NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|492859154|ref|WP_006012131|]
View 

MULTISPECIES: amino acid ABC transporter permease [Brucella]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11468467)

amino acid ABC transporter permease such as Rhizobium leguminosarum general L-amino acid transport system permease protein AapQ, which is part of a binding-protein-dependent transport system for L-amino acids and affects the uptake as well as efflux of these amino acids

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020|GO:0006865
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 9-397 0e+00

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 631.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154   9 RRQGSGGTSLLYDPRARGIFYQVVVFGAVIAGIYWIVGNTITNLQRANIASGFGFLYGRAGFDISQTLIQYNSDSTYGRA 88
Cdd:COG4597    8 PPPSPRLSSLLYDPRVRSILFQVLALALVVALVWYLVSNTLANLAARGIATGFGFLDRTAGFDISQSLIPYSPTDTYGRA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154  89 FLVGLVNTLYVAALGVVTASIIGFLVGIGRLSHNWLIRNICTVYVEVFRNIPPLLVIFFWYFGVLSVLPPVRQSYSMPLS 168
Cdd:COG4597   88 FLVGLLNTLLVAVLGIVLATILGFLVGIARLSSNWLVSKLATVYVEIFRNIPLLLQIFFWYFAVLEALPSPRQSLSLFDG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 169 TYINNRGFFMPSPVWGEGAWALPVALLIGILASFAVARWAKRRQMATGQPFHTIRVSAALIIGLPILALIATGFPVSFDV 248
Cdd:COG4597  168 VFLNNRGLYLPAPVFEPGFGWVLAALLAAIVAAFVLRRWARRRQEATGQRFPVWWISLALLVGLPLLAFLLLGAPLSLDY 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 249 PKLGTFNLTGGAQIKPEFLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLS 328
Cdd:COG4597  248 PELKGFNFRGGLTLSPEFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLT 327

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 329 SQYLNLIKNSSLAIAIGYPDLVAV-GGTILNQTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAKMALVER 397
Cdd:COG4597  328 SQYLNLTKNSSLAVAIGYPDLVSVfAGTTLNQTGQAIEIIAITMAVYLTISLLISLLMNWYNRRVALVER 397
 
Name Accession Description Interval E-value
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 9-397 0e+00

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 631.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154   9 RRQGSGGTSLLYDPRARGIFYQVVVFGAVIAGIYWIVGNTITNLQRANIASGFGFLYGRAGFDISQTLIQYNSDSTYGRA 88
Cdd:COG4597    8 PPPSPRLSSLLYDPRVRSILFQVLALALVVALVWYLVSNTLANLAARGIATGFGFLDRTAGFDISQSLIPYSPTDTYGRA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154  89 FLVGLVNTLYVAALGVVTASIIGFLVGIGRLSHNWLIRNICTVYVEVFRNIPPLLVIFFWYFGVLSVLPPVRQSYSMPLS 168
Cdd:COG4597   88 FLVGLLNTLLVAVLGIVLATILGFLVGIARLSSNWLVSKLATVYVEIFRNIPLLLQIFFWYFAVLEALPSPRQSLSLFDG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 169 TYINNRGFFMPSPVWGEGAWALPVALLIGILASFAVARWAKRRQMATGQPFHTIRVSAALIIGLPILALIATGFPVSFDV 248
Cdd:COG4597  168 VFLNNRGLYLPAPVFEPGFGWVLAALLAAIVAAFVLRRWARRRQEATGQRFPVWWISLALLVGLPLLAFLLLGAPLSLDY 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 249 PKLGTFNLTGGAQIKPEFLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLS 328
Cdd:COG4597  248 PELKGFNFRGGLTLSPEFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLT 327

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 329 SQYLNLIKNSSLAIAIGYPDLVAV-GGTILNQTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAKMALVER 397
Cdd:COG4597  328 SQYLNLTKNSSLAVAIGYPDLVSVfAGTTLNQTGQAIEIIAITMAVYLTISLLISLLMNWYNRRVALVER 397
PRK15100 PRK15100
cystine ABC transporter permease;
223-397 6.55e-17

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 79.02  E-value: 6.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 223 RVSAALIIGLPilaLIATGFPVSFDVPKLGTfnltggaQIKPeFLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYA 302
Cdd:PRK15100  56 RFYVSIFRGTP---LIAQLFMIYYGLPQFGI-------ELDP-IPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAAS 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 303 VGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIAIGYPDLVAVGGTIlnqTGQAVEVVAIWM---VIYLGISL 379
Cdd:PRK15100 125 IGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQAQLI---TSRTLEVFTMYLaasLIYWIMAT 201

                        170
                 ....*....|....*...
gi 492859154 380 IVSGLMNWFNAKMALVER 397
Cdd:PRK15100 202 VLSALQNRFENQLNRQER 219
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 264-392 3.10e-13

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 68.34  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154  264 PEFLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIA 343
Cdd:TIGR03003  84 PALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSA 163

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 492859154  344 IGYPDLVAVGGTILNQTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAKM 392
Cdd:TIGR03003 164 ITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 186-382 3.30e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 56.13  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 186 GAWALPVALLIGILASFAVARWAKRRQMAtgqpfhtIRVSAALIIGLPILALiatGFPVSFDVPKLGTFNLTGGAqikpe 265
Cdd:cd06261    8 ALIATLLALVLGLLLGIILARKRGKLDRL-------LRRIIDLLLSLPSLVL---GLLLVLLFGVLLGWGILPGL----- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 266 FLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIAIG 345
Cdd:cd06261   73 GLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG 152

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 492859154 346 YPDLVAVGGTILNQTGQAVEVVAIWMVIYLGISLIVS 382
Cdd:cd06261  153 GGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 266-392 2.24e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.60  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154  266 FLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIAIG 345
Cdd:pfam00528  52 ILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLG 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 492859154  346 -YPDLVAVGGTILN--QTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAKM 392
Cdd:pfam00528 132 sWPGLGLLLIEAILgyDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 9-397 0e+00

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 631.41  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154   9 RRQGSGGTSLLYDPRARGIFYQVVVFGAVIAGIYWIVGNTITNLQRANIASGFGFLYGRAGFDISQTLIQYNSDSTYGRA 88
Cdd:COG4597    8 PPPSPRLSSLLYDPRVRSILFQVLALALVVALVWYLVSNTLANLAARGIATGFGFLDRTAGFDISQSLIPYSPTDTYGRA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154  89 FLVGLVNTLYVAALGVVTASIIGFLVGIGRLSHNWLIRNICTVYVEVFRNIPPLLVIFFWYFGVLSVLPPVRQSYSMPLS 168
Cdd:COG4597   88 FLVGLLNTLLVAVLGIVLATILGFLVGIARLSSNWLVSKLATVYVEIFRNIPLLLQIFFWYFAVLEALPSPRQSLSLFDG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 169 TYINNRGFFMPSPVWGEGAWALPVALLIGILASFAVARWAKRRQMATGQPFHTIRVSAALIIGLPILALIATGFPVSFDV 248
Cdd:COG4597  168 VFLNNRGLYLPAPVFEPGFGWVLAALLAAIVAAFVLRRWARRRQEATGQRFPVWWISLALLVGLPLLAFLLLGAPLSLDY 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 249 PKLGTFNLTGGAQIKPEFLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLS 328
Cdd:COG4597  248 PELKGFNFRGGLTLSPEFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLT 327

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 329 SQYLNLIKNSSLAIAIGYPDLVAV-GGTILNQTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAKMALVER 397
Cdd:COG4597  328 SQYLNLTKNSSLAVAIGYPDLVSVfAGTTLNQTGQAIEIIAITMAVYLTISLLISLLMNWYNRRVALVER 397
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 84-393 1.19e-51

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 172.18  E-value: 1.19e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154  84 TYGRAFLVGLVNTLYVAALGVVTASIIGFLVGIGRLSHNWLIRNICTVYVEVFRNIPPLLVIFFWYFGvlsvlppvrqsy 163
Cdd:COG0765   10 DYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFG------------ 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 164 smplstyinnrgffmpspvwgegawaLPvalligilasfavarwakrrqmatgqpfhtirvsaalIIGLPIlaliatgfp 243
Cdd:COG0765   78 --------------------------LP-------------------------------------LLGIDL--------- 85

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 244 vsfdvpklgtfnltggaqikPEFLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRII 323
Cdd:COG0765   86 --------------------SPFVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRII 145

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 324 IPPLSSQYLNLIKNSSLAIAIGYPDLVAVGGTILNQTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAKMA 393
Cdd:COG0765  146 LPPLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLA 215
PRK15100 PRK15100
cystine ABC transporter permease;
223-397 6.55e-17

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 79.02  E-value: 6.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 223 RVSAALIIGLPilaLIATGFPVSFDVPKLGTfnltggaQIKPeFLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYA 302
Cdd:PRK15100  56 RFYVSIFRGTP---LIAQLFMIYYGLPQFGI-------ELDP-IPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAAS 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 303 VGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIAIGYPDLVAVGGTIlnqTGQAVEVVAIWM---VIYLGISL 379
Cdd:PRK15100 125 IGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQAQLI---TSRTLEVFTMYLaasLIYWIMAT 201

                        170
                 ....*....|....*...
gi 492859154 380 IVSGLMNWFNAKMALVER 397
Cdd:PRK15100 202 VLSALQNRFENQLNRQER 219
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 88-392 3.90e-16

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 76.63  E-value: 3.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154  88 AFLVGLVNTLYVAALGVVTASIIGFLVGIGRLSHNWLIRNICTVYVEVFRNIPPLLVIFFWYFGVLSVLPPVRQsysmpl 167
Cdd:PRK09494  14 LLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAFNDLRI------ 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 168 styinnrgffmpspvwgegawalpvalligilasfavarwakrrqmatgQPFhtirvSAALIiglpilaliatgfpvsfd 247
Cdd:PRK09494  88 -------------------------------------------------DPF-----TAAVV------------------ 95

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 248 vpklgTFNLTGGAqikpeflalflalsfytasFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPL 327
Cdd:PRK09494  96 -----TIMINSGA-------------------YIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPL 151

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492859154 328 SSQYLNLIKNSSLAIAIGYPDLVAVGGTILNQTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAKM 392
Cdd:PRK09494 152 GNQWIISIKDTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERRM 216
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
271-391 6.84e-16

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 76.02  E-value: 6.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 271 LALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIAIGYPDLV 350
Cdd:PRK15107 102 VAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLADFF 181

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 492859154 351 AVGGTILNQTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAK 391
Cdd:PRK15107 182 RTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
193-397 8.53e-15

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 73.17  E-value: 8.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 193 ALLIGILASFAVARWAKRRQMATGQPFHTIrvsAALIIGLP--------------ILALIATGFPVSFDVPKLGTFNLTG 258
Cdd:PRK11123  21 ALIVGLALAMLFAVWESAKWRPVAWPGTAL---VTLLRGLPeilvvlfiyfgssqLLLTLSDGFTLNLGFVQIPVQMDIE 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 259 GAQIKPeFLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNS 338
Cdd:PRK11123  98 NFEVSP-FLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVLLKDT 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 492859154 339 SLAIAIGYPDLVAVGGTILNQTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAKMALVER 397
Cdd:PRK11123 177 ALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELRATRFER 235
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 264-392 3.10e-13

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 68.34  E-value: 3.10e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154  264 PEFLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIA 343
Cdd:TIGR03003  84 PALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSA 163

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 492859154  344 IGYPDLVAVGGTILNQTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAKM 392
Cdd:TIGR03003 164 ITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 88-151 5.23e-13

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 64.48  E-value: 5.23e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 492859154   88 AFLVGLVNTLYVAALGVVTASIIGFLVGIGRLSHNWLIRNICTVYVEVFRNIPPLLVIFFWYFG 151
Cdd:TIGR01726   4 FLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFG 67
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 186-382 3.30e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 56.13  E-value: 3.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 186 GAWALPVALLIGILASFAVARWAKRRQMAtgqpfhtIRVSAALIIGLPILALiatGFPVSFDVPKLGTFNLTGGAqikpe 265
Cdd:cd06261    8 ALIATLLALVLGLLLGIILARKRGKLDRL-------LRRIIDLLLSLPSLVL---GLLLVLLFGVLLGWGILPGL----- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 266 FLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIAIG 345
Cdd:cd06261   73 GLPALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG 152

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 492859154 346 YPDLVAVGGTILNQTGQAVEVVAIWMVIYLGISLIVS 382
Cdd:cd06261  153 GGEAPGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
PRK15069 PRK15069
histidine ABC transporter permease HisM;
267-384 3.79e-07

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 50.82  E-value: 3.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 267 LALFLALSFYTASFIAETVRAgvlgVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIAIGY 346
Cdd:PRK15069 107 LAFTLNTCAYTTEIFAGAIRS----VPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTATV 182

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 492859154 347 PDLVAVGGTILNQTGQAVEVVAIWMVIYLGISLIVSGL 384
Cdd:PRK15069 183 PDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISL 220
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
271-389 2.53e-06

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 48.25  E-value: 2.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 271 LALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIAIGYPDLV 350
Cdd:PRK15135  98 ITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSLLGLEDVV 177

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 492859154 351 AVGGTILNQTGQAVEVVAIWMVIYLGISLIVSGLMNWFN 389
Cdd:PRK15135 178 KATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLE 216
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 266-392 2.24e-05

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 44.60  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154  266 FLALFLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRLIIVPQALRIIIPPLSSQYLNLIKNSSLAIAIG 345
Cdd:pfam00528  52 ILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLG 131

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 492859154  346 -YPDLVAVGGTILN--QTGQAVEVVAIWMVIYLGISLIVSGLMNWFNAKM 392
Cdd:pfam00528 132 sWPGLGLLLIEAILgyDYPEIQGPVLAAALILLLLNLLVDILQRLLDPRV 181
artM PRK11122
arginine ABC transporter permease ArtM;
264-397 8.48e-05

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 43.41  E-value: 8.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492859154 264 PEFLALfLALSFYTASFIAETVRAGVLGVSKGQTEAAYAVGLRSGQTMRlIIVPQALRIIIPPLSSQYLNLIKNSSLAIA 343
Cdd:PRK11122  90 PWLCAM-LALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVFKSTSLAYT 167

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 492859154 344 IGYPDLVAVGGTILNQTGQAVeVVAIWMVIYLGISLIVSGLMNWFNAKMALVER 397
Cdd:PRK11122 168 ITLMDVMGYSQLLYGRTYDVM-VFGAAGIIYLVVNGLLTLLMRLIERKALAFER 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH