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Conserved domains on  [gi|493530448|ref|WP_006484459|]
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MULTISPECIES: Bax inhibitor-1/YccA family protein [Burkholderia]

Protein Classification

Bax inhibitor-1/YccA family protein( domain architecture ID 10179640)

Bax inhibitor-1/YccA family protein similar to Escherichia coli YccA, which negatively regulates the FtsH protease and is degraded by in an FtsH-dependent manner

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
19-229 6.97e-70

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


:

Pssm-ID: 198415  Cd Length: 205  Bit Score: 212.83  E-value: 6.97e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  19 VRNRVLRNTYWLLALSMVPTVLGAWVGVATGfslfaatSPMMSLLAFFAIAFGFMFAIERTKNSAAGVFVLLGFTFFMGL 98
Cdd:cd10433    2 STNKVLRNTYMLLSMTLAFSALGAGVSMAGG-------SPIMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFTGFMGY 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  99 MLSRLLSFILGFSNGPSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIFLQLPALMLTVSVL 178
Cdd:cd10433   75 TLGPILNMYLALPNGGQIIMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAA 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 493530448 179 AIAIFSAYMLFDVQRVVNGGETNYISATLAIYLDLYNVFTNLLALLGIFGG 229
Cdd:cd10433  155 FVLFSSGFILYDTSRIIHGGETNYIMATVSLYVSIYNLFVSLLNLLGAFSG 205
 
Name Accession Description Interval E-value
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
19-229 6.97e-70

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 212.83  E-value: 6.97e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  19 VRNRVLRNTYWLLALSMVPTVLGAWVGVATGfslfaatSPMMSLLAFFAIAFGFMFAIERTKNSAAGVFVLLGFTFFMGL 98
Cdd:cd10433    2 STNKVLRNTYMLLSMTLAFSALGAGVSMAGG-------SPIMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFTGFMGY 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  99 MLSRLLSFILGFSNGPSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIFLQLPALMLTVSVL 178
Cdd:cd10433   75 TLGPILNMYLALPNGGQIIMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAA 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 493530448 179 AIAIFSAYMLFDVQRVVNGGETNYISATLAIYLDLYNVFTNLLALLGIFGG 229
Cdd:cd10433  155 FVLFSSGFILYDTSRIIHGGETNYIMATVSLYVSIYNLFVSLLNLLGAFSG 205
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
1-225 3.70e-58

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 183.84  E-value: 3.70e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448   1 MNDYPYNFGRGGSVStAEVRNRVLRNTYWLLALSMVPTVLGAWVGVAT-GFSLFAATSPMMSLLAFFAiAFGFMFAIERT 79
Cdd:COG0670    1 MNNFDRNAGAAAAAS-DAGLRKVLRNTYGLLALGLLLTALVAYLGMALpGLAALLFGSPGLFWVLLIA-PLGLVFLLSKL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  80 ---KNSAAGVFVLLGFTFFMGLMLSRLLSFILGFSnGPSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVI 156
Cdd:COG0670   79 anrANSAAALALLFAYTALMGLTLSPILLVYTGLS-GPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGL 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493530448 157 LLASVANIFLQLPALMLTVSVLAIAIFSAYMLFDVQRVVNGGETN--YISATLAIYLDLYNVFTNLLALLG 225
Cdd:COG0670  158 IIASLVNIFLQSPALSLAISVAGVLLFSGLTLYDTQRIKHGYETNkqYIMAALSLYLDFINLFLSLLRLLG 228
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
21-224 6.71e-34

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 120.74  E-value: 6.71e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448   21 NRVLRNTYWLLALSMVPTVLGAWVGVATGFSLFAATSPMMSLLAFFA----IAFGFMFAIERTKNSAAGVFVLLGFTFFM 96
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAplglLFGALLLARKRKYSSNVALLLLLAFTLLM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448   97 GLMLSRLLSFILgfsngPSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIFLQLPALMLTVS 176
Cdd:pfam01027  81 GLTLGPLLLVYT-----GAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAIS 155
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 493530448  177 VLAIAIFSAYMLFDVQRVVNGGETN----YISATLAIYLDLYNVFTNLLALL 224
Cdd:pfam01027 156 YLGVLLFSGFILYDTQRIIKRYGEYgdydAILAALSLYLDFINLFLSLLRIL 207
PRK10447 PRK10447
FtsH protease modulator YccA;
21-230 3.36e-31

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 114.17  E-value: 3.36e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  21 NRVLRNTYWLLALSMVPTVLgawvgVATGFSLFAATSPmmSLLAFFAIAFGFMFAIERTKNSAAGVFVLLGFTFFMGLML 100
Cdd:PRK10447  18 HKVLRNTYFLLSLTLAFSAI-----TATASTVLMLPSP--GLILTLVGMYGLMFLTYKTANKPTGILSAFAFTGFLGYIL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448 101 SRLLSFILGFSNGpSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIFLQLPALMLTVSVLAI 180
Cdd:PRK10447  91 GPILNTYLSAGMG-DVIALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFI 169
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 493530448 181 AIFSAYMLFDVQRVVNGGETNYISATLAIYLDLYNVFTNLLALLGIFGGN 230
Cdd:PRK10447 170 LISSGAILFETSNIIHGGETNYIRATVSLYVSLYNIFVSLLSILGFASRD 219
 
Name Accession Description Interval E-value
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
19-229 6.97e-70

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 212.83  E-value: 6.97e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  19 VRNRVLRNTYWLLALSMVPTVLGAWVGVATGfslfaatSPMMSLLAFFAIAFGFMFAIERTKNSAAGVFVLLGFTFFMGL 98
Cdd:cd10433    2 STNKVLRNTYMLLSMTLAFSALGAGVSMAGG-------SPIMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFTGFMGY 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  99 MLSRLLSFILGFSNGPSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIFLQLPALMLTVSVL 178
Cdd:cd10433   75 TLGPILNMYLALPNGGQIIMTALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAA 154
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 493530448 179 AIAIFSAYMLFDVQRVVNGGETNYISATLAIYLDLYNVFTNLLALLGIFGG 229
Cdd:cd10433  155 FVLFSSGFILYDTSRIIHGGETNYIMATVSLYVSIYNLFVSLLNLLGAFSG 205
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
1-225 3.70e-58

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 183.84  E-value: 3.70e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448   1 MNDYPYNFGRGGSVStAEVRNRVLRNTYWLLALSMVPTVLGAWVGVAT-GFSLFAATSPMMSLLAFFAiAFGFMFAIERT 79
Cdd:COG0670    1 MNNFDRNAGAAAAAS-DAGLRKVLRNTYGLLALGLLLTALVAYLGMALpGLAALLFGSPGLFWVLLIA-PLGLVFLLSKL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  80 ---KNSAAGVFVLLGFTFFMGLMLSRLLSFILGFSnGPSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVI 156
Cdd:COG0670   79 anrANSAAALALLFAYTALMGLTLSPILLVYTGLS-GPASIAQAFGGTAATFGGLSLYGYTTKRDLSFLGSFLFMGLIGL 157
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493530448 157 LLASVANIFLQLPALMLTVSVLAIAIFSAYMLFDVQRVVNGGETN--YISATLAIYLDLYNVFTNLLALLG 225
Cdd:COG0670  158 IIASLVNIFLQSPALSLAISVAGVLLFSGLTLYDTQRIKHGYETNkqYIMAALSLYLDFINLFLSLLRLLG 228
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
20-225 1.63e-36

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 127.68  E-value: 1.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  20 RNRVLRNTYWLLALSMVPTVLGAWVGVATGFSLFAATSPMMSLLAF--FAIAFGFMFAIeRTKNSAAGVFVLLGFTFFMG 97
Cdd:cd10432    2 LRSFMKKVYGLMAAGLLLTAVGAYVGASTPALLLIAGSPLMWVLLIaeLALVFGLSFRI-NKMSVATALPLFFAFAALTG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  98 LMLSRLLSFILGFSngpslIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIFLQLPALMLTVSV 177
Cdd:cd10432   81 LTLSPILLVYTGAS-----IAQAFFTTAATFGGLSLYGYTTKKDLSFLGSFLFMGLIGLIIASLVNIFLQSSALQFAISA 155
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 493530448 178 LAIAIFSAYMLFDVQRVVNG--------GETNYISATLAIYLDLYNVFTNLLALLG 225
Cdd:cd10432  156 IGVLIFSGLIAYDTQRIKRMyeagggesGYKDAIMGALSLYLDFINLFLFLLRLFG 211
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
21-224 6.71e-34

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 120.74  E-value: 6.71e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448   21 NRVLRNTYWLLALSMVPTVLGAWVGVATGFSLFAATSPMMSLLAFFA----IAFGFMFAIERTKNSAAGVFVLLGFTFFM 96
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLTAAVAYLVLSSPALLFPSLHPPLFWVLIIAplglLFGALLLARKRKYSSNVALLLLLAFTLLM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448   97 GLMLSRLLSFILgfsngPSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIFLQLPALMLTVS 176
Cdd:pfam01027  81 GLTLGPLLLVYT-----GAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAIS 155
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 493530448  177 VLAIAIFSAYMLFDVQRVVNGGETN----YISATLAIYLDLYNVFTNLLALL 224
Cdd:pfam01027 156 YLGVLLFSGFILYDTQRIIKRYGEYgdydAILAALSLYLDFINLFLSLLRIL 207
PRK10447 PRK10447
FtsH protease modulator YccA;
21-230 3.36e-31

FtsH protease modulator YccA;


Pssm-ID: 182469  Cd Length: 219  Bit Score: 114.17  E-value: 3.36e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  21 NRVLRNTYWLLALSMVPTVLgawvgVATGFSLFAATSPmmSLLAFFAIAFGFMFAIERTKNSAAGVFVLLGFTFFMGLML 100
Cdd:PRK10447  18 HKVLRNTYFLLSLTLAFSAI-----TATASTVLMLPSP--GLILTLVGMYGLMFLTYKTANKPTGILSAFAFTGFLGYIL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448 101 SRLLSFILGFSNGpSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIFLQLPALMLTVSVLAI 180
Cdd:PRK10447  91 GPILNTYLSAGMG-DVIALALGGTALVFFCCSAYVLTTRKDMSFLGGMLMAGIVVVLIGMVANIFLQLPALHLAISAVFI 169
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 493530448 181 AIFSAYMLFDVQRVVNGGETNYISATLAIYLDLYNVFTNLLALLGIFGGN 230
Cdd:PRK10447 170 LISSGAILFETSNIIHGGETNYIRATVSLYVSLYNIFVSLLSILGFASRD 219
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
19-225 8.03e-20

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 83.62  E-value: 8.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  19 VRNRVLRNTYWLLALSMVPTVLGAWVGVATGFSLFAATSPMMSLLAFFAIAFgfmFAIERTKNSAAGVFVLLGFTFFMGL 98
Cdd:cd06181    1 STKDFLRKVYMILALQLLLTAATATAFTVCDPGWYWSPALMGLLTSMLALMA---TAAMIRAKMPVNLILLFGFTGLMGY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  99 MLSRLLSFIlgfsnGPSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIFLQLPALMLTVSVL 178
Cdd:cd06181   78 VVGPLLFFY-----GPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAAV 152
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 493530448 179 AIAIFSAYMLFDVQRVVNG---GETNYISATLAIYLDLYNVFTNLLALLG 225
Cdd:cd06181  153 GLVLFCGFLLYDTQLIIHKaevGPEDYINACISLYLDIINIFIRLLTILA 202
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
22-224 1.12e-15

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 73.03  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  22 RVLRNTYWLLALSMVPTVLGAWVgvatgfSLFAATSPMMSLLAFFAIAFGFMFAIERTKNSAAGVFVLLGFTFFMGLMLS 101
Cdd:cd10430   10 QHLKKVYLTLAVALLAAAVGAYV------HMVINIGGLLTGLLSLGLSLWLAFTPSTGKNEPKRLGLLLGFAFLTGASLG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448 102 RLLSFILGFSngPSLIMLAFGGTGIIFATMATIATVSK-RDFSGLGKWLFMGVIVILLASVANIFLQLPALMLTVSVLAI 180
Cdd:cd10430   84 PLLDLVIAIN--PSIIVTAFLGTAVIFACFSLAALLAKrREYLYLGGLLSSALSILLLVSLANIFGGSKFLFQAELYLGL 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 493530448 181 AIFSAYMLFDVQRVV---NGGETNYISATLAIYLDLYNVFTNLLALL 224
Cdd:cd10430  162 LVFCGFVLFDTQMIIekaENGDRDYIWHALDLFVDFVALFRRLLIIL 208
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
2-225 5.41e-15

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 71.48  E-value: 5.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448   2 NDYPYNFGRGGSVSTAEV--RNRVLRNTYWLLALSMVPTVL-GAWVGVATGFSLFAATSPMMSLLAFFaIAFGFMFA-IE 77
Cdd:cd10429    7 ADIPDDFKYGTNVASAEPeiRMAFLRKVYSILSVQLLATTAvSALFYLSPSIKTFVQSHPWLFLISLI-GSLILLIAlYW 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  78 RTKNSAAGVFVLLGFTFFMGLMLSRLLSFILGfsngpSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGV-IVI 156
Cdd:cd10429   86 KRHSHPVNLILLSLFTLCEAYTVGLVVSFYDG-----KIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLwALI 160
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448 157 LLASVANIFLQLPALMLTVSVLAIAIFSAYMLFDVQRVVNGGETN-YISATLAIYLDLYNVFTNLLALLG 225
Cdd:cd10429  161 LLALIFQFFPYSPTFELVYAGLGALLFSGYIVYDTQLIMKRLSPDeYILAAISLYLDIINLFLSILRILA 230
GHITM cd10431
Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in ...
19-231 3.25e-11

Growth-hormone inducible transmembrane protein; GHITM appears to be ubiquitiously expressed in mammalian cells and expression has also been observed in various cancer cell lines. A cytoprotective function has been suggested. It is closely related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect.


Pssm-ID: 198413  Cd Length: 264  Bit Score: 61.24  E-value: 3.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  19 VRNRvLRNTYWLLALSMVPTVLGAWVGVATGFSL-FAATSPMMSLLAFFAIAFGFMF---AIERTKNSAAGVFVLLGFTF 94
Cdd:cd10431   40 VRDR-IHSTYMYFGGSLGLTALAAVALSRSPALMrLMAAGPWLAIGATLAAMIGSGMlvrSYTYPENPGAKHLAWLGHSG 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  95 FMGLMLSRLLsfilgFSNGPSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIFLQLPA--LM 172
Cdd:cd10431  119 VQGAVLAPLC-----FLGGPLLIRAALYTAGIVGGLSTVAACAPSEKFLYMGGPLAIGLGVVFASSLGSMFLPPTTalGA 193
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 493530448 173 LTVSVL---AIAIFSAYMLFDVQRVVNGGET---------NYISATLAIYLDLYNVFTNLLALLGIFGGNR 231
Cdd:cd10431  194 GLYSVSlygGLVLFGGFLLYDTQKIIKRAEThplygvrkyDPINASMSIYMDTINIFIRLVTILAGGGNRR 264
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
87-225 7.65e-11

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 59.48  E-value: 7.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 493530448  87 FVLLG-FTFFMGLMLSRLLSFilgfsNGPSLIMLAFGGTGIIFATMATIATVSKRDFSGLGKWLFMGVIVILLASVANIF 165
Cdd:cd10428   78 LILLGiFTLAMSYMLGTIASF-----YDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIF 152
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 493530448 166 LQLPALMLTVSVLAIAIFSAYMLFDVQRVVNGG-----ETNYISATLAIYLDLYNVFTNLLALLG 225
Cdd:cd10428  153 FYVKWLHIVYASLGALLFSLYLAVDTQLLMGGRkyelsPEEYIFAALNIYVDIVNIFLYILQLIG 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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