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Conserved domains on  [gi|493356863|ref|WP_006313419|]
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MULTISPECIES: histidine utilization repressor [Agrobacterium]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11493457)

GntR family transcriptional regulator such as the histidine utilization repressor HutC, a repressor which binds to the hutP region in the histidine utilization (hut) operon

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 19-245 3.44e-131

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


:

Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 369.72  E-value: 3.44e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863   19 PLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGLMGVRNI 98
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863   99 ADEIKERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLMQDFTTLTPNA 178
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493356863  179 YLTAAAPISRTEQFIEAASPQPWECKLMAISRNEPCLLVRRRTWSSSRAVTSVRLLYPGSRYRLESQ 245
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGR 227
 
Name Accession Description Interval E-value
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 19-245 3.44e-131

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 369.72  E-value: 3.44e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863   19 PLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGLMGVRNI 98
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863   99 ADEIKERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLMQDFTTLTPNA 178
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493356863  179 YLTAAAPISRTEQFIEAASPQPWECKLMAISRNEPCLLVRRRTWSSSRAVTSVRLLYPGSRYRLESQ 245
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGR 227
PRK14999 PRK14999
histidine utilization repressor; Provisional
 9-243 5.40e-89

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 263.33  E-value: 5.40e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863   9 FPVSGDRSSLPLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKR 88
Cdd:PRK14999   2 YSSRSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  89 SAGLMGVRNIADEIKERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLM 168
Cdd:PRK14999  82 QSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLT 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493356863 169 QDFTTLTPNAYLTAAAPISRTEQFIEAASPQPWECKLMAISRNEPCLLVRRRTWSSSRAVTSVRLLYPGSRYRLE 243
Cdd:PRK14999 162 QDYRQTTPHAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQ 236
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
15-245 5.80e-76

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 229.75  E-value: 5.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  15 RSSLPLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGLMG 94
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  95 VRNIADEIKERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLMQDFTTL 174
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493356863 175 TPNAYLTAAA--PISRTEQFIEAASPQPWECKLMAISRNEPCLLVRRRTWSSS-RAVTSVRLLYPGSRYRLESQ 245
Cdd:COG2188  161 SLYELLEERYglRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADgRPVEYSRSYYRGDRYRFVVE 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 104-241 1.95e-32

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 115.39  E-value: 1.95e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  104 ERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLMQDFTTLTPNAYLTAA 183
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493356863  184 --APISRTEQFIEAASPQPWECKLMAISRNEPCLLVRRRTWSSS-RAVTSVRLLYPGSRYR 241
Cdd:pfam07702  81 ygLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDgRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 104-241 3.63e-30

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 109.69  E-value: 3.63e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863   104 ERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLMQDFTT---LTPNAYL 180
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGslyEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493356863   181 -TAAAPISRTEQFIEAASPQPWECKLMAISRNEPCLLVRR-RTWSSSRAVTSVRLLYPGSRYR 241
Cdd:smart00866  81 gLKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERvTYDDDGRPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-84 1.24e-24

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 92.90  E-value: 1.24e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493356863  19 PLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVA 84
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 19-245 3.44e-131

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 369.72  E-value: 3.44e-131
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863   19 PLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGLMGVRNI 98
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863   99 ADEIKERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLMQDFTTLTPNA 178
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 493356863  179 YLTAAAPISRTEQFIEAASPQPWECKLMAISRNEPCLLVRRRTWSSSRAVTSVRLLYPGSRYRLESQ 245
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGR 227
PRK14999 PRK14999
histidine utilization repressor; Provisional
 9-243 5.40e-89

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 263.33  E-value: 5.40e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863   9 FPVSGDRSSLPLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKR 88
Cdd:PRK14999   2 YSSRSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  89 SAGLMGVRNIADEIKERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLM 168
Cdd:PRK14999  82 QSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLT 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493356863 169 QDFTTLTPNAYLTAAAPISRTEQFIEAASPQPWECKLMAISRNEPCLLVRRRTWSSSRAVTSVRLLYPGSRYRLE 243
Cdd:PRK14999 162 QDYRQTTPHAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQ 236
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
15-245 5.80e-76

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 229.75  E-value: 5.80e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  15 RSSLPLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGLMG 94
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  95 VRNIADEIKERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLMQDFTTL 174
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493356863 175 TPNAYLTAAA--PISRTEQFIEAASPQPWECKLMAISRNEPCLLVRRRTWSSS-RAVTSVRLLYPGSRYRLESQ 245
Cdd:COG2188  161 SLYELLEERYglRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADgRPVEYSRSYYRGDRYRFVVE 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 104-241 1.95e-32

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 115.39  E-value: 1.95e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  104 ERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLMQDFTTLTPNAYLTAA 183
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493356863  184 --APISRTEQFIEAASPQPWECKLMAISRNEPCLLVRRRTWSSS-RAVTSVRLLYPGSRYR 241
Cdd:pfam07702  81 ygLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDgRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 104-241 3.63e-30

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 109.69  E-value: 3.63e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863   104 ERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLMQDFTT---LTPNAYL 180
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGslyEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493356863   181 -TAAAPISRTEQFIEAASPQPWECKLMAISRNEPCLLVRR-RTWSSSRAVTSVRLLYPGSRYR 241
Cdd:smart00866  81 gLKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERvTYDDDGRPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-84 1.24e-24

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 92.90  E-value: 1.24e-24
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493356863  19 PLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVA 84
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
15-102 6.46e-24

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 92.55  E-value: 6.46e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  15 RSSLPLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGLMG 94
Cdd:COG1725    6 DSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEER 85


                 ....*...
gi 493356863  95 VRNIADEI 102
Cdd:COG1725   86 REEFLEEA 93
PRK11402 PRK11402
transcriptional regulator PhoB;
16-166 4.41e-21

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 88.35  E-value: 4.41e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  16 SSLPLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGLMGV 95
Cdd:PRK11402   6 SHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTV 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493356863  96 RNIADEIKERGSTHRPSlILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDY 166
Cdd:PRK11402  86 SGFTDFGVSQGKATKEK-VIEQERVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDF 155
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 20-83 1.00e-18

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 77.27  E-value: 1.00e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493356863   20 LYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFV 83
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 15-90 3.90e-18

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 82.95  E-value: 3.90e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493356863  15 RSSLPLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSA 90
Cdd:COG1167    8 DSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAP 83
PRK09764 PRK09764
GntR family transcriptional regulator;
16-220 7.89e-16

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 74.09  E-value: 7.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  16 SSLPLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGLMGV 95
Cdd:PRK09764   2 GHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  96 RNIADEIKERG-STHRPSLILaqtEVCGPD--LATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVNAEIAPDYLMQDFT 172
Cdd:PRK09764  82 TSFDEKLSDRHvDTHSEVLIF---EVIPADdfLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVME 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 493356863 173 TlTPNAYL--TAAAPISRTEQFIEAASPQPWECKLMAISRNEPCLLVRRR 220
Cdd:PRK09764 159 N-SKYHFIeeVKKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSR 207
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
20-92 1.31e-15

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 73.43  E-value: 1.31e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493356863  20 LYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGL 92
Cdd:COG2186    8 LAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALL 80
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
24-83 1.44e-15

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 68.76  E-value: 1.44e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863    24 VKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFV 83
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 23-233 3.32e-10

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 58.25  E-value: 3.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863  23 RVKEQIKEKIASGQWLtnhriPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGLMGVRNIADEI 102
Cdd:PRK10079  20 KLEQELRQHYRCGDYL-----PAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLNAQARFSQNL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493356863 103 KERGSTHRPSLILAQTEVCGPDLATALEIGVGTKVFHSIIVHHEDDVPIQLEDRFVnAEIAPDYLMQDFTTLTPNAYLT- 181
Cdd:PRK10079  95 LDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYF-ADLTWWPTLQRFDSGSLHDFLRe 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493356863 182 -AAAPISRTEQFIEAASPQPWECKLMAISRNEPCLLVR---RRTWSSSRAVTSVRL 233
Cdd:PRK10079 174 qLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCVRtlnHRDGESSPAEYSVSL 229
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
10-85 5.93e-10

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 57.62  E-value: 5.93e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493356863  10 PVSGDRSSLPLYERVKEQIKEKIASGQWLTNHRIpSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAP 85
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 19-92 1.34e-06

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 47.84  E-value: 1.34e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493356863  19 PLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFVAPKKRSAGL 92
Cdd:PRK09990   7 PIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDA 80
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 18-83 2.80e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 43.99  E-value: 2.80e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493356863  18 LPLYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFV 83
Cdd:PRK10421   1 RRLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
36-78 3.23e-05

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 40.28  E-value: 3.23e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 493356863    36 QWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQG 78
Cdd:smart00420   7 ELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
36-79 7.54e-05

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 39.55  E-value: 7.54e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 493356863   36 QWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGR 79
Cdd:pfam08220   7 ELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGG 50
PRK10225 PRK10225
Uxu operon transcriptional regulator;
21-83 1.71e-04

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 41.93  E-value: 1.71e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 493356863  21 YERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFV 83
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
PRK11523 PRK11523
transcriptional regulator ExuR;
20-83 3.25e-03

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 37.90  E-value: 3.25e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 493356863  20 LYERVKEQIKEKIASGQWLTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGRGSFV 83
Cdd:PRK11523   9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
COG3177 COG3177
Fic family protein [Transcription];
20-79 4.68e-03

Fic family protein [Transcription];


Pssm-ID: 442410 [Multi-domain]  Cd Length: 316  Bit Score: 37.74  E-value: 4.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493356863  20 LYERVKEQIKEKIASGQW-----LTNHRIPSENEMVDMLGVSRMTANRALRELATEGVIVRVQGR 79
Cdd:COG3177  247 LLERLLELARGRLNERQRkllelLFENPVLTASELAELLGVSRRTARRDLKDLVELGILEKVGGG 311
HTH_CRP smart00419
helix_turn_helix, cAMP Regulatory protein;
35-79 4.98e-03

helix_turn_helix, cAMP Regulatory protein;


Pssm-ID: 128696 [Multi-domain]  Cd Length: 48  Bit Score: 34.34  E-value: 4.98e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 493356863    35 GQWLTNHRIPSEnEMVDMLGVSRMTANRALRELATEGVIVRVQGR 79
Cdd:smart00419   1 EGIRVRLPLTRQ-EIAELLGLTRETVSRTLKRLEKEGLISREGGR 44
HTH_Crp_2 pfam13545
Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain ...
 48-75 7.19e-03

Crp-like helix-turn-helix domain; This family represents a crp-like helix-turn-helix domain that is likely to bind DNA.


Pssm-ID: 463917 [Multi-domain]  Cd Length: 68  Bit Score: 34.35  E-value: 7.19e-03
                          10        20
                  ....*....|....*....|....*...
gi 493356863   48 EMVDMLGVSRMTANRALRELATEGVIVR 75
Cdd:pfam13545  27 DLADLLGTTRETVSRVLSELRREGLIER 54
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 14-79 7.39e-03

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 36.50  E-value: 7.39e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493356863  14 DRSSLPLYERVKEQIKEKIASGQWLTNHRIPSEnEMVDMLGVSRMTANRALRELATEGVIVRVQGR 79
Cdd:COG0664  130 SLAFLSAEERLARFLLELADRLDGRIDLPLTQE-EIASYLGLTRETVSRILKKLEKEGLIELERGR 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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