|
Name |
Accession |
Description |
Interval |
E-value |
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
127-422 |
2.10e-29 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 116.93 E-value: 2.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 127 SIEKEDLKDAMAGWIIFLYIALLLTIIVINVWVFYRNMRPLYVLLHWLDKYRIGKVNEPLQNNTRVSEFRKLNEAAVRYA 206
Cdd:COG0642 21 ALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 207 ERSEQMFEQQKQFIGNASHEMQTPLAICRNRLEMLMEDenLSESQLEELMKTHQTLEHITKLNKSLLLLSKIENGQFT-D 285
Cdd:COG0642 101 LLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE--LDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLElE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 286 TVQVEVNKLLRQYLEDYKEVYQYREIITSIE-EEGVFYLTINETLAVVLLTNLLKNAFVHNMDGGHIRIVITPHSVMFC- 363
Cdd:COG0642 179 PEPVDLAELLEEVVELFRPLAEEKGIELELDlPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRi 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492447620 364 ---NTGAAQPLDAR-RIFERFYQGKK--KEGSTGLGLAIADTICKMQALRLCYEYKSGEH-CFTLY 422
Cdd:COG0642 259 sveDTGPGIPPEDLeRIFEPFFRTDPsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGtTFTVT 324
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
121-421 |
4.64e-15 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 76.66 E-value: 4.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 121 LTVATPSIEKEDLKDAMAGWIIFLYIALLLTIIVINVWVFYRNMRPLYVLL--------HWLDkYRIGKVNEPlqnntrv 192
Cdd:TIGR01386 146 ITVALDINAHTHLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSavaarispESLD-QRLDPSRAP------- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 193 SEFRKLNEAAVRYAERSEQMFEQQKQFIGNASHEMQTPL---------AICRNRleMLMEDENLSESQLEElmkthqtLE 263
Cdd:TIGR01386 218 AELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLtnllgqtqvALSQPR--TGEEYREVLESNLEE-------LE 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 264 HITKLNKSLLLLSKIENGQFT-DTVQVEVNKLLRQYLEDYKEVYQYREIitSIEEEGVFYLTINETLAVVLLTNLLKNAF 342
Cdd:TIGR01386 289 RLSRMVSDMLFLARADNGQLAlERVRLDLAAELAKVAEYFEPLAEERGV--RIRVEGEGLVRGDPQMFRRAISNLLSNAL 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 343 VHNMDGGHIRIVITPHSVMFC----NTGAAQPLDAR-RIFERFYQG----KKKEGSTGLGLAIADTICKMQALRLCYEYK 413
Cdd:TIGR01386 367 RHTPDGGTITVRIERRSDEVRvsvsNPGPGIPPEHLsRLFDRFYRVdparSNSGEGTGLGLAIVRSIMEAHGGRASAESP 446
|
....*...
gi 492447620 414 SGEHCFTL 421
Cdd:TIGR01386 447 DGKTRFIL 454
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
140-408 |
2.96e-14 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 74.30 E-value: 2.96e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 140 WIIFLYIALLLTIivinvWVFYRNMRPLYVLLHWLdKYRIGKVNEPLqNNTRV-SEFRKLNEAAVRYAERSEQMFEQQKQ 218
Cdd:PRK10337 167 WLVALPIMLIILM-----VLLGRELAPLKKLALAL-RMRDPDSETPL-NATGVpSEVRPLVEALNQLFARTHAMMVRERR 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 219 FIGNASHEMQTPLAICRNRLE---MLMEDENLSESQLEELmktHQTLEHITKLNKSLLLLSKIENG-QFTDTVQVEVNKL 294
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTEvaqLSDDDPQARKKALLQL---HAGIDRATRLVDQLLTLSRLDSLdNLQDVAEIPLEDL 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 295 LRQYLED-YKEVYQYR-EIITSIEEEGVFyLTINETLAVVLLTNLLKNAFVHNMDGGHIRIVITPHSVMFCNTGAAQPLD 372
Cdd:PRK10337 317 LQSAVMDiYHTAQQAGiDVRLTLNAHPVI-RTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRDNGPGVTPE 395
|
250 260 270
....*....|....*....|....*....|....*....
gi 492447620 373 A-RRIFERFYQ--GKKKEGStGLGLAIADTICKMQALRL 408
Cdd:PRK10337 396 AlARIGERFYRppGQEATGS-GLGLSIVRRIAKLHGMNV 433
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
333-422 |
6.78e-12 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 61.46 E-value: 6.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 333 LLTNLLKNAFVHNMDGGHIRIVI--TPHSVMFC--NTGAAQPLDAR-RIFERFYQGKK--KEGSTGLGLAIADTICKMQA 405
Cdd:cd00075 4 VLSNLLDNALKYSPPGGTIEISLrqEGDGVVLEveDNGPGIPEEDLeRIFERFYRGDKsrEGGGTGLGLAIVRRIVEAHG 83
|
90
....*....|....*...
gi 492447620 406 LRLCYEYKSGEH-CFTLY 422
Cdd:cd00075 84 GRITVESEPGGGtTFTVT 101
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
333-422 |
3.84e-10 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 56.89 E-value: 3.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 333 LLTNLLKNAFVHNMDGGHIRIVITPH----SVMFCNTGAAQPLDAR-RIFERFYQGKKKE---GSTGLGLAIADTICKMQ 404
Cdd:smart00387 9 VLSNLLDNAIKYTPEGGRITVTLERDgdhvEITVEDNGPGIPPEDLeKIFEPFFRTDKRSrkiGGTGLGLSIVKKLVELH 88
|
90
....*....|....*....
gi 492447620 405 ALRLCYEYKSGEH-CFTLY 422
Cdd:smart00387 89 GGEISVESEPGGGtTFTIT 107
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
326-403 |
6.86e-10 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 56.22 E-value: 6.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 326 NETLAVVLLTNLLKNAFVHNMDGGHIRIVITPH---SVMFCNTGAAQPLDAR-RIFERFYQGKK-KEGSTGLGLAIADTI 400
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEGgelTLTVEDNGIGIPPEDLpRIFEPFSTADKrGGGGTGLGLSIVRKL 81
|
...
gi 492447620 401 CKM 403
Cdd:pfam02518 82 VEL 84
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
127-422 |
2.10e-29 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 116.93 E-value: 2.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 127 SIEKEDLKDAMAGWIIFLYIALLLTIIVINVWVFYRNMRPLYVLLHWLDKYRIGKVNEPLQNNTRVSEFRKLNEAAVRYA 206
Cdd:COG0642 21 ALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 207 ERSEQMFEQQKQFIGNASHEMQTPLAICRNRLEMLMEDenLSESQLEELMKTHQTLEHITKLNKSLLLLSKIENGQFT-D 285
Cdd:COG0642 101 LLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE--LDEEQREYLETILRSADRLLRLINDLLDLSRLEAGKLElE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 286 TVQVEVNKLLRQYLEDYKEVYQYREIITSIE-EEGVFYLTINETLAVVLLTNLLKNAFVHNMDGGHIRIVITPHSVMFC- 363
Cdd:COG0642 179 PEPVDLAELLEEVVELFRPLAEEKGIELELDlPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRREGDRVRi 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492447620 364 ---NTGAAQPLDAR-RIFERFYQGKK--KEGSTGLGLAIADTICKMQALRLCYEYKSGEH-CFTLY 422
Cdd:COG0642 259 sveDTGPGIPPEDLeRIFEPFFRTDPsrRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGtTFTVT 324
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
200-404 |
4.76e-27 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 108.07 E-value: 4.76e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 200 EAAVRYAERSEQMfeqQKQFIGNASHEMQTPLAICRNRLEMLMEDENLSESQLEELMKT-HQTLEHITKLNKSLLLLSKI 278
Cdd:COG2205 3 EEALEELEELERL---KSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIiRESAERLLRLIEDLLDLSRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 279 ENGQFTDTVQ-VEVNKLLRQYLEDYKEVYQYREI-ITSIEEEGVFYLTINETLAVVLLTNLLKNAFVHNMDGGHIRIVI- 355
Cdd:COG2205 80 ESGKLSLELEpVDLAELLEEAVEELRPLAEEKGIrLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISAr 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 492447620 356 -TPHSVMF--CNTGAAQPLDAR-RIFERFYQGK--KKEGSTGLGLAIADTICKMQ 404
Cdd:COG2205 160 rEGDGVRIsvSDNGPGIPEEELeRIFERFYRGDnsRGEGGTGLGLAIVKRIVEAH 214
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
137-400 |
5.62e-26 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 108.49 E-value: 5.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 137 MAGWIIFLYIALLLTIIVINVWVFYRNMRPLYVLLHWLDKYRIGKVNEPLQNNTRVSEFRKLNEAAVRYAERSEQMFEQQ 216
Cdd:COG5002 86 LALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMR 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 217 KQFIGNASHEMQTPLAICRNRLEMLMEDENLSESQLEELMKT-HQTLEHITKLNKSLLLLSKIENGQFT-DTVQVEVNKL 294
Cdd:COG5002 166 REFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLEIiLEEAERLSRLVNDLLDLSRLESGELKlEKEPVDLAEL 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 295 LRQYLEDYKEVYQYREI-ITSIEEEGVFYLTINETLAVVLLTNLLKNAFVHNMDGGHIRIVITPHS----VMFCNTG--- 366
Cdd:COG5002 246 LEEVVEELRPLAEEKGIeLELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDdqvrISVRDTGigi 325
|
250 260 270
....*....|....*....|....*....|....*...
gi 492447620 367 AAQPLDarRIFERFYQGKK----KEGSTGLGLAIADTI 400
Cdd:COG5002 326 PEEDLP--RIFERFYRVDKsrsrETGGTGLGLAIVKHI 361
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
121-421 |
4.64e-15 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 76.66 E-value: 4.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 121 LTVATPSIEKEDLKDAMAGWIIFLYIALLLTIIVINVWVFYRNMRPLYVLL--------HWLDkYRIGKVNEPlqnntrv 192
Cdd:TIGR01386 146 ITVALDINAHTHLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSavaarispESLD-QRLDPSRAP------- 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 193 SEFRKLNEAAVRYAERSEQMFEQQKQFIGNASHEMQTPL---------AICRNRleMLMEDENLSESQLEElmkthqtLE 263
Cdd:TIGR01386 218 AELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLtnllgqtqvALSQPR--TGEEYREVLESNLEE-------LE 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 264 HITKLNKSLLLLSKIENGQFT-DTVQVEVNKLLRQYLEDYKEVYQYREIitSIEEEGVFYLTINETLAVVLLTNLLKNAF 342
Cdd:TIGR01386 289 RLSRMVSDMLFLARADNGQLAlERVRLDLAAELAKVAEYFEPLAEERGV--RIRVEGEGLVRGDPQMFRRAISNLLSNAL 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 343 VHNMDGGHIRIVITPHSVMFC----NTGAAQPLDAR-RIFERFYQG----KKKEGSTGLGLAIADTICKMQALRLCYEYK 413
Cdd:TIGR01386 367 RHTPDGGTITVRIERRSDEVRvsvsNPGPGIPPEHLsRLFDRFYRVdparSNSGEGTGLGLAIVRSIMEAHGGRASAESP 446
|
....*...
gi 492447620 414 SGEHCFTL 421
Cdd:TIGR01386 447 DGKTRFIL 454
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
140-408 |
2.96e-14 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 74.30 E-value: 2.96e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 140 WIIFLYIALLLTIivinvWVFYRNMRPLYVLLHWLdKYRIGKVNEPLqNNTRV-SEFRKLNEAAVRYAERSEQMFEQQKQ 218
Cdd:PRK10337 167 WLVALPIMLIILM-----VLLGRELAPLKKLALAL-RMRDPDSETPL-NATGVpSEVRPLVEALNQLFARTHAMMVRERR 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 219 FIGNASHEMQTPLAICRNRLE---MLMEDENLSESQLEELmktHQTLEHITKLNKSLLLLSKIENG-QFTDTVQVEVNKL 294
Cdd:PRK10337 240 FTSDAAHELRSPLAALKVQTEvaqLSDDDPQARKKALLQL---HAGIDRATRLVDQLLTLSRLDSLdNLQDVAEIPLEDL 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 295 LRQYLED-YKEVYQYR-EIITSIEEEGVFyLTINETLAVVLLTNLLKNAFVHNMDGGHIRIVITPHSVMFCNTGAAQPLD 372
Cdd:PRK10337 317 LQSAVMDiYHTAQQAGiDVRLTLNAHPVI-RTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVRDNGPGVTPE 395
|
250 260 270
....*....|....*....|....*....|....*....
gi 492447620 373 A-RRIFERFYQ--GKKKEGStGLGLAIADTICKMQALRL 408
Cdd:PRK10337 396 AlARIGERFYRppGQEATGS-GLGLSIVRRIAKLHGMNV 433
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
144-421 |
6.54e-13 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 70.02 E-value: 6.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 144 LYIALLLTIIVInVWvfyrnMRPlyvllHWLDKYRIGKVNEPLQN---NTRV-----SEFRKLNEAAVRYAERSEQMFEQ 215
Cdd:PRK10604 143 ALIGLSLAFPVF-LW-----MRP-----HWQDMLKLEAAAQRLGDghlAERIhfdegSSLERLGVAFNQMADNINALIAS 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 216 QKQFIGNASHEMQTPLAICRNRLEMLmedENLSES----------QLEEL---MKTHQTLehitklnksllllskiengq 282
Cdd:PRK10604 212 KKQLIDGIAHELRTPLVRLRYRLEMS---DNLSAAesqalnrdigQLEALieeLLTYARL-------------------- 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 283 ftDTVQVEVN-------KLLRQYLEDYKEVYQYREIITSIEEEGVfYLTINETLAVVLLTNLLKNAFVHNmdGGHIRIVI 355
Cdd:PRK10604 269 --DRPQNELHlsepdlpAWLSTHLADIQAVTPEKTVRLDTPHQGD-YGALDMRLMERVLDNLLNNALRYA--HSRVRVSL 343
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492447620 356 TPHSVMFC----NTGAAQPLDAR-RIFERFYQ----GKKKEGSTGLGLAIADTIckMQALR---LCYEYKSGEHCFTL 421
Cdd:PRK10604 344 LLDGNQACliveDDGPGIPPEEReRVFEPFVRldpsRDRATGGCGLGLAIVHSI--ALAMGgsvNCDESELGGARFSF 419
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
333-422 |
6.78e-12 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 61.46 E-value: 6.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 333 LLTNLLKNAFVHNMDGGHIRIVI--TPHSVMFC--NTGAAQPLDAR-RIFERFYQGKK--KEGSTGLGLAIADTICKMQA 405
Cdd:cd00075 4 VLSNLLDNALKYSPPGGTIEISLrqEGDGVVLEveDNGPGIPEEDLeRIFERFYRGDKsrEGGGTGLGLAIVRRIVEAHG 83
|
90
....*....|....*...
gi 492447620 406 LRLCYEYKSGEH-CFTLY 422
Cdd:cd00075 84 GRITVESEPGGGtTFTVT 101
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
121-396 |
1.64e-11 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 65.64 E-value: 1.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 121 LTVATPS------IEKEDLKDAMAGWIIFLyIALLLTIIVInVWVFyrnmRPLYVLLHWLDKYRIG-KVNEPLQnntRVS 193
Cdd:PRK11100 164 LSVGKPNssmapfIKRSERRILWAGALLLG-IALLIGAGVV-WWLN----RSIRRLTRYADAVTEGkPVPLPKL---GSS 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 194 EFRKLNEAAvryaersEQMFEQ--QKQFIGN----ASHEMQTPLAICRNRLEMLmeDENLSESQLEELMKTHQT-LEHIT 266
Cdd:PRK11100 235 ELRELAQAL-------ESMRVKleGKAYVEQyvqtLTHELKSPLAAIRGAAELL--QEDPPPEDRARFTGNILTqSARLQ 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 267 KLNKSLLLLSKIENGQFTDTVQ-VEVNKLLRQYLEDYKEVYQYREIITSIEEEGV------FYLTinetLAvvlLTNLLK 339
Cdd:PRK11100 306 QLIDRLLELARLEQRQELEVLEpVALAALLEELVEAREAQAAAKGITLRLRPDDArvlgdpFLLR----QA---LGNLLD 378
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492447620 340 NA--FVHNmdGGHIRIVITPH------SVMfcNTGAAQPLDAR-RIFERFY------QGKKkegSTGLGLAI 396
Cdd:PRK11100 379 NAidFSPE--GGTITLSAEVDgeqvalSVE--DQGPGIPDYALpRIFERFYslprpaNGRK---STGLGLAF 443
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
183-396 |
7.55e-11 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 63.49 E-value: 7.55e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 183 NEPLQ---NNTRVSEFRklneaAVRYAERSEQM----FEQQKQ-------FIGNASHEMQTPLAICRNRLEMlMEDENLs 248
Cdd:PRK11006 162 SRPLTlvlNNGRHLEIR-----VMPYTEGQLLMvardVTQMHQlegarrnFFANVSHELRTPLTVLQGYLEM-MQDQPL- 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 249 ESQLEElmKTHQTLEHITK----LNKSLLLLSKIENGQFTD-TVQVEVNKLLRqYLEdykevyqyREIITSIEEEGVFYL 323
Cdd:PRK11006 235 EGALRE--KALHTMREQTQrmegLVKQLLTLSKIEAAPTIDlNEKVDVPMMLR-VLE--------REAQTLSQGKHTITF 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 324 TINETLAVV--------LLTNLLKNAFVHNMDGGHIRI--VITPHSVMF--CNTG---AAQPLDarRIFERFYQGKK--- 385
Cdd:PRK11006 304 EVDNSLKVFgnedqlrsAISNLVYNAVNHTPEGTHITVrwQRVPQGAEFsvEDNGpgiAPEHIP--RLTERFYRVDKars 381
|
250
....*....|..
gi 492447620 386 -KEGSTGLGLAI 396
Cdd:PRK11006 382 rQTGGSGLGLAI 393
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
333-422 |
3.84e-10 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 56.89 E-value: 3.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 333 LLTNLLKNAFVHNMDGGHIRIVITPH----SVMFCNTGAAQPLDAR-RIFERFYQGKKKE---GSTGLGLAIADTICKMQ 404
Cdd:smart00387 9 VLSNLLDNAIKYTPEGGRITVTLERDgdhvEITVEDNGPGIPPEDLeKIFEPFFRTDKRSrkiGGTGLGLSIVKKLVELH 88
|
90
....*....|....*....
gi 492447620 405 ALRLCYEYKSGEH-CFTLY 422
Cdd:smart00387 89 GGEISVESEPGGGtTFTIT 107
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
326-403 |
6.86e-10 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 56.22 E-value: 6.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 326 NETLAVVLLTNLLKNAFVHNMDGGHIRIVITPH---SVMFCNTGAAQPLDAR-RIFERFYQGKK-KEGSTGLGLAIADTI 400
Cdd:pfam02518 2 DELRLRQVLSNLLDNALKHAAKAGEITVTLSEGgelTLTVEDNGIGIPPEDLpRIFEPFSTADKrGGGGTGLGLSIVRKL 81
|
...
gi 492447620 401 CKM 403
Cdd:pfam02518 82 VEL 84
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
104-422 |
1.55e-09 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 59.04 E-value: 1.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 104 ARILTTIFKDDGEKFFELTVATPSIEKEDLKDAMAGWIIFLYIALLLTIIVINVWVFYRNMRPLYVLLHWLDKYRIGKVN 183
Cdd:COG4191 21 ALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 184 EPLQNNTRVSEFRKLNEAAVRYAERS----EQMFEQQK-----QFIGNASHEMQTPLAICRNRLEMLME--DENLSESQL 252
Cdd:COG4191 101 LDAEENAELEELERDITELERAEEELrelqEQLVQSEKlaalgELAAGIAHEINNPLAAILGNAELLRRrlEDEPDPEEL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 253 EELM-KTHQTLEHITKLnksllllskIEN------GQFTDTVQVEVNKLLRQYLEDYKEVYQYREIITSIE-EEGVFYLT 324
Cdd:COG4191 181 REALeRILEGAERAAEI---------VRSlrafsrRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDlPPDLPPVL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 325 INET-LAVVLLtNLLKNAF--VHNMDGGHIRIVITPHS----VMFCNTGAAQPLDAR-RIFERFYQGKKKEGSTGLGLAI 396
Cdd:COG4191 252 GDPGqLEQVLL-NLLINAIdaMEEGEGGRITISTRREGdyvvISVRDNGPGIPPEVLeRIFEPFFTTKPVGKGTGLGLSI 330
|
330 340
....*....|....*....|....*....
gi 492447620 397 ADTIckMQAL--RLCYEYKSGEH-CFTLY 422
Cdd:COG4191 331 SYGI--VEKHggRIEVESEPGGGtTFTIT 357
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
207-400 |
4.60e-09 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 58.11 E-value: 4.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 207 ERSEQMfeqQKQFIGNASHEMQTPLAICRNRLEMLMED------ENLSESQLE--ELMKTHQTLEHITKLnksllllski 278
Cdd:PRK10549 234 EKNEQM---RRDFMADISHELRTPLAVLRGELEAIQDGvrkftpESVASLQAEvgTLTKLVDDLHQLSLS---------- 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 279 ENGQFT-DTVQVEVNKLLRQYLEDYKEVYQYREII--TSIEEEGVFY-----LTinetlavVLLTNLLKNAFVHNMDGG- 349
Cdd:PRK10549 301 DEGALAyRKTPVDLVPLLEVAGGAFRERFASRGLTlqLSLPDSATVFgdpdrLM-------QLFNNLLENSLRYTDSGGs 373
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 492447620 350 -HIRIVITPHSVMFCNTGAAQPLDAR---RIFERFYQGK----KKEGSTGLGLAIADTI 400
Cdd:PRK10549 374 lHISAEQRDKTLRLTFADSAPGVSDEqlqKLFERFYRTEgsrnRASGGSGLGLAICLNI 432
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
190-421 |
1.78e-08 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 56.57 E-value: 1.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 190 TRVSE-FRKLNEAAvryaERSEQMFEQQKQFIGNASHEMQTPLAICRNRLEMLmEDENLSESQLEELMKTHQTLEHITKL 268
Cdd:PRK15347 375 NKVAErTQALAEAK----QRAEQANKRKSEHLTTISHEIRTPLNGVLGALELL-QNTPLTAEQMDLADTARQCTLSLLAI 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 269 NKSLLLLSKIENGQFTdtVQVEVNKLLrQYLEDYKEVYQYREIITSIEEEGVFYLTINETLAV------VLLTNLLKNAf 342
Cdd:PRK15347 450 INNLLDFSRIESGQMT--LSLEETALL-PLLDQAMLTIQGPAQSKSLTLRTFVGAHVPLYLHLdslrlrQILVNLLGNA- 525
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 343 VHNMDGGHIRIVITPHSVMFC----NTGAA-QPLDARRIFERFYQGKKKEGSTGLGLAIADTICKMQALRLCYEYKSGE- 416
Cdd:PRK15347 526 VKFTETGGIRLRVKRHEQQLCftveDTGCGiDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVg 605
|
....*
gi 492447620 417 HCFTL 421
Cdd:PRK15347 606 SCFSL 610
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-419 |
2.38e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 51.62 E-value: 2.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 334 LTNLLKNAFVHNMDGGHIRIVITPHS----VMFCNTGAAQ-PLDARRIFERFYQG---KKKEGStGLGLAIADTICKMQA 405
Cdd:cd16923 5 FSNLLSNAIKYSPENTRIYITSFLTDdvvnIMFKNPSSHPlDFKLEKLFERFYRGdnsRNTEGA-GLGLSIAKAIIELHG 83
|
90
....*....|....
gi 492447620 406 LRLCYEYKSGEHCF 419
Cdd:cd16923 84 GSASAEYDDNHDLF 97
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
333-396 |
1.81e-07 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 49.41 E-value: 1.81e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492447620 333 LLTNLLKNAFVHNMDGGHIRIVITPHSVMFC-----NTGAAQPLDAR-RIFERFYQG----KKKEGSTGLGLAI 396
Cdd:cd16925 8 VVLNLLSNAFKFTPDGGRIRCILEKFRLNRFlltvsDSGPGIPPNLReEIFERFRQGdgssTRAHGGTGLGLSI 81
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
289-401 |
1.38e-06 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 50.35 E-value: 1.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 289 VEVNKLLRQYLEDYKEVYQYREIITSIE-EEGVFYLTINETLAVVLLTNLLKNAFVHNMDGGHIRIVITPHS----VMFC 363
Cdd:COG5000 276 VDLNELLREVLALYEPALKEKDIRLELDlDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDgrvrIEVS 355
|
90 100 110
....*....|....*....|....*....|....*....
gi 492447620 364 NTGAAQPLDAR-RIFERFYQGKKKegSTGLGLAIADTIC 401
Cdd:COG5000 356 DNGPGIPEEVLeRIFEPFFTTKPK--GTGLGLAIVKKIV 392
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
207-400 |
2.13e-06 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 49.77 E-value: 2.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 207 ERSEQMFEQQKQFIGNASHEMQTPLAICRNRLEMLMEdENLSESQLEELMktHQTLEhitklnksllllskiENGQFTDT 286
Cdd:PRK09835 253 ERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALS-QSRSQKELEDVL--YSNLE---------------ELTRMAKM 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 287 V-------QVEVNKLL--RQYLEDYKEVYQYREIITSIEEEGVFYLTINETLAVV---------LLTNLLKNAFVHNMDG 348
Cdd:PRK09835 315 VsdmlflaQADNNQLIpeKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVagdplmlrrAISNLLSNALRYTPAG 394
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492447620 349 GHI--RIVITPHSVMFCNTGAAQPLDAR---RIFERFY-----QGKKKEGStGLGLAIADTI 400
Cdd:PRK09835 395 EAItvRCQEVDHQVQLVVENPGTPIAPEhlpRLFDRFYrvdpsRQRKGEGS-GIGLAIVKSI 455
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
214-266 |
3.63e-06 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 44.13 E-value: 3.63e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 492447620 214 EQQKQFIGNASHEMQTPLAICRNRLEMLMEDENLSESQLEELMKTHQTLEHIT 266
Cdd:cd00082 2 QAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLL 54
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
333-400 |
2.80e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 42.84 E-value: 2.80e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492447620 333 LLTNLLKNAFVHNMDGG--HIRIVITPHSV--MFCNTGAAQPLDA-RRIFERFYQG----KKKEGSTGLGLAIADTI 400
Cdd:cd16946 8 LFVNLLENSLRYTDTGGklRIRAAQTPQEVrlDVEDSAPGVSDDQlARLFERFYRVessrNRASGGSGLGLAICHNI 84
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
127-401 |
3.33e-05 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 45.73 E-value: 3.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 127 SIEKEdLKDAMAGWIIFLYIALLLTIiVINVWVFYRNMRPLYVLLHWLDKyRIGKVNEPLQNNTRVSEF----RKLNEAA 202
Cdd:PRK10755 51 HVMKE-IREAVASLLVPSLVMVSLTL-LICFQAVRWITRPLAELQKELEA-RTADNLTPIAIHSSTLEIeavtSALNQLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 203 VRYAErseqMFEQQKQFIGNASHEMQTPLAICRNRLEmLMEDENLSESQ-----LEELMKTHQTLEHITKLnksllllsk 277
Cdd:PRK10755 128 SRLTS----TLDQERLFTADVAHELRTPLAGIRLHLE-LLEKQHHIDVApliarLDQMMHTVEQLLQLARA--------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 278 ienGQ-FT----DTVQV--EVNKLLRQYLEDYKEVYQYREIITSIEEEgvFYLTINETLAVVLLTNLLKNAFVHNMDGGH 350
Cdd:PRK10755 194 ---GQsFSsghyQTVKLleDVILPSQDELSEMLEQRQQTLLLPESAAD--ITVQGDATLLRLLLRNLVENAHRYSPEGST 268
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 492447620 351 IRIVITPH------SVMFCNTG--AAQPLDARRIFERFYQgkkKEGSTGLGLAIADTIC 401
Cdd:PRK10755 269 ITIKLSQEdggavlAVEDEGPGidESKCGELSKAFVRMDS---RYGGIGLGLSIVSRIT 324
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
8-397 |
3.33e-05 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 45.93 E-value: 3.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 8 IIRISLVLSVLLTGWAILFYFAVMDEVNDEVDDSLEDYSEIIIIRALAGEELPSKNTASNNQYFLREVTKEYAGSCDDII 87
Cdd:COG4251 78 LALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLL 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 88 YKDSMVYIPEKDETEPARILTTIFKDDGEKFFELTVATPSIEKEDLKDAMAGWIIFLYIALLLTIIVINVWVFYRNMRPL 167
Cdd:COG4251 158 LLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVL 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 168 YVLLHWLDKYRIgkvnEPLQNNTRVSEFRKLNEAAVRYAERSEQMFEQQKQFIGNASHEMQTPL-AIcRNRLEMLMED-- 244
Cdd:COG4251 238 LLLLILLLLLLI----LVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHDLREPLrKI-SGFSQLLEEDyg 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 245 ENLSESQLEELMKTHQTLEHITKLnksllllskIE--------NGQFTDTVQVEVNKLLRQYLEDYKEVYQYREIITSIE 316
Cdd:COG4251 313 DKLDEEGREYLERIRDAAERMQAL---------IDdllaysrvGRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVG 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 317 EEGVfyLTINETLAVVLLTNLLKNAFVHNMDGGHIRIVIT----PHSVMFC---N-TGAAqPLDARRIFERFYQ--GKKK 386
Cdd:COG4251 384 PLPT--VRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGaereGGEWVFSvrdNgIGID-PEYAEKIFEIFQRlhSRDE 460
|
410
....*....|.
gi 492447620 387 EGSTGLGLAIA 397
Cdd:COG4251 461 YEGTGIGLAIV 471
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
328-408 |
3.49e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 42.78 E-value: 3.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 328 TLAVVLLTNLLKNAFVHNMDGGHIRIVIT--PHSVM-FCNTGAAQPLDAR-RIFERFYQ-GKKKEGSTGLGLAIADTICK 402
Cdd:cd16940 12 LLLFLLLRNLVDNAVRYSPQGSRVEIKLSadDGAVIrVEDNGPGIDEEELeALFERFYRsDGQNYGGSGLGLSIVKRIVE 91
|
....*.
gi 492447620 403 MQALRL 408
Cdd:cd16940 92 LHGGQI 97
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
215-265 |
3.70e-05 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 41.43 E-value: 3.70e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 492447620 215 QQKQFIGNASHEMQTPLAICRNRLEMLMEDENLSESQ--LEELMKTHQTLEHI 265
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQReyLETILRSAERLLRL 53
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-402 |
4.55e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 42.41 E-value: 4.55e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492447620 334 LTNLLKNAfVHNMDG-GHIRIVITPHS----VMFCNTGAA-QPLDARRIFERFYQGKKKEGSTGLGLAIADTICK 402
Cdd:cd16943 8 LLNLLVNA-AQAMEGrGRITIRTWAHVdqvlIEVEDTGSGiDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQ 81
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
334-403 |
4.80e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 42.48 E-value: 4.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 334 LTNLLKNA--FVHNmdgGHIRIVI-------TPHSVMFC--NTGAAQPLDAR-RIFERFYQGK----KKEGSTGLGLAIA 397
Cdd:cd16922 5 LLNLLGNAikFTEE---GEVTLRVsleeeeeDGVQLRFSveDTGIGIPEEQQaRLFEPFSQADssttRKYGGTGLGLAIS 81
|
....*.
gi 492447620 398 DTICKM 403
Cdd:cd16922 82 KKLVEL 87
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
215-265 |
1.04e-04 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 40.24 E-value: 1.04e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 492447620 215 QQKQFIGNASHEMQTPLAICRNRLEMLmEDENLSESQLEELMKTHQTLEHI 265
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELL-LDTELSEEQREYLETILREAERL 50
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
216-415 |
3.81e-04 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 42.80 E-value: 3.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 216 QKQFIGNASHEMQTPLAICRNRLEMLMEDENLSESQLEELMKTHQTLEHITKLNKSLLLLSKIENGQFTDTVQ-VEVNKL 294
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQwVDIPTL 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 295 LRQYLEDYKEVYQYREIITSIEEE--GVFYLTINETLAVVLLTNLLKNAFVHNMDGG--------HI--RIVITPHSVMF 362
Cdd:PRK09959 792 VQNTCHSFGAIAASKSIALSCSSTfpDHYLVKIDPQAFKQVLSNLLSNALKFTTEGAvkittslgHIddNHAVIKMTIMD 871
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 492447620 363 CNTGAAQPlDARRIFERFYQ---GKKKEGStGLGLAIADTICKMQALRLCYEYKSG 415
Cdd:PRK09959 872 SGSGLSQE-EQQQLFKRYSQtsaGRQQTGS-GLGLMICKELIKNMQGDLSLESHPG 925
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-403 |
9.58e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 38.60 E-value: 9.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 334 LTNLLKNAFVHNMDGGHIRIVITPHS----VMFCNTGAAQPLDAR-RIFERFY------QGKKkegSTGLGLAIADTICK 402
Cdd:cd16945 9 INNLLDNAIDFSPEGGLIALQLEADTegieLLVFDEGSGIPDYALnRVFERFYslprphSGQK---STGLGLAFVQEVAQ 85
|
.
gi 492447620 403 M 403
Cdd:cd16945 86 L 86
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
334-396 |
1.20e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 38.34 E-value: 1.20e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492447620 334 LTNLLKNAFVHNMDGGHIRI--VITPHSVMFC--NTG-AAQPLDARRIFERFYQ----GKKKEGSTGLGLAI 396
Cdd:cd16952 5 FSNLVSNAVKYTPPSDTITVrwSQEESGARLSveDTGpGIPPEHIPRLTERFYRvdieRCRNTGGTGLGLAI 76
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
191-402 |
1.83e-03 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 40.22 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 191 RVSEFRKLNEaavrYAERSEQMfEQQKQFIGNA---SHEMqtplaicRNRL---EMLMEDENLSESQ--LEELMKTHQTL 262
Cdd:COG3290 166 AVATFRDRTE----LERLEEEL-EGVKELAEALraqRHDF-------RNHLhtiSGLLQLGEYDEALeyIDEISEELQEL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 263 ehitklnkSLLLLSKIENgqftdtvqVEVNKLLRQYLEDYKEvyqyREIITSIEEEGVF-YLTINETLAVVLLTNLLKNA 341
Cdd:COG3290 234 --------IDSLLSRIGN--------PVLAALLLGKAARARE----RGIDLTIDIDSDLpDLPLSDTDLVTILGNLLDNA 293
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492447620 342 FVH---------------NMDGGHIRIVITphsvmfcNTGA-AQPLDARRIFERFYQGKKKEGStGLGLAIADTICK 402
Cdd:COG3290 294 IEAveklpeeerrvelsiRDDGDELVIEVE-------DSGPgIPEELLEKIFERGFSTKLGEGR-GLGLALVKQIVE 362
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
332-396 |
2.73e-03 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 39.55 E-value: 2.73e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492447620 332 VLLtNLLKNAFVHNMDGGHIRIVI---TPHSVMF--CNTGAAQPLDAR-RIFE---RFYQGKKKEGsTGLGLAI 396
Cdd:PRK09303 276 VLL-NLLDNAIKYTPEGGTITLSMlhrTTQKVQVsiCDTGPGIPEEEQeRIFEdrvRLPRDEGTEG-YGIGLSV 347
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
332-402 |
5.14e-03 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 38.67 E-value: 5.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492447620 332 VLLtNLLKNAFVHNMDGGHIRIVITP-HSVMFCNTGAAQPL--------------DARRIFERFYQGKkkEGSTGLGLAI 396
Cdd:COG3852 248 VLL-NLVRNAAEAMPEGGTITIRTRVeRQVTLGGLRPRLYVrievidngpgipeeILDRIFEPFFTTK--EKGTGLGLAI 324
|
....*.
gi 492447620 397 ADTICK 402
Cdd:COG3852 325 VQKIVE 330
|
|
| Mob_synth_C |
pfam06463 |
Molybdenum Cofactor Synthesis C; This region contains two iron-sulphur (3Fe-4S) binding sites. ... |
303-365 |
7.93e-03 |
|
Molybdenum Cofactor Synthesis C; This region contains two iron-sulphur (3Fe-4S) binding sites. Mutations in this region of Swiss:O14940 cause MOCOD (Molybdenum Co-Factor Deficiency) type A.
Pssm-ID: 428955 [Multi-domain] Cd Length: 127 Bit Score: 36.43 E-value: 7.93e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492447620 303 KEVYQYREIITSIEEEGVFYLTINETLAvvlltnllkNAFVHNMDGGHIRI-VITPHSVMFCNT 365
Cdd:pfam06463 20 KKFVSLDEILERIEARFPLLPARKRTGG---------PAKRYRIPGGGGRIgFIAPVSNPFCAS 74
|
|
| |
