGVVRD 102
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
490-567 |
6.15e-06 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 49.14 E-value: 6.15e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492092276 490 LELSVSDTGIGIAQSDMNKLFkafsqiDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIRPPE 567
Cdd:PRK11086 468 LHCEVSDDGPGIAPDEIDAIF------DKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGER 539
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
430-560 |
2.11e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 43.60 E-value: 2.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 430 DRRKTKQIVYNLLANAVKFSEPGGWVTLAVRqvsfaqagviegdwpahtfplpssEYEQFLELSVSDTGIGIAQSDMNKL 509
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIY------------------------DEEEYLYFEIWDNGHGFSEQDLKKA 56
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 492092276 510 FKAFSQIDSGlARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVW 560
Cdd:cd16975 57 LELFYRDDTS-RRSGGHYGMGLYIAKNLVEKHGGSLIIENSQKGGAEVTVK 106
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
19-312 |
4.23e-05 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 46.59 E-value: 4.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 19 KIVESRRQKILLKTGALQDAIFNSAYFssiaTDEHGVIQIFNVGAERMLGYHSEDVVDKiTPADIsDPAELIIRAAALSH 98
Cdd:PRK13560 193 KRAEERIDEALHFLQQLLDNIADPAFW----KDEDAKVFGCNDAACLACGFRREEIIGM-SIHDF-APAQPADDYQEADA 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 99 ELNTPitPGFEalvfkasrgiedIYELTYIRKDGSRLSAMVSVT--SLRDSAETIIGYLLIGTDNTARKQEEEAQALLDQ 176
Cdd:PRK13560 267 AKFDA--DGSQ------------IIEAEFQNKDGRTRPVDVIFNhaEFDDKENHCAGLVGAITDISGRRAAERELLEKED 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 177 RLRdqqfytrSLIESNIDALMMTDPQGIISDVNKQMM-ALTGRTRDELIGAP-------------CKNF-----FTDPAS 237
Cdd:PRK13560 333 MLR-------AIIEAAPIAAIGLDADGNICFVNNNAAeRMLGWSAAEVMGKPlpgmdpelneefwCGDFqewypDGRPMA 405
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492092276 238 ADAA-IKRVLSEHKVSD-YELTVRAYDGTETVVSYNAATFHDRDRKLKGVFAAARDVTERKRFERTLEEKNVELEHA 312
Cdd:PRK13560 406 FDACpMAKTIKGGKIFDgQEVLIEREDDGPADCSAYAEPLHDADGNIIGAIALLVDITERKQVEEQLLLANLIVENS 482
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
17-182 |
8.57e-05 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 45.15 E-value: 8.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 17 AEKIVESRRQKILlktgalqDAIFNSAYFSSIATDEHGVIQIFNVGAERMLGYHSEDVVDKitpaDISDpaeliiraaaL 96
Cdd:COG3829 1 AEELELKELEEEL-------EAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGK----NVTE----------L 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 97 SHELNTPItpgfealVFKASRGIEDIyeltYIRKDGSRLSAMVSVTSLRDSAEtIIGYLLIGTDNTARKQeeeaqalLDQ 176
Cdd:COG3829 60 IPNSPLLE-------VLKTGKPVTGV----IQKTGGKGKTVIVTAIPIFEDGE-VIGAVETFRDITELKR-------LER 120
|
....*.
gi 492092276 177 RLRDQQ 182
Cdd:COG3829 121 KLREEE 126
|
|
| PRK13559 |
PRK13559 |
hypothetical protein; Provisional |
195-343 |
1.09e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 237427 [Multi-domain] Cd Length: 361 Bit Score: 44.81 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 195 ALMMTDPQG---IISDVNKQMMALTGRTRDELIGAPCKnFFTDPASADAAIKRV---LSEHKVSDYELTVRAYDGTETVV 268
Cdd:PRK13559 55 AMCITDPHQpdlPIVLANQAFLDLTGYAAEEVVGRNCR-FLQGAATDPIAVAKIraaIAAEREIVVELLNYRKDGEPFWN 133
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492092276 269 SYNAATFHDRDRKLKGVFAAARDVTERKRfERTLEeknvelEHASHMksefLATMSHELRTPL---NAVIGFSEALKD 343
Cdd:PRK13559 134 ALHLGPVYGEDGRLLYFFGSQWDVTDIRA-VRALE------AHERRL----AREVDHRSKNVFavvDSIVRLTGRADD 200
|
|
| HATPase_ETR2_ERS2-EIN4-like |
cd16938 |
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related ... |
430-561 |
1.21e-04 |
|
Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains; This family includes the histidine kinase-like ATPase domains (HATPase) of three out of the five receptors that recognize the plant hormone ethylene in Arabidopsis thaliana. These three proteins have been classified as belonging to subfamily 2: ETR2, ERS2, and EIN4. They lack most of the motifs characteristic of histidine kinases, and EIN4 is the only one in this group containing the conserved histidine that is phosphorylated in two-component and phosphorelay systems. This family also includes the HATPase domains of Escherichia coli RcsD phosphotransferase which is a component of the Rcs-signaling system, a complex multistep phosphorelay involving five proteins, and is involved in many transcriptional networks such as cell division, biofilm formation, and virulence, among others. Also included is Schizosaccharomyces pombe Mak3 (Phk1) which participates in a multi-step two-component related system which regulates H2O2-induced activation of the Sty1 stress-activated protein kinase pathway. Most proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a GAF sensor domain; most are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340415 [Multi-domain] Cd Length: 133 Bit Score: 42.06 E-value: 1.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 430 DRRKTKQIVYNLLANAVKFSEPGGWVTLAVR--QVSFAQAGVIEGDWPAHTfplpSSEYEQfLELSVSDTGIGiaqSDMN 507
Cdd:cd16938 8 DERRVFQVLLHMLGNLLKMRNGGGNITFRVFleGGSEDRSDRDWGPWRPSM----SDESVE-IRFEVEINDSG---SPSI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 492092276 508 KLFKAFSQIDSGLARKFEGTGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWL 561
Cdd:cd16938 80 ESASMRNSLNRRYNLSELGEHLSFSICKQLVQLMGGNIWIVPGSGLGTTMSLLL 133
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
484-564 |
6.21e-04 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 42.31 E-value: 6.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 484 SEYEQFLELSVSDTGIGIAQSDMNKLFkafsqidSGLARKFEGTGLGLAMVKQLTELH---GGCVAVASVKDLGARFVVW 560
Cdd:COG2972 367 RKEGDRLVITVEDNGVGMPEEKLEKLL-------EELSSKGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIR 439
|
....
gi 492092276 561 LPIR 564
Cdd:COG2972 440 IPLE 443
|
|
| PRK13558 |
PRK13558 |
bacterio-opsin activator; Provisional |
160-310 |
6.73e-04 |
|
bacterio-opsin activator; Provisional
Pssm-ID: 237426 [Multi-domain] Cd Length: 665 Bit Score: 42.52 E-value: 6.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 160 DNTARKQEEEAQALLDQRLRDqqfytRSLIESNI-----DAlmmTDPQGIISDVNKQMMALTGRTRDELIGAPCKnFFTD 234
Cdd:PRK13558 131 DTEARMPISDLTVESDRRLKE-----RALDEAPVgitiaDA---TLPDEPLIYINDAFERITGYSPDEVLGRNCR-FLQG 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 235 PASADAAI----KRVLSEHKVSDYELTVRAyDGTETVVSYNAATFHDRDRKLKGVFAAARDVTERKRFERTLEEKNVELE 310
Cdd:PRK13558 202 EDTNEERVaelrEAIDEERPTSVELRNYRK-DGSTFWNQVDIAPIRDEDGTVTHYVGFQTDVTERKEAELALQRERRKLQ 280
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
304-571 |
8.36e-04 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 42.23 E-value: 8.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 304 EKNVelehasHMKSEFLATMSHELRTPLNAVIGFSEALKDgmvGDMTDAQRRYIGDIFNSGQHLLSLINDILDLSKVEAG 383
Cdd:PRK10618 444 EKNQ------QARKAFLQNIGDELKQPLQSLAQLAAQLRQ---TSDEEQQQPELDQLAEQSDVLVRLVDNIQLLNMLETQ 514
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 384 MMTLELEP------VDleellsnslLIVREQ-AALQRIQLKL----ETEAD---FGllelDRRKTKQIVYNLLANAVKfS 449
Cdd:PRK10618 515 DWKPEQELfslqdlID---------EVLPEVlPAIKRKGLQLlihnHLKAEqlrIG----DRDALRKILLLLLNYAIT-T 580
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 450 EPGGWVTLAVRQvsfaqagviegdwpahtfplpSSEYEQFLELSVSDTGIGIAQSDMNKL---FKAFSQIDsglaRKFEG 526
Cdd:PRK10618 581 TAYGKITLEVDQ---------------------DESSPDRLTIRILDTGAGVSIKELDNLhfpFLNQTQGD----RYGKA 635
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 492092276 527 TGLGLAMVKQLTELHGGCVAVASVKDLGARFVVWLPIRP--PECEEA 571
Cdd:PRK10618 636 SGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKMLAadPEVEEE 682
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
319-542 |
1.30e-03 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 41.56 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 319 FLATMSHELRTPLNAVIGFSEALKdgMVGDmtDAQRRyigdifnsgQHLLS-----------LINDILDLSKVEAGMMTL 387
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTEVAQ--LSDD--DPQAR---------KKALLqlhagidratrLVDQLLTLSRLDSLDNLQ 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 388 ELEPVDLEELLSNSLLIVREQAALQRIQLKLETEAD----FG---LLELdrrktkqIVYNLLANAVKFSEPGGWVTLAVR 460
Cdd:PRK10337 307 DVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHpvirTGqplLLSL-------LVRNLLDNAIRYSPQGSVVDVTLN 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 461 qvsfaqagviegdwpAHTFplpsseyeqflelSVSDTGIGIAQSDMNKLFKAF----SQIDSglarkfeGTGLGLAMVKQ 536
Cdd:PRK10337 380 ---------------ARNF-------------TVRDNGPGVTPEALARIGERFyrppGQEAT-------GSGLGLSIVRR 424
|
....*.
gi 492092276 537 LTELHG 542
Cdd:PRK10337 425 IAKLHG 430
|
|
| PRK11359 |
PRK11359 |
cyclic-di-GMP phosphodiesterase; Provisional |
37-303 |
5.28e-03 |
|
cyclic-di-GMP phosphodiesterase; Provisional
Pssm-ID: 183097 [Multi-domain] Cd Length: 799 Bit Score: 39.75 E-value: 5.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 37 DAIFNSAYFSSIA----TDEHGVIQIFNVGAERMLGYHSEDV----VDKITPADISdPAELiiraAALSHElntpiTPGF 108
Cdd:PRK11359 11 DGIFFPALEQNMMgavlINENDEVLFFNPAAEKLWGYKREEVignnIDMLIPRDLR-PAHP----EYIRHN-----REGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 109 EALVFKASRgiediyELTYIRKDGSRLSAMVSVTSLrdSAETIIGYLLIGTDntarkqeeeaqALLDQRLRDQqfyTRSL 188
Cdd:PRK11359 81 KARVEGMSR------ELQLEKKDGSKIWTRFALSKV--SAEGKVYYLALVRD-----------ASVEMAQKEQ---TRQL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 189 IES--NID-ALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFTDPASADAAIKRVLS----EHKVSDyELTVRAY 261
Cdd:PRK11359 139 IIAvdHLDrPVIVLDPERRIVQCNRAFTEMFGYCISEASGMQPDTLLNIPEFPADNRIRLQQllwkTARDQD-EFLLLTR 217
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 492092276 262 DGTETVVSYNAATFHDRDRKLKGVFAAARDVTERKRFeRTLE 303
Cdd:PRK11359 218 TGEKIWIKASISPVYDVLAHLQNLVMTFSDITEERQI-RQLE 258
|
|
| PAC |
smart00086 |
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif ... |
123-164 |
6.98e-03 |
|
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif occurs C-terminal to a subset of all known PAS motifs. It is proposed to contribute to the PAS domain fold.
Pssm-ID: 197509 Cd Length: 43 Bit Score: 34.85 E-value: 6.98e-03
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 492092276 123 YELTYIRKDGSRLSAMVSVTSLRDSAETIIGYLLIGTDNTAR 164
Cdd:smart00086 2 VEYRLRRKDGSYIWVLVSASPIRDEDGEVEGILGVVRDITER 43
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
34-565 |
9.47e-03 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 38.73 E-value: 9.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 34 ALQDAIFNSAYFSSIATDEHGVIQIFNVGAERMLGYHSEDVVDKITPADISDPAELIIRAAALSHELNTPITPGFEALVF 113
Cdd:COG3920 23 LLLAAALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALAL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 114 KASRGIEDIYELTYIRKdgsRLSAMVSVTSLRDSAETIIGYLLIGTDNTARKQEEEAQALLDQRLRDQQFYTRSLIESNI 193
Cdd:COG3920 103 LLAALAGLLLLAALLLL---RLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 194 DALMMTDPQGIISDVNKQMMALTGRTRDELIGAPCKNFFTDPASADAAIKRVLSEHKVSDYELTVRAYDGTETVVSYNAA 273
Cdd:COG3920 180 LLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 274 TFHDRDRKLKGVFAAARDVTERKRFERTLEEKNVELEHAshmksefLATMSHELRTPLNAVIGF----SEALKDGMVGDM 349
Cdd:COG3920 260 LLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELL-------LRELHHRVKNNLQVVSSLlrlqARRADDPEAREA 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 350 -TDAQRRyigdIfnsgqHLLSLINDIL----DLSKVEAG-MMTLELEPVdleellsnsllivREQAALQRIQLKLETEAd 423
Cdd:COG3920 333 lEESQNR----I-----QALALVHELLyqseDWEGVDLRdYLRELLEPL-------------RDSYGGRGIRIELDGPD- 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492092276 424 fglLELDRRKTKQ---IVYNLLANAVKF---SEPGGWVTLAVRQVsfaqagviegdwpahtfplpsseyEQFLELSVSDT 497
Cdd:COG3920 390 ---VELPADAAVPlglILNELVTNALKHaflSGEGGRIRVSWRRE------------------------DGRLRLTVSDN 442
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492092276 498 GIGIAQSdmnklfkafsqidsglARKFEGTGLGLAMVKQLTELHGGCVAVASvkDLGARFVVWLPIRP 565
Cdd:COG3920 443 GVGLPED----------------VDPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFPLAE 492
|
|
| |
