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Conserved domains on  [gi|493201746|ref|WP_006190284|]
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nickel transporter permease [Staphylococcus aureus]

Protein Classification

ABC transporter permease( domain architecture ID 11439449)

ABC transporter permease is the transmembrane (TM) subunit in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which generally binds a type 2 PBP; similar to the permease subunit of ABC-type dipeptide/oligopeptide/nickel transport systems

Gene Ontology:  GO:0140359|GO:0042626
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 28-265 4.29e-88

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


:

Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 263.13  E-value: 4.29e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  28 FVSSENATKVNLSQTFEPISWLHLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLR 107
Cdd:COG1173   37 LLAPYDPTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 108 FIDVGLSIPEFIIMIALASFFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKII 187
Cdd:COG1173  117 LVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVL 196

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493201746 188 PAIIVLMVVDFGKIILYISSLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:COG1173  197 PPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPWLALFPGLAIVLTVLAFNLLGDGLRDAL 274
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 28-265 4.29e-88

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 263.13  E-value: 4.29e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  28 FVSSENATKVNLSQTFEPISWLHLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLR 107
Cdd:COG1173   37 LLAPYDPTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 108 FIDVGLSIPEFIIMIALASFFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKII 187
Cdd:COG1173  117 LVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVL 196

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493201746 188 PAIIVLMVVDFGKIILYISSLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:COG1173  197 PPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPWLALFPGLAIVLTVLAFNLLGDGLRDAL 274
nickel_nikC TIGR02790
nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of ...
 28-265 5.98e-69

nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131837 [Multi-domain]  Cd Length: 258  Bit Score: 213.79  E-value: 5.98e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746   28 FVSSENATKVNLSQTFEPISWLHLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLR 107
Cdd:TIGR02790  20 WIAPHDPLAQNLPMRLLGPSMEYWLGTDHLGRCIFSRLIFGARVSLGSALLVLGLVLTIGLLIGGLAGYIGGRVDEAIMR 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  108 FIDVGLSIPEFIIMIALASFFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKII 187
Cdd:TIGR02790 100 VCDVFLSFPTIILSLAIVGILGPGLENVIIAIVLVHWAWYARMVRGMVVSLKQREFVLAARTSGASHWQIIRRHILPNIL 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493201746  188 PAIIVLMVVDFGKIILYISSLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:TIGR02790 180 SPIIVLATLDIGHVILHIAGLSFLGLGIQPPTPEWGAMLSEAKQYIWTQPLLMIYPGLAILISVMAFNLLGDALRDHL 257
nikC PRK10417
nickel transporter permease NikC; Provisional
 37-265 4.05e-62

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 196.81  E-value: 4.05e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  37 VNLSQTFEPISWLHLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLRFIDVGLSIP 116
Cdd:PRK10417  34 IDLPSRLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMACLLLVLALGLVIGGSAGLLGGRVDQATMRVADMFMTFP 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 117 EFIIMIALASFFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVV 196
Cdd:PRK10417 114 TSILAFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLRQREFVLAARLSGAGHVRVFIDHLLPAVIPQLLVLATL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493201746 197 DFGKIILYISSLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:PRK10417 194 DIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQYIWTQPLLMFWPGLALFISVMAFNLLGDALRDHL 262
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 69-253 1.95e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.09  E-value: 1.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  69 ARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLRFIDVGLSIPEFIIMIALASFF--------QPSLWNLVISIT 140
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFgvllgwgiLPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 141 VIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVVDFGKIILYISSLSFIGLGAqPPTP 220
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE-APGP 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 493201746 221 EWGAMLQQGRDFisshPIMLIAPASVIAITILI 253
Cdd:cd06261  160 GTGLLLIFAILF----PGDLGVAAAVALILLLL 188
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 87-265 2.65e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 66.55  E-value: 2.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746   87 GVTLGLFAG-YKKGWIERLVLRFIDVGLSIPEFIIMIALASFFQPSLWNL----VISITVIKWMNYTRLTRSIVNSEMNK 161
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHgilpAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  162 PYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVVDFGKIILYISSLSFI----GLGAQPPTPEWGAMLQqgrdfisshp 237
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYP---------- 150

                         170       180
                  ....*....|....*....|....*...
gi 493201746  238 iMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:pfam00528 151 -EIQGPVLAAALILLLLNLLVDILQRLL 177
 
Name Accession Description Interval E-value
DppC COG1173
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 28-265 4.29e-88

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440786 [Multi-domain]  Cd Length: 275  Bit Score: 263.13  E-value: 4.29e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  28 FVSSENATKVNLSQTFEPISWLHLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLR 107
Cdd:COG1173   37 LLAPYDPTAQDLAARLQPPSAAHWLGTDQLGRDVLSRLLYGARISLLVGLLAVLIALVIGVLLGLLAGYFGGWVDAVLMR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 108 FIDVGLSIPEFIIMIALASFFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKII 187
Cdd:COG1173  117 LVDVLLAFPSLLLAIALVAVLGPGLLNVILALGLTGWPGYARLVRAQVLSLREREYVEAARALGASPLRIIFRHILPNVL 196

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493201746 188 PAIIVLMVVDFGKIILYISSLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:COG1173  197 PPLIVQATLGIASAILAEAGLSFLGLGVQPPTPSWGTMLSEGRNYLLTAPWLALFPGLAIVLTVLAFNLLGDGLRDAL 274
nickel_nikC TIGR02790
nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of ...
 28-265 5.98e-69

nickel ABC transporter, permease subunit NikC; This family consists of the NikC family of nickel ABC transporter permeases. Operons that contain this protein also contain a homologous permease subunit NikB. Nickel is used in cells as part of urease or certain hydrogenases or superoxide dismutases. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 131837 [Multi-domain]  Cd Length: 258  Bit Score: 213.79  E-value: 5.98e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746   28 FVSSENATKVNLSQTFEPISWLHLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLR 107
Cdd:TIGR02790  20 WIAPHDPLAQNLPMRLLGPSMEYWLGTDHLGRCIFSRLIFGARVSLGSALLVLGLVLTIGLLIGGLAGYIGGRVDEAIMR 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  108 FIDVGLSIPEFIIMIALASFFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKII 187
Cdd:TIGR02790 100 VCDVFLSFPTIILSLAIVGILGPGLENVIIAIVLVHWAWYARMVRGMVVSLKQREFVLAARTSGASHWQIIRRHILPNIL 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493201746  188 PAIIVLMVVDFGKIILYISSLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:TIGR02790 180 SPIIVLATLDIGHVILHIAGLSFLGLGIQPPTPEWGAMLSEAKQYIWTQPLLMIYPGLAILISVMAFNLLGDALRDHL 257
nikC PRK10417
nickel transporter permease NikC; Provisional
 37-265 4.05e-62

nickel transporter permease NikC; Provisional


Pssm-ID: 236687 [Multi-domain]  Cd Length: 272  Bit Score: 196.81  E-value: 4.05e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  37 VNLSQTFEPISWLHLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLRFIDVGLSIP 116
Cdd:PRK10417  34 IDLPSRLLSPDAQHWLGTDHLGRDIFSRLMAGTRVSLGSVMACLLLVLALGLVIGGSAGLLGGRVDQATMRVADMFMTFP 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 117 EFIIMIALASFFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVV 196
Cdd:PRK10417 114 TSILAFFMVGVLGTGLTNVIIAIALSHWAWYARMVRSLVISLRQREFVLAARLSGAGHVRVFIDHLLPAVIPQLLVLATL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 493201746 197 DFGKIILYISSLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:PRK10417 194 DIGHMMLHVAGLSFLGLGVTAPTAEWGVMINDARQYIWTQPLLMFWPGLALFISVMAFNLLGDALRDHL 262
SapC COG4171
ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];
50-271 7.78e-51

ABC-type antimicrobial peptide export system, permease component SapC [Defense mechanisms];


Pssm-ID: 443331 [Multi-domain]  Cd Length: 296  Bit Score: 168.46  E-value: 7.78e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  50 HLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLRFIDVGLSIPEFIIMIALASFFQ 129
Cdd:COG4171   76 FFLGTDDLGRDILSRLLYGARYTFGSALLVVLAAAIIGGIIGILAGMSRGLKSSILNHLLDTLLSIPSLLLAIIIVALLG 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 130 PSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVVDFGKIILYISSLS 209
Cdd:COG4171  156 PGLENAMLAITLALLPQFIHAIYQAVHQELKKEYVLAARLDGASNWQLLRYSILPNILEVLVTELTRALSIAILDISALG 235

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493201746 210 FIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRdRLLKQRGE 271
Cdd:COG4171  236 FLGLGAQLPSPEWGAMLGDSLELIYLAPWTVILPGLAIMFSVLIVNLVGDGLR-RALNKGVE 296
PRK09881 PRK09881
D,D-dipeptide ABC transporter permease;
28-265 5.73e-50

D,D-dipeptide ABC transporter permease;


Pssm-ID: 182131 [Multi-domain]  Cd Length: 296  Bit Score: 166.53  E-value: 5.73e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  28 FVSSENATKVNLSQTFEPISWLHLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLR 107
Cdd:PRK09881  52 WLATHDPNAIDLTARLLPPSAAHWFGTDEVGRDLFSRVLVGSQQSILAGLVVVAIAGMIGSLLGCLSGVLGGRADAIIMR 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 108 FIDVGLSIPEFIIMIALASFFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKII 187
Cdd:PRK09881 132 IMDIMLSIPSLVLTMALAAALGPSLFNAMLAIAIVRIPFYVRLARGQALVVRQYTYVQAAKTFGASRWHLISWHILRNSL 211

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493201746 188 PAIIVLMVVDFGKIILYISSLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:PRK09881 212 PPLIVQASLDIGSAILMAATLGFIGLGAQQPSAEWGAMVANGRNYVLDQWWYCAFPGAAILLTAVGFNLFGDGIRDLL 289
PRK15082 PRK15082
glutathione ABC transporter permease GsiD; Provisional
 47-265 6.32e-50

glutathione ABC transporter permease GsiD; Provisional


Pssm-ID: 185040 [Multi-domain]  Cd Length: 301  Bit Score: 166.44  E-value: 6.32e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  47 SWLHLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLRFIDVGLSIPEFIIMIALAS 126
Cdd:PRK15082  77 SLQHWFGVDSLGRDIFSRILVGARISLAAGFFSVAIGAAIGTVLGLLAGYYEGWWDRIIMRICDVLFAFPGILLAIAVVA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 127 FFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVVDFGKIILYIS 206
Cdd:PRK15082 157 ILGSGMANVIIAVAIFSIPAFARLVRGNTLVLKQQTYIESARSIGASDWTILLRHILPGTVSSIVVYFTMRIGTSIITAA 236

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 493201746 207 SLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:PRK15082 237 SLSFLGLGAQPPTPEWGAMLNEARADMVIAPHVALFPSLAIFLTVLAFNLLGDGLRDAL 295
PRK10913 PRK10913
dipeptide ABC transporter permease DppC;
47-268 3.33e-49

dipeptide ABC transporter permease DppC;


Pssm-ID: 182833 [Multi-domain]  Cd Length: 300  Bit Score: 164.57  E-value: 3.33e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  47 SWLHLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLRFIDVGLSIPEFIIMIALAS 126
Cdd:PRK10913  76 SWAHILGTDDVGRDVLSRLMYGARLSLLVGCLVVVLSLVMGVILGLIAGYFGGLVDNIIMRVVDIMLALPSLLLALVLVA 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 127 FFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVVDFGKIILYIS 206
Cdd:PRK10913 156 IFGPSIVNAALALTFVALPHYVRLTRAAVLVEVNRDYVTASRVAGAGAMRQMFINILPNCLAPLIVQASLGFSNAILDMA 235

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493201746 207 SLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL---LKQ 268
Cdd:PRK10913 236 ALGFLGMGAQPPTPEWGTMLSDVLQFAQSAWWVVTFPGLAILLTVLAFNLMGDGLRDALdpkLKQ 300
YejE COG4239
ABC-type microcin C transport system, permease component YejE [Secondary metabolites ...
 45-263 5.63e-38

ABC-type microcin C transport system, permease component YejE [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443381 [Multi-domain]  Cd Length: 342  Bit Score: 136.43  E-value: 5.63e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  45 PISWLHLLGTDDYGRDLFTRIIIGAR-STLFVTVLTLIAiVVIGVTLGLFAGYKKGWIERLVLRFIDVGLSIPEFIIMIA 123
Cdd:COG4239  116 PPSAENWLGTDDQGRDVLARLIYGFRiSVLFGLALTVIS-SVIGVAAGAVQGYFGGRVDLLFQRFIEIWSSMPELYLLII 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 124 LASFFQPSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVVDFGKIIL 203
Cdd:COG4239  195 LSSIFQPSFWLLLGILLLFGWMGLVGVVRAEFLRARNLEYVRAARALGVSDRRIMFRHILPNAMVATLTFLPFILSGAIT 274

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 204 YISSLSFIGLGAQPPTPEWGAMLQQGRDFISShPIMLIAPASVIAITILIFNLTGDALRD 263
Cdd:COG4239  275 TLTSLDFLGFGLPPGSPSLGELLAQGKNNLQA-PWLGLSAFVVLALMLSLLVFIGEAVRD 333
PRK15406 PRK15406
oligopeptide ABC transporter permease OppC; Provisional
 50-265 7.04e-38

oligopeptide ABC transporter permease OppC; Provisional


Pssm-ID: 185304 [Multi-domain]  Cd Length: 302  Bit Score: 135.35  E-value: 7.04e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  50 HLLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLRFIDVGLSIPEFIIMIALASFFQ 129
Cdd:PRK15406  82 HYFGTDSSGRDLLVRVAIGGRISLMVGVAAALVAVVVGTLYGSLSGYLGGKVDSVMMRLLEILNSFPFMFFVILLVTFFG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 130 PSLWNLVISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVVDFGKIILYISSLS 209
Cdd:PRK15406 162 QNILLIFVAIGMVSWLDMARIVRGQTLSLKRKEFIEAAQVGGVSTRGIVLRHIVPNVLGVVVVYASLLVPSMILFESFLS 241

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493201746 210 FIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:PRK15406 242 FLGLGTQEPLSSWGALLSDGANSMEVSPWLLLFPAGFLVVTLFCFNFIGDGLRDAL 297
PRK15111 PRK15111
peptide ABC transporter permease SapC;
45-262 2.04e-34

peptide ABC transporter permease SapC;


Pssm-ID: 185066 [Multi-domain]  Cd Length: 296  Bit Score: 125.97  E-value: 2.04e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  45 PISWLH------LLGTDDYGRDLFTRIIIGARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLRFIDVGLSIPEF 118
Cdd:PRK15111  65 PPSWSRygevsfFLGTDDLGRDVLSRLLSGAAPTVGGAFVVTLAATLCGLVLGVFAGATHGLRSAVLNHILDTLLSIPSL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 119 IIMIALASFFQPSLWNLVISItvikWMNYT-RLTRSI---VNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLM 194
Cdd:PRK15111 145 LLAIIVVAFAGPSLSHAMFAV----WLALLpRMVRSIysaVHDELEKEYVIAARLDGASTLNILWYAVLPNITAGLVTEI 220

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 493201746 195 VVDFGKIILYISSLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASVIAITILIFNLTGDALR 262
Cdd:PRK15111 221 TRALSMAILDIAALGFLDLGAQLPSPEWGAMLGDSLELIYVAPWTVMLPGAAIMLSVLLVNLLGDGIR 288
PRK15021 PRK15021
microcin C ABC transporter permease; Provisional
 34-263 2.49e-29

microcin C ABC transporter permease; Provisional


Pssm-ID: 184982 [Multi-domain]  Cd Length: 341  Bit Score: 113.54  E-value: 2.49e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  34 ATKVNLSQTF---EPISWLHLLGTDDYGRDLFTRIIIGAR-STLFVTVLTLIAiVVIGVTLGLFAGYKKGWIERLVLRFI 109
Cdd:PRK15021 102 ATSINFATDKpfpSPPSRQNWLGTDANGGDVLARILYGTRiSVLFGLMLTLCS-SVMGVLAGALQGYYGGKVDLWGQRFI 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 110 DVGLSIPEFIIMIALASFFQPSLWNLvISITVI-KWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIP 188
Cdd:PRK15021 181 EVWSGMPTLFLIILLSSVVQPNFWWL-LAITVLfGWMSLVGVVRAEFLRTRNFDYIRAAQALGVSDRSIILRHMLPNAMV 259

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493201746 189 AIIVLMVVDFGKIILYISSLSFIGLGAQPPTPEWGAMLQQGRDFISSHPIMLIAPASV-IAITILIFnlTGDALRD 263
Cdd:PRK15021 260 ATLTFLPFILCSSITTLTSLDFLGFGLPLGSPSLGELLLQGKNNLQAPWLGITAFLSVaILLSLLIF--IGEAVRD 333
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 69-253 1.95e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 78.09  E-value: 1.95e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  69 ARSTLFVTVLTLIAIVVIGVTLGLFAGYKKGWIERLVLRFIDVGLSIPEFIIMIALASFF--------QPSLWNLVISIT 140
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFgvllgwgiLPGLGLPALILA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 141 VIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVVDFGKIILYISSLSFIGLGAqPPTP 220
Cdd:cd06261   81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE-APGP 159

                        170       180       190
                 ....*....|....*....|....*....|...
gi 493201746 221 EWGAMLQQGRDFisshPIMLIAPASVIAITILI 253
Cdd:cd06261  160 GTGLLLIFAILF----PGDLGVAAAVALILLLL 188
DppB COG0601
ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid ...
 56-202 4.18e-14

ABC-type dipeptide/oligopeptide/nickel transport system, permease component [Amino acid transport and metabolism, Inorganic ion transport and metabolism];


Pssm-ID: 440366 [Multi-domain]  Cd Length: 314  Bit Score: 70.87  E-value: 4.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  56 DYGRDLFTRI----IIGAR--STLFVTVLTLIAIVVIGVTLGLFAGYKKG-WIERLVLRFIDVGLSIPEFII-------- 120
Cdd:COG0601   76 DLGTSFVYGRpvsdLIAERlpVTLELALLALLLALLIGIPLGILAALRRGsWLDRLITVLALLGISIPSFWLglllillf 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746 121 -----------MIALASFFQPSLWNLV---ISITVIKWMNYTRLTRSIVNSEMNKPYIKMAQLFHVPTRTILIRHLTPKI 186
Cdd:COG0601  156 avklgwlpvsgRVSPWEDFLDALRHLIlpaLTLALGSLAGIARLTRSSMLEVLGQDYVRTARAKGLSERRVLLRHALRNA 235

                        170
                 ....*....|....*.
gi 493201746 187 IPAIIVLMVVDFGKII 202
Cdd:COG0601  236 LIPVVTVLGLQLGGLL 251
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 87-265 2.65e-13

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 66.55  E-value: 2.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746   87 GVTLGLFAG-YKKGWIERLVLRFIDVGLSIPEFIIMIALASFFQPSLWNL----VISITVIKWMNYTRLTRSIVNSEMNK 161
Cdd:pfam00528   1 GIPLGIIAAlRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHgilpAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493201746  162 PYIKMAQLFHVPTRTILIRHLTPKIIPAIIVLMVVDFGKIILYISSLSFI----GLGAQPPTPEWGAMLQqgrdfisshp 237
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYP---------- 150

                         170       180
                  ....*....|....*....|....*...
gi 493201746  238 iMLIAPASVIAITILIFNLTGDALRDRL 265
Cdd:pfam00528 151 -EIQGPVLAAALILLLLNLLVDILQRLL 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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