|
Name |
Accession |
Description |
Interval |
E-value |
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
1-732 |
0e+00 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 1400.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 1 MDFSLLLDGLNDKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIEYTLSQ 80
Cdd:PRK11773 1 MDVSYLLDSLNDKQREAVAAPLGNMLVLAGAGSGKTRVLVHRIAWLMQVENASPYSIMAVTFTNKAAAEMRHRIEQLLGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 81 SGDnrlfGMWVGTFHSIANRLLRSHYLDADLPQDFQIMDTEDQQRLLKRLLKLHNIDEKHFPPKHVAWYINAQKDKGKRA 160
Cdd:PRK11773 81 SQG----GMWVGTFHGLAHRLLRAHWQDANLPQDFQILDSDDQLRLLKRLIKALNLDEKQWPPRQAQWYINGQKDEGLRP 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 161 KDIDHHNDPNEKKLVEIYQIYQDACDRAGLLDFAELLIRAYELFKTKPTILQRYQQRFQQILIDEFQDTNNIQYDLIRLL 240
Cdd:PRK11773 157 QHIQSYGDPVEQTWLKIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYQERFTHILVDEFQDTNAIQYAWIRLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 241 AGDVGKVMIVGDDDQSIYGWRGAQVENIQRFLNDYDNAQTIRLEQNYRSTGNILSCANELIANNDNRLGKNLWTDSGDGE 320
Cdd:PRK11773 237 AGDTGKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTANILKAANALIANNNGRLGKELWTDGGDGE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 321 PVDIYCAFNELDEARFVASQIKQWKEDEGDLAECAVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLR 400
Cdd:PRK11773 317 PISLYCAFNELDEARFVVERIKTWQDNGGALSDCAILYRSNAQSRVLEEALLQAGIPYRIYGGMRFFERQEIKDALAYLR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 401 LIANRQDDAAFERVINTPTRGIGDRTLDTLRQITRGRQITLWQAIQVAVQEEQLSGRATSSLLRFVELINALDQETEQMS 480
Cdd:PRK11773 397 LIANRNDDAAFERVVNTPTRGIGDRTLDVVRQTARDRQLTLWQACRALLQEKVLAGRAASALQRFIELIDALAQETADMP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 481 LAEQTDFVIKKSGLYEMYKQEKGEKGEVRIENLEELVTATKQFVKPDEAEELTDLTAFLTHASLEAGEAQASQHEDYVEL 560
Cdd:PRK11773 477 LHEQTDRVIKDSGLRAMYEQEKGEKGQARIENLEELVTATRQFSYPDEDEDLTPLQAFLSHAALEAGEGQADAHEDAVQL 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 561 MTLHSAKGLEFPRVFIVGVEEGIFPSGMSFDE-GRLQEERRLAYVGITRAKKKLTISYAESRRLYGKEERHVPSRFIAEL 639
Cdd:PRK11773 557 MTLHSAKGLEFPLVFIVGMEEGLFPSQMSLEEgGRLEEERRLAYVGITRAMQKLTLTYAESRRLYGKEVYHRPSRFIREI 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 640 PEEHIREVRLRGSINRAASFNQansfaknpTKTTASFLNDDTWKMGQKVNHAKFGQGTIINVEGSGEATRLQVAFVGNGI 719
Cdd:PRK11773 637 PEECVEEVRLRATVSRPVSHQR--------MGTPAVEANDSGFKLGQRVRHPKFGEGTIVNFEGSGAHARVQVAFQGQGI 708
|
730
....*....|...
gi 493294436 720 KWLIAKMANLERI 732
Cdd:PRK11773 709 KWLVAAYAKLEAV 721
|
|
| uvrD |
TIGR01075 |
DNA helicase II; Designed to identify uvrD members of the uvrD/rep subfamily. [DNA metabolism, ... |
6-730 |
0e+00 |
|
DNA helicase II; Designed to identify uvrD members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130147 [Multi-domain] Cd Length: 715 Bit Score: 1176.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 6 LLDGLNDKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIEYTLSQSGDnr 85
Cdd:TIGR01075 1 LLDGLNDKQREAVAAPPGNLLVLAGAGSGKTRVLTHRIAWLLSVENASPHSIMAVTFTNKAAAEMRHRIGALLGTSAR-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 86 lfGMWVGTFHSIANRLLRSHYLDADLPQDFQIMDTEDQQRLLKRLLKLHNIDEKHFPPKHVAWYINAQKDKGKRAKDIDH 165
Cdd:TIGR01075 79 --GMWIGTFHGLAHRLLRAHHLDAGLPQDFQILDSDDQLRLLKRLIKALNLDEKQWPPRQAMWYINNQKDEGLRPSHIQA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 166 HNDPNEKKLVEIYQIYQDACDRAGLLDFAELLIRAYELFKTKPTILQRYQQRFQQILIDEFQDTNNIQYDLIRLLAGDVG 245
Cdd:TIGR01075 157 FDNPVERTWIKIYQAYQEACDRAGLVDFAELLLRAHELLRNKPHILQHYQERFTHILVDEFQDTNKIQYAWIRLLAGNTG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 246 KVMIVGDDDQSIYGWRGAQVENIQRFLNDYDNAQTIRLEQNYRSTGNILSCANELIANNDNRLGKNLWTDSGDGEPVDIY 325
Cdd:TIGR01075 237 NVMIVGDDDQSIYGWRGAQVENIQKFLKDFPGAETIRLEQNYRSTANILAAANALIANNDERLGKNLWTDGEVGEPISLY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 326 CAFNELDEARFVASQIKQWKEDEGDLAECAVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLRLIANR 405
Cdd:TIGR01075 317 SAFNELDEARFVVSRIKTWQRNGGALDECAVLYRSNAQSRVLEEALLQASIPYRIYGGMRFFERQEIKDALAYLRLIANR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 406 QDDAAFERVINTPTRGIGDRTLDTLRQITRGRQITLWQAIQVAVQEEQLSGRATSSLLRFVELINALDQETEQMSLAEQT 485
Cdd:TIGR01075 397 NDDAAFERVINTPTRGIGDRTLDVVRQAARDRGLTLWQAARELTQEKVLAGRAASALQRFVELIEALANETADMPLHVQT 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 486 DFVIKKSGLYEMYKQEKGEKGEVRIENLEELVTATKQFVKPDEAEELTDLTAFLTHASLEAGEAQASQHEDYVELMTLHS 565
Cdd:TIGR01075 477 DHVIKDSGLREMYQQEKGEKGQARIENLEELVTATRQFSLPENDEDMTPLTAFLSHAALEAGEGQADAGQDAVQLMTLHS 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 566 AKGLEFPRVFIVGVEEGIFPSGMSFDE-GRLQEERRLAYVGITRAKKKLTISYAESRRLYGKEERHVPSRFIAELPEEHI 644
Cdd:TIGR01075 557 AKGLEFPLVFLVGMEEGMFPSQMSLDEgGRLEEERRLAYVGITRAMQKLTITYAETRRLYGKEVYHIPSRFIRELPEECL 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 645 REVRLRGSINRAASFNQANSFAKNPtkttasfLNDDTWKMGQKVNHAKFGQGTIINVEGSGEATRLQVAFVGNGIKWLIA 724
Cdd:TIGR01075 637 HEVRLRAQVSRPTNLGRVGTPSVDE-------INDAGFKLGQRVRHPKFGEGTIINAEGSGEHSRLQIAFQGQGIKWLVA 709
|
....*.
gi 493294436 725 KMANLE 730
Cdd:TIGR01075 710 AYAKLE 715
|
|
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
6-670 |
0e+00 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 907.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 6 LLDGLNDKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIEYTLSQSGDnr 85
Cdd:COG0210 3 LLAGLNPEQRAAVEHPEGPLLVLAGAGSGKTRVLTHRIAYLIAEGGVDPEQILAVTFTNKAAREMRERIEALLGRLAR-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 86 lfGMWVGTFHSIANRLLRSHYLDADLPQDFQIMDTEDQQRLLKRLLKLHNIDEKHFPPKHVAWYINAQKDKGKRAKDIDH 165
Cdd:COG0210 81 --GLWVGTFHSLALRILRRHAELLGLPPNFTILDGDDQLRLIKELLKELGLDEKRFPPRELLSLISRAKNEGLTPEELAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 166 H--NDPNEKKLVEIYQIYQDACDRAGLLDFAELLIRAYELFKTKPTILQRYQQRFQQILIDEFQDTNNIQYDLIRLLAGD 243
Cdd:COG0210 159 LlaADPEWRAAAELYEAYQERLRANNALDFDDLLLLAVRLLEENPEVLEKYQNRFRYILVDEYQDTNPAQYELLRLLAGD 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 244 VGKVMIVGDDDQSIYGWRGAQVENIQRFLNDYDNAQTIRLEQNYRSTGNILSCANELIANNDNRLGKNLWTDSGDGEPVD 323
Cdd:COG0210 239 GRNLCVVGDDDQSIYGFRGADPENILRFEKDFPDAKVIKLEQNYRSTQNILDAANAVIANNPGRLGKNLWTDNGEGEKVR 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 324 IYCAFNELDEARFVASQIKQWKEDEGDLAECAVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLRLIA 403
Cdd:COG0210 319 LYVAPDEEEEARFVADEIRELHEEGVPLSDIAVLYRTNAQSRALEEALRRAGIPYRVVGGLRFYERAEIKDLLAYLRLLA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 404 NRQDDAAFERVINTPTRGIGDRTLDTLRQITRGRQITLWQAIQVAVQEEQLSGRATSSLLRFVELINALDQETEQMSLAE 483
Cdd:COG0210 399 NPDDDVALLRILNVPRRGIGAATLERLREAAREEGISLLEALRDLGELAGLSGRAAKALRRFAELLEALRAAAERLPLEE 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 484 QTDFVIKKSGLYEMYKQEKGEKGEVRIENLEELVTATKQFVkpdEAEELTDLTAFLTHASLEAGEAQASQHEDYVELMTL 563
Cdd:COG0210 479 LLEALLDESGYEEELREEAGEEAERRLENLEELVDAAARFE---ERNPGASLEAFLEELALLSDLDAADEDEDAVTLMTL 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 564 HSAKGLEFPRVFIVGVEEGIFPSGMSF-DEGRLQEERRLAYVGITRAKKKLTISYAESRRLYGKEERHVPSRFIAELPEE 642
Cdd:COG0210 556 HAAKGLEFPVVFLVGLEEGLFPHQRSLdDEEELEEERRLFYVAITRARERLYLTYAASRRLWGETQDNEPSRFLDELPEE 635
|
650 660
....*....|....*....|....*...
gi 493294436 643 HIREVRLRGSINRAASFNQANSFAKNPT 670
Cdd:COG0210 636 LLEWVRPKAEAAAAAASAAAALPASGAG 663
|
|
| pcrA |
TIGR01073 |
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. ... |
6-730 |
0e+00 |
|
ATP-dependent DNA helicase PcrA; Designed to identify pcrA members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273429 [Multi-domain] Cd Length: 726 Bit Score: 749.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 6 LLDGLNDKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIEYTLSQSGDnr 85
Cdd:TIGR01073 1 LLAHLNPEQREAVKTTEGPLLIMAGAGSGKTRVLTHRIAHLIAEKNVAPWNILAITFTNKAAREMKERVEKLLGPVAE-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 86 lfGMWVGTFHSIANRLLRSHYLDADLPQDFQIMDTEDQQRLLKRLLKLHNIDEKHFPPKHVAWYINAQKDKGKRAKDIDH 165
Cdd:TIGR01073 79 --DIWISTFHSMCVRILRRDIDRIGINRNFSIIDPTDQLSLMKTILKDKNLDPKKFEPRSILGTISNAKNELLPPEDFAK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 166 HN-DPNEKKLVEIYQIYQDACDRAGLLDFAELLIRAYELFKTKPTILQRYQQRFQQILIDEFQDTNNIQYDLIRLLAGDV 244
Cdd:TIGR01073 157 EAtNYFEKVVAEVYQEYQKRLLRNNALDFDDLIMTTINLFQRVPDVLEYYQRKFQYIHVDEYQDTNRAQYTLVRLLASRF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 245 GKVMIVGDDDQSIYGWRGAQVENIQRFLNDYDNAQTIRLEQNYRSTGNILSCANELIANNDNRLGKNLWTDSGDGEPVDI 324
Cdd:TIGR01073 237 RNLCVVGDADQSIYGWRGADIQNILSFEKDYPNATTILLEQNYRSTKNILQAANEVIEHNSNRKPKNLWTENSSGDKITY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 325 YCAFNELDEARFVASQIKQW-KEDEGDLAECAVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLRLIA 403
Cdd:TIGR01073 317 YEADTERDEAQFVAGEIDKLvKNGERKYGDFAILYRTNAQSRVFEETLLKANIPYKIVGGLKFYDRKEIKDILAYLRVIA 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 404 NRQDDAAFERVINTPTRGIGDRTLDTLRQITRGRQITLWQAIQVAVQEEQLSGRATSSLLRFVELINALDQETEQMSLAE 483
Cdd:TIGR01073 397 NPDDDLSLLRIINVPKRGIGASSLEKIVNYALELNISLFEAIGEIDEIGGLAAKSANALLAFATMIENLRQQQEYLSPTE 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 484 QTDFVIKKSGLYEMYKQEKGEKGEVRIENLEELVTATKQFvkPDEAEELTdLTAFLTHASLEAGEAQASQHE--DYVELM 561
Cdd:TIGR01073 477 LVEEVLDKSGYREMLKAEKTEEAQSRLENLDEFLSVTKEF--EDESEDKS-LIDFLTDLALVSDLDELEETEegGAVTLM 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 562 TLHSAKGLEFPRVFIVGVEEGIFPSGMSF-DEGRLQEERRLAYVGITRAKKKLTISYAESRRLYGKEERHVPSRFIAELP 640
Cdd:TIGR01073 554 TLHAAKGLEFPVVFLIGMEEGVFPHSRSLmDEKELEEERRLAYVGITRAEEELYLTHATMRTLFGRIQMNPPSRFLNEIP 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 641 EEHIREVR--LRGSINRAASFNQANSFAKNPTKTTASFLNDDT-WKMGQKVNHAKFGQGTIINVEGSGEATRLQVAFVGN 717
Cdd:TIGR01073 634 AELLETAStgRRTGATDPKGPSIRQAGASRPTTSQPTAGGDTLsWAVGDRVNHKKWGIGTVVSVKGGGDDQELDIAFPSI 713
|
730
....*....|...
gi 493294436 718 GIKWLIAKMANLE 730
Cdd:TIGR01073 714 GVKRLLAAFAPIE 726
|
|
| rep |
TIGR01074 |
ATP-dependent DNA helicase Rep; Designed to identify rep members of the uvrD/rep subfamily. ... |
9-644 |
0e+00 |
|
ATP-dependent DNA helicase Rep; Designed to identify rep members of the uvrD/rep subfamily. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 130146 [Multi-domain] Cd Length: 664 Bit Score: 538.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 9 GLNDKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIEYTLsqsGDNRLFG 88
Cdd:TIGR01074 1 KLNPQQQEAVEYVTGPCLVLAGAGSGKTRVITNKIAYLIQNCGYKARNIAAVTFTNKAAREMKERVAKTL---GKGEARG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 89 MWVGTFHSIANRLLRSHYLDADLPQDFQIMDTEDQQRLLKRLLKLHNIDEKHFPPKHVAwYINAQKDKGKRAKD-IDHHN 167
Cdd:TIGR01074 78 LTISTFHTLGLDIIKREYNALGYKSNFSLFDETDQLALLKELTEGLIKDDKDLLDKLIS-TISNWKNDLLTPEQaLASAR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 168 DPNEKKLVEIYQIYQDACDRAGLLDFAELLIRAYELFKTKPTILQRYQQRFQQILIDEFQDTNNIQYDLIRLLAGDVGKV 247
Cdd:TIGR01074 157 GEREQTFAHCYALYQAHLRAYNALDFDDLILLPTLLLQQNEEVRNRWQNKIRYLLVDEYQDTNTSQYELVKLLVGDRARF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 248 MIVGDDDQSIYGWRGAQVENIQRFLNDYDNAQTIRLEQNYRSTGNILSCANELIANNDNRLGKNLWTDSGDGEPVDIYCA 327
Cdd:TIGR01074 237 TVVGDDDQSIYSWRGARPENLVLLKEDFPQLKVIKLEQNYRSTGRILKAANILIANNPHVFEKKLFSELGYGEKIKVIEC 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 328 FNELDEARFVASQI-KQWKEDEGDLAECAVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLRLIANRQ 406
Cdd:TIGR01074 317 NNEEHEAERIAGEIiAHKLVNKTQYKDYAILYRGNHQSRLLEKALMQNRIPYKLSGGTSFFSRPEIKDLLSYLRLLVNPD 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 407 DDAAFERVINTPTRGIGDRTLDTLRQITRGRQITLWQAIQVAVQEEQLSGRATSSLLRFVELINALDQETEQMSLAEQTD 486
Cdd:TIGR01074 397 DDAAFLRIVNTPKREIGPATLEKLGELAMERNKSLFTASFDMGLLQTLSGRGYESLQRFTDWLVEIRRLAERSEPIEAVR 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 487 FVIKKSGlYE--MYKQEKGEKG-EVRIENLEELVTATKQFVK---PDEAEELTDLTAFLTHAS-LEAGEAQasQHEDYVE 559
Cdd:TIGR01074 477 SLIEDID-YEnwLYETSPSPKAaEMRMKNVNTLFSWFKEMLEgdeEDEPMTLTQVVTRLTLRDmLERGEDE--EELDQVQ 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 560 LMTLHSAKGLEFPRVFIVGVEEGIFPSGMSFDEGRLQEERRLAYVGITRAKKKLTISYAESRRLYGKEERHVPSRFIAEL 639
Cdd:TIGR01074 554 LMTLHASKGLEFPYVFIVGMEEGILPHQSSIEEDNVEEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEPSRFLDEL 633
|
....*
gi 493294436 640 PEEHI 644
Cdd:TIGR01074 634 PQEDL 638
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
10-642 |
1.98e-154 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 463.93 E-value: 1.98e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 10 LNDKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIEYTLsqsGDNRLFGM 89
Cdd:PRK10919 3 LNPGQQQAVEFVTGPCLVLAGAGSGKTRVITNKIAHLIRGCGYQARHIAAVTFTNKAAREMKERVAQTL---GRKEARGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 90 WVGTFHSIANRLLRSHYLDADLPQDFQIMDTEDQQRLLKRLLKLHNIDEKHFPPKHVAWYINAQKDKGKRAKDIDHHNDP 169
Cdd:PRK10919 80 MISTFHTLGLDIIKREYAALGMKSNFSLFDDTDQLALLKELTEGLIEDDKVLLQQLISTISNWKNDLKTPAQAAAGAKGE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 170 NEKKLVEIYQIYQDACDRAGLLDFAELLIRAYELFKTKPTILQRYQQRFQQILIDEFQDTNNIQYDLIRLLAGDVGKVMI 249
Cdd:PRK10919 160 RDRIFAHCYGLYDAHLKACNVLDFDDLILLPTLLLQRNEEVRERWQNKIRYLLVDEYQDTNTSQYELVKLLVGSRARFTV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 250 VGDDDQSIYGWRGAQVENIQRFLNDYDNAQTIRLEQNYRSTGNILSCANELIANNDNRLGKNLWTDSGDGEPVDIYCAFN 329
Cdd:PRK10919 240 VGDDDQSIYSWRGARPQNLVLLSQDFPALQVIKLEQNYRSSGRILKAANILIANNPHVFEKRLFSELGYGDELKVLSANN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 330 ELDEA-RFVASQIKQWKEDEGDLAECAVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLRLIANRQDD 408
Cdd:PRK10919 320 EEHEAeRVTGELIAHHFVNKTQYKDYAILYRGNHQSRVFEKFLMQNRIPYKISGGTSFFSRPEIKDLLAYLRVLTNPDDD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 409 AAFERVINTPTRGIGDRTLDTLRQITRGRQITLWQAIQVAVQEEQLSGRATSSLLRFVELINALDQETEQMSLAEQTDFV 488
Cdd:PRK10919 400 SAFLRIVNTPKREIGPATLQKLGEWAMTRNKSLFTASFDMGLSQTLSGRGYESLTRFTHWLAEIQRLAEREPVAAVRDLI 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 489 IK---KSGLYEMYKQEKGekGEVRIENLEELVTATKQFVKPDEAEELTDLTAFLTHASL----EAGEAQasQHEDYVELM 561
Cdd:PRK10919 480 HGidyESWLYETSPSPKA--AEMRMKNVNQLFSWMTEMLEGSELDEPMTLTQVVTRFTLrdmmERGESE--EELDQVQLM 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 562 TLHSAKGLEFPRVFIVGVEEGIFPSGMSFDEGRLQEERRLAYVGITRAKKKLTISYAESRRLYGKEERHVPSRFIAELPE 641
Cdd:PRK10919 556 TLHASKGLEFPYVYLVGMEEGLLPHQSSIDEDNIDEERRLAYVGITRAQKELTFTLCKERRQYGELVRPEPSRFLLELPQ 635
|
.
gi 493294436 642 E 642
Cdd:PRK10919 636 D 636
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
10-622 |
1.23e-108 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 350.42 E-value: 1.23e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 10 LNDKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRI------------EYT 77
Cdd:COG1074 6 WTDAQRRALDPLGGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIrerlaeaadledPDL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 78 LSQSGDNRLF--------GMWVGTFHSIANRLLRSHYLDADLPQDFQIMDTEDQQ------------------------- 124
Cdd:COG1074 86 EELARARRRLaralenldRAAISTIHSFCQRLLREFAFEAGLDPNFELLDDAEALlleeavddllreayapldalalarl 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 125 -------------------RLLKRLLKLHNIDEKHFPPKHVAWYINAQKDKGKRAKDIDHHND-PNEKKLV----EIYQI 180
Cdd:COG1074 166 ldafgrdddsleelllalyKLRSRPDWLEELAELDEALEALREALLKAKEALAALREALAAAAaPLLAALLrllaAVLAR 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 181 YQDACDRAGLLDFAELLIRAYELFKTK--PTILQRYQQRFQQILIDEFQDTNNIQYDLIRLLAGD----VGKVMIVGDDD 254
Cdd:COG1074 246 YERRKRERGLLDFDDLLHRALRLLRDEdaPWVAERLRERYRHILVDEFQDTSPLQWEILRRLAGEaladGRTLFLVGDPK 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 255 QSIYGWRGAQVENIQRFLNDYDN---AQTIRLEQNYRSTGNILSCANELIAN-NDNRLGKNLWTDS-----GDGEPVDIY 325
Cdd:COG1074 326 QSIYRFRGADPELFLEARRALEGrvdGERLTLTTNFRSTPEVVDAVNALFAQlMGAGFGEIPYEPVealrpGAYPAVELW 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 326 C----AFNELD----EARFVASQIKQWKEDEGDLAEC---------AVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFE 388
Cdd:COG1074 406 PlepdDVSEEDarerEARAVAARIRRLLAEGTTVEGGgrpvrpgdiAVLVRTRSEAAAIARALKAAGIPVAASDRLSLFE 485
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 389 RQEIKDALAYLRLIANRQDDAAFERVINTPTRGIGDRTLDTLRQitRGRQITLWQAIqvavqeeqlsgRATSSLLRFVEL 468
Cdd:COG1074 486 SPEVRDLLALLRALLNPEDDLALAAVLRSPLFGLSDEDLAALAA--DRKGESLWEAL-----------RAYERLARALER 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 469 INALDQETEQMSLAEQTDFVIKKSGLYEMYKQEKGekGEVRIEN---LEELVTATKQFvkpdEAEELTDLTAFLTH---- 541
Cdd:COG1074 553 LRALRELARRLGLAELLERLLEETGLLERLLALPG--GERRLANllhLDELLQLALEY----EQTGGPGLAGFLRWlerl 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 542 --ASLEAGEAQASQHEDYVELMTLHSAKGLEFPRVFIVGVEEGIfpsgmsfDEGRLQEERRLAYVGITRAKKKLTISYAE 619
Cdd:COG1074 627 ieDGGDEEKRRLESDADAVRIMTIHKSKGLEFPVVFLPALRERA-------RAEELAEELRLLYVALTRARDRLVLSGAV 699
|
...
gi 493294436 620 SRR 622
Cdd:COG1074 700 KKK 702
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
10-276 |
4.38e-107 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 326.89 E-value: 4.38e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 10 LNDKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIeytLSQSGDNRLFGM 89
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLILEGGIDPEEILAVTFTNKAAREMKERI---LKLLGKAELSEL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 90 WVGTFHSIANRLLRSHYLDADLPQDFQIMDTEDQQRL--LKRLLKLHNIDEKHFPPKHVAWYINAQKDKGKRAKDIDH-H 166
Cdd:pfam00580 78 NISTFHSFCLRILRKYANRIGLLPNFSILDELDQLALlkELLEKDRLNLDPKLLRKLELKELISKAKNRLLSPEELQQgA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 167 NDPNEKKLVEIYQIYQDACDRAGLLDFAELLIRAYELFKTKPTILQRYQQRFQQILIDEFQDTNNIQYDLIRLLAGDVGK 246
Cdd:pfam00580 158 ADPRDKLAAEFYQEYQERLKENNALDFDDLLLLTLELLRSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAGGHEN 237
|
250 260 270
....*....|....*....|....*....|
gi 493294436 247 VMIVGDDDQSIYGWRGAQVENIQRFLNDYD 276
Cdd:pfam00580 238 LFLVGDPDQSIYGFRGADIENILKFEKDFP 267
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
281-620 |
1.14e-97 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 306.64 E-value: 1.14e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 281 IRLEQNYRSTGNILSCANELIANNDNR----LGKNLWTDSGDGEPVDIYCAFNELDEARFVASQIKQWKEDEGDLAECAV 356
Cdd:pfam13361 1 IHLEINYRSTKNLLKAANEFINNNFGRatiyPKKILAETVEDGEKIKIIEAETEEEEAEWIALEIKKLVARDEKYNDIAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 357 LYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLRLIANRQDDAAFERVINTPTRGIGDRTLDTLRQI--- 433
Cdd:pfam13361 81 LTRSNSDADLIEEALKKLGIPYFVVGQTKFFRREEIKDILAYLRLIANKHDSISLKRILNGPKRGIGNATLERIREYkkr 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 434 ----------------------------------TRGRQITLWQAIQVAVQEEQLSGRATSSLLRFVELINALD---QET 476
Cdd:pfam13361 161 glrlsdfinpdtltygdpfvialeqdnivvfdveTTGLDTTEDEIIQIAAIKLNKKGVVIESFERFLRLKKPVGdslQVH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 477 EQMSLAEQTDFVIKKSGLYEMYKqekgekgevRIENLEELVTATKQFVKPDEAEELTD-LTAFLTHASLEAGEAQASQHE 555
Cdd:pfam13361 241 GFSDEFLQENGETPAEALRDFLE---------KLENLRELYSILREYDDIEETPEPEDaLRNFLEIATLSNSELEGSDIK 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493294436 556 DYVELMTLHSAKGLEFPRVFIVGVEEGIFPSGMSF-DEGRLQEERRLAYVGITRAKKKLTISYAES 620
Cdd:pfam13361 312 ERIPIMTIHQAKGLEFDTVFLAGLEEGIFPSYRSIkDEGNLEEERRLFYVAITRAKKRLYISYSKS 377
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
11-287 |
4.00e-85 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 266.69 E-value: 4.00e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 11 NDKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHRIEytlSQSGDNRLFGMW 90
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLILEGGVPPERILAVTFTNKAAKEMRERLR---KLLGEQLASGVW 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 91 VGTFHSIANRLLRSHYldadlpqdfqimdtedqqrllkrllklhnidekhfppkhvawyinaqkdkgkrakdidhhndpn 170
Cdd:cd17932 78 IGTFHSFALRILRRYG---------------------------------------------------------------- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 171 ekklveiyqiyqdacdragllDFAELLIRAYELFKTKPTILQRYQQRFQQILIDEFQDTNNIQYDLIRLLAGDVGKVMIV 250
Cdd:cd17932 94 ---------------------DFDDLLLYALELLEENPDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAGDGKNLFVV 152
|
250 260 270
....*....|....*....|....*....|....*..
gi 493294436 251 GDDDQSIYGWRGAQVENIQRFLNDYDNAQTIRLEQNY 287
Cdd:cd17932 153 GDDDQSIYGFRGADPENILDFEKDFPDAKVIKLEENY 189
|
|
| addA_Gpos |
TIGR02785 |
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, ... |
12-613 |
3.25e-32 |
|
helicase-exonuclease AddAB, AddA subunit, Firmicutes type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the Firmicutes (as modeled here) and the alphaproteobacteria, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274299 [Multi-domain] Cd Length: 1230 Bit Score: 134.45 E-value: 3.25e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 12 DKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLIgVENVPESNILAVTFTNKAAAEMRHRIEYTLS----QSGDNRLF 87
Cdd:TIGR02785 4 DEQWQAIYTRGQDILVSASAGSGKTAVLVERIIRKI-TRGVDVDRLLVVTFTNAAAREMKERIAEALEkelvQEPNSKHL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 88 GMW--------VGTFHSIANRLLRSHYLDADLPQDFQIMDteDQQRLLKRLLKLHNIDEKHF------------------ 141
Cdd:TIGR02785 83 RRQlallntanISTLHSFCLKVIRKHYYLLDLDPSFRILT--DTEQLLLIKEVLDDVFEEEYykedkeaffelvdnfsgd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 142 -------------------PPKHVAW------------------------------------------------------ 148
Cdd:TIGR02785 161 rsddglrdlilqlydfsrsTPNPEKWlnnlaeayevkekftieslklqqqikellkneleglqeklqralelfmaedgla 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 149 ------------------------------------------YINAQKDKGKRAKDIDHHNDPNEKKLVEIYQ------- 179
Cdd:TIGR02785 241 prlenfqldlqnideliqeslaqadwnelrkavaafkfknlkAAKGDEEDADLLEEADKLREEAKKQLEKLKTdyftrse 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 180 -----IYQDACDRA---------------------GLLDFAELLIRAYELFKTKPTILQR----YQQRFQQILIDEFQDT 229
Cdd:TIGR02785 321 edhlrIMQEMKPVVktlvqlvkdfierfgaekrekNILDFSDLEHYALQILTNENESPSEaaefYREKFHEVLVDEYQDT 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 230 NNIQYDLIRLLAGDV---GKVMIVGDDDQSIYGWRGAqveNIQRFLNDY-----DNAQT---IRLEQNYRSTGNILSCAN 298
Cdd:TIGR02785 401 NLVQESILQLVKRGPeeeGNLFMVGDVKQSIYRFRQA---DPLLFLEKYhrfaqEGEEHgkrIDLAENFRSRAEVLDTTN 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 299 ELIA----------NNDN----RLGKNLWTDS---------------GDGEPVDIYCAFNELD----EARFVASQIKQWK 345
Cdd:TIGR02785 478 FLFKqlmdeevgeiDYDEeaqlKFGAAKYPENpdnkteellyeklliEEAEEEEIDEEAEILDkaqqEATMVAERIKALI 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 346 eDEGDL--------------AECAVLYRSNSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLRLIANRQDDAAF 411
Cdd:TIGR02785 558 -KEGFKvydkktgtyrpvtyRDIVILTRSRGWNLQIMEEFKKYGIPVFANDAENYFQTTEVRVMLSLLRVIDNPYQDIPL 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 412 ERVINTPTRGIGDRTLDTLRqiTRGRQITLWQAIQVAVQEEQLSGRATSSLLRFVELINALDQETEQMSLAEQTDFVIKK 491
Cdd:TIGR02785 637 VAVLRSPIVGFDENELALIR--LENKDSSYYEAVKDYVKAGLIEDELYEKLNTFLDSLQKWREFARTHSVSELIWKIYND 714
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 492 SGLYEMYKQEKGekGEVRIENLEELVTATKQFvkpdEAEELTDLTAF------LTHASLEAGEAQA-SQHEDYVELMTLH 564
Cdd:TIGR02785 715 TGYYDYVGGLPG--GKQRQANLYALYERARQY----ESTSFKGLFQFirfierMQERQKDLASAVAvGEAENAVRLMTIH 788
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 565 SAKGLEFPRVFIVGV-----------------EEGI------------FPSgMSFDEGR-------LQEERRLAYVGITR 608
Cdd:TIGR02785 789 KSKGLEFPVVFVLGMgkqfnkqdlnssylldrQLGLgikyidpqerlsYPS-LPKVAIKqkmkrelLSEEMRVLYVALTR 867
|
....*
gi 493294436 609 AKKKL 613
Cdd:TIGR02785 868 AKEKL 872
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
12-615 |
3.36e-29 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 124.80 E-value: 3.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 12 DKQREAvAAPIGNYLVLAGAGSGKTRVLTHRIAWLIgVENVPESNILAVTFTNKAAAEMRHRIEYTLSQ---SGD----- 83
Cdd:TIGR02784 1 ARQAQA-ADPAASAWVSANAGSGKTHVLTQRVIRLL-LAGTEPSKILCLTYTKAAAAEMQNRVFKRLGEwavLDDadlra 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 84 ------------------NRLF--------GMWVGTFHSIANRLLRSHYLDADLPQDFQIMD------------------ 119
Cdd:TIGR02784 79 rlealegkrpdaaklaeaRRLFaraletpgGLKIQTIHAFCEALLHQFPLEANVAGHFSVIDdraaatlleearrallag 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 120 --TEDQQRLLKRLLKLHNIDEK------------------------------------HFPPK----------------- 144
Cdd:TIGR02784 159 paAPDDALADALATVLEAAGETgleallaeivarrdalmafldeaggegaearlrralGLAPGdtaedlleavwplpglp 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 145 HVAW-YINAQKDKGKRAKDIDHH-------------------------NDPNEKK------------------------- 173
Cdd:TIGR02784 239 RLALaLIAALLKSGGGSKDAAAAlsqlreaaaepdpvarldlllgaflTSKGEPKsasfvikkaiqkslpdlaealedaa 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 174 -----LVEIYQIYQDACDRAGLLDFAELLIRAYELFK-------------------TKPTILQRYQQRFQQ----ILIDE 225
Cdd:TIGR02784 319 srveaLRERLRALRMAQRTLAALRLAARLLQRYARLKkarglldfndliertvallARPGAGAWVHYKLDRgidhILVDE 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 226 FQDTNNIQYDLIRLLAGD--VGK---------VMIVGDDDQSIYGWRGAQVEN--------IQRFLNDYDNAQTIRLEQN 286
Cdd:TIGR02784 399 AQDTSPEQWDIIQALAEEffSGEgarsgvertIFAVGDEKQSIYSFQGADPERfaeerrefSRKVRAVGRKFEDLSLNYS 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 287 YRSTGNILSCANELIANNDNRLG----------------------------------KNLWTDSGDGEPVDiyCAFNELd 332
Cdd:TIGR02784 479 FRSTPDVLAAVDLVFADPENARGlsadsdapvheafrddlpgrvdlwdliskeegeePEDWTDPVDELGER--APEVRL- 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 333 eARFVASQIKQWKeDEGDLAECA----------VLYRSNSQsrvIEEALIQA----NIPyrIYGGMRFFERQEI--KDAL 396
Cdd:TIGR02784 556 -AERIAAEIRAWL-DRGTPIPGRgravrpgdilVLVRKRDA---FFSALIRAlkrrGIP--VAGADRLKLTSHIavKDLM 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 397 AYLRLIANRQDDAAFERVINTPTRGIGDRTLDTLRQITRGRqiTLWQAIQvavqeeqlsgRATSSLLRFVELINALDQET 476
Cdd:TIGR02784 629 ALGRFVLQPEDDLSLAALLKSPLFGLDEDDLFRLAAGRSGG--SLWAALR----------RREAEFAATLAVLRDWLSLA 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 477 EQMSLAEqtdfvikksgLYEMYKQEKGEK-------GEVRIENLEELVTATKQFvkpdEAEELTDLTAFLthASLEAGEA 549
Cdd:TIGR02784 697 DFLTPFE----------FYARLLGRDGGRrkllarlGAEAEDILDEFLSQALAY----ERTGLPGLQAFL--SWLEADDP 760
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 550 ----QASQHEDYVELMTLHSAKGLEFPRVFIV------------------GVEEGIFP---SGMSFD------------E 592
Cdd:TIGR02784 761 eikrEMDQARDEVRVMTVHGAKGLEAPVVFLVdtgskpfasqraplllatGGSGGKAPlwrPASAFDpslsaaarerlkE 840
|
890 900
....*....|....*....|...
gi 493294436 593 GRLQEERRLAYVGITRAKKKLTI 615
Cdd:TIGR02784 841 RAEDEYRRLLYVAMTRAEDRLIV 863
|
|
| AddB |
COG3857 |
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair]; |
174-642 |
4.13e-29 |
|
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
Pssm-ID: 443066 [Multi-domain] Cd Length: 1019 Bit Score: 124.47 E-value: 4.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 174 LVEIYQIYQDA-----CDRAGLLDFAELLIRAYELFKTKptilqryqqrfqQILIDEFQDTNNIQYDLIRLLAGDVGKVM 248
Cdd:COG3857 148 LALIYEAYEEKlagryIDSEDLLRLLAEKLEKSEFLEGA------------EIYIDGFTDFTPQELELLEALLKKAKEVT 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 249 IVGDDDQSIYGWRGAQVENIQRFlndYDNAQTIRLEQNYRSTGNILSCANELIAnndnrlgknlWTDSGDGEPVDIYCAF 328
Cdd:COG3857 216 ITLTLDPDELDLFSATGETYERL---LELAKENGVEVEFKKSPELAHLERNLFA----------YPPEEEPEGIEIIEAA 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 329 NELDEARFVASQIKQWKEDEG-DLAECAVLYRS-NSQSRVIEEALIQANIPYRIYGGMRFFERQEIKDALAYLRLIANRQ 406
Cdd:COG3857 283 NRRAEVEAVAREIRRLVREEGyRYRDIAVVVRDlEAYAPLIERVFAEYGIPYFIDEKRPLSHHPLVELILSLLELVRSNF 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 407 DDAAFERVINTP-TRGIGDRTLDTLRQITRGRQI--------TLWQAIQVAVQEEQLSGRATSSLLRFVELINALDQETE 477
Cdd:COG3857 363 RYEDVFRLLKTGlLRPLSREEIDRLENYVLAYGIrgrrwlerYLEEEEELTDEEEEDLERLNELRDRLLEPLLPLRERLK 442
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 478 QM-SLAEQTDFV---IKKSGLYEMYKQEKGEKGEVRIENLEELVTATKQFVK---------PDEAEELTDLTAFLTHASL 544
Cdd:COG3857 443 KAkTVREWAEALyefLEELGVPEKLEEWREAEEAGDLEEAREHEQAWNALIElldelvevlGDEKLSLEEFLRILESGLE 522
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 545 EAGEAQASQHEDYVELMTLHSAKGLEFPRVFIVGVEEGIFPSGMSFD----------------------EGRLQEERRLA 602
Cdd:COG3857 523 ELTFGLIPPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFPARPREDgllsdeererlnelglelpptsRERLLEERFLF 602
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 493294436 603 YVGITRAKKKLTISYAesRRLYGKEERhVPSRFIAELPEE 642
Cdd:COG3857 603 YRALTRASERLYLSYP--LADEEGKAL-LPSPLIDRLREL 639
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
289-617 |
5.43e-29 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 112.71 E-value: 5.43e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 289 STGNILSCANELIANNDNRLGKNLWTDSGDGEPVDIYCAFNELDEARFVASQIKQWKEDEG-DLAECAVLYRSNSQSRVI 367
Cdd:cd18807 1 STKNILDAANSLIKQNKNRPKKPLKAGNKSGGPVELLLAKDEADEAKAIADEIKRLIESGPvQYSDIAILVRTNRQARVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 368 EEALIqanipyriyggmrfferqeikdalaylrlianrqddaafervintptrgigdrtldtlrqitrgrqitlwqaiqv 447
Cdd:cd18807 81 EEALR--------------------------------------------------------------------------- 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 448 avqeeqlsgratssllrfvelinaldqeteqmslaeqtdfvikksglyemykqekgekgevrienleelvtatkqfvkpd 527
Cdd:cd18807 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 528 eaeeltdltaflthasleageaqasqhedyVELMTLHSAKGLEFPRVFIVGVEEGIFPSGMSF-----DEGRLQEERRLA 602
Cdd:cd18807 86 ------------------------------VTLMTIHASKGLEFPVVFIVGLGEGFIPSDASYhaakeDEERLEEERRLL 135
|
330
....*....|....*
gi 493294436 603 YVGITRAKKKLTISY 617
Cdd:cd18807 136 YVALTRAKKELYLVG 150
|
|
| recB |
TIGR00609 |
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
23-620 |
2.84e-27 |
|
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 118.69 E-value: 2.84e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 23 GNYLVLAGAGSGKTrvltHRIAWLI-------GVENVPEsnILAVTFTNKAAAEMRHRI--------------------- 74
Cdd:TIGR00609 10 GTFLIEASAGTGKT----FTIAQLYlrlllegGPLTVEE--ILVVTFTNAATEELKTRIrgrihqalralkaaltsqelp 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 75 EYTLSQSGDNRLFG--------------MWVGTFHSIANRLLRSHYLDADL---------PQDFQIMDTED--------- 122
Cdd:TIGR00609 84 EPLKEAIQDEKVKQaitrlrnalatmdeAAIYTIHGFCQRMLEQHAFESDEifdveliedESLLLAEITKDfwrrnfynl 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 123 -QQRLLKRLLKLHNIDEKH--------------FPPK----------HVAWYINAQKDKGKRAKDIDHHNDPNE------ 171
Cdd:TIGR00609 164 pFDIAQIVLKTKKSPQAVLtqiladlllqsylaFPSPpldleqlikwHEQIYKDLDKLDHAVFEEIDKLNAERNnlfclk 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 172 -----KKLVEIYQIYQDACDRAGLLDFAELLIRAYELFKTK--PTILQRYQQRFQQILIDEFQDTNNIQYDLIRLL--AG 242
Cdd:TIGR00609 244 drvflTLLKEVQEELKKEKKRRREIGFDDLLSRLETALKSAegEKLAQAIREQYPIALIDEFQDTDPQQYRIFSKLfiAQ 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 243 DVGKVMIVGDDDQSIYGWRGAQVENIQRFLNDYDNAQTirLEQNYRSTGNILSCANELIANNDNR-LGKNLWTDSG---- 317
Cdd:TIGR00609 324 KETSLFLIGDPKQAIYSFRGADIFTYLQAKSKADARYT--LGTNWRSTPALVGSLNKLFSLISNPfLEKPIFIPVLahqk 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 318 ---------DGEPVDIYCAFNELDE----------ARFVASQIKQW--KEDEGDLAEC-------------AVLYRSNSQ 363
Cdd:TIGR00609 402 nskgsfvinGQEQPPIHFFTTEVESegvddyrqtiAQKCAREIALWlaSAALGLANFIatfggrplragdiAVLVRGRKE 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 364 SRVIEEALIQANIPyRIYGGMR--FFERQEIKDALAYLRLIANRQDDAafervintptrgigdrtldTLRQITRGRQITL 441
Cdd:TIGR00609 482 ANQIRKALKKAQIP-SVYLSDKssVFATEEAQELLALLEALLEPENEG-------------------TLRAALASSIFGL 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 442 -WQAIQVAVQEEQLsgratssLLRFVELINALDQETEQMSLAEQTDFVIKKSGLYE-MYKQEKGEKGEVRIENLEELVta 519
Cdd:TIGR00609 542 sALELETLNQDEIT-------WERVVEKFREYHDIWRKIGVLAMFQRLMLEKGIGErLLSQPGGERILTNLLHLAELL-- 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 520 TKQFVKPDEAEELtdLTAFLTHASLE-AGEAQASQHE---DYVELMTLHSAKGLEFPRV---FIVGVEEGIFPSGMSFDE 592
Cdd:TIGR00609 613 QEAAHQERNKLSL--LRWLEDQISNEeEEEEEIIRLEsdaELVKIVTIHKSKGLEYPIVflpFITDAKKSNFASLHDQHS 690
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 493294436 593 G--------------------RLQEERRLAYVGITRAKKKLTISYAES 620
Cdd:TIGR00609 691 HeyqlydfnqseenqklarveRLAEDLRLLYVALTRAKKQLFIGIAPL 738
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
26-287 |
5.44e-22 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 91.78 E-value: 5.44e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 26 LVLAGAGSGKTRVLTHRIAWLIGVENVPESNILAVTFTNKAAAEMRHrieytlsqsgdnrlfgmwvgtfhsianrllrsh 105
Cdd:cd17914 3 LIQGPPGTGKTRVLVKIVAALMQNKNGEPGRILLVTPTNKAAAQLDN--------------------------------- 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 106 yldadlpqdfqimdtedqqrllkrllklhnidekhfppkhvawyinaqkdkgkrakdidhhndpnekklveiyqiyqdac 185
Cdd:cd17914 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 186 draglldfaellirayelfktkptilqryqqrfqqILIDEFQDTNNIQYDLIRLLAGDVGKVMIVGDDDQSIYGWRGAQV 265
Cdd:cd17914 50 -----------------------------------ILVDEAAQILEPETSRLIDLALDQGRVILVGDHDQLGPVWRGAVL 94
|
250 260
....*....|....*....|....*..
gi 493294436 266 EN-----IQRFLNDYDNAQTIRLEQNY 287
Cdd:cd17914 95 AKicneqSLFTRLVRLGVSLIRLQVQY 121
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
29-615 |
5.37e-16 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 82.33 E-value: 5.37e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 29 AGAGSGKTRVLTHR-IAWLIGVENVPEsnILAVTFTNKAAAEMRHRI---------------------EYTLSQSG--DN 84
Cdd:PRK13909 5 ASAGSGKTFALSVRfLALLFKGANPSE--ILALTFTKKAANEMKERIidtllnlekekeeselneleeKLGLSKEEllNK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 85 RLFGMW--------VGTFHSIANRLLRSHYLDADLPQDFQI----------------------------MDTEDQQRLLK 128
Cdd:PRK13909 83 RDKVYQeflnselkISTIDAFFQKILRKFCLNLGLSPDFSIkedtkeelnekflsalskeellellafiKQCESKKNNSF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 129 ----RLLKLHNIDEKHFPPKHvaWYINAQKDKG-KRAKDIDHHNDPNE-------------------------------- 171
Cdd:PRK13909 163 fellEKLYEKNNELKLFEKAK--NPIEFDEEKFlEELRSLKQQIQSIEtasknakkafkkedfeellnssktwlekesey 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 172 ----------------------------------KKLVEIYQIYQDACDRA----GLLDFAELLIRAYELFKT----KPT 209
Cdd:PRK13909 241 ryfkklyneeldaefeelknalkryydakenyklSKLFKLLQLYKEAKNELnkkkNALDFDDISKKVYELLGEeeidKDF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 210 ILQRYQQRFQQILIDEFQDTNNIQYDLIR-----LLAG----DVGKVMIVGDDDQSIYGWRGAQVENIQRFLNDYdNAQT 280
Cdd:PRK13909 321 LYFRLDSKISHILIDEFQDTSVLQYKILLplideIKSGegqkKFRSFFYVGDVKQSIYRFRGGKKELFDKVSKDF-KQKV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 281 IRLEQNYRSTGNILSCANELIANNDNRLGKNLWTDSGDGEPVDIYCAFNELDE-ARFVASQIKQWKEDEGDLAECAVLYR 359
Cdd:PRK13909 400 DNLDTNYRSAPLIVDFVNEVFKKKYKNYKTQYAEQHKSGGYVEVVEVADESEElLEQLLQEIQFLLEKGIDPDDIAILCW 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 360 SNSQSRVIEEAL-IQANIPYRIYGGMRFFERQEIK---DALAYLrLIANRQDDAAFERVINTPtrgigdrtLDTLRQITR 435
Cdd:PRK13909 480 TNDDALEIKEFLqEQFGIKAVTESSAKLINQPEVKaliEALKYC-LFGEEIYKHNVLKLLGKE--------PDKIPSFLP 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 436 GRQiTLWQAIQVAVQEEQLSGratSSLLRFVELInaldqeteqmslaeqtdfvikksglyemykqekgekgeVRIENLEE 515
Cdd:PRK13909 551 KEE-SVAEFVKKLIEELKLYD---ENLLKFLELA--------------------------------------SGYEDIEE 588
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 516 LVTATKQFVKPDEAEELtdltaflthasleageaqasqheDYVELMTLHSAKGLEFPRVfIV------------------ 577
Cdd:PRK13909 589 FLFKLEPCDKEIASEES-----------------------KGVQIMTVHKSKGLEFEHV-IVcdrlgkpnsdssnllfey 644
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 493294436 578 -GVEEGIFPSGMS----FDEG-----------RLQEERRLAYVGITRAKKKLTI 615
Cdd:PRK13909 645 dGIELWQIYYRIKgrenFDKDyaralekekalKYEEEINVLYVAFTRAKNSLIV 698
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
10-312 |
6.45e-16 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 81.92 E-value: 6.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 10 LNDKQREAVAAPIGNYLVLAGAGSGKTRVLTHRIAWLI-GVENVPEsNILAVTFTNKAAAEMRHRIEYTLsqsGDNRLfg 88
Cdd:PRK11054 197 LNPSQARAVVNGEDSLLVLAGAGSGKTSVLVARAGWLLaRGQAQPE-QILLLAFGRQAAEEMDERIRERL---GTEDI-- 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 89 mWVGTFHSIANRLLRSH----------YLDADLPQDFQIMD-------------------TEDQQRLLKRLLKLHNidek 139
Cdd:PRK11054 271 -TARTFHALALHIIQQGskkvpvisklENDSKARHALLIAEwrkqcsekkaqakgwrqwlTEELQWDVPEGNFWDD---- 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 140 hfpPKHVAWYIN--------AQKDKGKRAKDIDHHNDPN------EKKLVE-IYQIYQDACDRAGLLDFAELLIRAYELF 204
Cdd:PRK11054 346 ---EKLQRRLASrlerwvslMRMHGGSQAEMIAQAPEEVrdlfqkRLKLMApLLKAWKKALKAENAVDFSGLIHQAVNYL 422
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 205 KTKptilqRYQQRFQQILIDEFQDtnnIQYDLIRLLAGDVGK-----VMIVGDDDQSIYGWRGAQVENIQRFLNDYDNAQ 279
Cdd:PRK11054 423 EKG-----RFISPWKHILVDEFQD---ISPQRAALLAALRKQnsqttLFAVGDDWQAIYRFSGADLSLTTAFHERFGEGD 494
|
330 340 350
....*....|....*....|....*....|...
gi 493294436 280 TIRLEQNYRSTGNILSCANELIANNDNRLGKNL 312
Cdd:PRK11054 495 RCHLDTTYRFNSRIGEVANRFIQQNPHQLKKPL 527
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
12-401 |
5.40e-15 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 78.72 E-value: 5.40e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 12 DKQREAVAAPI--GNYLVLAGAGSGKTRVLTHRIAWLigVENVPESNILAVTFTNKAAAEMRHRIEYTLSQSGDNRLFGm 89
Cdd:COG3972 161 DLQQERIARSIpdGPQRIRGVAGSGKTVLLAAKAAYL--ALKHPGWRILVTCFNRSLADHLRDLIPRFLRRFSNGEPED- 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 90 W--VGTFHSIANRLLRSHyldadlpqdfqimdtedqqrllkrllklhnidekhfppkhvawyinaqkdkGKRAKDIDHHN 167
Cdd:COG3972 238 NvkLIVFHAWGGKLLKQY---------------------------------------------------GIPPLTFSQPN 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 168 DPnekklveiyqiYQDACDRaglldfaelLIRAYELFKTKPtilqryqqRFQQILIDEFQDTNNIQYDLIR-LLAGDVGK 246
Cdd:COG3972 267 EA-----------FDEACKA---------LLEAIQGEIIPP--------IYDAILIDEAQDFEPEFLRLLYqLLKPPKKR 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 247 VMIVGDDDQSIYG---WRGAQVENIQRflndydnaQTIRLEQNYRSTGNILSCANEL---------------------IA 302
Cdd:COG3972 319 LIWAYDEAQNIYGrkiPSAGGIPAGIG--------RDTILKKNYRNTRPILTFAHAFgmgllrppgllqgdaedyeveRP 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 303 NNDNRLGKNLWTDSGDGEPVDIYCAFNELDEARFVASQIKQWKEDEG-DLAECAVLYRSNSQSR----VIEEALIQANIP 377
Cdd:COG3972 391 GDKVTLIRPPEPAGRKGPLPEFKKYDDRAEELEAIAEEIKKNLRDEGlRPSDIAVIYLGNNEAKelgdRLAAALERQGID 470
|
410 420
....*....|....*....|....
gi 493294436 378 YRIYGGMRFFERQEIKDALAYLRL 401
Cdd:COG3972 471 SYIAGARSDPNFFWKDGGVTISTI 494
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
14-74 |
1.04e-13 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 68.78 E-value: 1.04e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493294436 14 QREAV--AAPIGNYLVLAGAGSGKTRVLTHRIAWLIGVENVPESnILAVTFTNKAAAEMRHRI 74
Cdd:pfam13245 1 QREAVrtALPSKVVLLTGGPGTGKTTTIRHIVALLVALGGVSFP-ILLAAPTGRAAKRLSERT 62
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
196-359 |
1.22e-10 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 64.89 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 196 LLIRAYELFKTKPTilqryQQRFQQILIDEFQDTNNIQYDLIRLLAGDvGKVMIVGDDDQSIYGWRGAqvENIQRFLNDY 275
Cdd:COG3973 453 LLDELAELLGGPDR-----TWTYGHVVVDEAQDLSPMQWRVLKRRFPS-ASFTIVGDLAQAIHPYRGA--ESWEEVLEPL 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 276 --DNAQTIRLEQNYRSTGNILSCANELIANNDNRLGKNLWTDSGDGEPVDIYCAfNELDEARFVASQIKQWKEDEG---- 349
Cdd:COG3973 525 ggDRARLVELTKSYRSTAEIMEFANRVLRAAGPDLPPPESVRRHGEPPRVVRVP-SEAELAAAVVEAVRELLAEGEgtia 603
|
170
....*....|....
gi 493294436 350 ----DLAECAVLYR 359
Cdd:COG3973 604 vickTAREAEALYA 617
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
556-615 |
4.99e-10 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 56.68 E-value: 4.99e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 556 DYVELMTLHSAKGLEFPRVFIVGVEEGifpsgmsfdegrlQEERRLAYVGITRAKKKLTI 615
Cdd:cd18786 41 QLVGAITIDSSQGLTFDVVTLYLPTAN-------------SLTPRRLYVALTRARKRLVI 87
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
557-615 |
9.54e-10 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 54.50 E-value: 9.54e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 493294436 557 YVELMTLHSAKGLEFPRVFIVGVEEgifpsgmsFDEGRLQEERRLAYVGITRAKKKLTI 615
Cdd:pfam13538 1 LAYALTVHKAQGSEFPAVFLVDPDL--------TAHYHSMLRRRLLYTAVTRARKKLVL 51
|
|
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
172-609 |
1.75e-09 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 61.53 E-value: 1.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 172 KKLVEIYQIYQDACDRAGLLDFAELLIRAYELFKTK--PTILQRYQQRFQQILIDEFQDTNNIQYDLIRLLAG---DVGK 246
Cdd:PRK10876 330 RALAEIRETVAQEKRRRGELGFDDLLSRLDSALQSEggEALAAAIRTRYPVAMIDEFQDTDPQQYRIFRRIYRhqpETAL 409
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 247 VMIvGDDDQSIYGWRGAQVENIQRFLNDYDNAQTirLEQNYRSTGNILSCANELIANNDNRL-------------GKN-- 311
Cdd:PRK10876 410 LLI-GDPKQAIYAFRGADIFTYMKARSEVSAHYT--LDTNWRSAPGMVNSVNKLFSQTDDPFlfreipfipvkaaGKNqa 486
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 312 --------------LWTDSGDGEPVDIYCAFneldEARFVASQIKQW-----------KEDEGDLAECA----VLYRSNS 362
Cdd:PRK10876 487 lrfvvkgetqpamkFWLMEGEGVGVGDYQQT----MAQQCAAQIRDWlqagqrgeallMNGDDSRPVRAsditVLVRSRQ 562
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 363 QSRVIEEALIQANIPYriyggmrfferqeikdalAYLrliANRqdDAAFErvinTPtrgigdrtldtlrqitRGRQItLW 442
Cdd:PRK10876 563 EAALIRDALTLLAIPS------------------VYL---SNR--DSVFE----TL----------------EAQEM-LW 598
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 443 --QAIQVAVQEEQLSGRATSSLLRFVEL-INALDQ-ETEQMSLAEQTD--FVI-KKSGLYEMYKQEKGEKgevRI-ENLe 514
Cdd:PRK10876 599 llQAVLAPERERTLRSALATSMMGLDALdIDALNNdERAWDALVEEFDgyRQIwRKRGVLPMLRALMSAR---NIaENL- 674
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 515 eLVTAtkqfvkpdEAE-ELTD---LTAFLTHASLEAGEAQA-----SQH------------------EDYVELMTLHSAK 567
Cdd:PRK10876 675 -LATA--------GGErRLTDilhIGELLQEASSQLDSEHAlvrwlAQQilepdsqassqqlrlesdKHLVQIVTIHKSK 745
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493294436 568 GLEFPRV---FIVGV---EEGIFPSGMSF----------------DEGRLQEERRLAYVGITRA 609
Cdd:PRK10876 746 GLEYPLVwlpFITNFrvqDQAFYHDRHSFeavldlnaaeesvalaEEERLAEDLRLLYVALTRS 809
|
|
| SF1_C_RecD |
cd18809 |
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11. ... |
561-615 |
1.55e-07 |
|
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350196 [Multi-domain] Cd Length: 80 Bit Score: 49.10 E-value: 1.55e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 493294436 561 MTLHSAKGLEFPRVFIVgveegifpsgmsFDEGRLQEERRLAYVGITRAKKKLTI 615
Cdd:cd18809 36 MTIHKSQGSEFDRVIVV------------LPTSHPMLSRGLLYTALTRARKLLTL 78
|
|
| DEAD-like_helicase_N |
cd17912 |
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ... |
24-70 |
8.03e-07 |
|
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.
Pssm-ID: 350670 [Multi-domain] Cd Length: 81 Bit Score: 47.13 E-value: 8.03e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 493294436 24 NYLVLAGAGSGKTRVLTHRIAWLigveNVPESNILAVTFTNKAAAEM 70
Cdd:cd17912 1 NILHLGPTGSGKTLVAIQKIASA----MSSGKSVLVVTPTKLLAHEI 43
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
561-615 |
1.21e-05 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 48.43 E-value: 1.21e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 493294436 561 MTLHSAKGLEFPRVFIVGVEEgifPSGMSFdegrlqeeRRLAYVGITRAKKKLTI 615
Cdd:COG0507 445 ITVHKSQGSTFDRVILVLPSE---HSPLLS--------RELLYTALTRARELLTL 488
|
|
| Viral_helicase1 |
pfam01443 |
Viral (Superfamily 1) RNA helicase; Helicase activity for this family has been demonstrated ... |
507-615 |
4.66e-04 |
|
Viral (Superfamily 1) RNA helicase; Helicase activity for this family has been demonstrated and NTPase activity. This helicase has multiple roles at different stages of viral RNA replication, as dissected by mutational analysis.
Pssm-ID: 366646 [Multi-domain] Cd Length: 227 Bit Score: 42.37 E-value: 4.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 507 EVRIENLEELVTATKQFVKPDEAEELTDLTAFLTHAsleageaQASQHEDYVELMTLHSAKGLEFPRVFIVGVEEgifps 586
Cdd:pfam01443 132 PILSAKGFEVVVERSGEYKVDYDPNGVLVLVYLTFT-------QALKESLGVRVTTVHEVQGLTFDSVTLVLDTD----- 199
|
90 100
....*....|....*....|....*....
gi 493294436 587 gmsFDEGRLQEERRLAYVGITRAKKKLTI 615
Cdd:pfam01443 200 ---TDLLIISDSPEHLYVALTRHRKSLHI 225
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
507-615 |
2.69e-03 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 41.00 E-value: 2.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493294436 507 EVRIENLEELVTATKQFVKpDEAEELTDLTAFLTHASLEAGEAQASQHEDY---------------VELMTLHSAKGLEF 571
Cdd:COG3973 574 VVRVPSEAELAAAVVEAVR-ELLAEGEGTIAVICKTAREAEALYAALKAGLpvtliddeseeleagVVVLPAYLAKGLEF 652
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 493294436 572 PRVFIVgveegiFPSGMSFDEGRlqeERRLAYVGITRAKKKLTI 615
Cdd:COG3973 653 DAVVVV------DPDEIVYESPR---GRRLLYVALTRATHRLTV 687
|
|
| DEAD-like_helicase_N |
cd17912 |
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ... |
206-253 |
4.19e-03 |
|
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.
Pssm-ID: 350670 [Multi-domain] Cd Length: 81 Bit Score: 36.73 E-value: 4.19e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 493294436 206 TKPTILQRYqqrfqqILIDEFQDTNNIQY----DLIRLLAGDVGKVMIVGDD 253
Cdd:cd17912 36 TKLLAHEIL------IVIDEIQ*ILDPAAgwawATRALLGLKAEKVIGVGAT 81
|
|
| RecD |
COG0507 |
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ... |
10-71 |
8.77e-03 |
|
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440273 [Multi-domain] Cd Length: 514 Bit Score: 39.19 E-value: 8.77e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493294436 10 LNDKQREAV--AAPIGNYLVLAG-AGSGKTRVLtHRIAWLIGVENVpesNILAVTFTNKAAAEMR 71
Cdd:COG0507 125 LSDEQREAValALTTRRVSVLTGgAGTGKTTTL-RALLAALEALGL---RVALAAPTGKAAKRLS 185
|
|
| |
