MULTISPECIES: hypothetical protein [Parabacteroides]
Protein Classification
prenyltransferase/squalene oxidase repeat-containing protein( domain architecture ID 693)
prenyltransferase/squalene oxidase repeat-containing protein similar to Streptomyces anulatus copalyl diphosphate synthase and Aspergillus fumigatus squalene hopane cyclase afumA
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| CAL1 super family | cl34874 | Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
6-290 | 2.93e-17 | |||||
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]; The actual alignment was detected with superfamily member COG5029: Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 79.36 E-value: 2.93e-17
|
|||||||||
| Name | Accession | Description | Interval | E-value | |||||
| CAL1 | COG5029 | Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
6-290 | 2.93e-17 | |||||
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]; Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 79.36 E-value: 2.93e-17
|
|||||||||
| ISOPREN_C2_like | cd00688 | This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
166-290 | 4.45e-05 | |||||
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 44.08 E-value: 4.45e-05
|
|||||||||
| Name | Accession | Description | Interval | E-value | |||||
| CAL1 | COG5029 | Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, ... |
6-290 | 2.93e-17 | |||||
Prenyltransferase, beta subunit [Posttranslational modification, protein turnover, chaperones, Lipid transport and metabolism]; Pssm-ID: 444045 [Multi-domain] Cd Length: 259 Bit Score: 79.36 E-value: 2.93e-17
|
|||||||||
| AF1543 | COG1689 | Class II terpene cyclase family protein AF1543 [General function prediction only]; |
141-290 | 1.44e-05 | |||||
Class II terpene cyclase family protein AF1543 [General function prediction only]; Pssm-ID: 441295 [Multi-domain] Cd Length: 272 Bit Score: 45.49 E-value: 1.44e-05
|
|||||||||
| ISOPREN_C2_like | cd00688 | This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
166-290 | 4.45e-05 | |||||
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 44.08 E-value: 4.45e-05
|
|||||||||
| ISOPREN_C2_like | cd00688 | This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
144-287 | 1.55e-03 | |||||
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 39.46 E-value: 1.55e-03
|
|||||||||
| FTase | cd02893 | Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase ... |
157-221 | 4.43e-03 | |||||
Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. These proteins are heterodimers of alpha and beta subunits. Both subunits are required for catalytic activity. Prenyltransferases employ a Zn2+ ion to alkylate a thiol group catalyzing the formation of thioether linkages between cysteine residues at or near the C-terminus of protein acceptors and the C1 atom of isoprenoid lipids. Ftase attaches a 15-carbon farnesyl group to the cysteine within the C-terminal CaaX motif of substrate proteins when X is Ala, Met, Ser, Cys or Gln. Protein farnesylation has been shown to play critical roles in a variety of cellular processes including Ras/mitogen activated protein kinase signaling pathways in mammals and, abscisic acid signal transduction in Arabidopsis. Pssm-ID: 239223 [Multi-domain] Cd Length: 299 Bit Score: 37.99 E-value: 4.43e-03
|
|||||||||
| Blast search parameters | ||||
|
