|
Name |
Accession |
Description |
Interval |
E-value |
| RpiR |
COG1737 |
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ... |
1-282 |
3.30e-65 |
|
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];
Pssm-ID: 441343 [Multi-domain] Cd Length: 286 Bit Score: 205.93 E-value: 3.30e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 1 MSKVADIITRLHVVVQEGSKSDRRLAGLVLADPHYASKAAISEIAARAGVSEPTVTRFCRALGCDGVRDFKFFLAQALAI 80
Cdd:COG1737 1 MMSAMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 81 GGQYLT-AEIPARDVRESRIATAVTDAAIAAIQRAGDGVDMGVLMKVAERLAAGGPVLCLGSGGmSSMLATEMENRLFRL 159
Cdd:COG1737 81 GLSSYErLRRLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGA-SAPVAEDLAYKLLRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 160 GIPVNA-QVDGQLQRMYAAVTTHETTVLAFSVSGFVRSVVEAVLVARQYGAETVAITA-AGSDLARAADMLIPFQPNEDG 237
Cdd:COG1737 160 GKNVVLlDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDsPLSPLAKLADVVLYVPSEEPT 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 493166133 238 NIYKPTSARYGLLAILDMIATAAAEARGPKVLESLRRIKHSLNTL 282
Cdd:COG1737 240 LRSSAFSSRVAQLALIDALAAAVAQRDGDKARERLERTEALLSEL 284
|
|
| PRK11302 |
PRK11302 |
DNA-binding transcriptional regulator HexR; Provisional |
19-280 |
8.76e-54 |
|
DNA-binding transcriptional regulator HexR; Provisional
Pssm-ID: 183082 [Multi-domain] Cd Length: 284 Bit Score: 176.34 E-value: 8.76e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 19 SKSDRRLAGLVLADPHYASKAAISEIAARAGVSEPTVTRFCRALGCDGVRDFKFFLAQALAIGGQYLTaeipaRDVRESR 98
Cdd:PRK11302 15 SKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPYVN-----RNVEEDD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 99 IATAVTD----AAIAAIQRAGDGVDMGVLMKVAERLAAGGPVLCLGSGGmSSMLATEMENRLFRLGIPVNAQVDGQLQRM 174
Cdd:PRK11302 90 SVEAYTGkifeSAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGA-SAAVAHDAQNKFFRFNVPVVYFDDIVMQRM 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 175 YAAVTTHETTVLAFSVSGFVRSVVEAVLVARQYGAETVAITAAGSDLARAADMLIPFQPNEDGNIYKPTSARYGLLAILD 254
Cdd:PRK11302 169 SCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITSAGSPLAREATLALTLDVPEDTDIYMPMVSRIAQLTVID 248
|
250 260
....*....|....*....|....*.
gi 493166133 255 MIATAAAEARGPKVLESLRRIKHSLN 280
Cdd:PRK11302 249 VLATGFTLRRGAKFRDNLKRVKEALK 274
|
|
| SIS_RpiR |
cd05013 |
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ... |
123-259 |
1.73e-24 |
|
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.
Pssm-ID: 240144 [Multi-domain] Cd Length: 139 Bit Score: 95.76 E-value: 1.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 123 LMKVAERLAAGGPVLCLGSGGmSSMLATEMENRLFRLGIPVNAQVDGQLQRMYAAVTTHETTVLAFSVSGFVRSVVEAVL 202
Cdd:cd05013 3 LEKAVDLLAKARRIYIFGVGS-SGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 493166133 203 VARQYGAETVAITAAG-SDLARAADMLIPFQPNEDGNIYKPTSARYGLLAILDMIATA 259
Cdd:cd05013 82 IAKERGAKVIAITDSAnSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
|
|
| HTH_6 |
pfam01418 |
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ... |
16-79 |
2.72e-17 |
|
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.
Pssm-ID: 334531 [Multi-domain] Cd Length: 77 Bit Score: 74.67 E-value: 2.72e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493166133 16 QEGSKSDRRLAGLVLADPHYASKAAISEIAARAGVSEPTVTRFCRALGCDGVRDFKFFLAQALA 79
Cdd:pfam01418 12 SKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGELA 75
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RpiR |
COG1737 |
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ... |
1-282 |
3.30e-65 |
|
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];
Pssm-ID: 441343 [Multi-domain] Cd Length: 286 Bit Score: 205.93 E-value: 3.30e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 1 MSKVADIITRLHVVVQEGSKSDRRLAGLVLADPHYASKAAISEIAARAGVSEPTVTRFCRALGCDGVRDFKFFLAQALAI 80
Cdd:COG1737 1 MMSAMSLLERIRARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 81 GGQYLT-AEIPARDVRESRIATAVTDAAIAAIQRAGDGVDMGVLMKVAERLAAGGPVLCLGSGGmSSMLATEMENRLFRL 159
Cdd:COG1737 81 GLSSYErLRRLSPDDSLEDILAKVLEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGA-SAPVAEDLAYKLLRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 160 GIPVNA-QVDGQLQRMYAAVTTHETTVLAFSVSGFVRSVVEAVLVARQYGAETVAITA-AGSDLARAADMLIPFQPNEDG 237
Cdd:COG1737 160 GKNVVLlDGDGHLQAESAALLGPGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDsPLSPLAKLADVVLYVPSEEPT 239
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 493166133 238 NIYKPTSARYGLLAILDMIATAAAEARGPKVLESLRRIKHSLNTL 282
Cdd:COG1737 240 LRSSAFSSRVAQLALIDALAAAVAQRDGDKARERLERTEALLSEL 284
|
|
| PRK11302 |
PRK11302 |
DNA-binding transcriptional regulator HexR; Provisional |
19-280 |
8.76e-54 |
|
DNA-binding transcriptional regulator HexR; Provisional
Pssm-ID: 183082 [Multi-domain] Cd Length: 284 Bit Score: 176.34 E-value: 8.76e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 19 SKSDRRLAGLVLADPHYASKAAISEIAARAGVSEPTVTRFCRALGCDGVRDFKFFLAQALAIGGQYLTaeipaRDVRESR 98
Cdd:PRK11302 15 SKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLANGTPYVN-----RNVEEDD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 99 IATAVTD----AAIAAIQRAGDGVDMGVLMKVAERLAAGGPVLCLGSGGmSSMLATEMENRLFRLGIPVNAQVDGQLQRM 174
Cdd:PRK11302 90 SVEAYTGkifeSAMASLDHARQSLDPSAINRAVDLLTQAKKISFFGLGA-SAAVAHDAQNKFFRFNVPVVYFDDIVMQRM 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 175 YAAVTTHETTVLAFSVSGFVRSVVEAVLVARQYGAETVAITAAGSDLARAADMLIPFQPNEDGNIYKPTSARYGLLAILD 254
Cdd:PRK11302 169 SCMNSSDGDVVVLISHTGRTKSLVELAQLARENGATVIAITSAGSPLAREATLALTLDVPEDTDIYMPMVSRIAQLTVID 248
|
250 260
....*....|....*....|....*.
gi 493166133 255 MIATAAAEARGPKVLESLRRIKHSLN 280
Cdd:PRK11302 249 VLATGFTLRRGAKFRDNLKRVKEALK 274
|
|
| PRK14101 |
PRK14101 |
bifunctional transcriptional regulator/glucokinase; |
19-264 |
2.73e-30 |
|
bifunctional transcriptional regulator/glucokinase;
Pssm-ID: 184507 [Multi-domain] Cd Length: 638 Bit Score: 120.02 E-value: 2.73e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 19 SKSDRRLAGLVLADPHYASKAAISEIAARAGVSEPTVTRFCRALGCDGVRDFKFFLAQALAIGGQYLTAEIPARDVRESR 98
Cdd:PRK14101 355 TPAERRVADLALNHPRSIINDPIVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGLTGTIPMSHSQVHLGDTATDF 434
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 99 IATaVTDAAIAAIQRAGDGVDMGVLMKVAERLAAGGPVLCLGSGGmSSMLATEMENRLFRLGIPVNAQVDGQLQRMYAAV 178
Cdd:PRK14101 435 GAK-VLDNTVSAILQLREHLNFEHVEQAIDILNNARRIEFYGLGN-SNIVAQDAHYKFFRFGIPTIAYGDLYMQAASAAL 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 179 TTHETTVLAFSVSGFVRSVVEAVLVARQYGAETVAITAAGSDLARAADMLIPFQPNEDGNIYKPTSARYGLLAILDMIAT 258
Cdd:PRK14101 513 LGKGDVIVAVSKSGRAPELLRVLDVAMQAGAKVIAITSSNTPLAKRATVALETDHIEMRESQLSMISRILHLVMIDILAV 592
|
....*.
gi 493166133 259 AAAEAR 264
Cdd:PRK14101 593 GVAIRR 598
|
|
| SIS_RpiR |
cd05013 |
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ... |
123-259 |
1.73e-24 |
|
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.
Pssm-ID: 240144 [Multi-domain] Cd Length: 139 Bit Score: 95.76 E-value: 1.73e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 123 LMKVAERLAAGGPVLCLGSGGmSSMLATEMENRLFRLGIPVNAQVDGQLQRMYAAVTTHETTVLAFSVSGFVRSVVEAVL 202
Cdd:cd05013 3 LEKAVDLLAKARRIYIFGVGS-SGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGDVVIAISFSGETKETVEAAE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 493166133 203 VARQYGAETVAITAAG-SDLARAADMLIPFQPNEDGNIYKPTSARYGLLAILDMIATA 259
Cdd:cd05013 82 IAKERGAKVIAITDSAnSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALFLA 139
|
|
| PRK11337 |
PRK11337 |
MurR/RpiR family transcriptional regulator; |
22-262 |
3.16e-24 |
|
MurR/RpiR family transcriptional regulator;
Pssm-ID: 183089 [Multi-domain] Cd Length: 292 Bit Score: 99.06 E-value: 3.16e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 22 DRRLAGLVLADPHYASKAAISEIAARAGVSEPTVTRFCRALGCDGVRDFKFFLAQALAIGGQYLTAEIPARDVRESRIAT 101
Cdd:PRK11337 30 ESRVVEWLLKPGDLSEATALKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALEDYFSQSEQVLHSELSFDDAPQDVVNK 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 102 aVTDAAIAAIQRAGDGVDMGVLMKVAERLAAGGPVLCLGSGGmSSMLATEMENRLFRLGIPVNAQVDGQLQRMYAAVTTH 181
Cdd:PRK11337 110 -VFNTSLQAIEETQSILDVDEFHRAARFFYQARQRDLYGAGG-SAAIARDVQHKFLRIGVRCQAYDDAHIMLMSAALLQE 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 182 ETTVLAFSVSGFVRSVVEAVLVARQYGAETVAIT-AAGSDLARAADMLIPFQPNEDGNIYKPTSARYGLLAILDMIATAA 260
Cdd:PRK11337 188 GDVVLVVSHSGRTSDVIEAVELAKKNGAKIICITnSYHSPIAKLADYVICSTAQGSPLLGENAAARIAQLNILDAFFVSV 267
|
..
gi 493166133 261 AE 262
Cdd:PRK11337 268 AQ 269
|
|
| HTH_6 |
pfam01418 |
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ... |
16-79 |
2.72e-17 |
|
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.
Pssm-ID: 334531 [Multi-domain] Cd Length: 77 Bit Score: 74.67 E-value: 2.72e-17
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493166133 16 QEGSKSDRRLAGLVLADPHYASKAAISEIAARAGVSEPTVTRFCRALGCDGVRDFKFFLAQALA 79
Cdd:pfam01418 12 SKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGELA 75
|
|
| PRK15482 |
PRK15482 |
HTH-type transcriptional regulator MurR; |
8-278 |
4.76e-12 |
|
HTH-type transcriptional regulator MurR;
Pssm-ID: 185379 [Multi-domain] Cd Length: 285 Bit Score: 65.10 E-value: 4.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 8 ITRLHVVVQEGSKSDRRLAGLVLADPHYASKAAISEIAARAGVSEPTVTRFCRALGCDGVRDFKFFLAQALAIG------ 81
Cdd:PRK15482 4 LTKIRNAESEFTENEQKIADFLRANVSELKSVSSRKMAKQLGISQSSIVKFAQKLGAQGFTELRMALIGEYSASrektna 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 82 -GQYLTAEIPARDVRESrIATAVTDAAIAAIQRAGDGVDMGVLMKVAERLAAGGPVLCLGSGGmSSMLATEMENRLFRLG 160
Cdd:PRK15482 84 tALHLHSSITSDDSLEV-IARKLNREKELALEQTCALFDYARLQKIIEVISKAPFIQITGLGG-SALVGRDLSFKLMKIG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 161 IPVNAQVDGQLQRMYAAVTTHETTVLAFSVSGFVRSVVEAVLVARQYGAETVAITA-AGSDLARAADMLIPFQPNEDGNI 239
Cdd:PRK15482 162 YRVACEADTHVQATVSQALKKGDVQIAISYSGSKKEIVLCAEAARKQGATVIAITSlADSPLRRLAHFTLDTVSGETEWR 241
|
250 260 270
....*....|....*....|....*....|....*....
gi 493166133 240 YKPTSARYGLLAILDMIATAAAEARGpkvLESLRRIKHS 278
Cdd:PRK15482 242 SSSMSTRTAQNSVTDLLFVGLVQLND---VESLKMIQRS 277
|
|
| PRK11557 |
PRK11557 |
MurR/RpiR family transcriptional regulator; |
19-215 |
3.24e-08 |
|
MurR/RpiR family transcriptional regulator;
Pssm-ID: 183195 [Multi-domain] Cd Length: 278 Bit Score: 53.62 E-value: 3.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 19 SKSDRRLAGLVLADPHYASKAAISEIAARAGVSEPTVTRFCRALGCDGVRDFKFFLAQALAIGGQYLTAEI--------P 90
Cdd:PRK11557 11 AQSDRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEALASQPEPPSVPVhnqirgddP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 91 ARDVRESRIATAVtdaaiAAIQRAGDGVDMGVLMKVAERLAAGGPVLCLGSGGmSSMLATEMENRLFRLGIPVNAQVDGQ 170
Cdd:PRK11557 91 LRLVGEKLIKENT-----AAMRATLDVNSEEKLHECVTMLRSARRIILTGIGA-SGLVAQNFAWKLMKIGINAVAERDMH 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 493166133 171 LQRMYAAVTTHETTVLAFSVSGFVRSVVEAVLVARQYGAETVAIT 215
Cdd:PRK11557 165 ALLATVQALSPDDLLLAISYSGERRELNLAADEALRVGAKVLAIT 209
|
|
| SIS_GmhA |
cd05006 |
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose ... |
97-229 |
1.35e-05 |
|
Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of gram-negative bacteria inner core lipopolysaccharide precursor, L-glycero-D-mannoheptose (Gmh).
Pssm-ID: 240139 [Multi-domain] Cd Length: 177 Bit Score: 44.81 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 97 SRIATAVTDAAIAAIQRAGDgvdmgvlmKVAERLAAGGPVLCLGSGGMSSM---LATEMENR--LFRLGIPVNA------ 165
Cdd:cd05006 5 IQLKEALLELLAEAIEQAAQ--------LLAEALLNGGKILICGNGGSAADaqhFAAELVKRfeKERPGLPAIAlttdts 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 166 -----------------QVDGQLQRmyaavtthETTVLAFSVSGFVRSVVEAVLVARQYGAETVAITAA-GSDLARAADM 227
Cdd:cd05006 77 iltaiandygyeevfsrQVEALGQP--------GDVLIGISTSGNSPNVLKALEAAKERGMKTIALTGRdGGKLLELADI 148
|
..
gi 493166133 228 LI 229
Cdd:cd05006 149 EI 150
|
|
| SIS_PHI |
cd05005 |
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ... |
104-230 |
2.59e-05 |
|
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.
Pssm-ID: 240138 [Multi-domain] Cd Length: 179 Bit Score: 43.72 E-value: 2.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 104 TDAAIAAIQRAGDGVDMGVLMKVAERLAAGGPVLCLG---SGGMSSMLAteMenRLFRLGIPVNaqVDGqlqrmyaavtt 180
Cdd:cd05005 4 LSLILEEIENVADKIDEEELDKLISAILNAKRIFVYGagrSGLVAKAFA--M--RLMHLGLNVY--VVG----------- 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493166133 181 hETT---------VLAFSVSGFVRSVVEAVLVARQYGAETVAITA-AGSDLARAAD--MLIP 230
Cdd:cd05005 67 -ETTtpaigpgdlLIAISGSGETSSVVNAAEKAKKAGAKVVLITSnPDSPLAKLADvvVVIP 127
|
|
| AgaS |
COG2222 |
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ... |
109-230 |
2.87e-05 |
|
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441824 [Multi-domain] Cd Length: 336 Bit Score: 44.89 E-value: 2.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 109 AAIQRAGDGVDmGVLMKVAERLAAGGP--VLCLGSGgmSSMLATEMENRLFR--LGIPVNAQVDGQLQRMYAAVTTHETT 184
Cdd:COG2222 9 EAWRRALAALA-AAIAALLARLRAKPPrrVVLVGAG--SSDHAAQAAAYLLErlLGIPVAALAPSELVVYPAYLKLEGTL 85
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 493166133 185 VLAFSVSGfvRS--VVEAVLVARQYGAETVAIT-AAGSDLARAADMLIP 230
Cdd:COG2222 86 VVAISRSG--NSpeVVAALELAKARGARTLAITnNPDSPLAEAADRVLP 132
|
|
| SIS |
pfam01380 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
143-259 |
3.41e-05 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.
Pssm-ID: 426230 [Multi-domain] Cd Length: 131 Bit Score: 42.67 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 143 GMSSMLATEMENRLFRLG-IPVNAQVDGQLQRMYAAVTTHETTVLAFSVSGFVRSVVEAVLVARQYGAETVAITA-AGSD 220
Cdd:pfam01380 14 GTSYAIALELALKFEEIGyKVVEVELASELRHGVLALVDEDDLVIAISYSGETKDLLAAAELAKARGAKIIAITDsPGSP 93
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 493166133 221 LARAAD--MLIPFQPNEdgnIYKPTSARYGLLAILDMIATA 259
Cdd:pfam01380 94 LAREADhvLYINAGPET---GVASTKSITAQLAALDALAVA 131
|
|
| SIS_GlmS_GlmD_1 |
cd05008 |
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ... |
159-230 |
7.62e-05 |
|
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.
Pssm-ID: 240141 [Multi-domain] Cd Length: 126 Bit Score: 41.71 E-value: 7.62e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493166133 159 LGIPVNAQVDGQLqRMYAAVTTHETTVLAFSVSGFVRSVVEAVLVARQYGAETVAIT-AAGSDLARAADMLIP 230
Cdd:cd05008 25 AGIPVEVEAASEF-RYRRPLLDEDTLVIAISQSGETADTLAALRLAKEKGAKTVAITnVVGSTLAREADYVLY 96
|
|
| SIS_1 |
cd05710 |
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ... |
180-237 |
1.50e-03 |
|
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 240214 [Multi-domain] Cd Length: 120 Bit Score: 37.56 E-value: 1.50e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 493166133 180 THETTVLAFSVSGFVRSVVEAVLVARQYGAETVAIT-AAGSDLARAADMLIPFQPNEDG 237
Cdd:cd05710 46 TEKSVVILASHSGNTKETVAAAKFAKEKGATVIGLTdDEDSPLAKLADYVIVYGFEIDA 104
|
|
| SIS_2 |
pfam13580 |
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ... |
98-215 |
6.98e-03 |
|
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.
Pssm-ID: 433326 [Multi-domain] Cd Length: 138 Bit Score: 36.03 E-value: 6.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 98 RIATAVTDAAIAAIQRAGDgvdmgvlmKVAERLAAGGPVLCLGSGGmSSMLATEMENRlFRLGIPVNAQVDGQL---QRM 174
Cdd:pfam13580 8 ALLERVVETQADAIEKAAD--------LIAASLANGGKVYAFGTGH-SAAPAEELFAR-AGGLAGFEPILLPALalhTDA 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 493166133 175 YAAVTTH-------------------ETTVLAFSVSGFVRSVVEAVLVARQYGAETVAIT 215
Cdd:pfam13580 78 SATISTAlerdegyarqilalypgrpGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
|
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| |
