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Conserved domains on  [gi|492476667|ref|WP_005857723|]
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MULTISPECIES: GNAT family N-acetyltransferase [Parabacteroides]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 1006192)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

EC:  2.3.1.-
Gene Ontology:  GO:0008080
PubMed:  10940244|9175471
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eis super family cl34773
Predicted acetyltransferase [General function prediction only];
5-232 4.41e-27

Predicted acetyltransferase [General function prediction only];


The actual alignment was detected with superfamily member COG4552:

Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 109.22  E-value: 4.41e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667   5 QQIVNLWRTCFGD--SEAFISLYFdRVYKDENAMTIEKDGKIVSALQIVPHTMTYLGTEISVGYISGACTTPEERGQGLM 82
Cdd:COG4552   12 DAFARLLAYAFGPepDDEELEAYR-PLLEPGRVLGVFDDGELVGTLALYPFTLNVGGARVPMAGITGVAVAPEHRRRGVA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667  83 RQLLQETFEEMERREIAISALIPADPwlfDYYREQGYTEAFD---YSVETYIRPNTPVQLPKITVIQPEvpTTDELFAYF 159
Cdd:COG4552   91 RALLREALAELRERGQPLSALYPFEP---GFYRRFGYELAGDrrrYTIPPESLPLRPDAPGRVRRVDPD--DAELLAALY 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492476667 160 NRKLRERPSCILHSQDDFITILRDLQLDNGGMYTALDENEKVVGMAFalpLEAGTAPSDKKLFIKELLYDSEE 232
Cdd:COG4552  166 ERFARRRPGALDRDEAWWERVLRDLGGEPLRAAVHYDEDGEPDGYVL---YRVKDGGDGGTLEVRELVALTPE 235
 
Name Accession Description Interval E-value
Eis COG4552
Predicted acetyltransferase [General function prediction only];
5-232 4.41e-27

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 109.22  E-value: 4.41e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667   5 QQIVNLWRTCFGD--SEAFISLYFdRVYKDENAMTIEKDGKIVSALQIVPHTMTYLGTEISVGYISGACTTPEERGQGLM 82
Cdd:COG4552   12 DAFARLLAYAFGPepDDEELEAYR-PLLEPGRVLGVFDDGELVGTLALYPFTLNVGGARVPMAGITGVAVAPEHRRRGVA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667  83 RQLLQETFEEMERREIAISALIPADPwlfDYYREQGYTEAFD---YSVETYIRPNTPVQLPKITVIQPEvpTTDELFAYF 159
Cdd:COG4552   91 RALLREALAELRERGQPLSALYPFEP---GFYRRFGYELAGDrrrYTIPPESLPLRPDAPGRVRRVDPD--DAELLAALY 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492476667 160 NRKLRERPSCILHSQDDFITILRDLQLDNGGMYTALDENEKVVGMAFalpLEAGTAPSDKKLFIKELLYDSEE 232
Cdd:COG4552  166 ERFARRRPGALDRDEAWWERVLRDLGGEPLRAAVHYDEDGEPDGYVL---YRVKDGGDGGTLEVRELVALTPE 235
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 2-119 6.77e-26

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 99.57  E-value: 6.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667    2 DKKQQIVNLWRTCFGDSE-AFISLYFDRVYKDENAMTIEKDGKIVSALQIVPHTMTYLGTEISVGYISGACTTPEERGQG 80
Cdd:pfam13527   7 DEFDEVLRLLEYAFQDEDsPELREYFRPLLEEGRVLGAFDDGELVSTLALYPFELNVPGKTLPAAGITGVATYPEYRGRG 86

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 492476667   81 LMRQLLQETFEEMERREIAISALIPADPwlfDYYREQGY 119
Cdd:pfam13527  87 VMSRLLRRSLEEMRERGVPLSFLYPSSY---PIYRRFGY 122
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 38-98 8.26e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 8.26e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492476667  38 IEKDGKIVSALQIVPHtmtylGTEISVGYISGACTTPEERGQGLMRQLLQETFEEMERREI 98
Cdd:cd04301    4 AEDDGEIVGFASLSPD-----GSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGA 59
 
Name Accession Description Interval E-value
Eis COG4552
Predicted acetyltransferase [General function prediction only];
5-232 4.41e-27

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 109.22  E-value: 4.41e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667   5 QQIVNLWRTCFGD--SEAFISLYFdRVYKDENAMTIEKDGKIVSALQIVPHTMTYLGTEISVGYISGACTTPEERGQGLM 82
Cdd:COG4552   12 DAFARLLAYAFGPepDDEELEAYR-PLLEPGRVLGVFDDGELVGTLALYPFTLNVGGARVPMAGITGVAVAPEHRRRGVA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667  83 RQLLQETFEEMERREIAISALIPADPwlfDYYREQGYTEAFD---YSVETYIRPNTPVQLPKITVIQPEvpTTDELFAYF 159
Cdd:COG4552   91 RALLREALAELRERGQPLSALYPFEP---GFYRRFGYELAGDrrrYTIPPESLPLRPDAPGRVRRVDPD--DAELLAALY 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492476667 160 NRKLRERPSCILHSQDDFITILRDLQLDNGGMYTALDENEKVVGMAFalpLEAGTAPSDKKLFIKELLYDSEE 232
Cdd:COG4552  166 ERFARRRPGALDRDEAWWERVLRDLGGEPLRAAVHYDEDGEPDGYVL---YRVKDGGDGGTLEVRELVALTPE 235
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 2-119 6.77e-26

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 99.57  E-value: 6.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667    2 DKKQQIVNLWRTCFGDSE-AFISLYFDRVYKDENAMTIEKDGKIVSALQIVPHTMTYLGTEISVGYISGACTTPEERGQG 80
Cdd:pfam13527   7 DEFDEVLRLLEYAFQDEDsPELREYFRPLLEEGRVLGAFDDGELVSTLALYPFELNVPGKTLPAAGITGVATYPEYRGRG 86

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 492476667   81 LMRQLLQETFEEMERREIAISALIPADPwlfDYYREQGY 119
Cdd:pfam13527  87 VMSRLLRRSLEEMRERGVPLSFLYPSSY---PIYRRFGY 122
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
6-130 8.90e-11

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 58.94  E-value: 8.90e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667   6 QIVNLWRTCFGDS-EAFISLYFDRVYKDENAMTIEKDGKIVSALQIVPHTMTYlgtEISVGYISGACTTPEERGQGLMRQ 84
Cdd:COG3153   11 AIAALLRAAFGPGrEAELVDRLREDPAAGLSLVAEDDGEIVGHVALSPVDIDG---EGPALLLGPLAVDPEYRGQGIGRA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 492476667  85 LLQETFEEMERREIAISALIpADPWLFDYYREQGYTEAFDYSVETY 130
Cdd:COG3153   88 LMRAALEAARERGARAVVLL-GDPSLLPFYERFGFRPAGELGLTLG 132
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 38-121 1.34e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 42.83  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667   38 IEKDGKIVSALQIVPHTMTYLGTEISVgyisgaCTTPEERGQGLMRQLLQETFEEMERREIAISALIPADPWLfDYYREQ 117
Cdd:pfam13508   8 AEDDGKIVGFAALLPLDDEGALAELRL------AVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAA-AFYEKL 80


                  ....
gi 492476667  118 GYTE 121
Cdd:pfam13508  81 GFEE 84
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
22-121 3.52e-05

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 42.86  E-value: 3.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667  22 ISLYFDRVYKDENAMTI--EKDGKIVSALQIVPhtmtylgTEISVGYISGACTTPEERGQGLMRQLLQETFEEMERR--- 96
Cdd:COG2153   21 VPPYLELDGKDEDARHLlaYDDGELVATARLLP-------PGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERgar 93

                         90       100
                 ....*....|....*....|....*
gi 492476667  97 EIAISALIPADPWlfdyYREQGYTE 121
Cdd:COG2153   94 RIVLSAQAHAVGF----YEKLGFVP 114
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 5-119 4.09e-05

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 42.12  E-value: 4.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492476667    5 QQIVNLWRTCFGDSEAFISLYFDRVYKDENAMT---IEKDGKIVSALQIVPhtmtyLGTEISVGYISGACTTPEERGQGL 81
Cdd:pfam00583   2 EALYELLSEEFPEPWPDEPLDLLEDWDEDASEGffvAEEDGELVGFASLSI-----IDDEPPVGEIEGLAVAPEYRGKGI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 492476667   82 MRQLLQETFEEMERREIAISALI--PADPWLFDYYREQGY 119
Cdd:pfam00583  77 GTALLQALLEWARERGCERIFLEvaADNLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 38-98 8.26e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 39.95  E-value: 8.26e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492476667  38 IEKDGKIVSALQIVPHtmtylGTEISVGYISGACTTPEERGQGLMRQLLQETFEEMERREI 98
Cdd:cd04301    4 AEDDGEIVGFASLSPD-----GSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGA 59
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
63-127 2.88e-03

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 36.43  E-value: 2.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492476667  63 SVGYISGACTTPEERGQGLMRQLLQETFEEMERREIAISALI--PADPWLFDYYREQGYTEAFDYSV 127
Cdd:COG3393   14 GVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYvdADNPAARRLYERLGFRPVGEYAT 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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