NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|492647822|ref|WP_005910507|]
View 

MULTISPECIES: ribose-phosphate diphosphokinase [Fusobacterium]

Protein Classification

ribose-phosphate diphosphokinase( domain architecture ID 11421473)

ribose-phosphate diphosphokinase catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form the the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP)

CATH:  3.40.50.2020
EC:  2.7.6.1
Gene Ontology:  GO:0002189|GO:0000287|GO:0004749|GO:0005524|GO:0009156|GO:0016301|GO:0016310|GO:0006015|GO:0009165
PubMed:  11751055|7593598

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 4-316 0e+00

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


:

Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 561.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   4 FNNVKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRA 83
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  84 SAKTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKGF 163
Cdd:COG0462   81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 164 lgDNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRG 243
Cdd:COG0462  161 --EDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492647822 244 AKEVYACCSHAVFSDPAIERLEKSALKEVIITDSIALPERKRIDKIRIISVDSVFANAIDRITNNQSVSELFN 316
Cdd:COG0462  239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEKRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 4-316 0e+00

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 561.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   4 FNNVKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRA 83
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  84 SAKTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKGF 163
Cdd:COG0462   81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 164 lgDNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRG 243
Cdd:COG0462  161 --EDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492647822 244 AKEVYACCSHAVFSDPAIERLEKSALKEVIITDSIALPERKRIDKIRIISVDSVFANAIDRITNNQSVSELFN 316
Cdd:COG0462  239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEKRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
7-316 0e+00

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 547.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   7 VKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRASAK 86
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  87 TINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKGFlgD 166
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNL--E 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 167 NVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRGAKE 246
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492647822 247 VYACCSHAVFSDPAIERLEKSALKEVIITDSIALPE-RKRIDKIRIISVDSVFANAIDRITNNQSVSELFN 316
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEeAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 7-315 2.56e-148

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 418.99  E-value: 2.56e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822    7 VKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVV-QSTSEPVNENLMELLIFVDALKRASA 85
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   86 KTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKgfLG 165
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKK--IL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  166 DNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRP-KPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRGA 244
Cdd:TIGR01251 159 DNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492647822  245 KEVYACCSHAVFSDPAIERLEKSALKEVIITDSIalPERKRIDKIRIISVDSVFANAIDRITNNQSVSELF 315
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTI--PHEKHKPKVSVISVAPLIAEAIRRIHNNESVSSLF 307
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 7-123 1.21e-74

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 224.61  E-value: 1.21e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822    7 VKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRASAK 86
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 492647822   87 TINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAG 123
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 150-277 2.33e-23

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 93.23  E-value: 2.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 150 ALPLMARYFKEKgfLGDNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEVM------NLIGEVEGKIAIFID 223
Cdd:cd06223    1 AGRLLAEEIRED--LLEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 492647822 224 DMIDTAGTITNGADAIAQRGAKEVYACCSHAVFSDPAieRLEKSALKEVIITDS 277
Cdd:cd06223   79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 4-316 0e+00

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 561.99  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   4 FNNVKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRA 83
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  84 SAKTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKGF 163
Cdd:COG0462   81 SARRITAVIPYYGYARQDRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSKDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 164 lgDNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRG 243
Cdd:COG0462  161 --EDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCIIVDDMIDTGGTLVEAAEALKEAG 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 492647822 244 AKEVYACCSHAVFSDPAIERLEKSALKEVIITDSIALPERKRIDKIRIISVDSVFANAIDRITNNQSVSELFN 316
Cdd:COG0462  239 AKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEKRCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
7-316 0e+00

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 547.79  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   7 VKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRASAK 86
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  87 TINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKGFlgD 166
Cdd:PRK01259  81 RITAVIPYFGYARQDRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQKNL--E 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 167 NVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRGAKE 246
Cdd:PRK01259 159 NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKS 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492647822 247 VYACCSHAVFSDPAIERLEKSALKEVIITDSIALPE-RKRIDKIRIISVDSVFANAIDRITNNQSVSELFN 316
Cdd:PRK01259 239 VYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEeAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
4-315 1.61e-161

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 452.71  E-value: 1.61e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   4 FNNVKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRA 83
Cdd:PRK02269   3 YSDLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  84 SAKTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKGF 163
Cdd:PRK02269  83 SAESINVVMPYYGYARQDRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 164 LGDNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRP--KPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQ 241
Cdd:PRK02269 163 VGDDVVVVSPDHGGVTRARKLAQFLKTPIAIIDKRRSvdKMNTSEVMNIIGNVKGKKCILIDDMIDTAGTICHAADALAE 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492647822 242 RGAKEVYACCSHAVFSDPAIERLEKSALKEVIITDSIALPERKRIDKIRIISVDSVFANAIDRITNNQSVSELF 315
Cdd:PRK02269 243 AGATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIYLPEERLIDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 7-315 2.56e-148

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 418.99  E-value: 2.56e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822    7 VKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVV-QSTSEPVNENLMELLIFVDALKRASA 85
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   86 KTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKgfLG 165
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKK--IL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  166 DNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRP-KPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRGA 244
Cdd:TIGR01251 159 DNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492647822  245 KEVYACCSHAVFSDPAIERLEKSALKEVIITDSIalPERKRIDKIRIISVDSVFANAIDRITNNQSVSELF 315
Cdd:TIGR01251 239 KRVIAAATHGVFSGPAIERIANAGVEEVIVTNTI--PHEKHKPKVSVISVAPLIAEAIRRIHNNESVSSLF 307
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 17-316 7.23e-148

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 417.56  E-value: 7.23e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  17 ELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRASAKTINVIIPYYG 96
Cdd:PLN02369   2 ALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  97 YARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKGFLGDNVVVVSPDVG 176
Cdd:PLN02369  82 YARADRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVVSPDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 177 GVKRARKLAEKL-DCKIAIIDKRRPKPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRGAKEVYACCSHAV 255
Cdd:PLN02369 162 GVARARAFAKKLsDAPLAIVDKRRQGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAV 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 492647822 256 FSDPAIERLEKSALKEVIITDSIALPERKRIDKIRIISVDSVFANAIDRITNNQSVSELFN 316
Cdd:PLN02369 242 FSPPAIERLSSGLFQEVIVTNTIPVSEKNYFPQLTVLSVANLLGETIWRVHDDCSVSSIFD 302
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 5-315 4.19e-142

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 404.12  E-value: 4.19e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   5 NNVKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRAS 84
Cdd:PRK02812  20 NRLRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRAS 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  85 AKTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKGfL 164
Cdd:PRK02812 100 ARQITAVIPYYGYARADRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLASKN-L 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 165 GDnVVVVSPDVGGVKRARKLAEKL-DCKIAIIDKRRPKPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRG 243
Cdd:PRK02812 179 ED-IVVVSPDVGGVARARAFAKKLnDAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEG 257

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492647822 244 AKEVYACCSHAVFSDPAIERLEKSALKEVIITDSIALPERKRIDKIRIISVDSVFANAIDRITNNQSVSELF 315
Cdd:PRK02812 258 AKQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIPVPEERRFPQLKVLSVANMLGEAIWRIHEESSVSSMF 329
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
18-316 2.34e-129

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 370.82  E-value: 2.34e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  18 LAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRASAKTINVIIPYYGY 97
Cdd:PRK03092   1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  98 ARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKgFLGDNVVVVSPDVGG 177
Cdd:PRK03092  81 ARQDKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDK-YDLDNVTVVSPDAGR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 178 VKRARKLAEKL-DCKIAIIDKRRP--KPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRGAKEVYACCSHA 254
Cdd:PRK03092 160 VRVAEQWADRLgGAPLAFIHKTRDptVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHG 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492647822 255 VFSDPAIERLEKSALKEVIITDSIALPERKRIDKIRIISVDSVFANAIDRITNNQSVSELFN 316
Cdd:PRK03092 240 VLSGPAAERLKNCGAREVVVTDTLPIPEEKRFDKLTVLSIAPLLARAIREVFEDGSVTSLFD 301
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 6-315 7.13e-128

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 367.91  E-value: 7.13e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   6 NVKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRASA 85
Cdd:PRK02458   9 QIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRASA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  86 KTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKGFLG 165
Cdd:PRK02458  89 NTVNVVLPYFGYARQDRIAKPREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAKHYCKKGLSG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 166 DNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEVMnLIGEVEGKIAIFIDDMIDTAGTITNGADAIAQRGAK 245
Cdd:PRK02458 169 SDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSEREEGY-IIGDVAGKKAILIDDILNTGKTFAEAAKIVEREGAT 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 246 EVYACCSHAVFSDPAIERLEKSALKEVIITDSIALPERKRIDkIRIISVDSVFANAIDRITNNQSVSELF 315
Cdd:PRK02458 248 EIYAVASHGLFAGGAAEVLENAPIKEILVTDSVATKERVPKN-VTYLSASELIADAIIRIHERKPLSPLF 316
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
1-315 1.53e-124

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 359.24  E-value: 1.53e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   1 MINFNNVKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDAL 80
Cdd:PRK04923   1 MQDQRNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  81 KRASAKTINVIIPYYGYARQDRKSKP-REPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQALP-LMARYF 158
Cdd:PRK04923  81 KRASAASVTAVIPYFGYSRQDRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPlLLADIW 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 159 KEKGFlgDNVVVVSPDVGGVKRARKLAEKL-DCKIAIIDKRRPKPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGAD 237
Cdd:PRK04923 161 RAYGT--DNLIVVSPDVGGVVRARAVAKRLdDADLAIIDKRRPRANVATVMNIIGDVQGKTCVLVDDLVDTAGTLCAAAA 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 492647822 238 AIAQRGAKEVYACCSHAVFSDPAIERLEKSALKEVIITDSIALPERKRI-DKIRIISVDSVFANAIDRITNNQSVSELF 315
Cdd:PRK04923 239 ALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARAcAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 6-316 2.89e-109

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 324.52  E-value: 2.89e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   6 NVKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRASA 85
Cdd:PTZ00145 119 NAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRASA 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  86 KTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFD--IPVDHMQALPLMARYFKEKGF 163
Cdd:PTZ00145 199 KKITAVIPYYGYARQDRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQLIGLDYFTKKDL 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 164 LgdNVVVVSPDVGGVKRARKLAEKL------DCKIAIIDKRRPKPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGAD 237
Cdd:PTZ00145 279 Y--KPVIVSPDAGGVYRARKFQDGLnhrgisDCGIAMLIKQRTKPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAAK 356

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 238 AIAQRGAKEVYACCSHAVFSDPAIERLEKSALKEVIITDSI-ALPERKRIDKIRIISVDSVFANAIDRITNNQSVSELFN 316
Cdd:PTZ00145 357 QLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVkSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDLFN 436
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 1-315 3.14e-109

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 320.71  E-value: 3.14e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   1 MINFNNVkIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDAL 80
Cdd:PRK00553   5 IDKSNHV-IFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  81 KRASAKTINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGVNRIVTMDLHADQIQGFFDIPVDHMQA-LPLMARYFK 159
Cdd:PRK00553  84 KRGSAKSITAILPYYGYARQDRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTyHVFLSRVLE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 160 EKGFlgDNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEVMNLIGEVEGKIAIFIDDMIDTAGTITNGADAI 239
Cdd:PRK00553 164 LLGK--KDLVVVSPDYGGVKRARLIAESLELPLAIIDKRRPKHNVAESINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 240 AQRGAKEVYACCSHAVFSDPAIERLEKSALKEVI----ITDSIALPERKRIDKIRIISVDSVFANAIDRITNNQSVSELF 315
Cdd:PRK00553 242 KKQKAKKVCVMATHGLFNKNAIQLFDEAFKKKLIdklfVSNSIPQTKFEKKPQFKVVDLAHLYEEVLLCYANGGSISAIY 321
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 8-302 3.29e-75

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 232.11  E-value: 3.29e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   8 KIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSePVNENLMELLIFVDALKRASAKT 87
Cdd:PRK00934   1 MIIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTY-PQDENLVELLLLIDALRDEGAKS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  88 INVIIPYYGYARQDRKSKPREPITSKLVANLLTTAGvNRIVTMDLHADQIQGFFDIPVDHMQALPLMARYFKEKgflGDN 167
Cdd:PRK00934  80 ITLVIPYLGYARQDKRFKPGEPISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDK---LDD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 168 VVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAE--VMNLigEVEGKIAIFIDDMIDTAGTITNGADAIAQRGAK 245
Cdd:PRK00934 156 PLVLAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEiaPKNL--DVKGKDVLIVDDIISTGGTMATAIKILKEQGAK 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 492647822 246 EVYACCSHAVFSDPAIERLEKSALKEVIITDSIALPERKridkiriISVDSVFANAI 302
Cdd:PRK00934 234 KVYVACVHPVLVGDAILKLYNAGVDEIIVTDTLESEVSK-------ISVAPLIADLL 283
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 7-123 1.21e-74

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 224.61  E-value: 1.21e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822    7 VKIFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPVNENLMELLIFVDALKRASAK 86
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 492647822   87 TINVIIPYYGYARQDRKSKPREPITSKLVANLLTTAG 123
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDKPREPITAKLVADLLEAAG 117
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
9-302 1.76e-46

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 158.95  E-value: 1.76e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822   9 IFSGNSNLELAKKIAEKAGLQLGKAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSEPvNENLMELLIFVDALKRASAKTI 88
Cdd:PRK07199   5 LLALPGNEAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCSLDRP-DEKLLPLLFAAEAARELGARRV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  89 NVIIPYYGYARQDRKSKPREPITSKLVANLLTTAgVNRIVTMD--LH-ADQIQGFFDIPVDHMQALPLMARYFKEKgflG 165
Cdd:PRK07199  84 GLVAPYLAYMRQDIAFHPGEAISQRHFARLLSGS-FDRLVTVDphLHrYPSLSEVYPIPAVVLSAAPAIAAWIRAH---V 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 166 DNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEV--MNLIgEVEGKIAIFIDDMIDTAGTITNGADAIAQRG 243
Cdd:PRK07199 160 PRPLLIGPDEESEQWVAAVAERAGAPHAVLRKTRHGDRDVEIslPDAA-PWAGRTPVLVDDIVSTGRTLIEAARQLRAAG 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 492647822 244 AKEVYACCSHAVFSDPAIERLEKSALKEVIITDSIALPERKridkiriISVDSVFANAI 302
Cdd:PRK07199 239 AASPDCVVVHALFAGDAYSALAAAGIARVVSTDTVPHPSNA-------ISLAPLLAEAL 290
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 32-316 8.15e-43

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 151.26  E-value: 8.15e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  32 KAEIQRFKDGEVYIEIEETVRGRDVFVVQSTSE--------------PVNENLMELLIFVDALkRASAKTINVIIPYYGY 97
Cdd:PRK06827  56 PAKFIRFSNGEAKGEILESVRGKDIYILQDVGNysvtynmfgeknhmSPDDHFQDLKRTIDAI-RGKARRITVIMPFLYE 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  98 ARQDRKSKpREPITSKLVANLLTTAGVNRIVTMDLHADQIQgffdipvdhmQALPLM------ARYFKEKGFL------- 164
Cdd:PRK06827 135 SRQHKRKG-RESLDCALALQELEELGVDNIITFDAHDPRIE----------NAIPLMgfenlyPSYQIIKALLknekdle 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 165 --GDNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAE------VMNLIGE-VEGKIAIFIDDMIDTAGTITNG 235
Cdd:PRK06827 204 idKDHLMVISPDTGAMDRAKYYASVLGVDLGLFYKRRDYSRVVNgrnpivAHEFLGRdVEGKDVLIVDDMIASGGSMIDA 283

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 236 ADAIAQRGAKEVYACCSHAVFSDpAIERLEKsALKE-----VIITDSIALPErKRIDKIRIISVD--SVFANAIDRITNN 308
Cdd:PRK06827 284 AKELKSRGAKKIIVAATFGFFTN-GLEKFDK-AYEEgyfdrIIGTNLVYHPE-ELLSKPWYIEVDmsKLIARIIDALNHD 360


                 ....*...
gi 492647822 309 QSVSELFN 316
Cdd:PRK06827 361 VSLSKLLD 368
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 167-315 3.08e-26

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 102.20  E-value: 3.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  167 NVVVVSPDVGGVKRARKLAEKLDCKIAII------------DKRRPKPNVAEV------------------MNLIGEVEG 216
Cdd:pfam14572   4 NAVIVARSPGSAKRATSFAERLRLGIAVIhgeqkeaesdevDGRQSPPPYRSRtvsrslglpeiipkekppMTVVGDVGG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  217 KIAIFIDDMIDTAGTITNGADAIAQRGAKEVYACCSHAVFSDPAIERLEKSALKEVIITDSIALPERK-RIDKIRIISVD 295
Cdd:pfam14572  84 RIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKmQCHKIKTIDIS 163

                         170       180
                  ....*....|....*....|
gi 492647822  296 SVFANAIDRITNNQSVSELF 315
Cdd:pfam14572 164 QLIAEAIRRIHNGESMSYLF 183
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 150-277 2.33e-23

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 93.23  E-value: 2.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 150 ALPLMARYFKEKgfLGDNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEVM------NLIGEVEGKIAIFID 223
Cdd:cd06223    1 AGRLLAEEIRED--LLEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 492647822 224 DMIDTAGTITNGADAIAQRGAKEVYACCSHAVFSDPAieRLEKSALKEVIITDS 277
Cdd:cd06223   79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 142-276 4.16e-15

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 71.24  E-value: 4.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  142 DIPVDHMQALPLMARYFKEK--GFLGDNVVVVSPDVGGVKRARKLAEKLDCKIAIIDKRRPKPNVAEVM---NLIGEVEG 216
Cdd:pfam00156   3 DEILDNPAILKAVARLAAQIneDYGGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDTSEVMktsSALPDLKG 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  217 KIAIFIDDMIDTAGTITNGADAIAQRGAKEVYACCSHavfsDPAIERLEKSALKEVIITD 276
Cdd:pfam00156  83 KTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLI----DKPAGTEPKDKYDKRVDDW 138
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 17-280 3.00e-14

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 72.03  E-value: 3.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  17 ELAKKIAEKAG-LQLGKAEIQRFKDG--EVYIEIEETVRGRDVFVVQSTSEPvnENLMELLIFVDALKRASAKTINVIIP 93
Cdd:PLN02297  27 ELARKIAAESDaIELGSINWRKFPDGfpNLFINNAHGIRGQHVAFLASFSSP--AVIFEQLSVIYALPKLFVASFTLVLP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822  94 YYGYARQDRKSKPREPITSKLVANLLTT-----AGVNRIVTMDLHA--------DQIQGFFD--IPV--DHMQALPLmar 156
Cdd:PLN02297 105 FFPTGTSERVEREGDVATAFTLARILSNipisrGGPTSLVIFDIHAlqerfyfgDNVLPCFEsgIPLlkKRLQQLPD--- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492647822 157 yfkekgflGDNVVVVSPDVGGVKRARKLAEKLDC----KIAIIDKR--RPKPnvaevmnliGEVEGKIAIFIDDMIDTAG 230
Cdd:PLN02297 182 --------SDNIVIAFPDDGAWKRFHKQFEHFPMvvctKVREGDKRivRIKE---------GNPAGRHVVIVDDLVQSGG 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 492647822 231 TITNGADAIAQRGAKEVYACCSHAVFSDPAIERLEKS------ALKEVIITDSIAL 280
Cdd:PLN02297 245 TLIECQKVLAAHGAAKVSAYVTHGVFPNESWERFTHDnggpeaGFAYFWITDSCPQ 300
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH