Galactofuranosyltransferase-2, domain 3; This entry represents the third domain of GlfT2 ...
476-672
6.14e-131
Galactofuranosyltransferase-2, domain 3; This entry represents the third domain of GlfT2 (Rv3808c), a polymerizing galactofuranosyltransferase that synthesizes the galactan portion of the peptidoglycan complex of the mycobacteria cell wall. It consists of eight alpha-helices, five of which immediately follow the glycosyltransferase (GT) domain and form the central portion of domain 3. Three helices at the C terminus of the polypeptide chain wrap around these core helices to complete the domain. The first helix in domain 3 anchors loop 1 and is conserved in many GT-A proteins. The flanking domains and many hydrophobic residues found at the interface between domains 2 and 3 of this protein are conserved among many proteins of mycobacteria, related Actinobacteria and more distantly related species, suggesting conserved structure structure and function relationships. The alpha2- and alpha6-helices from domain 3 and alpha1 from domain 4 contribute with a patch of exposed hydrophobic residues which probably generate a binding site for the hydrophobic acyl chains of membrane phospholipids. These surface-exposed hydrophobic residues may also contribute to the specificity and affinity binding of UDP donors.
:
Pssm-ID: 437152 Cd Length: 197 Bit Score: 383.82 E-value: 6.14e-131
Galactofuranosyltransferase 2 N-terminal; This is the N-terminal beta-barrel domain found in ...
29-168
1.07e-97
Galactofuranosyltransferase 2 N-terminal; This is the N-terminal beta-barrel domain found in the polymerizing galactofuranosyltransferase GlfT2 (Rv3808c). This enzyme synthesizes the bulk of the galactan portion of the mycolyl-arabinogalactan complex, which is the largest component of the mycobacterial cell wall such as in Mycobacterium tuberculosis. The N-terminal domain contains two short helices preceding a 10-stranded beta-sandwich with jelly roll topology.
:
Pssm-ID: 436195 Cd Length: 140 Bit Score: 296.10 E-value: 1.07e-97
Galactofuranosyltransferase-2, domain 3; This entry represents the third domain of GlfT2 ...
476-672
6.14e-131
Galactofuranosyltransferase-2, domain 3; This entry represents the third domain of GlfT2 (Rv3808c), a polymerizing galactofuranosyltransferase that synthesizes the galactan portion of the peptidoglycan complex of the mycobacteria cell wall. It consists of eight alpha-helices, five of which immediately follow the glycosyltransferase (GT) domain and form the central portion of domain 3. Three helices at the C terminus of the polypeptide chain wrap around these core helices to complete the domain. The first helix in domain 3 anchors loop 1 and is conserved in many GT-A proteins. The flanking domains and many hydrophobic residues found at the interface between domains 2 and 3 of this protein are conserved among many proteins of mycobacteria, related Actinobacteria and more distantly related species, suggesting conserved structure structure and function relationships. The alpha2- and alpha6-helices from domain 3 and alpha1 from domain 4 contribute with a patch of exposed hydrophobic residues which probably generate a binding site for the hydrophobic acyl chains of membrane phospholipids. These surface-exposed hydrophobic residues may also contribute to the specificity and affinity binding of UDP donors.
Pssm-ID: 437152 Cd Length: 197 Bit Score: 383.82 E-value: 6.14e-131
Galactofuranosyltransferase 2 N-terminal; This is the N-terminal beta-barrel domain found in ...
29-168
1.07e-97
Galactofuranosyltransferase 2 N-terminal; This is the N-terminal beta-barrel domain found in the polymerizing galactofuranosyltransferase GlfT2 (Rv3808c). This enzyme synthesizes the bulk of the galactan portion of the mycolyl-arabinogalactan complex, which is the largest component of the mycobacterial cell wall such as in Mycobacterium tuberculosis. The N-terminal domain contains two short helices preceding a 10-stranded beta-sandwich with jelly roll topology.
Pssm-ID: 436195 Cd Length: 140 Bit Score: 296.10 E-value: 1.07e-97
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
187-461
3.24e-18
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.
Pssm-ID: 433372 [Multi-domain] Cd Length: 230 Bit Score: 84.34 E-value: 3.24e-18
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
195-464
2.71e-10
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.
Pssm-ID: 133028 [Multi-domain] Cd Length: 202 Bit Score: 60.34 E-value: 2.71e-10
Galactofuranosyltransferase-2, domain 3; This entry represents the third domain of GlfT2 ...
476-672
6.14e-131
Galactofuranosyltransferase-2, domain 3; This entry represents the third domain of GlfT2 (Rv3808c), a polymerizing galactofuranosyltransferase that synthesizes the galactan portion of the peptidoglycan complex of the mycobacteria cell wall. It consists of eight alpha-helices, five of which immediately follow the glycosyltransferase (GT) domain and form the central portion of domain 3. Three helices at the C terminus of the polypeptide chain wrap around these core helices to complete the domain. The first helix in domain 3 anchors loop 1 and is conserved in many GT-A proteins. The flanking domains and many hydrophobic residues found at the interface between domains 2 and 3 of this protein are conserved among many proteins of mycobacteria, related Actinobacteria and more distantly related species, suggesting conserved structure structure and function relationships. The alpha2- and alpha6-helices from domain 3 and alpha1 from domain 4 contribute with a patch of exposed hydrophobic residues which probably generate a binding site for the hydrophobic acyl chains of membrane phospholipids. These surface-exposed hydrophobic residues may also contribute to the specificity and affinity binding of UDP donors.
Pssm-ID: 437152 Cd Length: 197 Bit Score: 383.82 E-value: 6.14e-131
Galactofuranosyltransferase 2 N-terminal; This is the N-terminal beta-barrel domain found in ...
29-168
1.07e-97
Galactofuranosyltransferase 2 N-terminal; This is the N-terminal beta-barrel domain found in the polymerizing galactofuranosyltransferase GlfT2 (Rv3808c). This enzyme synthesizes the bulk of the galactan portion of the mycolyl-arabinogalactan complex, which is the largest component of the mycobacterial cell wall such as in Mycobacterium tuberculosis. The N-terminal domain contains two short helices preceding a 10-stranded beta-sandwich with jelly roll topology.
Pssm-ID: 436195 Cd Length: 140 Bit Score: 296.10 E-value: 1.07e-97
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
187-461
3.24e-18
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.
Pssm-ID: 433372 [Multi-domain] Cd Length: 230 Bit Score: 84.34 E-value: 3.24e-18
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
195-464
2.71e-10
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.
Pssm-ID: 133028 [Multi-domain] Cd Length: 202 Bit Score: 60.34 E-value: 2.71e-10
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
190-332
3.37e-04
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
Pssm-ID: 425738 [Multi-domain] Cd Length: 166 Bit Score: 41.61 E-value: 3.37e-04
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
191-321
5.50e-04
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.
Pssm-ID: 132997 [Multi-domain] Cd Length: 156 Bit Score: 40.95 E-value: 5.50e-04
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
191-345
3.03e-03
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.
Pssm-ID: 133029 [Multi-domain] Cd Length: 166 Bit Score: 39.08 E-value: 3.03e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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