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Conserved domains on  [gi|492597791|ref|WP_005899352|]
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MULTISPECIES: F0F1 ATP synthase subunit A [Fusobacterium]

Protein Classification

F0F1 ATP synthase subunit A( domain architecture ID 10001246)

F0F1 ATP synthase subunit A is part of the membrane proton channel of the F-type ATPase that produces ATP from ADP in the presence of a proton gradient across the membrane; it plays a direct role in the translocation of protons across the membrane

Gene Ontology:  GO:0045263|GO:0046933|GO:0005886|GO:0015986
PubMed:  28001127|11533110|12370007

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 31-244 1.12e-50

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


:

Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 164.48  E-value: 1.12e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  31 TVVTTWFVLFVFYLFFKLGTRNLQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIFLSNIITFFPIpw 110
Cdd:COG0356    2 TVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIGKKGRKFAPLLLTLFLFILVSNLLGLIPG-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 111 fsikngvfviypaFRAPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKG-FADPT----PVMLPLNVVGEFAKPLNIS 185
Cdd:COG0356   80 -------------LFPPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHlFFPPFpwlaPLMLPIEIISELARPLSLS 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492597791 186 MRLFGNMFAGMVIMGLIYMAVPYFVPAAL-------HLYFDLFAGLVQSFVFVTLSMVYVQGSIGD 244
Cdd:COG0356  147 LRLFGNMFAGHIILLLLAGLAPFLLLGVLslllpvaWTAFELLVGFLQAYIFTMLTAVYISLAVEE 212
 
Name Accession Description Interval E-value
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 31-244 1.12e-50

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 164.48  E-value: 1.12e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  31 TVVTTWFVLFVFYLFFKLGTRNLQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIFLSNIITFFPIpw 110
Cdd:COG0356    2 TVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIGKKGRKFAPLLLTLFLFILVSNLLGLIPG-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 111 fsikngvfviypaFRAPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKG-FADPT----PVMLPLNVVGEFAKPLNIS 185
Cdd:COG0356   80 -------------LFPPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHlFFPPFpwlaPLMLPIEIISELARPLSLS 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492597791 186 MRLFGNMFAGMVIMGLIYMAVPYFVPAAL-------HLYFDLFAGLVQSFVFVTLSMVYVQGSIGD 244
Cdd:COG0356  147 LRLFGNMFAGHIILLLLAGLAPFLLLGVLslllpvaWTAFELLVGFLQAYIFTMLTAVYISLAVEE 212
PRK05815 PRK05815
F0F1 ATP synthase subunit A; Validated
 16-246 1.33e-49

F0F1 ATP synthase subunit A; Validated


Pssm-ID: 235617  Cd Length: 227  Bit Score: 162.27  E-value: 1.33e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  16 GPDIIFSIFGIPISSTVVTTWFVLFVFYLFFKLGTRNLQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFL 95
Cdd:PRK05815   2 EHHLIIGFGGFNFDSLLLSVLLGVLILLLFALVATRKLSGVPGGLQNFVEMIVEFVRGQVKDNIGGKGKKFAPLAFTLFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  96 FIFLSNIITFFPIPWFSikngvfviypafraPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKGF-ADPTPVMLPLNV 174
Cdd:PRK05815  82 FILLMNLLGLIPYLLFP--------------PTADINVTLALALIVFVLVIYYGIKKKGLGGYLKEFyLQPHPLLLPIEI 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 175 VGEFAKPLNISMRLFGNMFAGMVIMGLIYMAVPY--------FVPAALHLYFDLFAGLVQSFVFVTLSMVYVQGSIGDAE 246
Cdd:PRK05815 148 ISEFSRPISLSLRLFGNMLAGELILALIALLGGAglllalapLILPVAWTIFEIFVGTLQAYIFMMLTIVYISMAVEEEH 227
ATP-synt_A pfam00119
ATP synthase A chain;
32-239 1.10e-39

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 136.47  E-value: 1.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791   32 VVTTWFVLFVFYLFFKLGTRN-LQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYT-FFASLFLFIFLSNIItffpip 109
Cdd:pfam00119   1 LLMSLIVALILLLFLLLATRKtKKLVPGRLQNFVEMLVEFVDNIVKDNIGKKKGRKFFpLLLTLFFFILVSNLL------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  110 wfsiknGVFVIYPAFRAPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKGFADP------TPVMLPLNVVGEFAKPLN 183
Cdd:pfam00119  75 ------GLIPKSPGGFTVTADINVTLALALIVFLLVHYYGIKKHGLGGYFKKLFVPpvplplVPLLLPIEIISEFARPVS 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492597791  184 ISMRLFGNMFAGMVIMGLIYMAVPYF------------VPAALHLYFDLFAGLVQSFVFVTLSMVYVQ 239
Cdd:pfam00119 149 LSLRLFGNMLAGHLLLLLLAGLIFALlsagfllgvippLLGVAWTLFELLVAFIQAYVFTMLTAVYIS 216
altF1_A TIGR03306
alternate F1F0 ATPase, F0 subunit A; A small number of taxonomically diverse prokaryotic ...
 26-238 2.21e-29

alternate F1F0 ATPase, F0 subunit A; A small number of taxonomically diverse prokaryotic species have what appears to be a second ATP synthase, in addition to the normal F1F0 ATPase in bacteria and A1A0 ATPase in archaea. These enzymes use ion gradients to synthesize ATP, and in principle may run in either direction. This model represents the F0 subunit A of this apparent second ATP synthase.


Pssm-ID: 132349  Cd Length: 217  Bit Score: 109.83  E-value: 2.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791   26 IPISSTVVTTWFVLFVFYLFFKLGTRNLQ--LIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIFLSNII 103
Cdd:TIGR03306  14 VKINATIAFTWLLMLLLVIGSWLITRRLStgLERSRWQNLLEVLVTGIQEQISDVGLAKPRKYLPFLGTLFLFIAVANLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  104 TffpipwfsikngvfvIYPAFRAPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKGFADPTPVMLPLNVVGEFAKPLN 183
Cdd:TIGR03306  94 S---------------VIPGYEPPTGSLSTTAALALCVFVAVPLFGIAERGLSGYLKSYLKPTPFMLPFNIIGELSRTLA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 492597791  184 ISMRLFGNMFAGMVIMGLIYMAVPYFVPAALHLyFDLFAGLVQSFVFVTLSMVYV 238
Cdd:TIGR03306 159 LAVRLFGNMMSGSMILAILLSISPLIFPVLMQV-LGLLTGMVQAYIFSVLATVYI 212
ATP-synt_Fo_a_6 cd00310
ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms ...
 84-239 1.07e-27

ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms are designated as ATP synthase, Fo complex, subunit a; eukaryotic (chloroplast and mitochondrial) forms are designated as ATP synthase, Fo complex, subunit 6. The F-ATP synthases (also called FoF1-ATPases) consist of two structural domains: F1 (factor one) complex containing the soluble catalytic core, and Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. F-ATP synthase has also been found in the archaea Methanosarcina acetivorans. F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis.


Pssm-ID: 349411 [Multi-domain]  Cd Length: 156  Bit Score: 103.63  E-value: 1.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  84 KKYYTFFASLFLFIFLSNIITFFPIpwfsikngvfviypaFRAPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKGFA 163
Cdd:cd00310    2 KKYLPLLGTLFLFILFSNLLGLIPY---------------SFTPTSHLNVTLALALIVFLGVHILGIKKHGLGFFLHFLP 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 164 D-----PTPVMLPLNVVGEFAKPLNISMRLFGNMFAGMVIMGLIYMAVPY---------FVPAALHLYFDLFAGLVQSFV 229
Cdd:cd00310   67 PgtplpLAPLMVPIELISELIRPLSLSVRLFANMFAGHLLLALLSGLVPSllssvgllpLLLPVALTLLELFVAFIQAYV 146

                        170
                 ....*....|
gi 492597791 230 FVTLSMVYVQ 239
Cdd:cd00310  147 FTLLTAVYIS 156
 
Name Accession Description Interval E-value
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 31-244 1.12e-50

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 164.48  E-value: 1.12e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  31 TVVTTWFVLFVFYLFFKLGTRNLQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIFLSNIITFFPIpw 110
Cdd:COG0356    2 TVLMSWLAMLLLLLLFLLATRKLKLVPGGLQNFVEMLVEFVRNQVKDTIGKKGRKFAPLLLTLFLFILVSNLLGLIPG-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 111 fsikngvfviypaFRAPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKG-FADPT----PVMLPLNVVGEFAKPLNIS 185
Cdd:COG0356   80 -------------LFPPTADINVTLALALIVFVLVHYYGIKKKGLGGYLKHlFFPPFpwlaPLMLPIEIISELARPLSLS 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 492597791 186 MRLFGNMFAGMVIMGLIYMAVPYFVPAAL-------HLYFDLFAGLVQSFVFVTLSMVYVQGSIGD 244
Cdd:COG0356  147 LRLFGNMFAGHIILLLLAGLAPFLLLGVLslllpvaWTAFELLVGFLQAYIFTMLTAVYISLAVEE 212
PRK05815 PRK05815
F0F1 ATP synthase subunit A; Validated
 16-246 1.33e-49

F0F1 ATP synthase subunit A; Validated


Pssm-ID: 235617  Cd Length: 227  Bit Score: 162.27  E-value: 1.33e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  16 GPDIIFSIFGIPISSTVVTTWFVLFVFYLFFKLGTRNLQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFL 95
Cdd:PRK05815   2 EHHLIIGFGGFNFDSLLLSVLLGVLILLLFALVATRKLSGVPGGLQNFVEMIVEFVRGQVKDNIGGKGKKFAPLAFTLFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  96 FIFLSNIITFFPIPWFSikngvfviypafraPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKGF-ADPTPVMLPLNV 174
Cdd:PRK05815  82 FILLMNLLGLIPYLLFP--------------PTADINVTLALALIVFVLVIYYGIKKKGLGGYLKEFyLQPHPLLLPIEI 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 175 VGEFAKPLNISMRLFGNMFAGMVIMGLIYMAVPY--------FVPAALHLYFDLFAGLVQSFVFVTLSMVYVQGSIGDAE 246
Cdd:PRK05815 148 ISEFSRPISLSLRLFGNMLAGELILALIALLGGAglllalapLILPVAWTIFEIFVGTLQAYIFMMLTIVYISMAVEEEH 227
PRK13421 PRK13421
F0F1 ATP synthase subunit A; Provisional
 9-246 1.73e-43

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237383  Cd Length: 223  Bit Score: 146.38  E-value: 1.73e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791   9 TTGPLVSGPdiIFSIFGIPISSTVVTTWFVLFVFYLFFKLGTRNLQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYT 88
Cdd:PRK13421   2 TASPLSTVP--LFSLGPVPISAPVVVTWAIMAVLAAGSALATRRLSLAPGRLQSVLELVVTTIDAQIRDTMQTDPAPYRA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  89 FFASLFLFIFLSNiitffpipWFSIKNGVfviypafRAPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKGFADPTPV 168
Cdd:PRK13421  80 LIGTLFLFVLVAN--------WSSLVPGV-------EPPTAHLETDAALALIVFLATIYYGVRARGVRGYLATFAEPTWV 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492597791 169 MLPLNVVGEFAKPLNISMRLFGNMFAGMVIMGLIYMAVPYFVPAALhLYFDLFAGLVQSFVFVTLSMVYVQGSIGDAE 246
Cdd:PRK13421 145 MIPLNLVEQLTRTFSLIVRLFGNVMSGVFVIGIVLSLAGLLVPIPL-MALDLLTGAVQAYIFAVLAMVFIGAAVSDDE 221
ATP-synt_A pfam00119
ATP synthase A chain;
32-239 1.10e-39

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 136.47  E-value: 1.10e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791   32 VVTTWFVLFVFYLFFKLGTRN-LQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYT-FFASLFLFIFLSNIItffpip 109
Cdd:pfam00119   1 LLMSLIVALILLLFLLLATRKtKKLVPGRLQNFVEMLVEFVDNIVKDNIGKKKGRKFFpLLLTLFFFILVSNLL------ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  110 wfsiknGVFVIYPAFRAPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKGFADP------TPVMLPLNVVGEFAKPLN 183
Cdd:pfam00119  75 ------GLIPKSPGGFTVTADINVTLALALIVFLLVHYYGIKKHGLGGYFKKLFVPpvplplVPLLLPIEIISEFARPVS 148

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492597791  184 ISMRLFGNMFAGMVIMGLIYMAVPYF------------VPAALHLYFDLFAGLVQSFVFVTLSMVYVQ 239
Cdd:pfam00119 149 LSLRLFGNMLAGHLLLLLLAGLIFALlsagfllgvippLLGVAWTLFELLVAFIQAYVFTMLTAVYIS 216
atpI CHL00046
ATP synthase CF0 A subunit
 31-238 5.53e-35

ATP synthase CF0 A subunit


Pssm-ID: 176987  Cd Length: 228  Bit Score: 124.66  E-value: 5.53e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  31 TVVTTWFVLFVFYLFFKLGTRNLQLIPGKFQSVLEGIYEFL-DGTIGQILGVWKKKYYTFFASLFLFIFLSNIITFFpIP 109
Cdd:CHL00046  25 VLITSWVVIAILLGSALLATRNLQTIPTGGQNFFEYVLEFIrDLAKTQIGEEEYRPWVPFIGTMFLFIFVSNWSGAL-LP 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 110 WFSIK--NGVFViypafrAPTADLNTTIGLALIVTTLFISINIKNNGvFGYLKGFADPTPVMLPLNVVGEFAKPLNISMR 187
Cdd:CHL00046 104 WKLIElpHGELA------APTNDINTTVALALLTSVAYFYAGLSKKG-LGYFGKYIQPTPILLPINILEDFTKPLSLSFR 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 492597791 188 LFGNMFAGMVIMGLIYMAVPYFVPAALHLyFDLFAGLVQSFVFVTLSMVYV 238
Cdd:CHL00046 177 LFGNILADELVVAVLVSLVPLVVPIPVMF-LGLFTSGIQALIFATLAAAYI 226
PRK13420 PRK13420
F0F1 ATP synthase subunit A; Provisional
 19-242 5.52e-34

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237382 [Multi-domain]  Cd Length: 226  Bit Score: 122.16  E-value: 5.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  19 IIFSIFGIPISSTVVTTWFVLFVFYLFFKLGTRNLQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIF 98
Cdd:PRK13420   7 VLFHIGPLPITESVLTTWGIMIVLVLASWLTTRRLSLDPGRFQVALEGVVSTIEDAIKEVLPRHARLVLPFVGTLWIFIL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  99 LSNIITffpipwfsikngvfvIYPAFRAPTADLNTTIGLALIVttlFISIN---IKNNGVFGYLKGFADPTPVMLPLNVV 175
Cdd:PRK13420  87 VANLIG---------------LIPGFHSPTADLSVTAALALLV---FFSVHwfgIRAEGLREYLKHYLSPSPFLLPFHLI 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492597791 176 GEFAKPLNISMRLFGNMFAGMVIMGLIYMAVPYFVPAALhLYFDLFAGLVQSFVFVTLSMVYVQGSI 242
Cdd:PRK13420 149 SEITRTLALAVRLFGNIMSLELAALLVLLVAGFLVPVPI-LMLHIIEALVQAYIFGMLALIYIAGGI 214
altF1_A TIGR03306
alternate F1F0 ATPase, F0 subunit A; A small number of taxonomically diverse prokaryotic ...
 26-238 2.21e-29

alternate F1F0 ATPase, F0 subunit A; A small number of taxonomically diverse prokaryotic species have what appears to be a second ATP synthase, in addition to the normal F1F0 ATPase in bacteria and A1A0 ATPase in archaea. These enzymes use ion gradients to synthesize ATP, and in principle may run in either direction. This model represents the F0 subunit A of this apparent second ATP synthase.


Pssm-ID: 132349  Cd Length: 217  Bit Score: 109.83  E-value: 2.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791   26 IPISSTVVTTWFVLFVFYLFFKLGTRNLQ--LIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIFLSNII 103
Cdd:TIGR03306  14 VKINATIAFTWLLMLLLVIGSWLITRRLStgLERSRWQNLLEVLVTGIQEQISDVGLAKPRKYLPFLGTLFLFIAVANLL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  104 TffpipwfsikngvfvIYPAFRAPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKGFADPTPVMLPLNVVGEFAKPLN 183
Cdd:TIGR03306  94 S---------------VIPGYEPPTGSLSTTAALALCVFVAVPLFGIAERGLSGYLKSYLKPTPFMLPFNIIGELSRTLA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 492597791  184 ISMRLFGNMFAGMVIMGLIYMAVPYFVPAALHLyFDLFAGLVQSFVFVTLSMVYV 238
Cdd:TIGR03306 159 LAVRLFGNMMSGSMILAILLSISPLIFPVLMQV-LGLLTGMVQAYIFSVLATVYI 212
ATP-synt_Fo_a_6 cd00310
ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms ...
 84-239 1.07e-27

ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms are designated as ATP synthase, Fo complex, subunit a; eukaryotic (chloroplast and mitochondrial) forms are designated as ATP synthase, Fo complex, subunit 6. The F-ATP synthases (also called FoF1-ATPases) consist of two structural domains: F1 (factor one) complex containing the soluble catalytic core, and Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. F-ATP synthase has also been found in the archaea Methanosarcina acetivorans. F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis.


Pssm-ID: 349411 [Multi-domain]  Cd Length: 156  Bit Score: 103.63  E-value: 1.07e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  84 KKYYTFFASLFLFIFLSNIITFFPIpwfsikngvfviypaFRAPTADLNTTIGLALIVTTLFISINIKNNGVFGYLKGFA 163
Cdd:cd00310    2 KKYLPLLGTLFLFILFSNLLGLIPY---------------SFTPTSHLNVTLALALIVFLGVHILGIKKHGLGFFLHFLP 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 164 D-----PTPVMLPLNVVGEFAKPLNISMRLFGNMFAGMVIMGLIYMAVPY---------FVPAALHLYFDLFAGLVQSFV 229
Cdd:cd00310   67 PgtplpLAPLMVPIELISELIRPLSLSVRLFANMFAGHLLLALLSGLVPSllssvgllpLLLPVALTLLELFVAFIQAYV 146

                        170
                 ....*....|
gi 492597791 230 FVTLSMVYVQ 239
Cdd:cd00310  147 FTLLTAVYIS 156
ATP_synt_6_or_A TIGR01131
ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be ...
 52-242 1.48e-21

ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be designated ATP synthase, F0 subunit A; eukaryotic (chloroplast and mitochondrial) forms should be designated ATP synthase, F0 subunit 6. The F1/F0 ATP synthase is a multisubunit, membrane associated enzyme found in bacteria and mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. Individual subunits in each of these clusters are named differently in prokaryotes and in organelles e.g., mitochondria and chloroplast. The bacterial equivalent of subunit 6 is named subunit 'A'. It has been shown that proton is conducted though this subunit. Typically, deprotonation and reprotonation of the acidic amino acid side-chains are implicated in the process. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273458  Cd Length: 226  Bit Score: 89.19  E-value: 1.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791   52 NLQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIFLSNIITFFPIpWFSikngvfviypafraPTADL 131
Cdd:TIGR01131  36 SRWLIPSRWQNLMESIYEFVLSIVKSQIGGKKGKFFPLIFTLFLFILISNLLGLIPY-SFT--------------PTSHL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  132 NTTIGLALIVTTLFISINIKNN--GVFGYLKGFADPT---PVMLPLNVVGEFAKPLNISMRLFGNMFAGMVIMGLIYMAV 206
Cdd:TIGR01131 101 SFTLGLALPLWLGLTISGFRKHpkGFLAHLVPSGTPLpliPFLVIIETISYLARPISLSVRLFANISAGHLLLTLLSGLL 180

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 492597791  207 PYFVPAALHLY----------FDLFAGLVQSFVFVTLSMVYVQGSI 242
Cdd:TIGR01131 181 FSLMSSAIFALlllilvaliiLEIFVAFIQAYVFTLLTCLYLNDAL 226
PRK13419 PRK13419
F0F1 ATP synthase subunit A; Provisional
 17-238 3.26e-15

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237381  Cd Length: 342  Bit Score: 73.62  E-value: 3.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  17 PDIIFSIFGIPISSTVVTTWFV-----LFVFYLFFKLGTRNLQLIPGKFQSVLEGIYEFLDGTIG-QILGVWKKKYYTFF 90
Cdd:PRK13419  95 PKLVVGGFDISITKHVVMMWIAsaillVVFLAAGRKYKKMTKSQAPKGLANAMEALVEFIRLDVAkSNIGHGYEKFLPYL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  91 ASLFLFIFLSNIITFFPipwfsikngvfviYPAfrapTADLNTTIGLALIVTTLFIS--INIKNNGVFGYLKGFADPTP- 167
Cdd:PRK13419 175 LTVFFFILVCNLLGLVP-------------YGA----TATGNINVTLTLAVFTFFITqyAAIKAHGIKGYLAHLTGGTHw 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 168 ----VMLPLNVVGEFAKPLNISMRLFGNMFAG-MVIMGLIYM---------AVPYFVPAALHLY-FDLFAGLVQSFVFVT 232
Cdd:PRK13419 238 slwiIMIPIEFIGLFTKPFALTVRLFANMTAGhIVILSLIFIsfilksyivAVAVSVPFAIFIYlLELFVAFLQAYIFTM 317


                 ....*.
gi 492597791 233 LSMVYV 238
Cdd:PRK13419 318 LSALFI 323
ATP6 MTH00172
ATP synthase F0 subunit 6; Provisional
 48-242 1.35e-05

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214447  Cd Length: 232  Bit Score: 45.03  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  48 LGTRNLQLIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIFLSNIITFFPIpwfsikngVFviypafrAP 127
Cdd:MTH00172  33 LLFKGIKLIPKRWQSIIEIIYNHFHGVVKDNLGNEGLKYFPFIISLFFFIVFLNLLGLFPY--------VF-------TP 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 128 TADLNTTIGLalivtTLFISINIKNNGVFGYLKGFAD---PT-------PVMLPLNVVGEFAKPLNISMRLFGNMFAG-- 195
Cdd:MTH00172  98 TTHIVVTLGL-----SFSIIIGVTLAGFWRFKWDFFSilmPSgaplglaPLLVLIETVSYISRAISLGVRLAANLSAGhl 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 492597791 196 -----------MVIMGLIYMAVPYFVPAALHLyFDLFAGLVQSFVFVTLSMVYVQGSI 242
Cdd:MTH00172 173 lfailagfgfnMLCASGFLSLFPLLIMVFITL-LEIAVAVIQAYVFCLLTTIYLADTI 229
ATP6 MTH00157
ATP synthase F0 subunit 6; Provisional
 55-237 2.41e-05

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214441  Cd Length: 223  Bit Score: 44.00  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  55 LIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIFLSNIITFFPIpwfsikngVFviypafrAPTADLNTT 134
Cdd:MTH00157  37 LIPSRYNILWNKILKTLHKEFKTLLGPKNKGSTLIFISLFSFILFNNFLGLFPY--------IF-------TSTSHLSLT 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 135 IGLALivtTLFISINIknngvFGYLKGFAD------P--TPVML-PLNVVGE----FAKPLNISMRLFGNMFAGMVIMGL 201
Cdd:MTH00157 102 LSLAL---PLWLSFML-----FGWINNTNHmfahlvPqgTPPILmPFMVLIEtisnLIRPGTLAVRLAANMIAGHLLLTL 173

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 492597791 202 I--------YMAVPYFVPAA-LHLYFDLFAGLVQSFVFVTLSMVY 237
Cdd:MTH00157 174 LgntgpslsSMILSILILIQiLLLILESAVAIIQSYVFSVLSTLY 218
ATP6 MTH00176
ATP synthase F0 subunit 6; Provisional
 55-239 1.89e-04

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214449  Cd Length: 229  Bit Score: 41.56  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  55 LIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIFLSNIITFFPipwfsiknGVFviypafrAPTADLNTT 134
Cdd:MTH00176  40 FCPSKLQVFMLMFSTFLPEMILRSNGSYILGSASIIISLFILVMSLNLSGLIP--------YVF-------TSTSHLVIT 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 135 IGLALIV--TTLFISINIKNNGVFGYLKGFADPT---PVMLPLNVVGEFAKPLNISMRLFGNMFAGMVIMGLIYMAVPYF 209
Cdd:MTH00176 105 LSLALPLwlGVILSGFINNFYSRLSHLVPQGTPPllnPFLVLIELVSLLIRPLTLAVRLAANLSAGHLLLGLLGAAMWGL 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 492597791 210 VP------------AALHLYFDLFAGLVQSFVFVTLSMVYVQ 239
Cdd:MTH00176 185 LPvspligflllivQILYFMFEIAVCMIQAYVFTLLLSLYLD 226
ATP6 MTH00175
ATP synthase F0 subunit 6; Provisional
 55-242 7.43e-04

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177228  Cd Length: 244  Bit Score: 39.60  E-value: 7.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  55 LIPGKFQSVLEGIYEFLDGTIGQILGVWKKKYYTFFASLFLFIFLSNIITFFPIpwfsikngVFViypafraPTADLNTT 134
Cdd:MTH00175  51 LIPNRWQSIMELIYLNIRSVVHDNLGKSGQKYFPFILSLFLFIAILNILGLFPY--------VFT-------PTAHIIIT 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 135 IGLAL---IVTTLFISINIKNNGVFGYLKGFADP--TPVMLPLNVVGEFAKPLNISMRLFGNMFAG-------------M 196
Cdd:MTH00175 116 FGLSLsiiIAVTLLGFLTFKWNFLSILMPGGAPLvlAPFLVLIETLSYLIRAISLGVRLAANISAGhllfailsgfafnM 195

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 492597791 197 VIMGLIYMAVPYFVPAALHLYFDLFAGLVQSFVFVTLSMVYVQGSI 242
Cdd:MTH00175 196 LSNGLIILSLFPMLIMIFITLLEMAVAVIQAYVFCLLTTIYLGDTI 241
PRK13417 PRK13417
F0F1 ATP synthase subunit A; Provisional
 47-238 2.44e-03

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237380  Cd Length: 352  Bit Score: 38.72  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791  47 KLGTRNLQLIPGKFQSVLEGIYEFL-DGTIGQILGVWKKKYYTFFASLFLFIFLSNIITFFP------------------ 107
Cdd:PRK13417 117 NIIAKNPLKVQSRFANTVEVFVNFLrKDIVDESMHGHGHSYYHYIFTLFFFILFCNLMGLVPsvgeltvvasdygglval 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492597791 108 ---------IPWFS-IKNGVfviypafrAPTADLNTTIGLALIVTTLFISINIKNNGV----FGYLKGFADPT-PVMLPL 172
Cdd:PRK13417 197 gvmdhtphaLPTFAkVWSGI--------TVTGDISVTMTLALLTMFLIYGAGFSYQGPkfiwHSVPNGVPLLLyPIMWPL 268

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 492597791 173 N-VVGEFAKPLNISMRLFGNMFAGMVI----MGLIYMA-----VPYFVPAALHLYF-DLFAGLVQSFVFVTLSMVYV 238
Cdd:PRK13417 269 EfIVSPMAKTFALTVRLLANMTAGHVIilalMGFIFQFqswgiVPVSVIGSGLIYVlEIFVAFLQAYIFVLLTSLFV 345
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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