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Conserved domains on  [gi|493212095|ref|WP_006196774|]
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DUF488 family protein [Nodularia spumigena]

Protein Classification

DUF488 family protein( domain architecture ID 10009342)

DUF488 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5483 COG5483
Uncharacterized conserved protein, DUF488 family [Function unknown];
7-149 1.85e-48

Uncharacterized conserved protein, DUF488 family [Function unknown];


:

Pssm-ID: 444234  Cd Length: 147  Bit Score: 152.68  E-value: 1.85e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493212095   7 LFTIGFTQKKAEQFFETLIKAGVKRVIDTRLNNVSQL-AGFAKKNdLEYFLRKIGeIEYIHILDLAPTKDILEEYKK--- 82
Cdd:COG5483    3 LFTIGHSTRSLEEFLALLKAAGVTVLVDVRSNPGSRKnPGFNKEA-LAAALAEAG-IEYVHLPELGGRREGRKAYKKspn 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493212095  83 ---KQINWALYEKRFNQLITERQIEKKVNSDLLDEACLLCSEAKPHNCHRRLVAEYLQNKlntPIKIHHL 149
Cdd:COG5483   81 gcwRNESFRDYADYMLTPEFRRGLEELLELAAGRRIALMCSEADPWRCHRRLVADYLVAR---GVEVVHI 147
 
Name Accession Description Interval E-value
COG5483 COG5483
Uncharacterized conserved protein, DUF488 family [Function unknown];
7-149 1.85e-48

Uncharacterized conserved protein, DUF488 family [Function unknown];


Pssm-ID: 444234  Cd Length: 147  Bit Score: 152.68  E-value: 1.85e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493212095   7 LFTIGFTQKKAEQFFETLIKAGVKRVIDTRLNNVSQL-AGFAKKNdLEYFLRKIGeIEYIHILDLAPTKDILEEYKK--- 82
Cdd:COG5483    3 LFTIGHSTRSLEEFLALLKAAGVTVLVDVRSNPGSRKnPGFNKEA-LAAALAEAG-IEYVHLPELGGRREGRKAYKKspn 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493212095  83 ---KQINWALYEKRFNQLITERQIEKKVNSDLLDEACLLCSEAKPHNCHRRLVAEYLQNKlntPIKIHHL 149
Cdd:COG5483   81 gcwRNESFRDYADYMLTPEFRRGLEELLELAAGRRIALMCSEADPWRCHRRLVADYLVAR---GVEVVHI 147
DUF488 pfam04343
Protein of unknown function, DUF488; This family includes several proteins of uncharacterized ...
 16-136 1.10e-30

Protein of unknown function, DUF488; This family includes several proteins of uncharacterized function.


Pssm-ID: 427880  Cd Length: 123  Bit Score: 107.00  E-value: 1.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493212095   16 KAEQFFETLIKAGVKRVIDTRLNNVSQLAGFaKKNDLEYFLRKIGeIEYIHILDLAPTKDILEEYKKKQIN---WALYEK 92
Cdd:pfam04343   1 SIKRFYDLLKADGIRVLVDVRLWPRSRNPGF-SKEALALDLAEAG-IAYVWLKELGPSRELRKWFHHDPNWdefFRRYAA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 493212095   93 RFNQLITERQIEKKVNSDLLDEA-CLLCSEAKPHNCHRRLVAEYL 136
Cdd:pfam04343  79 ELLTPPAFREALDRLLELARKGPvTLLCAEKDPEHCHRVVLADYL 123
MYSc_Myo11 cd01384
class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle ...
 78-147 7.91e-04

class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle transport. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle.


Pssm-ID: 276835  Cd Length: 647  Bit Score: 38.43  E-value: 7.91e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493212095  78 EEYKKKQINWALYEKRFNQLITErQIEKKVNS--DLLDEACLLcseakPHNCHrrlvaEYLQNKLNTPIKIH 147
Cdd:cd01384  398 EEYTKEEIDWSYIEFVDNQDVLD-LIEKKPGGiiALLDEACMF-----PRSTH-----ETFAQKLYQTLKDH 458
 
Name Accession Description Interval E-value
COG5483 COG5483
Uncharacterized conserved protein, DUF488 family [Function unknown];
7-149 1.85e-48

Uncharacterized conserved protein, DUF488 family [Function unknown];


Pssm-ID: 444234  Cd Length: 147  Bit Score: 152.68  E-value: 1.85e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493212095   7 LFTIGFTQKKAEQFFETLIKAGVKRVIDTRLNNVSQL-AGFAKKNdLEYFLRKIGeIEYIHILDLAPTKDILEEYKK--- 82
Cdd:COG5483    3 LFTIGHSTRSLEEFLALLKAAGVTVLVDVRSNPGSRKnPGFNKEA-LAAALAEAG-IEYVHLPELGGRREGRKAYKKspn 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493212095  83 ---KQINWALYEKRFNQLITERQIEKKVNSDLLDEACLLCSEAKPHNCHRRLVAEYLQNKlntPIKIHHL 149
Cdd:COG5483   81 gcwRNESFRDYADYMLTPEFRRGLEELLELAAGRRIALMCSEADPWRCHRRLVADYLVAR---GVEVVHI 147
DUF488 pfam04343
Protein of unknown function, DUF488; This family includes several proteins of uncharacterized ...
 16-136 1.10e-30

Protein of unknown function, DUF488; This family includes several proteins of uncharacterized function.


Pssm-ID: 427880  Cd Length: 123  Bit Score: 107.00  E-value: 1.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493212095   16 KAEQFFETLIKAGVKRVIDTRLNNVSQLAGFaKKNDLEYFLRKIGeIEYIHILDLAPTKDILEEYKKKQIN---WALYEK 92
Cdd:pfam04343   1 SIKRFYDLLKADGIRVLVDVRLWPRSRNPGF-SKEALALDLAEAG-IAYVWLKELGPSRELRKWFHHDPNWdefFRRYAA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 493212095   93 RFNQLITERQIEKKVNSDLLDEA-CLLCSEAKPHNCHRRLVAEYL 136
Cdd:pfam04343  79 ELLTPPAFREALDRLLELARKGPvTLLCAEKDPEHCHRVVLADYL 123
MYSc_Myo11 cd01384
class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle ...
 78-147 7.91e-04

class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle transport. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle.


Pssm-ID: 276835  Cd Length: 647  Bit Score: 38.43  E-value: 7.91e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493212095  78 EEYKKKQINWALYEKRFNQLITErQIEKKVNS--DLLDEACLLcseakPHNCHrrlvaEYLQNKLNTPIKIH 147
Cdd:cd01384  398 EEYTKEEIDWSYIEFVDNQDVLD-LIEKKPGGiiALLDEACMF-----PRSTH-----ETFAQKLYQTLKDH 458
Myosin_head pfam00063
Myosin head (motor domain);
78-118 8.76e-03

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 35.33  E-value: 8.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 493212095   78 EEYKKKQINWALYEKRFNQLITErQIEKKVNS--DLLDEACLL 118
Cdd:pfam00063 408 EEYVREGIEWTFIDFGDNQPCID-LIEKKPLGilSLLDEECLF 449
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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