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Conserved domains on  [gi|492834064|ref|WP_005988018|]
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glycosyltransferase family 2 protein [Xanthomonas vesicatoria]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10118426)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  9445404|12691742|10508766|12200473|10521532
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 12-239 1.04e-80

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


:

Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 242.58  E-value: 1.04e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  12 RISACIIAFNEADRLRDCLTSLAFC-DEIVVVDSGSTDATAAIASAHGARVLHRAFDGYRSQKAYCVEQAHHDWVLCLDA 90
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAvDEIIVVDSGSTDRTVEIAKEYGAKVYQRWWDGFGAQRNFALELATNDWVLSLDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  91 DERISESLRAAILAARDAGfaDAAGYRFARLSEYFGRFLRHGNAYPDRVLRLFDrRRGGWRGKREIHEAASVDG-AVVTL 169
Cdd:cd02511   81 DERLTPELADEILALLATD--DYDGYYVPRRNFFLGRWIRHGGWYPDRQLRLFR-RGKARFEDGRVHEQVVVDGgVGIVL 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492834064 170 RGDLIHYPYRSLMQQLAKTQRYAQMMAEHDYARGKRATWSKLVLA--PAWRFWRGYLLRGGFRDGWHGLIYA 239
Cdd:cd02511  158 KGDILHYGYKSLEEFLEKHNRYSSLEAKDLAAKGKKRSLLKGLLLgrPLLAFLKMYILKRGFLDGRAGFILA 229
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 12-239 1.04e-80

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 242.58  E-value: 1.04e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  12 RISACIIAFNEADRLRDCLTSLAFC-DEIVVVDSGSTDATAAIASAHGARVLHRAFDGYRSQKAYCVEQAHHDWVLCLDA 90
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAvDEIIVVDSGSTDRTVEIAKEYGAKVYQRWWDGFGAQRNFALELATNDWVLSLDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  91 DERISESLRAAILAARDAGfaDAAGYRFARLSEYFGRFLRHGNAYPDRVLRLFDrRRGGWRGKREIHEAASVDG-AVVTL 169
Cdd:cd02511   81 DERLTPELADEILALLATD--DYDGYYVPRRNFFLGRWIRHGGWYPDRQLRLFR-RGKARFEDGRVHEQVVVDGgVGIVL 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492834064 170 RGDLIHYPYRSLMQQLAKTQRYAQMMAEHDYARGKRATWSKLVLA--PAWRFWRGYLLRGGFRDGWHGLIYA 239
Cdd:cd02511  158 KGDILHYGYKSLEEFLEKHNRYSSLEAKDLAAKGKKRSLLKGLLLgrPLLAFLKMYILKRGFLDGRAGFILA 229
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 10-143 2.10e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 91.69  E-value: 2.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  10 RPRISACIIAFNEADRLRDCLTSLA----FCDEIVVVDSGSTDATAAIASAHGAR------VLHRAFDGYRSQKAYCVEQ 79
Cdd:COG0463    1 MPLVSVVIPTYNEEEYLEEALESLLaqtyPDFEIIVVDDGSTDGTAEILRELAAKdprirvIRLERNRGKGAARNAGLAA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492834064  80 AHHDWVLCLDADERISESLRAAILAARDAGFAD-AAGYRFARLSEYFGRFLRHGNAYPDRVLRLF 143
Cdd:COG0463   81 ARGDYIAFLDADDQLDPEKLEELVAALEEGPADlVYGSRLIREGESDLRRLGSRLFNLVRLLTNL 145
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 14-131 6.52e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 73.20  E-value: 6.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064   14 SACIIAFNEADRLRDCLTSLA----FCDEIVVVDSGSTDATAAIASAH-----GARVLHRAF-DGYRSQKAYCVEQAHHD 83
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLnqtyPNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLPEnRGKAGARNAGLRAATGD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 492834064   84 WVLCLDADERIS-ESLRAAILAARDAGFADAAGYRFARLSEYFGRFLRH 131
Cdd:pfam00535  81 YIAFLDADDEVPpDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRAS 129
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 13-119 2.57e-15

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 72.93  E-value: 2.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064   13 ISACIIAFNEADRLRDCLTSLAFCD---EIVVVDSGSTDATAAIASAHGARVLH----RAFdgyrsQKAYCVEQAHHDWV 85
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLADLQALRgdaEVIVVDGGSTDGTVEIARSLGAKVIHspkgRAR-----QMNAGAALAKGDIL 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 492834064   86 LCLDADERISESLRAAILAARDAGFADAAGYRFA 119
Cdd:TIGR04283  76 LFLHADTRLPKDFLEAIRRALAKPGYVAGAFDLR 109
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 12-65 1.85e-10

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 60.32  E-value: 1.85e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  12 RISACIIAFNEADRLRDCLTSLA------FCDEIVVVDSGSTDATAAIASAHGARVLHRA 65
Cdd:PRK13915  32 TVSVVLPALNEEETVGKVVDSIRpllmepLVDELIVIDSGSTDATAERAAAAGARVVSRE 91
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 12-239 1.04e-80

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 242.58  E-value: 1.04e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  12 RISACIIAFNEADRLRDCLTSLAFC-DEIVVVDSGSTDATAAIASAHGARVLHRAFDGYRSQKAYCVEQAHHDWVLCLDA 90
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAvDEIIVVDSGSTDRTVEIAKEYGAKVYQRWWDGFGAQRNFALELATNDWVLSLDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  91 DERISESLRAAILAARDAGfaDAAGYRFARLSEYFGRFLRHGNAYPDRVLRLFDrRRGGWRGKREIHEAASVDG-AVVTL 169
Cdd:cd02511   81 DERLTPELADEILALLATD--DYDGYYVPRRNFFLGRWIRHGGWYPDRQLRLFR-RGKARFEDGRVHEQVVVDGgVGIVL 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492834064 170 RGDLIHYPYRSLMQQLAKTQRYAQMMAEHDYARGKRATWSKLVLA--PAWRFWRGYLLRGGFRDGWHGLIYA 239
Cdd:cd02511  158 KGDILHYGYKSLEEFLEKHNRYSSLEAKDLAAKGKKRSLLKGLLLgrPLLAFLKMYILKRGFLDGRAGFILA 229
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 10-143 2.10e-22

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 91.69  E-value: 2.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  10 RPRISACIIAFNEADRLRDCLTSLA----FCDEIVVVDSGSTDATAAIASAHGAR------VLHRAFDGYRSQKAYCVEQ 79
Cdd:COG0463    1 MPLVSVVIPTYNEEEYLEEALESLLaqtyPDFEIIVVDDGSTDGTAEILRELAAKdprirvIRLERNRGKGAARNAGLAA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492834064  80 AHHDWVLCLDADERISESLRAAILAARDAGFAD-AAGYRFARLSEYFGRFLRHGNAYPDRVLRLF 143
Cdd:COG0463   81 ARGDYIAFLDADDQLDPEKLEELVAALEEGPADlVYGSRLIREGESDLRRLGSRLFNLVRLLTNL 145
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 14-131 6.52e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 73.20  E-value: 6.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064   14 SACIIAFNEADRLRDCLTSLA----FCDEIVVVDSGSTDATAAIASAH-----GARVLHRAF-DGYRSQKAYCVEQAHHD 83
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLnqtyPNFEIIVVDDGSTDGTVEIAEEYakkdpRVRVIRLPEnRGKAGARNAGLRAATGD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 492834064   84 WVLCLDADERIS-ESLRAAILAARDAGFADAAGYRFARLSEYFGRFLRH 131
Cdd:pfam00535  81 YIAFLDADDEVPpDWLEKLVEALEEDGADVVVGSRYVIFGETGEYRRAS 129
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 7-115 2.48e-15

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 74.39  E-value: 2.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064   7 PDERPRISACIIAFNEADRLRDCLTSLA------FCDEIVVVDSGSTDATAAIASAHGA-----RVLHRAFD-GYRSQKA 74
Cdd:COG1215   25 PADLPRVSVIIPAYNEEAVIEETLRSLLaqdypkEKLEVIVVDDGSTDETAEIARELAAeyprvRVIERPENgGKAAALN 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 492834064  75 YCVEQAHHDWVLCLDADERISES-LRAAILAARDAGfADAAG 115
Cdd:COG1215  105 AGLKAARGDIVVFLDADTVLDPDwLRRLVAAFADPG-VGASG 145
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 13-119 2.57e-15

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 72.93  E-value: 2.57e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064   13 ISACIIAFNEADRLRDCLTSLAFCD---EIVVVDSGSTDATAAIASAHGARVLH----RAFdgyrsQKAYCVEQAHHDWV 85
Cdd:TIGR04283   1 LSIIIPVLNEAATLPELLADLQALRgdaEVIVVDGGSTDGTVEIARSLGAKVIHspkgRAR-----QMNAGAALAKGDIL 75

                          90       100       110
                  ....*....|....*....|....*....|....
gi 492834064   86 LCLDADERISESLRAAILAARDAGFADAAGYRFA 119
Cdd:TIGR04283  76 LFLHADTRLPKDFLEAIRRALAKPGYVAGAFDLR 109
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 17-143 9.19e-13

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 64.45  E-value: 9.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  17 IIAFNEADRLRDCLTSLAFCD----EIVVVDSGSTDATAAIASAHGA------RVLHRAFDGYRSQKAYCVEQAHHDWVL 86
Cdd:cd00761    3 IPAYNEEPYLERCLESLLAQTypnfEVIVVDDGSTDGTLEILEEYAKkdprviRVINEENQGLAAARNAGLKAARGEYIL 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492834064  87 CLDADERIS-ESLRAAILAARDAGFADAAG------YRFARLSEYFGRFLRHGNAYPDRVLRLF 143
Cdd:cd00761   83 FLDADDLLLpDWLERLVAELLADPEADAVGgpgnllFRRELLEEIGGFDEALLSGEEDDDFLLR 146
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 13-118 7.82e-12

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 63.36  E-value: 7.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  13 ISACIIAFNEADRLRDCLTSLA----FCDEIVVVDSGSTDATAAIASAHGARVLH----RAfdgyrSQKAYCVEQAHHDW 84
Cdd:cd02522    1 LSIIIPTLNEAENLPRLLASLRrlnpLPLEIIVVDGGSTDGTVAIARSAGVVVISspkgRA-----RQMNAGAAAARGDW 75

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 492834064  85 VLCLDADERIS-ESLRAAILAARDAGfADAAGYRF 118
Cdd:cd02522   76 LLFLHADTRLPpDWDAAIIETLRADG-AVAGAFRL 109
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
10-105 1.50e-10

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 59.24  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  10 RPRISACIIAFNEADRLRDCLTSLA----FCDEIVVVDSGSTDATAAIASAH---GARVLHRAFD-GYRSQKAYCVEQAH 81
Cdd:COG1216    2 RPKVSVVIPTYNRPELLRRCLESLLaqtyPPFEVIVVDNGSTDGTAELLAALafpRVRVIRNPENlGFAAARNLGLRAAG 81

                         90       100
                 ....*....|....*....|....
gi 492834064  82 HDWVLCLDADERISESLRAAILAA 105
Cdd:COG1216   82 GDYLLFLDDDTVVEPDWLERLLAA 105
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 12-65 1.85e-10

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 60.32  E-value: 1.85e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  12 RISACIIAFNEADRLRDCLTSLA------FCDEIVVVDSGSTDATAAIASAHGARVLHRA 65
Cdd:PRK13915  32 TVSVVLPALNEEETVGKVVDSIRpllmepLVDELIVIDSGSTDATAERAAAAGARVVSRE 91
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 19-116 1.86e-10

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 58.39  E-value: 1.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  19 AFNEADRLRDCLTSLAFCD----EIVVVDSGSTDATAAIASAHGA---RVLHRAFDGYRSQKA----YCVEQAHHDWVLC 87
Cdd:cd06423    5 AYNEEAVIERTIESLLALDypklEVIVVDDGSTDDTLEILEELAAlyiRRVLVVRDKENGGKAgalnAGLRHAKGDIVVV 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 492834064  88 LDADERISES--LRAAILAARDAGFADAAGY 116
Cdd:cd06423   85 LDADTILEPDalKRLVVPFFADPKVGAVQGR 115
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 7-112 2.77e-10

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 59.13  E-value: 2.77e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064   7 PDERPRISACIIAFNEADRLRDCLTSLAFCD------EIVVVDSGSTDATAAIASAHGARVLHRAFDGYRSQKAY----C 76
Cdd:cd06439   25 PAYLPTVTIIIPAYNEEAVIEAKLENLLALDyprdrlEIIVVSDGSTDGTAEIAREYADKGVKLLRFPERRGKAAalnrA 104

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 492834064  77 VEQAHHDWVLCLDADERIS-ESLRAAIlaardAGFAD 112
Cdd:cd06439  105 LALATGEIVVFTDANALLDpDALRLLV-----RHFAD 136
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 19-131 1.05e-09

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 56.43  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  19 AFNEADRLRDCLTSL------AFCDEIVVVDSGSTDATAAIASAHGA-----RVLHRAFD-GYrsQKAY--CVEQAHHDW 84
Cdd:cd04179    5 AYNEEENIPELVERLlavleeGYDYEIIVVDDGSTDGTAEIARELAArvprvRVIRLSRNfGK--GAAVraGFKAARGDI 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 492834064  85 VLCLDAD-----ERISEslraaILAARDAGFADAA-GYRFARLSEYFGRFLRH 131
Cdd:cd04179   83 VVTMDADlqhppEDIPK-----LLEKLLEGGADVViGSRFVRGGGAGMPLLRR 130
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 12-115 1.40e-08

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 54.16  E-value: 1.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  12 RISACIIAFNEADRLRDCLTSL------AFCDEIVVVDSGSTDATAAIASAHGA-----RVLHRAfdgYRSQKA---YCV 77
Cdd:cd02525    1 FVSIIIPVRNEEKYIEELLESLlnqsypKDLIEIIVVDGGSTDGTREIVQEYAAkdpriRLIDNP---KRIQSAglnIGI 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 492834064  78 EQAHHDWVLCLDADERISESLRAAILAARDAGFADAAG 115
Cdd:cd02525   78 RNSRGDIIIRVDAHAVYPKDYILELVEALKRTGADNVG 115
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 17-91 7.17e-07

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 48.82  E-value: 7.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  17 IIAF-NEADRLRDCLTSLAFCD------EIVVVDSGSTDATAAI---ASAHGARVLHRAFDGYRSQK------AYCVEQA 80
Cdd:cd04192    2 VIAArNEAENLPRLLQSLSALDypkekfEVILVDDHSTDGTVQIlefAAAKPNFQLKILNNSRVSISgkknalTTAIKAA 81

                         90
                 ....*....|.
gi 492834064  81 HHDWVLCLDAD 91
Cdd:cd04192   82 KGDWIVTTDAD 92
EpsO_like cd06438
EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is ...
 17-117 3.51e-06

EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.


Pssm-ID: 133060 [Multi-domain]  Cd Length: 183  Bit Score: 46.44  E-value: 3.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  17 IIAFNEADRLRDCLTSLAFCD------EIVVVDSGSTDATAAIASAHGARVLHRaFDGYRSQKAYCVE---------QAH 81
Cdd:cd06438    3 IPAHNEEAVIGNTVRSLKAQDyprelyRIFVVADNCTDDTAQVARAAGATVLER-HDPERRGKGYALDfgfrhllnlADD 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 492834064  82 HDWVLCLDADERISESLRAAILAARDAGFADAAGYR 117
Cdd:cd06438   82 PDAVVVFDADNLVDPNALEELNARFAAGARVVQAYY 117
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 11-143 1.51e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 45.05  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064   11 PRISACIIAFNEADRLRDCLTSLAFCD----EIVVVDSGSTDATAAIASAHGA-------RVLHRA----FDGYRSQKAY 75
Cdd:pfam13641   2 PDVSVVVPAFNEDSVLGRVLEAILAQPyppvEVVVVVNPSDAETLDVAEEIAArfpdvrlRVIRNArllgPTGKSRGLNH 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492834064   76 CVEQAHHDWVLCLDADERISESLRAAILAardagFADAAGYRFARLSEyfgrFLRHGNAYPDRVLRLF 143
Cdd:pfam13641  82 GFRAVKSDLVVLHDDDSVLHPGTLKKYVQ-----YFDSPKVGAVGTPV----FSLNRSTMLSALGALE 140
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 17-113 2.19e-05

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 44.48  E-value: 2.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  17 IIAFNEADRLRDCLTSL--------AFCDEIVVVDSGSTDATAAIASAHGARvlhrafdgyrsqkaycveqaHHDWVLCL 88
Cdd:cd04188    3 IPAYNEEKRLPPTLEEAveyleerpSFSYEIIVVDDGSKDGTAEVARKLARK--------------------NPALIRVL 62

                         90       100
                 ....*....|....*....|....*....
gi 492834064  89 DADERI--SESLRAAILAARD--AGFADA 113
Cdd:cd04188   63 TLPKNRgkGGAVRAGMLAARGdyILFADA 91
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 17-91 3.12e-05

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 44.06  E-value: 3.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  17 II-AFNEAD-------RLRDCLTSLAFcdEIVVVDSGSTDATAAIASAHGA-----RVLHRAFDGYRSqKAYcVE---QA 80
Cdd:cd06442    2 IIpTYNEREnipelieRLDAALKGIDY--EIIVVDDNSPDGTAEIVRELAKeyprvRLIVRPGKRGLG-SAY-IEgfkAA 77

                         90
                 ....*....|.
gi 492834064  81 HHDWVLCLDAD 91
Cdd:cd06442   78 RGDVIVVMDAD 88
Glyco_tranf_2_4 pfam13704
Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative ...
 21-92 7.73e-05

Glycosyl transferase family 2; Members of this family of prokaryotic proteins include putative glucosyltransferases,


Pssm-ID: 433416 [Multi-domain]  Cd Length: 97  Bit Score: 40.69  E-value: 7.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064   21 NEADRLRDCLT--SLAFCDEIVVVDSGSTDATAAIASAHGA---RVLHRAFDGYRSQKAY---CVEQAHH-DWVLCLDAD 91
Cdd:pfam13704   2 NEADILPQWLAhhLALGFDHIYVYDNGSDDGTAEILARLPDvsiLRSDLSYKDARFQVDWrnaLLARYAEaDWVLVVDAD 81


                  .
gi 492834064   92 E 92
Cdd:pfam13704  82 E 82
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 17-117 1.20e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 38.69  E-value: 1.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  17 IIAFNEADRLRDCLTSLA---FCD-EIVVVDSGSTDATAAIASAHGARV-LHRA-----FDGYRSQkayCVEQAHHDWVL 86
Cdd:cd04186    3 IVNYNSLEYLKACLDSLLaqtYPDfEVIVVDNASTDGSVELLRELFPEVrLIRNgenlgFGAGNNQ---GIREAKGDYVL 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 492834064  87 CLDADERISE-SLRAAILAARDAGFADAAGYR 117
Cdd:cd04186   80 LLNPDTVVEPgALLELLDAAEQDPDVGIVGPK 111
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 17-63 2.80e-03

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 37.91  E-value: 2.80e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 492834064  17 IIAFNEADRLRDCLTSLA---FCD-EIVVVDSGSTDATAAIASAHGARVLH 63
Cdd:cd06433    4 TPTYNQAETLEETIDSVLsqtYPNiEYIVIDGGSTDGTVDIIKKYEDKITY 54
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 19-91 7.19e-03

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 36.69  E-value: 7.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492834064  19 AFNEAD-------RLRDCLTSLAFCDEIVVVDSGSTDATAAIASAHGAR-------VLHRAFdGYrsQKA-YC-VEQAHH 82
Cdd:cd04187    5 VYNEEEnlpelyeRLKAVLESLGYDYEIIFVDDGSTDRTLEILRELAARdprvkviRLSRNF-GQ--QAAlLAgLDHARG 81


                 ....*....
gi 492834064  83 DWVLCLDAD 91
Cdd:cd04187   82 DAVITMDAD 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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