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Conserved domains on  [gi|492255698|ref|WP_005791915|]
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MULTISPECIES: NAD-dependent deacylase [Bacteroides]

Protein Classification

SIR2 family NAD-dependent protein deacylase( domain architecture ID 10105453)

SIR2 family NAD-dependent protein deacylase such as NAD-dependent deacetylase, which catalyzes NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
2-226 7.53e-109

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


:

Pssm-ID: 238703  Cd Length: 224  Bit Score: 312.22  E-value: 7.53e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEKDF-Q 80
Cdd:cd01412    1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRAQPNPAHLALAELERRLpN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  81 VTIVTQNIDNLHERAGSSHIIHLHGELTKVCSSRDPNNPHYIkelkPEEFEVKIGDLAGDGSQLRPFIVWFGESVP-EIE 159
Cdd:cd01412   81 VLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENN----EEIPEEELPRCPKCGGLLRPGVVWFGESLPlALL 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492255698 160 TAIDWVEKADVFVIIGTSMNVYPAAGLLNYV-PRNAEIYLIDPKPVDVhSSRPIHVIQKGASEGVAEL 226
Cdd:cd01412  157 EAVEALAKADLFLVIGTSGVVYPAAGLPEEAkERGARVIEINPEPTPL-SPIADFAFRGKAGEVLPAL 223
 
Name Accession Description Interval E-value
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
2-226 7.53e-109

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 312.22  E-value: 7.53e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEKDF-Q 80
Cdd:cd01412    1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRAQPNPAHLALAELERRLpN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  81 VTIVTQNIDNLHERAGSSHIIHLHGELTKVCSSRDPNNPHYIkelkPEEFEVKIGDLAGDGSQLRPFIVWFGESVP-EIE 159
Cdd:cd01412   81 VLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENN----EEIPEEELPRCPKCGGLLRPGVVWFGESLPlALL 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492255698 160 TAIDWVEKADVFVIIGTSMNVYPAAGLLNYV-PRNAEIYLIDPKPVDVhSSRPIHVIQKGASEGVAEL 226
Cdd:cd01412  157 EAVEALAKADLFLVIGTSGVVYPAAGLPEEAkERGARVIEINPEPTPL-SPIADFAFRGKAGEVLPAL 223
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
1-231 6.81e-108

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 310.57  E-value: 6.81e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   1 MKNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEK-DF 79
Cdd:PRK00481  13 AKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFYNERRRQLLDAKPNAAHRALAELEKlGK 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  80 QVTIVTQNIDNLHERAGSSHIIHLHGELTKVCSSRDPNNPHYIKELKPEEFEVKigdlaGDGSQLRPFIVWFGESVPE-- 157
Cdd:PRK00481  93 LVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEPPRCP-----KCGGILRPDVVLFGEMLPEla 167
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492255698 158 IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVP-RNAEIYLIDPKPVDVHSSRPIhVIQKGASEGVAELREKLL 231
Cdd:PRK00481 168 IDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAReHGAKTVEINLEPTPLDSLFDL-VIHGKAGEVVPELVEELL 241
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
1-228 4.52e-104

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 300.92  E-value: 4.52e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   1 MKNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEKD-F 79
Cdd:COG0846   14 AKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLRDAEPNAAHRALAELEKAgK 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  80 QVTIVTQNIDNLHERAGSSHIIHLHGELTKVCSSRDPNnpHYIKELKPEEFEVKIGDLAGD-GSQLRPFIVWFGESVPE- 157
Cdd:COG0846   94 LVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGK--RYDLEDVLEDLEGELPPRCPKcGGLLRPDVVWFGEMLPEe 171
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492255698 158 -IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPRN-AEIYLIDPKPVDVHSSRPIhVIQKGASEGVAELRE 228
Cdd:COG0846  172 aLERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAgAPLVEINPEPTPLDSLADL-VIRGDAGEVLPALVE 243
prot_deacyl_CobB NF040867
NAD-dependent protein deacetylase;
2-203 2.94e-64

NAD-dependent protein deacetylase;


Pssm-ID: 468804  Cd Length: 242  Bit Score: 199.72  E-value: 2.94e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEKDFQV 81
Cdd:NF040867  11 RHAIAFTGAGISTESGIPTFRGPDGLWRRYDPEELATIEAFERDPKLVWEFYRWRMEKLFDAKPNPAHYALAELERMGIL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  82 -TIVTQNIDNLHERAGSSHIIHLHGELTKV-CSSRDPNNPhyIKElkPEEFEVKIGDL---AGDGSQLRPFIVWFGESVP 156
Cdd:NF040867  91 kAVITQNVDGLHQRAGSRNVIELHGNMRRVrCTSCGRTYD--LEE--VLRKIDKGELPprcPECGGLLRPDVVLFGEPLP 166
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 492255698 157 E--IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPRN-AEIYLIDPKP 203
Cdd:NF040867 167 DdaLEEAFELAERSDVVLVVGSSLTVYPAAYLPYIAKENgGKLIIINPEE 216
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
9-182 2.54e-56

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 177.44  E-value: 2.54e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698    9 GAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELV---THFYNERRKQLL-EVEPNRGHELLAELE-KDFQVTI 83
Cdd:pfam02146   1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVwdpEPFYNIARELLPgEAQPNPAHYFIAKLEdKGKLLRL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   84 VTQNIDNLHERAGSSHIIHLHGELTKV-CSsrDPNNPHYIKELKPEEFEVKIGDLAGDGSQLRPFIVWFGESVPE-IETA 161
Cdd:pfam02146  81 ITQNIDGLHERAGSKKVVELHGSFAKArCV--SCHQKYTGETLYERIRPEKVPHCPQCGGLLKPDIVFFGENLPDkFHRA 158
                         170       180
                  ....*....|....*....|.
gi 492255698  162 IDWVEKADVFVIIGTSMNVYP 182
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
 
Name Accession Description Interval E-value
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
2-226 7.53e-109

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 312.22  E-value: 7.53e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEKDF-Q 80
Cdd:cd01412    1 RRVVVLTGAGISAESGIPTFRDADGLWARFDPEELATPEAFARDPELVWEFYNWRRRKALRAQPNPAHLALAELERRLpN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  81 VTIVTQNIDNLHERAGSSHIIHLHGELTKVCSSRDPNNPHYIkelkPEEFEVKIGDLAGDGSQLRPFIVWFGESVP-EIE 159
Cdd:cd01412   81 VLLITQNVDGLHERAGSRNVIELHGSLFRVRCSSCGYVGENN----EEIPEEELPRCPKCGGLLRPGVVWFGESLPlALL 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492255698 160 TAIDWVEKADVFVIIGTSMNVYPAAGLLNYV-PRNAEIYLIDPKPVDVhSSRPIHVIQKGASEGVAEL 226
Cdd:cd01412  157 EAVEALAKADLFLVIGTSGVVYPAAGLPEEAkERGARVIEINPEPTPL-SPIADFAFRGKAGEVLPAL 223
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
1-231 6.81e-108

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 310.57  E-value: 6.81e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   1 MKNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEK-DF 79
Cdd:PRK00481  13 AKRIVVLTGAGISAESGIPDFRSANGLWEEHRPEDVASPEGFARDPELVWKFYNERRRQLLDAKPNAAHRALAELEKlGK 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  80 QVTIVTQNIDNLHERAGSSHIIHLHGELTKVCSSRDPNNPHYIKELKPEEFEVKigdlaGDGSQLRPFIVWFGESVPE-- 157
Cdd:PRK00481  93 LVTVITQNIDGLHERAGSKNVIELHGSLLRARCTKCGQTYDLDEYLKPEPPRCP-----KCGGILRPDVVLFGEMLPEla 167
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492255698 158 IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVP-RNAEIYLIDPKPVDVHSSRPIhVIQKGASEGVAELREKLL 231
Cdd:PRK00481 168 IDEAYEALEEADLFIVIGTSLVVYPAAGLPYEAReHGAKTVEINLEPTPLDSLFDL-VIHGKAGEVVPELVEELL 241
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
1-228 4.52e-104

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 300.92  E-value: 4.52e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   1 MKNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEKD-F 79
Cdd:COG0846   14 AKRIVVLTGAGISAESGIPDFRGPDGLWEKYDPEEVASPEAFRRDPELVWAFYNERRRLLRDAEPNAAHRALAELEKAgK 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  80 QVTIVTQNIDNLHERAGSSHIIHLHGELTKVCSSRDPNnpHYIKELKPEEFEVKIGDLAGD-GSQLRPFIVWFGESVPE- 157
Cdd:COG0846   94 LVFVITQNVDGLHQRAGSKNVIELHGSLHRLRCTKCGK--RYDLEDVLEDLEGELPPRCPKcGGLLRPDVVWFGEMLPEe 171
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492255698 158 -IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPRN-AEIYLIDPKPVDVHSSRPIhVIQKGASEGVAELRE 228
Cdd:COG0846  172 aLERALEALAEADLFLVIGTSLVVYPAAGLPEYAKRAgAPLVEINPEPTPLDSLADL-VIRGDAGEVLPALVE 243
SIR2-fam cd01407
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ...
2-216 1.53e-82

SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.


Pssm-ID: 238698  Cd Length: 218  Bit Score: 245.56  E-value: 1.53e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVA-TPEGYARDPELVTHFYNERRKqLLEVEPNRGHELLAELEKDFQ 80
Cdd:cd01407    1 KRIVVLTGAGISTESGIPDFRSPGGLWARLDPEELAfSPEAFRRDPELFWGFYRERRY-PLNAQPNPAHRALAELERKGK 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  81 -VTIVTQNIDNLHERAGSSHIIHLHGELTKV----CSSRDPNNphyikELKPEEFEVKIGDLAGDGSQLRPFIVWFGESV 155
Cdd:cd01407   80 lKRVITQNVDGLHQRAGSPKVIELHGSLFRVrctkCGKEYPRD-----ELQADIDREEVPRCPKCGGLLRPDVVFFGESL 154
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492255698 156 P-EIETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPRN-AEIYLIDPKPVDvHSSRPIHVIQ 216
Cdd:cd01407  155 PeELDEAAEALAKADLLLVIGTSLQVYPAAGLPLYAPERgAPVVIINLEPTP-ADRKADLVIL 216
SIR2 cd00296
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
2-215 1.13e-69

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


Pssm-ID: 238184 [Multi-domain]  Cd Length: 222  Bit Score: 212.97  E-value: 1.13e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAG-GLWDRYPVEQVA-TPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEKDF 79
Cdd:cd00296    1 KRVVVFTGAGISTESGIPDFRGLGtGLWTRLDPEELAfSPEAFRRDPELFWLFYKERRYTPLDAKPNPAHRALAELERKG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  80 Q-VTIVTQNIDNLHERAGSS--HIIHLHGELTKVCSSRDPNNPHYIKELKPEefevKIGDLAGDGSQLRPFIVWFGESVP 156
Cdd:cd00296   81 KlKRIITQNVDGLHERAGSRrnRVIELHGSLDRVRCTSCGKEYPRDEVLERE----KPPRCPKCGGLLRPDVVDFGEALP 156
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492255698 157 E--IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPRN-AEIYLIDPKPVDvHSSRPIHVI 215
Cdd:cd00296  157 KewFDRALEALLEADLVLVIGTSLTVYPAARLLLRAPERgAPVVIINREPTP-ADALKKADL 217
PTZ00408 PTZ00408
NAD-dependent deacetylase; Provisional
4-186 6.76e-66

NAD-dependent deacetylase; Provisional


Pssm-ID: 240405  Cd Length: 242  Bit Score: 203.90  E-value: 6.76e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   4 LVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLL--EVEPNRGHELLAELEKDF-- 79
Cdd:PTZ00408   7 ITILTGAGISAESGISTFRDGNGLWENHRVEDVATPDAFLRNPALVQRFYNERRRALLssSVKPNKAHFALAKLEREYrg 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  80 -QVTIVTQNIDNLHERAGSSHIIHLHGELTKVCSSRDPNNPHYIKELKPEEFEVKIgdlAGDGSQLRPFIVWFGES---V 155
Cdd:PTZ00408  87 gKVVVVTQNVDNLHERAGSTHVLHMHGELLKVRCTATGHVFDWTEDVVHGSSRCKC---CGCVGTLRPHIVWFGEMplyM 163
                        170       180       190
                 ....*....|....*....|....*....|.
gi 492255698 156 PEIETAIDwveKADVFVIIGTSMNVYPAAGL 186
Cdd:PTZ00408 164 DEIESVMS---KTDLFVAVGTSGNVYPAAGF 191
prot_deacyl_CobB NF040867
NAD-dependent protein deacetylase;
2-203 2.94e-64

NAD-dependent protein deacetylase;


Pssm-ID: 468804  Cd Length: 242  Bit Score: 199.72  E-value: 2.94e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEKDFQV 81
Cdd:NF040867  11 RHAIAFTGAGISTESGIPTFRGPDGLWRRYDPEELATIEAFERDPKLVWEFYRWRMEKLFDAKPNPAHYALAELERMGIL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  82 -TIVTQNIDNLHERAGSSHIIHLHGELTKV-CSSRDPNNPhyIKElkPEEFEVKIGDL---AGDGSQLRPFIVWFGESVP 156
Cdd:NF040867  91 kAVITQNVDGLHQRAGSRNVIELHGNMRRVrCTSCGRTYD--LEE--VLRKIDKGELPprcPECGGLLRPDVVLFGEPLP 166
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 492255698 157 E--IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPRN-AEIYLIDPKP 203
Cdd:NF040867 167 DdaLEEAFELAERSDVVLVVGSSLTVYPAAYLPYIAKENgGKLIIINPEE 216
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
9-182 2.54e-56

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 177.44  E-value: 2.54e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698    9 GAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELV---THFYNERRKQLL-EVEPNRGHELLAELE-KDFQVTI 83
Cdd:pfam02146   1 GAGISTESGIPDFRSDDGLYAKLAPEELASPEAFFSNPELVwdpEPFYNIARELLPgEAQPNPAHYFIAKLEdKGKLLRL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   84 VTQNIDNLHERAGSSHIIHLHGELTKV-CSsrDPNNPHYIKELKPEEFEVKIGDLAGDGSQLRPFIVWFGESVPE-IETA 161
Cdd:pfam02146  81 ITQNIDGLHERAGSKKVVELHGSFAKArCV--SCHQKYTGETLYERIRPEKVPHCPQCGGLLKPDIVFFGENLPDkFHRA 158
                         170       180
                  ....*....|....*....|.
gi 492255698  162 IDWVEKADVFVIIGTSMNVYP 182
Cdd:pfam02146 159 YEDLEEADLLIVIGTSLKVYP 179
SIR2_Af2 cd01413
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ...
2-205 3.38e-53

SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.


Pssm-ID: 238704  Cd Length: 222  Bit Score: 171.01  E-value: 3.38e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEKDFQV 81
Cdd:cd01413    5 RKTVVLTGAGISTESGIPDFRSPDGLWKKYDPEEVASIDYFYRNPEEFWRFYKEIILGLLEAQPNKAHYFLAELEKQGII 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  82 -TIVTQNIDNLHERAGSSHIIHLHGELTKV----CSSrdpnnPHYIKELKPEefevKIGDL---AGDGSQLRPFIVWFGE 153
Cdd:cd01413   85 kAIITQNIDGLHQRAGSKNVIELHGTLQTAycvnCGS-----KYDLEEVKYA----KKHEVprcPKCGGIIRPDVVLFGE 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 492255698 154 SVPE--IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPRN-AEIYLI--DPKPVD 205
Cdd:cd01413  156 PLPQalLREAIEAAKEADLFIVLGSSLVVYPANLLPLIAKENgAKLVIVnaDETPFD 212
SIR2H cd01411
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ...
2-204 2.59e-44

SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238702  Cd Length: 225  Bit Score: 148.28  E-value: 2.59e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAGGLWD---RYPVEQVATPEGYARDPELVTHFYNERrkqLL--EVEPNRGHELLAELE 76
Cdd:cd01411    9 KRIVFFTGAGVSTASGIPDYRSKNGLYNeiyKYSPEYLLSHDFLEREPEKFYQFVKEN---LYfpDAKPNIIHQKMAELE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  77 KDFQVTIVTQNIDNLHERAGSSHIIHLHGELTKV-CssrdpNNPHyikELKPEEFEVKIGDLAGDGSQLRPFIVWFGESV 155
Cdd:cd01411   86 KMGLKAVITQNIDGLHQKAGSKNVVEFHGSLYRIyC-----TVCG---KTVDWEEYLKSPYHAKCGGVIRPDIVLYEEML 157
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 492255698 156 PE--IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPRNAEIYLIDPKPV 204
Cdd:cd01411  158 NEsvIEEAIQAIEKADLLVIVGTSFVVYPFAGLIDYRQAGANLIAINKEPT 208
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
2-213 1.34e-30

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238701  Cd Length: 206  Bit Score: 112.39  E-value: 1.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAGGLWDRYPVEQVATpegyardpelvthfynERRKQLLEVEPNRGHELLAELEKDFQV 81
Cdd:cd01410    1 KHLVVFTGAGISTSAGIPDFRGPNGVWTLLPEDKGRR----------------RFSWRFRRAEPTLTHMALVELERAGLL 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  82 T-IVTQNIDNLHERAGSS--HIIHLHGELTK-VCSSRDPNNPhyikelKPEEFEvKIGDLAGD------GSQLRPFIVWF 151
Cdd:cd01410   65 KfVISQNVDGLHLRSGLPreKLSELHGNMFIeVCKSCGPEYV------RDDVVE-TRGDKETGrrchacGGILKDTIVDF 137
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492255698 152 GESVPE--IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPRN-AEIYLID--PKPVDVHSSRPIH 213
Cdd:cd01410  138 GERLPPenWMGAAAAACRADLFLCLGTSLQVTPAANLPLKAARAgGRLVIVNlqPTPKDKLADLVIH 204
PRK14138 PRK14138
NAD-dependent deacetylase; Provisional
5-199 3.26e-30

NAD-dependent deacetylase; Provisional


Pssm-ID: 172627 [Multi-domain]  Cd Length: 244  Bit Score: 112.22  E-value: 3.26e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   5 VVLSGAGMSAESGISTFRDAGGLWDRYPvEQVATPEGYARDPELVTHFYNERRKQLLEVEPNRGHELLAELEKDFQV-TI 83
Cdd:PRK14138  15 VTLTGAGISTPSGIPDFRGPQGIYKKYP-QNVFDIDFFYSHPEEFYRFAKEGIFPMLEAKPNLAHVLLAKLEEKGLIeAV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  84 VTQNIDNLHERAGSSHIIHLHGELTKV----CSSRdpnnphYIKELKPEEFEVKIGDLAGD-GSQLRPFIVWFGESVPE- 157
Cdd:PRK14138  94 ITQNIDRLHQKAGSKKVIELHGNVEEYycvrCGKR------YTVEDVIEKLEKSDVPRCDDcSGLIRPNIVFFGEALPQd 167
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 492255698 158 -IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPRNAEIYLI 199
Cdd:PRK14138 168 aLREAIRLSSKASLMIVMGSSLVVYPAAELPLITVRSGGKLVI 210
PTZ00409 PTZ00409
Sir2 (Silent Information Regulator) protein; Provisional
2-192 4.68e-30

Sir2 (Silent Information Regulator) protein; Provisional


Pssm-ID: 173599 [Multi-domain]  Cd Length: 271  Bit Score: 112.71  E-value: 4.68e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAG-GLWDRYPVEQVATPEGYARDPELVTHFYNERRKQLlEVEPNRGHELLAELEK-DF 79
Cdd:PTZ00409  29 KYVVALTGSGTSAESNIPSFRGPSsSIWSKYDPKIYGTIWGFWKYPEKIWEVIRDISSDY-EIELNPGHVALSTLESlGY 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  80 QVTIVTQNIDNLHERAGSSHIIHLHGEL--TKVCSSRD---------PNNPHYIKELKPEefevkigdlAGDGSQLRPFI 148
Cdd:PTZ00409 108 LKFVVTQNVDGLHEESGNTKVIPLHGSVfeARCCTCRKtiqlnkimlQKTSHFMHQLPPE---------CPCGGIFKPNV 178
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 492255698 149 VWFGESVPE--IETAIDWVEKADVFVIIGTSMNVYPAAGLLNYVPR 192
Cdd:PTZ00409 179 ILFGEVIPKslLKQAEKEIDKCDLLLVVGTSSSVSTATNLCYRAHR 224
SIRT4 cd01409
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ...
2-183 4.47e-28

SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238700  Cd Length: 260  Bit Score: 107.00  E-value: 4.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAGGLWDRYPveQVATPEGYARDPelvthfyNERRK----------QLLEVEPNRGHEL 71
Cdd:cd01409    9 RRLLVLTGAGISTESGIPDYRSEGGLYSRTF--RPMTHQEFMRSP-------AARQRywarsfvgwpRFSAAQPNAAHRA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  72 LAELEKDFQVT-IVTQNIDNLHERAGSSHIIHLHGELTKV----CSSRDPN----------NPHYIK-----------EL 125
Cdd:cd01409   80 LAALEAAGRLHgLITQNVDGLHTKAGSRNVVELHGSLHRVvclsCGFRTPRaelqdrlealNPGFAEqaagqapdgdvDL 159
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492255698 126 KPEEFE-VKIGDLAGDGSQLRPFIVWFGESVP--EIETAIDWVEKADVFVIIGTSMNVYPA 183
Cdd:cd01409  160 EDEQVAgFRVPECERCGGVLKPDVVFFGENVPrdRVVTAAARLAEADALLVLGSSLMVYSG 220
PRK05333 PRK05333
NAD-dependent protein deacetylase;
4-181 1.56e-27

NAD-dependent protein deacetylase;


Pssm-ID: 235415  Cd Length: 285  Bit Score: 106.30  E-value: 1.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   4 LVVLSGAGMSAESGISTFRDAGGLWDRYPVEQV-------ATPEGY-ARDPELVTHFYNERrkqllevePNRGHELLAEL 75
Cdd:PRK05333  22 LFVLTGAGISTDSGIPDYRDRNGQWKRSPPITYqafmgsdAARRRYwARSMVGWPVFGRAQ--------PNAAHHALARL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  76 EKDFQVT-IVTQNIDNLHERAGSSHIIHLHGELTKV----CSSRDPNNP--HYIKELKPEEFEVKIGDLA-GD------- 140
Cdd:PRK05333  94 GAAGRIErLVTQNVDGLHQRAGSRDVIELHGRLDGVrcmgCGARHPRAEiqHVLEAANPEWLALEAAPAPdGDadlewaa 173
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 492255698 141 ------------GSQLRPFIVWFGESVPE--IETAIDWVEKADVFVIIGTSMNVY 181
Cdd:PRK05333 174 fdhfrvpacpacGGILKPDVVFFGENVPRerVAAARAALDAADAVLVVGSSLMVY 228
SIRT1 cd01408
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ...
2-226 1.94e-20

SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.


Pssm-ID: 238699  Cd Length: 235  Bit Score: 86.15  E-value: 1.94e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRDAG-GLWDRYPVEQVATPEG------YARDPELvthFYNeRRKQLL--EVEPNRGHELL 72
Cdd:cd01408    1 KKIVVLVGAGISTSAGIPDFRSPGtGLYANLARYNLPYPEAmfdisyFRKNPRP---FYA-LAKELYpgQFKPSVAHYFI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  73 AELE-KDFQVTIVTQNIDNLHERAGSSH--IIHLHGELTK----VCSSRDPNNphyikELKPEEFEVKIGDLAGDGSQLR 145
Cdd:cd01408   77 KLLEdKGLLLRNYTQNIDTLERVAGVPDdrIIEAHGSFATahciKCKHKYPGD-----WMREDIFNQEVPKCPRCGGLVK 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698 146 PFIVWFGESVPE-----IETAIDWvekADVFVIIGTSMNVYPAAGLLNYVPRNAEIYLIDPKPVDVHSSRPIHVIQKGAS 220
Cdd:cd01408  152 PDIVFFGESLPSrffshMEEDKEE---ADLLIVIGTSLKVAPFASLPSRVPSEVPRVLINREPVGHLGKRPFDVALLGDC 228

                 ....*..
gi 492255698 221 E-GVAEL 226
Cdd:cd01408  229 DdGVREL 235
PTZ00410 PTZ00410
NAD-dependent SIR2; Provisional
1-193 9.63e-10

NAD-dependent SIR2; Provisional


Pssm-ID: 185600  Cd Length: 349  Bit Score: 57.57  E-value: 9.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   1 MKNLVVLSGAGMSAESGISTFRDA-GGLWDRYPVEQVATPEG------YARDPELvthFYNERRKQLL---EVEPNRGHE 70
Cdd:PTZ00410  29 VTKILVMVGAGISVAAGIPDFRSPhTGIYAKLGKYNLNSPTDafsltlLREKPEV---FYSIAREMDLwpgHFQPTAVHH 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698  71 LLAELEKDFQV-TIVTQNIDNLHERAG--SSHIIHLHGELTKVcSSRDPNNPHYIKELKPEEFEVKIGDLAGDGSQLRPF 147
Cdd:PTZ00410 106 FIRLLADEGRLlRCCTQNIDGLERAAGvpPSLLVEAHGSFSAA-SCIECHTPYDIEQAYLEARSGKVPHCSTCGGIVKPD 184
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 492255698 148 IVWFGESVPE--IETAIDwVEKADVFVIIGTSMNVYPAAGLLNYVPRN 193
Cdd:PTZ00410 185 VVFFGENLPDafFNVHHD-IPEAELLLIIGTSLQVHPFALLACVVPKD 231
SIR2-like cd01406
Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key ...
2-95 3.37e-05

Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation.


Pssm-ID: 238697 [Multi-domain]  Cd Length: 242  Bit Score: 43.54  E-value: 3.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492255698   2 KNLVVLSGAGMSAESGISTFRD-AGGLWDR------YPVEQVATPEGYArdpELVTHFYNE------------RRKQLLE 62
Cdd:cd01406    1 GRVVIFVGAGVSVSSGLPDWKTlLDEIASElgleidGYSVEAKDENDYL---ELAELLEKEfgtigikinavlEEKTRPD 77
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 492255698  63 VEPNRGHELLAELEKDFQ--VTIVTQNIDNLHERA 95
Cdd:cd01406   78 FEPSPLHELLLRLFINNEgdVIIITTNYDRLLETA 112
TPP_enzyme_M pfam00205
Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a ...
165-226 2.82e-03

Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a 2-fold Rossman fold.


Pssm-ID: 425523 [Multi-domain]  Cd Length: 137  Bit Score: 36.77  E-value: 2.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492255698  165 VEKADVFVIIGTSMNVYPAAGLLNYVPRNAEIYLIDPKPVDVHSSRPIHV-IQKGASEGVAEL 226
Cdd:pfam00205  75 LEEADLVLAVGARFDDIRTTGKLPEFAPDAKIIHIDIDPAEIGKNYPVDVpIVGDAKETLEAL 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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