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Conserved domains on  [gi|493449412|ref|WP_006404716|]
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ATP phosphoribosyltransferase regulatory subunit [Burkholderia multivorans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK12421 super family cl30587
ATP phosphoribosyltransferase regulatory subunit; Provisional
 3-381 2.57e-157

ATP phosphoribosyltransferase regulatory subunit; Provisional


The actual alignment was detected with superfamily member PRK12421:

Pssm-ID: 237098  Cd Length: 392  Bit Score: 447.88  E-value: 2.57e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   3 TWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLSGRTLGLRADIT 82
Cdd:PRK12421   6 RWLLPDGVADVLPEEAQKIERLRRRLLDLFASRGYQLVMPPLIEYLESLLTGAGQDLKLQTFKLIDQLSGRLMGVRADIT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  83 PQVARIDAHLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCH 162
Cdd:PRK12421  86 PQVARIDAHLLNREGVARLCYAGSVLHTLPQGLFGSRTPLQLGAELYGHAGIEADLEIIRLMLGLLRNAGVPALHLDLGH 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 163 AGVLAALLARDTQAAARGEALYDALSGKDVPLLNELTDDL--GADTRAALRALPHLYGDASVLDEARQRLP-ALPEIARA 239
Cdd:PRK12421 166 VGIFRRLAELAGLSPEEEEELFDLLQRKALPELAEVCQNLgvGSDLRRMFYALARLNGGLEALDRALSVLAlQDAAIRQA 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 240 LDDLAQLAAQAKGAE----VAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLRELAR 315
Cdd:PRK12421 246 LDELKTLAAHLKNRWpelpVSIDLAELRGYHYHTGLVFAAYIPGRGQALARGGRYDGIGEAFGRARPATGFSMDLKELLA 325

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493449412 316 ISPVEARGTAILAPWAQDDALRAAVAALRDAGEVVIQALPGHDhVLDEFACDRSLVERNGAWVVEP 381
Cdd:PRK12421 326 LQFLEEEAGAILAPWGDDPDLLAAIAELRQQGERVVQLLPGDD-GSSEPGCDHRLVLQDGQWQIEA 390
 
Name Accession Description Interval E-value
PRK12421 PRK12421
ATP phosphoribosyltransferase regulatory subunit; Provisional
 3-381 2.57e-157

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237098  Cd Length: 392  Bit Score: 447.88  E-value: 2.57e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   3 TWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLSGRTLGLRADIT 82
Cdd:PRK12421   6 RWLLPDGVADVLPEEAQKIERLRRRLLDLFASRGYQLVMPPLIEYLESLLTGAGQDLKLQTFKLIDQLSGRLMGVRADIT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  83 PQVARIDAHLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCH 162
Cdd:PRK12421  86 PQVARIDAHLLNREGVARLCYAGSVLHTLPQGLFGSRTPLQLGAELYGHAGIEADLEIIRLMLGLLRNAGVPALHLDLGH 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 163 AGVLAALLARDTQAAARGEALYDALSGKDVPLLNELTDDL--GADTRAALRALPHLYGDASVLDEARQRLP-ALPEIARA 239
Cdd:PRK12421 166 VGIFRRLAELAGLSPEEEEELFDLLQRKALPELAEVCQNLgvGSDLRRMFYALARLNGGLEALDRALSVLAlQDAAIRQA 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 240 LDDLAQLAAQAKGAE----VAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLRELAR 315
Cdd:PRK12421 246 LDELKTLAAHLKNRWpelpVSIDLAELRGYHYHTGLVFAAYIPGRGQALARGGRYDGIGEAFGRARPATGFSMDLKELLA 325

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493449412 316 ISPVEARGTAILAPWAQDDALRAAVAALRDAGEVVIQALPGHDhVLDEFACDRSLVERNGAWVVEP 381
Cdd:PRK12421 326 LQFLEEEAGAILAPWGDDPDLLAAIAELRQQGERVVQLLPGDD-GSSEPGCDHRLVLQDGQWQIEA 390
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 10-313 4.77e-137

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 393.10  E-value: 4.77e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   10 IADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRlRTFKLVDQlSGRTLGLRADITPQVARID 89
Cdd:pfam13393   2 IRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTGTGADLD-QTFKLVDQ-SGRLLGLRADITPQVARID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   90 AHLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAAL 169
Cdd:pfam13393  80 AHRLNRPGPLRLCYAGSVLRTRPKGLGRSREPLQVGAELIGHAGIEADAEIISLLLEALAAAGVPGVTLDLGHVGLVRAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  170 LARDTQAAARGEALYDALSGKDVPLLNELTDDLG--ADTRAALRALPHLYGDASVLDEARQRLPALPEIARALDDLAQLA 247
Cdd:pfam13393 160 LEAAGLSEALEEALRAALQRKDAAELAELAAEAGlpPALRRALLALPDLYGGPEVLDEARAALPGLPALQEALDELEALA 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  248 AQA----KGAEVAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLREL 313
Cdd:pfam13393 240 ALLealgDGVRLTFDLAELRGYEYYTGIVFAAYAPGVGEPLARGGRYDDLGAAFGRARPATGFSLDLEAL 309
HisZ COG3705
ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];
14-318 3.39e-126

ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];


Pssm-ID: 442919 [Multi-domain]  Cd Length: 312  Bit Score: 365.65  E-value: 3.39e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  14 LPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLsGRTLGLRADITPQVARIDAHLL 93
Cdd:COG3705    1 LPEEAARKEELRRRLLDVFRSWGYELVEPPLLEYLDSLLTGSGADLDLQTFKLVDQL-GRTLGLRPDMTPQVARIAATRL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  94 -NRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAALLAR 172
Cdd:COG3705   80 aNRPGPLRLCYAGNVFRTRPSGLGRSREFLQAGAELIGHAGLEADAEVIALALEALKAAGLEDFTLDLGHVGLFRALLEA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 173 DTQAAARGEALYDALSGKDVPLLNELTDDLG--ADTRAALRALPHLYGDASVLDEARQRLPALpEIARALDDLAQLAAQA 250
Cdd:COG3705  160 LGLSEEQREELRRALARKDAVELEELLAELGlsEELAEALLALPELYGGEEVLARARALLLDA-AIRAALDELEALAEAL 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493449412 251 K----GAEVAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLRELARISP 318
Cdd:COG3705  239 AargpDVRLTFDLSELRGYDYYTGIVFEAYAPGVGDPLARGGRYDGLLAAFGRARPATGFSLDLDRLLRALP 310
hisZ_biosyn_reg TIGR00443
ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA ...
 12-313 5.69e-91

ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA synthetase, found in Bacillus subtilis, Synechocystis sp., Aquifex aeolicus, and others, are in fact a regulatory subunit of ATP phosphoribosyltransferase, and usually encoded by a gene adjacent to that encoding the catalytic subunit. [Amino acid biosynthesis, Histidine family]


Pssm-ID: 273081 [Multi-domain]  Cd Length: 313  Bit Score: 276.03  E-value: 5.69e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   12 DVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLlTSGGADLRLRTFKLVDQLsGRTLGLRADITPQVAR-IDA 90
Cdd:TIGR00443   2 DLLPEEAARKEEIERQLQDVFRSWGYQEIITPTLEYLDTL-SAGSGILNEDLFKLFDQL-GRVLGLRPDMTAPIARlVST 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   91 HLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAALL 170
Cdd:TIGR00443  80 RLRDRPLPLRLCYAGNVFRTNESGGGRSREFTQAGVELIGAGGPAADAEVIALLIEALKALGLKDFKIELGHVGLVRALL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  171 ARDTQAAARGEALYDALSGKDVPLLNELTDDLGADT--RAALRALPHLYGDAS-VLDEARQrLPALPEIARALDDLAQ-- 245
Cdd:TIGR00443 160 EEAGLPEEAREALREALARKDLVALEELVAELGLSPevRERLLALPRLRGDGEeVLEEARA-LAGSETAEAALDELEAvl 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  246 --LAAQAKGAEVAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLREL 313
Cdd:TIGR00443 239 elLEARGVEEYISLDLGLVRGYHYYTGLIFEGYAPGLGAPLAGGGRYDELLGRFGRPLPATGFALNLERL 308
HisRS-like_core cd00773
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. ...
 34-310 2.61e-47

Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. This domain is also found at the C-terminus of eukaryotic GCN2 protein kinase and at the N-terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain.


Pssm-ID: 238396 [Multi-domain]  Cd Length: 261  Bit Score: 161.62  E-value: 2.61e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  34 SYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQlSGRTLGLRADITPQVARIDA-HLLNRQGVTRLCYAGHVMHTRP 112
Cdd:cd00773   18 RYGYEEIDTPVFEYTELFLRKSGDEVSKEMYRFKDK-GGRDLALRPDLTAPVARAVAeNLLSLPLPLKLYYIGPVFRYER 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 113 RGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAALlardtqaaargealydALSGKDV 192
Cdd:cd00773   97 PQKGRYREFYQVGVEIIGSDSPLADAEVIALAVEILEALGLKDFQIKINHRGILDGI----------------AGLLEDR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 193 PLLNE-LTDDLGADTRAALRALphlygdasvldearqrlpalpeiARALDDLAQLaaqakgAEVAIDLADLRGYAYHSGA 271
Cdd:cd00773  161 EEYIErLIDKLDKEALAHLEKL-----------------------LDYLEALGVD------IKYSIDLSLVRGLDYYTGI 211

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 493449412 272 MFTAYIDGVP--NAIARGGRYDH-VGQAYGRARPATGFSLDL 310
Cdd:cd00773  212 VFEAVADGLGaqGSIAGGGRYDGlLEEFGGEDVPAVGFAIGL 253
 
Name Accession Description Interval E-value
PRK12421 PRK12421
ATP phosphoribosyltransferase regulatory subunit; Provisional
 3-381 2.57e-157

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237098  Cd Length: 392  Bit Score: 447.88  E-value: 2.57e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   3 TWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLSGRTLGLRADIT 82
Cdd:PRK12421   6 RWLLPDGVADVLPEEAQKIERLRRRLLDLFASRGYQLVMPPLIEYLESLLTGAGQDLKLQTFKLIDQLSGRLMGVRADIT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  83 PQVARIDAHLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCH 162
Cdd:PRK12421  86 PQVARIDAHLLNREGVARLCYAGSVLHTLPQGLFGSRTPLQLGAELYGHAGIEADLEIIRLMLGLLRNAGVPALHLDLGH 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 163 AGVLAALLARDTQAAARGEALYDALSGKDVPLLNELTDDL--GADTRAALRALPHLYGDASVLDEARQRLP-ALPEIARA 239
Cdd:PRK12421 166 VGIFRRLAELAGLSPEEEEELFDLLQRKALPELAEVCQNLgvGSDLRRMFYALARLNGGLEALDRALSVLAlQDAAIRQA 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 240 LDDLAQLAAQAKGAE----VAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLRELAR 315
Cdd:PRK12421 246 LDELKTLAAHLKNRWpelpVSIDLAELRGYHYHTGLVFAAYIPGRGQALARGGRYDGIGEAFGRARPATGFSMDLKELLA 325

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 493449412 316 ISPVEARGTAILAPWAQDDALRAAVAALRDAGEVVIQALPGHDhVLDEFACDRSLVERNGAWVVEP 381
Cdd:PRK12421 326 LQFLEEEAGAILAPWGDDPDLLAAIAELRQQGERVVQLLPGDD-GSSEPGCDHRLVLQDGQWQIEA 390
hisZ PRK12292
ATP phosphoribosyltransferase regulatory subunit; Provisional
 2-382 3.09e-146

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 237043 [Multi-domain]  Cd Length: 391  Bit Score: 419.66  E-value: 3.09e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   2 STWLLPENIADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLSGRTLGLRADI 81
Cdd:PRK12292   1 MMWQLPEGIRDLLPEEARKIEEIRRRLLDLFRRWGYEEVITPTLEYLDTLLAGGGAILDLRTFKLVDQLSGRTLGLRPDM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  82 TPQVARIDAHLL-NRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDL 160
Cdd:PRK12292  81 TAQIARIAATRLaNRPGPLRLCYAGNVFRAQERGLGRSREFLQSGVELIGDAGLEADAEVILLLLEALKALGLPNFTLDL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 161 CHAGVLAALLARDTQAAARGEALYDALSGKDVPLLNELTDDLGADTRAALRALPHLYGDASVLDEARQRLPALPEiARAL 240
Cdd:PRK12292 161 GHVGLFRALLEAAGLSEELEEVLRRALANKDYVALEELVLDLSEELRDALLALPRLRGGREVLEEARKLLPSLPI-KRAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 241 DDLAQLAAQ----AKGAEVAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLD---LREL 313
Cdd:PRK12292 240 DELEALAEAlekyGYGIPLSLDLGLLRHLDYYTGIVFEGYVDGVGNPIASGGRYDDLLGRFGRARPATGFSLDldrLLEL 319

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493449412 314 ARISPVEARGTAILAPW-AQDDALRAAVAALRDAGEVVIQALPGHD-HVLDEFACDRSLVERNGAWVVEPR 382
Cdd:PRK12292 320 QLELPVEARKDLVIAPDsEALAAALAAAQELRKKGEIVVLALPGRNfEDAREYARDRQIVEADGEWQVEPL 390
tRNA-synt_His pfam13393
Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP ...
 10-313 4.77e-137

Histidyl-tRNA synthetase; This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.


Pssm-ID: 433170 [Multi-domain]  Cd Length: 309  Bit Score: 393.10  E-value: 4.77e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   10 IADVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRlRTFKLVDQlSGRTLGLRADITPQVARID 89
Cdd:pfam13393   2 IRDLLPPEARRIEELRRRLLDLFRSWGYELVMPPLLEYLDSLLTGTGADLD-QTFKLVDQ-SGRLLGLRADITPQVARID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   90 AHLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAAL 169
Cdd:pfam13393  80 AHRLNRPGPLRLCYAGSVLRTRPKGLGRSREPLQVGAELIGHAGIEADAEIISLLLEALAAAGVPGVTLDLGHVGLVRAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  170 LARDTQAAARGEALYDALSGKDVPLLNELTDDLG--ADTRAALRALPHLYGDASVLDEARQRLPALPEIARALDDLAQLA 247
Cdd:pfam13393 160 LEAAGLSEALEEALRAALQRKDAAELAELAAEAGlpPALRRALLALPDLYGGPEVLDEARAALPGLPALQEALDELEALA 239

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  248 AQA----KGAEVAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLREL 313
Cdd:pfam13393 240 ALLealgDGVRLTFDLAELRGYEYYTGIVFAAYAPGVGEPLARGGRYDDLGAAFGRARPATGFSLDLEAL 309
HisZ COG3705
ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];
14-318 3.39e-126

ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism];


Pssm-ID: 442919 [Multi-domain]  Cd Length: 312  Bit Score: 365.65  E-value: 3.39e-126
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  14 LPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLsGRTLGLRADITPQVARIDAHLL 93
Cdd:COG3705    1 LPEEAARKEELRRRLLDVFRSWGYELVEPPLLEYLDSLLTGSGADLDLQTFKLVDQL-GRTLGLRPDMTPQVARIAATRL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  94 -NRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAALLAR 172
Cdd:COG3705   80 aNRPGPLRLCYAGNVFRTRPSGLGRSREFLQAGAELIGHAGLEADAEVIALALEALKAAGLEDFTLDLGHVGLFRALLEA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 173 DTQAAARGEALYDALSGKDVPLLNELTDDLG--ADTRAALRALPHLYGDASVLDEARQRLPALpEIARALDDLAQLAAQA 250
Cdd:COG3705  160 LGLSEEQREELRRALARKDAVELEELLAELGlsEELAEALLALPELYGGEEVLARARALLLDA-AIRAALDELEALAEAL 238

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 493449412 251 K----GAEVAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLRELARISP 318
Cdd:COG3705  239 AargpDVRLTFDLSELRGYDYYTGIVFEAYAPGVGDPLARGGRYDGLLAAFGRARPATGFSLDLDRLLRALP 310
hisZ_biosyn_reg TIGR00443
ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA ...
 12-313 5.69e-91

ATP phosphoribosyltransferase, regulatory subunit; Apparant second copies of histidyl-tRNA synthetase, found in Bacillus subtilis, Synechocystis sp., Aquifex aeolicus, and others, are in fact a regulatory subunit of ATP phosphoribosyltransferase, and usually encoded by a gene adjacent to that encoding the catalytic subunit. [Amino acid biosynthesis, Histidine family]


Pssm-ID: 273081 [Multi-domain]  Cd Length: 313  Bit Score: 276.03  E-value: 5.69e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   12 DVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLlTSGGADLRLRTFKLVDQLsGRTLGLRADITPQVAR-IDA 90
Cdd:TIGR00443   2 DLLPEEAARKEEIERQLQDVFRSWGYQEIITPTLEYLDTL-SAGSGILNEDLFKLFDQL-GRVLGLRPDMTAPIARlVST 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412   91 HLLNRQGVTRLCYAGHVMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAALL 170
Cdd:TIGR00443  80 RLRDRPLPLRLCYAGNVFRTNESGGGRSREFTQAGVELIGAGGPAADAEVIALLIEALKALGLKDFKIELGHVGLVRALL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  171 ARDTQAAARGEALYDALSGKDVPLLNELTDDLGADT--RAALRALPHLYGDAS-VLDEARQrLPALPEIARALDDLAQ-- 245
Cdd:TIGR00443 160 EEAGLPEEAREALREALARKDLVALEELVAELGLSPevRERLLALPRLRGDGEeVLEEARA-LAGSETAEAALDELEAvl 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  246 --LAAQAKGAEVAIDLADLRGYAYHSGAMFTAYIDGVPNAIARGGRYDHVGQAYGRARPATGFSLDLREL 313
Cdd:TIGR00443 239 elLEARGVEEYISLDLGLVRGYHYYTGLIFEGYAPGLGAPLAGGGRYDELLGRFGRPLPATGFALNLERL 308
HisRS-like_core cd00773
Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. ...
 34-310 2.61e-47

Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. This domain is also found at the C-terminus of eukaryotic GCN2 protein kinase and at the N-terminus of the ATP phosphoribosyltransferase accessory subunit, HisZ. HisZ along with HisG catalyze the first reaction in histidine biosynthesis. HisZ is found only in a subset of bacteria and differs from HisRS in lacking a C-terminal anti-codon binding domain.


Pssm-ID: 238396 [Multi-domain]  Cd Length: 261  Bit Score: 161.62  E-value: 2.61e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  34 SYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQlSGRTLGLRADITPQVARIDA-HLLNRQGVTRLCYAGHVMHTRP 112
Cdd:cd00773   18 RYGYEEIDTPVFEYTELFLRKSGDEVSKEMYRFKDK-GGRDLALRPDLTAPVARAVAeNLLSLPLPLKLYYIGPVFRYER 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 113 RGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAALlardtqaaargealydALSGKDV 192
Cdd:cd00773   97 PQKGRYREFYQVGVEIIGSDSPLADAEVIALAVEILEALGLKDFQIKINHRGILDGI----------------AGLLEDR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 193 PLLNE-LTDDLGADTRAALRALphlygdasvldearqrlpalpeiARALDDLAQLaaqakgAEVAIDLADLRGYAYHSGA 271
Cdd:cd00773  161 EEYIErLIDKLDKEALAHLEKL-----------------------LDYLEALGVD------IKYSIDLSLVRGLDYYTGI 211

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 493449412 272 MFTAYIDGVP--NAIARGGRYDH-VGQAYGRARPATGFSLDL 310
Cdd:cd00773  212 VFEAVADGLGaqGSIAGGGRYDGlLEEFGGEDVPAVGFAIGL 253
HisS COG0124
Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA ...
 12-327 6.16e-32

Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Histidyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439894 [Multi-domain]  Cd Length: 422  Bit Score: 124.85  E-value: 6.16e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  12 DVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRLR-TFKLVDQlSGRTLGLRADITPQVARIDA 90
Cdd:COG0124   12 DILPEESAKWQYVEDTIREVFERYGFQEIRTPIFEYTELFARKIGEDIVEKeMYTFEDR-GGRSLTLRPEGTAPVARAVA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  91 -HLLNRQGVTRLCYAGHVM-HTRP---RglhaTREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGV 165
Cdd:COG0124   91 eHGNELPFPFKLYYIGPVFrYERPqkgR----YRQFHQFGVEVIGSDSPLADAEVIALAADLLKALGLKDFTLEINSRGL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 166 laallardtqAAARGEALYDALSGKD-VPLLNELTDD-LGADTRAALRALPHLYGDA--SVLDEARQRLPALPEiaRALD 241
Cdd:COG0124  167 ----------PEERAEALLRYLDKLDkIGHEDVLDEDsQRRLETNPLRAILDSKGPDcqEVLADAPKLLDYLGE--EGLA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 242 DLAQLAAQAKGAEVAIDLaDL---RGYAYHSGAMFTAYID--GVPNAIARGGRYDH-VGQAYGRARPATGFS------LD 309
Cdd:COG0124  235 HFEEVLELLDALGIPYVI-DPrlvRGLDYYTGTVFEIVTDglGAQGSVCGGGRYDGlVEQLGGPPTPAVGFAiglerlLL 313

                        330
                 ....*....|....*...
gi 493449412 310 LRELARISPVEARGTAIL 327
Cdd:COG0124  314 LLEELGLLPAAEPPPDVY 331
PLN02530 PLN02530
histidine-tRNA ligase
 34-306 2.49e-08

histidine-tRNA ligase


Pssm-ID: 178145 [Multi-domain]  Cd Length: 487  Bit Score: 55.52  E-value: 2.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  34 SYGYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQlSGRTLGLRADITPQVARIdahLLNRQGVTRL---------CYA 104
Cdd:PLN02530 100 LFGFEEVDAPVLESEELYIRKAGEEITDQLYNFEDK-GGRRVALRPELTPSLARL---VLQKGKSLSLplkwfaigqCWR 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 105 GHVMhTRPRglhaTREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGL--SRIRLDLCHAGVLAALLAR---DTQAAAR 179
Cdd:PLN02530 176 YERM-TRGR----RREHYQWNMDIIGVPGVEAEAELLAAIVTFFKRVGItsSDVGIKVSSRKVLQAVLKSygiPEESFAP 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 180 GEALYDALSGKDVPLLNELTDDLGADTRAALRALphlygDASVLDEARQRLPALPEIARALDDLAQLAAQAKGAEVA--- 256
Cdd:PLN02530 251 VCVIVDKLEKLPREEIEKELDTLGVSEEAIEGIL-----DVLSLKSLDDLEALLGADSEAVADLKQLFSLAEAYGYQdwl 325

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 493449412 257 -IDLADLRGYAYHSGAMFTAY-IDGVPNAIARGGRYDHVGQAYG-RARPATGF 306
Cdd:PLN02530 326 vFDASVVRGLAYYTGIVFEGFdRAGKLRAICGGGRYDRLLSTFGgEDTPACGF 378
hisZ PRK12295
ATP phosphoribosyltransferase regulatory subunit; Provisional
 36-315 2.96e-08

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 183413 [Multi-domain]  Cd Length: 373  Bit Score: 54.94  E-value: 2.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  36 GYEMVMPPLLEYLESLLTSGGADLRLRTFKLVDQLsGRTLGLRADITPQVARidAHLLNRQG-VTRLCYAGHVMHTRPRG 114
Cdd:PRK12295  22 GAVRVDPPILQPAEPFLDLSGEDIRRRIFVTSDEN-GEELCLRPDFTIPVCR--RHIATAGGePARYAYLGEVFRQRRDR 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 115 LhatREQIQIGAEIYGHAGLE-ADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAAL-------------LARDTQAAARG 180
Cdd:PRK12295  99 A---SEFLQAGIESFGRADPAaADAEVLALALEALAALGPGDLEVRLGDVGLFAALvdalglppgwkrrLLRHFGRPRSL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 181 EALYDALSGKDVPLLNELTDDLGADT-RAALRALPH----------------------------LYGDASVLDEARQRLP 231
Cdd:PRK12295 176 DALLARLAGPRVDPLDEHAGVLAALAdEAAARALVEdlmsiagispvggrspaeiarrllekaaLAAAARLPAEALAVLE 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 232 ALPEIARALDD-LAQLAAQAKGAEVAIDLA----------------DL----------RGYAYHSGAMFTAYIDGVPNA- 283
Cdd:PRK12295 256 RFLAISGPPDAaLAALRALAADAGLDLDAAldrfearlaalaargiDLerlrfsasfgRPLDYYTGFVFEIRAAGNGDPp 335

                        330       340       350
                 ....*....|....*....|....*....|....
gi 493449412 284 IARGGRYDHVGQAYGRAR--PATGFSLDLRELAR 315
Cdd:PRK12295 336 LAGGGRYDGLLTRLGAGEpiPAVGFSIWLDRLAA 369
PLN02972 PLN02972
Histidyl-tRNA synthetase
 43-308 2.50e-07

Histidyl-tRNA synthetase


Pssm-ID: 215525 [Multi-domain]  Cd Length: 763  Bit Score: 52.58  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  43 PLLEYLESLLTSGGADLRLrTFKLVDQlSGRTLGLRADITPQVARIDAhlLNRQGVTRLCYAGHVMHTRPRGLHATREQI 122
Cdd:PLN02972 366 PVFELRETLMGKYGEDSKL-IYDLADQ-GGELCSLRYDLTVPFARYVA--MNGITSFKRYQIAKVYRRDNPSKGRYREFY 441

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 123 QIGAEIYG-HAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGVLAALLA--------------------RDTQAAARGE 181
Cdd:PLN02972 442 QCDFDIAGvYEPMGPDFEIIKVLTELLDELDIGTYEVKLNHRKLLDGMLEicgvppekfrticssidkldKQSFEQVKKE 521

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 182 ALYDalsgKDVPllNELTDDLG--ADTRAA-LRALPHLYGDAS-VLDEARQRlpalpeiaRALDDLAQL--AAQAKGA-- 253
Cdd:PLN02972 522 MVEE----KGLS--NETADKIGnfVKERGPpLELLSKLRQEGSeFLGNASSR--------AALDELEIMfkALEKSKAig 587

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 493449412 254 EVAIDLADLRGYAYHSGAMFTAYIDGVP-NAIARGGRYDH-VGQAYGRARPATGFSL 308
Cdd:PLN02972 588 KIVFDLSLARGLDYYTGVIYEAVFKGAQvGSIAAGGRYDNlVGMFSGKQVPAVGVSL 644
PRK12420 PRK12420
histidyl-tRNA synthetase; Provisional
 34-310 1.95e-06

histidyl-tRNA synthetase; Provisional


Pssm-ID: 237097 [Multi-domain]  Cd Length: 423  Bit Score: 49.34  E-value: 1.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  34 SYGYEMVMPPLLEYLEsLLTS---GGADLRLRTFKLVDQlSGRTLGLRADITPQVARIDAhlLN---RQGVTRlcYA-GH 106
Cdd:PRK12420  34 RYGCKPLETPTLNMYE-LMSSkygGGDEILKEIYTLTDQ-GKRDLALRYDLTIPFAKVVA--MNpniRLPFKR--YEiGK 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 107 VMHTRPRGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSrIRLDLCHAGVLAALLARDTQAAARGEALYDA 186
Cdd:PRK12420 108 VFRDGPIKQGRFREFIQCDVDIVGVESVMAEAELMSMAFELFRRLNLE-VTIQYNNRKLLNGILQAIGIPTELTSDVILS 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 187 LS-----GKDvPLLNELTdDLGADTRAALRALPHLY-GDASVLDEARQRL--PALPEIARALDDLAQ-LAAQAKGAEVAI 257
Cdd:PRK12420 187 LDkiekiGID-GVRKDLL-ERGISEEMADTICNTVLsCLQLSIADFKEAFnnPLVAEGVNELQQLQQyLIALGINENCIF 264

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 258 D--LAdlRGYAYHSGAMFTAYI-DG-VPNAIARGGRYDH-VGQAYG--RARPATGFSLDL 310
Cdd:PRK12420 265 NpfLA--RGLTMYTGTVYEIFLkDGsITSSIGSGGRYDNiIGAFRGddMNYPTVGISFGL 322
syh CHL00201
histidine-tRNA synthetase; Provisional
 12-316 3.05e-04

histidine-tRNA synthetase; Provisional


Pssm-ID: 164576 [Multi-domain]  Cd Length: 430  Bit Score: 42.58  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  12 DVLPSEARKIEELRRRLLDRFRSYGYEMVMPPLLEYLESLLTSGGADLRL---RTFKLVDQlSGRTLGLRADITPQVAR- 87
Cdd:CHL00201  12 DILPDEINYWQFIHDKALTLLSLANYSEIRTPIFENSSLYDRGIGETTDIvnkEMYRFTDR-SNRDITLRPEGTAGIVRa 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  88 -IDAHLLNRQGVTRLCYAGHVM-HTRPRGlHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLAGLSRIRLDLCHAGV 165
Cdd:CHL00201  91 fIENKMDYHSNLQRLWYSGPMFrYERPQS-GRQRQFHQLGIEFIGSIDARADTEVIHLAMQIFNELQVKNLILDINSIGK 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 166 LaallaRDTQAaargealYDAlsgKDVPLLNELTDDLGADTRAALRALPhlygdASVLDEARQRLPALPEIARALDDLAQ 245
Cdd:CHL00201 170 L-----EDRQS-------YQL---KLVEYLSQYQDDLDTDSQNRLYSNP-----IRILDSKNLKTQEILDGAPKISDFLS 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 246 LAAQAKGAEVAIDLADL-----------RGYAYHSGAMFTAYIDGV--PNAIARGGRYDH-VGQAYGRARPATGFSLDLR 311
Cdd:CHL00201 230 LESTEHFYDVCTYLNLLnipykinyklvRGLDYYNDTAFEIKTLSSngQDTICGGGRYDSlIHQLGGPKTPAVGCAIGLE 309


                 ....*
gi 493449412 312 ELARI 316
Cdd:CHL00201 310 RLLLI 314
hisZ PRK12293
ATP phosphoribosyltransferase regulatory subunit; Provisional
 34-308 4.14e-03

ATP phosphoribosyltransferase regulatory subunit; Provisional


Pssm-ID: 183411  Cd Length: 281  Bit Score: 38.82  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412  34 SYGYEMVMPPLLEYLESLLTSGGADLrlrtFKLVDQlSGRTLGLRADITPQVARIDAHLLNR-QGVTRLCYaghvmhTRP 112
Cdd:PRK12293  35 ENGFEEIVTPFFSYHQHQSIADEKEL----IRFSDE-KNHQISLRADSTLDVVRIVTKRLGRsTEHKKWFY------IQP 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 113 RGLHATREQIQIGAEIYGHAGLEADLEIQQLMLDALHLA---GLSRIRLDLchagVLAALLARDTQAAARGEaLYDALSg 189
Cdd:PRK12293 104 VFRYPSNEIYQIGAELIGEEDLSEILNIAAEIFEELELEpilQISNIKIPK----LVAEILGLDIEVFKKGQ-IEKLLA- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493449412 190 KDVPLLNELTddlgadtraalralphLYGDASVLDEARQRLPAlpEIARALDDLAQLAAQAKGAEVAIDL---ADLRGYA 266
Cdd:PRK12293 178 QNVPWLNKLV----------------RIKTLEDLDEVIELVPD--EIKEELEKLKELAESIKYENLVIAPlyyAKMRYYD 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 493449412 267 yhsgAMFTAYIDGvpNAI-ARGGRYDHVGQaygrarPATGFSL 308
Cdd:PRK12293 240 ----DLFFRFFDG--NSTlASGGNYEIDGI------SSSGFAL 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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